Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF-06424439 methanesulfonate 是一种口服有效咪唑并吡啶二酰基甘油酰基转移酶 2 (DGAT2)选择性抑制剂,IC50是14 nM。PF-06424439 methanesulfonate 具有缓慢可逆,时间依赖性的特点,其相对于酰基-CoA 底物以非竞争性模式抑制 DGAT2。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 397 | 现货 | ||
5 mg | ¥ 788 | 现货 | ||
10 mg | ¥ 997 | 现货 | ||
25 mg | ¥ 1,980 | 现货 | ||
50 mg | ¥ 3,320 | 现货 | ||
100 mg | ¥ 4,880 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 928 | 现货 |
产品描述 | PF-06424439 methanesulfonate, an orally administered, potent, and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM, demonstrates slow reversibility and time-dependent inhibition. It operates in a noncompetitive manner relative to the acyl-CoA substrate, marking its efficacy in targeting DGAT2. |
靶点活性 | DGAT-2:14 nM |
体内活性 | PF-06424439 methanesulfonate shows moderate clearance in rats following intravenous administration and moderate steady-state volume of distribution (Vdss) results in a short half-life[1]. |
动物实验 | PF-06424439 methanesulfonate (i.v.; 1 mg/kg) shows moderate clearance in rats following intravenous administration and moderate steady-state volume of distribution (Vdss) results in a short half-life[1].PF-06424439 methanesulfonate (p.o.; 60 mg/kg/day; for 3 days) reduces plasma TG and cholesterol levels and decreases nonsignificant in circulating lipids in mice (Ldlr-/-)[1]. |
分子量 | 536.05 |
分子式 | C23H30ClN7O4S |
CAS No. | 1469284-79-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 249 mg/mL (464.50 mM), Sonification is recommended.
H2O: 99 mg/mL (184.68 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 1.8655 mL | 9.3275 mL | 18.655 mL | 46.6374 mL |
5 mM | 0.3731 mL | 1.8655 mL | 3.731 mL | 9.3275 mL | |
10 mM | 0.1865 mL | 0.9327 mL | 1.8655 mL | 4.6637 mL | |
20 mM | 0.0933 mL | 0.4664 mL | 0.9327 mL | 2.3319 mL | |
50 mM | 0.0373 mL | 0.1865 mL | 0.3731 mL | 0.9327 mL | |
100 mM | 0.0187 mL | 0.0933 mL | 0.1865 mL | 0.4664 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PF-06424439 methanesulfonate 1469284-79-4 Metabolism Acyltransferase Transferase acyl-CoA:cholesterol acyltransferase Inhibitor mono- acylglycerol acyltransferase PF-06424439 PF 06424439 methanesulfonate inhibit Diacylglycerol acyltransferase PF06424439 Diglyceride acyltransferase PF06424439 methanesulfonate PF 06424439 inhibitor