Powder: -20°C for 3 years | In solvent: -80°C for 1 year
7-Methoxyflavone 是一种分离自 Zornia brasiliensis 的化合物。它能够抑制福尔马林疼痛反应神经源期的舔爪时间 (65.6%),有外周镇痛活性,但不影响炎症期的伤害性反映。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
100 mg | ¥ 510 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 190 | 现货 |
产品描述 | 7-Methoxyflavone isolated from Zornia brasiliensis with antinociceptive effects. |
体内活性 | The antinociceptive effect of 7-methoxyflavone (7MF) in mice using the following tests: acetic acid-induced writhing, glutamate- and formalin-induced nociception and hotplate. 7MF (30, 50, 100 and 300 μmol/kg, i.p.) reduced the number of writhes, with ID?? = 82.5 ± 11.7 μmol/kg and E max = 58.4%. 7MF treatment (100 μmol/kg, i.p.) inhibited paw-licking time in the neurogenic phase of the formalin pain response (65.6%) and did not decrease the nociceptive response in the inflammatory phase. In addition, in glutamate-induced nociception, 7MF inhibited 26% of the nociceptive answer. On the other hand, 7MF did not increase the latency time of the animals in the hotplate test. These results suggest that 7MF has peripheral antinociceptive activity |
分子量 | 252.26 |
分子式 | C16H12O3 |
CAS No. | 22395-22-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (99.1 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.9642 mL | 19.8208 mL | 39.6416 mL | 99.1041 mL |
5 mM | 0.7928 mL | 3.9642 mL | 7.9283 mL | 19.8208 mL | |
10 mM | 0.3964 mL | 1.9821 mL | 3.9642 mL | 9.9104 mL | |
20 mM | 0.1982 mL | 0.991 mL | 1.9821 mL | 4.9552 mL | |
50 mM | 0.0793 mL | 0.3964 mL | 0.7928 mL | 1.9821 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
7-Methoxyflavone 22395-22-8 Others 7Methoxyflavone Inhibitor peripheral antinociceptive 7 Methoxyflavone inflammatory inhibit paw-licking time inhibitor