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114

抑制剂 & 化合物

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Cat. No. Product Name
L3600 细胞因子抑制剂库

604 compounds
604 个与细胞因子紧密相关的化合物集合,是高通量、高内涵筛选的良好载体;
L2800 5-羟色胺分子库

268 compounds
268 种生物活性小分子化合物,用于高通量、高内涵筛选;
L6750 活血化瘀中药单体库

580 compounds
580种来源于常见活血化瘀中药的单体化合物,是药物开发、药理研究等领域的有效工具。
L4700 免疫/炎症分子化合物库

4720 compounds
4720 种具有抗炎症活性的化合物的特有集合,可用于高通量筛选和高内涵筛选;
L9600 多肽分子库

791 compounds
791 种多肽类分子,可用于多肽药物开发及信号转导通路和作用机制研究;
L7200 钙通道分子库

140 compounds
140 种钙通道相关化合物的独特集合,可用于高通量筛选和高内涵筛选;
L9840 抗阿尔茨海默症化合物库

986 compounds
986 种阿尔茨海默症相关的化合物集合,可用于高通量和高内涵筛选;
L9410 共价抑制剂库

1920 compounds
1920 种小分子的独特集合,包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子,如氯乙酰基,2-氯丙酰基,丙烯酰基,1-丙-2-炔基,1-丁-2-炔基,酮羰基,二硫键等,可以用于共价抑制剂药物研发;

化合物库

细胞因子抑制剂库
Cat.No: L3600
Compounds: 604
5-羟色胺分子库
Cat.No: L2800
Compounds: 268
活血化瘀中药单体库
Cat.No: L6750
Compounds: 580
免疫/炎症分子化合物库
Cat.No: L4700
Compounds: 4720
多肽分子库
Cat.No: L9600
Compounds: 791
钙通道分子库
Cat.No: L7200
Compounds: 140
抗阿尔茨海默症化合物库
Cat.No: L9840
Compounds: 986
共价抑制剂库
Cat.No: L9410
Compounds: 1920
Cat. No. Product Name Target Signaling Pathways
T8998 AA41612

Others Others
AA41612 是一种有效的黑素蛋白介导的光转导的拮抗剂。
TP1422 Interleukin (IL)-6 Receptor

Others Others
Interleukin (IL)-6 Receptor 是一种肽,来源于白细胞介素6受体。
T3571 SU5201

NSC 247030

Others; Interleukin Immunology/Inflammation; Others
SU5201 (NSC 247030) 对白细胞介素 2 (IL-2) 的产生具有抑制作用。
T12579 RAMB4

PTP1B-IN-9

Proteasome Proteases/Proteasome; Ubiquitination
RAMB4 (PTP1B-IN-9) 是一种泛素-蛋白酶体系统(UPS)应激源,是通过抑制 20S 蛋白酶体催化活性物质上游泛素介导的蛋白质降解而产生。它能够在不影响 20S 蛋白酶体催化活性的情况下触发泛素蛋白酶体系统 (UPS) 应激反应。
T76724 Nemolizumab

CIM331

Interleukin Immunology/Inflammation
Nemolizumab (CIM331) 是一种人源化的抗人白细胞介素-31 受体 a 单克隆抗体,对白细胞介素-31 (IL-31) 与其受体的结合和随后的信号转导有抑制作用。Nemolizumab 可用于研究特应性皮炎伴瘙痒。
T4140 IRAK4-IN-1

IRAK Immunology/Inflammation; NF-κB
IRAK4-IN-1 是白细胞介素-1 受体相关激酶 4 抑制剂(IC50:7 nM)。
T5110 IRAK inhibitor 6

IRAK Immunology/Inflammation; NF-κB
IRAK inhibitor 6 是白细胞介素-1受体相关激酶-4的抑制剂(IC50:160 nM)。
T76744 Enokizumab

MEDI-528

IL Receptor Immunology/Inflammation
Enokizumab (MEDI-528) 是一种针对白介素 IL-9 的单克隆抗体。Enokizumab 可用于研究哮喘疾病。
T8423 ML417

Dopamine Receptor; Arrestin GPCR/G Protein; Neuroscience
ML417 是选择性的,可透过血脑屏障的 D3 多巴胺受体激动剂,EC50=38 nM。它能够促进 D3R 介导的 β-arrestin 易位、G 蛋白介导的信号传导和 pERK 磷酸化,对其他 GPCR 介导的信号传导影响小。它对毒素诱导的多巴胺能神经元变性具有神经保护活性。
T76722 Sarilumab

REGN-88,SAR-153191

IL Receptor Immunology/Inflammation
Sarilumab(SAR-153191) 是一种有效的白细胞介素-6 IL-6 受体拮抗剂,是人源免疫球蛋白 G1 单克隆抗体。 Sarilumab 抑制由 IL-6 介导的信号传导,可减少炎症。Sarilumab 可用于预防和治疗类风湿关节炎。
T1955 SB225002

CXCR Autophagy; GPCR/G Protein; Immunology/Inflammation
SB225002 是一种有效的选择性 CXCR2 拮抗剂,抑制白介素 IL-8 与 CXCR2 的结合,IC50为 22 nM。
T6465 Dexamethasone Sodium Phosphate

Dexadreson,地塞米松磷酸钠,Dexagro,Dalalone

IL Receptor; COX Immunology/Inflammation; Neuroscience
Dexamethasone Sodium Phosphate (Dexadreson) 是一种白细胞介素受体调节剂,具有抗炎和免疫抑制作用。它属于类固醇合成药物的强效糖皮质激素类。
T1919 Tenovin-1

Tenovin 1

Mdm2; Dehydrogenase; Sirtuin; p53; Autophagy Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
Tenovin-1 抑制 SirT1 和 SirT2 的蛋白质去乙酰化活性,并防止 MDM2 介导的 p53 降解,这涉及泛素化。它具有癌症的研究潜力。
T5641 RP-54745

Interleukin Immunology/Inflammation
RP-54745 是一种能抑制噬细胞刺激和的白介素-1 的产生的化合物,对风湿病的治疗具有潜在的研究价值。
T7572 RN-1734

2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺

TRP/TRPV Channel Membrane transporter/Ion channel
RN-1734是TRPV4通道的选择性拮抗剂,拮抗 4αPDD 介导的 TRPV4 活化,作用于 hTRPV4, mTRPV4, 和 rTRPV4的IC50分别为 2.3 μM、5.9 μM、3.2 μM。RN-1734能显著降低白细胞介素 1β和肿瘤坏死因子 α 的产生,而不改变 olig2- 阳性细胞的数量。
T1866 AT-56

Others; PGE Synthase Immunology/Inflammation; Others
AT56 是口服有活性的脂钙蛋白型前列腺素 D 合酶 (L-PGDS) 选择性抑制剂,其IC50=95 μM,Ki=75 μM。它能够特异性地抑制L-PGDS 催化的 PGD2介导的嗜睡或疼痛反应。
T70489 Enerisant HCl

P450; Histamine Receptor GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
Enerisant HCl是一种新型强效选择性组胺H3受体拮抗剂,是P-gp的底物,由细胞色素P450(CYP)和转运蛋白介导。
T9631 IRAK-4 protein kinase inhibitor 2

IRAK Immunology/Inflammation; NF-κB
IRAK-4 protein kinase inhibitor 2 是有效的白介素 1 受体相关激酶 4 抑制剂,IC50为 4 μM。它在与炎症和免疫相关的疾病领域有研究价值。
T76777 Bermekimab

MABp1

IL Receptor Immunology/Inflammation
Bermekimab (MABp1) 是一种人源化抗白介素-1α (IL-1α) 的单克隆抗体。Bermekimab 具有潜在的抗炎活性,可预防皮肤炎症。
T76779 Brodalumab

LP 0160,KHK-4827,AMG-827

IL Receptor Immunology/Inflammation
Brodalumab (AMG 827) 是一种人源靶向白介素 17 受体 (IL-17R) IgG2 的单克隆抗体,常作为免疫抑制剂来治疗银屑病和牛皮藓。
T11635 IL-17A antagonist 1

IL Receptor Immunology/Inflammation
IL-17A antagonist 1 是一种 IL-17A 拮抗剂,可用于研究和白介素相关的炎症和免疫疾病。
T67924 ABzOH

ABzOH 是一种苯甲酸衍生物,结构类似于阿司匹林等非甾体抗炎药,具有抗炎、抗肿瘤和抗增殖作用。ABzOH 不仅可以抑制肿瘤坏死因子- α (TNF-a)、白细胞介素-1β (IL-1β)和白细胞介素-6 (IL-6)等促炎细胞因子的表达还对乳腺癌、肺癌和胰腺癌具有抑制作用。
T67920 HPPE

HPPE 是一种非亲电子作用的 Bach1 选择性抑制剂。 HPPE 靶向 Bach1 蛋白上的血红素结合位点,从而减轻 Bach1 介导的抑制作用。
T7368 IRAK inhibitor 2

IRAK-IN-2

IRAK Immunology/Inflammation; NF-κB
IRAK inhibitor 2 (IRAK-IN-2) 是一种有效的白细胞介素1受体相关激酶4(IRAK-4)抑制剂,具有潜在的抗癌和抗癌活性,可用于研究炎症相关性疾病。
T22062 CCG-100602

Rho; Ras Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
CCG-100602 是心肌蛋白相关转录因子 A/血清反应因子信号转导的特异性抑制剂。它抑制 PC-3 前列腺癌细胞中 RhoA/C 介导的、SRF 驱动的荧光素酶表达,IC50为 9.8 µM。
T9203 JH-X-119-01

IRAK Immunology/Inflammation; NF-κB
JH-X-119-01 是白介素 1 受体相关激酶 1 的选择性抑制剂。它能够改善 LPS 诱导的小鼠败血症。它可以抑制 IRAK1(IC50:9 nM),在浓度达到 10 μM 时,也不会对 IRAK4 产生抑制作用。
T5354 IRAK4-IN-7

CA-4948

IRAK Immunology/Inflammation; NF-κB
IRAK4-IN-7 (CA-4948) 是白介素 1 受体相关激酶 4 (IRAK4) 的选择性抑制剂,口服有活性。它可用于研究癌症以及炎症疾病。
T9911 Tocilizumab

Interleukin Immunology/Inflammation
Tocilizumab 是抗人白细胞介素-6 受体 (IL-6R) 的中和抗体,能够阻碍 IL-6 与 IL-6R 的结合,进而抑制经典和反式信号。它可用于研究类风湿性关节炎,对重症 COVID-19 冠状病毒病方面的研究具有显著效果。
T12146 N-Desmethyl-Apalutamide

N-Desmethyl Apalutamide,N-去甲基阿帕鲁胺杂质

P450; Androgen Receptor Endocrinology/Hormones; Metabolism
N-Desmethyl-Apalutamide 是一种 Apalutamide 的活性代谢产物,主要由 CYP2C8 和 CYP3A4 介导形成。它是一种低活性的雄激素受体拮抗剂,其作用力是 Apalutamide 活性的三分之一。它是中等至强的CYP3A4和CYP2B6诱导剂,并具有优异的血浆蛋白结合浓度。
T73698 Basiliximab

CHI 621

Interleukin Immunology/Inflammation
Basiliximab (CHI 621) 是一种嵌合鼠/人 IgG1 单克隆抗白细胞介素 2 受体 (interleukin-2 receptor) 重组抗体。Basiliximab 具有良好的免疫抑制活性,可用于研究肾移植。
T16280 Nedocromil

FPL 59002,尼多克罗

Leukotriene Receptor; Prostaglandin Receptor; Histamine Receptor GPCR/G Protein; Immunology/Inflammation; Neuroscience
Nedocromil (FPL 59002) 对多种介质的作用或形成有抑制作用,包括组胺,前列腺素 D2和白三烯 C4。
T76775 Fezakinumab

ILV 094

Interleukin Immunology/Inflammation
Fezakinumab 是一种有效的白细胞介素 22 (IL-22) 单克隆抗体。Fezakinumab 可用于研究银屑病、类风湿性关节炎和特应性皮炎等免疫系统疾病和炎症相关疾病。
T21527 HBX 41108

HBX-41108,7-氯-9-氧代-9H-茚并[1,2-B]吡嗪-2,3-二甲腈

DUB; p53 Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
HBX 41108 (HBX-41108) 是一种泛素特异性蛋白酶 7 的非竞争性抑制剂,IC50为 424 nM。它诱导 p53 依赖的凋亡,抑制 USP7 介导的 p53 去泛素化以稳定 p53 并抑制癌细胞生长。
T9897 7-Methoxy-1-naphthaleneacetic acid

Others Others
7-Methoxy-1-naphthaleneacetic acid 是植物生长素作用的抑制剂。 7-Methoxy-1-naphthaleneacetic acid 抑制与拟南芥和玉米中生长素不对称分布相关的极性生长素转运和热带反应。 7-Methoxy-1-naphthaleneacetic acid 抑制由酵母中表达的 AUX1、PIN 和 ABCB 蛋白介导的生长素转运。
T68455 AP23846

AP-23846

Src Angiogenesis; Tyrosine Kinase/Adaptors
AP23846 是一种新型高效的 Src 家族激酶抑制剂,可降低人实体瘤细胞系中血管内皮生长因子和白细胞介素-8 的表达,并消除下游血管生成过程。
T11673 IRAK4-IN-4

IRAK; cGAS Immunology/Inflammation; NF-κB
IRAK4-IN-4 (化合物 15) 是白介素-1 受体相关激酶抑制剂,IC50为 2.8 nM。它还抑制环 GMP-AM 合酶 ,IC50为 2.1 nM。
T36534 SDZ 224-015

SDZ 224015

IL Receptor; Caspase Apoptosis; Immunology/Inflammation; Proteases/Proteasome
SDZ 224-015 是白细胞介素-1β(IL-1β)转化酶和 Caspase-1 的口服活性抑制剂。SDZ 224-015 具有抗 COVID-19 和抗炎活性,可减少角叉菜胶诱导的大鼠爪子水肿。
T25465 GS143

GS-143,GS 143

IκB/IKK; E1/E2/E3 Enzyme; NF-κB NF-κB; Ubiquitination
GS-143 是选择性的IκBα泛素化抑制剂,抑制 SCFβTrCP1介导的IκBα泛素化作用,IC50=5.2 μM。GS143 抑制NF-κB 的活化和靶基因的转录,并且不抑制蛋白酶体的特性,并具有抗哮喘作用。
T10497 Benralizumab

BIW-8405,MEDI-563

Apoptosis; IL Receptor; Interleukin Apoptosis; Immunology/Inflammation
Benralizumab (MEDI-563) 是一种靶向白介素 5 受体 α (IL-5Rα) 单克隆抗体,通过增强抗体依赖性细胞介导的细胞毒性促使嗜酸性粒细胞快速进行反应。Benralizumab 可用于严重的嗜酸性哮喘,可用于预防慢性阻塞性肺病加重。
TQ0167 Zimlovisertib

PF-06650833,PF06650833

IRAK Immunology/Inflammation; NF-κB
Zimlovisertib (PF-06650833) 是口服有活性的、可生物利用的白介素-1 受体相关激酶 4 (IRAK4) 选择性抑制剂,其IC50=0.2 nM,在 PBMC 分析中,IC50=2.4 nM。它具有研究类淋巴瘤、风湿性关节炎、狼疮等疾病的潜力。
T35569 CTA 056

Apoptosis Apoptosis
CTA 056 是白细胞介素-2 诱导的 T 细胞激酶(ITK)抑制剂,抑制小鼠 MOLT-4 异种移植肿瘤的生长,诱导 Jurkat 细胞凋亡,可用于研究自身免疫性疾病和T细胞恶性肿瘤。
T14367 AZ1495

IRAK; CDK; Haspin Kinase Cell Cycle/Checkpoint; Immunology/Inflammation; NF-κB
AZ1495 是一种口服有活性的白介素-1受体相关激酶 4(IRAK4)抑制剂,能够作用于 IRAK4 (IC50:5 nM)和 IRAK1 (IC50:23 nM)。可用于研究突变型 MYD88L265P 弥漫性 B 细胞淋巴瘤 (DLBCL) 。
T16695 Pyrintegrin

Integrin Cytoskeletal Signaling
Pyrintegrin 是一种 β1 整合素激动剂,也是 2,4-二取代的嘧啶,可促进胚胎干细胞存活。它可用作足细胞保护剂,能增强细胞-细胞外基质 (ECM) 粘附介导的整联蛋白信号传导,具有强大的成脂作用。
T60739L Y13g dihydrochloride

Y13g 2HCl(T60739 Free base)

IL Receptor; AChE Immunology/Inflammation; Neuroscience
Y13g dihydrochloride 是白细胞介素 6 (IL-6) 和乙酰胆碱酯酶 (AChE)的有效抑制剂(这两个靶点阿尔茨海默症 (AD) 进展的有关)。Y13g dihydrochloride 逆转 STZ 诱导的记忆缺陷,并表现出与正常动物相似的组织病理学。
T13666 Dupilumab

REGN-668,SAR-231893

IL Receptor Immunology/Inflammation
Dupilumab (REGN-668) 是一种用于AD 的全身免疫调节剂。Dupilumab 是一种针对白细胞介素-4受体α亚基的完全人类单克隆抗体,可抑制IL-4和IL-13下游信号传导,具有改善特应性皮炎的作用。
T12343 Benzquinamide

BZQ,P2647,Benzoquinamide

Adrenergic Receptor GPCR/G Protein; Neuroscience
Benzquinamide (P2647) 是一种具有抗癌活性的止吐剂, 抑制p糖蛋白介导的药物外排,增强多重耐药细胞中抗癌药物的细胞毒性。Benzquinamide 对 α2A, α2B, 以及α2C 肾上腺素能受体(α2-AR)的 Ki值分别为 1,365, 691 和 545 nM。
T34973 Tyrphostin 8

4-Hydroxybenzylidenemalononitrile

EGFR; GTPase Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Tyrphostin 8(4-Hydroxybenzylidenemalononitrile) 是一种有效的 GTP 酶抑制剂,对 EGFR 激酶有抑制作用, IC50 值为 560 μM。Tyrphostin 8 可抑制蛋白丝氨酸/苏氨酸钙调磷酸酶 (IC50=21 μM),增强 Caco-2 细胞中转铁蛋白受体介导的转吞作用,并增加口服胰岛素 - 转铁蛋白的降血糖作用。
T77353 MyD88-IN-1

IL Receptor; NF-κB; TLR; MyD88 Immunology/Inflammation; NF-κB
MyD88-IN-1 是一种有效的 MyD88 抑制剂。MyD88-IN-1 具有抗炎活性,可抑制 Toll 样受体 (TLR) 和白细胞介素-1 (IL-1) 受体家族成员下游炎症信号通路 ,包括NF-κB 通路。MyD88-IN-1 可用于研究癌症和治疗炎症。
T38105 Ixekizumab

LY2439821

IL Receptor; Interleukin Immunology/Inflammation
Ixekizumab (LY2439821) 是一种人源化 IgG4 单克隆抗体,可选择性结合和中和白细胞介素 IL-17A ,Kd 值<3 pM。Ixekizumab 科阻断 IL-17A 与 IL-17RA 的结合,但不与其他 IL-17 家族成员结合。Ixekizumab 用于治疗中重度斑块型银屑病、银屑病关节炎和牛皮癣。
T41142 EM 163

IL Receptor; p38 MAPK; MyD88 Immunology/Inflammation; MAPK
EM 163是一种 TIR-TIR 相互作用抑制剂,它是MyD88蛋白的TIR(Toll/白细胞介素-1受体)结构域拟态。EM 163针对IL-1受体中的TIR 结构域,阻断与MyD88的相互作用。EM 163抑制葡萄球菌肠毒素B(SEB)引起的体内炎症细胞因子的产生。EM 163能保护小鼠免受SEB 冲击引起的死亡。在体外的大鼠海马神经元中,EM 163阻断p38的激活和IL-1β对化学诱导的长期电位(LTP)引发的蛋白质合成的抑制作用。

化合物

AA41612
Cat.No: T8998
Synonym:
Target: Others
Interleukin (IL)-6 Receptor
Cat.No: TP1422
Synonym:
Target: Others
SU5201
Cat.No: T3571
Synonym: NSC 247030
Target: Others, Interleukin
RAMB4
Cat.No: T12579
Synonym: PTP1B-IN-9
Target: Proteasome
Nemolizumab
Cat.No: T76724
Synonym: CIM331
Target: Interleukin
IRAK4-IN-1
Cat.No: T4140
Synonym:
Target: IRAK
IRAK inhibitor 6
Cat.No: T5110
Synonym:
Target: IRAK
Enokizumab
Cat.No: T76744
Synonym: MEDI-528
Target: IL Receptor
ML417
Cat.No: T8423
Synonym:
Target: Dopamine Receptor, Arrestin
Sarilumab
Cat.No: T76722
Synonym: REGN-88,SAR-153191
Target: IL Receptor
SB225002
Cat.No: T1955
Synonym:
Target: CXCR
Dexamethasone Sodium Phosphate
Cat.No: T6465
Synonym: Dexadreson,地塞米松磷酸钠,Dexagro,Dalalone
Target: IL Receptor, COX
Tenovin-1
Cat.No: T1919
Synonym: Tenovin 1
Target: Mdm2, Dehydrogenase, Sirtuin, p53, Autophagy
RP-54745
Cat.No: T5641
Synonym:
Target: Interleukin
RN-1734
Cat.No: T7572
Synonym: 2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺
Target: TRP/TRPV Channel
AT-56
Cat.No: T1866
Synonym:
Target: Others, PGE Synthase
Enerisant HCl
Cat.No: T70489
Synonym:
Target: P450, Histamine Receptor
IRAK-4 protein kinase inhibitor 2
Cat.No: T9631
Synonym:
Target: IRAK
Bermekimab
Cat.No: T76777
Synonym: MABp1
Target: IL Receptor
Brodalumab
Cat.No: T76779
Synonym: LP 0160,KHK-4827,AMG-827
Target: IL Receptor
IL-17A antagonist 1
Cat.No: T11635
Synonym:
Target: IL Receptor
ABzOH
Cat.No: T67924
Synonym:
Target:
HPPE
Cat.No: T67920
Synonym:
Target:
IRAK inhibitor 2
Cat.No: T7368
Synonym: IRAK-IN-2
Target: IRAK
CCG-100602
Cat.No: T22062
Synonym:
Target: Rho, Ras
JH-X-119-01
Cat.No: T9203
Synonym:
Target: IRAK
IRAK4-IN-7
Cat.No: T5354
Synonym: CA-4948
Target: IRAK
Tocilizumab
Cat.No: T9911
Synonym:
Target: Interleukin
N-Desmethyl-Apalutamide
Cat.No: T12146
Synonym: N-Desmethyl Apalutamide,N-去甲基阿帕鲁胺杂质
Target: P450, Androgen Receptor
Basiliximab
Cat.No: T73698
Synonym: CHI 621
Target: Interleukin
Nedocromil
Cat.No: T16280
Synonym: FPL 59002,尼多克罗
Target: Leukotriene Receptor, Prostaglandin Receptor, Histamine Receptor
Fezakinumab
Cat.No: T76775
Synonym: ILV 094
Target: Interleukin
HBX 41108
Cat.No: T21527
Synonym: HBX-41108,7-氯-9-氧代-9H-茚并[1,2-B]吡嗪-2,3-二甲腈
Target: DUB, p53
7-Methoxy-1-naphthaleneacetic acid
Cat.No: T9897
Synonym:
Target: Others
AP23846
Cat.No: T68455
Synonym: AP-23846
Target: Src
IRAK4-IN-4
Cat.No: T11673
Synonym:
Target: IRAK, cGAS
SDZ 224-015
Cat.No: T36534
Synonym: SDZ 224015
Target: IL Receptor, Caspase
GS143
Cat.No: T25465
Synonym: GS-143,GS 143
Target: IκB/IKK, E1/E2/E3 Enzyme, NF-κB
Benralizumab
Cat.No: T10497
Synonym: BIW-8405,MEDI-563
Target: Apoptosis, IL Receptor, Interleukin
Zimlovisertib
Cat.No: TQ0167
Synonym: PF-06650833,PF06650833
Target: IRAK
CTA 056
Cat.No: T35569
Synonym:
Target: Apoptosis
AZ1495
Cat.No: T14367
Synonym:
Target: IRAK, CDK, Haspin Kinase
Pyrintegrin
Cat.No: T16695
Synonym:
Target: Integrin
Y13g dihydrochloride
Cat.No: T60739L
Synonym: Y13g 2HCl(T60739 Free base)
Target: IL Receptor, AChE
Dupilumab
Cat.No: T13666
Synonym: REGN-668,SAR-231893
Target: IL Receptor
Benzquinamide
Cat.No: T12343
Synonym: BZQ,P2647,Benzoquinamide
Target: Adrenergic Receptor
Tyrphostin 8
Cat.No: T34973
Synonym: 4-Hydroxybenzylidenemalononitrile
Target: EGFR, GTPase
MyD88-IN-1
Cat.No: T77353
Synonym:
Target: IL Receptor, NF-κB, TLR, MyD88
Ixekizumab
Cat.No: T38105
Synonym: LY2439821
Target: IL Receptor, Interleukin
EM 163
Cat.No: T41142
Synonym:
Target: IL Receptor, p38 MAPK, MyD88
Cat. No. Product Name Target Signaling Pathways
TN1702 Glycycoumarin

甘草香豆素

P450; JNK; AMPK; Autophagy Autophagy; Chromatin/Epigenetic; MAPK; Metabolism; PI3K/Akt/mTOR signaling
Glycycoumarin 是甘草中的一种香豆素,能直接靶向 T-LAK 细胞源蛋白激酶发挥抗肝癌活性 。它通过激活自噬,抑制内质网应激介导的 JNK 和 GSK-3 介导的线粒体途径,来抑制肝细胞脂性凋亡。它是一种雌激素激动剂,对 CYP1A2 和 CYP2B6 有中度抑制作用。
T7210 Guanosine 5'-diphosphate

GDP,鸟苷-5ˊ-二磷酸

Endogenous Metabolite Metabolism
Guanosine 5'-diphosphate (GDP) 是核苷二磷酸,是潜在的铁动员剂,能够阻断铁调素-铁转运蛋白相互作用并调节白细胞介素-6 (IL-6)/stat-3 途径。
T19719 TBMP

butylated hydroxyanisole

Others Others
TBMP (butylated hydroxyanisole) 是病毒包膜蛋白血凝素 (HA) 介导的进入新型抑制剂。
TN2246 Swertiajaponin

Tyrosinase Proteases/Proteasome
Swertiajaponin 是酪氨酸酶抑制剂,与酪氨酸酶结合囊形成多个氢键和疏水相互作用,IC50=43.47 μM。它能抑制黑色素积累,具有较强的抗氧化活性。它还能通过抑制氧化应激介导的 MAPK/MITF 信号导致酪氨酸酶蛋白水平下降。
T6S0077 Byakangelicol

COX Immunology/Inflammation; Neuroscience
Byakangelicol 是一种分离自白芷的白三醇,能够抑制环加氧酶-2的表达及活性,从而减少白细胞介素-1β诱导的 A549 细胞中前列腺素 E2 的释放。它可用于研究气道炎症。
T1273 Diacerein

双醋瑞因,Diacerhein,Fisiodar,Diacetylrhein

IL Receptor; Interleukin Immunology/Inflammation
Diacerein (Fisiodar) 是一种慢效具有白介素-1β 抑制效果的蒽醌类化合物。
T2924 Phloretin

根皮素,Dihydronaringenin,NSC 407292,RJC 02792

SGLT; transporter; Endogenous Metabolite GPCR/G Protein; Metabolism
Phloretin (NSC-407292) 是从苹果树叶中提取的一种查耳酮,具有抗炎、抗氧化和抗癌活性。它是真核尿素转运蛋白抑制剂,可阻断 VacA 介导的尿素和离子转运,有潜力用于类风湿性关节炎和过敏性气道炎症的相关研究。
TN5171 Tricetin

Apoptosis; Others; Nrf2 Apoptosis; Immunology/Inflammation; Others
Tricetin 是一种从石榴中分离出的类黄酮。Tricetin 是 Keap1-Nrf2 蛋白相互作用(PPI)的强效竞争性抑制剂,通过激活 Nrf2/HO-1 信号通路和阻止线粒体依赖性细胞凋亡通路,保护帕金森病患免受 6-OHDA 诱导的神经毒性的影响。Tricetin 通过 Akt/GSK-1β途径抑制鼻咽癌的迁移和指示性蛋白酶早老素-1(PS-1)表达。Tricetin 抑制由Egr-1介导的氧化LDL 诱导的内皮炎症,保护大鼠软骨细胞免受IL-1β诱导的炎症和细胞凋亡。
T38373 2-heptyl-3-hydroxy-4(1H)-Quinolone

2-heptyl-3-hydroxy-4(1H)-Quinolone,PQS,Pseudomonas Quinolone Signal

Others Others
2-heptyl-3-hydroxy-4(1H)-Quinolone (Pseudomonas Quinolone Signal) 是一种铜绿假单胞菌为应对细胞密度增加而产生的一种法定人数感应信号分子。 它增加了铜绿假单胞菌中lasB 基因的表达,增加代谢物焦蓝蛋白和凝集素PA-IL 的分泌,以及增加铜绿假单胞菌种群的生物膜生产。当使用浓度为40 μM 时,它还会降低铜绿假单胞菌生长介质中的铁含量,并在硫酸铁溶液中充当一种铁螯合剂。
T79941 Antimycin A2c

Apoptosis Apoptosis
Anticanceragent 141(compound AE)是一种针对HPV感染宫颈癌具有抑制作用的抗霉素生物碱。该化合物能够抑制宫颈癌HeLa细胞的增殖并导致细胞周期在S期停滞。Anticanceragent 141破坏线粒体功能,诱导caspase依赖性细胞凋亡,并激活ROS介导的泛素依赖性蛋白酶体系统,进而引起E6/E7癌蛋白的降解。
TN5153 Torilin

MMP; ERK; IκB/IKK; p38 MAPK; NF-κB; Tyrosinase; Reductase; DNA/RNA Synthesis; JNK Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Endocrinology/Hormones; MAPK; Metabolism; NF-κB; Proteases/Proteasome
Torilin 是一种睾酮5α还原酶抑制剂,它(IC50=31.7+/-4.23μM)对5α还原酶的抑制作用强于α-亚麻酸(IC50=160.3+/-24.62μM),但弱于非那雄胺(IC50=0.38+/-0.06μM)。Torilin 具有免疫调节、肝脏保护和抗炎特性,它通过限制 TAK1介导的 MAP 激酶和 NF-βB 活化来抑制炎症,它可以减轻关节炎的严重程度,改变 dLN 或关节中的白细胞活化,并恢复血清和脾细胞细胞因子失衡。托利林抑制α-黑素细胞刺激激素激活的 B16黑色素瘤细胞中的黑色素生成,IC(50)值为25μM。Torilin 对枯草芽孢杆菌 ATCC 6633孢子和营养细胞表现出优异的抗菌活性。Torilin 在体内和体外都具有强大的抗血管生成活性,它可能通过抑制肿瘤侵袭来抑制肿瘤发生,逆转癌细胞的多药耐药性,它可以增强阿霉素、长春碱、紫杉醇和秋水仙碱对多药耐药 KB-V1和 MCF7/ADR 细胞的细胞毒性。

天然产物

Glycycoumarin
Cat.No: TN1702
Synonym: 甘草香豆素
Target: P450, JNK, AMPK, Autophagy
Guanosine 5'-diphosphate
Cat.No: T7210
Synonym: GDP,鸟苷-5ˊ-二磷酸
Target: Endogenous Metabolite
TBMP
Cat.No: T19719
Synonym: butylated hydroxyanisole
Target: Others
Swertiajaponin
Cat.No: TN2246
Synonym:
Target: Tyrosinase
Byakangelicol
Cat.No: T6S0077
Synonym:
Target: COX
Diacerein
Cat.No: T1273
Synonym: 双醋瑞因,Diacerhein,Fisiodar,Diacetylrhein
Target: IL Receptor, Interleukin
Phloretin
Cat.No: T2924
Synonym: 根皮素,Dihydronaringenin,NSC 407292,RJC 02792
Target: SGLT, transporter, Endogenous Metabolite
Tricetin
Cat.No: TN5171
Synonym:
Target: Apoptosis, Others, Nrf2
2-heptyl-3-hydroxy-4(1H)-Quinolone
Cat.No: T38373
Synonym: 2-heptyl-3-hydroxy-4(1H)-Quinolone,PQS,Pseudomonas Quinolone Signal
Target: Others
Antimycin A2c
Cat.No: T79941
Synonym:
Target: Apoptosis
Torilin
Cat.No: TN5153
Synonym:
Target: MMP, ERK, IκB/IKK, p38 MAPK, NF-κB, Tyrosinase, Reductase, DNA/RNA Synthesis, JNK
Cat. No. Product Name Species Expression System
TMPY-03298 IL-6 Protein, Rat, Recombinant

白细胞介素,interleukin 6,白介素

Rat E. coli
Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affini...
TMPY-02789 IL-33 Protein, Canine, Recombinant

白介素,interleukin 33,白细胞介素

Canine E. coli
Interleukin 33 (IL-33), also known as DVS27 or NF-HEV (Nuclear Factor from High Endothelial Venules), is a pro-inflammatory protein and a chromatin-associated cytokine of the IL-1 family with high sequence and structural similarity to IL-1 and IL-18. IL-33 protein is expressed highly and rather selectively by high endothelial venule endothelial cells (HEVECs) in human tonsils, Peyer's patches, and lymph nodes. IL-33 protein has transcriptional regulatory properties, and the researches suggested ...
TMPY-05523 IL-31 Protein, Cynomolgus, Recombinant (His)

白介素,白细胞介素,interleukin 31

Cynomolgus HEK293
IL-31 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 cells.
TMPY-01940 IL-31 Protein, Mouse, Recombinant (His)

白细胞介素,interleukin 31,1700013B14Rik,白介素

Mouse HEK293
IL-31 Protein, Mouse, Recombinant (His) is expressed in HEK293 cells.
TMPY-02457 IL-2 Protein, Rat, Recombinant

interleukin 2,白细胞介素,白介素

Rat E. coli
Interleukin-2, also known as a T-cell growth factor, TCGF, Aldesleukin, and IL2, is a secreted protein that belongs to the IL-2 family. Interleukin-2 / IL-2 was the first interleukin molecule to be discovered. Interleukin-2 / IL-2 molecule was first purified to homogeneity by immunoaffinity chromatography by Kendall Smith and his team at Dartmouth Medical School. Interleukin-2 / IL-2 was also the first cytokine shown to mediate its effects via a specific IL-2 receptor, and it was also the first ...
TMPY-00982 IL-13 Protein, Cynomolgus, Recombinant

白介素,interleukin 13,白细胞介素

Cynomolgus HEK293
Interleukin 13 (IL-13) is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. IL-13 protein is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL-13 Rα1 and IL-13 Rα2). As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses, and disease...
TMPY-03327 IL-6 Protein, Rhesus, Recombinant

白介素,interleukin 6,白细胞介素

Rhesus E. coli
Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affini...
TMPY-01928 IL-18 Protein, Rhesus, Recombinant (His)

白细胞介素,interleukin 18,白介素

Rhesus E. coli
Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its bi...
TMPY-05449 IL-33 Protein, Cynomolgus, Recombinant

白细胞介素,interleukin 33,白介素

Cynomolgus E. coli
Interleukin 33 (IL-33), also known as DVS27 or NF-HEV (Nuclear Factor from High Endothelial Venules), is a pro-inflammatory protein and a chromatin-associated cytokine of the IL-1 family with high sequence and structural similarity to IL-1 and IL-18. IL-33 protein is expressed highly and rather selectively by high endothelial venule endothelial cells (HEVECs) in human tonsils, Peyer's patches, and lymph nodes. IL-33 protein has transcriptional regulatory properties, and the researches suggested ...
TMPY-03238 IL-6 Protein, Mouse, Recombinant

白介素,Il-6,白细胞介素,interleukin 6

Mouse E. coli
Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affini...
TMPY-04212 IL-16 Protein, Mouse, Recombinant (His)

白介素,interleukin 16,mKIAA4048,白细胞介素

Mouse E. coli
IL-16 Protein, Mouse, Recombinant (His) is expressed in E. coli with His tag. The predicted molecular weight is 14.5 kDa. Accession number: O54824-1
TMPY-02554 IL-5 Protein, Mouse, Recombinant (His)

白细胞介素,interleukin 5,白介素,Il-5

Mouse Baculovirus-Insect Cells
Interleukin 5 (IL-5) is a member of the interleukin family with a length of 115 amino acids. Interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes) and has been found in a wide variety of body cells. Interleukin 5 or IL-5 is produced by T helper-2 cells and mast cells. It helps to stimulate B cell growth and increase immunoglobulin secretion and is considered a key mediator in eosinophil activation. Int...
TMPY-05064 IL-10 Protein, Mouse, Recombinant

白介素,白细胞介素,CSIF,interleukin 10,Il-10

Mouse E. coli
IL-10 is an anti-inflammatory cytokine that belongs to the IL-10 family. It is produced by a variety of cell lines, including T-cells, macrophages, mast cells, and other cell types, while it is produced primarily by monocytes and to a lesser extent by lymphocytes. IL-10 is mainly expressed in monocytes and Type 2 T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and also in a certain subset of activated T cells and B cells. IL-10 has pleiotropic effects in immunoregulation an...
TMPY-03273 IL-18 Protein, Mouse, Recombinant

interleukin 18,白细胞介素,白介素,Il-18,Igif

Mouse E. coli
Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its bi...
TMPJ-00575 IL-13 Protein, Human, Recombinant (His)

Interleukin-13,IL-13,白介素,白细胞介素

Human Human Cells
Interleukin-13 is also known as IL-13. It is a protein that in humans is encoded by the IL13 gene. Interleukin-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells.It is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokin...
TMPY-03526 IL-23 Protein, Mouse, Recombinant (His)

IL-23,白细胞介素,p19,白介素

Mouse HEK293
IL-23 Protein, Mouse, Recombinant (His) is expressed in HEK293 cells.
TMPY-02445 IL-1 beta/IL-1F2 Protein, Rhesus, Recombinant

interleukin 1, beta,IL-1 β,白介素,interleukin 1, β,白细胞...

Rhesus E. coli
Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishme...
TMPY-02227 IL-1 beta/IL-1F2 Protein, Rat, Recombinant (mature form)

白细胞介素,interleukin 1, beta,白介素,interleukin 1, β,IL-1...

Rat E. coli
Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishme...
TMPY-02788 IL-2 Protein, Mouse, Recombinant

Il-2,白细胞介素,interleukin 2,白介素

Mouse E. coli
Interleukin-2, also known as a T-cell growth factor, TCGF, Aldesleukin, and IL2, is a secreted protein that belongs to the IL-2 family. Interleukin-2 / IL-2 was the first interleukin molecule to be discovered. Interleukin-2 / IL-2 molecule was first purified to homogeneity by immunoaffinity chromatography by Kendall Smith and his team at Dartmouth Medical School. Interleukin-2 / IL-2 was also the first cytokine shown to mediate its effects via a specific IL-2 receptor, and it was also the first ...
TMPY-03123 IL-13 Protein, Mouse, Recombinant

白细胞介素,Il-13,白介素,interleukin 13

Mouse HEK293
Interleukin 13 (IL-13) is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. IL-13 protein is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL-13 Rα1 and IL-13 Rα2). As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses, and disease...
TMPJ-00059 IL-7 Protein, Human, Recombinant (His)

Interleukin-7,IL7,白细胞介素,IL-7,白介素

Human Human Cells
Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-spe...
TMPY-04107 IL-31 Protein, Human, Recombinant (His)

interleukin 31,白介素,白细胞介素,IL-31

Human HEK293
IL-31 Protein, Human, Recombinant (His) is expressed in HEK293 cells.
TMPY-04632 IL-15 Protein, Human, Recombinant

白细胞介素,IL-15,白介素,interleukin 15

Human E. coli
The protein encoded by the IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietic receptor subunits and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as ...
TMPY-03942 IL-36 gamma Protein, Mouse, Recombinant (His)

interleukin 36, γ,IL36 γ,IL36g,Il1f9,interleukin 36, gamma,白...

Mouse E. coli
IL-36 gamma Protein, Mouse, Recombinant (His) is expressed in E. coli.
TMPY-04178 IL-11 Protein, Mouse, Recombinant

IL-11,interleukin 11,白细胞介素,白介素

Mouse E. coli
IL11 is a multifunctional cytokine first isolated in 199 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 is also known under the names adipogenesis inhibitory factor (AGIF) and oprelvekin. IL11 can improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute-phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell prolifer...
TMPY-03915 IL-5 Protein, Human, Recombinant

TRF,白介素,EDF,interleukin 5,IL-5,白细胞介素

Human E. coli
Interleukin 5 (IL-5) is a member of the interleukin family with a length of 115 amino acids. Interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes) and has been found in a wide variety of body cells. Interleukin 5 or IL-5 is produced by T helper-2 cells and mast cells. It helps to stimulate B cell growth and increase immunoglobulin secretion and is considered a key mediator in eosinophil activation. Int...
TMPY-02558 IL-4 Protein, Mouse, Recombinant

白介素,白细胞介素,BSF-1,Il-4,interleukin 4

Mouse E. coli
IL-4 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13.4 kDa and the accession number is P07750.
TMPY-03488 IL-11 Protein, Human, Recombinant

白细胞介素,interleukin 11,IL-11,白介素,AGIF

Human E. coli
IL11 is a multifunctional cytokine first isolated in 199 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 is also known under the names adipogenesis inhibitory factor (AGIF) and oprelvekin. IL11 can improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute-phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell prolifer...
TMPY-01963 IL-21 Protein, Human, Recombinant

CVID11,IL-21,白介素,白细胞介素,Za11,interleukin 21

Human E. coli
IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the i...
TMPY-03383 IL-7 Protein, Human, Recombinant

IL-7,interleukin 7,Interleukin-7,白介素,白细胞介素

Human E. coli
IL7, also known as interleukin 7, is a hematopoietic growth factor that belongs to the IL-7/IL-9 family. It is secreted by stromal cells in the bone marrow and thymus. IL7 stimulates the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. IL7 and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. It is found to be a cofactor for V(D)J rearrangement of the T cell recep...
TMPY-05576 IL-5 Protein, Human, Recombinant (His)

白细胞介素,白介素,EDF,TRF,interleukin 5,IL-5

Human HEK293
Interleukin 5 (IL-5) is a member of the interleukin family with a length of 115 amino acids. Interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes) and has been found in a wide variety of body cells. Interleukin 5 or IL-5 is produced by T helper-2 cells and mast cells. It helps to stimulate B cell growth and increase immunoglobulin secretion and is considered a key mediator in eosinophil activation. Int...
TMPY-02241 IL-16 Protein, Human, Recombinant (His)

LCF,prIL-16,白介素,NIL16,白细胞介素,interleukin 16,PRIL16

Human E. coli
IL-16 Protein, Human, Recombinant (His) is expressed in E. coli with His tag. The predicted molecular weight is 15.3 kDa. Accession number: AAC12732.1
TMPY-04845 IL-3 Protein, Mouse, Recombinant

Il-3,白介素,PSF,HCGF,BPA,白细胞介素,MCGF,Csfmu,interleukin ...

Mouse HEK293
IL3 (interleukin 3), also known as IL-3, is a potent growth-promoting cytokine that belongs to the IL-3 family. IL3/IL-3 also belongs to the group of interleukins. Interleukins are produced by a wide variety of body cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well ...
TMPY-01993 IL-13 Protein, Human, Recombinant

IL-13,P600,interleukin 13,ALRH,白介素,白细胞介素

Human CHO
Interleukin 13 (IL-13) is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. IL-13 protein is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL-13 Rα1 and IL-13 Rα2). As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses, and disease...
TMPY-02134 IL-1 beta/IL-1F2 Protein, Mouse, Recombinant

Il-1b,IL-1beta,白细胞介素,interleukin 1, β,interleukin 1, beta,IL...

Mouse E. coli
Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishme...
TMPY-00297 IL-3 Protein, Human, Recombinant(aa 20-152)

interleukin 3,白介素,白细胞介素,Interleukin-3,IL-3,MCGF,MUL...

Human E. coli
IL3 (interleukin 3), also known as IL-3, is a potent growth-promoting cytokine that belongs to the IL-3 family. IL3/IL-3 also belongs to the group of interleukins. Interleukins are produced by a wide variety of body cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well ...
TMPY-02959 IL-20 Protein, Human, Recombinant

ZCYTO10,interleukin-20,IL10D,白细胞介素,interleukin 20,白介素

Human E. coli
IL20/Interleukin-20 belongs to the IL-10 family. It is a cytokine structurally related to interleukin 10. IL20/Interleukin-20 can be detected in skin, trachea, and other tissues. It is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells. It has been shown that interleukin-20 transduces its signal through signal transducer and activator of transcription 3 (STAT3) in...
TMPY-01870 IL-9 Protein, Human, Recombinant (His)

P40,interleukin 9,HP40,白细胞介素,IL-9,白介素

Human Baculovirus-Insect Cells
Interleukin 9, also known as IL-9, is a cytokine (cell signaling molecule) belonging to the group of interleukins. IL-9 is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL-9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. Genetic studies on a mouse model of asth...
TMPY-00840 IL-13 Protein, Human, Recombinant (hFc)

IL-13,白介素,白细胞介素,ALRH,interleukin 13,P600

Human HEK293
Interleukin 13 (IL-13) is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. IL-13 protein is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL-13 Rα1 and IL-13 Rα2). As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses, and disease...
TMPY-01845 IL-10 Protein, Human, Recombinant (His)

GVHDS,TGIF,CSIF,interleukin 10,IL-10,Interleukin-10,IL10A,白细...

Human HEK293
IL-10 is an anti-inflammatory cytokine that belongs to the IL-10 family. It is produced by a variety of cell lines, including T-cells, macrophages, mast cells, and other cell types, while it is produced primarily by monocytes and to a lesser extent by lymphocytes. IL-10 is mainly expressed in monocytes and Type 2 T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and also in a certain subset of activated T cells and B cells. IL-10 has pleiotropic effects in immunoregulation an...
TMPY-00136 IL-29 Protein, Human, Recombinant

interferon, λ1,IL-29,IL29,interferon, lambda 1,IFNL1,白介素...

Human HEK293
Interleukin-29 (IL-29), also known as cytokine Zcyto21, Interferon lambda-1, IFN-lambda-1, and IFNL1, is a secreted protein that belongs to the IL-28 / IL-29 family. IL-29 is a cytokine with immunomodulatory activity. IL-29 is highly similar in amino acid sequence to the IL-28. IL-28 and IL-29 are induced by a viral infection and showed antiviral activity. IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10Rbeta) and an orphan c...
TMPY-03153 IL-27 Protein, Mouse, Recombinant (His)

p28,Il30,IL-27,白介素,interleukin 27,IL-27p28,白细胞介素

Mouse HEK293
IL-27 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.5 kDa and the accession number is O35228&Q8K3I6.
TMPY-00861 IL-33 Protein, Human, Recombinant

IL1F11,C9orf26,NFEHEV,NF-HEV,DVS27,白介素,interleukin ...

Human E. coli
Interleukin 33 (IL-33), also known as DVS27 or NF-HEV (Nuclear Factor from High Endothelial Venules), is a pro-inflammatory protein and a chromatin-associated cytokine of the IL-1 family with high sequence and structural similarity to IL-1 and IL-18. IL-33 protein is expressed highly and rather selectively by high endothelial venule endothelial cells (HEVECs) in human tonsils, Peyer's patches, and lymph nodes. IL-33 protein has transcriptional regulatory properties, and the researches suggested ...
TMPY-03142 IL-27 Protein, Human, Recombinant (His)

IL27p28,IL-27,白介素,IL27A,interleukin 27,p28,白细胞介素,IL...

Human CHO
IL-27 protein is a member of the IL-6 superfamily, which is expressed on monocytes, endothelial cells, and dendritic cells. IL-27 protein is also referred to as the IL-12 p35-related protein, p28, is one subunit of a heterodimeric cytokine complex, and associates with another subunit EBI3 (EBV-induced gene 3), and IL-12 p40-related protein (IL-27B). IL-27 protein is an early product of activated antigen-presenting cells and drives the rapid clonal expansion of naive CD4(+) T cells and plays a ro...
TMPY-05648 IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated

IL23,IL-23,白细胞介素,白介素,P19,IL23P19,SGRF,IL-23A

Human HEK293
IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 with His and AVI tag. The predicted molecular weight is 57.6 kDa. Accession number: NP_002178.2&NP_057668.1
TMPY-03547 IL-10 Protein, Human, Recombinant

Interleukin-10,TGIF,CSIF,IL10A,IL-10,白介素,白细胞介素,GVHD...

Human E. coli
IL-10 is an anti-inflammatory cytokine that belongs to the IL-10 family. It is produced by a variety of cell lines, including T-cells, macrophages, mast cells, and other cell types, while it is produced primarily by monocytes and to a lesser extent by lymphocytes. IL-10 is mainly expressed in monocytes and Type 2 T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and also in a certain subset of activated T cells and B cells. IL-10 has pleiotropic effects in immunoregulation an...
TMPY-02900 IL-17A Protein, Mouse, Recombinant

IL-17A,Ctla8,Ctla-8,interleukin 17A,Il17,白介素,白细胞介素,...

Mouse E. coli
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocyt...
TMPJ-01463 IL-2 Protein, Human, Recombinant (E. coli)

Aldesleukin,IL-2,IL2,T-Cell Growth Factor,TCGF,白细胞介素,白介素...

Human E. coli
IL-2 Protein, Human, Recombinant (E. coli) is expressed in E. coli expression system. The accession number is P60568.
TMPY-02886 IL-17A Protein, Human, Recombinant

IL-17,白细胞介素,interleukin 17A,CTLA8,白介素,IL17,IL-17A,C...

Human E. coli
IL-17A Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.7 kDa and the accession number is Q16552.
TMPY-02350 IL-12 Protein, Mouse, Recombinant (His)

Il-12b,p35,IL-12p35,Ll12a,Il-12a,interleukin 12A,Il12p40,白细胞...

Mouse HEK293
IL-12 Protein, Mouse, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 60.3 kDa. Accession number: P43431&P43432
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重组蛋白

IL-6 Protein, Rat, Recombinant
Cat.No: TMPY-03298
Species: Rat
Expression System: E. coli
IL-33 Protein, Canine, Recombinant
Cat.No: TMPY-02789
Species: Canine
Expression System: E. coli
IL-31 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPY-05523
Species: Cynomolgus
Expression System: HEK293
IL-31 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01940
Species: Mouse
Expression System: HEK293
IL-2 Protein, Rat, Recombinant
Cat.No: TMPY-02457
Species: Rat
Expression System: E. coli
IL-13 Protein, Cynomolgus, Recombinant
Cat.No: TMPY-00982
Species: Cynomolgus
Expression System: HEK293
IL-6 Protein, Rhesus, Recombinant
Cat.No: TMPY-03327
Species: Rhesus
Expression System: E. coli
IL-18 Protein, Rhesus, Recombinant (His)
Cat.No: TMPY-01928
Species: Rhesus
Expression System: E. coli
IL-33 Protein, Cynomolgus, Recombinant
Cat.No: TMPY-05449
Species: Cynomolgus
Expression System: E. coli
IL-6 Protein, Mouse, Recombinant
Cat.No: TMPY-03238
Species: Mouse
Expression System: E. coli
IL-16 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-04212
Species: Mouse
Expression System: E. coli
IL-5 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-02554
Species: Mouse
Expression System: Baculovirus-Insect Cells
IL-10 Protein, Mouse, Recombinant
Cat.No: TMPY-05064
Species: Mouse
Expression System: E. coli
IL-18 Protein, Mouse, Recombinant
Cat.No: TMPY-03273
Species: Mouse
Expression System: E. coli
IL-13 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00575
Species: Human
Expression System: Human Cells
IL-23 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-03526
Species: Mouse
Expression System: HEK293
IL-1 beta/IL-1F2 Protein, Rhesus, Recombinant
Cat.No: TMPY-02445
Species: Rhesus
Expression System: E. coli
IL-1 beta/IL-1F2 Protein, Rat, Recombinant (mature form)
Cat.No: TMPY-02227
Species: Rat
Expression System: E. coli
IL-2 Protein, Mouse, Recombinant
Cat.No: TMPY-02788
Species: Mouse
Expression System: E. coli
IL-13 Protein, Mouse, Recombinant
Cat.No: TMPY-03123
Species: Mouse
Expression System: HEK293
IL-7 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00059
Species: Human
Expression System: Human Cells
IL-31 Protein, Human, Recombinant (His)
Cat.No: TMPY-04107
Species: Human
Expression System: HEK293
IL-15 Protein, Human, Recombinant
Cat.No: TMPY-04632
Species: Human
Expression System: E. coli
IL-36 gamma Protein, Mouse, Recombinant (His)
Cat.No: TMPY-03942
Species: Mouse
Expression System: E. coli
IL-11 Protein, Mouse, Recombinant
Cat.No: TMPY-04178
Species: Mouse
Expression System: E. coli
IL-5 Protein, Human, Recombinant
Cat.No: TMPY-03915
Species: Human
Expression System: E. coli
IL-4 Protein, Mouse, Recombinant
Cat.No: TMPY-02558
Species: Mouse
Expression System: E. coli
IL-11 Protein, Human, Recombinant
Cat.No: TMPY-03488
Species: Human
Expression System: E. coli
IL-21 Protein, Human, Recombinant
Cat.No: TMPY-01963
Species: Human
Expression System: E. coli
IL-7 Protein, Human, Recombinant
Cat.No: TMPY-03383
Species: Human
Expression System: E. coli
IL-5 Protein, Human, Recombinant (His)
Cat.No: TMPY-05576
Species: Human
Expression System: HEK293
IL-16 Protein, Human, Recombinant (His)
Cat.No: TMPY-02241
Species: Human
Expression System: E. coli
IL-3 Protein, Mouse, Recombinant
Cat.No: TMPY-04845
Species: Mouse
Expression System: HEK293
IL-13 Protein, Human, Recombinant
Cat.No: TMPY-01993
Species: Human
Expression System: CHO
IL-1 beta/IL-1F2 Protein, Mouse, Recombinant
Cat.No: TMPY-02134
Species: Mouse
Expression System: E. coli
IL-3 Protein, Human, Recombinant(aa 20-152)
Cat.No: TMPY-00297
Species: Human
Expression System: E. coli
IL-20 Protein, Human, Recombinant
Cat.No: TMPY-02959
Species: Human
Expression System: E. coli
IL-9 Protein, Human, Recombinant (His)
Cat.No: TMPY-01870
Species: Human
Expression System: Baculovirus-Insect Cells
IL-13 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00840
Species: Human
Expression System: HEK293
IL-10 Protein, Human, Recombinant (His)
Cat.No: TMPY-01845
Species: Human
Expression System: HEK293
IL-29 Protein, Human, Recombinant
Cat.No: TMPY-00136
Species: Human
Expression System: HEK293
IL-27 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-03153
Species: Mouse
Expression System: HEK293
IL-33 Protein, Human, Recombinant
Cat.No: TMPY-00861
Species: Human
Expression System: E. coli
IL-27 Protein, Human, Recombinant (His)
Cat.No: TMPY-03142
Species: Human
Expression System: CHO
IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-05648
Species: Human
Expression System: HEK293
IL-10 Protein, Human, Recombinant
Cat.No: TMPY-03547
Species: Human
Expression System: E. coli
IL-17A Protein, Mouse, Recombinant
Cat.No: TMPY-02900
Species: Mouse
Expression System: E. coli
IL-2 Protein, Human, Recombinant (E. coli)
Cat.No: TMPJ-01463
Species: Human
Expression System: E. coli
IL-17A Protein, Human, Recombinant
Cat.No: TMPY-02886
Species: Human
Expression System: E. coli
IL-12 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-02350
Species: Mouse
Expression System: HEK293
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