Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nedocromil (FPL 59002) 对多种介质的作用或形成有抑制作用,包括组胺,前列腺素 D2和白三烯 C4。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 283 | 现货 | ||
5 mg | ¥ 659 | 现货 | ||
10 mg | ¥ 995 | 现货 | ||
25 mg | ¥ 2,160 | 现货 | ||
50 mg | ¥ 3,490 | 现货 | ||
100 mg | ¥ 4,970 | 现货 | ||
200 mg | ¥ 7,210 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 728 | 现货 |
产品描述 | Nedocromil (FPL 59002) inhibits the action or formation of multiple mediators. Which including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2). |
靶点活性 | LTC4:2.3 μM(IC30), PGD2:1.9 μM(IC30), histamine:2.1 μM(IC30) |
体外活性 | Nedocromil suppresses the release of histamine, LTC4, and PGD2 from mast cells challenged with antigen with IC30 values of 2.1 μM, 2.3 μM, and 1.9 μM, respectively. It also has anti-human IgE with IC30 values of 4.7 μM, 1.3 μM, and 1.3 μM, respectively[1]. |
体内活性 | Nedocromil can obviously improve cardiac function in mice with diabetic cardiomyopathy, but the treatment cannot restore normal function. Nedocromil-treated diabetic mice display obviously improved heart function compared with controls. However, the cardiac function of Nedocromil-treated diabetic mice remains significantly impaired when compared with normal mice [2]. |
别名 | FPL 59002, 尼多克罗 |
分子量 | 371.34 |
分子式 | C19H17NO7 |
CAS No. | 69049-73-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 16.67 mg/mL (44.89 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.6929 mL | 13.4647 mL | 26.9295 mL | 67.3237 mL |
5 mM | 0.5386 mL | 2.6929 mL | 5.3859 mL | 13.4647 mL | |
10 mM | 0.2693 mL | 1.3465 mL | 2.6929 mL | 6.7324 mL | |
20 mM | 0.1346 mL | 0.6732 mL | 1.3465 mL | 3.3662 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Nedocromil 69049-73-6 GPCR/G Protein Immunology/Inflammation Neuroscience Leukotriene Receptor Prostaglandin Receptor Histamine Receptor FPL 59002 FPL59002 Inhibitor inhibit FPL-59002 尼多克罗 inhibitor