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1611

抑制剂 & 化合物

42

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T13491	Neuromuscular-targeting compound 1	Others	Others
	Neuromuscular-targeting compound 1 可用于研究肌肉萎缩和神经肌肉相关疾病。
T13572	Cancer-Targeting Compound 1	Others	Others
	Cancer-Targeting Compound 1可用于激素相关癌症的研究，包括治疗或预防肌瘤、子宫平滑肌瘤、多囊卵巢综合征或激素依赖性癌等等。
T10071	Itch-Targeting Compound 1	Others	Others
	Itch-Targeting Compound 1是一种止痒化合物，对昆虫叮咬的反应、对环境过敏原的反应、皮肤感染、外部恶臭或肾透析患者发生的瘙痒均可有效预防或治疗。
T13900	Arrhythmic-Targeting Compound 1	Others	Others
	Arrhythmic-Targeting Compound 1 is used for arrhythmic disease, with nitrogen-containing spirocycles.
T13573	Arrhythmias-Targeting Compound 1	Others	Others
	Arrhythmias-Targeting Compound 1 is a compound. It is used in the research of arrhythmias.
T13486	Neurodegenerative Disorder-Targeting Compound 1	Others	Others
	Neurodegenerative Disorder-Targeting Compound 1 是一种靶向 calpain 的抑制剂。
T10059	Neuromuscular Disorder-Targeting Compound 1	Others	Others
	Neuromuscular Disorder-Targeting Compound 1 is a compound used in the research of neuromuscular disorders, for example, symptoms of chronic fatigue syndrome and fibromyalgia syndrome.
T19417	Urinary Incontinence-Targeting Compound 1	Others	Others
	Urinary Incontinence-Targeting Compound 1, used in the research of urinary incontinence, is a sulfonanilide derivative.
T83724	TPP-1 hydrochloride Targeting PD-L1 Peptide
	TPP-1是一种针对程序化细胞死亡蛋白1(PD-1)及其配体PD-1配体(PD-L1)之间蛋白-蛋白相互作用的肽抑制剂。它在无细胞实验中结合到PD-L1(Kd = 94.67 nM)。TPP-1 (20 µM)能逆转PD-L1在抗CD3激活的人类CD4+ T细胞中所引起的干扰素γ(IFN-γ)水平的下降。在使用HL-60白血病细胞与抗CD3激活的人类CD4+ T细胞共培养并在植入前预处理时，以4 mg/kg的剂量给药，可减少小鼠异种移植模型中的肿瘤体积。
T83857	Soluble Epoxide Hydrolase PROTAC 1a sEH Proteolysis-targeting Chimera 1a,Soluble Epoxide Hydrolase Proteolysis-targeting Chimera 1a,sEH PROTAC 1a
	Soluble epoxide hydrolase (sEH) PROTAC 1a是一种利用蛋白质降解靶向嵌合体(PROTAC)技术，通过连接区域将cereblon配体1与sEH抑制剂t-TUCB结合。该化合物通过促进sEH的降解，特异性抑制sEH的水解酶活性(IC50 = 0.8 nM)，相较于其磷酸酶活性(IC50 = >10,000 nM)具有较高选择性。sEH PROTAC 1a还特定促进细胞质中而非过氧体中的sEH降解，并通过溶酶体而非蛋白酶体实现其降解。它能够降低thapsigargin诱导的HepG2与293T细胞中磷酸化的inositol-requiring enzyme 1α (IRE1α)水平和X-box结合蛋白1 (XBP1)剪接，表明能减少ER应激。
T83527	(Rac)-Neurodegenerative Disorder-Targeting Compound 1
	(Rac)-Neurodegenerative Disorder-Targeting Compound 1为一种针对神经退行性疾病的化合物，具有calpain抑制活性。
T76218	Targeting the bacterial sliding clamp peptide 46
	Targeting bacterial sliding clamp peptide 46是一种抗菌肽，专门针对细菌的滑动夹蛋白(SC)而设计，其功能是阻断SC依赖的DNA合成作用。
T60015	TSPO ligand-2 Carbonic acid	AUTACs	PROTAC
	TSPO ligand-2 (Carbonic acid) 是 AUTAC1 的配体，AUTAC1含有一个对氟苄基鸟嘌呤和一个烟曲霉醇部分。
T11249L	Dxd Exatecan derivative for ADC,OQM5SD32BQ,UNII-OQM5SD32BQ	Topoisomerase	DNA Damage/DNA Repair
	Dxd (OQM5SD32BQ) 是一种有效的DNA 拓扑异构酶 I 抑制剂，IC50值为 0.31 μM，用作HER2靶向ADC 的偶联药物。
T22282	Brr2-IN-3 Brr2 Inhibitor 9,Brr2 Inhibitor C9	Others	Others
	Brr2-IN-3 (Brr2 Inhibitor C9) 是选择性 Brr2解旋酶变构抑制剂。它呈剂量依赖性地抑制解旋酶(IC50:1.3 μM)。
T18893	5(6)-Carboxyfluorescein 5(6)-羧基荧光素,5-(and-6)-Carboxyfluorescein mixed isomers,5(6)-FAM	Others	Others
	5(6)-Carboxyfluorescein (5-(and-6)-Carboxyfluorescein mixed isomers) 是一种胺反应性 pH 敏感的绿色荧光标记物，能够标记蛋白质、多肽和氨基酸，可用于体内实验检测肿瘤位置。
T6804	Chetomin Chaetomin,NSC289491,BRN0077366	Apoptosis; HSP; HIF	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism
	Chetomin (BRN0077366) 是球毛壳菌的活性成分，是一种无毒的非小细胞肺癌干细胞靶向分子。它是一种热休克蛋白90/缺氧诱导因子1α 途径的抑制剂。
T39370	tri-GalNAc-COOH	LYTACs	PROTAC
	Tri-GalNAc-COOH is a ligand for the asialoglycoprotein receptor (ASGPR) commonly employed in Lysosome Targeting Chimera (LYTAC) investigations.
T6409	ALK kinase inhibitor-1 SAR348830	Others	Others
	SAR348830 是间变性淋巴瘤激酶ALK 抑制剂。
T5374	NAcM-OPT	E1/E2/E3 Enzyme; NEDD8	Metabolism; Ubiquitination
	NAcM-OPT 是口服活性、有效的 cullin neddylation 1 抑制剂，可以抑制 DCN1-UBE2M 相互作用。
T60075	Dopamine D2 receptor agonist-2 Dopamine D2 Receptor	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Dopamine D2 receptor agonist-2 (Dopamine D2 Receptor) 是靶向多巴胺D2受体的配体。
T10531	BGB-102 JNJ-26483327	EGFR; VEGFR; FLT; Src	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	BGB-102 (JNJ-26483327) 是一种针对FLT3 和 YES1 的激酶抑制剂和针对 EGFR 和 VEGFR3 的拮抗剂，可用于研究黄斑变性和与遗传病与畸形相关的疾病。
T1832	Walrycin B	Antibacterial; Antibiotic	Microbiology/Virology
	Walrycin B 是一种能特异地靶向WalR 应答调节子的新型抗菌素。
T5452	Ehp-inhibitor-2	Ephrin Receptor	Tyrosine Kinase/Adaptors
	Ehp-inhibitor-2 是一种靶向 Eph 受体的 Eph 家族酪氨酸激酶抑制剂。
T5451	Eph inhibitor 2 Ehp-inhibitor-1	Ephrin Receptor	Tyrosine Kinase/Adaptors
	Eph inhibitor 2 是一种 Eph 家族酪氨酸激酶抑制剂。
T9584	UNC6934	Others; Histone Methyltransferase	Chromatin/Epigenetic; Others
	UNC6934 是一种针对 NSD2 的 N 端 PWWP (PWWP1) 结构域的化学探针，可定位核仁。
TNU0123	5-Methoxyuridine Mo5U	Apoptosis	Apoptosis
	5-Methoxyuridine (Mo5U) is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting malignant tumors of the inert lymphatic system and inducing apoptosis.5-Methoxyuridine's anticancer mechanism is dependent on the inhibition of DNA synthesis.5-Methoxyuridine is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting malignant tumors of the inert lymphatic system and inducing apoptosis.
TP2065L	α-Conotoxin PIA acetate	AChR	Neuroscience
	α-Conotoxin PIA acetate 是烟碱型乙酰胆碱受体 (nAChR) 的拮抗剂，主要针对 α6 和 α3 亚基。
T13142L	Theodrenaline hydrochloride Theodrenaline hydrochloride(13460-98-5 Free base)	SARS-CoV	Microbiology/Virology
	Theodrenaline hydrochloride 是一种靶向 SARS-CoV-2 的抑制剂，可用于研究由脊髓麻醉引起的低血压。
T8955	PCNA-I1	Others	Others
	PCNA-I1 是PCNA(增殖细胞核抗原)抑制剂。它能够直接与 PCNA 三聚体结合(Kd:0.41 μM)，在体内外均表现出抗肿瘤活性。
T12257	NSC 146109 hydrochloride	Apoptosis; Others	Apoptosis; Others
	NSC 146109 hydrochloride 是一种靶向 MDMX 的 p53 激活剂。 NSC 146109 hydrochloride 可用于乳腺癌研究。
T20022	Cephalexin monohydrate Cephalexin hydrate,Cephacillin hydrate,Cefalexin hydrate	Antibiotic	Microbiology/Virology
	Cephalexin monohydrate (Cephalexin hydrate) 是一种可口服的半合成头孢菌素类抗生素，具有显著的抗菌活性，通过靶向青霉素结合蛋白 (PBPs)抑制细菌增殖。
T39024	PrNMI	Cannabinoid Receptor	GPCR/G Protein
	PrNMI is a highly effective and orally active agonist targeting the peripherally restricted cannabinoid 1 receptor (CB1R). It exhibits pronounced analgesic properties, efficiently suppressing both chemotherapy-induced peripheral neuropathy pain symptoms and cancer-induced bone pain.
T23777	BCI-137 BCI137	Others	Others
	BCI-137 是 Argonaute 2 配体。它通过靶向 MicroRNA 结合域来发挥作用。
T9383	Pomalidomide-PEG2-OH 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-(2-hydroxyethoxy)ethyl]amino]-	PROTACs	PROTAC
	Pomalidomide-PEG2-OH 能够合成用于靶向蛋白质降解和 PROTAC（蛋白水解靶向嵌合体）技术的分子。
T9384	Pomalidomide-PEG3-OH 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]amino]-	PROTACs	PROTAC
	Pomalidomide-PEG3-OH 能够合成用于靶向蛋白质降解和 PROTAC（蛋白水解靶向嵌合体）技术的分子。
T21807	INCA-6 Triptycene-1,4-quinone	Others	Others
	INCA-6 (Triptycene-1,4-quinone) 是细胞渗透性的 NFAT 抑制剂。INCA-6 通过特异性阻断 NFAT 底物靶向钙调神经磷酸酶位点，有效抑制calcineurin (CN)-NFAT 信号传导。
T38239	2'-Deoxy-2'-fluorouridine
	2'-Deoxy-2'-fluorouridine 是合成抗流感病毒试剂的中间体。
TNU0022	6-Azauridine 6-Azuridine	Apoptosis	Apoptosis
	6-Azauridine (6-Azuridine) is a purine nucleoside analog with a broad spectrum of antitumor activity, targeting malignant tumors of the inert lymphatic system and inducing apoptosis.6-Azuridine's anticancer mechanism is dependent on the inhibition of DNA synthesis.
T9927	Panitumumab	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Panitumumab 是一种重组全人源 IgG2 单克隆抗体，可与表皮生长因子(EGFR)结合，具有抗肿瘤活性。
T41277	PACMA 31	Others	Others
	PACMA 31 是一种不可逆的共价蛋白二硫键异构酶 (PDI) 抑制剂，IC50 为 10 μM。 PACMA 31 显着抑制卵巢肿瘤生长并表现出肿瘤靶向能力。
T4459	PK11000	DNA Alkylator/Crosslinker	DNA Damage/DNA Repair
	PK11000 是一种烷化剂，可通过共价半胱氨酸修饰来稳定野生型和突变型p53的 DNA 结合结构域。
T19826	Rabeprazole LY307640	Potassium Channel; STAT	JAK/STAT signaling; Membrane transporter/Ion channel; Stem Cells
	Rabeprazole (LY307640) 是一种 H+/K+-ATPase 抑制剂，通过靶向 STAT3 介导的糖酵解来抑制胃上皮细胞中的细胞增殖，可用于研究胃溃疡。
T9957	LASV inhibitor 3.3	Virus Protease	Microbiology/Virology
	LASV inhibitor 3.3 是一种针对溶酶体相关膜蛋白 1 (LAMP1) 的拉沙热病毒 (LASV) 抑制剂，LAMP1 是一种在感染期间与 LASV 糖蛋白 (GP) 结合的宿主因子。
T76975	Tomaralimab OPN-305	TLR	Immunology/Inflammation
	Tomaralimab (OPN-305) 是一种人源化的靶向 TLR2 的 IgG4 单克隆抗体。Tomaralimab 可用于研究骨髓增生异常综合征 (MDS) 。
T25549	JCP174 JCP 174,JCP-174	Serine Protease	Proteases/Proteasome
	JCP174是一种去棕榈酰化酶抑制剂，可通过靶向 TgPPT1增强弓形虫的宿主细胞侵袭。
T13600	CDD3505 4-nitro-1-trityl-1H-imidazole	P450	Metabolism
	CDD3505 (4-nitro-1-trityl-1H-imidazole) 能够诱导肝CYP3A 的活动，增强高密度脂蛋白胆固醇的水平。
T3995	Amcasertib 安卡舍替,BBI503	Stemness kinase	Stem Cells
	Amcasertib (BBI503) 是一种cancer stemness kinase 抑制剂，抑制Nanog 和其他癌症干细胞通路，具有潜在的抗癌活性。
T2588	Ivacaftor Ivacaftor (VX-770),VX-770,依伐卡托	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	Ivacaftor (VX-770) 是一种 CFTR 增强剂，靶向G551D-CFTR 和F508del-CFTR 的EC50分别为100 和 25 nM。
T13601	CDD3506 1-TRITYL-1H-IMIDAZOL-4-AMINE	P450	Metabolism
	CDD3506 (1-TRITYL-1H-IMIDAZOL-4-AMINE) 能够诱导肝CYP3A 的活动，增强高密度脂蛋白胆固醇的水平。

化合物

Neuromuscular-targeting compound 1

Cat.No: T13491

Target: Others

Cancer-Targeting Compound 1

Cat.No: T13572

Target: Others

Itch-Targeting Compound 1

Cat.No: T10071

Target: Others

Arrhythmic-Targeting Compound 1

Cat.No: T13900

Target: Others

Arrhythmias-Targeting Compound 1

Cat.No: T13573

Target: Others

Neurodegenerative Disorder-Targeting Compound 1

Cat.No: T13486

Target: Others

Neuromuscular Disorder-Targeting Compound 1

Cat.No: T10059

Target: Others

Urinary Incontinence-Targeting Compound 1

Cat.No: T19417

Target: Others

TPP-1 hydrochloride

Cat.No: T83724

Synonym: Targeting PD-L1 Peptide

Soluble Epoxide Hydrolase PROTAC 1a

Cat.No: T83857

Synonym: sEH Proteolysis-targeting Chimera 1a,Soluble Epoxide Hydrolase Proteolysis-targeting Chimera 1a,sEH PROTAC 1a

(Rac)-Neurodegenerative Disorder-Targeting Compound 1

Cat.No: T83527

Targeting the bacterial sliding clamp peptide 46

Cat.No: T76218

Cat.No: T60015

Synonym: Carbonic acid

Target: AUTACs

Cat.No: T11249L

Synonym: Exatecan derivative for ADC,OQM5SD32BQ,UNII-OQM5SD32BQ

Target: Topoisomerase

Cat.No: T22282

Synonym: Brr2 Inhibitor 9,Brr2 Inhibitor C9

Target: Others

5(6)-Carboxyfluorescein

Cat.No: T18893

Synonym: 5(6)-羧基荧光素,5-(and-6)-Carboxyfluorescein mixed isomers,5(6)-FAM

Target: Others

Cat.No: T6804

Synonym: Chaetomin,NSC289491,BRN0077366

Target: Apoptosis, HSP, HIF

tri-GalNAc-COOH

Cat.No: T39370

Target: LYTACs

ALK kinase inhibitor-1

Cat.No: T6409

Synonym: SAR348830

Target: Others

Cat.No: T5374

Target: E1/E2/E3 Enzyme, NEDD8

Dopamine D2 receptor agonist-2

Cat.No: T60075

Synonym: Dopamine D2 Receptor

Target: Dopamine Receptor

Cat.No: T10531

Synonym: JNJ-26483327

Target: EGFR, VEGFR, FLT, Src

Cat.No: T1832

Target: Antibacterial, Antibiotic

Ehp-inhibitor-2

Cat.No: T5452

Target: Ephrin Receptor

Eph inhibitor 2

Cat.No: T5451

Synonym: Ehp-inhibitor-1

Target: Ephrin Receptor

Cat.No: T9584

Target: Others, Histone Methyltransferase

5-Methoxyuridine

Cat.No: TNU0123

Synonym: Mo5U

Target: Apoptosis

α-Conotoxin PIA acetate

Cat.No: TP2065L

Target: AChR

Theodrenaline hydrochloride

Cat.No: T13142L

Synonym: Theodrenaline hydrochloride(13460-98-5 Free base)

Target: SARS-CoV

Cat.No: T8955

Target: Others

NSC 146109 hydrochloride

Cat.No: T12257

Target: Apoptosis, Others

Cephalexin monohydrate

Cat.No: T20022

Synonym: Cephalexin hydrate,Cephacillin hydrate,Cefalexin hydrate

Target: Antibiotic

Cat.No: T39024

Target: Cannabinoid Receptor

Cat.No: T23777

Synonym: BCI137

Target: Others

Pomalidomide-PEG2-OH

Cat.No: T9383

Synonym: 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-(2-hydroxyethoxy)ethyl]amino]-

Target: PROTACs

Pomalidomide-PEG3-OH

Cat.No: T9384

Synonym: 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]amino]-

Target: PROTACs

Cat.No: T21807

Synonym: Triptycene-1,4-quinone

Target: Others

2'-Deoxy-2'-fluorouridine

Cat.No: T38239

Cat.No: TNU0022

Synonym: 6-Azuridine

Target: Apoptosis

Cat.No: T9927

Target: EGFR

Cat.No: T41277

Target: Others

Cat.No: T4459

Target: DNA Alkylator/Crosslinker

Cat.No: T19826

Synonym: LY307640

Target: Potassium Channel, STAT

LASV inhibitor 3.3

Cat.No: T9957

Target: Virus Protease

Cat.No: T76975

Synonym: OPN-305

Target: TLR

Cat.No: T25549

Synonym: JCP 174,JCP-174

Target: Serine Protease

Cat.No: T13600

Synonym: 4-nitro-1-trityl-1H-imidazole

Target: P450

Cat.No: T3995

Synonym: 安卡舍替,BBI503

Target: Stemness kinase

Cat.No: T2588

Synonym: Ivacaftor (VX-770),VX-770,依伐卡托

Target: CFTR, Autophagy

Cat.No: T13601

Synonym: 1-TRITYL-1H-IMIDAZOL-4-AMINE

Target: P450

Cat. No.	Product Name	Target	Signaling Pathways
T6212	Combretastatin A4 CA4,康普瑞汀,Z)-3,4,5,4',-四甲氧基-3'-羟基二苯乙烯,CRC 87-09	Microtubule Associated	Cytoskeletal Signaling
	Combretastatin A4 (CA4) 是一种微管靶向剂，可结合 β-tubulin，Kd 值为 0.4 μM。
T5225	Hypotaurine 2-Aminoethanesulfinic acid,亚牛磺酸,2-Aminoethylsulfinic acid	Chloride channel; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism
	Hypotaurine (2-Aminoethanesulfinic acid) 是星形胶质细胞中半胱氨酸生物合成的牛磺酸中间体，是甘氨酸受体 (glycine receptor) 的内源性抑制性氨基酸。Hypotaurine 也是抗氧化剂。
T5770	Alisol B	RANKL/RANK	NF-κB
	Alisol B 是一种具有用于骨科疾病研究潜力的化合物，通过分化破骨细胞发挥其功能。
TN1068	Tricin	Others; CDK	Cell Cycle/Checkpoint; Others
	Tricin 是米糠中大量存在的一种天然类黄酮。它通过抑制 CDK9 来抑制HCMV 的复制。它通过上调 FAK 靶向 microRNA-7 的表达来抑制 C6 胶质瘤细胞的增殖和侵袭。
TNU0052	Nebularine 9-(beta-D-Ribofuranosyl)-9H-purine	Apoptosis	Apoptosis
	Nebularine (9-(beta-D-Ribofuranosyl)-9H-purine)，是一种嘌呤核苷类似物，具有广谱的抗肿瘤活性，针对惰性淋巴恶性肿瘤并诱导凋亡。Nebularine的抗癌机制依赖于抑制DNA合成。
T9715	Aplidine	SARS-CoV; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Aplidine 是有效的eEF1A2(KD=80 nM) 靶向的抗癌药物。Aplidine 具有抗病毒活性，抑制SARS-CoV-2的 IC90为 0.88 nM。Aplidine 在多发性骨髓瘤，晚期癌症及 COVID-19 领域有研究的价值。
T3777	Praeruptorin A (+)-Praeruptorin A,白花前胡甲素	CaMK; NF-κB	Neuroscience; NF-κB
	Praeruptorin A ((+)-Praeruptorin A) 是一种白花前胡的主要生物活性成分。它能够抑制 NF-κB 活化，发挥抗炎作用。
T6272	Fosbretabulin Disodium Combretastatin A4 Phosphate,CA 4DP,CA 4P,福他布林,Combretastatin A4 disodium phosphate,Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Fosbretabulin Disodium (CA 4P) 是一种微管蛋白去稳定剂，是 Combretastatin A4 前药，可选择性靶向内皮细胞，诱导新生肿瘤新血管消退，减少肿瘤血流量并引起中央肿瘤坏死。
T36857	Estrone sulfate sodium 雌酮3-硫酸钠,Estrone 3-sulfate (sodium salt),17β-Estrone 3-sulfate	Endogenous Metabolite	Metabolism
	Estrone sulfate sodium (17β-Estrone 3-sulfate) 是一种主要的循环血浆雌激素，无生物活性，通过类固醇硫酸酯酶(STS) 转化为生物活性雌激素雌酮。
T3752	4-Hydroxybenzyl alcohol 4-Methylolphenol,P-Methylolphenol,对羟基苯甲醇	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	4-Hydroxybenzyl alcohol (P-Methylolphenol) 是广泛分布于各种植物中的一种酚类天然产物，具有抗炎、抗氧化和抗伤害感受活性。它抑制肿瘤血管生成和生长，有神经保护作用。
TN1308	6-Hydroxyflavanone	Others; Lipoxygenase; COX; GABA Receptor	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; Others
	6-Hydroxyflavanone 是从菖蒲叶中提取分离，通过靶向环氧合酶-2（COX-2），5-脂氧合酶（5-LOX）以及阿片类药物和 GABA-A 受体从而具有抗炎和抗神经性疼痛活性。6-Hydroxyflavanone 在链脲佐菌素诱导的糖尿病神经病变模型中具有抗伤害感受特性。
T6S1740	Nardosinone 苷松新酮,甘松新酮	Others	Others
	Nardosinone 是一个 dbcAMP 和 staurosporine 的神经生成作用增强剂，分离自Nardostachys chinensis 中。Nardosinone 可能成为一种有用的药理学工具，不仅可用于研究神经生长因子 (NGF) 的作用机理，而且可用于研究神经毒性物质的作用机理。
TJS1779	Protosappanin A 原苏木素A,PTA	NADPH-oxidase; IL Receptor; IκB/IKK; TNF; NF-κB; TLR; ROS; COX; HIV Protease; JAK; NO Synthase; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells
	Protosappanin A (PTA) 是从苏木中分离得到的免疫抑制成分和主要联苯化合物，通过下调 JAK2和 STAT3的磷酸化，抑制 JAK2/STAT3依赖的炎症通路。
T4S1419	(±)-Praeruptorin A Praeruptorin A,(±)-白花前胡甲素,白花前胡甲素,(-)-Praeruptorin A	p38 MAPK; Calcium Channel; Akt	Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
	(±)-Praeruptorin A 是来自白花前胡的干燥根中的一种主要成分，用于研究伴有厚痰和呼吸困难的咳嗽，非天生性咳嗽和上呼吸道感染。它是顺式-内酯 (CKL) 的二酯化产物，可作为 Ca2+-反流阻滞剂，用于高血压的研究。
T11215	Episilvestrol	Others	Others
	Episilvestrol is a specific eIF4A-targeting translation inhibitor, with antitumor activity. Episilvestrol is a derivative of silvestrol, isolated from the fruits and twigs of Aglaia silvestris.
TL0017	Aristolactam AIIIa	MAPK; CDK	Cell Cycle/Checkpoint; MAPK
	Aristolactam AIIIa is a new type of Plk1 inhibitors, targeting the Polo Box domain (PBD), it has anti-tumor activity. Aristolactam IIIa shows inhibition of platelet aggregation induced by collagen or arachidonic acid.
T10072	2-Hydroxy Ibuprofen 2-羟基布洛芬,(±)-2-Hydroxy Ibuprofen	Others	Others
	2-Hydroxy Ibuprofen is a metabolite of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1/COX-2 (IC50s: 13 μM/370 μM).
TN6651	Picrasidine Q
	Picrasidine Q has the capacity of anti-cell transformation and anti-cancer, it might be a chemopreventive and chemotherapeutic agent by direct targeting FGFR2 and inhibiting cell proliferation of ESCC cells.
TN3809	Dehydrojuncusol	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Dehydrojuncusol, a new inhibitor of hepatitis C virus RNA replication, it inhibits infection of different HCV genotypes by targeting the NS5A protein and is active against resistant HCV variants frequently found in patients with treatment failure.
T16719	Radicicol 根赤壳菌素,Monorden	HSP	Cytoskeletal Signaling; Metabolism
	Radicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol is an inhibitor of Hsp90 (IC50: 1 μM). Radicicol binds to the ATPase domain of Hsp90 and prevents maturation of Hsp90 clients,
T83367	3,5-Diprenyl-4-hydroxyacetophenone
	3,5-Diprenyl-4-hydroxyacetophenone（化合物8）是从桔梗地上部分分离出的化合物，具有钙调素靶向性。
T83518	(S)-O-Methylencecalinol
	(S)-O-Methylencecalinol (compound 10)，一种从Ageratina grandfolia地上部分分离得到的化合物，目标是钙调素。
T15467	Helenalin	Others	Others
	Helenalin is a selective inhibitor of transcription factor NF-κB by direct targeting of p65. It is an anti-inflammatory sesquiterpene lactone compound with alkylating activity. Through its ability to target the cysteine sulfhydryl groups in the p65 subunit of NF-κB, helenalin effectively inhibits its DNA binding.
TN1985	Neoprzewaquinone A	ROCK; Pim; STAT	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Stem Cells
	Neoprzewaquinone A (NEO) 是 S. miltiorrhiza 的活性成分，通过靶向 PIM1 阻断 ROCK2/STAT3 通路来抑制乳腺癌细胞迁移并促进平滑肌松弛。
TN4840	Psoromic acid	Others	Others
	Psoromic acid is a selective and covalent rab-prenylation inhibitor targeting autoinhibited RabGGTase, it shows antibacterial activities against Streptococcus gordonii and Porphyromonas gingivalis, and it is an effective and safe natural drug plausible fo
T79951	Piperkadsin A	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Piperkadsin A作为一种ROS抑制剂，能够有效地抑制PMA诱导的人多形核中性粒细胞中ROS的生成，其IC50值为4.3 μM。
TN5880	Mesuol
	Mesuol has antioxidant activity, it shows very high scavenging activity against DPPH radical; it also has immunomodulatory activity, can potentiate percentage neutrophil adhesion in neutrophil adhesion test in rats and phagocytosis in carbon clearance assay. Mesuol can suppress HIV-1 replication in Jurkat T cells, it inhibits TNFα-induced HIV-1-LTR transcriptional activity by targeting the nuclear factor-κB (NF-κB) pathway.
TN4605	Myriceric acid B	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41 and can serve as a lead compound for developing novel anti-HIV-1 drug. Myriceric acid B scavenges DPPH free radicals with IC50 value of 21.8 uM, it inhibits aromatase activity with IC50 val
TL0014	Pinusolide	ERK; p38 MAPK; Calcium Channel; Lipoxygenase; PAFR; Caspase; JNK; AMPK	Apoptosis; Chromatin/Epigenetic; GPCR/G Protein; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to treat neurodegenerative diseases. Pinusolide attenuates blockade of insulin signaling by enhancing IRS-1 tyrosine phosphorylation by the activating the AMPK pathway, indicates the targeting of AMPK represents a new therapeutic strategy for hyperglycemia-induced insulin resistance and type 2 diabetes.
TN4213	Hirsutenone	ERK; EGFR; IL Receptor; NF-κB; Akt; PI3K; Antifection; mTOR; p53; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid peroxidation.Hirsutenone exhibits anti-cancer, and anti-filarial effects, it may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-...
TMA0984	Cerevisterol	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Cerevisterol 是一种细胞毒性类固醇，提取于Agaricus blazei 子实体，对 DNA 聚合酶 α 的活性具有抑制作用。
TN4263	Isoangustone A	MMP; GSK-3; NF-κB; ROS; Akt; PI3K; CDK; JNK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Isoangustone A dampens mesangial sclerosis associated with inflammation in response to high glucose through hindering TGF-β and NF-ÎºB signaling. Isoangustone A also shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals.
T73730	Distamycin A
	Distamycin A (NSC-82150)为一种寡肽抗生素及小沟结合剂，其结合B型DNA，并倾向于A/T富集区。Distamycin A能调节烯二炔诱导DNA切割位点并促进细胞凋亡。
T78465	H-γ-Glu-Gln-OH γ-Glutamylglutamine,γ-Glu-Gln
	H-γ-Glu-Gln-OH 是一种水溶性肽类化合物，用于药物结合。该载体特征为高溶解度、药物负载效能、优良生物相容性、低毒性，并能增强抗癌药物对肿瘤的靶向作用及疗效。
T73813	Haemanthamine hydrochloride
	Haemanthamine hydrochloride 是从Amaryllidaceae 植物中分离出来的一种蛇毒碱样生物碱，具有强大的抗癌活性。Haemanthamine hydrochloride 靶向核糖体以在翻译的延长阶段抑制蛋白质的生物合成。Haemanthamine hydrochloride 具有促凋亡，抗氧化剂，抗病毒，抗疟疾和抗惊厥活性。
T73066	Thielavin B
	Thielavin B为Thielavin terricola产生的前列腺素生物合成抑制剂。该化合物能有效抑制内过氧物酶介导的前列腺素E2合成，并在静脉注射后显著降低大鼠因角叉菜胶引发的水肿。
TN1953	Morusinol 桑根皮醇,桑树醇	ERK; MEK; Autophagy; Ras	Autophagy; GPCR/G Protein; MAPK
	Morusinol 是从桑树根皮中提取出的类黄酮。 Morusinol 具有抗血小板和抗癌活性，在体内抑制动脉血栓形成，通过诱导自噬、G2/M 细胞周期阻滞、抑制细胞侵袭和迁移以及靶向 Ras/MEK/ERK 通路发挥抗肿瘤活性。
T72208	1-Dehydro-[10]-gingerdione
	1-Dehydro-[10]-gingerdione 通过靶向IKKβ的激活环直接抑制 IKKβ 活性，从而破坏用激动剂刺激的巨噬细胞中 IKKβ 催化的 IκBα 磷酸化。1-Dehydro-[10]-gingerdione 抑制 LPS 诱导的NF-κB 转录活性。1-Dehydro-[10]-gingerdione 具有用于NF-κB 相关炎症和自身免疫性疾病研究的潜力。
T79975	Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside	HBV	Microbiology/Virology
	Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside（化合物1）是一种具有抗HBV活性的木脂素类化合物。该化合物对HBV表面抗原（HBsAg）的IC50为0.58 mM，而对HBV e抗原（HBeAg）的IC50 > 2.4 mM。其可从八角茴香中提取分离。
TN4838	Pseurotin A	Antifection	Microbiology/Virology
	Pseurotin A has immunosuppressive activity, it inhibits immunoglobulin E(IgE) production in vitro.It shows a moderate effect against the phytopathogenic bacteria Erwinia carotovora and Pseudomonas syringae, with IC50 values of 220 and 112 microg ml(-1), r
T72803	Norartocarpetin
	Norartocarpetin 是一种酪氨酸酶抑制剂。Norartocarpetin 具有较强的酪氨酸酶抑制活性，其抑制活性 IC50值为 0.47 μM。Norartocarpetin 作为一种抗褐变剂可用于食品体系的研究。Norartocarpetin 对肺癌细胞 (NCI-H460) 也具有显著的抗癌活性，其 IC50值为 22 μM。Norartocarpetin 的抗增殖作用是通过靶向 Ras/Raf/MAPK 信号通路、线粒体介导的细胞凋亡、S 期细胞周期阻滞和抑制细胞迁移和侵袭实现的。
TN3364	Agrimonolide	Apoptosis; Dehydrogenase; p38 MAPK; ROS; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; MAPK; Metabolism; Stem Cells
	Agrimonolide 是一种来自异香豆素的化合物，主要存在于草药Agrimonia pilosa Ledeb 中，具有显著的生物活性。Agrimonolide 通过抑制脂多糖（LPS）诱导的JAK-STATs 和p38 MAPKs 信号通路的激活而发挥抗炎作用。Agrimonolide 及其衍生物去甲阿戈莫内德已显示出能够有效提高肝细胞中胰岛素介导的糖原水平，可能在调节胰岛素抵抗的HepG2细胞中发挥关键作用。Agrimonolide 通过靶向卵巢癌细胞中的SCD1，对癌症的进展和诱导细胞死亡和凋亡表现出抑制作用。特别是，Agrimonolide 对A2780和SKOV-3细胞的增殖、迁移和侵袭表现出剂量依赖性的抑制，同时促进细胞凋亡。该化合物还被发现能诱导铁介导的细胞死亡，同时增加活性氧（ROS）和总铁的水平。Agrimonolide 很容易穿过血脑屏障，表明其在神经系统疾病的治疗应用方面具有潜力。

天然产物

Combretastatin A4

Cat.No: T6212

Synonym: CA4,康普瑞汀,Z)-3,4,5,4',-四甲氧基-3'-羟基二苯乙烯,CRC 87-09

Target: Microtubule Associated

Cat.No: T5225

Synonym: 2-Aminoethanesulfinic acid,亚牛磺酸,2-Aminoethylsulfinic acid

Target: Chloride channel, Endogenous Metabolite

Cat.No: T5770

Target: RANKL/RANK

Cat.No: TN1068

Target: Others, CDK

Cat.No: TNU0052

Synonym: 9-(beta-D-Ribofuranosyl)-9H-purine

Target: Apoptosis

Cat.No: T9715

Target: SARS-CoV, DNA/RNA Synthesis

Cat.No: T3777

Synonym: (+)-Praeruptorin A,白花前胡甲素

Target: CaMK, NF-κB

Fosbretabulin Disodium

Cat.No: T6272

Synonym: Combretastatin A4 Phosphate,CA 4DP,CA 4P,福他布林,Combretastatin A4 disodium phosphate,Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium

Target: Apoptosis, Microtubule Associated

Estrone sulfate sodium

Cat.No: T36857

Synonym: 雌酮3-硫酸钠,Estrone 3-sulfate (sodium salt),17β-Estrone 3-sulfate

Target: Endogenous Metabolite

4-Hydroxybenzyl alcohol

Cat.No: T3752

Synonym: 4-Methylolphenol,P-Methylolphenol,对羟基苯甲醇

Target: Apoptosis, Endogenous Metabolite

6-Hydroxyflavanone

Cat.No: TN1308

Target: Others, Lipoxygenase, COX, GABA Receptor

Cat.No: T6S1740

Synonym: 苷松新酮,甘松新酮

Target: Others

Protosappanin A

Cat.No: TJS1779

Synonym: 原苏木素A,PTA

Target: NADPH-oxidase, IL Receptor, IκB/IKK, TNF, NF-κB, TLR, ROS, COX, HIV Protease, JAK, NO Synthase, STAT

(±)-Praeruptorin A

Cat.No: T4S1419

Synonym: Praeruptorin A,(±)-白花前胡甲素,白花前胡甲素,(-)-Praeruptorin A

Target: p38 MAPK, Calcium Channel, Akt

Cat.No: T11215

Target: Others

Aristolactam AIIIa

Cat.No: TL0017

Target: MAPK, CDK

2-Hydroxy Ibuprofen

Cat.No: T10072

Synonym: 2-羟基布洛芬,(±)-2-Hydroxy Ibuprofen

Target: Others

Cat.No: TN6651

Dehydrojuncusol

Cat.No: TN3809

Target: HCV Protease

Cat.No: T16719

Synonym: 根赤壳菌素,Monorden

Target: HSP

3,5-Diprenyl-4-hydroxyacetophenone

Cat.No: T83367

(S)-O-Methylencecalinol

Cat.No: T83518

Cat.No: T15467

Target: Others

Neoprzewaquinone A

Cat.No: TN1985

Target: ROCK, Pim, STAT

Cat.No: TN4840

Target: Others

Cat.No: T79951

Target: Reactive Oxygen Species

Cat.No: TN5880

Myriceric acid B

Cat.No: TN4605

Target: HIV Protease

Cat.No: TL0014

Target: ERK, p38 MAPK, Calcium Channel, Lipoxygenase, PAFR, Caspase, JNK, AMPK

Cat.No: TN4213

Target: ERK, EGFR, IL Receptor, NF-κB, Akt, PI3K, Antifection, mTOR, p53, Autophagy

Cat.No: TMA0984

Target: DNA/RNA Synthesis

Cat.No: TN4263

Target: MMP, GSK-3, NF-κB, ROS, Akt, PI3K, CDK, JNK

Cat.No: T73730

H-γ-Glu-Gln-OH

Cat.No: T78465

Synonym: γ-Glutamylglutamine,γ-Glu-Gln

Haemanthamine hydrochloride

Cat.No: T73813

Cat.No: T73066

Cat.No: TN1953

Synonym: 桑根皮醇,桑树醇

Target: ERK, MEK, Autophagy, Ras

1-Dehydro-[10]-gingerdione

Cat.No: T72208

Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside

Cat.No: T79975

Target: HBV

Cat.No: TN4838

Target: Antifection

Norartocarpetin

Cat.No: T72803

Cat.No: TN3364

Target: Apoptosis, Dehydrogenase, p38 MAPK, ROS, JAK

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