95
63
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0220 |
Foscarnet sodium
Phosphonoformate,膦甲酸钠 |
Virus Protease; Reverse Transcriptase; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Foscarnet sodium (Phosphonoformate) 是一种病毒 DNA 聚合酶活性抑制剂,可逆地抑制病毒复制。它是一种用于治疗巨细胞病毒性视网膜炎的抗病毒剂。 | |||
T7943 |
Fluphenazine decanoate
|
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Fluphenazine decanoate 是一种高度连续的多巴胺 D2受体阻滞剂,是一种长效吩噻嗪抗精神病药,用于精神分裂症的研究。 | |||
T21422 |
Methylnaltrexone bromide
Relistor,MOA-728,MOA 728,Methylnaltrexone,溴化甲基纳曲酮,MOA728 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Methylnaltrexone bromide (MOA-728) 是纳曲酮的四元衍生物,是可口服的外周作用 μ 阿片拮抗剂。它穿越血脑屏障的能力有限,可在胃肠道组织中发挥作用。 | |||
T11174 |
(R)-Elagolix
恶拉戈利,NBI-56418 |
GNRH Receptor | GPCR/G Protein |
(R)-Elagolix (NBI-56418) 是口服具有活性的、选择性高的非肽类促性腺激素释放激素受体短期有效拮抗剂 (KD = 54 pM)。 | |||
T8400 |
Pamidronic acid
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Pamidronic acid 可用于各种骨吸收类疾病的研究。 | |||
T20802 |
Flumethasone pivalate
Locacorten,NSC-107680,特戊酸氟米松,Lorinden,NSC 107680,NSC107680,Locorten |
Others | Others |
Flumethasone pivalate (Locorten) 具有止痒、抗炎和血管收缩的特性,可用于肾上腺皮质抑制、皮肤萎缩、血浆转皮质素结合和毛细血管扩张的研究。 | |||
T11079 |
NMI 8739
n-docosahexaenoyl dopamine,Dha-DA conjugate |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
NMI 8739 (n-docosahexaenoyl dopamine) 是 D2 自身受体的激动剂。 NMI 8739 减少 NO 的产生并引起 CCL-20、MCP-1 和 IL-6 释放的浓度依赖性抑制。 | |||
T4981 |
Anisotropine Methylbromide
|
Prostaglandin Receptor; AChR | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Anisotropine Methylbromide 是一种抗胆碱能药物,已用于缓解胃肠道痉挛和抑制胃酸分泌。 | |||
T2498 |
Adjudin
AF-2364 |
Chloride channel; Mitochondrial Metabolism | Membrane transporter/Ion channel; Metabolism |
Adjudin (AF-2364) 是广泛研究的男性避孕试剂,可通过抑制 NF-κB 通路来减弱小胶质细胞的活化。 | |||
T60098 |
MSC2504877
3-(4-(2-Hydroxypropan-2-yl)phenyl)-6-methylpyrrolo[1,2-a]pyrazin-1(2H)-one |
Others | Others |
MSC2504877 是一种tankyrase 抑制剂,可增强临床CDK4/6 抑制剂的作用。 MSC2504877 抑制由 palbociclib 引起的 Cyclin D2 和 Cyclin E2 的上调,并增强对 phospho-Rb 的抑制。 | |||
T11669 |
IR415
|
HBV | Microbiology/Virology |
IR415 选择性地与 HBx 相互作用 (Kd=2 nM) 并阻断 HBV 介导的 RNAi 抑制,逆转 HBx 蛋白对 Dicer 核糖核酸内切酶活性的抑制作用。IR415 具有抗 HBV 的活性。 | |||
T9953 |
BT173
|
Others | Others |
BT173 是一种新型的同源域相互作用蛋白激酶 2 (HIPK2) 抑制剂,通过抑制 TGF-β1/Smad3 通路减轻肾纤维化。 | |||
T13974 |
ZL0580
|
Epigenetic Reader Domain; HIV Protease | Chromatin/Epigenetic; Microbiology/Virology; Proteases/Proteasome |
ZL0580 通过抑制 Tat 反式激活和转录延伸以及通过在 HIV 启动子处诱导抑制性染色质结构来诱导 HIV 抑制。 | |||
T13360 |
XRK3F2
|
Autophagy | Autophagy |
XRK3F2 是 p62-ZZ 结构域的抑制剂,在体外减弱 MM 诱导的 Runx2 抑制,在体内肿瘤存在的情况下诱导新骨形成和重塑。 | |||
T2589 |
Dolasetron Mesylate hydrate
Dalasetron Mesylate Hydrate,多拉司琼甲磺酸盐一水合物 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Dolasetron Mesylate hydrate (Dalasetron Mesylate Hydrate) 是一种选择性血清素受体拮抗剂,可竞争性阻断血清素对 5HT3 受体的作用,从而抑制化疗和放疗引起的恶心和呕吐。 | |||
T11820 |
LAT1-IN-1
2-氨基-2-去甲菠烷羧酸,BCH |
Apoptosis; Others | Apoptosis; Others |
LAT1-IN-1 (BCH) 是 L 型氨基酸转运蛋白 1 的选择性竞争性抑制剂,显着抑制细胞对氨基酸的摄取和 mTOR 磷酸化,从而诱导抑制癌症生长和细胞凋亡。 | |||
T27392 |
FT001
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
FT001是一种有效的、选择性的和具有口服活性的 BET Bromodomain 抑制剂,具有抗肿瘤活性。FT001抑制 MYC 的表达,IC50为0.46 μM。FT001对 MV-4-11具有有效的抗增殖作用,并在体外和体内显著抑制 MYC mRNA 水平。 | |||
T1167 |
Cyproterone acetate
Androcur,醋酸环丙氯地孕酮,Cyproterone 17-O-acetate,醋酸环丙孕酮 |
Androgen Receptor | Endocrinology/Hormones |
Cyproterone acetate (Cyproterone 17-O-acetate) 是能够抗雄激素(IC50=7.1 nM) 和孕激素合成的类固醇。它与 progesteron 和糖皮质激素受体有亲和力。 | |||
T68405 |
KW-2450 free base
|
IGF-1R | Tyrosine Kinase/Adaptors |
KW-2450 free base 是一种 IGF-1R/IR和酪氨酸激酶多重抑制剂 具有抗肿瘤活性。KW-2450 free base 在小鼠 HT-29/GFP 结肠癌异种移植模型中显示出适度的生长抑制活性并抑制 IGF-1 诱导的信号转导。 | |||
T20660 |
Revaprazan
SB-641257,SB 641257,SB641257 |
||
Revaprazan is a novel, selective potassium-competitive acid blocker, to be specific, it reversibly inhibits gastric H(+)/K(+)-ATPase and shows effective acid suppression comparable to PPIs. | |||
T19854 |
Evoxine
|
||
Evoxine is a selective inhibitor of CO2-induced immune suppression. It inhibits hypercapnic suppression of interleukin-6 and the chemokine CCL2 expression in human THP-1 macrophages. | |||
T25576 |
KF 392
KF392,KF-392 |
||
KF 392 is antiulcer. It was found that KF-392 given orally to rats at 1.0 to 5.0 mg/kg had a marked suppression on the developments of Shay ulcer as well as the aspirin-, stress-, and reserpine-induced gastric lesions. | |||
T34632 |
SH-5
SH5 PIA5. LchiroInositol 1deoxy6Omethyl 5(2R)2methoxy3(octadecyloxy)propyl hydrogen phosphate. Akt inhibitor II |
||
SH-5 是一种AKT抑制剂,通过抑制IκBα激酶激活调节的抗凋亡、增殖和转移基因产物,增强细胞凋亡并抑制侵袭。 | |||
T61623 |
Ecabet
|
||
Ecabet sodium (TA-2711) is a chemical compound utilized for the clinical treatment of gastrointestinal disease through the suppression of reactive oxygen species (ROS) generation and enhancement of Helicobacter pylori eradication [1]. Moreover, Ecabet sodium effectively attenuates apoptosis [2]. | |||
T21131 |
NASTRp
Naphthol AS-TR phosphate |
||
NASTRp, an inhibitor of CREB-CBP complex, possesses anti-cancer effects along with cell cycle regulation, autophagy suppression, and endoplasmic reticulum stress. | |||
T61118 | CD73-IN-12 | ||
CD73-IN-12 is a highly effective CD73 inhibitor that displays strong potential in tumor suppression. CD73, an enzyme intricately linked to tumor development, angiogenesis, and metastasis, is significantly inhibited by CD73-IN-12. This compound holds promise in the formulation of therapeutic medications targeting tumor-related diseases[1]. | |||
T41081 |
Pyrazosulfuron-ethyl
|
||
Pyrazosulfuron-ethyl, a sulphonylurea herbicide belonging to the acetolactate synthase inhibiting category, has gained extensive application in the suppression of weed proliferation within commercial cereal, soybean, and vegetable fields. | |||
T24787 |
SGE-201
|
||
SGE-201 is an allosteric modulator of N-methyl-D-aspartate receptors. SGE-201 also unmasked differences among the blockers in neuronal networks - measured either by suppression of activity in multi-electrode arrays or by neuroprotection against a mild exc | |||
T26577 |
AGN-201904Z
AGN-201904-Z,AGN-201904 |
||
AGN-201904Z is a slowly absorbed, acid-stable pro-proton pump inhibitor (pro-PPI) rapidly converted to omeprazole in the systemic circulation giving a prolonged residence time. AGN 201904-Z produced a significantly greater, and nocturnal acid suppression | |||
T13574 |
Besifovir Dipivoxil maleate
LB80380 maleate |
Others | Others |
Besifovir Dipivoxil (LB80380) maleate is an oral prodrug of LB80317. Besifovir Dipivoxil maleate is effective in hepatitis B virus (HBV) DNA suppression for both treatment-naive and lamivudine-resistant chronic hepatitis B (CHB) patients. | |||
T69990 |
Ruboxistaurin mesylate monohydrate
|
||
Ruboxistaurin mesylate monohydrate is a PKC beta inhibitor potentially for the treatment of diabetic nephropathy and diabetic macular edema. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt. | |||
T80909 | Tyrosinase-IN-19 | Tyrosinase | Proteases/Proteasome |
Tyrosinase-IN-19 是竞争性酪氨酸酶抑制剂,对ROS、ABTS+ 及DPPH 自由基展现显著的抗氧化活性。该化合物通过剂量依赖性方式有效抑制酪氨酸酶表达。 | |||
T68528 |
M-COPA
|
||
M-COPA is a golgi disruptor which inhibits cell surface expression of MET protein and the ADP-ribosylation factor 1 (Arf1) activation. M-COPA also inhibits angiogenesis through suppression of both VEGFR1/2 and nuclear factor-kappaB (NF-kappaB) signaling pathways. | |||
T3689L |
Ruboxistaurin mesylate
LY-333531,LY333531,LY 333531,LY-333531 Mesylate |
||
Ruboxistaurin is a PKC beta inhibitor. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/ | |||
T61328 |
CO delivery molecule 1
|
||
CO delivery molecule 1 (compound 4) exhibits subcellular localization in the endoplasmic reticulum, mitochondria, and lysosomes. Such localization leads to the manifestation of CO-induced toxicity effects. Notably, the anti-inflammatory properties of CO delivery molecule 1, quantified through TNF-α suppression, are evident at nanomolar concentrations even without CO release. Furthermore, visible-light-induced CO release further enhances its anti-inflammatory effects [1]. | |||
T61789 | IDO1-IN-14 | ||
IDO1-IN-14 (compound 4a) is a highly effective inhibitor of the IDO1 enzyme, exhibiting an IC50 value of 396.9 nM. Additionally, IDO1-IN-14 demonstrates excellent suppression of cellular IDO1 activity, as observed in HeLa cells with an EC50 value of 3393 nM [1]. | |||
T15831 |
M-525
|
Others | Others |
M-525 binds to menin (IC50: 3 nM) and achieves low nanomolar potencies in cell growth inhibition and in the suppression of MLL regulated gene expression in MLL leukemia cells. M-525 is a first-in-class, highly potent, irreversible, and covalent menin-MLL | |||
T70058 |
PQR514
|
||
PQR514 is a potent pan-PI3K inhibitor (Ki 110alpha =2.2 nM). PQR514 is a follow-up compound for the phase-II clinical compound PQR309. PQR514 has an improved potency both in vitro and in cellular assays with respect to its predecessor compounds. It shows superiority in the suppression of cancer cell proliferation and demonstrates significant antitumor activity in an OVCAR-3 xenograft model at concentrations approximately eight times lower than PQR309 | |||
T71520 |
LEQ-506
|
||
LEQ506, also known as NPV-LEQ506, is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Smoothened antagonist LEQ506 selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway, thereby inhibiting tumor cell growth. | |||
T79096 | IPG7236 | CCR | Immunology/Inflammation; Microbiology/Virology |
IPG7236为选择性CCR8拮抗剂,于人乳腺癌小鼠异种移植模型中展现显著肿瘤抑制效果,适用于癌症研究。 | |||
T61627 | iMDK quarterhydrate | ||
iMDK quarterhydrate, a potent PI3K inhibitor, is effective in inhibiting the growth factor MDK (also known as midkine or MK) while demonstrating suppression of non-small cell lung cancer (NSCLC). In combination with a MEK inhibitor, iMDK quarterhydrate demonstrates cooperative inhibition of NSCLC without causing harm to normal cells and mice [1]. | |||
T40211 |
eIF4E-IN-1
eIF4E-IN-1 |
||
eIF4E-IN-1 (WO2021003194A1, compound Y), is a highly effective inhibitor of eIF4E, a key protein involved in immunosuppression. By targeting immune checkpoint proteins such as PD-1, PD-L1, LAG3, TIM3, and IDO, eIF4E-IN-1 functions to disrupt immune suppression and promote immune release in specific diseases such as cancer and infectious diseases. | |||
T35524 |
(1S)-Calcitriol
|
||
(1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3). (1S)-Calcitriol exhibits potent vitamin D receptor (VDR)-mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion[1]. 3‐epi‐Calcitroic acid is an end product of (1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3; 3‐epi‐1a,25(OH)2D3) metabolism by rat CYP24A1[1]. [1]. Steve Y Rhieu, et al. Metabolic stability of 3-epi-1α,25-dihydr... | |||
T81144 | SMP-93566 | ||
SMP-93566为一抗体-药物偶联物(Antibody-Drug Conjugates (ADCs)),其有效载荷(payload)脱落率低,可在体内抑制卵巢癌、胃癌及乳腺癌肿瘤。 | |||
T76328 |
Oxyntomodulin (swine)
|
||
Oxyntomodulin (swine) 是一种肽类激素,在餐后状态下从肠道释放,作为GLP-1R(GLP-1 受体) 和GCGR(胰高血糖素受体) 的双重激动剂,能够抑制食欲并减少食物摄入。 | |||
TP1916 |
[D-Phe12,Leu14]-Bombesin
|
||
Bombesin receptor antagonist that inhibits bombesin binding to rat brain with an IC50 value of 2 μM. Inhibits amylase release in vitro (IC50 = 4 μM) and attenuates bombesin-mediated suppression of food intake in vivo. | |||
T61794 | LASSBio-1632 | ||
LASSBio-1632 is a novel anti-asthmatic lead candidate that selectively inhibits PDE4A and PDE4D isoenzymes, leading to the suppression of airway hyper-reactivity (AHR) and TNF-α production in lung tissue. With high experimental BBB permeability, LASSBio-1632 (7j) efficiently crosses the blood-brain barrier through passive diffusion [1]. | |||
T79840 |
Bocodepsin hydrochloride
OKI-179 hydrochloride |
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Bocodepsin hydrochloride (OKI-179) 是一种口服活性的选择性HDAC抑制剂,具抗肿瘤特性,适用于治疗实体瘤和血液系统恶性肿瘤。 | |||
T72562 | Antiviral agent 23 | ||
Antiviral agent 23 是肠病毒 71 (EV71) 的抗病毒剂,EC50值为 94 nM。Antiviral agent 23 有效抑制 METTL3/METTL14 的活性。Antiviral agent 23 可用于感染的研究。 | |||
T76004 |
Super-TDU TFA
|
||
Super-TDU TFA 是一种特异性的 YAP 拮抗剂,可以靶向 YAP-TEAD 相互作用。Super-TDU TFA 可以抑制胃癌小鼠模型的肿瘤生长。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5788 |
XYLOBIOSE
|
IL Receptor; TNF | Apoptosis; Immunology/Inflammation |
Xylobiose 是一种木糖单体的二糖,单体之间具有 β-1, 4 键。 | |||
T6S0214 |
dl-Maackiain
(+)-Maackiain,高丽槐素,Demethylpterocarpin |
Apoptosis; Parasite | Apoptosis; Microbiology/Virology |
dl-Maackiain (Demethylpterocarpin) 是分离自Maackia amurensis Rupr.et Maxim 的一种杀幼虫剂,针对埃及伊蚊,其LD50为 21.95 μg/ ml。 | |||
T6S1367 |
Procyanidin B2
原花青素 B2,Proanthocyanidin B2 |
Reactive Oxygen Species; NOD | Immunology/Inflammation; Metabolism; NF-κB |
Procyanidin B2 (Proanthocyanidin B2) 是天然黄酮类物质,具有抗肿瘤,抗氧化等活性。 | |||
T6S1141 |
Ganoderic acid A
灵芝酸 A,灵芝酸A |
Apoptosis; NF-κB; Endogenous Metabolite; Autophagy | Apoptosis; Autophagy; Metabolism; NF-κB |
Ganoderic acid A 能够抑制 JAK-STAT3信号通路,也能抑制细胞增殖,存活率和 ROS。 它对人骨肉瘤 HOS 和MG-63细胞具有增殖抑制、凋亡和侵袭抑制作用。 | |||
T1721 |
2'-Deoxyuridine
Uracil deoxyriboside,2-deoxyuridine,2'-dU,2'-脱氧尿苷 |
Others; DNA/RNA Synthesis; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others |
2'-Deoxyuridine (2-deoxyuridine) 可以促使染色体断裂,从而抑制 thymidylate 的合成活性,它也是合成 Edoxudine 的前体。 | |||
T5665 |
Geraniol
|
Others; Endogenous Metabolite; Antifungal | Metabolism; Microbiology/Virology; Others |
Geraniol 对糖尿病引起的心脏功能障碍起保护作用,抑制氧化应激。 | |||
T5785 |
MALTOTETRAOSE
Fujioligo 450,Amylotetraose,α-1,4-Tetraglucose,麦芽四糖 |
TNF; Endogenous Metabolite | Apoptosis; Metabolism |
Maltotetraose (Fujioligo 450) 能够作为生物流体中酶联测定淀粉酶特性的底物。 | |||
TN1410 |
Asperulosidic acid
ASPA,车叶草苷酸 |
ERK; NF-κB | MAPK; NF-κB |
Asperulosidic acid (ASPA) 是从白花蛇舌草药中提取的一种环烯醚萜苷,具有抗肿瘤、抗氧化和抗炎作用。它通过抑制 NF-κB 和丝裂原活化蛋白激酶信号通路抑制炎性细胞因子释放发挥抗炎作用。 | |||
TN1712 |
Gossypin
|
NF-κB; S6 Kinase | MAPK; NF-κB; PI3K/Akt/mTOR signaling |
Gossypin 是一种从Hibiscus vitifolius 中分离得到的黄酮,能够抑制NF-κB 和 NF-κB 的调节基因表达。在小鼠原代骨髓细胞和 RAW264.7 细胞中,它也可抑制 RANKL 诱导的破骨细胞形成。它具有抗氧化、抗炎、抗癌、抗衰老、抗糖尿病和保护肝脏的活性。 | |||
T5S1000 |
Sophoraflavanone G
Kushenol F,槐黄烷酮 G,Vexibinol |
Apoptosis | Apoptosis |
Sophoraflavanone G (Kushenol F) 是从苦参中提取到的一种天然产物,通过抑制 MAPK 相关通路诱导 MDA-MB-231 和 HL-60 细胞凋亡,具有抗肿瘤和抗炎特性。 | |||
T0603 |
Phthalic acid mono-2-ethylhexyl ester
Phthalic Acid Monooctyl Ester,邻苯二甲酸单乙基己基酯 |
P450; Endogenous Metabolite | Metabolism |
Phthalic acid mono-2-ethylhexyl ester (Phthalic Acid Monooctyl Ester) 是diethylhexyl phthalate (DEHP) 的主要生物活性代谢物,能够抑制 CYP17 的 17,20 裂合酶特性。 | |||
TN1923 |
Mesaconine
|
IL Receptor; NF-κB | Immunology/Inflammation; NF-κB |
Mesaconine 是来自 Aconitum carmichaelii Debx 的一种成分。Mesaconine 具有心脏作用和抗 NF-κB 活性。 Mesaconine 可能是麻黄附子细辛汤抗炎和免疫抑制的部分物质基础。 | |||
T1313 |
Nitrofurantoin
Furadantine,呋喃妥因,Macrodantin,Furadonine |
Antibacterial; Antibiotic | Microbiology/Virology |
Nitrofurantoin (Furadantine) 是一种具有口服活性的广谱内酰胺酶抗菌剂。它是一种抗生素,可研究尿路感染。 | |||
T3727 |
Methyl syringate
Syringic Acid Methyl Ester,丁香酸甲酯 |
TRP/TRPV Channel | Membrane transporter/Ion channel |
Methyl syringate (Syringic Acid Methyl Ester) 是水仙花蜜的化学标记物,是有效的细菌和真菌漆酶酚介质。它也是TRPA1激动剂。 | |||
T6717 |
Vanillin
Lioxin,m-Methoxy-p-hydroxybenzaldehyde,香草醛,Zimco,p-Vanillin,p-Hydroxy-m-methoxybenzaldehyde,香兰素,FEMA 3107 |
Others; Endogenous Metabolite | Metabolism; Others |
Vanillin (Zimco) 是一种天然产物,是从香草豆中提取的单个分子,是香水,食品和药物中广泛使用的气味。 | |||
T3524 |
Halofuginone hydrobromide
卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐 |
Others; Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Others; Stem Cells |
Halofuginone hydrobromid 是Febrifugine 的衍生物,是竞争性脯氨酰-tRNA 合成酶抑制剂。它是 I 型胶原合成的特异性抑制剂,并通过抑制TGF-β活性可减轻骨关节炎。它具有抗疟疾、抗炎、抗癌、抗纤维化作用。 | |||
TN1664 |
Ganoderic acid H
|
NF-κB; DNA/RNA Synthesis; CDK | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; NF-κB |
Ganoderic acid H 是一种羊毛脂烷型三萜,提取自灵芝中。它能够抑制转录因子AP-1 和 NF-kappaB 信号,并抑制乳腺癌细胞细胞的生长和入侵。 | |||
T5S0993 |
Kurarinone
苦参酮,苦参黄素 |
BCL; Others; IκB/IKK; TNF; NF-κB; JAK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; Others; Stem Cells |
Kurarinone 是从灌木苦参中提取的黄酮类化合物,具有抗肿瘤、雌激素和抗炎活性,对免疫反应也有很强的抑制作用。 | |||
T3S0645 |
N-trans-Feruloyltyramine
Feruloyltyramine,N-Feruloyltyramine,Moupinamide,N-反式阿魏酰酪胺 |
Others; COX | Immunology/Inflammation; Neuroscience; Others |
N-trans-Feruloyltyramine (Feruloyltyramine) 是从大麻中分离得到的一种生物碱,是COX1和COX2的抑制剂,具有抗氧化和抗炎活性。 | |||
T4S1616 |
Sanggenon D
桑根酮D,Sanggenone D |
NOS; COX; GABA Receptor | Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience |
Sanggenone D represents a new scaffold of positive GABAA receptor modulators, it also inhibits COX-2 activity (IC 50 = 73-100 μM). Sanggenone D has anti-inflammatory activity, it can inhibit NO production from lipopolysaccharide (LPS)-induced RAW 264.7 ce | |||
TN1557 |
Decursinol angelate
|
ERK; VEGFR; PKC; JNK | Angiogenesis; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; Tyrosine Kinase/Adaptors |
Decursinol angelate 是从朝鲜当归根部分离得到的一种天然产物,是 PKC 激酶的激活剂,有细胞毒性,抗肿瘤和抗炎活性。 | |||
T6S0077 |
Byakangelicol
|
COX | Immunology/Inflammation; Neuroscience |
Byakangelicol 是一种分离自白芷的白三醇,能够抑制环加氧酶-2的表达及活性,从而减少白细胞介素-1β诱导的 A549 细胞中前列腺素 E2 的释放。它可用于研究气道炎症。 | |||
T4928 |
L-Kynurenine
L-犬尿氨酸,(S)-Kynurenine |
AhR; Aryl Hydrocarbon Receptor; Endogenous Metabolite | Immunology/Inflammation; Metabolism |
L-Kynurenine ((S)-Kynurenine) 是L-色氨酸的代谢物,是芳香烃受体激动剂,可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。 | |||
T2854 |
Phillyrin
Forsythin,连翘苷 |
P450; Influenza Virus; AMPK | Chromatin/Epigenetic; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling |
Phillyrin (Forsythin) 是从连翘中分离出来的一种天然产物,具有抗甲型流感病毒的活性,以及抗菌和消炎作用。 | |||
T4S1050 |
Pristimerin
扁塑藤素,Celastrol methyl ester |
NF-κB; Antibacterial | Microbiology/Virology; NF-κB |
Pristimerin (Celastrol methyl ester) 是一种可逆的单酰基甘油脂肪酶高效抑制剂,IC50值为93 nM。 | |||
T4S1469 |
Cucurbitacin IIb
葫芦素IIB,雪胆素乙 |
Apoptosis; Others | Apoptosis; Others |
Cucurbitacin IIb 是一种雪胆中的活性成分。它阻碍 STAT3,JNK 和 Erk1/2 的磷酸化,提高 IκB 和 NF-κB (p65) 的磷酸化水平,抑制 NF-κB (p65) 的核转位,降低 IκBα 和 TNF-α 的 mRNA 水平。它能够诱导细胞凋亡,具有抗炎作用。 | |||
T3S1416 |
Decursin
Decursinol angelate,前胡素,(+)-Decursin,紫花前胡素 |
Apoptosis; PKC | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling |
Decursin (Decursinol angelate) 是一种细胞毒性剂,是一种来自朝鲜当归根的有效蛋白激酶 C 激活剂。它通过 Hippo/YAP 信号通路抑制 HepG2 细胞的生长。它通过下调 CXCR7 表达来抑制胃癌中的肿瘤生长,迁移和侵袭。 | |||
T3S1471 |
Cucurbitacin IIA
葫芦素Iia,Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA |
Apoptosis; Survivin | Apoptosis |
Cucurbitacin IIA (Dihydrocucurbitacin Q1) 是从园果雪胆中分离得到的一种三萜烯,可诱导细胞凋亡和增强自噬,有助于葫芦素IIA 对炎症相关疾病的抗炎活性。它可降低癌细胞中生存素的表达,降低磷酸化组蛋白 H3 的水平,增加裂解的 PARP 的水平。 | |||
T4518 |
Licochalcone D
|
ERK; NF-κB | MAPK; NF-κB |
Licochalcone D 是一种 NF-κB p65的有效抑制剂,是一种存在于 Glycyrrhiza inflate 中的黄酮类化合物,具有抗氧化、抗炎、抗癌等作用。 | |||
T3417 |
Amentoflavone
Didemethyl-ginkgetin,穗花杉双黄酮,Amenthoflavone,3',8''-Biapigenin |
Apoptosis; P450; Phospholipase; Reactive Oxygen Species; Opioid Receptor; COX; Antibacterial; RSV; Antifungal | Apoptosis; Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB |
Amentoflavone (3',8''-Biapigenin) 是一种具有很多生物活性的双黄酮类天然产物,有抗炎、抗氧化和神经保护等作用。 | |||
T5S2358 |
Dehydrocorydaline
Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine |
BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome |
Dehydrocorydaline (13-Methylpalmatine) 是一种生物碱。它调节Bax,Bcl-2蛋白表达,激活caspase-7,caspase-8,并使PARP 失活。它能增强p38 MAPK 活化,具有抗炎、抗癌等功效。它具有强大的抗疟疾作用,并具低细胞毒性。 | |||
T3229 |
Cytochalasin D
|
ATPase; p38 MAPK; Calcium Channel; Akt; PI3K | Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling |
Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibit | |||
T5S1632 |
Barlerin
8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01 |
VEGFR; TNF; NF-κB; Akt; Caspase | Angiogenesis; Apoptosis; Cytoskeletal Signaling; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Barlerin (8-O-Acetylshanzhiside methyl ester) 是一种环孢菌素葡萄糖苷,从中国西藏民间药用植物中分离得到,能够抑制NF-κB 活性。 | |||
T4S2326 |
Cornuside
7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside |
ERK; p38 MAPK; NF-κB; JNK | MAPK; NF-κB |
Cornuside (Comuside) 是从山茱萸的果实中分离出的环烯醚萜苷,可用于炎症疾病的研究和促进血液循环。 它通过下调 MAPK 和 NF-κB 信号通路抑制肥大细胞介导的过敏反应,用于炎性过敏性疾病中的潜能。 | |||
T5S2343 |
Acetylshikonin
乙酰紫草素,Acetyl shikonin |
Others; P450; AChE | Metabolism; Neuroscience; Others |
Acetylshikonin 来源于紫草根,具有抗癌、抗炎作用。它是一种 AChE 抑制剂,具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂,对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。 | |||
T3S0027 |
Picropodophyllotoxin
AXL 1717,Picropodophyllin,苦鬼臼毒素 |
IGF-1R | Tyrosine Kinase/Adaptors |
Picropodophyllotoxin (AXL 1717) 是一种环木脂素生物碱,存在于五月树(Podophyllum peltatum) 中,是一种具有潜在抗肿瘤活性的胰岛素样生长因子 1 受体 (IGF1R) 的小分子抑制剂。它特异性抑制 IGF1R 的活性并下调细胞表达,而不干扰其他生长因子受体的活性,例如胰岛素受体、表皮生长因子、血小板衍生生长因子、成纤维细胞生长因子和肥大/干细胞生长因子 (KIT) )。该药剂在抑制肿瘤细胞增殖和诱导肿瘤细胞凋亡方面显示出有效的活性。 IGF1R 是一种在多种人类癌症中过度表达的受体酪氨酸激酶,在多种癌细胞的生长和存活中起关键作用。 | |||
TN4938 |
Samidin
|
p38 MAPK; TNF; NF-κB; COX; DNA/RNA Synthesis; JNK | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Neuroscience; NF-κB |
Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. | |||
TN4633 |
Neocryptotanshinone II
|
NOS; NF-κB | Immunology/Inflammation; NF-κB |
Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways. | |||
TN4418 | Lasiodiplodin | ATPase; TNF | Apoptosis; Membrane transporter/Ion channel |
Lasiodiplodin may have potential anti-inflammatory activity, it shows moderate suppression effects on induced NO production. Lasiodiplodin inhibits electron transport chain. | |||
TN2507 |
1,6,7-Trihydroxyxanthone
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
1,6,7-Trihydroxyxanthone has anti-cancer activity ,at least in part, through the activation of miR-218 and suppression of Bmi-1 expression; can suppress cell growth and induce apoptosis in liver cancer cells. | |||
TN4390 |
Kihadanin B
|
Akt; PPAR; FOXO1 | Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling |
Kihadanin B can repress the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes. | |||
TN6547 |
Angustifoline
鲁冰花 |
||
Angustifoline has activity against gram-positive bacteria. It inhibits human colon cancer cell growth by inducing autophagy along with mitochondrial-mediated apoptosis, suppression of cell invasion and migration and stimulating G2/M cell cycle arrest. | |||
TN3618 |
Cedrin
|
Beta Amyloid; BCL; Caspase | Apoptosis; Neuroscience; Proteases/Proteasome |
Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative stress, improvement of mitochondrial dysfunction and suppression of apoptosis. | |||
TMA0003 | Trans-caffeic acid | cAMP; Tyrosinase | GPCR/G Protein; Proteases/Proteasome |
Trans-caffeic acid stearyl ester is posited to inhibit melanogenesis signaling while suppressing cAMP levels and, subsequently, MC1R, MITF, tyrosinase, TRP-2 and TRP-1 down-regulation, resulting in the suppression of tyrosinase activity, DOPA oxidase activity and melanin synthesis. | |||
TN1615 |
Epitheaflagallin 3-O-gallate
表没食子儿茶素没食子酸酯 |
MMP | Proteases/Proteasome |
Epitheaflagallin 3-O-gallate is a promising functional food material with potential antiobesity and antiperiodontal disease activities, it suppresses tumor growth through the suppression of angiogenesis. | |||
TN6608 |
Cyanidin-3-O-arabinoside chloride
|
||
Cyanidin-3-O-arabinoside chloride has antioxidant activity. It reduces the peroxynitrite-induced suppression of mitochondrial respiration, DNA damage, PARS activation and vascular dysfunction in HUVECs. | |||
TN1374 |
α-Chaconine
alpha-Chaconine,卡茄碱,阿尔法卡茄碱 |
IL Receptor; COX; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Neuroscience |
Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. Alpha-Chaconine also has cytotoxic effects. | |||
TMA0291 | Dehydroglyasperin D | GSK-3; p38 MAPK; ROS; Akt; COX; PI3K; DNA/RNA Synthesis; Prostaglandin Receptor; JNK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; Neuroscience; PI3K/Akt/mTOR signaling; Stem Cells |
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction with phosphatidylinositol 3-kinase; it also mediates suppression of both COX-2 expression and the MLK3 signalling pathway through direct binding and inhibition of MLK3. Dehydroglyasperin D shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet o... | |||
T39918 |
(±)-Phrymarolin II
|
||
(±)-Phrymarolin II is a promising new class of plant virus (tobacco mosaic virus) inhibitors. | |||
T39445 |
Korepimedoside C
Epimedin I,朝藿苷丙 |
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Korepimedoside C, also known as Epimedin I, is a flavonol glycoside derived from the aerial parts of Epimedium koreanum Nakai. Epimedium koreanum Nakai is a renowned Chinese herbal medicine that has been extensively studied for its potential in addressing impotence, osteoporosis, immune suppression, and cardiovascular diseases. | |||
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