Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gossypin 是一种从Hibiscus vitifolius 中分离得到的黄酮,能够抑制NF-κB 和 NF-κB 的调节基因表达。在小鼠原代骨髓细胞和 RAW264.7 细胞中,它也可抑制 RANKL 诱导的破骨细胞形成。它具有抗氧化、抗炎、抗癌、抗衰老、抗糖尿病和保护肝脏的活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 355 | 现货 | ||
5 mg | ¥ 485 | 现货 | ||
10 mg | ¥ 730 | 现货 | ||
25 mg | ¥ 1,190 | 现货 | ||
50 mg | ¥ 1,789 | 现货 | ||
100 mg | ¥ 2,678 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 513 | 现货 |
产品描述 | Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the NF-kappaB activation pathway, which may explain its role in the suppression of inflammation, carcinogenesis, and angiogenesis. |
体外活性 | Gossypin is a flavone extracted from Hibiscus vitifolius, which has been reported to exhibit anti-inflammatory, antioxidant, and anticancer activities.?However, the anticancer properties of gossypin and its molecular mechanism of action against gastric cancer have not been fully investigated.?gossypin is an Aurora kinase A (AURKA) and RSK2 inhibitor that suppresses gastric cancer growth.?Gossypin attenuated anchorage-dependent and anchorage-independent gastric cancer cell growth as well as cell migration.?Based on the results of in vitro screening and cell-based assays, gossypin directly binds to and inhibits AURKA and RSK2 activities and their downstream signaling proteins.?Gossypin decreased S phase and increased G2/M phase cell cycle arrest by reducing the expression of cyclin A2 and cyclin B1 and the phosphorylation of the CDC protein.?Additionally, gossypin also induced intrinsic apoptosis by activating caspases and PARP and increasing the expression of cytochrome c. Gossypin is an AURKA and RSK2 inhibitor that could be useful for treating gastric cancer[2]. |
分子量 | 480.38 |
分子式 | C21H20O13 |
CAS No. | 652-78-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (52.04 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.0817 mL | 10.4084 mL | 20.8169 mL | 52.0421 mL |
5 mM | 0.4163 mL | 2.0817 mL | 4.1634 mL | 10.4084 mL | |
10 mM | 0.2082 mL | 1.0408 mL | 2.0817 mL | 5.2042 mL | |
20 mM | 0.1041 mL | 0.5204 mL | 1.0408 mL | 2.6021 mL | |
50 mM | 0.0416 mL | 0.2082 mL | 0.4163 mL | 1.0408 mL |
中药材名称 | 中药材拉丁名 | 性 | 味 | 归经 |
地羊鹊 | Lotus corniculatus L. | 凉 | 甘, 微苦 | 肺, 胃 |
横根费菜 | Sedumkamtschaticum, Fisch | 平 | 酸 | 心, 肝, 脾 |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Gossypin 652-78-8 MAPK NF-Κb PI3K/Akt/mTOR signaling NF-κB S6 Kinase Antiinflammatory inhibit Nuclear factor-κB Inhibitor Antioxidant Anticancer cardiovascular,osteoclastogenesis Antiallergic Nuclear factor-kappaB Antiviral Analgesic inhibitor