230
44
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T83775 |
STING Agonist 12L
Stimulator of Interferon Genes Agonist 12L |
||
STING激动剂12L是一种刺激干扰素基因(STING)的激动剂。它与野生型STING结合(IC50 = 1.15 µM),以及STING的R232、AQ和Q变体(IC50分别为1.06、0.61和1.12 µM),并在THP-1和RAW 264.7细胞中诱导报告基因表达(EC50分别为0.38和12.94 µM)。STING激动剂12L (5 µM)在THP-1细胞中诱导IFNB1、CXCL10和IL6 mRNA的表达。在体内,STING激动剂12L (10 mg/kg)提高了血浆IFN-β水平,并且在B16/F10小鼠黑色素瘤模型中减少了肿瘤体积和肺转移灶的数量。 | |||
T9029 |
STING-IN-3
C-171 |
STING | Immunology/Inflammation |
STING-IN-3 (C-171) 是干扰素基因刺激物 (STING) 的抑制剂。 它与 STING 结合,抑制其棕榈酰化,并阻止 TBK1 的募集和磷酸化。 | |||
T83841 |
STING Agonist D61
D61,Stimulator of Interferon Genes Agonist D61 |
||
STING激动剂D61(D61)是干扰素基因刺激剂(STING)的激动剂。它在基于细胞的分析中诱导IFN3诱导的分泌性碱性磷酸酶(SEAP)报告基因和IFN-β诱导的报告基因的表达(EC50分别为52.9和116 nM)。D61(4, 6, 和8 µM)增加了编码IFN-β和化学因子(C-X-C基序)配体10(CXCL10)的mRNA的表达以及TANK结合激酶1(TBK1)、IRF3和STING在THP-1单核细胞中的磷酸化。在体内,D61(每隔一天0.25 mg/kg)在CT26小鼠结肠癌模型中减少肿瘤体积,而不影响体重。 | |||
T6828 |
ZL0420
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
ZL0420 是有效且选择性的 BET 溴结构域 4 (BRD4) 抑制剂,对 BRD4 的溴结构域 (BD) 具有纳摩尔结合亲和力。ZL0420 对 BRD4 BD1和 BRD4 BD2 的IC50分别为 27 nM 和 32 nM。 | |||
T13613 |
ChX710
|
STING | Immunology/Inflammation |
ChX710可以引发 I 型干扰素对细胞溶质 DNA 的反应,其特异性细胞干扰素刺激基因 (ISG) 诱导 ISRE 启动子序列和干扰素调节因子 (IRF) 3 的磷酸化。 | |||
T7329 |
C-178
|
STING | Immunology/Inflammation |
C-178 是 STING 选择性共价抑制剂,与 Cys91 结合抑制小鼠中由不同的激活剂引起的 STING 反应。 | |||
T13015 |
STING agonist-4
|
STING | Immunology/Inflammation |
STING agonist-4 是 是干扰素基因 (STING) 受体刺激剂的激动剂,IC50为 20 nM。 | |||
T5674 |
H-151
|
STING | Immunology/Inflammation |
H-151 是一种 STING 拮抗剂,具有高效性和选择性。H-151 与 STING 的 Cys91 共价结合,抑制 Cys91 的棕榈酰化,从而抑制 STING 的活性。H-151 可用于体内外自身炎症性疾病的研究。 | |||
T9853 |
STING activator Compound 53
|
STING | Immunology/Inflammation |
基于 oxindole 核心结构的 STING activator Compound 53 在永生化细胞和原代细胞中表现出强大的 STING(人 EC50 185 nM)的靶向功能激活以及与 STING 激活一致的细胞因子诱导指纹。 | |||
T9554 |
SN-008
|
STING | Immunology/Inflammation |
SN-008 是 SN-011 的低活性类似物,可作为阴性对照。 | |||
T8798 |
MSA-2
|
STING | Immunology/Inflammation |
MSA-2 是可口服的非核苷酸 STING 激动剂,以具有纳摩尔亲和力的非共价二聚体形式与 STING 结合。它在同基因小鼠肿瘤模型中显示抗肿瘤活性,与抗 PD-1 协同作用,可刺激肿瘤分泌干扰素-β,诱导肿瘤消退,具有持久的抗肿瘤免疫。 | |||
T5154 |
C-176
C176,STING inhibitor 1 |
STING | Immunology/Inflammation |
C-176 (STING inhibitor 1) 是干扰素基因刺激受体的一种强效共价抑制剂。 | |||
T5516 |
diABZI STING agonist-1 trihydrochloride
|
STING | Immunology/Inflammation |
diABZI STING agonist-1 trihydrochloride 是选择性的干扰素基因刺激受体(STING)激动剂,在人和小鼠中的 EC50值分别为 130 和 186 nM。 | |||
T6919 |
Omaveloxolone
RTA-408 |
Apoptosis; Others; Nrf2; STING | Apoptosis; Immunology/Inflammation; Others |
Omaveloxolone (RTA-408) 是一种抗氧化炎症调节剂,可激活Nrf2并抑制一氧化氮。它通过抑制 STING 依赖的 NF-κb 信号通路,来抑制破骨细胞的生成。 | |||
T8655 |
SR-717
|
STING | Immunology/Inflammation |
SR-717 是一种 cGAMP 的类似物,一种非核苷类 STING 激动剂,可以诱导 STING 形成“封闭”的激活构象。SR-717 具有抗肿瘤活性,可以促进免疫细胞的激活以及抗原的交叉提呈。 | |||
T9028 |
STING-IN-2
C-170 |
STING | Immunology/Inflammation |
STING-IN-2 (C-170) 是一种 STING 共价抑制剂,可抑制小鼠 STING (mmSTING) 和人类 STING (hsSTING),可用于自身炎症性疾病的研究。 | |||
T8328 |
STING agonist-1
G10 |
Virus Protease; STING | Immunology/Inflammation; Microbiology/Virology |
STING agonist-1 (G10)是一种人类特异性 STING 激动剂,可引发针对新兴甲病毒的抗病毒活性。它抑制甲病毒属 VEEV 复制,IC90值为 24.57 μM。 | |||
T10252L2 |
ADU-S100 ammonium salt
ML RR-S2 CDA ammonium salt,MIW815 ammonium salt |
STING | Immunology/Inflammation |
ADU-S100 ammonium salt (ML RR-S2 CDA ammonium salt) 是干扰素基因刺激物的激活剂。 ADU-S100 ammonium salt 可导致有效的全身性肿瘤消退和免疫。 | |||
T0947 |
Dexamethasone acetate
Dexamethasone 21-acetate,醋酸地塞米松,Dexamethason acetate,NSC 39471 |
Glucocorticoid Receptor; Mitophagy; IL Receptor; Annexin A; NOS; Antibacterial; Autophagy | Autophagy; Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology |
Dexamethasone acetate (NSC 39471) 是一种糖皮质素类甾体,有抗炎和免疫抑制活性。它可研究眼部感染。 | |||
T9137 |
SN-011
[1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-,GUN35901 |
STING | Immunology/Inflammation |
SN-011 (GUN35901) 是选择性 STING 抑制剂,可与环状二核苷酸 (CDN) 竞争 STING 二聚体的结合口袋,从而阻断 CDN 结合和 STING 激活。它用于 STING 驱动的自身免疫和炎症性疾病的研究,抑制 STING 信号传导的 IC50值为 76 nM。 | |||
T7081 |
CCCP
Carbonyl Cyanide m-Chlorophenylhydrazone,Carbonyl cyanide 3-chlorophenylhydrazone,羰基氰化氯苯腙 |
Apoptosis; IκB/IKK; COX; Mitochondrial Metabolism; STING; IFNAR; Antibacterial | Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB |
CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) 是一种氧化磷酸化 (OXPHOS) 抑制剂,线粒体质子载体解偶联剂。CCCP 抑制 STING 及其下游信号分子 TBK1 和 IRF3 的激活。 | |||
T6273 |
Vadimezan
DMXAA,伐地美生,5,6-Dimethylxanthenone-4-acetic Acid,NSC 640488,ASA-404 |
Influenza Virus; VDA; STING; IFNAR | Angiogenesis; Immunology/Inflammation; Microbiology/Virology |
Vadimezan (DMXAA) 是一种血管破坏剂,一种鼠 STING 激动剂,也是一种细胞因子如 I 型 IFN 的诱导剂。Vadimezan 具有抗肿瘤活性,可以诱导肿瘤中的血流快速停止,但不影响正常组织中的血流。 | |||
T16269 |
Nanaomycin A
|
DNA Methyltransferase; Dehydrogenase; Parasite | Chromatin/Epigenetic; Metabolism; Microbiology/Virology |
Nanaomycin A 是一种醌类抗生素,可重新激活人类癌细胞中沉默的肿瘤抑制基因。 Nanaomycin A 是 DNMT3B 的特异性抑制剂 (IC50 = 500 nM)。 | |||
T71722 |
Angiogenesis inhibitor BT2
|
||
Angiogenesis inhibitor BT2 is a novel inhibitor of angiogenesis and vascular permeability, inhibiting ERK phosphorylation and the expression of FosB/ΔFosB, VCAM-1, and many genes involved in proliferation, migration, angiogenesis, and inflammation, interacting with MEK1, suppressing retinal CD31, pERK, VCAM-1, and VEGF-A165 expression. | |||
T74217 | Angiogenesis agent 1 | HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism |
Angiogenesis agent 1 (compound C-31) 为红景天苷衍生的糖苷类似物,能激活 HIF-1α 通路。该化合物有助于研究糖尿病所致后肢缺血。 | |||
T74627 |
Angiogenesis inhibitor 3
|
||
Angiogenesis inhibitor 3 (compound 8) 是一种有效的血管生成(angiogenesis)抑制剂,能够抑制HUVEC和HCT-15细胞增殖,其IC50值分别为1.00和0.71 μM。此外,此化合物还能诱导这两种细胞的凋亡(apoptosis)并具有抑制癌细胞侵袭的抗癌活性。Angiogenesis inhibitor 3还能够抑制斑马鱼胚胎的血管生成。 | |||
T83116 |
Angiogenesis inhibitor 4
|
||
Angiogenesis Inhibitor 4为一种高效血管生成抑制剂,主要应用于癌症研究领域。 | |||
T19853 |
Dimethoxycurcumin
Veratrylcurcuminoid,二甲氧基姜黄素 |
Others | Others |
Dimethoxycurcumin (Veratrylcurcuminoid) 是 curcumin 衍生物,拥有抗氧化及抗炎作用。 | |||
T3685 |
SR9009
Stenabolic,REV-ERB Agonist II |
Autophagy | Autophagy |
SR9009 (Stenabolic) 是一种REV-ERBα/β激动剂,可增加由 REV-ERBα/ERBβ 调节的基因的组成性抑制,IC50分别为 670 nM 和 800 nM。 | |||
T23351 |
Shz 1
|
Others | Others |
Shz-1在 P19CL6 细胞中诱导各种心脏特异性基因,包括肌节原肌球蛋白,在小鼠中诱导 Nkx2.5 表达。Shz-1 在 C2C12 细胞中激活轴突 TPM4 启动子驱动的异位表达。 | |||
T2707 |
Pifithrin-α hydrobromide
Pifithrin hydrobromide,Pifithrin-α (PFTα) HBr,Pifithrin-α,PFTα,PFTα hydrobromide |
Ferroptosis; Aryl Hydrocarbon Receptor; p53 | Apoptosis; Immunology/Inflammation |
Pifithrin-α hydrobromide (Pifithrin-α hydrobromide) 是一种 p53 抑制剂,可抑制 p53 反应基因的 p53 依赖性反式激活。它也是芳烃受体的激动剂。 | |||
T3106 |
C-DIM12
|
Apoptosis; Others | Apoptosis; Others |
C-DIM12是一种人工合成的Nurr1激活剂,可诱导Nurr1和DA 基因表达。 | |||
T6889 |
MI-136
|
Apoptosis; Epigenetic Reader Domain; Androgen Receptor | Apoptosis; Chromatin/Epigenetic; Endocrinology/Hormones |
MI136 是 menin-MLL(PPI) 蛋白互作的抑制剂,其 IC50值为31 nM,Kd 值为23.6 nM。它可抑制 DHT 诱导的雄激素受体 (AR) 靶基因的表达,有用于去势抵抗性肿瘤的潜能。 | |||
T22884 |
JW 67
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
JW 67 是典型 Wnt 信号通路的抑制剂,IC50为 1.17 μM。它影响由 β- 连环蛋白/GSK-3β/AXIN/APC/CK1 组成的多蛋白复合物,快速降低活性 β- 连环蛋白,随后下调Wnt 靶基因。它也抑制结直肠癌细胞生长。 | |||
T9980 |
AVJ16
|
IGF-1R | Tyrosine Kinase/Adaptors |
AVJ16作为胰岛素生长因子2 mRNA 结合蛋白家族的成员,可与某些基因的mRNA 结合来调节蛋白质翻译。 | |||
T62356 |
Mardepodect hydrochloride
PF-2545920 HCl,Mardepodect HCl,MP-10 HCl,PF-02545920 HCl |
Apoptosis; PDE | Apoptosis; Metabolism |
Mardepodect hydrochloride (Mardepodect HCl) 是一种可穿过血脑屏障且具有口服活性的、选择性和高效性的 PDE10A 抑制剂(IC50 :0.37 nM)。Mardepodect hydrochloride 可上调编码特定生长因子、转录因子、细胞信号分子和细胞表面蛋白的基因,同时下调广泛的可靶向细胞周期和细胞凋亡相关基因。 | |||
T60008 |
BCL6-IN-6
|
BCL | Apoptosis |
BCL6-IN-6 是 Bcl-6 的抑制剂,可用于关于弥漫性大 B 细胞淋巴瘤的研究。 BCL6-IN-6 阻断 Bcl-6 与其辅阻遏物的相互作用,并以剂量依赖性方式重新激活 Bcl-6 靶基因。 | |||
T11035 |
diABZI STING agonist-1 (Tautomerism)
diABZI STING agonist (Compound 3) |
STING | Immunology/Inflammation |
diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) 是一个选择性的干扰素基因刺激受体 (STING) 的激动剂,其在人和小鼠中的 EC50 值分别为 130 nM 和 186 nM。。 | |||
T2003 |
ISX-9
Isoxazole 9,Isoxazole 9 (ISX-9) |
Calcium Channel; Wnt/beta-catenin | Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Stem Cells |
ISX-9 (Isoxazole 9) 是一种神经干细胞分化的有效诱导剂,可诱导 Notch 激活的心外膜衍生细胞(NEC) 的心肌分化。它可通过电压门控的 Ca2+通道和 NMDA 受体来激活 Ca2+流入,并增加 NeuroD 表达。 | |||
T8710 |
MSAB
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
MSAB 是一种Wnt/β-catenin 信号传导的选择性抑制剂。它能够与 β-catenin 结合,诱导其降解,并能够下调 Wnt/β-catenin 靶基因。它对 Wnt 依赖性癌细胞表现出有效的抗肿瘤特性。 | |||
T73322 |
TBK1-IN-1
|
IκB/IKK | NF-κB |
TBK1-IN-1 是一种具有特异性和高效性的 TANK 结合激酶 1 (TBK1) 抑制剂(IC50: 22.4 nM),具有抗癌活性。TBK1-IN-1 对 TBK1 下游靶基因 cxcl10 和 ifnβ 的表达有抑制作用。 | |||
T20525 |
Chloramphenicol palmitate
|
Antibacterial; Antibiotic | Microbiology/Virology |
Chloramphenicol palmitate 是一种广谱抗生素,对革兰氏阳性和革兰氏阴性细菌具有活性。 Chloramphenicol palmitate 可用于在含有氯霉素抗性基因的转化细胞中作为细菌选择剂的研究。 | |||
T16007 |
MALAT1-IN-1
|
Others | Others |
MALAT1-IN-1 是Malat1(转移相关的肺腺癌转录本 1) 的特异性抑制剂。它能够以剂量依赖性方式调节Malat1下游基因,但对Neat1(富核丰富转录本 1) 的表达无影响。 | |||
T38766L |
Histone H3 (1-35) acetate
|
Others | Others |
Histone H3 (1-35) acetate 是组蛋白 H3 的 35 个残基肽。组蛋白 H3 是一种重要的蛋白质,在基因的动态和长期调控中发挥作用。 | |||
T39584 |
MI-3454
|
||
MI-3454 is a highly potent, orally active, and selective inhibitor of the interaction between menin and MLL1, with an IC50 of 0.51 nM. This compound effectively inhibits the proliferation of leukemic cells and promotes their differentiation, leading to the regression or complete remission of leukemia in mouse models featuring MLL1 rearrangements or NPM1 mutations. This remarkable therapeutic effect is achieved through the downregulation of key genes involved in the development of leukemia. | |||
T4005 |
FDI-6
FDI6,FDI 6 |
Others | Others |
FDI-6 是FOXM1抑制剂。它能够作用于 MCF-7 乳腺癌细胞中,直接与 FOXM1 蛋白结合,从靶基因组中取代 FOXM1,并诱导随后的转录下调。 | |||
T50049 |
4-Methylhistamine hydrochloride
|
Others | Others |
4-Methylhistamine hydrochloride 已被证明能抑制铜依赖性酶如酪氨酸酶和多巴胺β-羟化酶的活性,还被证明可以调节参与细胞周期调节和凋亡的基因的表达。 | |||
T8979 |
AEM1
|
Nrf2 | Immunology/Inflammation |
AEM1 是 Nrf2抑制剂,能够降低 A549 细胞中 Nrf2 依赖基因的表达,并在体外和体内抑制 A549 细胞的生长。 | |||
T3633 |
Crenigacestat
LY3039478 |
Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
Crenigacestat (LY3039478) 是一种口服具有活性的Notch 和γ-secretase 的抑制剂,其在多种肿瘤细胞中的IC50为 ∼1nM。 | |||
T72482 |
Dazostinag disodium
|
STING | Immunology/Inflammation |
Dazostinag disodium (TAK-676) 是一种新型干扰素基因刺激剂 (STING) 激动剂,也是一种免疫系统调节剂,具有抗肿瘤活性,可激活树突状细胞、自然杀伤细胞和 T 细胞。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5S1252 |
Prosapogenin A
重楼皂苷E,Progenin III |
Apoptosis; Others | Apoptosis; Others |
Prosapogenin A (Progenin III) 是藜芦中的一种天然产物,通过抑制 STAT3 信号通路和糖酵解,可诱导人癌细胞凋亡,有抗癌作用。 | |||
TN2331 |
Eleutheroside B1
刺五加苷B1 |
Influenza Virus | Microbiology/Virology |
Eleutheroside B1是具有广谱抗人流感病毒的一种香豆素。它抑制多种趋化因子基因和流感病毒核蛋白基因的 mRNA 表达。它具有抗病毒、抗流感和抗炎活性,且细胞毒性小。 | |||
T6S2123 |
Ginkgolic Acid
Romanicardic acid,Ginkgolic acid I,Ginkgolic acid (15:1),银杏酸C15:1,银杏酸,Ginkgolic acid C15:1 |
Others; E1/E2/E3 Enzyme | Others; Ubiquitination |
Ginkgolic Acid (Romanicardic acid) 是一种天然化合物, 在体外实验中抑制SUMOylation,IC50=3.0 μM。 | |||
T3976 |
Cytosporone B
Csn-B,Dothiorelone G |
Others | Others |
Cytosporone B (Dothiorelone G) 是一种天然存在的核孤儿受体Nur77/NR4A1激动剂(EC50=0.278 nM)。 | |||
T4S1796 |
Heterophyllin B
|
PI3K | PI3K/Akt/mTOR signaling |
Heterophyllin B 是一种活性环肽,从 Pseudostellaria heterophylla 中分离得到,可用于研究食管癌。 | |||
T1168 |
Desonide
Tridesilon,地索奈德,Locapred,Prednacinolone |
Glucocorticoid Receptor | Endocrinology/Hormones |
Desonide (Prednacinolone) 是一种非氟化皮质类固醇抗炎剂,能够作用于糖皮质激素受体。 | |||
TN1273 |
7,4'-Dihydroxyflavone
4',7-Dihydroxyflavone,7,4'-二羟基黄酮 |
NF-κB; COX; HDAC; CCR; NOD | Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB |
7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) 是从甘草中分离的类黄酮,是 eotaxin/CCL11抑制剂,抑制嗜酸性粒细胞趋化因子产生。它通过调节 NF-κB、STAT6 和 HDAC2,抑制 MUC5A 基因表达和粘液产生。 | |||
T6808 |
Coelenterazine
Oplophorus luciferin,Coelenteramine,腔肠素 |
Others | Others |
Coelenterazine (Coelenteramine) 是一种 apoaequorin 和 Renilla 荧光素酶的发光酶底物。它是超氧阴离子敏感化学发光探针,可用于检测过氧亚硝酸盐的化学发光。其中 Renilla 荧光素酶和底物 coelenterazine 被用作生物发光共振能量转移中检测蛋白质-蛋白质相互作用的生物发光供体。 | |||
TN4234 |
Hydrangenol
|
NOS; NF-κB; Nrf2; NO Synthase; Antifection; Autophagy | Autophagy; Immunology/Inflammation; Microbiology/Virology; NF-κB |
Hydrangenol 是一种天然产物,可从绣球花 (Hydrangea serrata) 的叶中分离。Hydrangenol 是口服有效的抗光老化化合物,可以预防皱纹的形成。Hydrangenol 可以降低 MMP 和炎症细胞因子的表达,增加保湿因子和抗氧化基因的水平。 | |||
TQ0216 |
Ercalcitriol
1α,25-Dihydroxy Vitamin D2 |
Others | Others |
Ercalcitriol (1α,25-Dihydroxy Vitamin D2) 是维生素 D2 的活性代谢物。 Ercalcitriol 作为维生素 D 的生理活化形式,通过调节正常细胞和转化细胞中的导管素抗菌肽 (CAMP) 和防御素 β-4 (DEFB4) 基因来增强免疫力,从而对抗病原体感染。 | |||
T0950 |
Neomycin sulfate
Framycin sulfate,硫酸新霉素 |
Phospholipase; ribosome; Antibacterial; Antibiotic | Metabolism; Microbiology/Virology |
Neomycin sulfate (Framycin sulfate) 是一种广谱的氨基糖苷类抗生素。Neomycin sulfate 可以阻断细菌蛋白质的合成以发挥抗菌活性。Neomycin sulfate 常用于筛选具有 Neo 抗性基因的原核和真核细胞。 | |||
T1022 |
Hygromycin B
潮霉素B,Hygrovetine |
ribosome; Antibacterial; Antibiotic; Antifungal | Microbiology/Virology |
Hygromycin B (Hygrovetine) 是一种氨基糖苷类抗生素,通过干扰易位并导致 70S 核糖体的错误翻译来抑制蛋白质合成。Hygromycin B 可用于筛选转染 hph 或 hyg 抗性基因的原核或者真核细胞。 | |||
T3363 |
Jervine
蒜黎芦碱,Iervin,11-Ketocyclopamine,Jerwiny |
Hedgehog/Smoothened; Smo | GPCR/G Protein; Stem Cells |
Jervine (Jerwiny) 是一种有效的刺猬 (Hh) 抑制剂(IC50:500-700 nM)。它是一种天然致畸性甾体生物碱,来自于 Veratrumalbum 的根茎,具有抗炎和抗氧化作用。 | |||
TWS1977 |
Kamebakaurin
尾叶香茶菜丙素,Kamebakaurine |
NF-κB | NF-κB |
Kamebakaurin (Kamebakaurine) 是一种提取自Isodon japonicus 中的天然产物,是一种NF-κB 的抑制剂,能够抑制 p50 的 DNA 结合活性。 | |||
T6S2246 |
Alisol B 23-acetate
Alisol B Acetate,Alisol B monoacetate,23-O-Acetylalisol B,23-Acetylalismol B,泽泻醇B乙酸酯 |
Others | Others |
Alisol B 23-acetate (Alisol B Acetate) 是三萜类化合物,能够激活法尼醇受体,诱导受损的肝脏再生。 | |||
T0034 |
Cortisone acetate
醋酸可的松,Cortisone 21-acetate,NSC 49420 |
Glucocorticoid Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Cortisone acetate (NSC-49420) 是 Cortisol(一种糖皮质激素)的氧化代谢产物。它在高浓度下能够部分干预 Glucocorticoid 与Glucocorticoid-receptor 的结合。它具有免疫抑制和消炎的作用。 | |||
T5S1805 |
5,7-Dihydroxychromone
5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮 |
Others; Virus Protease; PARP; Caspase; Nrf2 | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Others; Proteases/Proteasome |
5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) 是一种Cudrania tricuspidata 的提取物,通过激活 Nrf2/ARE 信号对 6-OHDA 诱导的氧化应激和细胞凋亡发挥神经保护作用。它抑制 6-OHDA 诱导的 SH-SY5Y 细胞中活化的caspase-3,caspase-9以及切割的PARP 表达。 | |||
T3864 |
Erianin
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BCL; Antibacterial | Apoptosis; Microbiology/Virology |
Erianin 能抑制吲哚胺-2,3-双加氧酶诱导的肿瘤血管生成,可用作退烧药和止疼剂。 | |||
T6S0119 |
Dauricine
蝙蝠葛碱 |
Apoptosis; Others; NF-κB | Apoptosis; NF-κB; Others |
Dauricine 是存在于北豆根粉末中的一种双苯异喹啉生物碱,具有抗炎活性。它通过抑制NF-κB 激活,剂量依赖性地抑制结肠癌细胞的增值和侵袭,并诱导凋亡。 | |||
T2915 |
Bardoxolone
RTA 401,齐墩果烷三萜化合物,CDDO |
Others; Nrf2 | Immunology/Inflammation; Others |
Bardoxolone (CDDO) 是新型核调节因子激活剂。 | |||
T0798 |
Triamcinolone
Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone |
Glucocorticoid Receptor; COX | Endocrinology/Hormones; Immunology/Inflammation; Neuroscience |
Triamcinolone (Aristocort) 是一种皮质类固醇激素受体激动剂,也是一种合成的长效糖皮质激素,具有抗炎活性。 | |||
T4S2126 |
Ginkgetin
银杏双黄酮,银杏素 |
Apoptosis; Wnt/beta-catenin; COX; STAT; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells |
Ginkgetin 是从银杏叶中分离得到的一种双黄酮,具有抗肿瘤、抗炎、神经保护、抗真菌的作用。它也是 Wnt 信号抑制剂,IC50值为 5.92 μM。 | |||
T6491 |
(-)-(S)-Equol
(−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol,雌马酚 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
(-)-(S)-Equol (4',7-Dihydroxyisoflavan) 是雌激素受体β的高亲和力配体。 | |||
TN1163 |
2'-Hydroxychalcone
|
Others | Others |
2'-Hydroxychalcone 是一种药物合成中间体,可用于合成黄酮类化合物。负载在纳米乳液中的2'-Hydroxychalcone 在Danio rerio 模型对副球孢子菌显示出杀真菌活性。2'-Hydroxychalcone 通过负载脂质的Hepg2细胞中的氧化应激诱导细胞毒性。2'-Hydroxychalcone 抑制通过逆转录聚合酶链反应确定的肿瘤坏死因子-α诱导ICAM-1,VCAM-1和E-选择素的稳态转录水平,因此可能会干扰其基因的转录。 | |||
T4S1551 |
Cinnamaldehyde
Cinnamic Aldehyde,肉桂醛 |
HIF | Angiogenesis; Chromatin/Epigenetic |
Cinnamaldehyde (Cinnamic Aldehyde) 具有解热作用。 它是镇静剂。它抑制MDA-MB-435S 细胞的侵袭能力与下调miR-27a 的表达有关。它诱导活性氧的产生,发挥血管扩张和抗癌作用。 它似乎是一种有希望的候选药物,可作为与 5-氟尿嘧啶 (5-FU) 和奥沙利铂 (OXA) 这两种用于 CRC 治疗的化疗药物联合治疗的辅助剂。其作用的可能机制可能涉及药物代谢基因的调节。 它在抑制黑色素瘤的发生和发展方面具有一定的作用,其作用机制可能表现为抑制VEGF 和HIF-α的表达,从而使血管模拟和黑色素瘤细胞新生血管的形成,促进肿瘤的生长。 | |||
TN4016 |
Ethyl 2,4,6-trihydroxybenzoate
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Liver X Receptor | Metabolism |
Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing lipid accumulation in HepG2 cells. It suppresses cellular cholesterol accumulation in a dose-dependent manner and induces the transcriptional activation of LXR-α/-β-responsive genes. | |||
TN4790 |
Pinobanksin 5-methyl ether
|
Others | Others |
Pinobanksin 5-methyl ether can induce detoxification genes. | |||
T23825 | Bryononic acid | ||
Bryononic acid is a new cucurbitane-type triterpenoid. Bryonolic acid transcriptional control of anti-inflammatory and antioxidant genes in macrophages in vitro and in vivo. | |||
T40667 | L-Azatyrosine | ||
L-Azatyrosine, an antitumor antibiotic derived from Streptomyces chibaensis, exhibits the ability to restore the normal phenotypic behavior of transformed cells that carry oncogenic Ras genes. | |||
T40529 |
(R)-(-)-1,2-Propanediol
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(R)-(-)-1,2-Propanediol is the (R)-enantiomer of 1,2-Propanediol, which is derived from glucose through the expression of NADH-linked glycerol dehydrogenase genes in Escherichia coli. | |||
TN2228 |
Soyasaponin Aa
大豆皂苷 AA,大豆皂苷Aa |
PPAR | DNA Damage/DNA Repair; Metabolism |
Soyasaponin Aa and soyasaponin Ab dose-dependently markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes, through the downregulation of the adipogenesis-related transcription factors PPARγ and C/EBPα± in 3T3-L1 adipo | |||
TN4938 |
Samidin
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p38 MAPK; TNF; NF-κB; COX; DNA/RNA Synthesis; JNK | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Neuroscience; NF-κB |
Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. | |||
T71896 |
Brevicompanine B
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Brevicompanine B is a fungal metabolite that has plant growth and circadian rhythm regulatory activity. Brevicompanine B inhibits primary root growth in Arabidopsis seedlings and disrupts the transcription of various genes involved in the regulation of plant circadian rhythm. It is active against P. falciparum. | |||
TN4383 |
Kazinol U
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IL Receptor; IκB/IKK; NOS; NF-κB | Immunology/Inflammation; NF-κB |
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-activity of estrogen receptor, transcriptional activity of estrogen -responsive element-reporter genes, it may have beneficial effects in the treatment of menopausal symptoms. | |||
T38331 |
Commendamide
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Commendamide is a natural bacterial product that was discovered in a screen for commensal bacteria effector genes (Cbegs). Cbeg12 is a bacterial effector gene that encodes for its production. Commendamide is structurally similar to long-chain N-acyl-amides, which commonly signal, in mammals, through G protein-coupled receptors. Commendamide activates GPR132 (also known as G2A) with an EC50 value of 11.8 μM. | |||
T75672 |
Angoline hydrochloride
|
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Angoline hydrochloride 是一种有效的、选择性的 IL6/STAT3信号通路抑制剂,IC50为 11.56 μM。Angoline hydrochloride 抑制STAT3磷酸化及其靶基因表达,并抑制癌细胞增殖。 | |||
TN3539 | Broussonin A | ERK; IL Receptor; IκB/IKK; NOS; NF-κB; Akt | Cytoskeletal Signaling; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling |
Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. Broussonin A c | |||
TN5369 |
Dehydroleucodine
Dehydroleucodin |
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Dehydroleucodine has antidiarrheal, anti-inflammatory, anti-microbial, embryotoxicity, gastric cytoprotective, anti-cancer activities. Dehydroleucodine has an important inhibitory effect in cellular pathways regulating adipocyte differentiation by modulat | |||
TN1862 | Licoflavonol | Antifection | Microbiology/Virology |
Licoflavonol is a novel natural inhibitor of Salmonella T3SS, could be a promising candidate for novel type of anti-virulence drugs, it exhibits a strong inhibitory effect on the secretion of the SPI-1 effector proteins via regulating the transcription of | |||
T73717 | cGAMP diammonium | ||
cGAMP (Cyclic GMP-AMPP) diammonium 是一种内源性第二信使,通过触发干扰素的产生来响应胞浆 DNA。它通过激活干扰素基因刺激因子(STING),启动信号级联,进而导致I型干扰素及其他免疫介质的生成。 | |||
TN3882 | Dodoviscin A | cAMP; Tyrosinase; transporter | GPCR/G Protein; Metabolism; Proteases/Proteasome |
Dodoviscin A may be a new promising pigmentation-altering agent for cosmetic and therapeutic applications, it can inhibit melanin biosynthesis induced by 3-isobutyl-1-methylxanthine and PD98059.Dodoviscin A can promote adipocyte differentiation as charact | |||
TN2775 |
2-Methoxystypandrone
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MMP; BCL; IκB/IKK; GSK-3; TNF; NOS; NF-κB; Wnt/beta-catenin; COX; JAK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells |
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitant | |||
T36563 |
(E)-Guggulsterone
|
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Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hy... | |||
T37911 |
cis-Resveratrol
顺式白藜芦醇,(Z)-Resveratrol |
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Resveratrol is a potent phenolic antioxidant found in grapes, red wine, and various berries that also has antiproliferative and anti-inflammatory activity. cis-Resveratrol is the double bond isomer of trans-resveratrol, the more often studied and naturally abundant of the two resveratrol isomers. cis-Resveratrol exhibits antioxidant activity in the µM range similar to that observed with trans-resveratrol. It blocks production of reactive oxygen species (ROS) by inhibition of NAD(P)H oxidase ... |