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Search Results for " viability "

176

抑制剂 & 化合物

44

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T16104	ML-9	Myosin; Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	ML-9 是 Akt 激酶的一种选择性强效抑制剂，可抑制肌球蛋白轻链激酶 (MLCK) 和基质相互作用分子1(STIM1) 活性。它通过刺激自噬小体的形成并抑制其降解来诱导自噬。它抑制 MLCK，PKA 和 PKC 活性，Ki 值分别为 4、32 和 54 μM。
T6878	LJI308	S6 Kinase	MAPK; PI3K/Akt/mTOR signaling
	LJI308 是泛RSK 抑制剂，对 RSK1、RSK2 和 RSK3 的IC50分别为 6、4 和 13 nM。它抑制辐照、EGF 处理和表达 KRAS 突变的细胞中 RSK (T359/S363) 和 YB-1 (S102) 的磷酸化。
T5104	BTSA1	Apoptosis; BCL	Apoptosis
	BTSA1 是一种有口服活性的 BAX 激活剂，IC50为 250 nM，EC50为 144 nM。它以高亲和力和特异性与 N 末端激活位点结合，并诱导 BAX 发生构象变化，从而导致BAX 介导的细胞凋亡。
T8308	NL-1	Mitochondrial Metabolism; Autophagy	Autophagy; Metabolism
	NL-1 是一种mitoNEET 抑制剂，具有抗白血病作用。它抑制 REH 和 REH/Ara-C 细胞生长，IC50分别为 47.35 µM 和 56.26 µM。
T9776	TRPM4 inhibitor 8	TRP/TRPV Channel	Membrane transporter/Ion channel
	TRPM4 inhibitor 8 是瞬态受体电位 melastatin 4 (TRPM4) 的抑制剂，它有助于活力、迁移、细胞周期转变和粘附。
T9662	SRI 37892	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	SRI 37892是一种 Fzd7抑制剂，对 Wnt/β-catenin 信号传导和癌症细胞活性具有强大的活性。
T16040	Mepazine 甲哌啶嗪,Pecazine	Apoptosis; MALT	Apoptosis; Immunology/Inflammation
	Mepazine (Pecazine) 是一种有效的特异性 MALT1 抑制剂。 Mepazine 抑制 GSTMALT1 全长和 GSTMALT1 325-760，IC50 为 0.83 μM 和 0.42 μM。 Mepazine 增强细胞凋亡并影响细胞活力。
T77660	TINK-IN-1	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	TINK-IN-1 是一种具有选择性和高效性的 TNIK 抑制剂(IC50：8 nM)。TINK-IN-1 抑制结直肠癌细胞活力，可用于研究智力发育障碍。
T11940	Malic enzyme inhibitor ME1 ME1	Others	Others
	Malic enzyme inhibitor ME1 (ME1) 是苹果酸酶的特异性抑制剂 (IC50 = 0.15 μM)。苹果酸酶抑制剂 ME1 降低细胞活力/代谢活性。
T12896L	Shepherdin 79-87 acetate Shepherdin 79-87 acetate (861224-28-4 free base)	HSP; Survivin	Apoptosis; Cytoskeletal Signaling; Metabolism
	Shepherdin 79-87 acetate 是 Hsp90 和 survivin 之间复合物的拟肽拮抗剂，survivin 是肿瘤细胞活力的另一个关键调节剂。
T9955	EX-A5758	NOS	Immunology/Inflammation
	EX-A5758是一种新型推定的小分子 nNOS-NOS1 AP 抑制剂，可抑制炎症性伤害感受和化疗引起的神经性疼痛，并与紫杉醇协同降低肿瘤细胞活力
T68051	Delequamine RS 15385-197	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Delequamine (RS 15385-197) 是一种有效的选择性 α2-肾上腺素受体拮抗剂。
T6682	STF-118804 STF 118804,STF118804	Apoptosis; NAMPT	Apoptosis; Metabolism
	STF-118804是一种烟酰胺磷酸核糖基转移酶 Nampt 高选择性抑制剂，降低大多数 B-ALL 细胞系的活力，IC50 <10 nM。
T14017	2-NBDG 2-(N-7-硝基-2,1,3-苯并恶二唑-4-氨基)-2-脱氧-D-葡萄糖	Others	Others
	2-NBDG 是一种荧光指示剂 (λex=467 nm，λem=542 nm)，是一种荧光 D-葡萄糖类似物，可用于监测活细胞中的葡萄糖吸收。
T27064	CP-312 CP312,Cardioprotectant 312	Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	CP-312 (Cardioprotectant 312)是一种抗氧化防御反应激活剂，它通过诱导血红素加氧酶-1发挥作用，通过诱导 HMOX1 表达来靶向抗氧化反应网络，从而保护 hiPSC-CM 的活力。CP-312 保护人 iPSC 衍生的心肌细胞免受氧化应激。
T7366	NGI-1 ML414	Virus Protease	Microbiology/Virology
	NGI-1 (ML414) 是一种可渗透细胞的寡糖转移酶 (OST) 抑制剂，直接靶向和阻断 OST 催化亚基 STT3A 和 STT3B 的功能，可有效降低病毒感染性而不影响细胞活力。
T28543	RK-9123016 RK9123016,RK 9123016	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	RK-9123016是一种SIRT2抑制剂。RK-9123016增加真核翻译起始因子5A（eIF5A）（SIRT2的生理底物）的乙酰化水平，降低人乳腺癌细胞的细胞活力，同时降低c-Myc 表达。
T5627	Methoxychlor	Others	Others
	Methoxychlor 是一种有机氯农药，被认为是一种内分泌干扰物，会影响不同细胞模型中的 Ca²⁺ 稳态和细胞活力。
T9949	NSC 370284	STAT	JAK/STAT signaling; Stem Cells
	NSC 370284 是一种小分子，可直接结合并抑制 STAT3/5，在体外和体内显着选择性地抑制具有高水平 TET1 表达的 AML 细胞的活力。
T6916	OICR-9429 OICR 9429	Histone Methyltransferase; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	OICR-9429 是一个新颖的相互作用的小分子Wdr5-MLL 拮抗剂，IC50是 5 uM，在体外抑制急性髓性白血病细胞。
T72968	ZINC00640089	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	ZINC00640089 是一种选择性的脂质运载蛋白-2 (LCN2) 抑制剂。ZINC00640089 对细胞增殖、细胞活力有抑制作用，可减少 SUM149 细胞的 AKT 磷酸化水平。ZINC00640089 可用于研究炎症性乳腺癌 (IBC) 。
T1937	Spautin-1 Spautin 1	Apoptosis; DUB; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	Spautin-1是一种特异性自噬抑制剂，可抑制泛素特异性肽酶 USP10和 USP13，IC50s 约为0.6到0.7 μM。
T5580	1-Naphthaleneacetic acid potassium salt α-萘醋酸钾,α-Naphthaleneacetic acid,Potassium alpha-naphthylacetate,Potassium 1-Naphthaleneacetate,1-NAA Potassium Salt	Phospholipase	Metabolism
	1-Naphthaleneacetic acid potassium salt (1-NAA Potassium Salt) 是一种合成的植物生长素，能够促进植物生长，也是一种PLA2抑制剂，IC50=13.16 μM。
T8850	sbp-7455	Autophagy	Autophagy
	SBP-7455 是一种高亲和力，可口服的双重ULK1/ULK2自噬抑制剂，可有效抑制ULK1/2酶活性，可研究三阴性乳腺癌，在 ADP-Glo 分析中的IC50分别为 13 nM 和 476 nM。
T22429	SR18662	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	SR18662 是 ML264 类似物，可抑制 Krüppel 样因子 5 (KLF5)，IC50 为 4.4 nM，降低多种结直肠癌细胞系的活力并诱导细胞凋亡。
T83653	SACLAC	Apoptosis; Caspase	Apoptosis; Proteases/Proteasome
	SACLAC 是一种半胱天冬酶活化抑制剂，具有抗肿瘤活性，可降低AML细胞活力，抑制AML细胞增殖，增加AML细胞死亡，并诱导AML细胞凋亡，可用于研究急性髓系白血病和癌症。
T18894	5(6)-CFDA CFDA,5-(6)-Carboxyfluorescein diacetate,5(6)-羧基荧光素二乙酸酯	Others	Others
	5(6)-CFDA (5-(6)-Carboxyfluorescein diacetate) 是具有细胞渗透性的胺反应型绿色荧光探针(λex: 492 nm; λem: 517 nm)，可用于细胞染色分析。
T8421	TED-347	YAP	Stem Cells
	TED-347 是不可逆的、共价的 YAP-TEAD 蛋白质-蛋白质相互作用变构抑制剂，对 TEAD4•Yap1 蛋白质-蛋白质相互作用的 EC50为 5.9 μM。它与 TEAD4 中央口袋内的 Cys-367 特异性共价结合(Ki:10.3 μM)。它可以抑制 TEAD 的转录活性，并且具有抗肿瘤作用。
T1642	Lenalidomide 来那度胺,CC-5013	Apoptosis; TNF; Ligand for E3 Ligase; Molecular Glues	Apoptosis; PROTAC
	Lenalidomide (CC-5013) 是 Thalidomide 的衍生物，也是具有口服活性免疫调节剂，以分子胶的方式作用。它是泛素 E3 连接酶 cereblon (CRBN) 的配体，可通过 CRBN-CRL4 泛素连接酶对两种淋巴转录因子 IKZF1 和 IKZF3 进行选择性泛素化和降解。
T22821	GSK J5 GSK-J5,GSKJ5	Histone Demethylase	Chromatin/Epigenetic
	GSK J5 对血吸虫和蠕虫具有抑制作用，常被当作一种吸血虫杀虫剂。GSK J5 以剂量和时间依赖的方式促进血吸虫死亡。GSK J5 可提高血吸虫死亡率、减低成虫活力。
T6911	NSC-87877 disodium NSC87877	Apoptosis; Phosphatase	Apoptosis; Metabolism
	NSC-87877 disodium (NSC87877) 是一种有效的Shp2和Shp1蛋白质酪氨酸磷酸酶抑制剂，IC50值分别为0.318 μM 和0.355 μM。NSC-87877还抑制双特异性磷酸酶26。
T2331	Solithromycin 索利霉素,OP-1068,CEM-101	Antibacterial; Antibiotic	Microbiology/Virology
	Solithromycin (OP-1068) 是口服可生物利用的抗菌剂，抑制肺炎链球菌、葡萄球菌、金黄色葡萄球菌和流感嗜血杆菌的细胞活力、蛋白质合成和生长速率， IC50 值分别为 7.5 ng/mL、40 ng/mL 和 125 ng/mL。它可与核糖体的大 50S 亚基结合抑制蛋白质生物合成。
T37518	Diphenyl disulfide Phenyl disulfide	Apoptosis; BCL; Endogenous Metabolite	Apoptosis; Metabolism
	Diphenyl disulfide (Phenyl disulfide) 在乳腺癌细胞系中显示出抗癌活性。Diphenyl disulfide 通过Bax 蛋白水解活化和伴随的自噬来诱导并增强乳腺癌细胞的凋亡。Diphenyl disulfide 以剂量依赖性方式抑制细胞增殖和活力，并减少集落形成。Diphenyl disulfide 可用来治疗乳腺癌。
T13983	0990CL	cAMP; Others	GPCR/G Protein; Others
	0990CL 是一种有效的异三聚体Gαi subunit 特异性抑制剂，可与纯化的Go±在gdp 结合状态下相互作用，能够阻断α2AR 介导的cAMP 调控。在细胞模型中低浓度0990CL 能够部分恢复cAMP 水平，高浓度的0990CL (10 μM)下，开始对细胞活力产生负面影响。
T28773	SI-2 SI2,EPH 116,EPH116,EPH-116	Others	Others
	SI-2是类固醇受体辅激活因子-3（SRC-3或 AIB1）的抑制剂（SMI）。SI-2可选择性降低细胞中 SRC-3的转录活性和蛋白浓度，并选择性诱导低纳摩尔范围（3-20 nM）内的乳腺癌症细胞死亡，但不影响正常细胞存活率。
T9105	NF-κB-IN-1 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-	IκB/IKK; NF-κB	NF-κB
	NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-)是一种 4-亚芳基姜黄素类似物，是抑制有效的NF-κB 信号通路抑制剂。它可有效抑制肺癌细胞的活力并减弱 A549 细胞的克隆活性。它可直接抑制IKK 来阻断 NF-κB 的激活。
T36493	CMLD-2	Apoptosis; HuR	Apoptosis; Chromatin/Epigenetic
	CMLD-2是一种 HuR-ARE 相互作用的抑制剂（Ki：350 nM），能竞争性地结合 HuR 蛋白并破坏其与富含腺嘌呤元素（ARE）的 mRNA 目标的相互作用。CMLD-2诱导细胞凋亡并通过 MAD2下调表现出抗肿瘤作用。CMLD-2 (1-75 μM ; 24-72 h) 对甲状腺癌细胞的活力具有抑制作用.CMLD-2 (20-30 μM ; 24-48 h) 激活 Caspases 并诱导H1299和A549细胞凋亡.CMLD-2 (30 μM ; 24-48 h) 诱导H1299和A549细胞的G1细胞周期停止和线粒体扰动。 CMLD-2（30μM；24-48小时）减少H1299细胞中HuR 和HuR 调节的mRNAs 和蛋白质的表达.CMLD-2（35μM；72小时）降低SW1736、8505C、BCPAP 和K1细胞的定向迁移能力。CMLD-2诱导SW1736、8505C、BCPAP 和K1细胞中的MAD2 mRNA 水平强烈下降。
T36141	Boscalid	Mitochondrial Metabolism	Metabolism
	Boscalid 是一种广谱羧酰胺类杀菌剂，通过与线粒体复合物 II/琥珀酸脱氢酶的泛醌位点结合来抑制真菌呼吸。
T34695	Spiclomazine HCl APY-606,Diceplon,Disepron,APY606,Spiclomazine Hydrochloride
	Spiclomazine HCl induced apoptosis in pancreatic cancer cells, which was generally related to cell viability, migration, and invasion.
T24423	LY5 LY 5,LY-5
	LY5 is an inhibitor of STAT3 that acts by inhibiting cell viability, cell migration, and angiogenesis in medulloblastoma cells.
T7650L	Resazurin Resazoin,Diazoresorcinol,Azoresorcin,Resazurine
	Resazurin is used as an oxidation-reduction indicator in cell viability.
T28138	NCDM-32B NCDM 32B,NCDM32B
	NCDM-32B, a novel potent and selective KDM4 inhibitor, impairs viability and transforms phenotypes of basal breast cancer.
T19771	SXT1596 NSC-65667,SXT-1596,NSC 65667,SXT 1596,NSC65667
	SXT1596 is a novel SS18-SSX/TLE1 interaction inhibitor. SXT1596 reduces cell viability and reactivates EGR1 expression in synovial sarcoma.
T68773	NSC-311068
	NSC-311068 is a novel selective inhibitor of TET1 transcription and 5-hydroxymethylcytosine (5hmC) modification, effectively inhibiting cell viability in AML with high expression of TET1.
T28079	MMV665852 MMV-665852,MMV 665852
	MMV665852, an antischistosomal agent, has been shown to inhibit worm viability in vitro and reduce worm burden in S. mansoni-infected mice.
T31696	EthD-1 EthD1,Ethidium Homodimer-1
	EthD-1 is a cell-impermeant viability indicator. It acts as a high-affinity nucleic acid stain.
T71413	U 26384
	U 26384 is a phospholipase A2 inhibitor reduces the severity of cell injury, but does not maintain cell viability in cultured human astroglial cell line UC-11MG during ATP depletion.
T40143	PROTAC CBP/P300 Degrader-1 PROTAC CBP/P300 Degrader-1
	PROTAC CBP/P300 Degrader-1 is an effective compound that degrades CBP/P300 in a potent manner. It significantly reduces cell viability in various cancer cell lines.
T33219	MB725 MB 725,MB-725
	MB725 is a strong and selective inducer of viability reduction in several cancer cell lines containing the oncogenic p53-Y220C mutation.
T71620	iBAP-II
	iBAP-II represses neuroendocrine lineage-specific ASCL1/MYCL/E2F signaling in SCLC cell lines, and dramatically inhibits SCLC cell viability and tumor growth in vivo.

化合物

Cat.No: T16104

Target: Myosin, Akt

Cat.No: T6878

Target: S6 Kinase

Cat.No: T5104

Target: Apoptosis, BCL

Cat.No: T8308

Target: Mitochondrial Metabolism, Autophagy

TRPM4 inhibitor 8

Cat.No: T9776

Target: TRP/TRPV Channel

Cat.No: T9662

Target: Wnt/beta-catenin

Cat.No: T16040

Synonym: 甲哌啶嗪,Pecazine

Target: Apoptosis, MALT

Cat.No: T77660

Target: Wnt/beta-catenin

Malic enzyme inhibitor ME1

Cat.No: T11940

Synonym: ME1

Target: Others

Shepherdin 79-87 acetate

Cat.No: T12896L

Synonym: Shepherdin 79-87 acetate (861224-28-4 free base)

Target: HSP, Survivin

Cat.No: T9955

Target: NOS

Cat.No: T68051

Synonym: RS 15385-197

Target: Adrenergic Receptor

Cat.No: T6682

Synonym: STF 118804,STF118804

Target: Apoptosis, NAMPT

Cat.No: T14017

Synonym: 2-(N-7-硝基-2,1,3-苯并恶二唑-4-氨基)-2-脱氧-D-葡萄糖

Target: Others

Cat.No: T27064

Synonym: CP312,Cardioprotectant 312

Target: Reactive Oxygen Species, Autophagy

Cat.No: T7366

Synonym: ML414

Target: Virus Protease

Cat.No: T28543

Synonym: RK9123016,RK 9123016

Target: Sirtuin

Cat.No: T5627

Target: Others

Cat.No: T9949

Target: STAT

Cat.No: T6916

Synonym: OICR 9429

Target: Histone Methyltransferase, JAK

Cat.No: T72968

Target: Akt

Cat.No: T1937

Synonym: Spautin 1

Target: Apoptosis, DUB, Autophagy

1-Naphthaleneacetic acid potassium salt

Cat.No: T5580

Synonym: α-萘醋酸钾,α-Naphthaleneacetic acid,Potassium alpha-naphthylacetate,Potassium 1-Naphthaleneacetate,1-NAA Potassium Salt

Target: Phospholipase

Cat.No: T8850

Target: Autophagy

Cat.No: T22429

Target: DNA/RNA Synthesis

Cat.No: T83653

Target: Apoptosis, Caspase

Cat.No: T18894

Synonym: CFDA,5-(6)-Carboxyfluorescein diacetate,5(6)-羧基荧光素二乙酸酯

Target: Others

Cat.No: T8421

Target: YAP

Cat.No: T1642

Synonym: 来那度胺,CC-5013

Target: Apoptosis, TNF, Ligand for E3 Ligase, Molecular Glues

Cat.No: T22821

Synonym: GSK-J5,GSKJ5

Target: Histone Demethylase

NSC-87877 disodium

Cat.No: T6911

Synonym: NSC87877

Target: Apoptosis, Phosphatase

Cat.No: T2331

Synonym: 索利霉素,OP-1068,CEM-101

Target: Antibacterial, Antibiotic

Diphenyl disulfide

Cat.No: T37518

Synonym: Phenyl disulfide

Target: Apoptosis, BCL, Endogenous Metabolite

Cat.No: T13983

Target: cAMP, Others

Cat.No: T28773

Synonym: SI2,EPH 116,EPH116,EPH-116

Target: Others

Cat.No: T9105

Synonym: 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-

Target: IκB/IKK, NF-κB

Cat.No: T36493

Target: Apoptosis, HuR

Cat.No: T36141

Target: Mitochondrial Metabolism

Spiclomazine HCl

Cat.No: T34695

Synonym: APY-606,Diceplon,Disepron,APY606,Spiclomazine Hydrochloride

Cat.No: T24423

Synonym: LY 5,LY-5

Cat.No: T7650L

Synonym: Resazoin,Diazoresorcinol,Azoresorcin,Resazurine

Cat.No: T28138

Synonym: NCDM 32B,NCDM32B

Cat.No: T19771

Synonym: NSC-65667,SXT-1596,NSC 65667,SXT 1596,NSC65667

Cat.No: T68773

Cat.No: T28079

Synonym: MMV-665852,MMV 665852

Cat.No: T31696

Synonym: EthD1,Ethidium Homodimer-1

Cat.No: T71413

PROTAC CBP/P300 Degrader-1

Cat.No: T40143

Synonym: PROTAC CBP/P300 Degrader-1

Cat.No: T33219

Synonym: MB 725,MB-725

Cat.No: T71620

Cat. No.	Product Name	Target	Signaling Pathways
T7982	3,6-Dihydroxyflavone	Others	Others
	3,6-Dihydroxyflavone 是一种抗癌剂。它能够提高细胞内氧化应激和脂质过氧化。它是能够根据剂量和时间依赖性地降低细胞活力，并活化半胱天冬酶级联、切割聚 (ADP-核糖) 聚合酶 (PARP) 诱导细胞凋亡。
TN1465	Cannabigerol	NOS; 5-HT Receptor; ROS	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Cannabigerol 是一种植物大麻素，是一种高亲和力 α2-肾上腺素能受体激动剂、中度亲和力 5-HT1A 受体拮抗剂和低亲和力 CB1/CB2受体拮抗剂。它可降低眼压，有潜力治疗青光眼。
TN3694	Coniferaldehyde	NOS; COX; Nrf2; PKC; Autophagy	Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Neuroscience
	Coniferaldehyde 能显着抑制酒球菌菌株的生长活力。 Coniferaldehyde 通过诱导血红素加氧酶 1 (HO-1) 发挥抗炎特性。
TN1425	Bacoside A3 苦艾素A3,白花猪母菜甙 A3	ATPase; ROS; P-gp	Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Bacoside A3 是一种天然的三萜皂苷，是Bacopa monnieri 的主要活性成分之一，显示出神经保护活性。
T2S1396	3-O-Acetyloleanolic acid 齐墩果酸3-乙酸酯,齐墩果酸 3-乙酸酯	Apoptosis	Apoptosis
	3-O-Acetyloleanolic acid 是从 Vigna sinensisK. 种子中提取得到的一种齐墩果醇酸，可诱导癌细胞凋亡并拥有抗血管生成作用。
T5S0636	Citric acid 柠檬酸,Citro,Citretten	Apoptosis; Others; Endogenous Metabolite; Antibacterial; Antibiotic	Apoptosis; Metabolism; Microbiology/Virology; Others
	Citric acid (Citro) 是柑橘类水果中发现的弱有机三羧酸。柠檬酸是食品添加剂和天然防腐剂。
T6S1780	Protosappanin B 原苏木素B,Q-100961,FT-0689654	Apoptosis	Apoptosis
	Protosappanin B (Q-100961) 是从苏木中提取的一种多酚类天然产物，具有抗肿瘤作用。它通过激活 MDM2 依赖性泛素化过程诱导 p53 蛋白降解。它显著提高细胞活力，抑制细胞凋亡并上调生长相关蛋白 43 的表达。
T3S1873	Talatisamine 塔拉乌头胺,塔拉萨敏	Potassium Channel	Membrane transporter/Ion channel
	Talatisamine 是一种乌头生物碱，对K+通道有特异性阻滞作用。它能减弱 beta- 淀粉样低聚物对培养的皮层神经元的毒性。
T4S0779	D-tetrahydropalmatine	Others; Dopamine Receptor	GPCR/G Protein; Neuroscience; Others
	D-Tetrahydropalmatine 是一种主要存在于延胡索类植物中的异喹啉生物碱。它是有机阳离子转运蛋白 1 抑制剂。它是多巴胺受体拮抗剂，对 D1 受体具有优先亲和力。
T2897	(Rac)-Shikonin (±)-Shikonin,Alkanet extract,Anchusin,紫草素,Anchusa acid	Others	Others
	(Rac)-Shikonin (Anchusin) 具有抗肿瘤作用。它能够诱导坏死死亡来绕过癌症耐药性。
TN1405	Arnicolide D 山金车内酯 D,山金车内酯D	Akt; Caspase; PI3K; STAT; mTOR	Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Arnicolide D 是从石胡荽中分离出的一种倍半萜内酯，以浓度和时间依赖性方式抑制鼻咽癌细胞活力。它调节细胞周期，激活 caspase 信号通路并抑制 PI3K/AKT/mTOR 和 STAT3 信号通路。
TN2496	1,4-Anthraquinone	Others	Others
	1,4-Anthraquinone 是一种抗癌药物，在体外与柔红霉素相同纳摩尔范围内阻断核苷转运、抑制大分子合成、诱导 DNA 片段化并降低 L1210 白血病细胞的生长和活力。它被提议为一种用于高效液相色谱 (HPLC) 测定药物制剂中 N-乙酰半胱氨酸 (NAC) 和卡托普利 (CAP) 的新型柱前试剂。
T36473	trans-Nerolidol
	trans-Nerolidol is a sesquiterpene that has been found in various plants, includingC. sativa, and has diverse biological activities, including antimicrobial, antioxidant, anticancer, and insecticidal properties.1,2,3,4In a disc assay,trans-nerolidol inhibits the growth ofS. aureus,B. subtilis,E. coli, andS. cerevisiaewith zones of inhibition measuring 10, 9, 10, and 4 mm, respectively.2It reduces viability of CaCo-2 adenocarcinoma cells with an IC50value of 28.7 mg/L and reduces production of re...
TWO2727	Propane-1,2,3-triyl tripalmitate Palmitic Triglyceride,Tripalmitin,Tripalmitoylglycerol,Glycerol Tripalmitate,三棕榈酸甘油酯	Others; Endogenous Metabolite	Metabolism; Others
	Propane-1,2,3-triyl tripalmitate (Glycerol Tripalmitate) 是内源性代谢产物的一种。
T6S1653	Albiflorin Alibiflorin,芍药内酯苷	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Albiflorin (Alibiflorin) 是一种牡丹根中的主要成分，是一种单萜糖苷。它具有神经保护、抗炎、抗氧化和缓解疼痛作用。
T40834	5-Hydroxymethyl-2'-deoxycytidine 5hmdC,2'-脱氧-5-(羟甲基)胞啶	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	5-Hydroxymethyl-2'-deoxycytidine 是 DNA 中 5-methyl-2'-deoxycytidine (5-mdC) 的氧化衍生物，引起DNA损伤反应，染色体畸变，复制叉损伤和细胞活力丧失。5-Hydroxymethyl-2’-deoxycytidine 复制叉不稳定性与染色质上聚（ADP-核糖）聚合酶1（PARP1）的存在有关。
T6S2391	L-Chicoric Acid (-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,L-菊苣酸,dicaffeoyltartaric acid,菊苣酸	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	L-Chicoric Acid (trans-Caffeoyltartaric acid) 是一种二咖啡酰酒石酸，是一种选择性可逆的 HIV-1 整合酶抑制剂，IC50约为 100 nM。它还可抑制 HIV-1 复制。
T2860	Vanillyl Alcohol 4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,香兰醇,Vanillin alcohol,Vanillic alcohol	Apoptosis; Others	Apoptosis; Others
	Vanillyl Alcohol (3-Methoxy-4-hydroxybenzyl alcohol) 是一种酚类醇，具有抗血管生成、抗惊厥、抗炎、抗氧化、神经保护和抗伤害活性。它由香兰素衍生而来，在食品和饮料中用作调味剂。
T4958	(-)-Alkannin Alkannin,左旋紫草素,紫草素,Shikonin	Apoptosis; PI3K	Apoptosis; PI3K/Akt/mTOR signaling
	(-)-Alkannin (Shikonin) 是从紫朱草中发现的一种天然产物，具有抗癌活性，可抑制细胞周期，诱导细胞凋亡，用作食品着色剂，在 Rho 激酶途径中可改善肝脏炎症。
T4S1615	Sanggenon C 桑根酮C,桑根酮 C,Sanggenone C	NF-κB	NF-κB
	Sanggenon C (Sanggenone C) 是一种从桑属的根皮中分离得到的黄烷酮 Diels-Alder 加合物化合物。它可抑制NF-κB 活性，抑制 RAW264.7 细胞中诱导型一氧化氮合酶的表达，以及肿瘤坏死因子-α 刺激的细胞粘附和血管细胞粘附分子-1 的表达。它具有抗氧化和抗炎作用，也有抑制胰脂肪酶作用。
T5S0053	Coptisine 黄连碱,Coptisin	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Coptisine (Coptisin) 是一种从黄连中分离到的生物碱，是非竞争性的IDO 抑制剂，Ki=为 5.8 μM，IC50=6.3 μM。
T3826	Polygalasaponin F 异牡荆苷,瓜子金皂苷己	NF-κB; TLR; Akt; PI3K	Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling
	Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷，可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌，能降低炎性细胞因子肿瘤坏死因子 α 的释放。
T0122	Bergenin Cuscutin,Bengenin,岩白菜素	Apoptosis; IL Receptor; Virus Protease; TNF; NF-κB; Antibacterial; NOD; Autophagy; Antifungal	Apoptosis; Autophagy; Immunology/Inflammation; Microbiology/Virology; NF-κB
	Bergenin (Bengenin) 是一种在许多药用植物中发现的多酚，有细胞保护和抗氧化作用。它还具有广泛的保肝、抗炎、抗肿瘤、抗病毒、抗真菌以及免疫调节作用。
TN1493	Chrysosplenol D 猫眼草酚D	IL Receptor; NF-κB; JNK	Immunology/Inflammation; MAPK; NF-κB
	Chrysosplenol D 属于甲氧基黄酮类化合物，可诱导 ERK1/2 介导的三阴性人乳腺癌细胞凋亡。它还显示出抗炎和中等抗锥虫活性。
TN1156	(-)-Curine	p53	Apoptosis
	(-)-Curine can inhibit viability of hepatocellular carcinoma cells in regardless of p53 status.
TN1407	Artocarpin 桂木黄素,2',4',5-三羟基-7-甲氧基-6-(3-甲基-1-丁烯基)-3-(3-甲基-2-丁烯基)黄酮	IL Receptor; TNF; COX	Apoptosis; Immunology/Inflammation; Neuroscience
	Artocarpin has anti- bactericidal effect, can reduce the viability of pneumococci by a factor of >1000, without obvious harm to lung epithelial cells.
TN1440	Beta-Hydroxyisovalerylshikonin	EGFR; Tyrosine Kinases; Prostaglandin Receptor; Src; AMPK; Fatty Acid Synthase	Angiogenesis; Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; Metabolism; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Beta-hydroxyisovalerylshikonin 是分离自Lithospermium radix 的天然产物，具有抑制PTK 的作用，对 EGFR 和 v-Src 受体作用的IC50分别为 0.7 μM 和 1 μM。它对多种肿瘤细胞系均有抑制作用，可以高效诱导 NCI-H522 和 DMS114 细胞的死亡。
T38495	Gypenoside LXXV
	Gypenoside LXXV, derived from Gynostemma pentaphyllum, is a deglycosylated form of ginsenoside Rb1. This compound effectively decreases cancer cell viability and exhibits potent anti-cancer properties.
T37444	Aranorosin
	Aranorosin is a fungal metabolite originally isolated from P. roseus. It has antimicrobial activity against B. subtilis, A. niger, and C. albicans when used at a concentration of 1 mg/ml. Aranorosin also reduces viability in apoptosis-resistant HeLa/Bcl-2 cells.
TN2501	1,5,6-Trihydroxy-3-methoxyxanthone 芒果	ROS	Immunology/Inflammation
	1,5,6-Trihydroxy-3-methoxyxanthone exhibits scavenging activity at 10 uM, it can reduce the viability of HL-60 cells significantly with IC50 values of 28.9 uM.
TN3737	Cycloartane-3,24,25-triol	ATPase	Membrane transporter/Ion channel
	Cycloartane-3,24,25-triol has potential for development as an anti-cancer agent against prostate cancer. It reduces the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively.
TN4699	Ohchinin	Others	Others
	Ohchinin exhibits potent inhibitory activities with 26 - 66% reduction of melanin content at 100 μm concentration with almost no or low toxicity to the B16 melanoma cells (70 - 99% cell viability at 100 μm).
TN3742	Cycloeucalenol	Others	Others
	Cycloeucalenol produces mild cardiotonic effects. Cycloeucalenol and its regio-isomer were present in a ratio of 1.04:1, a dose-dependent decrease in cell viability was observed.
T13922	Thevetiaflavone 2-Genistein-5-methyl ether,Apigenin-5-methyl ether	BCL; Caspase	Apoptosis; Proteases/Proteasome
	Thevetiaflavone (2-Genistein-5-methyl ether) 是一种来自 Wikstroemia indica 的天然类黄酮，可抑制乳酸脱氢酶从细胞质中泄漏并提高细胞活力。
T79982	2'-epi-2'-O-Acetylthevetin B GHSC-74	Apoptosis	Apoptosis
	2'-epi-2'-O-Acetylthevetin B (GHSC-74) 为源自Cerbera manghas L种子的强心苷，其抑制HepG2细胞增殖并诱导细胞凋亡(apoptosis)及线粒体膜电位降低。
T72735	Coleon-U-quinone
	Coleon-U-quinone 是一种有效的P-gp 抑制剂。Coleon-U-quinone 能抑制癌细胞活力，能提高多药耐药肿瘤细胞对Doxorubicin 的敏感性。
T72459	3-Oxo-hop-22(29)-ene
	3-Oxo-hop-22(29)-ene 是一种yeast α-glucosidase 抑制剂。3-Oxo-hop-22(29)-ene 具有中等的抗克氏锥虫和抗墨西哥利什曼原虫活性。3-Oxo-hop-22(29)-ene 具有微弱的抗炎活性。
TN1009	Epimagnolin B	NF-κB; NO Synthase; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; NF-κB
	Epimagnolin B 是一种双环氧木质素，分离自木兰中。它能够抑制 LPS 激活的小胶质细胞中 NO 的产生。它具有抗过敏以及抗炎作用。
T66078	Cardamonin
	Cardamonin, a chalcone extracted from cardamom spice with anti-inflammatory and anti-tumor activities. Cardamonin decreased viability of NPC(Nasopharyngeal carcinoma ) cells in a concentration-dependent manner. The IC50 values were 16.22 μM(CNE-1), 14.34 μM (CNE-2), 16.50 μM (HONE-1), and 68.12 μM (SUNE-1). Moreover, the expression level of the proapoptotic effector protein Bax and Bid was also markedly increased after treatment with cardamonin（15μM） in CNE-2 cells.In vivo, cardamonin (25 mg/kg ...
T35770	Cylindrospermopsin
	Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 &#181M, respectively), leading to cell death. [1] It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a Ki value of 10 &...
TN4592	Murrangatin	IL Receptor; TNF; COX; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line,
T35750	Trypacidin
	Trypacidin is a fungal metabolite originally isolated fromA. fumigatus.1It is active againstB. subtilisandM. bovis(MICs = 12.5 and 1.25 μg/ml, respectively), as well asT. cruziandT. gondii(MICs = 5-10 and 10-20 μg/ml, respectively).1,2It reduces viability and induces lysis of A549 human lung cancer cells (IC50s = 7.4 μM for both).3Trypacidin increases survival in a mouse model ofT. gondiiinfection when administered in six doses of 12.5 mg/kg each.1 1.Balan, J., Ebringer, L., Nemec, P., et al.Ant...
T37291	Lyso-Globotriaosylceramide (d18:1) Lyso-Globotriaosylceramide (d18:1)
	Lyso-globotriaosylceramide is a form of globotriaosylceramide that is lacking the fatty acyl group. It binds to Shiga toxin 1 (Stx1) in the presence of cholesterol and phosphatidylcholine but does not bind Stx2. It also reduces viability and aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate when used at concentrations of 50 and 1 μM, respectively. Lyso-globotriaosylceramide accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry diseas...
TN3323	Monomethyl lithospermate Lithospermic acid monomethyl ester	Akt; PI3K	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Monomethyl lithospermate (Lithospermic acid monomethyl ester) 具有潜在的抗病毒活性，通过激活PI5K/Akt信号传导，减轻体内大脑中动脉闭塞小鼠缺血性中风损伤，并在体外保护氧葡萄糖剥夺/复氧诱导的SHSY-3Y细胞。Monomethyl lithospermate 能提高 SHSY-5Y 细胞的生存能力，抑制线粒体膜电位 (MMOP) 崩溃，抑制细胞凋亡。Monomethyl lithospermate 还降低中动脉闭塞 (MCAO) 大鼠脑组织中的氧化应激水平，改善缺血性中风 (IS) 大鼠神经损伤。

天然产物

3,6-Dihydroxyflavone

Cat.No: T7982

Target: Others

Cat.No: TN1465

Target: NOS, 5-HT Receptor, ROS

Coniferaldehyde

Cat.No: TN3694

Target: NOS, COX, Nrf2, PKC, Autophagy

Cat.No: TN1425

Synonym: 苦艾素A3,白花猪母菜甙 A3

Target: ATPase, ROS, P-gp

3-O-Acetyloleanolic acid

Cat.No: T2S1396

Synonym: 齐墩果酸3-乙酸酯,齐墩果酸 3-乙酸酯

Target: Apoptosis

Cat.No: T5S0636

Synonym: 柠檬酸,Citro,Citretten

Target: Apoptosis, Others, Endogenous Metabolite, Antibacterial, Antibiotic

Protosappanin B

Cat.No: T6S1780

Synonym: 原苏木素B,Q-100961,FT-0689654

Target: Apoptosis

Cat.No: T3S1873

Synonym: 塔拉乌头胺,塔拉萨敏

Target: Potassium Channel

D-tetrahydropalmatine

Cat.No: T4S0779

Target: Others, Dopamine Receptor

Cat.No: T2897

Synonym: (±)-Shikonin,Alkanet extract,Anchusin,紫草素,Anchusa acid

Target: Others

Cat.No: TN1405

Synonym: 山金车内酯 D,山金车内酯D

Target: Akt, Caspase, PI3K, STAT, mTOR

1,4-Anthraquinone

Cat.No: TN2496

Target: Others

trans-Nerolidol

Cat.No: T36473

Propane-1,2,3-triyl tripalmitate

Cat.No: TWO2727

Synonym: Palmitic Triglyceride,Tripalmitin,Tripalmitoylglycerol,Glycerol Tripalmitate,三棕榈酸甘油酯

Target: Others, Endogenous Metabolite

Cat.No: T6S1653

Synonym: Alibiflorin,芍药内酯苷

Target: Reactive Oxygen Species

5-Hydroxymethyl-2'-deoxycytidine

Cat.No: T40834

Synonym: 5hmdC,2'-脱氧-5-(羟甲基)胞啶

Target: PARP

L-Chicoric Acid

Cat.No: T6S2391

Synonym: (-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,L-菊苣酸,dicaffeoyltartaric acid,菊苣酸

Target: Others, HIV Protease

Vanillyl Alcohol

Cat.No: T2860

Synonym: 4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,香兰醇,Vanillin alcohol,Vanillic alcohol

Target: Apoptosis, Others

Cat.No: T4958

Synonym: Alkannin,左旋紫草素,紫草素,Shikonin

Target: Apoptosis, PI3K

Cat.No: T4S1615

Synonym: 桑根酮C,桑根酮 C,Sanggenone C

Target: NF-κB

Cat.No: T5S0053

Synonym: 黄连碱,Coptisin

Target: Indoleamine 2,3-Dioxygenase (IDO)

Polygalasaponin F

Cat.No: T3826

Synonym: 异牡荆苷,瓜子金皂苷己

Target: NF-κB, TLR, Akt, PI3K

Cat.No: T0122

Synonym: Cuscutin,Bengenin,岩白菜素

Target: Apoptosis, IL Receptor, Virus Protease, TNF, NF-κB, Antibacterial, NOD, Autophagy, Antifungal

Chrysosplenol D

Cat.No: TN1493

Synonym: 猫眼草酚D

Target: IL Receptor, NF-κB, JNK

Cat.No: TN1156

Target: p53

Cat.No: TN1407

Synonym: 桂木黄素,2',4',5-三羟基-7-甲氧基-6-(3-甲基-1-丁烯基)-3-(3-甲基-2-丁烯基)黄酮

Target: IL Receptor, TNF, COX

Beta-Hydroxyisovalerylshikonin

Cat.No: TN1440

Target: EGFR, Tyrosine Kinases, Prostaglandin Receptor, Src, AMPK, Fatty Acid Synthase

Gypenoside LXXV

Cat.No: T38495

Cat.No: T37444

1,5,6-Trihydroxy-3-methoxyxanthone

Cat.No: TN2501

Synonym: 芒果

Target: ROS

Cycloartane-3,24,25-triol

Cat.No: TN3737

Target: ATPase

Cat.No: TN4699

Target: Others

Cat.No: TN3742

Target: Others

Thevetiaflavone

Cat.No: T13922

Synonym: 2-Genistein-5-methyl ether,Apigenin-5-methyl ether

Target: BCL, Caspase

2'-epi-2'-O-Acetylthevetin B

Cat.No: T79982

Synonym: GHSC-74

Target: Apoptosis

Coleon-U-quinone

Cat.No: T72735

3-Oxo-hop-22(29)-ene

Cat.No: T72459

Cat.No: TN1009

Target: NF-κB, NO Synthase, Prostaglandin Receptor

Cat.No: T66078

Cylindrospermopsin

Cat.No: T35770

Cat.No: TN4592

Target: IL Receptor, TNF, COX, Prostaglandin Receptor

Cat.No: T35750

Lyso-Globotriaosylceramide (d18:1)

Cat.No: T37291

Synonym: Lyso-Globotriaosylceramide (d18:1)

Monomethyl lithospermate

Cat.No: TN3323

Synonym: Lithospermic acid monomethyl ester

Target: Akt, PI3K

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