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841

抑制剂 & 化合物

39

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0802	Procaine hydrochloride Novocaine HCl,Procaine HCl,盐酸普鲁卡因	Histone Demethylase; 5-HT Receptor; DNA/RNA Synthesis; Sodium Channel; NMDAR; AChR	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Procaine hydrochloride (Novocaine HCl) 是DNA 脱甲基剂，是一种苯甲酸衍生物，具有局部麻醉和抗心律失常特性。
T0029	Procaine Duracaine,Spinocaine,普鲁卡因,Novocaine,Vitamin H3,奴夫卡因	Histone Demethylase; DNA/RNA Synthesis; Sodium Channel	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel
	Procaine (Vitamin H3) 是DNA 脱甲基剂，是一种酯类局部麻醉剂。它起效缓慢，作用持续时间短，主要用于浸润麻醉、周围神经阻滞和脊髓阻滞。
T19849L	2-PADQZ hydrochloride 2-PADQZ hydrochloride (60547-97-9 Free base)	Antiviral; Influenza Virus	Immunology/Inflammation; Microbiology/Virology
	2-PADQZ hydrochloride 显示出抗病毒活性并靶向甲型流感病毒 RNA 启动子。
T19241	Cloquintocet-mexyl	Others	Others
	Cloquintocet-mexyl, a herbicide, targets and controls coarse annual grasses within the Poaceae family.
T8635	CI 75300	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	CI 75300 靶向 P2X 嘌呤受体 7（人）。
T8598	CHEMBL241987 2-PHENYL-2,5-DIHYDRO-4H-PYRAZOLO[3,4-C]QUINOLIN-4-ONE	Adenosine Receptor	GPCR/G Protein; Neuroscience
	CHEMBL241987 靶向腺苷受体 A3（人）。
T37072	Nitroxynil 4-Hydroxy-3-iodo-5-nitrobenzonitrile,Trodax,Dovenix	Parasite	Microbiology/Virology
	Nitroxynil (4-Hydroxy-3-iodo-5-nitrobenzonitrile) is an anthelmintic compound that effectively targets parasites in both adult and immature stages. It is extensively employed in investigations pertaining to Fasciola hepatica infection.
T8584	6-Phenyldihydropyrimidine-2,4(1h,3h)-dione 2,4(1H,3H)-Pyrimidinedione,dihydro-6-phenyl-	Others	Others
	6-Phenyldihydropyrimidine-2,4(1h,3h)-dione 靶向多嘧啶束结合蛋白 1 亚型 a（人）。
T10232	Acetophenazine dimaleate	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Acetophenazine dimaleate 是抗精神病试剂，能够有效治疗焦虑抑郁。
T9884	EN523	Others	Others
	EN523 靶向 K48 泛素特异性去泛素酶 OTUB1 中的非催化变构半胱氨酸 C23。
T16925	SQ109 NSC 722041	Others; Parasite	Microbiology/Virology; Others
	SQ109 (NSC-722041) 是一种有效的锥鞭毛体形式的寄生虫抑制剂 (IC50 = 50 nM)。 SQ109 是一种抗结核药物，靶向 MmpL3。
T8603	ETHYL 2-AMINO-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	ETHYL 2-AMINO-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE 靶向前列腺素 E2受体 EP2亚型（人）。
T8912	5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE 5-乙基-4,5,6,7-四氢-噻唑并[5,4-C]吡啶-2-胺	PLK	Cell Cycle/Checkpoint
	5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE 靶向 PLK1。
T5173	SBI-0640756 SBI 0640756,SBI-756	PERK; Autophagy	Apoptosis; Autophagy
	SBI-0640756 (SBI-756) 是一种靶向 eIF4G1 并破坏 eIF4F 复合物的抑制剂。
T6094	MK-2461 MK2461	c-Met/HGFR	Tyrosine Kinase/Adaptors
	MK-2461 是 ATP 竞争性的 c-Met 抑制剂, 平均 IC50 值为 2.5 nM。
T9827	carfenazine	Dopamine Receptor	GPCR/G Protein; Neuroscience
	carfenazine 靶向多巴胺受体，用于精神分裂症研究。
T8913	1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID 1-(2,3-二氢-1,4-苯并二氧杂芑-6-基)-5-氧代吡咯烷-3-羧酸	GRK	GPCR/G Protein
	1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID 靶向 GRK2。
T8672	2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE BisOPP-A,双酚0PPA	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE 是针对促甲状腺激素受体（人）。
T8602	2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA6-BENZO[D]ISOTHIAZOL-3-ONE	Serine Protease	Proteases/Proteasome
	2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA6-BENZO[D]ISOTHIAZOL-3-ONE 靶向中性粒细胞弹性蛋白酶（人）。
T9061	EN4 EN4 MYC inhibitor	c-Myc	Cell Cycle/Checkpoint
	EN4 (EN4 MYC inhibitor) 是一种靶向 MYC 的半胱氨酸 171 (C171) 的共价配体。它抑制 MYC 转录活性，下调 MYC 靶标，并具有抗肿瘤作用。它对 c-MYC 的选择性高于 N-MYC 和 L-MYC。
T9751	Transfluthrin	Others	Others
	Transfluthrin 是一种挥发性拟除虫菊酯类杀虫剂，针对昆虫电压门控钠通道 (VGSC)。
TNU0436	2-Thiocytidine	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	2-Thiocytidine 是一种靶向惰性淋巴系统恶性肿瘤的嘌呤核苷类似物，具有广泛的抗肿瘤活性。2-Thiocytidine 通过抑制 DNA 合成诱导细胞凋亡 (apoptosis) 。
T15373	Gboxin	ATPase; Mitochondrial Metabolism	Membrane transporter/Ion channel; Metabolism
	Gboxin 是一种氧化磷酸化抑制剂，可靶向抑制胶质母细胞瘤生长，还抑制 F0F1 ATP 合成，具有抗肿瘤活性。
T33296	Merodantoin	Apoptosis	Apoptosis
	Merodantoin 是一种凋亡诱导剂，可引发与 ROS 依赖性自噬相关的细胞凋亡。 Merodantoin 靶向表达参与 Akt 依赖性 ROS 产生的 KRAS 突变的癌细胞。
T6562	Latrepirdine dihydrochloride Dimebolin dihydrochloride,Latrepirdine,Latrepirdine 2HCl,Dimebolin	Beta Amyloid; 5-HT Receptor; Adrenergic Receptor; GluR; Autophagy; Histamine Receptor	Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Latrepirdine dihydrochloride (Dimebolin dihydrochloride) 是一种具有口服活性和神经活性的多种药物靶点的拮抗剂，可刺激淀粉样前体蛋白分解代谢和 β-淀粉样蛋白分泌。
T0998	Diazinon 二嗪磷,Dimpylate,二嗪农	AChE; Parasite	Microbiology/Virology; Neuroscience
	Diazinon (Dimpylate) 是一种硫磷酸酯，是非内吸性有机磷杀虫剂，有效抑制，包括蟑螂、蠹虫、蚂蚁和跳蚤在内的多种害虫。
T35544	ML115	STAT	JAK/STAT signaling; Stem Cells
	ML115 是一种有效且选择性的转录 3 (STAT3) 激活剂，abn EC50 为 2.0 nM，对相关的 STAT1 和 NFκB 抗靶点无活性。
T7330	Nucleozin [4-(2-氯-4-硝基苯基)-1-哌嗪基](5-甲基-3-苯基-4-异噁唑基)-甲酮	Influenza Virus	Microbiology/Virology
	Nucleozin 靶向流感 A 核蛋白，这是一种病毒复制所必需的多功能 RNA 结合蛋白。
T9901	Adalimumab	TNF	Apoptosis
	Adalimumab 是人源的单克隆 IgG1 抗体，靶向肿瘤坏死因子α。
T41302	Itaconate-alkyne ITalk	Others	Others
	Itaconate-alkyne (ITalk) 是一种生物正交探针，用于对炎症性巨噬细胞中的衣康酸进行定量和位点特异性化学蛋白质组学分析，并能够对其直接靶标进行生化评估和蛋白质组学分析。
T22418	S-99	Others	Others
	S-99 是一种针对 ASK 的高纯度化学品，对免疫学、炎症、癌症研究非常重要。
T74140	β-D-Glucan	Others	Others
	β-D-Glucan 是一种靶向肿瘤相关巨噬细胞的化合物，具有抗肿瘤活性，可调节坏死性胰腺炎中的免疫反应
T6252	Ipatasertib GDC-0068,RG7440,帕他色替	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Ipatasertib (GDC-0068) 是选择性的，ATP 竞争性的pan-Akt 抑制剂，能够抑制Akt1 (IC50:5 nM)，Akt2 (IC50:18 nM)，Akt3 (IC50:8 nM)。
T8587	EcDsbB-IN-12 4,5-dichloro-2-[(2-chlorophenyl)methyl]pyridazin-3-one	Others	Others
	EcDsbB-IN-12 (4,5-dichloro-2-[(2-chlorophenyl)methyl]pyridazin-3-one) 靶向二硫键形成酶，是一种新型强效特异性EcDsbB 抑制剂。
T6342	NSC 23766 trihydrochloride Rac1 Inhibitor,NSC 23766	Apoptosis; Rho; Ras	Apoptosis; Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	NSC 23766 trihydrochloride (Rac1 Inhibitor) 是一种 Rac GTPase 抑制剂，靶向 GEF 对 Rac 的激活，IC50值约为 50 μM。
T5345	V-9302	Others	Others
	V-9302 是一种跨膜谷氨酰胺通量的竞争性拮抗剂。它选择性的靶向氨基酸转运体 ASCT2 (SLC1A5)，不影响 ASCT1。它能够阻碍 HEK-293 细胞中由 ASCT2 介导的谷氨酰胺摄取 (IC50=9.6 μM)。
T62620	ZY-444
	ZY-444是一种利用靶向丙酮酸羧化酶抑制乳腺癌进展的小分子。
T40811	Eflornithine RMI71782,α-difluoromethylornithine,DFMO,依氟乌氨酸,MDL71782
	Eflornithine is an irreversible inhibitor that specifically targets the enzyme ornithine decarboxylase. It serves as a therapeutic medication for two conditions: the treatment of African trypanosomiasis and the management of excessive facial hair growth in women.
T19206	β-Lactamase-IN-1 4-(1,3-dihydroxypropan-2-yl)-6-methoxypyrido[2,3-b]pyrazin-3-one,beta-lactamase-IN-1	Antibacterial	Microbiology/Virology
	β-Lactamase-IN-1 (4-(1,3-dihydroxypropan-2-yl)-6-methoxypyrido[2,3-b]pyrazin-3-one) 是一种 β-Lactamase 抑制剂，针对淋病奈瑟菌的感染。
T6824	EAI045	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EAI045是突变体EGFR 的变构抑制剂，在10 μM ATP 时抑制EGFR、EGFRL858R、EGFRT790M 和 EGFRL858R/T790M 的IC50值分别为1.9、0.019、0.19 和 0.002 μM。
T1801	SR9243	Liver X Receptor	Metabolism
	SR9243 是一种 liver-X-receptor 的反向激动剂，可诱导 LXR-辅阻遏物相互作用。
T16560	Poloxin	PLK	Cell Cycle/Checkpoint
	Poloxin 是一种 polo 样激酶 1 的 ATP 非竞争性抑制剂，靶向 polo-box 结构域，IC50值约为 4.8 μM。
T16128	MP-A08	S1P Receptor	GPCR/G Protein
	MP-A08 是高度选择性和 ATP 竞争性的 SPHK1 抑制剂。
T22254	Alflutinib AST2818,ASK120067	EGFR; P450	Angiogenesis; JAK/STAT signaling; Metabolism; Tyrosine Kinase/Adaptors
	Alflutinib (ASK120067) 是 EGFR 抑制剂。它对 T790M 的性耐药突变以及 EGFR 活性突变具有抑制作用。它对于癌症疾病，特别是非小细胞肺癌(NSC-LC)方面具有研究潜力。
T4665	Temsavir BMS626529	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Temsavir (BMS626529) 是一种新型附着抑制剂，靶向 HIV-1 gp120 并阻止其与 CD4+ T 细胞结合。
T5396	Letermovir AIC246,MK-8828,莱莫维韦	Others; HCV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Letermovir (AIC246) 是一种新型抗 CMV 抑制剂，靶向病毒末端酶，抑制其活性。
T4661	PKG drug G1	PKA	Tyrosine Kinase/Adaptors
	PKG drug G1 靶向作用于PKG Iα。它通过 C42 PKGIα 非依赖性机制，促进血管舒张以及血压降低。
TQ0064	Peretinoin NIK333	HCV Protease; Retinoid Receptor; S1P Receptor; Autophagy	Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Proteases/Proteasome
	Peretinoin (NIK333) 是口服非环状类视黄醇，靶向类视黄醇核受体，结构类维生素 A 。
T9230	KM 91104	ATPase	Membrane transporter/Ion channel
	KM 91104 是一种细胞通透性 V-ATPase 抑制剂，选择性作用于 V-ATPase 的 a3-b2 亚单位。
T1948	AZD4547	VEGFR; FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	AZD4547 是FGFR 家族抑制剂，能够作用于FGFR1 (IC50:0.2 nM)，FGFR2 (IC50:2.5 nM)，FGFR3 (IC50:1.8 nM) 和FGFR4 (IC50:165 nM)。

化合物

Procaine hydrochloride

Cat.No: T0802

Synonym: Novocaine HCl,Procaine HCl,盐酸普鲁卡因

Target: Histone Demethylase, 5-HT Receptor, DNA/RNA Synthesis, Sodium Channel, NMDAR, AChR

Cat.No: T0029

Synonym: Duracaine,Spinocaine,普鲁卡因,Novocaine,Vitamin H3,奴夫卡因

Target: Histone Demethylase, DNA/RNA Synthesis, Sodium Channel

2-PADQZ hydrochloride

Cat.No: T19849L

Synonym: 2-PADQZ hydrochloride (60547-97-9 Free base)

Target: Antiviral, Influenza Virus

Cloquintocet-mexyl

Cat.No: T19241

Target: Others

Cat.No: T8635

Target: P2X Receptor

Cat.No: T8598

Synonym: 2-PHENYL-2,5-DIHYDRO-4H-PYRAZOLO[3,4-C]QUINOLIN-4-ONE

Target: Adenosine Receptor

Cat.No: T37072

Synonym: 4-Hydroxy-3-iodo-5-nitrobenzonitrile,Trodax,Dovenix

Target: Parasite

6-Phenyldihydropyrimidine-2,4(1h,3h)-dione

Cat.No: T8584

Synonym: 2,4(1H,3H)-Pyrimidinedione,dihydro-6-phenyl-

Target: Others

Acetophenazine dimaleate

Cat.No: T10232

Target: Dopamine Receptor

Cat.No: T9884

Target: Others

Cat.No: T16925

Synonym: NSC 722041

Target: Others, Parasite

ETHYL 2-AMINO-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE

Cat.No: T8603

Target: Prostaglandin Receptor

5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE

Cat.No: T8912

Synonym: 5-乙基-4,5,6,7-四氢-噻唑并[5,4-C]吡啶-2-胺

Target: PLK

Cat.No: T5173

Synonym: SBI 0640756,SBI-756

Target: PERK, Autophagy

Cat.No: T6094

Synonym: MK2461

Target: c-Met/HGFR

Cat.No: T9827

Target: Dopamine Receptor

1-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID

Cat.No: T8913

Synonym: 1-(2,3-二氢-1,4-苯并二氧杂芑-6-基)-5-氧代吡咯烷-3-羧酸

Target: GRK

2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE

Cat.No: T8672

Synonym: BisOPP-A,双酚0PPA

Target: Thyroid hormone receptor(THR)

2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA*6*-BENZO[D]ISOTHIAZOL-3-ONE

Cat.No: T8602

Target: Serine Protease

Cat.No: T9061

Synonym: EN4 MYC inhibitor

Target: c-Myc

Cat.No: T9751

Target: Others

Cat.No: TNU0436

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Cat.No: T15373

Target: ATPase, Mitochondrial Metabolism

Cat.No: T33296

Target: Apoptosis

Latrepirdine dihydrochloride

Cat.No: T6562

Synonym: Dimebolin dihydrochloride,Latrepirdine,Latrepirdine 2HCl,Dimebolin

Target: Beta Amyloid, 5-HT Receptor, Adrenergic Receptor, GluR, Autophagy, Histamine Receptor

Cat.No: T0998

Synonym: 二嗪磷,Dimpylate,二嗪农

Target: AChE, Parasite

Cat.No: T35544

Target: STAT

Cat.No: T7330

Synonym: [4-(2-氯-4-硝基苯基)-1-哌嗪基](5-甲基-3-苯基-4-异噁唑基)-甲酮

Target: Influenza Virus

Cat.No: T9901

Target: TNF

Itaconate-alkyne

Cat.No: T41302

Synonym: ITalk

Target: Others

Cat.No: T22418

Target: Others

Cat.No: T74140

Target: Others

Cat.No: T6252

Synonym: GDC-0068,RG7440,帕他色替

Target: Akt

Cat.No: T8587

Synonym: 4,5-dichloro-2-[(2-chlorophenyl)methyl]pyridazin-3-one

Target: Others

NSC 23766 trihydrochloride

Cat.No: T6342

Synonym: Rac1 Inhibitor,NSC 23766

Target: Apoptosis, Rho, Ras

Cat.No: T5345

Target: Others

Cat.No: T62620

Cat.No: T40811

Synonym: RMI71782,α-difluoromethylornithine,DFMO,依氟乌氨酸,MDL71782

β-Lactamase-IN-1

Cat.No: T19206

Synonym: 4-(1,3-dihydroxypropan-2-yl)-6-methoxypyrido[2,3-b]pyrazin-3-one,beta-lactamase-IN-1

Target: Antibacterial

Cat.No: T6824

Target: EGFR

Cat.No: T1801

Target: Liver X Receptor

Cat.No: T16560

Target: PLK

Cat.No: T16128

Target: S1P Receptor

Cat.No: T22254

Synonym: AST2818,ASK120067

Target: EGFR, P450

Cat.No: T4665

Synonym: BMS626529

Target: HIV Protease

Cat.No: T5396

Synonym: AIC246,MK-8828,莱莫维韦

Target: Others, HCV Protease

Cat.No: T4661

Target: PKA

Cat.No: TQ0064

Synonym: NIK333

Target: HCV Protease, Retinoid Receptor, S1P Receptor, Autophagy

Cat.No: T9230

Target: ATPase

Cat.No: T1948

Target: VEGFR, FGFR

Cat. No.	Product Name	Target	Signaling Pathways
T8229	5,7,3',4'-Tetramethoxyflavone 木犀草素四甲醚,3,4,5,7-四甲氧基黄酮	Antibacterial; Parasite; Antifungal	Microbiology/Virology
	5,7,3',4'-Tetramethoxyflavone (TMF), a prominent polymethoxyflavone (PMF) derived from M. exotica, displays a range of notable bioactivities. These include anti-malarial, anti-fungal, anti-mycobacterial, and anti-inflammatory properties. Moreover, TMF specifically targets β-catenin signaling to exhibit chondroprotective activity.
T3021	Bulleyaconitine A 草乌甲素,Bulleyaconi cine A	Sodium Channel	Membrane transporter/Ion channel
	Bulleyaconitine A (Bulleyaconi cine A) 是一种分离自乌头属植物的抗炎活性化合物，也可用于缓解疼痛的研究。
T2831	Glycocholic acid Glycocholate,甘氨胆酸,cholylglycine	Others; Endogenous Metabolite	Metabolism; Others
	Glycocholic acid (Glycocholate) 是一种胆汁酸，具有抗肿瘤活性，能够靶向作用于耐药泵和非耐药泵通路。
T17048	Tetradecanoylcarnitine L-Myristoylcarnitine,Myristoyl-L-(-)-carnitine	Endogenous Metabolite	Metabolism
	Tetradecanoylcarnitine (L-Myristoylcarnitine) 是一种酰基肉碱，参与长链脂肪酸的β-氧化,是极长链酰辅酶A脱氢酶缺乏症的一种潜在标记物。
TN2373	(E/Z)-Ginkgolic acid C17:2 Ginkgolic Acid C17:2	Dehydrogenase	Metabolism
	(E/Z)-Ginkgolic acid C17:2 (Ginkgolic Acid C17:2) 是一种可从银杏中提取的天然产物，可靶向人二氢乳清酸脱氢酶 (DHODH).
TN1403	Arjunolic acid	IL Receptor; TNF; Reactive Oxygen Species; JNK; AChE	Apoptosis; Immunology/Inflammation; MAPK; Metabolism; Neuroscience; NF-κB
	Arjunolic acid 是分离自蓝莓的皂苷，具有抗氧化、抗菌和抗炎症等多种生物活性，在保护细胞和组织免受活性氧的有害作用中发挥重要作用。
T14046	Anandamide 花生四烯酸乙醇胺,(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide	Cannabinoid Receptor; Endogenous Metabolite	GPCR/G Protein; Metabolism
	Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide) 是一种免疫调节剂，通过大麻素受体 CB1 和 CB2 起作用，还通过中枢神经系统中的其他靶点起作用，如 GPR18/GPR55。
T1558	Resveratrol 白藜芦醇,trans-Resveratrol,SRT 501	Apoptosis; Mitophagy; IκB/IKK; Lipoxygenase; Sirtuin; COX; NADPH; DNA/RNA Synthesis; Nrf2; Antibacterial; Antibiotic; Autophagy; Antifungal	Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB
	Resveratrol (SRT 501) 属于多酚类天然产物，是一种植物抗毒素，具有抗氧化和化学预防活性。Resveratrol 的靶点广泛，包括 COX、SIRT、LOC 等。Resveratrol 可以诱导细胞自噬和凋亡。
T4808	Agmatine sulfate Agmatine sulfate salt,硫酸胍基丁胺	Endogenous Metabolite; NO Synthase; Imidazoline Receptor	Immunology/Inflammation; Metabolism; Neuroscience
	Agmatine sulfate (Agmatine sulfate salt) 是咪唑啉受体的内源性激动剂和一氧化氮合酶抑制剂。它靶向神经递质系统，离子通道和一氧化氮合成。
T14304	Aphidicolin	Others	Others
	Aphidicolin is a potent inhibitor of cellular deoxyribonucleic acid synthesis and inhibits the growth of herpes simplex virus[2]. Aphidicolin is an inhibitor of DNA polymerase α and δ, prevents mitotic cell division by interfering with the activity of DNA
TN1249	3-Epiursolic acid	Cysteine Protease; Immunology/Inflammation related	Immunology/Inflammation; Proteases/Proteasome
	3-Epiursolic Acid 是一种三萜类物质，分离自桃金娘科植物，是组织蛋白酶 L 的竞争性抑制剂（IC50=6.5 μM，Ki=19.5 μM），对 cathepsin B 无明显作用。
T6981	1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid 1-甲基-6-氧代-1,6-二氢吡啶-3-羧酸,Nudifloric Acid	Others	Others
	1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (Nudifloric Acid) 是来源于冬虫夏草，能够靶向阻断 AP-1 介导的荧光素酶活性，具有抗炎活性。其中冬虫夏草具有抗氧化，抗癌，抗炎，抗糖尿病，抗肥胖，抗血管生成和抗伤害感受活动。
TN1015	Meranzin	Adrenergic Receptor; Immunology/Inflammation related	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Meranzin 是从传统中药 Chaihu-Shugan-San (CSS) 中的生物活性化合物，是从紫茉莉叶中分离出的，能够调节共有的 α2-肾上腺素受体，并参与 AMPA-ERK1/2-BDNF 信号传导。它有潜在的预防动脉粥样硬化和抑郁症合并症。
TN1620	Eriocalyxin B 毛萼乙素	Apoptosis; cAMP; NF-κB; STAT	Apoptosis; GPCR/G Protein; JAK/STAT signaling; NF-κB; Stem Cells
	Eriocalyxin B 是从中草药枇杷素中分离得到的一种二萜类天然产物，可诱导细胞凋亡，具有抗癌和抗炎作用。
T4900	(±)-Methyl Jasmonate (±)-茉莉酸甲酯,甲基茉莉酮酸酯,(±)-Jasmonic Acid methyl ester,Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate	Others; Endogenous Metabolite	Metabolism; Others
	Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate ((±)-Jasmonic Acid methyl ester) 是内源性代谢产物的一种。
T2S1792	Lycobetaine 石蒜内胺,Ungeremine,石蒜醋胺,石蒜碱内铵盐	Antibacterial	Microbiology/Virology
	Lycobetaine (Ungeremine) 是一种潜在的抗罗克福尔青霉和黑曲霉的生物杀菌剂。它对柱状黄杆菌有很强的抗菌活性。它有效地靶向哺乳动物以及细菌I 型和II 型拓扑异构酶。它显示出强烈的乙酰胆碱酯酶抑制活性（IC(50) 值为 0.35 microM）。它具有抗原生动物活性，在体外试验中对Trypanosoma brucei rhodesiense、T. cruzi 表现出良好的活性。
T25664	Lepidiline A Macaline A	Others	Others
	Lepidiline A (Macaline A) 是一种具有抗炎症活性的黄酮木质素。Lepidiline A 对HL-60细胞具有细胞毒活性，IC50值为 32.3 μM。它是从芸苔科植物Lepidium meyenii Walpers 的活性成分，可改善小鼠内源性性激素的平衡，提高果蝇的繁殖力。Lepidiline A 靶向HSD17B1基因的机制来增强酶的活性，提高性激素的生物转化效率，提高生殖能力。Lepidiline A 具有抗癌活性。
T3729	Ethyl gallate Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯	MMP; NF-κB; Akt; Antibacterial	Cytoskeletal Signaling; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Ethyl gallate (gallic acid ethyl ester) 是一种非类黄酮酚过氧化氢清除剂。
T5S2343	Acetylshikonin 乙酰紫草素,Acetyl shikonin	Others; P450; AChE	Metabolism; Neuroscience; Others
	Acetylshikonin 来源于紫草根，具有抗癌、抗炎作用。它是一种 AChE 抑制剂，具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂，对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。
T40298	Phallacidin
	Phallacidin, a phallotoxin family member, targets and binds to F-actin in mushroom toxins.
T11274	Ferulenol	Others	Others
	Ferulenol, a sesquiterpene prenylated coumarin derivative, exhibits potent antimycobacterial activity and haemorrhagic action. This compound selectively targets succinate ubiquinone reductase within the ubiquinone cycle as its specific mode of inhibition.
T39918	(±)-Phrymarolin II
	(±)-Phrymarolin II is a promising new class of plant virus (tobacco mosaic virus) inhibitors.
T80779	WDB002
	WDB002，一种FK506/雷帕霉素家族的天然产物，靶向CEP250，可应用于COVID-19研究。
TN4860	Pueroside B	COX; PPAR	DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience
	Pueroside B may can treat coronary heart disease, it can interact with two or more targets[peroxisome proliferator activated receptor γ (PPAR-γ), angiotensin-converting enzyme (ACE), hydroxymethylglutaryl coenzyme A receptor (HMGR), cyclooxygenase-2 (COX2
TN2360	Falcarinol Falcarinol,Panaxynol,人参炔醇	HSP	Cytoskeletal Signaling; Metabolism
	Falcarinol, also known as Panaxynol, is a naturally occurring compound that acts as an orally active inhibitor of Hsp90. It effectively targets both the N-terminal and C-terminal regions of Hsp90, displaying high selectivity with minimal toxicities. Furthermore, Falcarinol (Panaxynol) demonstrates the ability to induce apoptosis.
TN1550	Danshenxinkun A 丹参新醌甲,丹参新醌A	Others	Others
	Danshenxinkun A, Danshenxinkun B and Neocryptotanshinone may intervene thrombotic diseases by adjusting the targets mainly involved in pathways of endocrine system, signal transduction, signaling molecules and interaction, cell motility, environmental ada
T38441	Manzamine A hydrochloride
	Manzamine A hydrochloride is an orally active beta-carboline alkaloid that exhibits specific inhibitory effects on GSK-3β (IC50 = 10.2 μM) and CDK-5 (IC50 = 1.5 μM). Additionally, it targets vacuolar ATPases, leading to the inhibition of autophagy in pancreatic cancer cells. Manzamine A hydrochloride possesses antimalarial and anticancer properties, and also demonstrates potent activity against HSV-1[4].
T75489	Mildiomycin
	Mildiomycin是一种针对大麦白粉病具有活性的链轮丝菌抗生素。该化合物能够抑制部分分枝杆菌和红桃菌的生长，然而，对大部分真菌和细菌则显示出无效性。
T82326	Genkwadaphnin
	Genkwadaphnin是一种瑞香烷二萜，能够靶向内输蛋白importin-β1，减少CRPC核心驱动因子在细胞核内的积累，并关闭其下游致癌信号通路。此外，Genkwadaphnin在小鼠体内显现出能显著抑制去势抵抗性前列腺癌(CRPC)发展的抗癌活性。
T75491	3-(2-Hydroxyethyl) thio withaferin A
	3-(2-Hydroxyethyl) thio withaferin A 为Withaferin A衍生物，后者为甾体内酯，能够抑制NF-kB活性并靶向波形蛋白(vimentin)，展现出抗炎及抗肿瘤效果。此外，Withaferin A亦为内皮蛋白C受体(EPCR)脱落的抑制剂。
T75686	Enfumafungin
	Enfumafungin，一种从Hormonema carpetanum菌提取的三萜糖苷，具有抗真菌特性，主要通过作为(1,3)-beta-D-葡聚糖合酶抑制剂影响真菌细胞壁发挥作用。其对酵母和多数真菌（除隐球菌外）有效，但不会抑制枯草芽孢杆菌的生长。
T75333	Quinine hemisulfate hydrate
	Quinine hemisulfate hydrate，一种从金鸡纳树皮提取的生物碱，具有抗疟疾效果。作为钾离子通道 (potassium channel) 抑制剂，它能够抑制由电压脉冲触发的MT mSlo3 (KCa5.1) 通道在+100 mV下的电流活动，其IC50值达169 μM。
T73072	PTP1B-IN-20
	PTP1B-IN-20 是蛋白酪氨酸磷酸酶 1B (PTP1B) 的选择性抑制剂 (IC50=1.05 μM)，抑制力超出高度同源 T 细胞蛋白酪氨酸磷酸酶 (TCPTP；IC50=78.0 μM)，PTP1B 是抑制 2 型糖尿病的重要靶点。
TN5369	Dehydroleucodine Dehydroleucodin
	Dehydroleucodine has antidiarrheal, anti-inflammatory, anti-microbial, embryotoxicity, gastric cytoprotective, anti-cancer activities. Dehydroleucodine has an important inhibitory effect in cellular pathways regulating adipocyte differentiation by modulat
T73206	Wikstrol A
	Wikstrol A 是一种有效的抗真菌剂、抗有丝分裂剂和抗HIV-1剂。Wikstrol A 诱导稻瘟病菌菌丝体的形态变形，MMDC 值为 70.1 µM。Wikstrol 对微管聚合具有活性，IC50值为 131 µM。Wikstrol A 显示抗HIV-1活性，IC50值为 67.8 µM。
T35770	Cylindrospermopsin
	Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 &#181M, respectively), leading to cell death. [1] It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a Ki value of 10 &...
TN4286	Isodunnianol	NOS; NF-κB; ROS; AChR	Immunology/Inflammation; Neuroscience; NF-κB
	Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from 0.1 to 10 uM in the primary cultured rat cortical neurons. Isodunnianol, dunnianol, and Macrant
T75540	Ipomoeassin F
	Ipomoeassin F 是一种高效且具有选择性的内质网(ER)蛋白转位抑制剂，它通过作用于ER膜上的Sec61复合物（Sec61α）的成孔亚基来实现其功能。此化合物能特异性抑制SARS-CoV-2蛋白在ER膜上的转位，同时阻碍分泌蛋白和I型跨膜蛋白（TMP）的ER转运，但对III型TMP的转运不产生影响。
T36563	(E)-Guggulsterone
	Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hy...

天然产物

5,7,3',4'-Tetramethoxyflavone

Cat.No: T8229

Synonym: 木犀草素四甲醚,3,4,5,7-四甲氧基黄酮

Target: Antibacterial, Parasite, Antifungal

Bulleyaconitine A

Cat.No: T3021

Synonym: 草乌甲素,Bulleyaconi cine A

Target: Sodium Channel

Glycocholic acid

Cat.No: T2831

Synonym: Glycocholate,甘氨胆酸,cholylglycine

Target: Others, Endogenous Metabolite

Tetradecanoylcarnitine

Cat.No: T17048

Synonym: L-Myristoylcarnitine,Myristoyl-L-(-)-carnitine

Target: Endogenous Metabolite

(E/Z)-Ginkgolic acid C17:2

Cat.No: TN2373

Synonym: Ginkgolic Acid C17:2

Target: Dehydrogenase

Cat.No: TN1403

Target: IL Receptor, TNF, Reactive Oxygen Species, JNK, AChE

Cat.No: T14046

Synonym: 花生四烯酸乙醇胺,(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide

Target: Cannabinoid Receptor, Endogenous Metabolite

Cat.No: T1558

Synonym: 白藜芦醇,trans-Resveratrol,SRT 501

Target: Apoptosis, Mitophagy, IκB/IKK, Lipoxygenase, Sirtuin, COX, NADPH, DNA/RNA Synthesis, Nrf2, Antibacterial, Antibiotic, Autophagy, Antifungal

Agmatine sulfate

Cat.No: T4808

Synonym: Agmatine sulfate salt,硫酸胍基丁胺

Target: Endogenous Metabolite, NO Synthase, Imidazoline Receptor

Cat.No: T14304

Target: Others

3-Epiursolic acid

Cat.No: TN1249

Target: Cysteine Protease, Immunology/Inflammation related

1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

Cat.No: T6981

Synonym: 1-甲基-6-氧代-1,6-二氢吡啶-3-羧酸,Nudifloric Acid

Target: Others

Cat.No: TN1015

Target: Adrenergic Receptor, Immunology/Inflammation related

Cat.No: TN1620

Synonym: 毛萼乙素

Target: Apoptosis, cAMP, NF-κB, STAT

(±)-Methyl Jasmonate

Cat.No: T4900

Synonym: (±)-茉莉酸甲酯,甲基茉莉酮酸酯,(±)-Jasmonic Acid methyl ester,Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate

Target: Others, Endogenous Metabolite

Cat.No: T2S1792

Synonym: 石蒜内胺,Ungeremine,石蒜醋胺,石蒜碱内铵盐

Target: Antibacterial

Cat.No: T25664

Synonym: Macaline A

Target: Others

Cat.No: T3729

Synonym: Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯

Target: MMP, NF-κB, Akt, Antibacterial

Cat.No: T5S2343

Synonym: 乙酰紫草素,Acetyl shikonin

Target: Others, P450, AChE

Cat.No: T40298

Cat.No: T11274

Target: Others

(±)-Phrymarolin II

Cat.No: T39918

Cat.No: T80779

Cat.No: TN4860

Target: COX, PPAR

Cat.No: TN2360

Synonym: Falcarinol,Panaxynol,人参炔醇

Target: HSP

Danshenxinkun A

Cat.No: TN1550

Synonym: 丹参新醌甲,丹参新醌A

Target: Others

Manzamine A hydrochloride

Cat.No: T38441

Cat.No: T75489

Cat.No: T82326

3-(2-Hydroxyethyl) thio withaferin A

Cat.No: T75491

Cat.No: T75686

Quinine hemisulfate hydrate

Cat.No: T75333

Cat.No: T73072

Dehydroleucodine

Cat.No: TN5369

Synonym: Dehydroleucodin

Cat.No: T73206

Cylindrospermopsin

Cat.No: T35770

Cat.No: TN4286

Target: NOS, NF-κB, ROS, AChR

Cat.No: T75540

(E)-Guggulsterone

Cat.No: T36563

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