Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ferulenol, a sesquiterpene prenylated coumarin derivative, exhibits potent antimycobacterial activity and haemorrhagic action. This compound selectively targets succinate ubiquinone reductase within the ubiquinone cycle as its specific mode of inhibition.
产品描述 | Ferulenol, a sesquiterpene prenylated coumarin derivative, exhibits potent antimycobacterial activity and haemorrhagic action. This compound selectively targets succinate ubiquinone reductase within the ubiquinone cycle as its specific mode of inhibition. |
体外活性 | At low concentrations, ferulenol inhibited ATP synthesis by inhibition of the adenine nucleotide translocase without limitation of mitochondrial respiration.?At higher concentrations, ferulenol inhibited oxygen consumption.?Ferulenol caused specific inhibition of succinate ubiquinone reductase without altering succinate dehydrogenase activity of the complex II.?Ferulenol inhibits succinate ubiquinone reductase(SQR) activity in a concentration-dependent manner and is as effective as thenoyltrifluoroacetone (TTFA).Ferulenol inhibits the oxidative phosphorylation process by interacting with adenine nucleotide translocase (ANT) and the complex II of the respiratory chain. |
分子量 | 366.49 |
分子式 | C24H30O3 |
CAS No. | 6805-34-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ferulenol 6805-34-1 Others Inhibitor inhibitor inhibit