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809

抑制剂 & 化合物

37

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4661	PKG drug G1	PKA	Tyrosine Kinase/Adaptors
	PKG drug G1 靶向作用于PKG Iα。它通过 C42 PKGIα 非依赖性机制，促进血管舒张以及血压降低。
T35520	Aflatoxin G1-13C17 Aflatoxin G1-13C17
	Aflatoxin G1-13C17is intended for use as an internal standard for the quantification of aflatoxin G1by GC- or LC-MS. Aflatoxin G1is a mycotoxin that has been found inA. terricola.1In vivo, aflatoxin G1is lethal to ducklings (LD50= 1.18 mg/kg).2It induces hepatocellular carcinoma tumor formation and lethality in rats when administered at doses of 1.4 and 3 mg/animal, respectively. Aflatoxin G1also inhibits liver and kidney succinate dehydrogenase and fumarase, as well as kidney cytochrome oxidase...
TP2427	Cucumarioside G1
	Cucumarioside G1 is a triterpene glycoside of holothurian from Cucumaria fraudatrix.
T29690	Aflatoxin G1 9,10-epoxide
	Aflatoxin G1 9,10-epoxide is a biochemical.
T15364	G-1	Estrogen Receptor/ERR; GPR	Endocrinology/Hormones; GPCR/G Protein
	G-1 是一种高亲和力的、非甾体的、有选择性的 GPR30激动剂(Ki:11 nM)。
T126188	Ajugamarin G1
	Ajugamarin G1 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T126188。
T126090	Hemsloside G1
	Hemsloside G1 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126090，CAS号为 129385-80-4。
T126031	Gypsophilasaponin G1
	Gypsophilasaponin G1 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126031，CAS号为 133632-77-6。
T25199	Cafaminol Cafaminolum,G1,G-1,G 1
	Cafaminol (methylcoffanolamine) is a vasoconstrictor and anticatarrhal of the methylxanthine family related to caffeine which is used as a nasal decongestant.
T36862	Ganglioside GT1b Mixture (sodium salt) Ganglioside GT1b Mixture (sodium salt),Ganglioside G1 Mixture
	Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. It binds to the neurotoxins botulinum toxin serotype A (BTxA), BTxA heavy chain, and tetanus toxin with IC50 values of 11, 0.74, and 7.2 μM, respectively.[1] Ganglioside GT1b-containing liposomes bind to the major coat protein VP1 from Merkel cell polyomavirus (MCPyV), which has been identified in Merkel cell carcinomas, identifying ganglioside GT1b as a putative MCP...
T66450	t-BuXPhos Pd G1
	[2-[2-(Amino-κN)ethyl]phenyl-κC][bis(1,1-dimethylethyl)[2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine]chloropalladium 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T66450。
T64659	RuPhos Pd G1
	Chloro(2-dicyclohexylphosphino-2',6'-di-i-propoxy-1,1'-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64659。
T7969	Dipyrithione	Others	Others
	Dipyrithione 似乎具有新的细胞毒性和强大的广谱抗肿瘤活性。
T7057	Methylstat	Histone Demethylase; Others	Chromatin/Epigenetic; Others
	Methylstat 是一种含有 Jumonji C 结构域的组蛋白去甲基化酶 (JMJD) 抑制剂的甲酯前药，具有良好的细胞渗透性。在体外试验中，methylstat 的游离酸可抑制 JMJD2A、JMJD2C、JMJD2E、PHF8 和 JMJD3，IC50 值分别约为 4.3、3.4、5.9、10 和 43 µM。 Methylstat 抑制 JMJD2C 敏感的食管癌细胞系 KYSE150 的生长，GI50 为 5.1 µM，而 methylstat 的游离酸在高达 100 µM 时不抑制细胞生长。 Methylstat 以浓度依赖性方式在多个位点诱导组蛋白高甲基化（KYSE150 细胞中 H3K4me3 和 H3K9me3 的 EC50 = 10.3 和 8.6 µM，MCF-7 细胞中的 EC50 分别为 6.7 和 6.3 µM）。
T7791	Iberdomide CC-220	Apoptosis; Ligand for E3 Ligase	Apoptosis; PROTAC
	Iberdomide (CC-220) 是一种口服有效的 cereblon E3 连接酶调节剂，对 cereblon 结合亲和力的 IC50约为150 nM。它是沙利度胺的衍生物，具有抗肿瘤和免疫刺激活性。
T1862	PR-619 PR 619,2,6-Diamino-3,5-dithiocyanopyridine	Apoptosis; DUB; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) 是一种 DUB 抑制剂，可诱导内质网应激和内质网应激相关的凋亡，对 USP4、USP8、USP7、USP2和 USP5的 EC50分别为 3.93、4.9、6.86、7.2 和 8.61 μM。
T8616	Fasentin N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide	transporter	Metabolism
	Fasentin (N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide) 是葡萄糖摄取抑制剂，可抑制GLUT-1/GLUT-4转运蛋白，优先抑制 GLUT4，IC50为 68 μM。它是死亡受体刺激敏化剂，可敏化细胞对 FAS 诱导的细胞死亡，具有抗血管生成活性。
T64624	RuPhos Pd G1 Methyl t-Butyl Ether Adduct
	Chloro(2-dicyclohexylphosphino-2',6'-diisopropoxy-1,1-biphenyl)[2-(2-aminoethylphenyl)]palladium(II) 2-methoxy-2-methylpropane complex 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T64624。
T24754	Hh-Ag1.5 SAG-1.5,SAG1.5,SAG 1.5	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	Hh-Ag1.5 (SAG-1.5) 是一种高效的 Hedgehog (Hh) 激动剂(EC50： 1 nM)和Smoothened (Smo)受体激动剂，对Smo的 EC50 为 1 nM、 Ki值在 0.5 和 2.3 nM 之间。Hh-Ag1.5 介导的重编程打破了非损伤肝脏干细胞的静止状态，从而挽救了肝衰竭。Hh-Ag1.5 诱导 hiPSCs 分化为皮肤前体细胞、脊髓运动神经元和脊髓感觉神经元。
T17483	Azido-PEG11-azide 叠氮-十一聚乙二醇-叠氮	Others; PROTAC Linker	Others; PROTAC
	Azido-PEG11-azide 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。
T7389	G15	Estrogen Receptor/ERR	Endocrinology/Hormones
	G15 是一种高亲和力的、选择性的 G 蛋白偶联雌激素受体(GPER/GPR30)拮抗剂(Ki:20 nM)。
T2038	RG108 N-Phthalyl-L-tryptophan	DNA Methyltransferase	Chromatin/Epigenetic
	RG108 (N-Phthalyl-L-tryptophan) 是一种非核苷的 DNA 甲基转移酶 (DNMTs) 抑制剂，IC50为115 nM。它阻断 DNA 甲基转移酶的活性位点，可引起抑癌基因的去甲基化和再激活。
T13238	Tyrphostin AG1433 SU1433,AG1433	VEGFR; PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Tyrphostin AG1433 (AG1433) 是选择性的PDGFRβ和VEGFR-2 (Flk-1/KDR)抑制剂，IC50分别为 5.0 μM 和 9.3 μM。Tyrphostin AG1433有防止血管形成的活性。
T18566	Propargyl-PEG12-bromide	Others; PROTAC Linker	Others; PROTAC
	Propargyl-PEG12-bromide 是 PEG 类PROTAC linker，可用于合成 PROTAC 分子。
T18031	Hydroxy-PEG10-acid HO-PEG10-CH2CH2COOH	Others; PROTAC Linker	Others; PROTAC
	Hydroxy-PEG10-acid (HO-PEG10-CH2CH2COOH) 是 PEG 类 PROTAC linker。可用于合成 PROTAC 分子。
T10616	BRM/BRG1 ATP Inhibitor-1	Epigenetic Reader Domain	Chromatin/Epigenetic
	BRM/BRG1 ATP Inhibitor-1 是变构双 Brahma 同源物 (BRM)/SWI/SNF 相关的基质相关肌动蛋白依赖性调节剂，染色质亚家族 A 成员 2 和 BRG1/SMARCA4 ATP 酶活性抑制剂，IC50值低于 0.005 μM。
T18267	Mal-PEG1-Val-Cit-OH	Others	Others
	Mal-PEG1-Val-Cit-OH是一种在抗体药物偶联体(ADCs)[1]合成中使用的可裂解单元聚乙二醇(PEG)连接器。
T3065	TG101209	Apoptosis; FLT; c-RET; JAK; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	TG101209 是一种选择性有效的 JAK2抑制剂，IC50值为 6 nM。它能抑制 Flt3和RET 的活性，IC50值分别为 25 nM 和 17 nM。
T7083	GLPG1837 ABBV-974	CFTR; Autophagy	Autophagy; Membrane transporter/Ion channel
	GLPG1837 (ABBV-974) 是一种有效的 CFTR 增强剂，对其 F508del 和 G551D 的 EC50 分别为 3 nM 和 339 nM。
T8780	AMG131 INT-131,AMG-131,CHS 131	PPAR	DNA Damage/DNA Repair; Metabolism
	AMG131 (CHS 131) 是一种新型非噻唑烷二酮(TZD) 选择性过氧化物酶体增殖物激活受体 (PPAR) γ 调节剂，可用于治疗 2 型糖尿病。
T17920	(S,R,S)-AHPC-PEG1-N3 VHL Ligand-Linker Conjugates 9,VH032-PEG1-N3,E3 ligase Ligand-Linker Conjugates 3	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC-PEG1-N3 (E3 ligase Ligand-Linker Conjugates 3) 是 E3 连接酶配体和linker 连接得到的偶联物，包含基于 (S,R,S)-AHPC 的 VHL 配体和 1 个单元 PEG linker。
T17719	Cbz-NH-PEG12-C2-acid	Others; PROTAC Linker	Others; PROTAC
	Cbz-NH-PEG12-C2-acid 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。
T11411	GLPG1205	GPR; Others	Endocrinology/Hormones; GPCR/G Protein; Others
	GLPG1205是一种有效的、具有口服活性的 GPR84（G 蛋白偶联受体）拮抗剂，具有抗炎活性。GLPG1205显示出良好的PK/PD 特征，可用于研究肺纤维化。
T17666	Boc-NH-PEG11-OH 叔丁氧羰基十一聚乙二醇羟基	Others; PROTAC Linker	Others; PROTAC
	Boc-NH-PEG11-OH 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。
T17561	Biotin-PEG12-NHS ester 生物素十二聚乙二醇琥珀酰亚胺酯	Others; PROTAC Linker	Others; PROTAC
	Biotin-PEG12-NHS ester 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。
T17464	Azide-PEG12-alcohol	Others; PROTAC Linker	Others; PROTAC
	Azide-PEG12-alcohol 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。
T17405	Amino-PEG12-acid	Others; PROTAC Linker	Others; PROTAC
	Amino-PEG12-acid 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。
T18125	m-PEG11-Br 甲基-十一乙二醇-溴代	Others; PROTAC Linker	Others; PROTAC
	m-PEG11-Br 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。
T18132	m-PEG12-acid 十一乙二醇单甲醚丙酸	Others; PROTAC Linker	Others; PROTAC
	m-PEG12-acid 是一种属于 PEG 类的 PROTAC linker，可用于 PROTAC 分子的合成。
T9961	L82-G17	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	L82-G17 是人体细胞中的一种非竞争性 LigI 选择性抑制剂，可用作 LigI 的催化活性和细胞功能的探针。
T60032	BRM/BRG1 ATP Inhibitor-2	Epigenetic Reader Domain	Chromatin/Epigenetic
	BRM/BRG1 ATP Inhibitor-2 是 BRG1/BRM ATPase 的抑制剂，可用于治疗 BAF 相关疾病的研究。
T18568	Propargyl-PEG11-methane	Others; PROTAC Linker	Others; PROTAC
	Propargyl-PEG11-methane 是 PEG 类 PROTAC linker。可用于合成 PROTAC 分子。
T78525	IRG1-IN-1	Others	Others
	IRG1-IN-1为衣康酸衍生物，具有抑制免疫反应基因1(IRG1)活性的能力，适用于癌症、炎症及自身免疫性疾病的研究领域。
T78212	KRAS G12D inhibitor 18 KRAS G12D IN 18	Others	Others
	KRAS G12D inhibitor 18 为一种有效的 KRAS G12D 抑制剂，具有潜在的抗肿瘤和抑制肿瘤细胞增殖的活性，可用于研究胰腺癌。
T3545	RG13022 RG 13022,Tyrphostin RG13022	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	RG13022 (Tyrphostin RG13022) 是一种酪氨酸激酶抑制剂，抑制EGF 受体自身磷酸化的IC50值为4 μM。
T2034	AG1557 AG-1557,AG 1557	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	AG1557 (AG-1557) 是一种表皮生长因子受体(EGFR) 酪氨酸激酶抑制剂，pIC50值为 8.194。
T4092	AG126 Tyrphostin AG126,AG 126	ERK; COX	Immunology/Inflammation; MAPK; Neuroscience
	AG126 (Tyrphostin AG126) 是一种酪氨酸激酶抑制剂，可阻止丝裂原活化蛋白激酶 p42MAPK(ERK2) 的激活。
T39156	NHS-PEG1-SS-PEG1-NHS NHS-PEG1-SS-PEG1-NHS
	NHS-PEG1-SS-PEG1-NHS 是一种可逆的、可用于生物大分子与活性小分子相互作用的链接剂。NHS-PEG1-SS-PEG1-NHS 可有效地用于蛋白质脂质体或纳米颗粒的连接。
T40024	Pomalidomide-PEG1-CO2H Pomalidomide-PEG1-C2-COOH	E3 Ligase Ligand-Linker Conjugate	PROTAC
	Pomalidomide-PEG1-CO2H 是一种合成的 E3 连接酶配体-接头偶联物，包含基于 Pomalidomide 的 cereblon 配体和 2 单元 PEG 接头。
T7821	DG172 dihydrochloride DG172 (dihydrochloride),DG-172 dihydrochloride	PPAR	DNA Damage/DNA Repair; Metabolism
	DG172 dihydrochloride (DG-172 dihydrochloride) 是一种 PPARβ/δ拮抗剂，IC50值为 27 nM。

化合物

Cat.No: T4661

Target: PKA

Aflatoxin G1-13C17

Cat.No: T35520

Synonym: Aflatoxin G1-13C17

Cucumarioside G1

Cat.No: TP2427

Aflatoxin G1 9,10-epoxide

Cat.No: T29690

Cat.No: T15364

Target: Estrogen Receptor/ERR, GPR

Cat.No: T126188

Cat.No: T126090

Gypsophilasaponin G1

Cat.No: T126031

Cat.No: T25199

Synonym: Cafaminolum,G1,G-1,G 1

Ganglioside GT1b Mixture (sodium salt)

Cat.No: T36862

Synonym: Ganglioside GT1b Mixture (sodium salt),Ganglioside G1 Mixture

t-BuXPhos Pd G1

Cat.No: T66450

Cat.No: T64659

Cat.No: T7969

Target: Others

Cat.No: T7057

Target: Histone Demethylase, Others

Cat.No: T7791

Synonym: CC-220

Target: Apoptosis, Ligand for E3 Ligase

Cat.No: T1862

Synonym: PR 619,2,6-Diamino-3,5-dithiocyanopyridine

Target: Apoptosis, DUB, Autophagy

Cat.No: T8616

Synonym: N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide

Target: transporter

RuPhos Pd G1 Methyl t-Butyl Ether Adduct

Cat.No: T64624

Cat.No: T24754

Synonym: SAG-1.5,SAG1.5,SAG 1.5

Target: Hedgehog/Smoothened

Azido-PEG11-azide

Cat.No: T17483

Synonym: 叠氮-十一聚乙二醇-叠氮

Target: Others, PROTAC Linker

Cat.No: T7389

Target: Estrogen Receptor/ERR

Cat.No: T2038

Synonym: N-Phthalyl-L-tryptophan

Target: DNA Methyltransferase

Tyrphostin AG1433

Cat.No: T13238

Synonym: SU1433,AG1433

Target: VEGFR, PDGFR

Propargyl-PEG12-bromide

Cat.No: T18566

Target: Others, PROTAC Linker

Hydroxy-PEG10-acid

Cat.No: T18031

Synonym: HO-PEG10-CH2CH2COOH

Target: Others, PROTAC Linker

BRM/BRG1 ATP Inhibitor-1

Cat.No: T10616

Target: Epigenetic Reader Domain

Mal-PEG1-Val-Cit-OH

Cat.No: T18267

Target: Others

Cat.No: T3065

Target: Apoptosis, FLT, c-RET, JAK, Autophagy

Cat.No: T7083

Synonym: ABBV-974

Target: CFTR, Autophagy

Cat.No: T8780

Synonym: INT-131,AMG-131,CHS 131

Target: PPAR

(S,R,S)-AHPC-PEG1-N3

Cat.No: T17920

Synonym: VHL Ligand-Linker Conjugates 9,VH032-PEG1-N3,E3 ligase Ligand-Linker Conjugates 3

Target: Others, Ligand for E3 Ligase

Cbz-NH-PEG12-C2-acid

Cat.No: T17719

Target: Others, PROTAC Linker

Cat.No: T11411

Target: GPR, Others

Boc-NH-PEG11-OH

Cat.No: T17666

Synonym: 叔丁氧羰基十一聚乙二醇羟基

Target: Others, PROTAC Linker

Biotin-PEG12-NHS ester

Cat.No: T17561

Synonym: 生物素十二聚乙二醇琥珀酰亚胺酯

Target: Others, PROTAC Linker

Azide-PEG12-alcohol

Cat.No: T17464

Target: Others, PROTAC Linker

Amino-PEG12-acid

Cat.No: T17405

Target: Others, PROTAC Linker

Cat.No: T18125

Synonym: 甲基-十一乙二醇-溴代

Target: Others, PROTAC Linker

Cat.No: T18132

Synonym: 十一乙二醇单甲醚丙酸

Target: Others, PROTAC Linker

Cat.No: T9961

Target: DNA/RNA Synthesis

BRM/BRG1 ATP Inhibitor-2

Cat.No: T60032

Target: Epigenetic Reader Domain

Propargyl-PEG11-methane

Cat.No: T18568

Target: Others, PROTAC Linker

Cat.No: T78525

Target: Others

KRAS G12D inhibitor 18

Cat.No: T78212

Synonym: KRAS G12D IN 18

Target: Others

Cat.No: T3545

Synonym: RG 13022,Tyrphostin RG13022

Target: EGFR

Cat.No: T2034

Synonym: AG-1557,AG 1557

Target: EGFR, HER

Cat.No: T4092

Synonym: Tyrphostin AG126,AG 126

Target: ERK, COX

NHS-PEG1-SS-PEG1-NHS

Cat.No: T39156

Synonym: NHS-PEG1-SS-PEG1-NHS

Pomalidomide-PEG1-CO2H

Cat.No: T40024

Synonym: Pomalidomide-PEG1-C2-COOH

Target: E3 Ligase Ligand-Linker Conjugate

DG172 dihydrochloride

Cat.No: T7821

Synonym: DG172 (dihydrochloride),DG-172 dihydrochloride

Target: PPAR

Cat. No.	Product Name	Target	Signaling Pathways
TN1555	Platycoside G1 桔梗皂苷G1,Deapi-platycoside E	Others	Others
	Platycoside G1 (Deapi-platycoside E) 是一种从桔梗中发现的天然三萜皂苷。它具有较强的抗氧化作用。
TN1359	Aflatoxin G1 黄曲霉毒素G1,黄曲霉毒素 G1	TNF; NF-κB	Apoptosis; NF-κB
	Aflatoxin G1 (AFG1 ), a member of the AF family with cytotoxic and carcinogenic properties, could cause DNA damage in alveolar type II (AT-II) cells and induce lung adenocarcinoma.
T3S0218	Thonningianin A	Apoptosis; Others	Apoptosis; Others
	Thonningianin A 是从非洲草药通宁宁的甲醇提取物中，分离得到的一种鞣花素，具有抗癌和抗氧化性，涉及自由基清除、抗超氧化物形成和金属螯合。
T3S1416	Decursin Decursinol angelate,前胡素,(+)-Decursin,紫花前胡素	Apoptosis; PKC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling
	Decursin (Decursinol angelate) 是一种细胞毒性剂，是一种来自朝鲜当归根的有效蛋白激酶 C 激活剂。它通过 Hippo/YAP 信号通路抑制 HepG2 细胞的生长。它通过下调 CXCR7 表达来抑制胃癌中的肿瘤生长，迁移和侵袭。
T1882	Meisoindigo N-Methylisoindigotin,Methylisoindigotin,Natura-α,甲异靛,Dian III,异甲靛	Apoptosis	Apoptosis
	Meisoindigo (Natura-α) 是 Indirubin 的衍生物，可以造成急性髓细胞性白血病细胞周期在 G0/G1 期停滞，并诱导凋亡，具有高抗肿瘤活性。
T2777	Ginsenoside Rg1 Sanchinoside C1,Panaxoside Rg1,Sanchinoside Rg1,人参皂苷Rg1,Panaxoside A,人参皂苷 Rg1,Ginsenoside A2	Apoptosis; Beta Amyloid; NF-κB	Apoptosis; Neuroscience; NF-κB
	Ginsenoside Rg1 (Panaxoside Rg1) 是人参的主要活性成分之一，可减少NF-κB 核易位。它改善认知功能受损，通过降低大脑Aβ水平来发挥作用。
T2996	Tetrandrine NSC-77037,d-Tetrandrine,Hanfangchin A,粉防己碱,Fanchinine,Sinomenine A,汉防己甲素	Potassium Channel; Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Tetrandrine (Sinomenine A) 是来自粉防己的一种双苯基异喹啉生物碱，可抑制电压门控钙离子通道 (ICa) 和 Ca2+激活的钾离子通道。
TJS0487	(-)-Syringaresinol DL-Syringaresinol,Lirioresinol b,(-)-丁香脂素	Others	Others
	(-)-Syringaresinol (DL-Syringaresinol) 来源于番荔枝 Annona Montana 的茎。 (-)-Syringaresinol 通过 G1 期阻滞和诱导细胞凋亡来抑制人早幼粒细胞 HL-60 细胞的增殖，并具有抗癌活性。
TN1805	Isosilybin B	Apoptosis; Androgen Receptor	Apoptosis; Endocrinology/Hormones
	Isosilybin B 是一种从水飞蓟中提取的黄酮木脂素，具有抗前列腺癌 (PCA) 活性，对癌细胞增殖有抑制作用，促使 G1 期阻滞和凋亡。Isosilybin B 诱导雄激素受体降解。
T3805	Prim-O-glucosylcimifugin 升麻苷,Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside	TNF; COX; JAK; NO Synthase	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells
	Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) 具有强效的抗炎作用。通过调节 JAK2/STAT3 信号传导可抑制iNOS 和COX-2表达。
T2S1396	3-O-Acetyloleanolic acid 齐墩果酸3-乙酸酯,齐墩果酸 3-乙酸酯	Apoptosis	Apoptosis
	3-O-Acetyloleanolic acid 是从 Vigna sinensisK. 种子中提取得到的一种齐墩果醇酸，可诱导癌细胞凋亡并拥有抗血管生成作用。
T3314	Perillyl alcohol Isocarveol,Perilla alcohol,紫苏醇	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	Perillyl alcohol (Isocarveol) 是一种单萜，可在不影响正常细胞的情况下诱导肿瘤细胞凋亡。
T2S2043	Dracorhodin perchlorate Dracorhodin perochlorate,血竭素高氯酸盐,Dracohodin perochlorate	Apoptosis; Others	Apoptosis; Others
	Dracorhodin perchlorate 是来源于中药血竭的一种天然产物。它抑制细胞生长，并以剂量和时间依赖性方式诱导成纤维细胞凋亡，将细胞周期阻滞在 G1 期，可作为抗乳腺癌的候选药物。
TN1222	26-Deoxyactein 27-Deoxyactein,脱氧升麻烃,23-epi-26-Deoxyactein,27-脱氧升麻亭	NOS; CDK; NO Synthase	Cell Cycle/Checkpoint; Immunology/Inflammation
	23-epi-26-Deoxyactein (27-Deoxyactein) 是一种黑升麻中的主要成分，能够阻止 TCDD 诱导的成骨细胞的损伤。它对 AhR，CYP1A1 和 ERK 的水平升高具有抑制作用。
T3386	Kaempferitrin Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside,山奈苷	cell cycle arrest; Glucokinase; IGF-1R	Cell Cycle/Checkpoint; Metabolism; Tyrosine Kinase/Adaptors
	Kaempferitrin (Lespenephryl) 是天然黄酮苷类化合物，具有缓解疼痛、抗糖尿病、消炎、抗肿瘤和化疗作用，可激活胰岛素信号传导。
T37067	9-hydroxy Stearic Acid	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	9-hydroxy Stearic Acid 是一种羟基脂肪酸，是9-PAHSA 的活性代谢物。9-hydroxy Stearic Acid 是由9-PAHSA 通过肝脏和胰腺的羧基酯脂肪酶形成的。9-hydroxy Stearic Acid (5 μM)抑制HT-29结肠癌细胞裂解物中组蛋白去乙酰化酶1 (HDAC1)的表达。3 .当浓度为100 μM.1时，可抑制HT-29细胞的增殖，并诱导细胞周期阻滞于G0/ g1期。
T2S2215	Crebanine	Apoptosis; Others; Akt	Apoptosis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling
	Crebanine 是来自于韦诺萨千金藤的一种生物碱，通过抑制 MAPKs 和 Akt 信号通路表现出抗炎活性，还具有抗心律失常的作用。它可诱导人类癌细胞的 G1阻滞和凋亡。
TWP2911	Thymidine beta-胸苷,5-Methyldeoxyuridine,Deoxyribothymidine,DThyd,NSC 21548,Thymidin	Others; DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	Thymidine (DThyd) 是一种细胞同步剂，是脱氧核糖核酸的特殊前体。它可在 DNA 复制前在 G1/S 边界阻滞细胞，是DNA 合成抑制因子。
TCO2745	Cyclic AMP Adenosine 3',5'-cyclophosphate,cAMP,腺苷环磷酸酯,环磷腺苷,Cyclic 3',5'-monophosphate adenosine,3',5'-AMP,Adenosine Cyclophosphate	Others; Endogenous Metabolite	Metabolism; Others
	Cyclic AMP (cAMP)(Adenosine 3',5'-cyclophosphate) 是有丝分裂信使，可以促进 G1期到 S 期的细胞周期进程。
T5795	Suberosin 软木花椒素	Others; NF-κB	NF-κB; Others
	Suberosin 可分离自Plumbago zeylanica 中，通过调节NF-AT 和NF-κB，抑制PHA-诱导的 PBMC 细胞增殖并捕获细胞周期G1过渡到 S 期，具有抗炎和抗血凝的活性。
T6S1917	Schisandrol B Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B	P450; Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Schisandrol B (Besigomsin) 是华中五味子的主要活性成分，具有保肝、抗炎、抗糖尿病和抗氧化的作用。它抑制活性氧的产生，也抑制 P-糖蛋白和CYP3A 的活性。
T0683	Mevastatin Compactin,ML236B,美伐他汀	Apoptosis; Antibacterial; Antibiotic; HMG-CoA Reductase; Autophagy; Lipid	Apoptosis; Autophagy; Metabolism; Microbiology/Virology
	Mevastatin (ML236B) 是他汀类 HMG-CoA 还原酶抑制剂。它是一种降脂药，可诱导细胞凋亡，将癌细胞阻滞在 G0/G1期。它还可增加内皮型一氧化氮合酶的 mRNA 和蛋白质水平。它有抗肿瘤活性，用于心血管疾病的研究。
TN1804	Isosilybin A 异水飞蓟素 A,异水飞蓟宾A,水飞蓟素 B2	Apoptosis; Tyrosinase; PPAR; ABC	Apoptosis; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Proteases/Proteasome
	Isosilybin A 是从水飞蓟中分离出来的一种黄酮木脂素，可抑制癌细胞增殖并诱导 G1 期停滞和凋亡，通过靶向 Akt-NF-κB-雄激素受体轴激活前列腺癌细胞的凋亡机制，具有抗前列腺癌活性。
T13534	Aflatoxin M1 黄曲霉毒素 M1	Others	Others
	Aflatoxin M1, a significant metabolite of Aflatoxin B1, is a mycotoxin synthesized by Aspergillus flavus and Aspergillus parasiticus fungi. Toxicity levels of Aflatoxins follow the order: Aflatoxin B1 > Aflatoxin M1 > Aflatoxin G1 > Aflatoxin B2 > Aflatoxin M2 > Aflatoxin G2.
TN2400	alpha-Terthienylmethanol	Others	Others
	Alpha-terthienylmethanol possesses potent cytotoxic activity against human endometrial cancer cells; it inhibits growth mediated by the induction of apoptosis, as shown by the accumulation of sub-G1 and apoptotic cells.
T75630	Ganoderic acid Mf
	Ganoderic acid Mf为具有抗肿瘤活性的三萜类化合物，能导致细胞周期在G1期停滞，并在正常细胞与癌细胞中显示高度选择性，通过线粒体介导途径促进细胞凋亡(apoptosis)。
TN1464	Camellianin A	RAAS	Endocrinology/Hormones
	Camellianin A has anticancer activity, it can inhibit the proliferation of the human hepatocellular liver carcinoma Hep G2 and human breast adenocarcinoma MCF-7 cell lines in a dose-dependent manner and induce the significant increase of the G0/G1 cell po
T16942	Sterigmatocystine	Others	Others
	Sterigmatocystine is an inhibitor of G1 Phase and DNA synthesis and is used to inhibit p21 activity. Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor.
TMA0918	Neochamaejasmine A	Caspase	Apoptosis; Proteases/Proteasome
	Neochamaejasmin A can inhibit cellular (3)H-thymidine incorporation (IC 50 12.5 microg/mL) and subsequent proliferation of human prostate cancer LNCaP cells, it blocks cell cycle progression at the G1 phase by activating the p21 protein and ultimately pro
T75621	Secalonic acid D
	Secalonic acid D 是一种抗肿瘤细胞的有毒化合物。Secalonic acid D 可以从Aspergillus aculeatus 的代谢产物中分离得到。Secalonic acid D 激活GSK3-β，并降解β-catenin。因此，Secalonic acid D 下调c-Myc 表达，使细胞周期停滞在 G1 期，诱导细胞凋亡 (apoptosis)。
T79971	Asparanin A	Apoptosis	Apoptosis
	Asparanin A 是一种具有抗癌活性的凋亡 (apoptosis) 诱导剂。它能够通过线粒体和 PI3K/AKT 信号通路使细胞周期在 G0/G1 期停滞，并有效抑制癌细胞生长。此外，Asparanin A 在小鼠Ishikawa子宫内膜癌异种移植模型中显示出显著的体内抑制肿瘤生长效力。
TN4263	Isoangustone A	MMP; GSK-3; NF-κB; ROS; Akt; PI3K; CDK; JNK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Isoangustone A dampens mesangial sclerosis associated with inflammation in response to high glucose through hindering TGF-β and NF-ÎºB signaling. Isoangustone A also shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals.
TN3719	Cristacarpin	p38 MAPK; ROS; CDK; Antifection; p53	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; MAPK; Microbiology/Virology
	Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-lethal reactive oxygen species (ROS) generation and which eventually terminates by triggering s
T38243	Hygrolidin
	Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus. It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC50s = 2.9, 5.2, and 33 ng/ml, respectively). Hygrolidin induces the expression and levels of p21 in DLD-1 cells, but not WI-38 fibroblasts, and leads to cell accumulation in the G1 and S phases without inducing apoptosis. It has antiparasitic activity against T. cruzi, L. donovan...
TN3438	Arborinine	HCV Protease; Antifection	Microbiology/Virology; Proteases/Proteasome
	Arborinine shows mild in vitro antibacterial activity, it possesses moderate levels of anti-hepatitis C virus(HCV) activities with the IC50 values being 6.4 ± 0.7 ug/ml. Arborinine shows antifeedant activity against Spodoptera frugiperda. Arborinin shows
TN3587	Capillarisin	MMP; ERK; IL Receptor; BCL; VEGFR; TNF; NOS; NF-κB; TLR; MAPK; COX; DNA/RNA Synthesis; Prostaglandin Receptor; JNK; STAT	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by inducing apoptosis accompanied with
T36954	Nemorosone
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...

天然产物

Cat.No: TN1555

Synonym: 桔梗皂苷G1,Deapi-platycoside E

Target: Others

Cat.No: TN1359

Synonym: 黄曲霉毒素G1,黄曲霉毒素 G1

Target: TNF, NF-κB

Thonningianin A

Cat.No: T3S0218

Target: Apoptosis, Others

Cat.No: T3S1416

Synonym: Decursinol angelate,前胡素,(+)-Decursin,紫花前胡素

Target: Apoptosis, PKC

Cat.No: T1882

Synonym: N-Methylisoindigotin,Methylisoindigotin,Natura-α,甲异靛,Dian III,异甲靛

Target: Apoptosis

Ginsenoside Rg1

Cat.No: T2777

Synonym: Sanchinoside C1,Panaxoside Rg1,Sanchinoside Rg1,人参皂苷Rg1,Panaxoside A,人参皂苷 Rg1,Ginsenoside A2

Target: Apoptosis, Beta Amyloid, NF-κB

Cat.No: T2996

Synonym: NSC-77037,d-Tetrandrine,Hanfangchin A,粉防己碱,Fanchinine,Sinomenine A,汉防己甲素

Target: Potassium Channel, Calcium Channel

(-)-Syringaresinol

Cat.No: TJS0487

Synonym: DL-Syringaresinol,Lirioresinol b,(-)-丁香脂素

Target: Others

Cat.No: TN1805

Target: Apoptosis, Androgen Receptor

Prim-O-glucosylcimifugin

Cat.No: T3805

Synonym: 升麻苷,Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside

Target: TNF, COX, JAK, NO Synthase

3-O-Acetyloleanolic acid

Cat.No: T2S1396

Synonym: 齐墩果酸3-乙酸酯,齐墩果酸 3-乙酸酯

Target: Apoptosis

Perillyl alcohol

Cat.No: T3314

Synonym: Isocarveol,Perilla alcohol,紫苏醇

Target: Apoptosis, Endogenous Metabolite

Dracorhodin perchlorate

Cat.No: T2S2043

Synonym: Dracorhodin perochlorate,血竭素高氯酸盐,Dracohodin perochlorate

Target: Apoptosis, Others

Cat.No: TN1222

Synonym: 27-Deoxyactein,脱氧升麻烃,23-epi-26-Deoxyactein,27-脱氧升麻亭

Target: NOS, CDK, NO Synthase

Cat.No: T3386

Synonym: Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside,山奈苷

Target: cell cycle arrest, Glucokinase, IGF-1R

9-hydroxy Stearic Acid

Cat.No: T37067

Target: HDAC

Cat.No: T2S2215

Target: Apoptosis, Others, Akt

Cat.No: TWP2911

Synonym: beta-胸苷,5-Methyldeoxyuridine,Deoxyribothymidine,DThyd,NSC 21548,Thymidin

Target: Others, DNA/RNA Synthesis, Endogenous Metabolite

Cat.No: TCO2745

Synonym: Adenosine 3',5'-cyclophosphate,cAMP,腺苷环磷酸酯,环磷腺苷,Cyclic 3',5'-monophosphate adenosine,3',5'-AMP,Adenosine Cyclophosphate

Target: Others, Endogenous Metabolite

Cat.No: T5795

Synonym: 软木花椒素

Target: Others, NF-κB

Cat.No: T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

Cat.No: T0683

Synonym: Compactin,ML236B,美伐他汀

Target: Apoptosis, Antibacterial, Antibiotic, HMG-CoA Reductase, Autophagy, Lipid

Cat.No: TN1804

Synonym: 异水飞蓟素 A,异水飞蓟宾A,水飞蓟素 B2

Target: Apoptosis, Tyrosinase, PPAR, ABC

Cat.No: T13534

Synonym: 黄曲霉毒素 M1

Target: Others

alpha-Terthienylmethanol

Cat.No: TN2400

Target: Others

Ganoderic acid Mf

Cat.No: T75630

Cat.No: TN1464

Target: RAAS

Sterigmatocystine

Cat.No: T16942

Target: Others

Neochamaejasmine A

Cat.No: TMA0918

Target: Caspase

Secalonic acid D

Cat.No: T75621

Cat.No: T79971

Target: Apoptosis

Cat.No: TN4263

Target: MMP, GSK-3, NF-κB, ROS, Akt, PI3K, CDK, JNK

Cat.No: TN3719

Target: p38 MAPK, ROS, CDK, Antifection, p53

Cat.No: T38243

Cat.No: TN3438

Target: HCV Protease, Antifection

Cat.No: TN3587

Target: MMP, ERK, IL Receptor, BCL, VEGFR, TNF, NOS, NF-κB, TLR, MAPK, COX, DNA/RNA Synthesis, Prostaglandin Receptor, JNK, STAT

Cat.No: T36954

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