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Search Results for " antinociceptive "

84

抑制剂 & 化合物

63

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T23498	UNC3230 UNC 3230	Others	Others
	UNC3230 是一种 ATP 竞争性的磷脂酰肌醇 4 磷酸 5 激酶 1C 型 (PIP5K1C) 选择性抑制剂，其IC50约为 41 nM。它还可抑制PIP4K2C，但对其他调节磷酸肌醇水平的脂质激酶无抑制作用。它具有缓解疼痛和抗癌特性。
T6554	JZL 184 JZL184	Lipase	Metabolism
	JZL 184 是不可逆的、选择性的MAGL 抑制剂，对MAGL 的选择性比 FAAH 高 300 倍以上。它可阻断脑膜中的 2-花生四烯酸甘油酯 (2-AG) 的水解 (IC50为 8 nM)。
T9461	AZ194	Sodium Channel	Membrane transporter/Ion channel
	CRMP2-Ubc9-NaV1.7 inhibitor 194 是一流的CRMP2-Ubc9相互作用抑制剂及NaV1.7抑制剂 (IC50=1.2 μM)，口服有活性，具有抗伤害作用。AZ194 阻断 CRMP2 的 SUMOylation 以选择性地减少表面表达 NaV1.7 的量。
T1191L	Metamizole sodium 安乃近,Analgin,安乃近钠盐(诺瓦经),Dipyron	COX	Immunology/Inflammation; Neuroscience
	Metamizole sodium (Analgin) 是一种环氧合酶-3 (COX-3) 抑制剂，具有良好的解热作用，可用于缓解疼痛的研究。
T22733	DL-AP5 DL-2-氨基-5-膦酰基缬草酸	NMDAR	Neuroscience
	DL-AP5 是选择性 N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂的外消旋形式，具有抗惊厥作用。
T15781	LP-935509	Serine/threonin kinase; AAK1 (AP2 associated kinase 1)	Cell Cycle/Checkpoint; Metabolism; Neuroscience
	LP-935509 是一种选择性的、具有脑渗透的、小分子的衔接蛋白-2 相关激酶1 (AAK1) ATP 竞争性抑制剂，其 IC50=3.3 nM，Ki=0.9 nM。它是一种 BIKE 的有效抑制剂 (IC50=14 nM) 和中度的 GAK 抑制剂 (IC50=320 nM)。它能够逆转 SNL 手术后的疼痛。
T28118	MSP3 MSP-3,MSP 3	TRP/TRPV Channel	Membrane transporter/Ion channel
	MSP3 是瞬时受体电位香草素 1 型的激动剂 (EC50 = 0.87 μM) ，具有镇痛和神经保护作用。
T39284	EST73502 HCl	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	EST73502 是 μ-阿片受体激动剂 (Ki = 64 nM) 激动剂和 σ1 受体拮抗剂 (Ki = 118 nM)。 EST73502 显示出镇痛活性。
T11516	GV-196771A	NMDAR	Neuroscience
	GV-196771A 一种新型的NMDA受体甘氨酸位点拮抗剂，具有强大的抗痛觉过敏活性。
T21380	Pravadoline WIN 48098-6,WIN48098-6,普拉朵林,WIN-48098-6	Cannabinoid Receptor	GPCR/G Protein
	Pravadoline (WIN48098-6) 是一种 cannabinoid 受体激动剂。 Pravadoline 抑制小鼠大脑中的 PGs 合成，并在受到各种热、化学和机械伤害性刺激的啮齿动物中显示出镇痛活性。
T23076L	Nociceptin (1-7) acetate	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Nociceptin (1-7) acetate 是一种有效的阿片受体样受体 1 (ORL1) 受体激动剂。 Nociceptin (1-7) 与 nociceptin 结合可降低痛觉过敏并具有镇痛活性。
TP1905	BW-180C (D-丙2,D-亮5)-脑啡肽,DADLE	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	BW-180C (DADLE) 是水溶性的多肽类δ-阿片受体激动剂，也对 μ-阿片受体显示活性，在体内表现出镇痛活性。
T22051	BU 224 hydrochloride	Imidazoline Receptor	Neuroscience
	BU 224 hydrochloride 是一种选择性的咪唑啉 I(2) 结合位点配体，具有镇痛和抗抑郁样活性。
TP2036L	DPDPE TFA (88373-73-3 free base) DPDPE TFA	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	DPDPE TFA 是选择性 δ-阿片受体激动剂肽，在体内具有镇痛作用。
TP1212	N-Boc-Phe-Leu-Phe-Leu-Phe Boc-FLFLF	Others	Others
	N-Boc-Phe-Leu-Phe-Leu-Phe (Boc-FLFLF) 是甲酰肽受体 1(FPR1)拮抗剂，能够增加疼痛作用，抑制膜联蛋白的抗疼痛活性。
T17309	(R)-(-)-Ibuprofen levibuprofen,(R)-Ibuprofen	NF-κB	NF-κB
	(R)-(-)-Ibuprofen ((R)-Ibuprofen) 是 Ibuprofen 的 R 型异构体，对 COX 无作用，可以抑制 NF-κB 的活化；(R)-(-)-Ibuprofen 具有抗炎作用，可用于缓解疼痛的研究。
T10593	BPR1M97	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	BPR1M97 是一种具有血脑屏障渗透性和有效性的 mu 阿片受体（MOP）和神经肽-啡肽 FQ（NOP）受体激动剂，对 MOP 的 Kis 值为1.8 nM，对 NOP 的Kis 值为 4.2 nM。BPR1M97 具有抗伤害作用和抗痛觉作用。
T22037	AS 1892802	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	AS 1892802是一种强效和选择性的ROCK 抑制剂。AS 1892802 用于人ROCK2、大鼠ROCK2和人ROCK1的 IC50值分别为52nM、57nM 和122nM。AS 1892802的镇痛作用起效速度与曲马多和双氯芬酸的起效速度一样快。
TP1404L	Hemorphin-7 acetate(152685-85-3 free base)	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Hemorphin-7 acetate(152685-85-3 free base) 是一种 hemorphin 肽，一种源自血红蛋白 β 链的内源性阿片肽。 Hemorphin 肽具有镇痛和抗高血压活性，可激活阿片受体并抑制血管紧张素转换酶 (ACE)。
T0678	Amitriptyline hydrochloride Amitriptyline HCl,Tryptizol,盐酸阿米替林,Domical,Annoyltin	Trk receptor; Sigma receptor; 5-HT Receptor; Serotonin Transporter; Sodium Channel; Adrenergic Receptor; AChR; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; Tyrosine Kinase/Adaptors
	Amitriptyline hydrochloride (Annoyltin) 是血清素再摄取转运体和去甲肾上腺素再摄取转运体抑制剂，还与多巴胺再摄取转运体结合，其Ki 为 2.58 μM。它也抑制肾上腺素能受体、毒蕈碱受体、组胺受体、5-羟色胺受体。它是TrkA 和TrkA 受体的激动剂，具有强神经营养活性和有抗抑郁作用。
T10572	BMT-124110	AAK1 (AP2 associated kinase 1)	Neuroscience
	BMT-124110是一种具有选择性的AAK1抑制剂(IC50: 0.9 nM)，具有抗伤害感受活性。BMT-090605抑制BMP -2诱导蛋白激酶BIKE,其IC50为 17 nM。BMT-090605抑制细胞周期蛋白 G 相关激酶GAK，其IC50:为99 nM。
T34081	Piromelatine NEU-P-11,NEU-P 11,NEU-P11	P2X Receptor; 5-HT Receptor; MT Receptor; Sodium Channel; TRP/TRPV Channel	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Piromelatine 是褪黑激素 MT1/MT2 受体、5-HT1A 和 5-HT1D 的激动剂，也是 5-HT2B 的拮抗剂。Piromelatine 具有抗痛觉活性，对 P2X3、TRPV1 和 Nav1.7 通道有抑制作用，可用于促进睡眠、缓解疼痛、抗神经退行性疾病和抗抑郁疾病的研究。
TP1179L	Porcine dynorphin A(1-13) acetate Dynorphin A Porcine Fragment 1-13 acetate,Porcine dynorphin A(1-13) acetate(72957-38-1 free base)	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Porcine dynorphin A(1-13) acetate (Dynorphin A Porcine Fragment 1-13 acetate)(72957-38-1 free base) 是一种有效的内源性 κ opioid 受体激动剂，在生理浓度下具有镇痛作用。暴露于强啡肽 A (1-13) 会导致单个神经元中 [Ca2+]i 的急剧增加，类似于急性 NMDA 治疗所见的增加。
TP1901L1	Hemopressin (rat) acetate(568588-77-2 free base)	Cannabinoid Receptor	GPCR/G Protein
	Hemopressin (rat) acetate(568588-77-2 free base) 是一种衍生自血红蛋白 α1 链的九肽，起初是从大鼠脑匀浆中分离出来的。 Hemopressin 是 CB2 大麻素受体的口服活性、选择性和反向激动剂。 Hemopressin 在炎性疼痛模型中发挥镇痛作用。
T4436	RO1138452 CAY10441	Others; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Others
	RO1138452 (CAY10441) 是一种选择性和可口服的前列环素受体拮抗剂，pKi 为8.3。它拮抗卡前列环素诱导的人神经母细胞瘤腺苷酸环化酶的激活，以剂量依赖性方式阻断环 AMP 积累，具有镇痛活性。
TP1559L	Ziconotide Acetate (107452-89-1 free base) 醋酸齐考诺肽,Prialt,Ziconotide Acetate	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Ziconotide Acetate (107452-89-1 free base) (Prialt) 是一种镇痛剂，已用于治疗神经性和非神经性疼痛。 Ziconotide 通过与位于伤害感受通路初级传入神经元末端部分的 N 型钙通道结合起作用，因此通过有效的镇痛作用减少突触传递。
T8414	SNC 80 Snc-80,SNC80,NIH 10815	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	SNC 80 (NIH 10815) 是有效的，高度选择性的非肽类 δ 阿片 (δ-opioid) 受体激动剂，Ki 为1.78 nM，IC50 为 2.73 nM。SNC80 还以 EC50 为 52.8 nM 来选择性激活 HEK293 细胞中的 μ-δ 异聚体。SNC80 具有抗伤害性，抗痛觉过敏和抗抑郁样作用，并可用于多种头痛症的研究。
TP1900L1	Hemopressin (human, mouse) acetate Hemopressin (human, mouse) acetate(1314035-51-2 free base)	Cannabinoid Receptor	GPCR/G Protein
	Hemopressin (human, mouse) acetate(1314035-51-2 free base) 是一种衍生自血红蛋白 α1 链的九肽，是从大鼠脑匀浆中分离出来的。 Hemopressin 是 CB1 大麻素受体的口服活性、选择性和反向激动剂。 Hemopressin 在炎性疼痛模型中发挥镇痛作用。
T27363	FR 64822 FR-64822,FR64822
	FR64822(N-(4-pyridylcarbamoyl)amino 1,2,3,6,-tetrahydropyridine), a novel non-opioid antinociceptive compound, displays antinociceptive activities in a variety of assays with mice and rats. It has a strong antinociceptive activity in the acetic acid writh
T23580	20681-S 20681 S
	20681-S has narcotic antagonistic properties and antinociceptive.
T69134	Metanicotine
	Metanicotine is a selective nicotinic agonist with antinociceptive properties.
T69847	O-1057 free base
	O-1057 free base is a water-soluble cannabinoid receptor agonist with antinociceptive properties. RESEARCH USE ONLY.
T20912	DBO-83 DBO83
	DBO-83, an agonist of nicotinic acetylcholine receptors (nAChRs), has anti-amnesic and antinociceptive activities.
T70728	Vadaclidine
	Vadaclidine is an orally acting antinociceptive muscarinic agonist.
T69848	O-1057 hydrochloride
	O-1057 hydrochloride is a water-soluble cannabinoid receptor agonist with antinociceptive properties. RESEARCH USE ONLY.
T11721L	JDTic dihydrochloride	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JDTic is a potent antagonist of kappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception.
T25490	Hemorphin 4 Tyr-pro-trp-thr
	Hemorphin 4 is an endogenous opioid peptide of the hemorphin family which has antinociceptive properties and is derived from the β-chain of hemoglobin in the bloodstream.
T27968	M-5011 T-3788,S-MTPPA,M 5011,M-5011C
	M-5011 is a non-steroidal anti-inflammatory drug and immunomodulator potentially for the treatment of inflammation and pain. M-5011 had an effective antinociceptive activity (ED50 value) of 0.63 mg/kg. M-5011 partially inhibits the generalized bone loss a
T61708	AZD 2066 hydrate
	AZD 2066 hydrate is a selective, orally active, and brain-penetrant antagonist of mGluR5. It exhibits antinociceptive effects [1].
T28516	ReN-1869 NNC-05-1869,NNC 05-1869,NNC-051869,ReN 1869
	ReN-1869 is a histamine H1 receptor antagonist. ReN 1869 is active against inflammation and neurogenic pain. ReN-1869 produces potent and selective antinociceptive effects on dorsal horn neurons after inflammation and neuropathy.
T28495	R-84760 hydrochloride R84760,R 84760,R 86436,R-86436,R86436
	R-84760 is a κ-opioid receptor agonist. R-84760 produces an extremely potent antinociceptive effect against tonic pain through the kappa-opioid receptors; the sites of action of subcutaneously administered R-84760 are the supraspinal and spinal loci in th
T70292	DDPM-2571 HCl
	DDPM-2571 is a highly potent and in vivo active inhibitor of GABA transporter subtype 1 with anticonvulsant, anxiolytic, antidepressant and antinociceptive properties. DDPM-2571 was quickly distributed into the brain and was highly effective in the prevention of chemically-induced seizures (pentylenetetrazole and pilocarpine models) and 6-Hz convulsions. It demonstrated significant anxiolytic-like and antidepressant-like properties. DDPM-2571 had antinociceptive properties, both in the hot plate...
TP2118	SNX-482 SNX 482
	Potent and selective, voltage-dependent R-type CaV2.3 calcium channel blocker (IC50 = 30 nM). Antinociceptive; inhibits nociceptive C-fibre and Aδ-fibre-evoked neuronal responses.
T72151	(D-Met2,Pro5)-Enkephalinamide
	(D-Met2,Pro5)-Enkephalinamide 是一种强效的阿片类激动剂，其具有抗痛活性。
T68206	Arbortristoside A
	Arbortristoside A is an anti-inflammatory and antinociceptive. This activity may be due to the inhibiting effect of prostaglandin, histamine and serotonin. Arbortristoside A has also been shown to act on ulcerations and may facilitate healing of peptic ulcers.
T15165	DPI-3290 Org 41793	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	DPI-3290 is a specific agonist of opioid receptors (Ki: 0.18 nM, 0.46 nM, and 0.62 nM for δ-, μ-, and κ-opioid receptors, respectively) with potent antinociceptive activity. DPI-3290 is one of a series of novel centrally acting agents.
TP1529	Galanin (1-19), human
	Galanin (1-19), human, represents the fragment encompassing amino acids 1 to 19 of the human galanin neuropeptide. Galanin (GAL) is known for its extensive distribution and multifaceted biological roles, such as regulating hormone secretion, providing antinociceptive effects, and altering feeding behavior.
T73307	TrkA-IN-4
	TrkA-IN-4 是一种有效和具有口服活性的 TrkA 变构抑制剂，是TrkA-IN-3 的前药。TrkA-IN-4 显示出有效的抗伤害作用。
T31220	DBO-83 free base DBO 83 free base
	DBO-83 free base 是 DBO-83的游离碱形式。游离碱 DBO-83是烟碱型乙酰胆碱受体（nAChRs）的激动剂，具有抗遗忘和抗伤害的活性。
T14691	BMT-090605	Others	Others
	BMT-090605 is a potent, selective AAK1 inhibitor, with an IC50 of 0.6 nM. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 45 and 60 nM, respectively[1]. BMT-090605 shows antinociceptive activity

化合物

Cat.No: T23498

Synonym: UNC 3230

Target: Others

Cat.No: T6554

Synonym: JZL184

Target: Lipase

Cat.No: T9461

Target: Sodium Channel

Metamizole sodium

Cat.No: T1191L

Synonym: 安乃近,Analgin,安乃近钠盐(诺瓦经),Dipyron

Target: COX

Cat.No: T22733

Synonym: DL-2-氨基-5-膦酰基缬草酸

Target: NMDAR

Cat.No: T15781

Target: Serine/threonin kinase, AAK1 (AP2 associated kinase 1)

Cat.No: T28118

Synonym: MSP-3,MSP 3

Target: TRP/TRPV Channel

Cat.No: T39284

Target: Opioid Receptor

Cat.No: T11516

Target: NMDAR

Cat.No: T21380

Synonym: WIN 48098-6,WIN48098-6,普拉朵林,WIN-48098-6

Target: Cannabinoid Receptor

Nociceptin (1-7) acetate

Cat.No: T23076L

Target: Opioid Receptor

Cat.No: TP1905

Synonym: (D-丙2,D-亮5)-脑啡肽,DADLE

Target: Opioid Receptor

BU 224 hydrochloride

Cat.No: T22051

Target: Imidazoline Receptor

DPDPE TFA (88373-73-3 free base)

Cat.No: TP2036L

Synonym: DPDPE TFA

Target: Opioid Receptor

N-Boc-Phe-Leu-Phe-Leu-Phe

Cat.No: TP1212

Synonym: Boc-FLFLF

Target: Others

(R)-(-)-Ibuprofen

Cat.No: T17309

Synonym: levibuprofen,(R)-Ibuprofen

Target: NF-κB

Cat.No: T10593

Target: Opioid Receptor

Cat.No: T22037

Target: ROCK

Hemorphin-7 acetate(152685-85-3 free base)

Cat.No: TP1404L

Target: Opioid Receptor

Amitriptyline hydrochloride

Cat.No: T0678

Synonym: Amitriptyline HCl,Tryptizol,盐酸阿米替林,Domical,Annoyltin

Target: Trk receptor, Sigma receptor, 5-HT Receptor, Serotonin Transporter, Sodium Channel, Adrenergic Receptor, AChR, Norepinephrine, Histamine Receptor

Cat.No: T10572

Target: AAK1 (AP2 associated kinase 1)

Cat.No: T34081

Synonym: NEU-P-11,NEU-P 11,NEU-P11

Target: P2X Receptor, 5-HT Receptor, MT Receptor, Sodium Channel, TRP/TRPV Channel

Porcine dynorphin A(1-13) acetate

Cat.No: TP1179L

Synonym: Dynorphin A Porcine Fragment 1-13 acetate,Porcine dynorphin A(1-13) acetate(72957-38-1 free base)

Target: Opioid Receptor

Hemopressin (rat) acetate(568588-77-2 free base)

Cat.No: TP1901L1

Target: Cannabinoid Receptor

Cat.No: T4436

Synonym: CAY10441

Target: Others, Prostaglandin Receptor

Ziconotide Acetate (107452-89-1 free base)

Cat.No: TP1559L

Synonym: 醋酸齐考诺肽,Prialt,Ziconotide Acetate

Target: Calcium Channel

Cat.No: T8414

Synonym: Snc-80,SNC80,NIH 10815

Target: Opioid Receptor

Hemopressin (human, mouse) acetate

Cat.No: TP1900L1

Synonym: Hemopressin (human, mouse) acetate(1314035-51-2 free base)

Target: Cannabinoid Receptor

Cat.No: T27363

Synonym: FR-64822,FR64822

Cat.No: T23580

Synonym: 20681 S

Cat.No: T69134

O-1057 free base

Cat.No: T69847

Cat.No: T20912

Synonym: DBO83

Cat.No: T70728

O-1057 hydrochloride

Cat.No: T69848

JDTic dihydrochloride

Cat.No: T11721L

Target: JAK

Cat.No: T25490

Synonym: Tyr-pro-trp-thr

Cat.No: T27968

Synonym: T-3788,S-MTPPA,M 5011,M-5011C

AZD 2066 hydrate

Cat.No: T61708

Cat.No: T28516

Synonym: NNC-05-1869,NNC 05-1869,NNC-051869,ReN 1869

R-84760 hydrochloride

Cat.No: T28495

Synonym: R84760,R 84760,R 86436,R-86436,R86436

Cat.No: T70292

Cat.No: TP2118

Synonym: SNX 482

(D-Met2,Pro5)-Enkephalinamide

Cat.No: T72151

Arbortristoside A

Cat.No: T68206

Cat.No: T15165

Synonym: Org 41793

Target: Opioid Receptor

Galanin (1-19), human

Cat.No: TP1529

Cat.No: T73307

DBO-83 free base

Cat.No: T31220

Synonym: DBO 83 free base

Cat.No: T14691

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T7907	7-Methoxyflavone	Others	Others
	7-Methoxyflavone 是一种分离自 Zornia brasiliensis 的化合物。它能够抑制福尔马林疼痛反应神经源期的舔爪时间 (65.6%)，有外周镇痛活性，但不影响炎症期的伤害性反映。
T6S1010	Allomatrine 槐定碱,别苦参碱	Others	Others
	Allomatrine 是一种来源槐花树皮的生物碱。它能够激活 κ-阿片受体，进而产生缓解疼痛的作用。
T3834	8-Epideoxyloganic acid 8-表去氧马钱酸	ROS; Immunology/Inflammation related	Immunology/Inflammation
	8-Epideoxyloganic acid 是从 Incarvillea delavayi 中分离得到的一种环烯醚萜苷。它具有微弱的缓解疼痛活性。
T7052	Gnetol	Tyrosinase; COX; HDAC; AChR	Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Neuroscience; Proteases/Proteasome
	Gnetol 是从买麻藤的根中分离出来的一种酚类。它是酪氨酸酶抑制剂，对鼠酪氨酸酶的 IC50为 4.5 μM，可抑制黑色素的生物合成。它有效抑制 COX-1和 HDAC，具有抗氧化、抗增殖、抗癌和保肝活性，还具有浓度依赖性的 α-淀粉酶、α-葡萄糖苷酶和脂肪形成活性。
T3254	PHYTOL 植醇,trans-Phytol,(E)-Phytol	Antibacterial; PPAR; Parasite	DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	PHYTOL (trans-Phytol) 是一种从叶绿素中提取的二萜醇，广泛应用于食品添加剂和医药领域，具有很好的抗血吸虫特性。它具有抗伤害、抗氧化、抗炎、抗过敏等作用。它对结核分枝杆菌和金黄色葡萄球菌具有抗菌活性。
T6S1653	Albiflorin Alibiflorin,芍药内酯苷	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Albiflorin (Alibiflorin) 是一种牡丹根中的主要成分，是一种单萜糖苷。它具有神经保护、抗炎、抗氧化和缓解疼痛作用。
T8014	Epoxylinalool 氧化芳樟醇,2-(2-Hydroxy-2-Propyl)-5-Methyl-5-Vinyltetrahydrofuran	Others	Others
	Epoxylinalool (2-(2-Hydroxy-2-Propyl)-5-Methyl-5-Vinyltetrahydrofuran) 是一种天然存在的单萜醇，广泛用于香水和调味品的生产。
T5S2360	Corydaline Corydalin,紫堇碱,延胡索甲素,(+)-Corydaline	P450; Virus Protease; Opioid Receptor; AChE	Endocrinology/Hormones; GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Corydaline (Corydalin) 是从 Corydalis yanhusuo 提取的一种异喹啉生物碱，是一种新型促动力植物药的主要活性成分之一。它促进胃排空和小肠转运，促进胃的调节，具有抗乙酰胆碱酯酶、抗过敏和镇痛活性。
T0437	Inosine INO 495,NSC 20262,肌苷	ROS; Endogenous Metabolite; Adenosine Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Inosine (NSC-20262) 是由腺苷分解代谢产生的一种内源性嘌呤核苷，是腺苷受体A1R 和A2AR 的激动剂，具有抗炎免疫调节，抗伤害和神经保护作用。
T5S1882	Songorine 准葛尔乌头碱,Napellonine,Zongorine,Bullatine G	Others; GABA Receptor	Membrane transporter/Ion channel; Neuroscience; Others
	Songorine (Napellonine) 是从乌头属中分离出的一种二萜生物碱，具有抗癌、抗心律不齐和抗炎活性。它是大鼠脑中的GABAA 受体拮抗剂，有用于上皮性卵巢癌的研究潜力。
T8193	α-Thujone Thujone,ALPHA-(-)-THUJONE,α-侧柏酮,(-)-α-侧柏酮	Apoptosis; Reactive Oxygen Species; GABA Receptor; AChR; Parasite; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; NF-κB
	α-Thujone 是一种从西方金钟柏精油中分离出来的单萜，可穿透血脑屏障。它是 GABAA 受体的可逆调节剂，在抑制 GABA 诱导的电流时，它的 IC50为 21 μM。它诱导 ROS 依赖性细胞毒性，还诱导细胞凋亡和自噬。它具有抗伤害，抗肿瘤、杀虫和驱虫活性。
T5S1131	Ganoderic acid C6 灵芝酸C6	Others	Others
	Ganoderic acid C6 是醛糖还原酶活性的抑制剂。
T6S0743	Sesamoside	Others	Others
	Sesamoside 是分离自鸢尾叶的茎中的萜类，具有抗氧化和抗糖基化活性。
T20225	Dicentrine, (-)- L-Dicentrine,荷包牡丹碱,NSC 251699,NSC251699,NSC-251699	Others	Others
	Dicentrine, (-)- (NSC-251699) 是一种在几种植物物种中发现的非卟啉生物碱，在小鼠内脏痛的急性模型中显示出显著的镇痛活性。
T5783	Rosamultin 野蔷薇苷,罗莎白素	Antioxidant; HIV Protease	Microbiology/Virology; oxidation-reduction; Proteases/Proteasome
	Rosamultin 是从Potentilla anserina L 分离的 19 α-羟基型三萜。它抑制 HIV-1 蛋白酶，具有抗氧化、抗炎和镇痛作用。
TN2540	1-Hydroxybaccatin I	Others	Others
	1-Hydroxybaccatin I 对对苯醌诱导的腹部收缩具有显着的镇痛活性。
TN1027	β-Amyrin β-香树脂醇,beta-Amyrin	Beta Amyloid	Neuroscience
	β-Amyrin (beta-Amyrin) 是一种番茄果实的表面蜡和蒲公英咖啡中的成分，能抑制淀粉样 β 诱导的增强效应损害。它可用于研究 AD。
T7035	ANTHRAQUINONE-2-CARBOXYLIC ACID	IRAK; Syk	Angiogenesis; Immunology/Inflammation; NF-κB; Tyrosine Kinase/Adaptors
	Anthraquinone-2-carboxylic acid 从 Brazilian taheebo 中分离得到，具有抗炎、缓解疼痛的作用。
T4833	Ac-DL-Trp-OH N-乙酰-DL-色氨酸,N-Acetyl-DL-tryptophan	Others; Endogenous Metabolite	Metabolism; Others
	Ac-DL-Trp-OH (N-Acetyl-DL-tryptophan) 是内源性代谢产物的一种。
TN1823	Kaempferol 3-O-β-D-galactopyranoside Kaempferol 3-O-beta-D-galactoside,Kaempferol-3-O-galactoside,三叶豆苷	Immunology/Inflammation related	Immunology/Inflammation
	Kaempferol 3-O-β-D-galactopyranoside 是黄酮类化合物的衍生物，分离自木樨状菌 (Consolida oliverana) 的地上部分。
T8169	Decursinol	Others	Others
	Decursinol 是一种分离自Angelica gigas 的根中的、口服具有活性的抗伤害药物。它具有抗肿瘤和抗转移作用。
T2757	Myricitrin 杨梅苷,Myricetrin,Myricitrine	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	Myricitrin (Myricitrine) 是从杨梅根皮中分离出来的类黄酮化合物，具有镇痛作用。它是主要的抗氧化剂。
T6S0627	Mesaconitine 新乌碱,新乌头碱；中乌头碱	TNF	Apoptosis
	Mesaconitine 是乌头属植物的一种主要活性成分，通过循环 AMP 和刺激中枢 β-肾上腺素能系统具有镇痛活性，还有抗炎活性。
T3409	Plantamajoside Y0160,C10485,大车前苷,车前子甙	Others	Others
	Plantamajoside (Y0160) 是一种苯丙烷类糖苷，从车前Plantago asiaticaL.中分离出来得到。它对 LPS 诱导的急性肺损伤小鼠模型具有保护作用。它对肺部炎症具有潜在的研究价值。
T5S0662	Gelsemine 钩吻碱,Gelsemin	Antioxidant	oxidation-reduction
	Gelsemine (Gelsemin) 是一种从中草药 Gelsemium elegans 中获得的生物碱，具有抗伤害和促进睡眠活性，可有效缓解慢性疼痛。
T3981	Acacetin 4'-Methoxyapigenin,金合欢素,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin	Apoptosis; IAP; COX; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Neuroscience
	Acacetin (5,7-Dihydroxy-4'-methoxyflavone) 是一种来自狗舌草的口服有效类黄酮。它停在 PI3Kγ 的 ATP 结合口袋中，可导致癌细胞周期停滞，并诱导细胞凋亡和自噬。它有抗癌和抗炎活性，有潜力研究疼痛相关疾病。
TN1403	Arjunolic acid	IL Receptor; TNF; Reactive Oxygen Species; JNK; AChE	Apoptosis; Immunology/Inflammation; MAPK; Metabolism; Neuroscience; NF-κB
	Arjunolic acid 是分离自蓝莓的皂苷，具有抗氧化、抗菌和抗炎症等多种生物活性，在保护细胞和组织免受活性氧的有害作用中发挥重要作用。
TN2031	γ-Terpinene Moslene,p-Mentha-1,4-diene,Crithmene	Antioxidant	oxidation-reduction
	γ-Terpinene (p-Mentha-1,4-diene) 是一种单萜化合物，具有高抗氧化属性，适合口服。它展示了直接的自由基清除能力，并且已知是一种有效的抗痛剂。
T4S1990	Carvacrol 香荆芥酚,Karvakrol,O-Thymol,cymophenol,香芹酚	Apoptosis; Others; Gamma-secretase; Endogenous Metabolite; Antifungal	Apoptosis; Metabolism; Microbiology/Virology; Neuroscience; Others; Proteases/Proteasome; Stem Cells
	Carvacrol (O-Thymol) 是唇形科植物中的一种单萜酚类天然产物，具有镇痛、抗焦虑、抗抑郁、抗氧化、抗炎和抗癌作用。
TN1413	Atranorin 荔枝素，巴美灵,荔枝素	Endogenous Metabolite; NO Synthase; Ras	GPCR/G Protein; Immunology/Inflammation; MAPK; Metabolism
	Atranorin 是地衣的次生代谢产物，具有显着的抗伤害、抗炎和氧化还原活性，对 H(2)O(2) 诱导的氧化应激下的细胞具有细胞保护作用。
TN1377	α-Spinasterol Α-波菜甾醇,alpha-Spinasterol,菠甾醇	COX; Antibacterial; TRP/TRPV Channel	Immunology/Inflammation; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	α-Spinasterol 是一种从Spinacia oleracea 分离的瞬时受体电位香草酸 1 拮抗剂，具有抗菌、抗炎、抗抑郁、抗氧化和抗伤害作用。它抑制COX-1和COX-2活性，IC50值分别为 16.17 μM 和 7.76 μM。
T5814	Aurantiamide TMC-58B,橙黄胡椒酰胺	p38 MAPK; NF-κB	MAPK; NF-κB
	Aurantiamide 是马齿苋的活性成分，具有多种生物活性（如抗氧化、抗血小板、抗炎、抗肿瘤活性等），具有口服活性。
TN1712	Gossypin	NF-κB; S6 Kinase	MAPK; NF-κB; PI3K/Akt/mTOR signaling
	Gossypin 是一种从Hibiscus vitifolius 中分离得到的黄酮，能够抑制NF-κB 和 NF-κB 的调节基因表达。在小鼠原代骨髓细胞和 RAW264.7 细胞中，它也可抑制 RANKL 诱导的破骨细胞形成。它具有抗氧化、抗炎、抗癌、抗衰老、抗糖尿病和保护肝脏的活性。
T5S0581	Sec-O-Glucosylhamaudol 亥茅酚苷,Hamaudol 3-glucoside	Others; Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience; Others
	Sec-O-Glucosylhamaudol (Hamaudol 3-glucoside) 是从滨海前胡中分离得到的一种天然产物，能够降低 μ 阿片受体的蛋白水平，可用于缓解疼痛的研究。它通过调节脂多糖刺激的 RAW264.7 细胞系中的 p38 丝裂原活化蛋白激酶具有抗炎作用。
T6S1369	Vitexin 牡荆素,Apigenin-8-C-glucoside	Antioxidant	oxidation-reduction
	Vitexin 是一种存在于多种药用植物（如榕树、螺旋藻）中的 c-糖基化的黄酮。它具有广泛的药理作用，包括抗氧化，抗癌，抗炎，抗痛觉过敏和神经保护作用。
T6S1579	Monotropein 水晶兰苷,Monotropeine	Others	Others
	Monotropein (Monotropeine) 是从Morinda officinalis 中获得，能够抑制硫酸葡聚糖硫酸钠诱导的结肠炎小鼠模型中炎性因子的表达。
T10191L	7-Chlorokynurenic acid 7-chloro-4-hydroxy-2-carboxyquinoline,7-氯犬尿酸,7-CKA	GluR; NMDAR	Neuroscience
	7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) 是一种有效的选择性 NMDA 受体拮抗剂，对甘氨酸 B 激动剂位点的 IC50 为 0.56 μM。 7-Chlorokynurenic acid 抑制谷氨酸再摄取到突触小泡中，Ki 为 0.59 μM，并在神经轴输送后显示出镇痛作用。
T2S2362	Dehydrocorydaline nitrate 去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱	BCL; Others; PARP; p38 MAPK; Caspase; Parasite; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Others; Proteases/Proteasome
	Dehydrocorydaline nitrate 是生物碱。Dehydrocorydaline 调节 Bax，Bcl-2蛋白表达，激活 caspase-7，caspase-8，并使 PARP 失活。它能增强 p38 MAPK 活化，具有抗炎、抗癌、抗疟疾等功效。
T5S2358	Dehydrocorydaline Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine	BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome
	Dehydrocorydaline (13-Methylpalmatine) 是一种生物碱。它调节Bax，Bcl-2蛋白表达，激活caspase-7，caspase-8，并使PARP 失活。它能增强p38 MAPK 活化，具有抗炎、抗癌等功效。它具有强大的抗疟疾作用，并具低细胞毒性。
T2S2264	Linalool Linalol,(±)-Linalool,Phantol,沉香醇	Apoptosis; IL Receptor; TNF; Endogenous Metabolite; iGluR	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Linalool (Linalol) 是存在芫荽等植物中的单萜类天然产物，是竞争性NMDA 受体拮抗剂，具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤，具有镇痛、抗菌和抗炎的特性。
T4S0969	Obtusifolin 决明蒽醌,决明蒽醌；美决明子素	Antioxidant; NF-κB	NF-κB; oxidation-reduction
	Obtusifolin 是分离自决明子的种子中，能够抑制NF-kB 通路，调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。它通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。
T3S2259	Methyl eugenol 4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Methyl eugenol (4-allylveratrole) 是一种苯丙类化合物，存在于植物叶子、果实、根茎中，当植物相应的部位因食草动物进食而受损时，就会释放。它可用于消灭雄性东方果蝇。
TN1059	Ganoderic acid B	IL Receptor; HIV Protease; JAK; STAT	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Proteases/Proteasome; Stem Cells
	Ganoderic acid B 是从灵芝中分离的一种三萜类天然产物。它是端粒酶抑制剂，抑制 Epstein-Barr 病毒抗原的活化。它是 HIV-1 蛋白酶抑制剂。
TN1989	Niga-ichigoside F1 苦莓苷F1	Others; Nrf2	Immunology/Inflammation; Others
	Niga-ichigoside F1(NI) has anti-inflammatory, gastroprotective ,antinociceptive, and cytotoxic effects.
TN4141	Glochidone	Others	Others
	Glochidone shows pronounced antinociceptive properties in mice.
TCS2336	Evodine	P-gp	Membrane transporter/Ion channel; Neuroscience
	Evodine 是吴茱萸中的主要柠檬苦素，是P-gp 有效抑制剂，可通过保留抗氧化剂防御系统，针对谷氨酸诱导的毒性具有保护作用。
TN4777	Physalin G	Others	Others
	Physalin G has antinociceptive property.
TN3476	Baccatin VI	Others	Others
	Baccatin VI 对对苯并醌诱发的腹部收缩具有显著的抗伤害活性。
TN4440	Limonexic acid	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Limonexic acid shows antinociceptive actions , it produces dose-related inhibition of glutamate- and capsaicin-induced pain. Limonexic acid can effectively protect hepatocyte against CCl4-induced injury.
TN4048	Exoticin	Others	Others
	Exoticin shows antinociceptive and neuropharmacological activities, it could be considered as a suitable candidate for the development of analgesic and anxiolytic agents.
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天然产物

7-Methoxyflavone

Cat.No: T7907

Target: Others

Cat.No: T6S1010

Synonym: 槐定碱,别苦参碱

Target: Others

8-Epideoxyloganic acid

Cat.No: T3834

Synonym: 8-表去氧马钱酸

Target: ROS, Immunology/Inflammation related

Cat.No: T7052

Target: Tyrosinase, COX, HDAC, AChR

Cat.No: T3254

Synonym: 植醇,trans-Phytol,(E)-Phytol

Target: Antibacterial, PPAR, Parasite

Cat.No: T6S1653

Synonym: Alibiflorin,芍药内酯苷

Target: Reactive Oxygen Species

Cat.No: T8014

Synonym: 氧化芳樟醇,2-(2-Hydroxy-2-Propyl)-5-Methyl-5-Vinyltetrahydrofuran

Target: Others

Cat.No: T5S2360

Synonym: Corydalin,紫堇碱,延胡索甲素,(+)-Corydaline

Target: P450, Virus Protease, Opioid Receptor, AChE

Cat.No: T0437

Synonym: INO 495,NSC 20262,肌苷

Target: ROS, Endogenous Metabolite, Adenosine Receptor

Cat.No: T5S1882

Synonym: 准葛尔乌头碱,Napellonine,Zongorine,Bullatine G

Target: Others, GABA Receptor

Cat.No: T8193

Synonym: Thujone,ALPHA-(-)-THUJONE,α-侧柏酮,(-)-α-侧柏酮

Target: Apoptosis, Reactive Oxygen Species, GABA Receptor, AChR, Parasite, Autophagy

Ganoderic acid C6

Cat.No: T5S1131

Synonym: 灵芝酸C6

Target: Others

Cat.No: T6S0743

Target: Others

Dicentrine, (-)-

Cat.No: T20225

Synonym: L-Dicentrine,荷包牡丹碱,NSC 251699,NSC251699,NSC-251699

Target: Others

Cat.No: T5783

Synonym: 野蔷薇苷,罗莎白素

Target: Antioxidant, HIV Protease

1-Hydroxybaccatin I

Cat.No: TN2540

Target: Others

Cat.No: TN1027

Synonym: β-香树脂醇,beta-Amyrin

Target: Beta Amyloid

ANTHRAQUINONE-2-CARBOXYLIC ACID

Cat.No: T7035

Target: IRAK, Syk

Cat.No: T4833

Synonym: N-乙酰-DL-色氨酸,N-Acetyl-DL-tryptophan

Target: Others, Endogenous Metabolite

Kaempferol 3-O-β-D-galactopyranoside

Cat.No: TN1823

Synonym: Kaempferol 3-O-beta-D-galactoside,Kaempferol-3-O-galactoside,三叶豆苷

Target: Immunology/Inflammation related

Cat.No: T8169

Target: Others

Cat.No: T2757

Synonym: 杨梅苷,Myricetrin,Myricitrine

Target: PKC

Cat.No: T6S0627

Synonym: 新乌碱,新乌头碱；中乌头碱

Target: TNF

Cat.No: T3409

Synonym: Y0160,C10485,大车前苷,车前子甙

Target: Others

Cat.No: T5S0662

Synonym: 钩吻碱,Gelsemin

Target: Antioxidant

Cat.No: T3981

Synonym: 4'-Methoxyapigenin,金合欢素,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin

Target: Apoptosis, IAP, COX, Autophagy

Cat.No: TN1403

Target: IL Receptor, TNF, Reactive Oxygen Species, JNK, AChE

Cat.No: TN2031

Synonym: Moslene,p-Mentha-1,4-diene,Crithmene

Target: Antioxidant

Cat.No: T4S1990

Synonym: 香荆芥酚,Karvakrol,O-Thymol,cymophenol,香芹酚

Target: Apoptosis, Others, Gamma-secretase, Endogenous Metabolite, Antifungal

Cat.No: TN1413

Synonym: 荔枝素，巴美灵,荔枝素

Target: Endogenous Metabolite, NO Synthase, Ras

Cat.No: TN1377

Synonym: Α-波菜甾醇,alpha-Spinasterol,菠甾醇

Target: COX, Antibacterial, TRP/TRPV Channel

Cat.No: T5814

Synonym: TMC-58B,橙黄胡椒酰胺

Target: p38 MAPK, NF-κB

Cat.No: TN1712

Target: NF-κB, S6 Kinase

Sec-O-Glucosylhamaudol

Cat.No: T5S0581

Synonym: 亥茅酚苷,Hamaudol 3-glucoside

Target: Others, Opioid Receptor

Cat.No: T6S1369

Synonym: 牡荆素,Apigenin-8-C-glucoside

Target: Antioxidant

Cat.No: T6S1579

Synonym: 水晶兰苷,Monotropeine

Target: Others

7-Chlorokynurenic acid

Cat.No: T10191L

Synonym: 7-chloro-4-hydroxy-2-carboxyquinoline,7-氯犬尿酸,7-CKA

Target: GluR, NMDAR

Dehydrocorydaline nitrate

Cat.No: T2S2362

Synonym: 去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱

Target: BCL, Others, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Dehydrocorydaline

Cat.No: T5S2358

Synonym: Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Cat.No: T2S2264

Synonym: Linalol,(±)-Linalool,Phantol,沉香醇

Target: Apoptosis, IL Receptor, TNF, Endogenous Metabolite, iGluR

Cat.No: T4S0969

Synonym: 决明蒽醌,决明蒽醌；美决明子素

Target: Antioxidant, NF-κB

Cat.No: T3S2259

Synonym: 4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚

Target: GABA Receptor

Ganoderic acid B

Cat.No: TN1059

Target: IL Receptor, HIV Protease, JAK, STAT

Niga-ichigoside F1

Cat.No: TN1989

Synonym: 苦莓苷F1

Target: Others, Nrf2

Cat.No: TN4141

Target: Others

Cat.No: TCS2336

Target: P-gp

Cat.No: TN4777

Target: Others

Cat.No: TN3476

Target: Others

Cat.No: TN4440

Target: GABA Receptor

Cat.No: TN4048

Target: Others

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