397
43
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16545 |
Pivanex
Pivalyloxymethyl butyrate,AN-9 |
Apoptosis; HDAC; Bcr-Abl | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Tyrosine Kinase/Adaptors |
Pivanex (Pivalyloxymethyl butyrate) 是丁酸的一种衍生物,是具有口服活性的 HDAC 抑制剂。Pivanex 通过下调 bcr-abl 蛋白增强凋亡。Pivanex 显示出抗转移和抗血管生成的活性。 | |||
T8310 |
MMP-9-IN-1
|
MMP | Proteases/Proteasome |
MMP-9-IN-1 是特异性的基质金属蛋白酶-9 抑制剂,选择性靶向 MMP-9 的血红素域,对其他 MMP 无影响。 | |||
T39669 |
TLR7/8/9-IN-1
TLR7/8/9-IN-1 |
TLR | Immunology/Inflammation |
TLR7/8/9-IN-1 是具有口服活性的Toll 样受体7/8/9小分子拮抗剂,IC50为43 nM。 | |||
T20388 |
9-Ethylcarbazole
N-乙基咔唑,NSC60585,N-Ethylcarbazole,NSC-60585,NSC 60585 |
Others | Others |
9-Ethylcarbazole (NSC-60585) 是一种生化剂。 | |||
T62515 |
SIRT2-IN-9
|
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
SIRT2-IN-9 是一种具有选择性的SRIT2抑制剂,IC50值为 1.3 μM。SIRT2-IN-9对MCF-7 乳腺癌细胞的增殖有抑制作用。SIRT2-IN-9 可用于研究癌症。 | |||
T35333 |
ARRY-382
|
CSF-1R | Tyrosine Kinase/Adaptors |
ARRY-382 是一种高度选择性的 CSF-1R 口服抑制剂,IC50 为 9 nM。 | |||
T77617 |
MMP-9-IN-6
|
MMP | Proteases/Proteasome |
MMP-9-IN-6 是一种 MMP-9 抑制剂,其 IC50 值为50 μM, 具有较好的抗溃疡功效。MMP-9-IN-6 具有潜在的抗肿瘤活性,可用于研究组织重塑、伤口修复和动脉粥样硬化。 | |||
T15388 |
GLPG0974
GLPG-0974 |
GPR | Endocrinology/Hormones; GPCR/G Protein |
GLPG0974 是 FFA2/GPR43 的拮抗剂,IC50 为 9 nM。 | |||
T77494 |
TNF-α-IN-9
|
TNF | Apoptosis |
TNF-α-IN-9 是一种 NDM-1 inhibitor-3类似物,是一种 TNF-α 抑制剂。TNF-α-IN-9 显示低抑制活性。 | |||
T9579L |
GLP-1 receptor agonist 9 citrate
GLP-1 receptor agonist 9 citrate (2401892-71-3 Free base) |
Glucagon Receptor | GPCR/G Protein |
GLP-1 receptor agonist 9 citrate 是 GLP-1 的激动剂。 | |||
T6556 |
K-Ras(G12C) inhibitor 9
|
Raf | MAPK |
K-Ras(G12C) inhibitor 9 是致癌 K-Ras(G12C) 的变构抑制剂。 | |||
TQ0132 |
A 419259 trihydrochloride
RK 20449 trihydrochloride |
Src | Angiogenesis; Tyrosine Kinase/Adaptors |
A 419259 trihydrochloride (RK 20449 trihydrochloride) 是一种 Src 家族激酶抑制剂,能够抑制 Src (IC50:9 nM)、Lck (IC50:3 nM)、Lyn (IC50:3 nM)。 | |||
T15665 |
KJ Pyr 9
|
c-Myc; Autophagy | Autophagy; Cell Cycle/Checkpoint |
KJ Pyr 9 是一种 MYC 的抑制剂,在体外实验中的 Kd 值为 6.5 nM。 | |||
T8321 |
10-methyl-9-(phenoxycarbonyl) Acridinium
|
Others | Others |
10-methyl-9-(phenoxycarbonyl) Acridinium 是一种吖啶鎓酯,在碱性条件下与过氧化氢、过硫酸盐和其他氧化剂氧化后会产生荧光 10-methyl-9-acridone。 | |||
T4211 |
SAG hydrochloride (912545-86-9(free base))
Smoothened Agonist HCl |
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) 可作为 SMO 激动剂。 | |||
TNU0266 |
9-(β-D-Xylofuranosyl)adenine
Xylosyladenine,Adenine xyloside |
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
9-(β-D-Xylofuranosyl)adenine (Adenine xyloside) 是一种腺嘌呤核苷类似物,是一种潜在的平滑肌血管扩张剂。9-(β-D-Xylofuranosyl)adenine 具有抗癌活性。 | |||
TP1079 |
(Arg)9 TFA (143413-47-2 free base)
Nona-L-arginine (TFA),(Arg)9 TFA,Peptide R9 (TFA) |
Others | Others |
(Arg)9 TFA (Peptide R9 TFA) 是一种可渗透细胞的多肽,在谷氨酸模型实验模型中保护神经(IC50:0.78 μM)。 | |||
T10953 |
Dafadine-A
|
P450 | Metabolism |
Dafadine-A 是dafadine 的类似物,是C. elegans DAF-9 细胞色素P450抑制剂,同时对哺乳动物的CYP27A1具有抑制作用。 | |||
T28178 |
NLRP3-IN-9
INF-4E,INF 4E,INF4E |
NOD | Immunology/Inflammation; NF-κB |
NLRP3-IN-9 (INF-4E) 是 NLRP3 ATPase 和 caspase-1 的抑制剂。 NLRP3-IN-9 通过不可逆地捕获硫醇亲核体发挥作用,以时间和浓度依赖性方式防止 ATP 和尼日利亚菌素触发的人 THP-1 细胞焦亡。 | |||
T63055 |
RIPK1-IN-9
|
RIP kinase | Apoptosis; NF-κB |
RIPK1-IN-9是是一种强效且具有选择性的 RIPK1抑制剂,是一种二氢萘酮化合物。RIPK1-IN-9对 U937细胞和 L929细胞具有抑制作用,IC50分别为2 nM 和1.3 nM。 | |||
T63896 |
BE1218
|
Liver X Receptor | Metabolism |
BE1218 是一种肝 X 受体 (LXR) 反向激动剂,对 LXRα 和 LXRβ有活性,IC50 分别为 9 nM 和 7 nM。 | |||
T26252 |
PI3Kδ-IN-3
TC KHNS 11 |
PI3K | PI3K/Akt/mTOR signaling |
PI3Kδ-IN-3 (TC KHNS 11) 是一种 PI3Kδ 抑制剂,IC50 值为 9 nM。PI3Kδ-IN-3 具有良好的药代动力学特性且对 B 细胞功能有抑制作用。 | |||
TP2252 |
GLP-1 (9-36) amide
|
Glucagon Receptor | GPCR/G Protein |
GLP-1(9-36)amide 是胰高血糖素样肽-1 (7-36) amide 的主要代谢产物,对人胰腺 GLP-1受体具有拮抗作用。 | |||
T21512 |
MMP-2/MMP-9 Inhibitor I
|
MMP | Proteases/Proteasome |
MMP-2/MMP-9-IN-1 是一种有效的、具有高选择性和可口服的 IV 型胶原酶 (MMP-9和MMP-2) 抑制剂,对 MMP-9 和 MMP-2具有抑制作用, IC50分别为 0.24 和 0.3 1μM。MMP-2/MMP-9-IN-1 在肿瘤生长和转移的动物模型中展现出口服活性,可用于研究癌症。 | |||
T29652 |
9-Cyclopentyladenine
NSC19486,NSC 19486,9CPAde,9-CP-Ade,9 CP Ade,NSC-19486 |
AChR | Neuroscience |
9-Cyclopentyladenine (NSC-19486) 是一种腺苷酸环化酶抑制剂,可阻断细胞形态分化和特定信号分子磷酸化。 | |||
T6037 |
E-64
Proteinase inhibitor E 64,E 64,E64 |
Cysteine Protease; Antibacterial; Autophagy | Autophagy; Microbiology/Virology; Proteases/Proteasome |
E-64 (Proteinase inhibitor E 64)是一种不可逆的半胱氨酸蛋白酶抑制剂,抑制papain 的IC50为 9 nM。 | |||
T15675 |
Tirbanibulin Mesylate
KX2-391 Mesylate,KX01 Mesylate |
Microtubule Associated; Src | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Tirbanibulin Mesylate (KX01 Mesylate) 是一种 Src 抑制剂,靶向 Src 的肽底物位点。在肿瘤细胞中,GI50值为 9-60 nM。 | |||
T22700 |
Cyclapolin 9
|
PLK | Cell Cycle/Checkpoint |
Cyclapolin 9 是一种具有选择性、有效性和 ATP 竞争性的 polo-like kinase 1 (PLK1) 抑制剂,IC50 为 500 nM,对其他激酶尚未显示出活性。 | |||
T7354 |
H-Val-Pro-Pro-OH
|
RAAS | Endocrinology/Hormones |
H-Val-Pro-Pro-OH 是一种血管紧张素 I 转化酶(ACE)的抑制剂(IC50:9 μM)。他是一种来源于牛奶的脯氨酸肽衍生物。 | |||
T16940 |
STAT5-IN-2
|
Apoptosis; STAT | Apoptosis; JAK/STAT signaling; Stem Cells |
STAT5-IN-2 是一种具有抗白血病作用的 STAT5 抑制剂(EC50:在 K562 和 KU812 细胞中分别为 9 μM 和 5 μM)。 | |||
T7566L |
GRGDSPK 2TFA(111119-28-9(free base))
EMD 56574 |
Others | Others |
GRGDSPK 2TFA(111119-28-9(free base)) (EMD 56574) 是一种抑制肽,用于 RGD 介导的整合素和细胞外基质分子之间的粘附。 | |||
TP1181 |
Bradykinin (2-9)
Des-Arg1-bradykinin |
Bradykinin Receptor | GPCR/G Protein |
Bradykinin (2-9) (Des-Arg1-bradykinin),是Bradykinin的一种氨基端截短肽类代谢物,通过Aminopeptidase P的切割作用形成。 | |||
TP1348 |
FC131 TFA (606968-52-9 free base)
FC131 TFA |
HIV Protease; CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
FC131 TFA (606968-52-9 free base) (FC131 TFA) 是 CXCR4 的拮抗剂,可抑制 [125I] -sdf-1 与 CXCR4 的结合(IC50:4.5 nM),并具有抗 HIV 活性。 | |||
T11526 |
DPP-IV-IN-2
H-Lys(4-nitro-Z)-pyrrolidide |
DPP-4 | Proteases/Proteasome |
DPP-IV-IN-2 (H-Lys(4-nitro-Z)-pyrrolidide) 是二肽基肽酶 IV 和DP8/9的抑制剂, IC50分别为 0.1 和 0.95 μM。 | |||
T23286 |
S 24795
Catestatin acetate(142211-96-9 free base),LNAChR |
AChR | Neuroscience |
S 24795 (Catestatin acetate(142211-96-9 free base)) 是一种 α7 nAChR 部分激动剂。 S 24795 改善了老年小鼠的记忆功能,可用于与衰老相关的记忆障碍的研究。 | |||
T4650 |
C188-9
TTI-101 |
Apoptosis; STAT | Apoptosis; JAK/STAT signaling; Stem Cells |
C188-9 (TTI-101) 是一种Stat3抑制剂,其Kd 值为 4.7 nM。它诱导 AML 细胞系和原代标本凋亡,抑制原代 AML 细胞集落形成。它抑制 G-CSF 诱导的 STAT3 激活和 STAT3 依赖性基因表达。 | |||
T9650 |
AZ12672857
|
Src; Ephrin Receptor | Angiogenesis; Tyrosine Kinase/Adaptors |
AZ12672857 是一种 EphB4 抑制剂,IC50 为 1.3 nM。 AZ12672857 抑制 Src 转染 3T3 细胞的细胞增殖,IC50 为 2 nM,抑制转染 CHO-K1 细胞中 EphB4 的自磷酸化,IC50 为 9 nM。 | |||
TP1865L |
Rhodopsin Epitope Tag acetate
|
Others | Others |
Rhodopsin Epitope Tag acetate 是一种 9 个氨基酸的肽,代表牛视紫红质的 C 末端,广泛用作表位标签。许多抗视紫红质抗体可以识别该表位。 | |||
T16886 |
Sinefungin
Adenosyl-Ornithine,西奈芬净,A-9145,Antibiotic 32232RP |
Others; Histone Methyltransferase; Antibiotic; Antifungal | Chromatin/Epigenetic; Microbiology/Virology; Others |
Sinefungin (Adenosyl-Ornithine) 是病毒粒子mRNA (鸟嘌呤-7-)-甲基转移酶、 mRNA (核苷-2'-)-甲基转移酶和病毒增殖的有效抑制剂。它还抑制SET7/9,通过抑制H3K4甲基化来改善肾纤维化。 | |||
T15017 |
CU-T12-9
|
TLR | Immunology/Inflammation |
CU-T12-9 是特异性 TLR1/2激动剂,可激活先天免疫系统和适应性免疫系统。它选择性激活 TLR1/2 异二聚体,可通过促进 TLR1 和 TLR2 二聚而激活 NF-κB 信号,引起下游 TNF-α、IL-10 和 iNOS 增加。 | |||
TQ0090 |
Nesbuvir
HCV-796 |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Nesbuvir 是一种选择性丙型肝炎病毒(HCV)非结构蛋白5B(NS5B)RNA 依赖性聚合酶抑制剂。Nesbuvir 对含1b HCV 复制子的肝癌细胞的 IC50为9nM。 | |||
T8372 |
VU0134992
VU 0134992 |
Potassium Channel | Membrane transporter/Ion channel |
VU 0134992 是一个亚型偏好的,口服有效的和选择性的内向整流钾通道 Kir4.1阻滞剂,IC50为 0.97 μM。在 -120 mV 时,VU0134992对同分 Kir4.1 比 Kir4.1/5.1 共分通道 (IC50=9 μM) 高出 9 倍的选择性。 | |||
T9651 |
PD-1/PD-L1-IN-9
|
PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
PD-1/PD-L1-IN-9 是一种有效和具有口服活性的 PD-1/PD-L1 相互作用抑制剂,IC50 值为 3.8 nM。PD-1/PD-L1-IN-9 可以增强免疫细胞对肿瘤细胞的杀伤活性。PD-1/PD-L1-IN-9 在 CT26 小鼠模型中表现出显着的体内抗肿瘤活性。 | |||
T3990 |
AA26-9
|
Phospholipase; Serine Protease | Metabolism; Proteases/Proteasome |
AA26-9 是广谱丝氨酸水解酶的高效抑制剂。它的靶点包括丝氨酸肽酶、酰胺酶、脂肪酶、酯酶和硫酯酶。在永生化 T 细胞系,检测到它对 40+ 丝氨酸水解酶中的 1/3 有抑制作用。 | |||
T16491 |
PF-06446846 hydrochloride
|
Others | Others |
PF-06446846 hydrochloride 是一种口服活性高、高选择性PCSK9(前蛋白转化酶枯草杆菌蛋白酶/kexin 9 型)翻译抑制剂。它通过在密码子34附近诱导核糖体暂停来抑制PCSK9。 | |||
TP1204 |
iRGD peptide
c(CRGDKGPDC) |
Integrin | Cytoskeletal Signaling |
iRGD peptide (c(CRGDKGPDC)) 是由 9 个氨基酸组成的环肽,具有靶向肿瘤和肿瘤渗透的作用。 | |||
T9642 |
ZW4864 free base
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
ZW4864 free base 是口服有效的,选择性的 β catenin/ B-Cell lymphoma 9 蛋白-蛋白相互作用 (β catenin/BCL9 PPI) 抑制剂 (Ki= 0.76 μM, IC50= 0.87 μM)。 | |||
T12225L |
Nevanimibe hydrochloride
PD-132301 hydrochloride,ATR101 hydrochloride |
Apoptosis; Acyltransferase | Apoptosis; Metabolism |
Nevanimibe hydrochloride (PD-132301 hydrochloride) 是一种口服有效的,选择性酰基辅酶 A:胆固醇 O-酰基转移酶 1 抑制剂,EC50为 9 nM。它抑制 ACAT2,EC50为 368 nM。它诱导细胞凋亡,具有抗肾上腺皮质癌的潜力。 | |||
T18910 |
Acid Yellow 9 monosodium salt
Hydrogen 4-aminoazobenzene-3,4'-disulphonate (sodium salt) |
Others | Others |
Acid Yellow 9 monosodium salt (Hydrogen 4-aminoazobenzene-3,4'-disulphonate (sodium salt)) 是一种可被Pseudomonas fluorescens 降解的含氮染料,是此类菌株碳、氮和能量的唯一来源。 | |||
TQ0174 |
Mavorixafor
AMD-070 |
CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
Mavorixafor (AMD-070) 是一种有效的特异性 CXCR4 拮抗剂,对 CXCR4 125I-SDF 结合的 IC50 值为 13 nM。 Mavorixafor 在 MT-4 细胞 (IC50 = 1 nM) 和 PBMC (IC50 = 9 nM) 中抑制 T-tropic HIV-1 (NL4.3 株) 的复制。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5132 |
9-dihydro-13-acetylbaccatin III
13-乙酰基-9-羟基巴卡丁 III,13-Acetyl-9-dihydrobaccatin III,9-DHAB III |
Apoptosis | Apoptosis |
9-dihydro-13-acetylbaccatin III (9-DHAB III) 是一种制备紫杉醇类似物的中间体。 | |||
T3801 |
(Rac)-Byakangelicin
白当归素,Bjacangelicin,Bjakangelicin,Biacangelicin,7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-,Byakangelicin |
Others | Others |
(Rac)-Byakangelicin (7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-) 是一种 Byakangelicin 的外消旋体,主要分离自 Angelica 属中。其中 Byakangelicin 是醛糖还原酶抑制剂(IC50:6.2 μM),可用作抗肿瘤剂。 | |||
T3S1957 |
9-amino-CPT
9-氨基喜树碱,Aminocamptothecin,9-amino-2(S)-camptothecin,9-Aminocamptothecin |
Topoisomerase | DNA Damage/DNA Repair |
9-amino-CPT (Aminocamptothecin) 是一种拓扑异构酶I 的抑制剂,具有抗肿瘤活性。 | |||
TQ0296L |
N-Nornuciferine hydrochloride(4846-19-9 free base)
N-Nornuciferine hydrochloride |
P450 | Metabolism |
N-Nornuciferine hydrochloride(4846-19-9 free base) (N-Nornuciferine hydrochloride) 是荷叶中的一种 aporphine 生物碱,显着抑制 CYP2D6(IC50:3.76 μM,Ki:2.34 μM)。 | |||
T4872 |
Palmitoleic acid
棕榈油酸,(Z)-Hexadec-9-enoic acid,(Z)-9-hexadecenoic acid |
Endogenous Metabolite | Metabolism |
Palmitoleic acid ((Z)-Hexadec-9-enoic acid) 是脂肪酸的组成部分,能够预防 SHRSP 大鼠因脑血管疾病引起的死亡。 | |||
T36390 |
Sodium oleate
Oleic acid sodium salt,Sodium oleate,cis-9-Octadecenoic acid sodium salt |
ATPase | Membrane transporter/Ion channel |
Sodium oleate (cis-9-Octadecenoic acid sodium salt) (Oleic acid sodium) 是人脂肪细胞和其他组织中最常见的单不饱和脂肪酸钠盐。Sodium oleate 是一种 Na+/K+ ATP 酶激活剂。 | |||
T4811 |
D-Alanine
D-α-Alanine,Ba 2776,(R)-Alanine,D-丙氨酸,(R)-2-Aminopropionic acid |
Chloride channel; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism |
D-Alanine ((R)-Alanine) 是一种GlyR 和PMBA 的弱激动剂,其对GlyR 的EC50=9 mM。 | |||
T36831 |
9-Oxononanoic Acid
9-ONA |
Phospholipase; CPT | Metabolism |
9-Oxononanoic Acid是一种氧化脂肪酸,由亚油酸自氧化形成,它能提高磷脂酶 A2(PLA2)的活性,并增加离体人体血浆中血栓素 B2 的生成。9-Oxononanoic Acid 能减少肝脏新脂肪酸的合成,并提高大鼠肝脏肉碱棕榈酰转移酶(β-氧化的标志物)的活性。 | |||
T36473 |
trans-Nerolidol
|
||
trans-Nerolidol is a sesquiterpene that has been found in various plants, includingC. sativa, and has diverse biological activities, including antimicrobial, antioxidant, anticancer, and insecticidal properties.1,2,3,4In a disc assay,trans-nerolidol inhibits the growth ofS. aureus,B. subtilis,E. coli, andS. cerevisiaewith zones of inhibition measuring 10, 9, 10, and 4 mm, respectively.2It reduces viability of CaCo-2 adenocarcinoma cells with an IC50value of 28.7 mg/L and reduces production of re... | |||
T0076 |
Paliperidone
9-羟基利培酮,帕潘立酮,9-hydroxyrisperidone |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Paliperidone (9-hydroxyrisperidone) 是 Risperidone 的主要活性代谢产物,是多巴胺 D2 拮抗剂和5-HT2A 拮抗剂。它用作非典型抗精神病药,用于精神分裂症的急性及维持治疗。它对α1和α2肾上腺素能受体和 H1组胺能受体也有拮抗作用。 | |||
T2959 |
Ginsenoside Rh2
20(S)-Rh2,20S-Ginsenoside Rh2,人参皂苷Rh2,20(S)-Ginsenoside Rh2,人参皂苷 Rh2 |
Apoptosis; EGFR; Caspase; Endogenous Metabolite | Angiogenesis; Apoptosis; JAK/STAT signaling; Metabolism; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Ginsenoside Rh2 (20(S)-Ginsenoside Rh2) 诱导caspase-8和caspase-9活化。它以多途径方式诱导癌细胞凋亡。 | |||
T5242 |
Triarachidin
Triarachin,1,2,3-Trieicosanoyl Glycerol,Glycerol Trieicosanoate,三花生精 |
Others; Endogenous Metabolite | Metabolism; Others |
Triarachidin (1,2,3-Trieicosanoyl Glycerol) 是内源性代谢产物的一种。 | |||
T7126 |
Hydroquinine
氢化奎宁,dihydroquinine |
Others | Others |
Hydroquinine 是金鸡纳生物碱,可用于制备衍生物(如 C9 脱氢喹啉、9-乙酰氧基-10,11-二氢喹、 10,11-二氢喹单盐酸盐等)。 | |||
TN6909 |
Polyporusterone B
猪苓酮B,(1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one |
Others | Others |
Polyporusterone B ((1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one) 是一种三萜羧酸,从Polyporus umbellatusFries 中分离得到。它对自由基诱导的红细胞裂解 (溶血) 具有抑制作用。 | |||
T5S2059 |
Glaucine
|
Calcium Channel; Dopamine Receptor; Influenza Virus; Adrenergic Receptor; PDE | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience |
Glaucine 是从海罂粟中分离的一种生物碱,具有镇咳、抗炎和支气管扩张作用。它是具有口服活性的磷酸二酯酶 4 选择性抑制剂。它还是非选择性的 α-肾上腺素受体拮抗剂,具有抗氧化和抗病毒活性。 | |||
T3729 |
Ethyl gallate
Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯 |
MMP; NF-κB; Akt; Antibacterial | Cytoskeletal Signaling; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Ethyl gallate (gallic acid ethyl ester) 是一种非类黄酮酚过氧化氢清除剂。 | |||
T2973 |
Astragaloside IV
AST-IV,黄芪甲苷IV,AS-IV,黄芪皂苷 IV |
MMP; ERK; Estrogen/progestogen Receptor; JNK | Endocrinology/Hormones; MAPK; Proteases/Proteasome |
Astragaloside IV (AS-IV) 是从黄芪中分离得到的一种皂苷,抑制ERK1/2和JNK 激活,在乳腺癌细胞 MDA-MB-231 中,下调(MMP)-2和(MMP)-9的信号通路。 | |||
T4944 |
Nervonic acid
cis-15-Tetracosenoic acid,神经酸,Selacholeic acid |
Endogenous Metabolite | Metabolism |
Nervonic acid (Selacholeic acid) 是在髓磷脂生物合成中很重要的单不饱和脂肪酸。 | |||
T36914 |
2-Hydroxyanthraquinone
|
Others | Others |
2-Hydroxyanthraquinone 是一种天然产物,显示出抗肿瘤和免疫抑制活性。 | |||
T6485 |
Embelin
NSC 91874,恩贝酸,恩贝酸/恩贝灵,Emberine,Embelic acid |
Apoptosis; NF-κB; Lipoxygenase; IAP; Prostaglandin Receptor; Autophagy | Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism; NF-κB |
Embelin (Embelic acid) 是从日本 Ardisia 草药中分离出来的一种非肽类细胞渗透性XIAP 抑制剂,诱导口腔鳞癌细胞自噬和凋亡。它阻断 NF-kappaB 信号通路,从而抑制 NF-kappaB 调节的抗凋亡和转移基因产物。在高水平 XIAP 的前列腺癌细胞中抑制细胞生长,诱导凋亡,并激活 caspase-9。 | |||
T75545 | PCSK9-IN-9 | ||
PCSK9-IN-9 是一种天然来源的异香豆素。PCSK9-IN-9 可抑制原蛋白转化酶枯草菌素 kexin 型 9 (PCSK9)、IDOL 和 SREBP2的 mRNA 表达水平。PCSK9-IN-9 抑制 PCSK9的 IC50为 11.9 μM。 | |||
T81903 |
Lupulone C
|
||
Lupulone C (Compound 9)为一种抑制NO生成的化合物。 | |||
T83062 | Anti-inflammatory agent 28 | ||
Compound 9 (Anti-inflammatory agent 28) 是一种具备肝脏保护活性的抗炎剂。 | |||
T83228 |
9-O-Methylstecepharine
|
||
9-O-Methylstecepharine(化合物 7)为Stephania cepharantha中检出的生物碱。 | |||
T39460 |
Mead acid
5,8,11-Eicosatrienoic acid |
||
Mead acid, also known as 5,8,11-Eicosatrienoic acid, is an unsaturated fatty acid belonging to the Omega-9 series. It serves as an indicator of deficiency in essential fatty acids. | |||
T82555 | Dihydrodehydrodiconiferyl alcohol 9-Oglucoside | ||
Dihydrodehydrodiconiferyl alcohol 9-O-β-D-glucopyranoside (DHD) is an extractable compound from G. mangostana L. | |||
T83447 |
15-Nor-14-oxolabda-8(17),12E-Diene-18-oic acid
|
||
15-Nor-14-oxolabda-8(17),12E-Diene-18-oic acid (compound 9) 为从Chloranthus spicatus提取的化学化合物。 | |||
T10044 | 13-Oxo-9E,11E-octadecadienoic acid | PPAR | DNA Damage/DNA Repair; Metabolism |
13-Oxo-9E,11E-octadecadienoic acid, a potent PPARα activator derived from tomato juice and an isomer of 9-oxo-ODA, exhibits the ability to decrease plasma and hepatic triglyceride levels in obese diabetic mice[1]. | |||
T75505 | Xanthine oxidase-IN-9 | ||
Xanthine oxidase-IN-9 (Icarisids E) (Compound 2),一种黄嘌呤氧化酶 (XOD) 高效抑制剂,具有31.81 μM 的 IC50 值。 | |||
T2O2667 |
Methyl Oleate
油酸甲酯,oleic acid methyl ester,Methyl cis-9-Octadecenoate,cis-9-Octadecenoic Acid methyl ester |
Others | Others |
Methyl Oleate (cis-9-Octadecenoic Acid methyl ester) 是脂肪酸甲酯。它能够显著提高抗氧化能力,但也明显削弱二烷基二硫代磷酸锌的抗磨能力。 | |||
T80332 |
Maximin H1
|
||
Maximin H1是一种抗菌肽,由中华红腹蟾蜍(Bombina maxima)皮肤分泌物提取得到。该化合物对Escherichia coli ATCC 25922、Staphylococcus aureus ATCC 25923、Bacillus pyocyaneus CMCC B1010和Candida albicans ATCC 2002表现出抗菌活性,其最小抑菌浓度(MIC)值分别为9、4.5、9、4.5 μg/ml。 | |||
T41253 |
Sterculic acid
|
||
Sterculic acid 是一种硬脂酰辅酶 A 去饱和酶 1 (SCD1) 抑制剂。Sterculic acid 剂量依赖性抑制 delta-9 去饱和酶 (Δ9D) 活性,IC50值为 0.9 μM。 | |||
T16397 |
Ophiobolin A
|
Others | Others |
Ophiobolin A is a fungal metabolite and a phytotoxin and is an effective and irreversibly inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase (IC50: 9 μM). Ophiobolin A also has antimicrobial and anticancer activity. | |||
TN2728 |
Jatrophane 4
|
Antifection | Microbiology/Virology |
Jatrophane 3 (2R*,3R*, 4S*,5R*,7S*,8S*,9S*,l3S*,14S*,15R*)-2,5,14-triacetoxy-3-benzoyloxy-8,15-dihydroxy-7-isobutyroyloxy-9-nicotinoyloxyjatropha-6(17),11E-diene) exhibits significant antifeedant activity against a generalist plant-feeding insect, the cotton bollworm (Helicoverpa armigera), with an EC50 value of 0.43 ug/cm2. | |||
T79975 |
Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside
|
HBV | Microbiology/Virology |
Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside(化合物1)是一种具有抗HBV活性的木脂素类化合物。该化合物对HBV表面抗原(HBsAg)的IC50为0.58 mM,而对HBV e抗原(HBeAg)的IC50 > 2.4 mM。其可从八角茴香中提取分离。 | |||
T73403 |
Aviculin
|
||
Aviculin 是一种木聚糖苷,是一种有效的抗癌剂 (anticanceragent)。Aviculin 可降低 MCF-7 细胞代谢活性到 50% 以下,IC50为 75.47 μM。Aviculin 通过内在凋亡途径诱导乳腺癌细胞凋亡 (apoptosis)。Aviculin 增加了 caspase-9、caspase-7和 PARP 的表达。Aviculin 使 Bax/Bcl-2 的比值升高。 | |||
T79976 |
Dihydrodehydrodiconiferyl alcohol 9-O-β-D-xylopyranoside
|
HBV | Microbiology/Virology |
Dihydrodehydrodiconiferyl alcohol 9-O-β-D-xylopyranoside 作为一种抗HBV剂,在Hep G2.2.15细胞系上能够抑制HBsAg和HBeAg的分泌,其IC50值分别约为1.67 mM和>2.15 mM。 | |||
T14121 |
Actinonin
(-)-Actinonin |
Aminopeptidase | Metabolism |
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM, it also is an apoptosis inducer. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase, it also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5]. | |||
T81958 |
Lacto-N-neodifucohexaose II
LNnDFH II |
||
Lacto-N-neodifucohexaose II(Compd 9),一种关键的人乳四糖衍生物,为点击化学反应试剂。该化合物含 Azide 基团,适用于铜催化叠氮-炔环加成反应(CuAAc),与含 Alkyne 基团的分子反应。同时,它也能与含 DBCO 或 BCN 基团的分子,进行菌株促进的炔-叠氮环加成反应(SPAAC)。 | |||
T5157 |
9,13-Epidioxy-8(14)-abieten-18-oic acid
|
Others | Others |
9,13β-Epidioxy-8(14)-abieten-18-oic acid has anti-inflammatory activities, it exhibits moderate activities on NO levels in LPS-stimulated murine microglia BV2 cells, with IC50 values of 57.3 ± 0.2 uM. It is also a potential antitumor-promoting diterpenoid, it shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate. 9 α ,13 β -Epidioxyabeit-8(14)en-18-oic acid may contribute to the growth inhibitory... | |||
T36438 |
Sporogen-AO 1
|
||
Sporogen-AO 1 is a fungal metabolite originally isolated fromA. oryzaethat has diverse biological activities.1,2,3,4,5It inhibits HIV-1 Tat transactivation in a cell-based assay with an IC50value of 15.8 μM.4Sporogen-AO 1 is cytotoxic to HeLa, KB, and NCI H187 cancer cells (IC50s = 8.3, 9, and 5.1 μM, respectively).2,5It is active againstC. albicans(MIC = 4 mM).3 1.Tanaka, S., Wada, K., Marumo, S., et al.Structure of sporogen-ao 1, a sporogenic substance of Aspergillus oryzaeTetrahedron Lett.25(... | |||
T36348 |
Cerebroside C
|
||
Cerebroside C is a fungal metabolite and glycosphingolipid that has been found in the rice pathogenic fungusM. grisea.1It induces production of the phytoalexin momilactone A when applied to wounded rice leaves, indicating that cerebroside C is an elicitor of the hypersensitive response in rice. Cerebroside C increases germination rate and reduces germination time in wheat seeds in a concentration-dependent manner at 4°C.2It also increases root length, fresh weight, and dry weight of wheat seedli... | |||
T36954 |
Nemorosone
|
||
Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem... |