194
64
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T62291 | Anti-melanoma agent 1 | ||
Anti-melanoma agent 1 (Compound 5m) 是一种抗黑素瘤剂,能够诱导细胞凋亡(apoptosis)。 | |||
T9521 |
CHR-6494 TFA
|
Others | Others |
CHR 6494 TFA 是一种选择性 haspin 抑制剂,IC50值为 2 nM,可抑制组蛋白 H3T3 的磷酸化。它诱导黑色素瘤、乳腺癌等肿瘤细胞凋亡,可研究癌症。 | |||
T9693 |
TBAP-001
|
Raf | MAPK |
TBAP-001是RAF 激酶的泛抑制剂,IC50为 62 nM。 | |||
T9148 |
KA2507
|
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
KA2507 是一种具有口服活性的选择性HDAC6抑制剂, 其IC50值为 2.5 nM。它有抗肿瘤活性和免疫调节作用。 | |||
T8566 |
AA92593
|
Others | Others |
AA92593 是一种选择性的 OPN4 (melanopsin)竞争性拮抗剂。 | |||
T21679 |
4'-bromo-Resveratrol
|
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
4'-Bromo-resveratrol 是Sirtuin-1和Sirtuin-3的双重抑制剂。它通过线粒体代谢重编程,使黑色素瘤细胞的生长受到抑制。它通过代谢重编程、影响细胞周期以及细胞凋亡的信号传导,使其在黑色素瘤细胞中发挥抗增殖作用。 | |||
T10477 |
BAY-985
|
IκB/IKK | NF-κB |
BAY-985 是高效的、ATP 竞争性的、有口服活性的、选择性的TBK1和IKKε双重抑制剂,对 TBK1 (在低/高 ATP 实验中) 和 IKKε 的IC50分别为 2/30 和 2 nM。它具有抗肿瘤作用。 | |||
T41286 |
N6-Isopentenyladenosine
|
Endogenous Metabolite; Autophagy | Autophagy; Metabolism |
N6-Isopentenyladenosine 是甲羟戊酸途径的终产物,是一种具有抗黑色素瘤活性的自噬抑制剂。 N6-Isopentenyladenosine 是一种在细胞分裂素中发现的 RNA 修饰,可调节植物生长/分化,提高翻译的效率和准确性。 | |||
T24269 |
KPT-251
KPT251 |
Others | Others |
KPT-251 是一种选择性核输出抑制剂。 | |||
T3560 |
Desmethylanethol trithione
ADT-OH |
VEGFR; Akt | Angiogenesis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
Desmethylanethol trithione (ADT-OH) 是合成硫化氢的供体。它利用上调 FADD 诱导细胞凋亡,并对体内黑色素瘤的形成具有一定的抑制作用,可用于研究癌症疾病。 | |||
T35407 |
Ζ-Stat
|
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
ζ-Stat 是非典型的、特异性的PKC-ζ抑制剂,IC50为 5 μM。ζ-Stat 能够减少黑色素瘤细胞系的增殖并诱导细胞凋亡,在体外显示除抗肿瘤活性。 | |||
T1867 |
Otenaproxesul
ATB 346 |
Apoptosis; COX | Apoptosis; Immunology/Inflammation; Neuroscience |
Otenaproxesul (ATB 346) 是一种具有口服活性的非甾体抗炎药,可抑制环氧合酶-1 和 2,具有抗炎生物活性,可用于缓解疼痛的研究。 | |||
T11553 |
Heptamidine dimethanesulfonate
SBi4211 dimethanesulfonate |
Others | Others |
Heptamidine dimethanesulfonate (SBi4211 dimethanesulfonate) 是一种与喷他脒有关的、强效的钙结合蛋白 S100B 的抑制剂 (Kd=6.9 μM),选择性地杀死表达 S100B 的黑素瘤细胞。它是有效的强直性肌营养不良 (DM) 研究工具。 | |||
T1120 |
Dacarbazine
Imidazole Carboxamide,达卡巴嗪,DTIC-Dome |
Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Dacarbazine (DTIC-Dome) 是一种抗肿瘤剂,对黑色素瘤具有显着的活性。 | |||
T8745 |
PROTAC BRAF-V600E degrader-1
Compound 23 |
Raf | MAPK |
PROTAC BRAF-V600E degrader-1 (Compound 23) 选择性地诱导 BRAF-V600E 的降解,而不是野生型 BRAF。 | |||
T6609 |
NMS-E973
|
HSP | Cytoskeletal Signaling; Metabolism |
NMS-E973 是一种有效且选择性的 Hsp90 抑制剂,与 Hsp90 结合的 DC50小于 10 nM。它能够穿越血脑屏障,具有抗肿瘤效果。 | |||
T22136 |
PRL-3 Inhibitor I
PRL-3 Inhibitor,BR-1 |
Phosphatase; Others | Metabolism; Others |
PRL-3 Inhibitor I (BR-1) 是 PRL-3 抑制剂,IC50=0.9 μM。它在细胞检测中显示降低侵袭性。 | |||
T7188 |
Piclidenoson
CF-101,IB-MECA |
Apoptosis; Adenosine Receptor | Apoptosis; GPCR/G Protein; Neuroscience |
Piclidenoson (CF-101) 是一种具有口服活性的,选择性的腺苷 A3 受体激动剂。它在不同类型的癌细胞如黑色素瘤、白血病中表现出抗增殖和诱导凋亡的作用,可研究自身免疫性炎症疾病和 COVID-19。 | |||
T1992 |
Mertansine
DM1,Maytansinoid DM1 |
Microtubule Associated | Cytoskeletal Signaling |
Mertansine (DM1) 是一种微管蛋白抑制剂,也是一种抗体可缀合的美登木素生物碱。它通过连接体连接到单克隆抗体上,形成抗体偶联药物。 | |||
T7764 |
CCG-222740
|
ROCK; Rho; Ras | Cell Cycle/Checkpoint; Cytoskeletal Signaling; GPCR/G Protein; MAPK; Stem Cells |
CCG-222740 是一种口服有效的选择性Rho/MRTF 途径抑制剂。它也是 α-平滑肌的肌动蛋白表达抑制剂,可减少皮肤纤维化并阻止黑色素瘤转移。 | |||
T10104 |
3,4-Dihydroxybenzylamine hydrobromide
NSC 263475 hydrobromide,3,4-二羟基苄胺·氢溴酸 |
Others; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others |
3,4-Dihydroxybenzylamine hydrobromide (NSC-263475 hydrobromide) 抑制黑色素瘤细胞中的 DNA 聚合酶活性,并在具有不同程度酪氨酸酶活性的黑色素瘤细胞系中显示出生长抑制活性。 | |||
T0509 |
Cloxiquine
5-Chloro-8-quinolinol,氯羟喹,Dermofungin,Dermofongin,5-氯-8-羟基喹啉 |
Antibacterial; Antibiotic; PPAR; Parasite; Antifungal | DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Cloxiquine (Dermofongin) 具有抗菌,抗真菌和抗阿米巴虫的作用。它还可通过激活 PPARγ抑制黑素瘤细胞的生长和转移。它可研究结核病和皮肤病。 | |||
T8740 |
COH-SR4
COH-SR4 (Mitochondria uncoupler SR4) |
Others; AMPK | Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling |
COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) 是线粒体氧化磷酸化的解偶联剂,可调节 amp 依赖性激酶 (ampk)-雷帕霉素 (mtor) 信号的哺乳动物靶点,并抑制 hepg2 肝癌细胞的增殖。它对白血病、黑色素瘤、乳腺癌和肺癌显示出强大的抗增殖活性。它是一种AMPK 活化剂,通过激活 AMPK 来抑制脂肪细胞分化,可用于肥胖及代谢紊乱相关的研究。 | |||
T23861 |
CAY10526
CAY-10526,BTH,CAY 10526 |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
CAY10526 (BTH) 是 mPGES-1 的选择性抑制剂,可抑制 NF-κB 信号通路。 | |||
T36573 |
NHWD-870
|
Apoptosis; Epigenetic Reader Domain | Apoptosis; Chromatin/Epigenetic |
NHWD-870 是一种有效且特异性的 BET 家族溴结构域抑制剂,仅与 BRD2、BRD3、BRD4 (IC50 = 2.7 nM) 和 BRDT 结合。 NHWD-870 具有强大的抗肿瘤功效,并通过增加肿瘤细胞凋亡和抑制肿瘤增殖来抑制癌细胞-巨噬细胞相互作用。 | |||
T10395L |
ATM-3507
|
Others | Others |
ATM-3507 is an inhibitor of tropomyosin. In human melanoma cell lines, the IC50s are from 3.83-6.84 μM. | |||
T28206 |
NSC49652
NSC 49652,NSC-49652 |
Apoptosis | Apoptosis |
NSC49652 在神经元和黑色素瘤细胞中触发依赖于 p75NTR 和 JNK 活性的凋亡细胞死亡,并抑制黑色素瘤小鼠模型中的肿瘤生长。 | |||
T27792 |
L-Alaninol
2-Aminopropanol |
||
L-Alaninol, an amino acid derivative, inhibits melanoma proliferation and increases cytrochrome C reductase and tau-glutamyl transpeptidase. | |||
T11854 |
Lipofermata
|
Others; Antibacterial | Microbiology/Virology; Others |
Lipofermata 是一种脂肪酸转运蛋白 2抑制剂,可阻止脂质转运至黑色素瘤细胞并减少黑色素瘤的生长和侵袭。 | |||
T7712L |
Disomotide TFA 181477-43-0(free base)
|
Others | Others |
Disomotide TFA 181477-43-0(free base) 是一种用于治疗黑色素瘤的寡肽。 | |||
T28001 |
MDK-6983
MDK-6983,Compound 6k,Autophagy inhibitor 6k,MDK6983 |
Autophagy | Autophagy |
MDK-6983 (MDK-6983) 是一种自噬抑制剂,可破坏人黑色素瘤细胞中肌动蛋白细胞骨架的动力学。 | |||
T27454 |
GSK2008607
|
Raf | MAPK |
GSK2008607是 一种有效的 B-RafV600E 抑制剂,具有抗癌活性,可用来研究乳腺癌、结直肠癌、黑色素瘤、甲状腺癌、卵巢癌。 | |||
T35300 |
Zeniplatin
Zeniplatinum |
Others | Others |
Zeniplatin (Zeniplatinum) 是一种新顺铂复合物,具有抗癌活性,可用于治疗转移性黑色素瘤和肾癌。 | |||
T9869 |
N-[2-(diethylamino)ethyl]-2-iodobenzamide
|
Others | Others |
N-[2-(diethylamino)ethyl]-2-iodobenzamide 是一种放射性药物。用于黑色素瘤和转移的闪烁扫描检测。 | |||
T17195 |
UC-112
|
Others | Others |
UC-112是凋亡抑制蛋白IAP 新型高效抑制剂,癌细胞IC50值0.7-3.4uM。 | |||
T8654 |
Plx-4032
维罗非尼,Vemurafenib |
Raf | MAPK |
Plx-4032 (Vemurafenib) 是一种小分子 B-Raf 抑制剂,可用于治疗恶性黑色素瘤。 | |||
T16871 |
Semustine
|
DNA Alkylator/Crosslinker | DNA Damage/DNA Repair |
Semustine 是一种 DNA 烷化剂,是一种癌症化疗化合物,在接受辅助化疗的恶性黑色素瘤患者中具有肾毒性,可用于辅助治疗白血病。 | |||
T77743 |
TT-012
|
Others | Others |
TT-012 具有抗肿瘤活性,选择性结合动态 MITF,并破坏后者的二聚体形成和 DNA 结合。TT-012 对 B16F10 黑色素瘤细胞中 MITF 的转录有抑制作用。TT-012 在动物模型中对 MITF黑色素瘤细胞的生长和肿瘤生长转移有抑制作用。TT-012 对肝脏和免疫细胞具有较少的细胞毒性。 | |||
T77118 |
Plozalizumab
MLN-1202 |
CCR | Immunology/Inflammation; Microbiology/Virology |
Plozalizumab (MLN-1202) 是一种人源化具有选择性和有效性的抗 CCR2 抗体。Plozalizumab 具有抗肿瘤活性。Plozalizumab 可用于研究恶性黑色素瘤。 | |||
T11209 |
EOAI3402143
|
DUB | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination |
EOAI3402143 是一种去泛素化酶抑制剂,以剂量依赖性抑制 Usp9x/Usp24和 Usp5,增加肿瘤细胞凋亡。 | |||
T77751 |
Imaprelimab
PRX-003 |
Others | Others |
Imaprelimab (PRX-003) 是一种人源化抗黑素瘤细胞粘附分子 (MCAM) 的 IgG1κ 单克隆抗体。Imaprelimab 具有抗肿瘤活性,可用于研究炎症、肿瘤、银屑病。 | |||
T7088 |
Diflubenzuron
Dimilin,氟脲杀,Difubenzuron,Larvakil,Difluron |
P450 | Metabolism |
Diflubenzuron (Larvakil) 是杀虫剂 Dimilin 的有效成分,具有杀幼虫和杀卵作用。 | |||
T6855 |
HA15
|
Apoptosis; GPR; Others; HSP; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; Endocrinology/Hormones; GPCR/G Protein; Metabolism; Others |
HA15 是一种高效特异性内质网伴侣蛋白BiP/GRP78/HSPA5抑制剂,抑制 BiP 的 ATP 酶活性,具有抗肿瘤活性。 | |||
T5341 |
WYC-209
WYC209 |
Apoptosis; Retinoid Receptor; Autophagy | Apoptosis; Autophagy; Metabolism |
WYC-209 是一种合成类视黄醇,是维甲酸受体激动剂。它主要通过 caspase 3途径抑制恶性鼠黑色素瘤肿瘤再生细胞的增殖,IC50值为 0.19 μM。 | |||
T28145 |
ND-322 HCl
ND 322 Hydrochloride,ND322 Hydrochloride,ND-322 Hydrochloride,ND322 HCl |
MMP | Proteases/Proteasome |
ND-322 HCl (ND 322 Hydrochloride) 是 MT1-MMP 和 MMP2 的选择性抑制剂,可减少体外黑色素瘤细胞的生长、迁移和侵袭。 | |||
T2503 |
PAC-1
Procaspase activating compound 1 |
Apoptosis; Caspase; Autophagy | Apoptosis; Autophagy; Proteases/Proteasome |
PAC-1 (Procaspase activating compound 1) 是一种 procaspase-3激活剂,诱导癌细胞凋亡,EC50为 2.08 μM,可用于研究淋巴瘤、黑色素瘤、实体瘤、乳腺癌和胸癌等治疗的试验。 | |||
T12731 |
RIPK1-IN-7
|
RIP kinase | Apoptosis; NF-κB |
RIPK1-IN-7 是一种选择性有效的 RIPK1 抑制剂,Kd 值为 4 nM,IC50值为 11 nM。在实验性 B16 黑色素瘤肺转移模型中表现出优异的抗转移活性。 | |||
TP1097 |
Melanotan I
美拉诺坦,美拉诺坦 I,[Nle4,D-Phe7]-α-MSH,Afamelanotide,MT-I |
Others | Others |
Melanotan I 是一种非特异性黑素皮质激素受体 (MCR) 激动剂, 是一种 α- 黑素细胞刺激激素 (α-MSH) 类似物,皮下注射可增加黑色素在皮肤中的含量。Melanotan I 可用于辅助美黑。Melanotan I 可用于预防阳光诱发皮肤癌,可用于研究黑色素瘤和男性勃起功能障碍。 | |||
T35688 |
MTIC
NSC 407347 |
Drug Metabolite | Metabolism |
MTIC 是 Temozolomide (TMZ) 的活性代谢物,具有抗癌抗肿瘤活性,可用于研究黑色素瘤。 | |||
T6949 |
PLX7904
PB04 |
Raf | MAPK |
PLX7904 (PB04) 是一种有效且选择性的悖论破坏剂 RAF 抑制剂,可抑制突变 BRAF 黑色素瘤细胞中 ERK1/2 的激活。在表达突变体 RAS 的细胞中,对 BRAFV600E 的IC50值约为 5 nM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9135 |
Epirosmanol
|
Others | Others |
Epirosmanol 是含有内酯部分的二萜类化合物。 Epirosmanol 是一种极弱碱性(基本中性)的化合物(基于其 pKa)。 | |||
TN2069 |
Picrocrocin
藏红花,苦番紅花素 |
Apoptosis | Apoptosis |
Picrocrocin 是一种从椰菜花中发现的类胡萝卜素,对 SKMEL-2 人恶性黑色素瘤细胞具有生长抑制作用,具有抗癌作用。 | |||
T5S0055 |
Chelidonine
Helidonine,Khelidonin,白屈菜碱,Stylophorin |
Apoptosis; Others; Influenza Virus | Apoptosis; Microbiology/Virology; Others |
Chelidonine (Stylophorin) 是白屈菜中的一种异喹啉生物碱,有抗肿瘤和抗病毒作用。它可导致细胞周期 G2/M 停滞,诱导 caspase 依赖和非依赖性的细胞凋亡。 | |||
T1310 |
2-Thiouracil
Thiouracil,硫代由雪,Deracil,2-硫脲嘧啶 |
Thyroid hormone receptor(THR); NO Synthase | Endocrinology/Hormones; Immunology/Inflammation |
2-Thiouracil (Deracil) 是神经型一氧化氮合酶 (nNOS) 的选择性抑制剂(Ki:20 μM),是一种抗甲状腺化合物,可用作高度特异性的黑色素瘤探测物。 | |||
T2819 |
Methyl p-coumarate
对羟基肉桂酸乙酯,4-羟基肉桂酸甲酯,Methyl 4-hydroxycinnamate |
Others; Antifungal | Microbiology/Virology; Others |
Methyl 4-hydroxycinnamate 是一种从 Trixis michuacanavarlongifolia 的花中分离出来的对香豆酸的酯化衍生物,有抗菌和抗黑色素形成的作用。 | |||
T7203 |
Oglufanide
奥谷法奈,L-Glutamyl-L-tryptophan,H-Glu-Trp-OH |
VEGFR; HCV Protease; Endogenous Metabolite | Angiogenesis; Metabolism; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Oglufanide (H-Glu-Trp-OH) 是一种从小牛胸腺中分离出来的二肽免疫调节剂,可抑制血管内皮生长因子,可刺激细胞内细菌感染和对丙型肝炎病毒的免疫反应。 | |||
T4745 |
4-Carboxyquinoline
QUINOLINE-4-CARBOXYLIC ACID,喹啉-4-羧酸,4-Quinolinecarboxylic acid |
Others; Endogenous Metabolite | Metabolism; Others |
4-Carboxyquinoline (4-Quinolinecarboxylic acid) 是内源性代谢产物的一种。 | |||
TN3605 |
Casegravol
|
Others | Others |
Casegravol shows antiproliferative activity against human gastric adenocarcinoma (MK-1), human uterus carcinoma (HeLa), and murine melanoma (B16F10) cells. | |||
TN3594 |
Cardanol (C15:1)
|
Apoptosis; Others | Apoptosis; Others |
Cardanol (C15:1) 存在于腰果壳液中,可诱导人黑色素瘤细胞线粒体相关的细胞凋亡。 | |||
TN6705 |
Graveoline
1-甲基-2- [3' ,4' - (亚甲二氧基)苯基] -4-喹诺酮,2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one,Foliosine |
Autophagy | Autophagy |
Graveoline (2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one) 是皮肤黑色素瘤癌细胞的凋亡和自噬诱导剂。 | |||
TQ0213 |
Bruceantin
鸦胆亭,(-)-Bruceantin,NCI165563,鸦胆停,NSC165563 |
Others | Others |
Bruceantin (NSC-165563) 提取自痢鸦胆子中,显示出对 B16黑色素瘤,结肠癌38,L1210和白血病 P388的抑制活性。 | |||
T3S0153 |
Xanthatin
苍耳亭,叶黄制菌素 |
Apoptosis; VEGFR; Lipoxygenase; Wnt/beta-catenin; Antibacterial | Angiogenesis; Apoptosis; Cytoskeletal Signaling; Metabolism; Microbiology/Virology; Stem Cells; Tyrosine Kinase/Adaptors |
Xanthatin 是一种从Xanthium strumarium 叶子中提取的天然产物,可诱导细胞凋亡。它抑制布鲁氏菌的IC50值为 2.63 μg/ mL,对寄生虫特异性锥虫硫磷还原酶具有不可逆的弱抑制作用。它通过抑制PGE2的合成和 5-脂氧合酶的活性而显示出抗炎活性。 | |||
T5646 |
Cinnamic acid
3-Phenylacrylic acid,β-Phenylacrylic acid,肉桂酸 |
Endogenous Metabolite | Metabolism |
Cinnamic acid (β-Phenylacrylic acid) 在癌症干预中具有潜在的应用价值,对胶质母细胞瘤,黑色素瘤,前列腺癌,肺癌细胞的IC50=1-4.5 mM。 | |||
T3810 |
Saikosaponin B2
柴胡皂苷 B2,柴胡皂甙 B2 |
Others; HCV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Saikosaponin B2 是从柴胡根中分离得到的一种活性成分,可抑制 HCV 病毒感染的侵入,有抗癌作用。 | |||
T5S0506 |
Rotundic acid
Rutundic acid,铁冬青酸 |
Apoptosis; Others; p38 MAPK; Akt; mTOR | Apoptosis; Cytoskeletal Signaling; MAPK; Others; PI3K/Akt/mTOR signaling |
Rotundic acid (Rutundic acid) 是一种从圆形肠球菌中获得的三萜类天然产物,具有抗炎和保护心脏的能力。它可通过 AKT/mTOR 和 MAPK 途径在肝细胞癌中诱导 DNA 损伤和细胞凋亡。 | |||
TN6339 |
(R)-5-Hydroxy-1,7-diphenylheptan-3-one
(5R)-Dihydroyashabushiketol,(R)-5-羟基-1,7-二苯基-3-庚酮 |
Others | Others |
(R)-5-Hydroxy-1,7-diphenylheptan-3-one ((5R)-Dihydroyashabushiketol) 是从中药材高良姜的根茎中提取的。它抑制茶碱刺激的鼠 B16 黑色素瘤 4A5 细胞中的黑色素生成。 | |||
TN1873 |
Lirinidine
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Others | Others |
Lirinidine 是一种分离自L. tulipifera 叶片生物碱,具有抗氧化 (antioxidant) 和抗癌作用。它在体外表现出中等的铁还原能力和较小的自由基清除能力,可用于研究化妆品。 | |||
TN6972 |
Methyl pentadecanoate
|
Others | Others |
Methyl pentadecanoate 是一种天然产物。它是由肉豆蔻酸酯化得到的饱和脂肪酸甲酯。肉豆蔻酸甲酯(Methyl myristate) 在 B16F10 黑色素瘤中显示出高黑色素诱导。 | |||
T4518 |
Licochalcone D
|
ERK; NF-κB | MAPK; NF-κB |
Licochalcone D 是一种 NF-κB p65的有效抑制剂,是一种存在于 Glycyrrhiza inflate 中的黄酮类化合物,具有抗氧化、抗炎、抗癌等作用。 | |||
T2P2806 |
Hederacolchiside A1
黑海常春藤苷A1,革叶常春藤皂苷 A1,Raddeanoside R13 |
Apoptosis; ERK; MEK; Akt; PI3K; Parasite; mTOR | Apoptosis; Cytoskeletal Signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling |
Hederacolchiside A1 (Raddeanoside R13) 是从白头翁中分离的一种有抗利什曼原虫和抗肿瘤增殖活性的天然产物。 | |||
T3S0645 |
N-trans-Feruloyltyramine
Feruloyltyramine,N-Feruloyltyramine,Moupinamide,N-反式阿魏酰酪胺 |
Others; COX | Immunology/Inflammation; Neuroscience; Others |
N-trans-Feruloyltyramine (Feruloyltyramine) 是从大麻中分离得到的一种生物碱,是COX1和COX2的抑制剂,具有抗氧化和抗炎活性。 | |||
T7052 |
Gnetol
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Tyrosinase; COX; HDAC; AChR | Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Neuroscience; Proteases/Proteasome |
Gnetol 是从买麻藤的根中分离出来的一种酚类。它是酪氨酸酶抑制剂,对鼠酪氨酸酶的 IC50为 4.5 μM,可抑制黑色素的生物合成。它有效抑制 COX-1和 HDAC,具有抗氧化、抗增殖、抗癌和保肝活性,还具有浓度依赖性的 α-淀粉酶、α-葡萄糖苷酶和脂肪形成活性。 | |||
TN1516 |
Cnidicin
蛇床素,4,9-双[(3-甲基-2-丁烯-1-基)氧基]-7H-呋喃并[3,2-G][1]苯并吡喃-7-酮 |
NOS; NO Synthase | Immunology/Inflammation |
Cnidicin 是一种香豆素,对肥大细胞脱颗粒及 RAW 264.7 细胞产生一氧化氮具有抑制作用。 | |||
T4S1551 |
Cinnamaldehyde
Cinnamic Aldehyde,肉桂醛 |
HIF | Angiogenesis; Chromatin/Epigenetic |
Cinnamaldehyde (Cinnamic Aldehyde) 具有解热作用。 它是镇静剂。它抑制MDA-MB-435S 细胞的侵袭能力与下调miR-27a 的表达有关。它诱导活性氧的产生,发挥血管扩张和抗癌作用。 它似乎是一种有希望的候选药物,可作为与 5-氟尿嘧啶 (5-FU) 和奥沙利铂 (OXA) 这两种用于 CRC 治疗的化疗药物联合治疗的辅助剂。其作用的可能机制可能涉及药物代谢基因的调节。 它在抑制黑色素瘤的发生和发展方面具有一定的作用,其作用机制可能表现为抑制VEGF 和HIF-α的表达,从而使血管模拟和黑色素瘤细胞新生血管的形成,促进肿瘤的生长。 | |||
TN2601 |
12-O-Methylcarnosic acid
|
Reductase | Endocrinology/Hormones; Metabolism |
12-O-Methylcarnosic acid 是分离自小叶丹参的丙酮提取物的一种二萜肉桂酸,可抑制 5α-还原酶 (5α-reductase) 活性,IC50为 61.7 μM。它抑制 LNCaP 细胞的增殖。它具有抗微生物活性、抗氧化和抗癌活性。 | |||
T2924 |
Phloretin
根皮素,Dihydronaringenin,NSC 407292,RJC 02792 |
SGLT; transporter; Endogenous Metabolite | GPCR/G Protein; Metabolism |
Phloretin (NSC-407292) 是从苹果树叶中提取的一种查耳酮,具有抗炎、抗氧化和抗癌活性。它是真核尿素转运蛋白抑制剂,可阻断 VacA 介导的尿素和离子转运,有潜力用于类风湿性关节炎和过敏性气道炎症的相关研究。 | |||
T3229 |
Cytochalasin D
|
ATPase; p38 MAPK; Calcium Channel; Akt; PI3K | Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling |
Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibit | |||
TCS2170 |
2,5-Dihydroxyacetophenone
Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,2 ',5'-二羟基苯乙酮,Acetylhydroquinone,2,5-二羟基苯乙酮,DHAP |
ERK; NF-κB; Tyrosinase | MAPK; NF-κB; Proteases/Proteasome |
2,5-Dihydroxyacetophenone (Quinacetophenone) 是从熟地黄中分离出的一种天然产物,通过阻断 ERK1/2和 NF-κB 信号通路,抑制活化巨噬细胞中炎症介质的产生。 | |||
T4S0797 |
Berberine
小檗碱,Berberin,Umbellatine,黄连素 |
Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy | Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Berberine (Umbellatine) 是从中草药黄连中分离出来的一种生物碱抗生素。它诱导活性氧生成并抑制 DNA 拓扑异构酶,具有抗肿瘤特性。 | |||
T24075 |
Fusarochromanone
NSC-627608,FC101,NSC 627608,FC-101,FC 101 |
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Fusarochromanone is a melanoma growth inhibitor. | |||
TN5329 | Epitulipinolide diepoxide | ||
Epitulipinolide diepoxide has antioxidative and chemopreventive activities in skin melanoma cells, can significantly inhibit the proliferation of melanoma cells, it possesses cytotoxic activity against KB cells. | |||
TN5300 |
Citrostadienol
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Citrostadienol shows cytotoxic activity against B16F10 melanoma cells. | |||
T23773 |
Barbigerone
Barubigeron |
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Barbigerone is a tumor angiogenesis, growth, and metastasis inhibitor in melanoma. | |||
TN3682 |
Clerosterol glucoside
|
Others | Others |
Clerosterol exerts its cytotoxic effect in A2058 human melanoma cells by caspases-dependent apoptosis. | |||
T2S0799 | Noroxyhydrastinine | Tyrosinase | Proteases/Proteasome |
Noroxyhydrastinine exhibits potent melanogenesis-inhibitory activities, it inhibits melanogenesis, at least in part, by inhibiting the expression of protein levels of tyrosinase, TRP-1, and TRP-2 in α-MSH-stimulated B16 melanoma cells. | |||
TN2923 | 3'-Deoxy-4-O-methylsappanol | Tyrosinase | Proteases/Proteasome |
3'-Deoxy-4-O-methylsappanol shows moderate cytotoxicities against cultured human melanoma HMV-II cells with the IC50 value of 872.0 uM ± 2.4. | |||
TN6054 | Norglaucine hydrochloride | ||
(+)-Norglaucine shows cytotoxic activity toward the tumor cell lines B16-F10 (mouse melanoma), HepG2 (human hepatocellular carcinoma), K562 (human chronic myelocytic leukemia) and HL-60 (human promyelocytic leukemia) and non-tumor peripheral blood mononuc | |||
TN5212 |
Uvedalin
|
Others | Others |
Uvedalin shows cytotoxicity against HeLa, HL-60, and Murine B16-F10 melanoma cell lines. | |||
TN1486 |
Chimonanthine
|
Others | Others |
(-)-Chimonanthine (IC50 = 0.93 μM) shows potent inhibitory effects on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. | |||
TN4642 |
Neorauflavane
|
Tyrosinase | Proteases/Proteasome |
Neorauflavane shows tyrosinase inhibition, it can inhibit tyrosinase monophenolase activity with an IC50 of 30 nM, it also can efficiently reduce melanin content in B16 melanoma cells with 12.95 uM of IC50. | |||
TN3842 | Diarylcomosol III | Others | Others |
Diarylcomosol III shows inhibitory effects on melanogenesis in B16 melanoma cells, it is a promising therapeutic agent for the treatment of skin disorders. | |||
TN3681 |
Clerosterol
|
BCL; Caspase | Apoptosis; Proteases/Proteasome |
Clerosterol as a precursor of cyasterone, isocyasterone and 29-norcyasterone in biosynthesis of phytoecdysteroids of Ajuga hairy roots. Clerosterol exerts its cytotoxic effect in A2058 human melanoma cells by caspases-dependent apoptosis. | |||
TN3726 | Cudraflavone B | IκB/IKK; MAO; ROS; Akt; COX; PI3K; Nrf2; Autophagy | Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling |
Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mouse melanoma cells, and hepatoprotective activity. It may be a lead for the development of a potential candidate for human oral squamous cell carcinoma cells. | |||
T28522 |
Reticulol
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Reticulol is an isocoumarin derivative produced by certain species of Streptomyces. Reticulol inhibits cAMP phosphodiesterase (IC50 = 41 µM). Recticulol (M.W. 222.2) exhibits a potent in vitro cytotoxicity against the human lung tumor cell line A427 and the mouse melanoma cell line B16F10. | |||
TN3644 | Chlorophorin | Tyrosinase; Antifection | Microbiology/Virology; Proteases/Proteasome |
Chlorophorin shows high anti-protozoal activity with an MIC of 0.25 microg/ml. Chlorophorin can strongly inhibit mushroom tyrosinase activity with IC50 values of 2.5 ± 0.408 uM; it inhibits α-melanocyte-stimulating hormone-induced melanin production in B16F10 melanoma cells. | |||
TN3723 | Cryptomeridiol | PAFR; Antifection | GPCR/G Protein; Microbiology/Virology |
Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low activity against A. niger, T. mentagrophytes, and C. albicans. (-)-Cryptomeridiol also exhibits a significant and concentration-dependent inhibitory effect on PAF receptor binding, with inhibitory concentration (IC)(50) values of 17.5 uM. | |||
TN6010 |
Picrasidine S
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Picrasidine S shows the potent cytotoxicity against human HeLa cervical, gastric MKN-28, and mouse melanoma B-16 cancer cells, it also shows the potent antibacterial activity against two strains of pathogenic bacteria methicillin-resistant Staphylococcus | |||
T83762 |
Lentztrehalose C
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Lentztrehalose C,一种在Lentzea中发现的二糖,具有诱导自噬活性。在100 mM浓度下,它能诱导MeWo黑色素瘤细胞和OVK18卵巢癌细胞进行自噬。 | |||
TN4699 | Ohchinin | Others | Others |
Ohchinin exhibits potent inhibitory activities with 26 - 66% reduction of melanin content at 100 μm concentration with almost no or low toxicity to the B16 melanoma cells (70 - 99% cell viability at 100 μm). | |||
TN1583 |
Dihydromorin
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TRP/TRPV Channel | Membrane transporter/Ion channel |
trans-Dihydromorin is an effective hypopigmenting agent in normal skin cells, hypopigmenting agents effective in melanoma system may not be effective on normal melanocytes, indicating that a non-tumor melanocyte system is more suitable for the screening o | |||
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