48
38
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6835 |
Fenoldopam mesylate
Fenoldopam methanesulfonate,SKF-82526 mesylate,Corlopam mesylate,mesylate,SKF 82526,非诺多泮甲磺酸盐 |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Fenoldopam mesylate (Corlopam mesylate) 是一种多巴胺受体D1选择性激动剂。 | |||
T23480 |
U-83836E
|
Others | Others |
U-83836E (lazaroid ) 具有神经保护活性和抗肿瘤活活性,抑制神经胶质瘤细胞增殖,抑制肿瘤坏死因子并逆转内毒素诱导的休克。 | |||
T25214 |
CCR-11
CCR11,CCR 11 |
Antibiotic | Microbiology/Virology |
CCR-11 是一种具有抗菌活性的绕丹宁衍生物。 CCR-11 可以抑制 B. subtilis细胞和 HeLa 细胞增殖。 CCR-11 通过抑制 FtsZ 的组装和 GTPase 活性来抑制细菌增殖和细菌胞质分裂。 CCR-11 具有潜在的抗肿瘤活性,可用于研究乳腺癌和小儿骨髓增生异常。 | |||
T60102L |
Dimethylaminomicheliolide HCl
|
PKM | Metabolism |
Dimethylaminomicheliolide HCl 具有潜在的抗炎和抗肿瘤活性,通过靶向丙酮酸激酶 2 (PKM2) 和重新连接有氧细胞群来抑制胶质母细胞瘤细胞的增殖。 | |||
T5351L |
PU-WS13 hydrobromide
PU-WS13 hydrobromide (1454619-14-7 Free base) |
GPR | Endocrinology/Hormones; GPCR/G Protein |
PU-WS13 hydrobromide 是一种 GRP94 抑制剂,具有抗炎活性,对小鼠 TNBC 肿瘤中的 M2 样巨噬细胞的增殖具有抑制作用。 | |||
T60269 |
ZINC194100678
|
PAK | Cytoskeletal Signaling |
ZINC194100678是一种有效的PAK1抑制剂,IC50值为8.37μM 。ZINC194100678 具有较强的抗增殖活性,对MDA-MB-231的IC50值为40.16μM。ZINC194100678可用于癌症的研究。 | |||
T78212 |
KRAS G12D inhibitor 18
KRAS G12D IN 18 |
Others | Others |
KRAS G12D inhibitor 18 为一种有效的 KRAS G12D 抑制剂,具有潜在的抗肿瘤和抑制肿瘤细胞增殖的活性,可用于研究胰腺癌。 | |||
T67899 |
Topoisomerase II inhibitor 13
|
Topoisomerase | DNA Damage/DNA Repair |
Topoisomerase II inhibitor 13抑制拓扑异构酶II (Topo II),对HL-60衍生的HL-60/MX2癌细胞具有较强的抗Topo II 毒性的抗增殖活性。 | |||
T67746 |
IMS2186
|
Others | Others |
IMS2186 是一种抗脉络膜新生血管 (CNV) 试剂, 可以使癌细胞周期阻滞在 G2/M 期,由此产生抗增殖和抗血管生成作用。IMS2186 能够减少眼睛渗漏和病变细胞的数量,并且无眼内毒性。 | |||
T76796 |
Patritumab
U3-1287,AMG-888 |
ERK; EGFR; Akt; HER | Angiogenesis; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
Patritumab(U3-1287)是抗 HER3 单克隆抗体,具有潜在的抗肿瘤活性,对 EGFR,HER2,HER3,ERK 和 AKT 的磷酸化有抑制作用和。Patritumab 促使细胞凋亡 (apoptosis),抑制非小细胞肺癌的增殖。 | |||
T6891 |
MK-4101
|
Apoptosis; Hedgehog/Smoothened; Smo | Apoptosis; GPCR/G Protein; Stem Cells |
MK-4101 是一种 SMO 拮抗剂 ,对 293 细胞的 IC50为 1.1 µM。它也是一种 hedgehog 信号通路的有效抑制剂 ,对小鼠细胞和KYSE180 食管癌细胞的IC50分别为 1.5 µM 和 1 µM。它能抗肿瘤,抑制肿瘤细胞增殖并诱导细胞凋亡。 | |||
T35885 |
KRM-III
|
Others | Others |
KRM-III 是一种具有口服活性的 T 细胞抗原受体 (TCR) 抑制剂,具有抗炎活性,可有效抑制 TCR 和肉豆蔻酸乙酸酯/佛波霉素/离子霉素诱导的 NFAT 核因子活化和 T 细胞增殖,IC50 约为 5 μM。 | |||
T24167 |
Inflachromene
ICM |
Others | Others |
Inflachromene(ICM) 是一种 HMGB1 和 HMGB 表达抑制剂,具有抗炎活性。Inflachromene 通过抑制 HMGB1 易位来减轻小鼠癫痫模型的癫痫发作严重程度,通过 HMGB1/2 调节的 TLR4-NF-κB 通路抑制内膜增生,通过调节 Beclin 1 活性来抑制自噬。Inflachromene 可用于研究癫痫。 | |||
T68170 |
xl-281
|
||
XL-281是一种有效的,选择性的,口服活性的野生型和突变型 RAF 激酶抑制剂,在多种异种移植模型中具有抗肿瘤活性;通过调节肿瘤和替代组织中的 RAF 途径证明生物活性,细胞增殖减少,细胞凋亡增加。 | |||
T17208 |
USL311
|
CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
USL311 是选择性 CXCR4拮抗剂,可防止基质细胞衍生因子 1(SDF-1 或 CXCL12)与 CXCR4 结合。它抑制 CXCR4 活化并减少表达 CXCR4 的肿瘤细胞的增殖和迁移,具有抗肿瘤活性。 | |||
T83658 |
SQLE-IN-1
|
Antifungal | Microbiology/Virology |
SQLE-IN-1 是一种角鲨烯环氧化酶 (SQLE) 抑制剂,具有抗肿瘤活性,可抑制肝癌细胞系 Huh7 的增殖和迁移能力,抑制细胞胆固醇的生成,增加抑癌基因PTEN的表达,抑制PI3K和AKT的蛋白表达。 | |||
T11449L |
Golotimod
Gamma-D-glutamyl-L-tryptophan,SCV 07 |
Antibiotic | Microbiology/Virology |
Golotimod (SCV 07) 是一种具有抗菌活性的二肽,具有免疫调节活性,能显著提高抗结核治疗的疗效,诱导胸腺和脾脏细胞增殖,调节巨噬细胞功能,抑制 STAT3 信号传导。Golotimod 可用于研究复发性生殖器单纯疱疹病毒 2 (HSV-2)感染和口腔黏膜炎。 | |||
T12009 |
Telomerase-IN-1
|
Telomerase | DNA Damage/DNA Repair |
Telomease-IN-1是一种端粒酶抑制剂(IC50:0.19μM)。Telomease-IN-1通过ER 过度反应(EOR)的内质网应激(ERS)激活hTERT 的表达,然后诱导ERS,导致细胞凋亡。Telomease-IN-1通过表达下游信号分子包括CHOP(CAAT /增强子结合蛋白同源蛋白))和线粒体凋亡途径,导致细胞增殖受到抑制。Telomease-IN-1对端粒酶具有较高的抑制活性,对SMMC-7721细胞具有较高的抗增殖能力,对人正常肝细胞无明显毒性作用。Telomease-IN-1 在异种移植肿瘤模型表现出抗肿瘤活性。 | |||
T27129 |
DCE_254
DCE 254,DCE-254,DCE254 |
||
DCE_254 is a novel EZH2 inhibitor, it also displays significant anti-proliferation activity against lymphoma cell lines. | |||
T27130 |
DCE_42
DCE 42,DCE42,DCE-42 |
||
DCE_42 is a novel EZH2 inhibitor, it also displays significant anti-proliferation activity against lymphoma cell lines. | |||
T24858 |
TBZ-07
|
||
TBZ-07 is an anti-angiogenesis and vascular disrupting agent that acts by exhibiting moderate inhibitory cell proliferation activity. | |||
T38720 |
SR-31747 free base
|
||
SR-31747 free base is an immunosuppressive and anti-inflammatory sigma ligand that efficiently inhibits cell proliferation through the inhibition of sterol isomerase activity. | |||
T30511 | BMS-279700 | ||
BMS-279700 is a potent oral activity inhibitor that is part of a new family of aniline 5-azimidazolaquoxaline analogs and has excellent anti-inflammatory activity in vivo, as well as in vitro activity against p56LCK and T cell proliferation, blocking the | |||
T61773 | Keap1-Nrf2-IN-4 | ||
Keap1-Nrf2-IN-4, a powerful neddylation inhibitor, demonstrates significant anti-proliferation activity against MGC-803 cells (IC50 = 2.55 μM), effectively impeding their migration and inducing apoptosis. Additionally, it effectively inhibits tumor growth while exhibiting minimal toxicity [1]. | |||
T74857 | ER degrader 5 | ||
ER degrader 5 是一种有效的 estrogen receptor(ER)降解剂。ER degrader 5 具有抗增殖活性。ER degrader 5 可以用于乳腺癌研究。 | |||
T36674 |
DMU-212
|
Apoptosis; ERK | Apoptosis; MAPK |
DMU-212 是具有口服活性的白藜芦醇的甲基化衍生物,表现出抗分裂、抗增殖、抗氧化和促进细胞凋亡的活性。它通过诱导凋亡和激活ERK1/2蛋白阻止有丝分裂。 | |||
T72708 |
GLS1 Inhibitor-6
|
||
GLS1 Inhibitor-6 是一种具有口服活性的、强效和选择性的谷氨酰胺酶 1 (GLS1) 抑制剂 (IC50=68 nM),对 GLS2 显示出 220 倍的选择性。GLS1 Inhibitor-6 可诱导凋亡,并表现出良好的抗肿瘤活性和抗癌细胞增殖活性。 | |||
T70994 | TAK-659 HCl | ||
TAK-659 is an inhibitor of spleen tyrosine kinase (syk), with potential anti-inflammatory, immunomodulating, and antineoplastic activities. Spleen tyrosine kinase inhibitor TAK-659 may inhibit the activity of syk, which abrogates downstream B-cell receptor (BCR) signaling and leads to an inhibition of B-cell activation, chemotaxis, adhesion and proliferation. Note: TAK-659 free base is less stable. This product is supplied as dihydrochloride form. | |||
T81745 |
MSN8C
|
||
MSN8C为曼索酮E的类似物,作为一种新型人类DNA拓扑异构酶II催化抑制剂,能够诱导癌细胞凋亡,并在体外显著抑制肿瘤细胞增殖。 | |||
T79822 |
DGKα-IN-3
|
||
DGKα-IN-3 作为DGKα抑制剂,具有283 nM的IC50。该化合物能够通过提升T细胞的增殖及功能,显著增强抗PD-1治疗的抗肿瘤效果。因此,DGKα-IN-2在肿瘤和免疫学领域研究中显示出了潜在的应用价值。 | |||
T37644 |
Bengamide B
|
||
Potent inhibitor of NF-κB activation (IC50 = 85 nM); decreases IκBα phosphorylation. Attenuates LPS-induced nitric oxide production and expression of TNF-α, IL-6 and MCP. Suppresses proliferation of HeLa and HCT116 cells. Anti-inflammatory and antitumor. Hu et al (2007) Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases. Chem.Biol. 14 764 PMID:17656313 |Johnson et al (2012) Myxobacteria versus sponge-derived alkaloids: the be... | |||
T79668 |
PIK5-12d
|
Autophagy | Autophagy |
PIK5-12d为一种高效的PROTAC PIKfyve降解剂,具有显著的DC50值为1.48 nM。该化合物在多种前列腺癌细胞系中有效诱导细胞质空泡化,同时阻碍自噬流的进行,有效抑制前列腺癌细胞的增殖,并展现出抗肿瘤活性。 | |||
T74060 |
AZ'6421
|
||
AZ'6421 作为一种靶向蛋白水解嵌合体 (PROTAC),专门用于选择性降解雌激素受体α,展现了显著的抗肿瘤效果,能有效遏制因癌症导致的细胞无控制增殖,尤其适用于乳腺癌等癌症研究。 | |||
T61098 |
RUNX1/ETO tetramerization-IN-1
|
||
RUNX1/ETO tetramerization-IN-1 is a small-molecule inhibitor that specifically targets NHR2 of RUNX1/ETO, effectively inhibiting the tetramerization process. With an EC50 value of 0.25 μM, this compound successfully restores gene expression that has been down-regulated by RUNX1/ETO. Furthermore, RUNX1/ETO tetramerization-IN-1 demonstrates promising anti-leukemic activity by inhibiting the proliferation of SKNO-1 cells dependent on RUNX1/ETO and significantly reducing RUNX1/ETO-associated tumor g... | |||
T73547 | CPUL1 | ||
CPUL1 是一种TrxR 抑制剂,对 A549 细胞显示出增殖抑制和抗转移活性。CPUL1 通过抑制TrxR1酶活性来诱导 ROS 介导的ERK/JNK 信号传导从而影响上皮-间质转化 (EMT)。CPUL1 与α-Lipoic Acid 或Dithiodipropionic acid 联合使用效果更好。 | |||
T73529 |
AS-99
|
||
AS-99 是首创的、有效的、选择性 ASH1L 组蛋白甲基转移酶抑制剂 (IC50= 0.79 µM,Kd= 0.89 µM),并具有抗白血病活性。AS-99 阻断细胞增殖,诱导细胞凋亡 (apoptosis) 和细胞分化,下调 MLL 融合靶基因,减少体内白血病负担。 | |||
T36978 | AS-99 TFA | ||
AS-99 TFA is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 μM, Kd= 0.89 μM) with anti-leukemic activity. AS-99 TFA blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo[1]. AS-99 TFA is tested against a panel of 20 histone methyltransferases, including NSD1, NSD2, NSD3, and SETD2. NO significant inhibition is observed at 50 μM of AS-99 TFA on any of the tested... | |||
T78159 | ATIC-IN-1 acetate | Others | Others |
ATIC-IN-1 (compound 14) acetate 是针对氨基咪唑甲酰胺核糖核苷酸转化酶/肌苷一磷酸环化水解酶 (ATIC) 的抑制剂,其Ki值为685 nM。该化合物阻碍ATIC二聚体的形成,此过程对于其转化酶活性中氨基咪唑甲酰胺核糖核苷酸 (AICAR) 的催化至关重要。ATIC-IN-1 acetate 显示出降低细胞数量及细胞分裂率的抗肿瘤效果。 | |||
T74893 | EGCG-4″-sulfate | ||
EGCG-4″-sulfate,作为绿茶中的主要多酚成分,具有抑制细胞增殖和诱导细胞凋亡的功能。它通过抑制谷氨酸脱氢酶1/2(GDH1/2, GLUD1/2)活性,发挥作用。此外,EGCG-4″-sulfate在对抗结直肠癌、髓性白血病、甲状腺癌等多种癌症中显示出显著的抗癌、抗氧化和抗炎效果[2]。 | |||
T63071 |
CDK6/PIM1-IN-1
|
||
CDK6/PIM1-IN-1 是一种平衡的、有效的、双重 CDK6 (IC50: 39 nM) 和 PIM1 (IC50: 88 nM) 抑制剂。CDK6/PIM1-IN-1 对 CDK4 表现出抑制作用,其 IC50 值为 3.6 nM。CDK6/PIM1-IN-1 能够明显抑制急性髓系白血病 (AML) 细胞增殖,将细胞周期阻滞在 G1 期并诱导细胞凋亡。CDK6/PIM1-IN-1 表现出抗 AML 活性。 | |||
T37495 |
Angiotensin (1-7) (acetate)
|
||
Angiotensin 1-7 (Ang-(1-7)) acetate 是RAS中的一种内源性七肽,具备心脏保护作用,主要表现为对心肌细胞的抗炎与抗纤维化活性。该化合物能抑制纯化的犬ACE活性(IC50=0.65 μM),通过降低ACE活性并促进一氧化氮释放,作为血管舒张调节的局部协同因子。此外,Angiotensin 1-7 acetate 可阻止血管紧张素Ⅱ诱发的平滑肌细胞增殖和肥大,同时对内皮细胞表现出抗血管生成和生长抑制作用。 | |||
T72780 |
HSP90/mTOR-IN-1
|
||
HSP90/mTOR-IN-1 是一种有效的Hsp90和mTOR 抑制剂,IC50分别为 69 nM 和 29 nM。HSP90/mTOR-IN-1 通过过度激活PI3K/AKT/mTOR 通路抑制 SW780 细胞增殖。HSP90/mTOR-IN-1 通过对HSP90和mTOR 的选择性抑制来诱导细胞凋亡 (apoptosis) 和细胞自噬 (autophagy)。HSP90/mTOR-IN-1 在异种移植小鼠体内也表现出良好的抗肿瘤活性。HSP90/mTOR-IN-1 可用于膀胱癌的研究。 | |||
T36713 |
Streptochlorin
|
||
Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp. SF2583 that has diverse biological activities, including antiangiogenic, antiproliferative, and anti-allergic properties. It inhibits TNF-α-induced NF-κB transcriptional activity and decreases proliferation of human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 5 to 20 μM. Streptochlorin (12 μg/ml) decreases viability of, as well as induces apoptosis and increases the productio... | |||
T79714 |
HDAC3-IN-2
|
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
HDAC3-IN-2 (compound 4i) 是一种具有纳摩尔级效力的吡嗪酰肼基HDAC3抑制剂,IC50值为14 nM,针对三阴性乳腺癌细胞表现出高效抑制作用。该化合物在细胞内毒性测定中显示,对4T1细胞株的IC50为0.55 μM,对MDA-MB-231细胞株的IC50为0.74 μM。HDAC3-IN-2通过增加乙酰化水平(如H3K9、H3K27和H4K12),促进细胞凋亡(涉及caspase-3、caspase-7和细胞色素c的水平提升),并抑制细胞增殖相关蛋白(如Bcl-2、CD44、EGFR和Ki-67)的表达,从而在荷瘤小鼠模型中表现出显著的体内抗肿瘤作用。 | |||
T36882 |
CAY10773
|
||
CAY10773 is a derivative of the ferroptosis inducer sorafenib .1It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 μM, respectively) over non-cancerous HCV-29 cells (IC50= 23.19 μM). CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 μM but induces ferroptosis at concentrations greater than or equal to 6 μM with 10 hour or longer incubation times. It increases the production of reactive oxygen ... | |||
T36084 |
PKI-179
|
||
PKI-179 is a potent and orally active dual PI3K/mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α, PI3K-β, PI3K-γ, PI3K-δ and mTOR, respectively. PKI-179 also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKI-179 shows anti-tumor activity in vivo[1][2]. PKI-179 inhibits the cell proliferation, with IC50s of 22 nM and 29 nM for MDA361 and PC3 cells, respectively[1].PKI-179 shows inhibitory activity against a panel of 361 other ... | |||
T36684 | Ipivivint | ||
Ipivivint, a first-in-class, orally active and potent CDC-like kinase (CLK) inhibitor, inhibits CLK1 (IC50=1.4 μM), CLK2 (IC50=0.002 μM) and CLK3 (IC50=0.022 μM). Ipivivint reduces Wnt pathway signaling gene expression through inhibiting CLK activity and serine and arginine rich splicing factor (SRSF) phosphorylation and disrupting spliceosome activity. Ipivivint can be used for the research of cancer[1]. Ipivivint (SW480 cells; 0.01~10 μM; 1 hour) potently inhibits SRSF5/6 phosphorylation[1].Ip... | |||
T37604 | ITK inhibitor | ||
Interleukin-2-inducible T cell kinase (ITK) is a non-receptor tyrosine kinase expressed in T cells, NKT cells and mast cells which plays a crucial role in regulating the T cell receptor (TCR), CD28, CD2, chemokine receptor CXCR4, and FcepsilonR-mediated signaling pathways. ITK inhibitors can be used for the treatment of inflammation and immune-mediated disorders. ITK inhibitor (N-[5-[[3-[(4-Acetylpiperazin-1-yl)carbonyl]-4-methyl-6-methoxy-phenyl]thio]thiazol-2-yl]-4-(N-1,2-dimethylpropylaminome... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0687 |
Simvastatin
辛伐他汀,MK-0733,MK 733 |
Apoptosis; Mitophagy; Ferroptosis; HMG-CoA Reductase; Autophagy | Apoptosis; Autophagy; Metabolism |
Simvastatin (MK 733) 是一种 HMG-CoA 还原酶抑制剂 (Ki=0.2 nM),具有口服活性。Simvastatin 具有降血脂活性,可以抑制肝脏产生胆固醇,还可以用于预防心血管疾病。 | |||
T12581 |
Puerarin-4'-O-β-D-glucopyranoside
Puerarin4'-O-glucoside,葛根素-4'-Β-D-葡萄糖苷 |
Others | Others |
Puerarin-4'-O-β-D-glucopyranoside (Puerarin4'-O-glucoside) 是一种从葛根 (PLR) 中提取的异黄酮。它具有雌激素活性和抗 MCF-7 人乳腺癌细胞增殖作用。 | |||
TN2233 |
Spathulenol
|
Antioxidant; Antifungal | Microbiology/Virology; oxidation-reduction |
Spathulenol 是一种来自 Aristolochia yunnanensis 的天然成分,具有抗炎、抗氧化、抗增殖、抗溃疡和抗分枝杆菌活性。 Spathulenol 在 DPPH 系统中显示出显著的抗氧化活性,IC50 为 85.60 μg/mL。 | |||
T5S1882 |
Songorine
准葛尔乌头碱,Napellonine,Zongorine,Bullatine G |
Others; GABA Receptor | Membrane transporter/Ion channel; Neuroscience; Others |
Songorine (Napellonine) 是从乌头属中分离出的一种二萜生物碱,具有抗癌、抗心律不齐和抗炎活性。它是大鼠脑中的GABAA 受体拮抗剂,有用于上皮性卵巢癌的研究潜力。 | |||
T5S0777 |
Phellodendrine chloride
|
Others | Others |
Phellodendrine chloride 是一种Phellodendron amurense 中的生物碱。它通过巨胞饮抑制营养物质的吸收,进而抑制 KRAS 突变的胰腺癌细胞的增殖。 | |||
T3398 |
Icaritin
Anhydroicaritin,去水淫羊藿黄素,Cycloicaritin |
Apoptosis; JAK; STAT; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
Icaritin (Anhydroicaritin) 是Epimedium Genusis 的异戊二烯类黄酮衍生物,有效抑制 K562 细胞和原代 CML 细胞的增殖。它可以调节MAPK/ERK/JNK 和JAK2/STAT3/AKT 信号传导,并具有增强成骨的作用。 | |||
TN1516 |
Cnidicin
蛇床素,4,9-双[(3-甲基-2-丁烯-1-基)氧基]-7H-呋喃并[3,2-G][1]苯并吡喃-7-酮 |
NOS; NO Synthase | Immunology/Inflammation |
Cnidicin 是一种香豆素,对肥大细胞脱颗粒及 RAW 264.7 细胞产生一氧化氮具有抑制作用。 | |||
T6S0781 |
Phellodendrine
黄柏碱,Phallodendrin |
Others; NF-κB; Akt | Cytoskeletal Signaling; NF-κB; Others; PI3K/Akt/mTOR signaling |
Phellodendrine (Phallodendrin) 是异喹啉生物碱,是黄柏皮层中的重要特征成分之一。它具有良好的抗氧化,抗炎作用。它通过调节AKT/NF-κB 途径抵抗 AAPH 诱导的氧化应激。 | |||
T3411 |
Curdione
莪术二酮,(+)-Curdione |
P450 | Metabolism |
Curdione ((+)-Curdione) 是一种具有高生物活性的倍半萜类物质,从莪术中分离获得,具有抑制血小板聚集、抵抗血栓形成的作用。 | |||
T4S0999 |
(2S)-Isoxanthohumol
Isoxanthohumol,(2S)-异黄腐酚,异黄腐醇 |
Virus Protease; HSV | Microbiology/Virology |
(2S)-Isoxanthohumol 是一种由啤酒花原异戊烯基二氢黄酮 Isoxanthohumol 的微生物转化代谢物。 | |||
TJS0487 |
(-)-Syringaresinol
DL-Syringaresinol,Lirioresinol b,(-)-丁香脂素 |
Others | Others |
(-)-Syringaresinol (DL-Syringaresinol) 来源于番荔枝 Annona Montana 的茎。 (-)-Syringaresinol 通过 G1 期阻滞和诱导细胞凋亡来抑制人早幼粒细胞 HL-60 细胞的增殖,并具有抗癌活性。 | |||
T3S1513 |
(20R)-Protopanaxadiol
Protopanaxadiol,20R-Protopanaxadiol,(20R)-原人参二醇,(20R)-Protopanaxdiol |
Others; Antibacterial | Microbiology/Virology; Others |
(20R)-Protopanaxadiol ((20R)-Protopanaxdiol) 是黑参中20(R)-人参皂甙 Rg3的一种三萜皂苷代谢物。它抑制幽门螺杆菌的生长,有抗肿瘤活性和细胞毒性。 | |||
TN1805 |
Isosilybin B
|
Apoptosis; Androgen Receptor | Apoptosis; Endocrinology/Hormones |
Isosilybin B 是一种从水飞蓟中提取的黄酮木脂素,具有抗前列腺癌 (PCA) 活性,对癌细胞增殖有抑制作用,促使 G1 期阻滞和凋亡。Isosilybin B 诱导雄激素受体降解。 | |||
TN2089 |
Platycodin D3
桔梗皂苷D3,桔梗皂苷 D3 |
HCV Protease; NF-κB | Microbiology/Virology; NF-κB; Proteases/Proteasome |
Platycodin D3 是桔梗中有抗HCV 活性的一种三萜皂苷类天然产物。 | |||
T4518 |
Licochalcone D
|
ERK; NF-κB | MAPK; NF-κB |
Licochalcone D 是一种 NF-κB p65的有效抑制剂,是一种存在于 Glycyrrhiza inflate 中的黄酮类化合物,具有抗氧化、抗炎、抗癌等作用。 | |||
TN3972 |
Epimedokoreanin B
|
Apoptosis; Others; Antibacterial | Apoptosis; Microbiology/Virology; Others |
Epimedokoreanin B (EKB) 是一种从韩国淫羊藿中分离出的异戊烯化类黄酮,在人非小细胞肺癌(NSCLC)A549和NCI-H292细胞中展现出抗癌活性。Epimedokoreanin B 还具有抗炎和抗菌活性,可有清除 DPPH 自由基的活性,能以剂量依赖的方式抑制 MCF-7 和 HepG2 的增殖。Epimedokoreanin B 能显著抑制 N (δ) -(羧甲基)赖氨酸(CML)和 N (Ï) -(羧甲基)精氨酸(CMA)的形成,可通过抑制高级糖化终产物(AGEs)预防糖尿病的临床并发症。 | |||
TN6967 |
(R)-Isomucronulatol
(-)-Isomucronulatol,2H-1-Benzopyran-7-ol |
Apoptosis | Apoptosis |
(R)-Isomucronulatol (2H-1-Benzopyran-7-ol) 是一种可从黄芪、刺槐、虎杖和甘草叶片中提取得到的类黄酮,抑制BMSCs 在TNF-α微环境中的增殖和凋亡。(R)-Isomucronulatol 具有潜在的抗炎活性。 | |||
T2P2806 |
Hederacolchiside A1
黑海常春藤苷A1,革叶常春藤皂苷 A1,Raddeanoside R13 |
Apoptosis; ERK; MEK; Akt; PI3K; Parasite; mTOR | Apoptosis; Cytoskeletal Signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling |
Hederacolchiside A1 (Raddeanoside R13) 是从白头翁中分离的一种有抗利什曼原虫和抗肿瘤增殖活性的天然产物。 | |||
T3824 |
Jaceosidin
|
Apoptosis; BCL; COX; UGT | Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience |
Jaceosidin 是从毛莲蒿中得到的一种黄酮类天然产物,可激活Bax,下调 Mcl-1 和 c-FLIP 的表达,诱导癌细胞凋亡。它能够降低炎性因子水平,激活 NF-κB,抑制COX-2的表达,具有抗癌和抗炎作用。 | |||
T3776 |
Rhapontigenin
丹叶大黄素,Protigenin |
P450; Antibacterial; Antifungal | Metabolism; Microbiology/Virology |
Rhapontigenin (Protigenin) 是一种基于机制的选择性细胞色素 P450 1A1 (IC50: 400 nM) 灭活剂。它是一种芳烃羟化酶,可激活作为致癌物质的多环芳烃。它是白藜芦醇的天然类似物,具有抗癌,抗氧化剂,抗真菌和抗菌活性。 | |||
T7027 |
EURYCOMANONE
东革阿里提取物,Pasakbumin A |
Others | Others |
Eurycomanone (Pasakbumin A) 能够抑制雌激素生成过程中磷酸二酯酶和芳香酶的活性,促进精子生成。它对 HepG2 细胞具有细胞毒性,能够上调 p53 和 Bax 以及下调 Bcl-2 ,诱导细胞凋亡。它具有抗癌活性,在浓度范围内以剂量依赖性方式抑制 A549 肺癌细胞增殖 从 5 到 20 微克/毫升。 | |||
T6S0119 |
Dauricine
蝙蝠葛碱 |
Apoptosis; Others; NF-κB | Apoptosis; NF-κB; Others |
Dauricine 是存在于北豆根粉末中的一种双苯异喹啉生物碱,具有抗炎活性。它通过抑制NF-κB 激活,剂量依赖性地抑制结肠癌细胞的增值和侵袭,并诱导凋亡。 | |||
T4900 |
(±)-Methyl Jasmonate
(±)-茉莉酸甲酯,甲基茉莉酮酸酯,(±)-Jasmonic Acid methyl ester,Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate |
Others; Endogenous Metabolite | Metabolism; Others |
Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate ((±)-Jasmonic Acid methyl ester) 是内源性代谢产物的一种。 | |||
TN6872 |
Trypsin
|
Protease-activated Receptor | GPCR/G Protein |
Trypsin 是一种可从鱼类分离出的丝氨酸蛋白酶,可水解赖氨酸或精氨酸羧基侧蛋白质。Trypsin 具有抗炎活性,可通过 PDCoV 的 S 糖蛋白与 pAPN 的相互作用诱导 PDCoV 感染的细胞膜融合,可激活 PAR2 和 PAR4,促进细胞增殖和分化。Trypsin 可用于促进伤口愈合和研究神经源性炎症。 | |||
T2S2215 |
Crebanine
|
Apoptosis; Others; Akt | Apoptosis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling |
Crebanine 是来自于韦诺萨千金藤的一种生物碱,通过抑制 MAPKs 和 Akt 信号通路表现出抗炎活性,还具有抗心律失常的作用。它可诱导人类癌细胞的 G1阻滞和凋亡。 | |||
TN2106 |
Protodeltonin
原三角叶皂苷 |
BCL; PARP; Caspase | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome |
Protodeltonin may have anti-thrombotic activity by both improving the anticoagulation activity and inhibiting platelet aggregation action. Protodeltonin can inhibit the proliferation of a panel of established human and murine cancer cell lines in vitro. | |||
TN3461 |
Asebotin
|
Influenza Virus | Microbiology/Virology |
Asebotin shows anti-influenza A virus activity, it also possesses potent antiviral activity (100% inhibition at the concentration of 1 ug /mL) against highly pathogenic avian influenza strain H5N1. Asebotin can inhibit the proliferation of murine B cells. | |||
TN4356 |
Jolkinolide A
|
Akt; STAT; mTOR | Cytoskeletal Signaling; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Stem Cells |
Jolkinolide A has anti-tumor activity. It inhibited VEGF expression in A549 cells through the inhibition of the Akt-STAT3-mTOR signaling pathway, and directly inhibited the proliferation and migration of HUVECs. | |||
TN5593 | Euphohelioscopin A | ||
Euphohelioscopin A, an activator of protein kinase C (PKC), it inhibits proliferation and induces differentiation of the myeloid leukemia cell lines THP-1 and HL-60. Euphohelioscopin A has anti-inflammary activity, it exhibits moderate inhibitory activity | |||
TN4716 |
Oplodiol
|
Influenza Virus | Microbiology/Virology |
Oplodiol exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strains. Oplodiol has a stimulative effect on significantly proliferation and differentiation of culture osteoblasts; it also shows moderate cytotoxic effects on the human | |||
TN4490 | Manassantin B | ERK; BCL; p38 MAPK; TNF; NF-κB; JNK; STAT; Antifection | Apoptosis; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; Stem Cells |
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-EBV lytic replication activity. Manassantin B inhibits interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells, it has potential as a potent anti-inflammatory drug for use in pathological processes such as sepsis or acute lung injury. Manassantin B exerts antifibrotic activity in HSC-T6 cells, in pa... | |||
T75634 | Demycarosyl-3D-β-D-digitoxosylmithramycin SK | ||
Demycarosyl-3D-β-D-digitoxosylmithramycin SK 为Mithramycin类似物,展现出显著的抗肿瘤活性。该化合物通过与DNA结合蛋白结合并抑制其功能,有效阻断肿瘤细胞的增殖与生长。 | |||
TN4604 | Myricanone | BCL; HSP; NF-κB; ROS; Caspase; STAT | Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Metabolism; NF-κB; Proteases/Proteasome; Stem Cells |
Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation by down-regulation of NF-κB and STAT3 signalling cascades. Myricanone shows in vitro testost | |||
TN4471 |
Lysicamine
|
IL Receptor; Antifection | Immunology/Inflammation; Microbiology/Virology |
Lysicamine shows significant antioxidant capacity in the ORAC(FL) assay and it is active against S. epidermidis and C. dubliniensis, with MIC values in the range 12.5-100 microg mL(-1). Lysicamine has antimicrobial and anti-inflammation activity, the mini | |||
TN4168 | Grifolin | Others | Others |
Grifolin has anti-cancer effects, it induces apoptosis and promotes cell cycle arrest in the A2780 human ovarian cancer cell line via inactivation of the ERK1/2 and Akt pathways; it enhances the differentiation and proliferation of oligodendrocyte precurs | |||
TN3706 |
Coronarin A
|
||
Coronarin, A, B, C, and D are cytotoxic prinicples from the rhizomes of Hedychium coronarium, Zingiberaceae. Coronarin A exhibits good growth inhibition activities on HUVEC proliferation, it effectively suppresses the growth factor induced tube formation | |||
TN5164 |
trans-Hinokiresinol
|
IL Receptor; TNF; NOS; LTR | Apoptosis; Immunology/Inflammation |
Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction. Hinokiresinol (trans-hinokiresinol) and nyasol (cis-hinokiresinol) are estrogen | |||
TN3364 |
Agrimonolide
|
Apoptosis; Dehydrogenase; p38 MAPK; ROS; JAK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; MAPK; Metabolism; Stem Cells |
Agrimonolide 是一种来自异香豆素的化合物,主要存在于草药Agrimonia pilosa Ledeb 中,具有显著的生物活性。Agrimonolide 通过抑制脂多糖(LPS)诱导的JAK-STATs 和p38 MAPKs 信号通路的激活而发挥抗炎作用。Agrimonolide 及其衍生物去甲阿戈莫内德已显示出能够有效提高肝细胞中胰岛素介导的糖原水平,可能在调节胰岛素抵抗的HepG2细胞中发挥关键作用。Agrimonolide 通过靶向卵巢癌细胞中的SCD1,对癌症的进展和诱导细胞死亡和凋亡表现出抑制作用。特别是,Agrimonolide 对A2780和SKOV-3细胞的增殖、迁移和侵袭表现出剂量依赖性的抑制,同时促进细胞凋亡。该化合物还被发现能诱导铁介导的细胞死亡,同时增加活性氧(ROS)和总铁的水平。Agrimonolide 很容易穿过血脑屏障,表明其在神经系统疾病的治疗应用方面具有潜力。 |