901
36
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T40130 |
Nur77 modulator 1
Nur77 modulator 1 |
Others | Others |
Nur77 modulator 1 可与Nur77结合,KD 为 3.58 μM。它上调 Nur77 表达,介导Nur77亚细胞定位,诱导Nur77 依赖的内质网应激和自噬,可导致细胞凋亡,Nur77 modulator 1显示出抗肝癌生物活性。 | |||
T21083 |
TFIIH Modulator-19
TFIIH Modulator19,TFIIH Modulator 19 |
Others | Others |
TFIIH Modulator-19 诱导毛发硫营养不良组 A 蛋白的二聚化以调节 TFIIH 转录活性。 | |||
T60063 |
Fluorogen binding modulator-1
Fluorogen binding modulator-1 |
Others | Others |
Fluorogen binding modulator-1 (Fluorogen binding modulator-1)是一种氟-氟激活蛋白结合对的非荧光抑制剂。 | |||
T40279 |
GLP-1R modulator L7-028
GLP-1R modulator L7-028 |
cAMP; Glucagon Receptor | GPCR/G Protein |
GLP-1R modulator L7-028 是一种变构调节剂,增强了对 GLP-1 的亲和力和 cAMP 信号转导。 | |||
T40997 |
GLP-1R modulator C16
GLP-1R modulator C16 |
Glucagon Receptor | GPCR/G Protein |
GLP-1R modulator C16 是一种变构调节剂,显著增加了 GLP-4 的结合亲和力。 | |||
T10696 |
CB2 modulator 1
|
Cannabinoid Receptor | GPCR/G Protein |
CB2 modulator 1 是一种有效的 CB2 调节剂。 可用于免疫疾病、骨质疏松症、炎症、肾缺血的研究。 | |||
T12922 |
Sirtuin modulator 1
SRT3025 Hydrochloride |
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Sirtuin modulator 1 (SRT3025 Hydrochloride) 是 SIRT1 的调节剂,EC1.5 < 1 μM。 | |||
T12821 |
S1PR1 modulator 1
|
LPL Receptor | GPCR/G Protein |
S1PR1 modulator 1 是 S1PR1 的特异性抑制剂,pIC50 为 7.6。 | |||
T10168 |
5-HT1A modulator 1
5-HT1Amodulator1 |
Phospholipase; Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor | GPCR/G Protein; Metabolism; Neuroscience |
5-HT1A modulator 1 对 5-HT1A、α1-肾上腺素能受体和 D2 受体具有非常高的亲和力(IC50s = 2 nM、10 nM 和 40 nM)。 | |||
T11458 |
GPR40/FFAR1 modulator 1
|
GPR | Endocrinology/Hormones; GPCR/G Protein |
GPR40/FFAR1 modulator 1是一种针对Gq偶联的游离脂肪酸受体1 (GPR40/FFAR1) 的激动剂以及异构调节剂。 | |||
T36526 |
IL-17 modulator 4
|
Interleukin | Immunology/Inflammation |
IL-17 modulator 4 是 IL-17 modulator 1 的前药,IL-17 modulator 1 是 IL-17 的有效调节剂。 | |||
T37734 |
AMPA receptor modulator-2
|
GluR | Neuroscience |
AMPA receptor modulator-2 是 AMPA 受体的有效调节剂,在 TARPγ2 依赖性 AMPA 受体上的pIC50为 10.1。 | |||
T9999 |
Sirtuin modulator 2
N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide |
Others; Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair; Others |
Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) 具有抗糖尿病、抗炎和抗肿瘤活性。 | |||
T67747 |
CB2R/FAAH modulator-3
|
Cannabinoid Receptor; FAAH | GPCR/G Protein; Metabolism; Neuroscience |
CB2R/FAAH modulator-3 (compound 27) 是一种双重靶点的调节剂,是 CB2R 的激动剂, 也是FAAH 的抑制剂, 作用于 CB2R 和 CB1R 的 Ki 值分别是 20.1 和 67.6 nM,作用于 FAAH 的IC50值为 3.4 μM。CB2R/FAAH modulator-3 可用于癌症、神经退行性疾病中发生的有害炎症级联反应以及 COVID-19 感染相关研究。 | |||
T67832 |
ALDH2 modulator 1
|
Dehydrogenase | Metabolism |
ALDH2 modulator 1 是一种有效的且具有口服活性的乙醛脱氢酶-2 (ALDH2)调节剂。ALDH2 modulator 1 可使小鼠血液中的酒精含量降低。 | |||
T67884 |
β-catenin modulator IIa-661
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
β-catenin modulator IIa-661是 Wnt 途径小分子抑制剂,具有抗肿瘤活性。 | |||
T8824 |
CRBN modulator-1
WUN29654 |
Others; Ligand for E3 Ligase | Others; PROTAC |
CRBN modulator-1 (WUN29654) 是一种 Thalidomide 类似物。它是一种 CRBN 调节剂,结合 CRBN 的 IC50=3.5 μM,Ki=0.98 μM。 | |||
T10101 |
Calcium channel-modulator-1
|
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Calcium channel-modulator-1是钙离子通道调节剂(IC50:0.8 μM),具有阻塞主动脉收缩的专业化。 | |||
T37197 |
5-HT1A modulator 2 hydrochloride
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
5-HT1A modulator 2 hydrochloride 是 8-OH-DPAT 的一种衍生物,是5-HT1A 的调节剂,Ki 为 53 nM。 | |||
T67745 |
CB2R/FAAH modulator-2
|
Cannabinoid Receptor; FAAH | GPCR/G Protein; Metabolism; Neuroscience |
CB2R/FAAH modulator-2 (compound 26) 是一种双重靶点的调节剂,是 CB2R 的激动剂,也是 FAAH 的抑制剂,作用于 CB2R 和 CB1R 的 Ki 值分别是 10.8 和 152.9 nM,作用于FAAH 的 IC50 值为 6.2 μM。CB2R/FAAH modulator-2 可用于癌症、神经退行性疾病中发生的有害炎症级联反应以及 COVID-19 感染相关研究。 | |||
T15249 |
Estrogen receptor modulator 1
|
Estrogen Receptor/ERR | Endocrinology/Hormones |
Estrogen receptor modulator 1 是一种有效的、具有口服活性的、选择性雌激素受体(estrogen receptor)调节剂 (SERM),其 pIC50为 0.46。它能够诱导 Tamoxifen 耐药、激素非依赖性异种移植瘤的消退。 | |||
T10307 |
AMPA receptor modulator-1
|
iGluR | Membrane transporter/Ion channel; Neuroscience |
AMPA receptor modulator-1可被谷氨酸激活,从而调节离子通道。 | |||
T11358 |
gamma-secretase modulator 1
N-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-4-phenyl-4,5,6,7-tetrahydro-1,3-benzothiazol-2-amine |
Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
gamma-secretase modulator 1 是一种 γ 分泌酶的调节剂,可用于治疗阿尔茨海默病的研究。 | |||
T67896 |
CB2R/FAAH modulator-1
|
Cannabinoid Receptor; FAAH | GPCR/G Protein; Metabolism; Neuroscience |
CB2R/FAAH modulator-1是一种大麻素2型受体(CB2R)激动剂,同时也是脂肪酸酰胺水解酶(FAAH)抑制剂(IC50=4 μM),可减少促炎和增加抗炎细胞因子的产生,常用于炎症研究。对 CB2R 和 CB1R 的Kis 分别为14.8 nM 和241.3 nM。 | |||
T12247 |
NOT Receptor Modulator 1
2-(3-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl)phenyl)propan-2-ol |
Others | Others |
NOT Receptor Modulator 1 (2-(3-(2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl)phenyl)propan-2-ol) 是核受体 NOT 调节剂。 | |||
T9970 |
mGluR3 modulator-1
1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile,1-乙基-3-(1,4-氧杂氮杂环己-4-基)-5,6,7,8-四氢异喹啉-4-甲腈 |
GluR | Neuroscience |
mGluR3 modulator-1 (1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile) 是 mGluR3 的正变构调节剂,可用于治疗帕金森病的研究。 | |||
T15942 |
MK-7622
M1 receptor modulator |
AChR | Neuroscience |
MK-7622 (M1 receptor modulator) 是毒蕈碱 M1 受体阳性变构的调节剂。 | |||
T67742 |
EX-A5386
Glucocorticoid receptor modulator-1 |
Glucocorticoid Receptor | Endocrinology/Hormones |
EX-A5386 (Glucocorticoid receptor modulator-1)是一种有效的糖皮质激素受体调节剂,IC50/EC50<100nM。 | |||
T6679 |
SRT 2104
SRT2104,sirtuin modulator,GSK2245840 |
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
SRT 2104 (GSK2245840) 是一种高度选择性、可通过血脑屏障的 Sirt1激活剂,依赖于 NAD+,增加 Sirt1 蛋白水平,用于糖尿病和亨廷顿氏症的研究。 | |||
T24727 |
ROR Modulator I
ROR-Modulator-I,RORModulatorI |
||
ROR Modulator I is the first potent inverse agonist of the retinoid-related orphan receptor. It also has dual selectivity for RORβ and RORγt. | |||
T10765 |
Eragidomide
CC-90009,Cereblon modulator 1 |
Apoptosis; Ligand for E3 Ligase; Molecular Glues | Apoptosis; PROTAC |
Eragidomide (CC-90009; Cereblon modulator 1) 是一种 GSPT1 选择性 cereblon (CRBN)E3 连接酶调节剂,以分子胶的方式作用。Eragidomide 通过 CRL4CRBN 选择性靶向 GSPT1 进行泛素化和蛋白酶体降解。 | |||
T4050 |
GSK2981278
ROR gama modulator 1 |
ROR | Metabolism |
GSK2981278 (ROR gama modulator 1) 是 RORγ的选择性反向激动剂。它能够抑制 il17启动子的激活,并且干扰 RORγ-DNA 结合。 | |||
T39694 |
GluN2B receptor modulator-1
GluN2B receptor modulator-1 |
||
GluN2B receptor modulator-1 is a potent and selective allosteric modulator of the GluN2B receptor. It demonstrates negative modulation, inhibiting receptor activity, and exhibits high selectivity towards the GluN2B subunit, with an impressive IC50 value of 31 nM. | |||
T21082 |
2,5-Dihydroxybiphenyl
TFIIH Modulator 12,2,5-二羟基联苯,TFIIH Modulator12 |
Others | Others |
2,5-Dihydroxybiphenyl (TFIIH Modulator12) 是一种小分子去稳定诱导剂,可诱导毛发硫营养不良组 A 蛋白的二聚化,从而调节 TFIIH 转录活性。 | |||
T27951 |
LY392098
LY-392098,LY 392098,AMPA receptor modulator-3 |
GluR; iGluR | Membrane transporter/Ion channel; Neuroscience |
LY392098 (AMPA receptor modulator-3) 是 AMPA 受体的变构调节剂,EC50 为 4.4 μM,可用于哺乳动物神经系统的研究。 | |||
T36291 | Integrin modulator 1 | ||
Integrin modulator 1 is a potent and selective α4β1 integrin agonist, with an IC50 of 9.8 nM for RGD-binding α4β1. Integrin modulator 1 increases cell adhesion mediated by α4β1 integrin, with an EC50 of 12.9 nM[1]. Integrin modulator 1 (2-10 μg/mL; 30 min) significantly increases Jurkat E6.1 cell adhesion[1].Integrin modulator 1 (1-100 nM; 1 h) strongly and significantly increases ERK1/2 phosphorylation in Jurkat E6.1 cells[1].Integrin modulator 1 (1 nM-10 μM; 30 min) significantly increases the... | |||
T61483 |
GLP-1R modulator C5
|
Glucagon Receptor | GPCR/G Protein |
GLP-1R modulator C5 是一种小分子 GLP-1R 正变构调节剂,通过跨膜位点增强GLP-1与GLP-1R的结合,可用于研究 II 型糖尿病。。 | |||
T38659 |
mGluR5 modulator 1
|
||
mGluR5 modulator 1 is a compound that acts as a positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). Its primary application lies in the field of schizophrenia and cognitive impairment research. | |||
T40893 |
Estrogen receptor modulator 6
|
||
Estrogen receptor modulator 6 (compound 3a) is a highly specific and potent agonist of the estrogen receptor (ER) β with a remarkable affinity (K i = 0.44 nM). This compound exhibits an impressive 19-fold selectivity for ERβ over ERα, as evidenced by its affinity (K i = 8.4 nM). | |||
T40315 | γ-Secretase modulator 10 | ||
γ-Secretase modulator 10 is a novel γ-secretase modulator. | |||
T40127 |
IL-17 modulator 3
|
||
IL-17 modulator 3 (US20200247785A1) is a chemical compound that acts as an IL-17 modulator. It has potential applications in researching inflammation, cancer, and autoimmune diseases. | |||
T11358L |
gamma-secretase modulator 1 hydrochloride
gamma-secretase modulator 1 hydrochloride (1172637-87-4 free base) |
Others | Others |
gamma-secretase inhibitior-1 是γ-secretase 调节剂,gamma-secretase inhibitior-1可用于阿尔茨海默病。 | |||
T62204 |
NR2F6 modulator-1
|
Others | Others |
NR2F6 modulator-1 是一种核受体亚族 2,F 组第 6 号成员 (NR2F6) 的有效调节剂。NR2F6 modulator-1 能够用于研究免疫调节和肿瘤干细胞活性的调节。 | |||
T40355 | IL-17A modulator-2 | ||
IL-17A modulator-2, exhibits inhibitory properties towards IL-17A, with a pIC50 of 8.3. Its effectiveness lies in attenuating the biological effects associated with IL-17A activity. IL-17A modulator-2 finds utility in the study of diseases and disorders characterized by dysregulated IL-17A modulation, such as those involving immune dysfunction, autoimmune pathology, cancer, and neurodegenerative conditions. | |||
T36525 |
IL-17 modulator 1 disodium
|
||
IL-17 Modulator 1 (disodium) is a potent, orally active compound, known for its high efficacy in modulating IL-17. This compound is extensively utilized for researching various diseases such as psoriasis, ankylosing spondylitis, and psoriatic arthritis[1]. | |||
T40106 | IL-17 modulator 1 | ||
IL-17 modulator 1 is an orally active small molecule. It is highly efficacious in modulating IL-17 and can effectively prevent, treat, or ameliorate various diseases such as psoriasis, ankylosing spondylitis, and psoriatic arthritis. | |||
T40354 |
IL-17A modulator-1
|
||
IL-17A modulator-1 is an effective inhibitor of IL-17A activity, exhibiting a pIC 50 value of 8.2. This compound holds great promise for studying diseases and disorders that involve the modulation of IL-17A, such as immune-related diseases, autoimmune pathologies, cancer, and neurodegenerative disorders. | |||
T11790 |
Kv3 modulator 4
|
Others | Others |
Kv3 modulator 4 is a Kv3.1 (pEC50=5.45) and Kv3.2 modulator .Cyclobutyl structure. | |||
T11788 | Kv3 modulator 2 | Others | Others |
Kv3 modulator 2 is a potent Kv3 channels modulator.has analgesic activity and is used in the prophylaxis or treatment of related disorders. | |||
T10906 | CXCR7 modulator 1 | Others | Others |
CXCR7 modulator 1 is an effective and orally bioavailable peptoid hybrid CXCR7 modulator with Ki of 9 nM. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0983 |
Penicillamine
青霉胺,d-penicillamin,Dimethyl Cysteine,D-青霉胺,Artamine,D-(-)-Penicillamine |
Antibiotic | Microbiology/Virology |
Penicillamine (Artamine) 是一种 penicillin 的代谢降解产物,是一种螯合剂,可作用于威尔逊氏病。 | |||
T22644 |
C2 Ceramide
Ceramide |
Others | Others |
A potent modulator of cell proliferation and differentiation. | |||
T3S2019 |
Lathyrol
|
Others | Others |
Lathyrol 是一种具有抗癌功能的天然产物。 | |||
T10233 |
Acetylarenobufagin
|
HIF | Angiogenesis; Chromatin/Epigenetic |
Acetylarenobufagin 是一种类固醇缺氧诱导因子-1 (HIF-I) 调节剂。 | |||
TN6773 |
Acetoxyvalerensre
acetylvalerenolic acid |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Acetoxyvalerensre (acetylvalerenolic acid) 是缬草酸的衍生物,它是一种 GABAA 受体调节剂。 | |||
TQ0274 |
27-Hydroxycholesterol
27-羟基胆固醇,5,25R-胆甾烯-3BETA,26-二醇,25(R)-27-hydroxy Cholesterol |
Estrogen/progestogen Receptor; Liver X Receptor | Endocrinology/Hormones; Metabolism |
27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) 是一种有效的、选择性的雌激素受体调节剂和肝X 受体激动剂。 | |||
T34295 |
Resiniferatoxin
RTX,[3H]resiniferatoxin,树脂毒素 |
IL Receptor | Immunology/Inflammation |
Resiniferatoxin ([3H]resiniferatoxin) 抑制 Th1 细胞因子的产生,有助于防御 T.spiralis 感染,并可用于免疫反应调节剂的研究。 | |||
TN6457 |
N-trans-caffeoyltyramine
Trans-N-Caffeoyltyramine,N-(E)-Caffeoyl-lambda-tyramine,N-cis-Caffeoyltyramine,Typheramide |
Immunology/Inflammation related | Immunology/Inflammation |
N-trans-caffeoyltyramine (Trans-N-Caffeoyltyramine) 是炎症反应的调节剂,可用于慢性炎症性疾病治疗的研究。 | |||
T2845 |
Imperatorin
Ammidin,8-Isoamylenoxypsoralen,欧前胡素,8-Isopentenyloxypsoralene,Marmelosin,Pentosalen |
TRP/TRPV Channel; AChR; AChE; NOD | Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; NF-κB |
Imperatorin (8-Isopentenyloxypsoralene) 是NO synthesis 和BChE 的抑制剂,IC50分别为 9.2 μmol 和 31.4 μmol。它也是TRPV1的微弱激动剂,EC50为 12.6±3.2 μM。 | |||
T4720 |
6-Hydroxypyridin-2(1H)-one hydrochloride
2,6-二羟基吡啶盐酸盐,2,6-Dihydroxypyridine hydrochloride |
Others; Endogenous Metabolite | Metabolism; Others |
6-Hydroxypyridin-2(1H)-one hydrochloride (2,6-Dihydroxypyridine hydrochloride) 是内源性代谢产物的一种。 | |||
T3318 |
Wogonoside
汉黄芩苷,Glychionide B,Wogonin 7-O-glucuronide,Oroxindin |
GABA Receptor; Autophagy | Autophagy; Membrane transporter/Ion channel; Neuroscience |
Wogonoside (Wogonin 7-O-glucuronide) 是从黄芩中分离得到的一种黄酮类天然产物,具有抗炎作用。它是 GABAA 受体苯二氮卓位点的正变构调节剂,可通过调节 MAPK-mTOR 通路诱导乳腺癌细胞的自噬。 | |||
TN3174 |
6-Methoxyflavanone
NSC50184 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
6-Methoxyflavanone(6-MeOF)是人重组GABA A受体GABA反应的正变构调节剂,具有抗焦虑活性和抗炎活性,可用于减轻顺铂诱导的神经性疼痛。 | |||
TN1879 |
Lucideric acid A
Lucidenic acid A,赤芝酸A |
MMP; p38 MAPK; JNK | MAPK; Proteases/Proteasome |
Lucideric acid A (Lucidenic acid A) 是分离自灵芝的天然产物,可抑制 PMA 诱导的MMP-9活性,具有抵抗肝癌细胞侵袭的作用。 | |||
T14046 |
Anandamide
花生四烯酸乙醇胺,(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide |
Cannabinoid Receptor; Endogenous Metabolite | GPCR/G Protein; Metabolism |
Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide) 是一种免疫调节剂,通过大麻素受体 CB1 和 CB2 起作用,还通过中枢神经系统中的其他靶点起作用,如 GPR18/GPR55。 | |||
TN2359 |
Iristectorigenin B
Iristectrigenin B |
Liver X Receptor | Metabolism |
Iristectorigenin B (Iristectrigenin B) 是一种有效的肝脏 X 受体 (LXR) 调节剂,是从 Belamcanda chinensis 中分离的小分子化合物。Iristectrigenin B 可促进巨噬细胞 RAW 1.1 细胞中 ABCA264 和 ABCG7 的表达。 | |||
TN1325 |
(2S)-6-Prenylnaringenin
(2S)-6-异戊烯基柚皮素,6-异戊二烯基柚皮素,6-Prenylnaringenin,6-PN |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
(2S)-6-Prenylnaringenin (6-Prenylnaringenin) 是强效植物雌激素 8-prenylnaringenin 的异构体,是前脑中最有效的化合物,在 α+β 结合位点上起GABAA 正变构调节剂的作用。 | |||
TN1202 |
(-)-α-Pinene
左旋-α-蒎烯,左旋-alpha-蒎烯,(1S)-(-)-Alpha-Pinene |
Virus Protease; GABA Receptor; Endogenous Metabolite; Antibacterial | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience |
(-)-α-Pinene ((1S)-(-)-Alpha-Pinene) 是一种单萜类化合物,通过延长 GABAergic 突触传递、作为 GABAA-BZD 受体的部分调节剂并直接与 GABAA 受体的 BZD 结合位点结合来增强 NREMS 的数量而不影响 NREMS 的强度。 | |||
TN1420 |
Bacopaside I
|
Others | Others |
Bacopaside I 是一种皂苷,分离自 Bacopa monniera 中,具有抗氧化活性和清除自由基的功能,有抗抑郁作用。 | |||
T2946 |
Tanshinone IIA sulfonate sodium
丹参酮IIA磺酸盐,丹参酮IIA-磺酸钠,Tanshinone IIA sulfonate,Sodium Tanshinone IIA sulfonate,Tanshinone IIA sodium sulfonate,sodium |
CaMK; P450; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) 是从丹参中提取的丹参酮IIA 的水溶性衍生物,是SOCE 抑制剂,用于心血管疾病的研究。 | |||
T1549 |
Raloxifene hydrochloride
LY156758 hydrochloride,盐酸雷洛昔芬,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl |
Estrogen Receptor/ERR; Others; MAO; Estrogen/progestogen Receptor; Autophagy | Autophagy; Endocrinology/Hormones; Metabolism; Neuroscience; Others |
Raloxifene hydrochloride (LY156758 hydrochloride) 是一种选择性且可口服的雌激素受体调节剂,用于预防绝经后妇女的骨质疏松症。它对骨骼和胆固醇代谢具有雌激素激动作用,但对乳腺和子宫组织具有完全的雌激素拮抗作用。 | |||
T4S0181 |
Hinokiflavone
日本扁柏黄酮,扁柏双黄酮 |
MMP; BCL; E1/E2/E3 Enzyme | Apoptosis; Proteases/Proteasome; Ubiquitination |
Hinokiflavone 是pre-mRNA 剪接活性的新型调节剂,通过抑制剪接体装配来阻止pre-mRNA 底物的剪接,特别是阻止 B complex 的形成。它是SUMO protease 蛋白酶抑制剂,能够抑制前哨蛋白特异性蛋白酶 1 的活性。 | |||
T15248 |
Estetrol
Donesta |
Estrogen Receptor/ERR; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Estetrol(Donesta) 是可口服且具有选择性核雌激素受体 (estrogen receptor) 调节剂,是一种在怀孕期间由人类胎儿肝脏合成的天然雌激素。Estetrol 对子宫内膜或中枢神经系统有作用,但对乳房有拮抗作用。Estetrol 在低浓度时可能有助于降低血栓形成。Estetrol 可用于缓解更年期症状。 | |||
T3923 |
Calycosin
Cyclosin,3'-Hydroxyformononetin,异黄酮,毛异黄酮 |
Apoptosis; Tyrosinase | Apoptosis; Proteases/Proteasome |
Calycosin (Cyclosin) 是一抗氧化和抗炎症活性天然产物。 | |||
T4S21320 |
ISOGINKGETIN
异银杏素,4',4'''-Dimethylamentoflavone,异银杏双黄酮 |
MMP; Others | Others; Proteases/Proteasome |
ISOGINKGETIN (4',4'''-Dimethylamentoflavone) 是一种MMP9抑制剂,也是一种Pre-mRNA Splicing 抑制剂。 | |||
T3753 |
Sinapinic Acid
Sinapic acid,芥子酸,Synapoic acid |
Apoptosis; RAAS; Reactive Oxygen Species; HDAC | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB |
Sinapinic Acid (Synapoic acid) 是从 Hydnophytum formicarumJack. 根中分离到的酚类,是HDAC 抑制剂,对ACE-I 的活性也有抑制作用。它有抗肿瘤活性,诱导肿瘤细胞凋亡,具有抗氧化、抗糖尿病的作用。 | |||
T24744 |
Rubone
|
||
Rubone is the tumor suppressor miRNA-34a modulator that acts by inhibiting the growth of hepatocellular carcinoma. | |||
TMA1004 | Lucidenic acid F | p38 MAPK; JNK | MAPK |
Lucidenic acid F as a modulator of JNK and p38, it shows potent inhibitory effects on EBV-EA induction. | |||
TN2116 |
Pteropodine
|
BCL; Calcium Channel; 5-HT Receptor | Apoptosis; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Pteropodine acts as a positive modulator of muscarinic M(1) and 5-HT(2) receptors. Pteropodine shows antigenotoxic, antioxidant and lymphocyte induction effects, it also shows strong apoptotic effect on acute leukaemic lymphoblasts. | |||
T12787 |
Ryanodine
|
Others | Others |
Ryanodine, a diterpenoid poison derived from Ryania speciosa, acts as a modulator of the ryanodine receptor, which is permeable to cells. Depending on its concentration, ryanodine can either stimulate or inhibit Ca2+ release mediated by these receptors. | |||
T14831 |
Bryostatin 1
|
HIV Protease; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome |
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein (Kis: 8.07 nM and 0.45 nM). | |||
TN1099 |
Dihydroevocarpine
|
MAO; P-gp; Antifection | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience |
Dihydroevocarpine shows potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. Dihydroevocarpine is a moderate modulator of p-glycoprotein (p-gp) activity; it shows more potent inhibitory effects against MAO-B compared to MAO-A. | |||
TN1842 |
Kushenol I
|
GABA Receptor; Antifection | Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience |
Kushenol I is a GABAA receptor modulator, it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).Kushenol I is shown to be active against the plant pathogenic fungus Cladosporium cucumerinum. | |||
TN4016 |
Ethyl 2,4,6-trihydroxybenzoate
|
Liver X Receptor | Metabolism |
Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing lipid accumulation in HepG2 cells. It suppresses cellular cholesterol accumulation in a dose-dependent manner and induces the transcriptional activation of LXR-α/-β-responsive genes. | |||
TMA0424 |
Martynoside
|
ROS | Immunology/Inflammation |
Martynoside is a natural selective estrogen receptor modulator, which has antioxidative, anti-muscle fatigue, anticancer and antimetastatic activities. Martynoside has the potential of antagonizing sports anaemia, the mechanism of this effect might be rel | |||
TN1790 |
Isopteropodine
Uncarine E |
5-HT Receptor; Antibacterial; AChR | GPCR/G Protein; Microbiology/Virology; Neuroscience |
Isopteropodine (Uncarine E) 是从 Hamelia patens micropropagated 分离得到的一种异育亨宾型辛吲哚生物碱.具有抗菌活性,可刺激机体免疫系统。Isopteropodine 是 M1 型毒蕈碱乙酰胆碱 (muscarinic M1) 受体及 5-HT2 受体的正向调节剂,是PXR激活剂,可诱导大鼠子宫肌层收缩。 | |||
TN4635 | Neoechinulin A | NADPH-oxidase; Beta Amyloid; ASK; IκB/IKK; p38 MAPK; TNF; NOS; NF-κB; COX; Prostaglandin Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; Neuroscience; NF-κB |
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regu |