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76

抑制剂 & 化合物

7

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6

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178

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Cat. No. Product Name
L3600 细胞因子抑制剂库

604 compounds
604 个与细胞因子紧密相关的化合物集合,是高通量、高内涵筛选的良好载体;
L7200 钙通道分子库

140 compounds
140 种钙通道相关化合物的独特集合,可用于高通量筛选和高内涵筛选;
L6750 活血化瘀中药单体库

580 compounds
580种来源于常见活血化瘀中药的单体化合物,是药物开发、药理研究等领域的有效工具。
L4700 免疫/炎症分子化合物库

4720 compounds
4720 种具有抗炎症活性的化合物的特有集合,可用于高通量筛选和高内涵筛选;
L9600 多肽分子库

791 compounds
791 种多肽类分子,可用于多肽药物开发及信号转导通路和作用机制研究;
L9840 抗阿尔茨海默症化合物库

986 compounds
986 种阿尔茨海默症相关的化合物集合,可用于高通量和高内涵筛选;

化合物库

细胞因子抑制剂库
Cat.No: L3600
Compounds: 604
钙通道分子库
Cat.No: L7200
Compounds: 140
活血化瘀中药单体库
Cat.No: L6750
Compounds: 580
免疫/炎症分子化合物库
Cat.No: L4700
Compounds: 4720
多肽分子库
Cat.No: L9600
Compounds: 791
抗阿尔茨海默症化合物库
Cat.No: L9840
Compounds: 986
Cat. No. Product Name Target Signaling Pathways
TP1422 Interleukin (IL)-6 Receptor

Others Others
Interleukin (IL)-6 Receptor 是一种肽,来源于白细胞介素6受体。
T3571 SU5201

NSC 247030

Others; Interleukin Immunology/Inflammation; Others
SU5201 (NSC 247030) 对白细胞介素 2 (IL-2) 的产生具有抑制作用。
T76724 Nemolizumab

CIM331

Interleukin Immunology/Inflammation
Nemolizumab (CIM331) 是一种人源化的抗人白细胞介素-31 受体 a 单克隆抗体,对白细胞介素-31 (IL-31) 与其受体的结合和随后的信号转导有抑制作用。Nemolizumab 可用于研究特应性皮炎伴瘙痒。
T7572 RN-1734

2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺

TRP/TRPV Channel Membrane transporter/Ion channel
RN-1734是TRPV4通道的选择性拮抗剂,拮抗 4αPDD 介导的 TRPV4 活化,作用于 hTRPV4, mTRPV4, 和 rTRPV4的IC50分别为 2.3 μM、5.9 μM、3.2 μM。RN-1734能显著降低白细胞介素 1β和肿瘤坏死因子 α 的产生,而不改变 olig2- 阳性细胞的数量。
T4140 IRAK4-IN-1

IRAK Immunology/Inflammation; NF-κB
IRAK4-IN-1 是白细胞介素-1 受体相关激酶 4 抑制剂(IC50:7 nM)。
T5110 IRAK inhibitor 6

IRAK Immunology/Inflammation; NF-κB
IRAK inhibitor 6 是白细胞介素-1受体相关激酶-4的抑制剂(IC50:160 nM)。
T5641 RP-54745

Interleukin Immunology/Inflammation
RP-54745 是一种能抑制噬细胞刺激和的白介素-1 的产生的化合物,对风湿病的治疗具有潜在的研究价值。
T67924 ABzOH

ABzOH 是一种苯甲酸衍生物,结构类似于阿司匹林等非甾体抗炎药,具有抗炎、抗肿瘤和抗增殖作用。ABzOH 不仅可以抑制肿瘤坏死因子- α (TNF-a)、白细胞介素-1β (IL-1β)和白细胞介素-6 (IL-6)等促炎细胞因子的表达还对乳腺癌、肺癌和胰腺癌具有抑制作用。
T6465 Dexamethasone Sodium Phosphate

Dexadreson,地塞米松磷酸钠,Dexagro,Dalalone

IL Receptor; COX Immunology/Inflammation; Neuroscience
Dexamethasone Sodium Phosphate (Dexadreson) 是一种白细胞介素受体调节剂,具有抗炎和免疫抑制作用。它属于类固醇合成药物的强效糖皮质激素类。
T16695 Pyrintegrin

Integrin Cytoskeletal Signaling
Pyrintegrin 是一种 β1 整合素激动剂,也是 2,4-二取代的嘧啶,可促进胚胎干细胞存活。它可用作足细胞保护剂,能增强细胞-细胞外基质 (ECM) 粘附介导的整联蛋白信号传导,具有强大的成脂作用。
T10497 Benralizumab

BIW-8405,MEDI-563

Apoptosis; IL Receptor; Interleukin Apoptosis; Immunology/Inflammation
Benralizumab (MEDI-563) 是一种靶向白介素 5 受体 α (IL-5Rα) 单克隆抗体,通过增强抗体依赖性细胞介导的细胞毒性促使嗜酸性粒细胞快速进行反应。Benralizumab 可用于严重的嗜酸性哮喘,可用于预防慢性阻塞性肺病加重。
T70489 Enerisant HCl

P450; Histamine Receptor GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
Enerisant HCl是一种新型强效选择性组胺H3受体拮抗剂,是P-gp的底物,由细胞色素P450(CYP)和转运蛋白介导。
T68455 AP23846

AP-23846

Src Angiogenesis; Tyrosine Kinase/Adaptors
AP23846 是一种新型高效的 Src 家族激酶抑制剂,可降低人实体瘤细胞系中血管内皮生长因子和白细胞介素-8 的表达,并消除下游血管生成过程。
T35569 CTA 056

Apoptosis Apoptosis
CTA 056 是白细胞介素-2 诱导的 T 细胞激酶(ITK)抑制剂,抑制小鼠 MOLT-4 异种移植肿瘤的生长,诱导 Jurkat 细胞凋亡,可用于研究自身免疫性疾病和T细胞恶性肿瘤。
T76722 Sarilumab

REGN-88,SAR-153191

IL Receptor Immunology/Inflammation
Sarilumab(SAR-153191) 是一种有效的白细胞介素-6 IL-6 受体拮抗剂,是人源免疫球蛋白 G1 单克隆抗体。 Sarilumab 抑制由 IL-6 介导的信号传导,可减少炎症。Sarilumab 可用于预防和治疗类风湿关节炎。
T7368 IRAK inhibitor 2

IRAK-IN-2

IRAK Immunology/Inflammation; NF-κB
IRAK inhibitor 2 (IRAK-IN-2) 是一种有效的白细胞介素1受体相关激酶4(IRAK-4)抑制剂,具有潜在的抗癌和抗癌活性,可用于研究炎症相关性疾病。
T22062 CCG-100602

Rho; Ras Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
CCG-100602 是心肌蛋白相关转录因子 A/血清反应因子信号转导的特异性抑制剂。它抑制 PC-3 前列腺癌细胞中 RhoA/C 介导的、SRF 驱动的荧光素酶表达,IC50为 9.8 µM。
T73698 Basiliximab

CHI 621

Interleukin Immunology/Inflammation
Basiliximab (CHI 621) 是一种嵌合鼠/人 IgG1 单克隆抗白细胞介素 2 受体 (interleukin-2 receptor) 重组抗体。Basiliximab 具有良好的免疫抑制活性,可用于研究肾移植。
T21527 HBX 41108

HBX-41108,7-氯-9-氧代-9H-茚并[1,2-B]吡嗪-2,3-二甲腈

DUB; p53 Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
HBX 41108 (HBX-41108) 是一种泛素特异性蛋白酶 7 的非竞争性抑制剂,IC50为 424 nM。它诱导 p53 依赖的凋亡,抑制 USP7 介导的 p53 去泛素化以稳定 p53 并抑制癌细胞生长。
T9911 Tocilizumab

Interleukin Immunology/Inflammation
Tocilizumab 是抗人白细胞介素-6 受体 (IL-6R) 的中和抗体,能够阻碍 IL-6 与 IL-6R 的结合,进而抑制经典和反式信号。它可用于研究类风湿性关节炎,对重症 COVID-19 冠状病毒病方面的研究具有显著效果。
T12343 Benzquinamide

BZQ,P2647,Benzoquinamide

Adrenergic Receptor GPCR/G Protein; Neuroscience
Benzquinamide (P2647) 是一种具有抗癌活性的止吐剂, 抑制p糖蛋白介导的药物外排,增强多重耐药细胞中抗癌药物的细胞毒性。Benzquinamide 对 α2A, α2B, 以及α2C 肾上腺素能受体(α2-AR)的 Ki值分别为 1,365, 691 和 545 nM。
T76775 Fezakinumab

ILV 094

Interleukin Immunology/Inflammation
Fezakinumab 是一种有效的白细胞介素 22 (IL-22) 单克隆抗体。Fezakinumab 可用于研究银屑病、类风湿性关节炎和特应性皮炎等免疫系统疾病和炎症相关疾病。
T36534 SDZ 224-015

SDZ 224015

IL Receptor; Caspase Apoptosis; Immunology/Inflammation; Proteases/Proteasome
SDZ 224-015 是白细胞介素-1β(IL-1β)转化酶和 Caspase-1 的口服活性抑制剂。SDZ 224-015 具有抗 COVID-19 和抗炎活性,可减少角叉菜胶诱导的大鼠爪子水肿。
T60739L Y13g dihydrochloride

Y13g 2HCl(T60739 Free base)

IL Receptor; AChE Immunology/Inflammation; Neuroscience
Y13g dihydrochloride 是白细胞介素 6 (IL-6) 和乙酰胆碱酯酶 (AChE)的有效抑制剂(这两个靶点阿尔茨海默症 (AD) 进展的有关)。Y13g dihydrochloride 逆转 STZ 诱导的记忆缺陷,并表现出与正常动物相似的组织病理学。
T14367 AZ1495

IRAK; CDK; Haspin Kinase Cell Cycle/Checkpoint; Immunology/Inflammation; NF-κB
AZ1495 是一种口服有活性的白介素-1受体相关激酶 4(IRAK4)抑制剂,能够作用于 IRAK4 (IC50:5 nM)和 IRAK1 (IC50:23 nM)。可用于研究突变型 MYD88L265P 弥漫性 B 细胞淋巴瘤 (DLBCL) 。
T76884 Spesolimab

BI 655130

IL Receptor Immunology/Inflammation
Spesolimab (BI 655130) 是一种抗白细胞介素-36 受体抗体。IL-36 在免疫系统中具有重要作用,与先天性 Th1/Th17 和中性粒细胞途径相关的生物标志物的减少有关。Spesolimab 可用于研究全身性脓疱型银屑病、掌跖脓疱病 (PPP) 和特应性皮炎。。
T13666 Dupilumab

REGN-668,SAR-231893

IL Receptor Immunology/Inflammation
Dupilumab (REGN-668) 是一种用于AD 的全身免疫调节剂。Dupilumab 是一种针对白细胞介素-4受体α亚基的完全人类单克隆抗体,可抑制IL-4和IL-13下游信号传导,具有改善特应性皮炎的作用。
T41142 EM 163

IL Receptor; p38 MAPK; MyD88 Immunology/Inflammation; MAPK
EM 163是一种 TIR-TIR 相互作用抑制剂,它是MyD88蛋白的TIR(Toll/白细胞介素-1受体)结构域拟态。EM 163针对IL-1受体中的TIR 结构域,阻断与MyD88的相互作用。EM 163抑制葡萄球菌肠毒素B(SEB)引起的体内炎症细胞因子的产生。EM 163能保护小鼠免受SEB 冲击引起的死亡。在体外的大鼠海马神经元中,EM 163阻断p38的激活和IL-1β对化学诱导的长期电位(LTP)引发的蛋白质合成的抑制作用。
T38105 Ixekizumab

LY2439821

IL Receptor; Interleukin Immunology/Inflammation
Ixekizumab (LY2439821) 是一种人源化 IgG4 单克隆抗体,可选择性结合和中和白细胞介素 IL-17A ,Kd 值<3 pM。Ixekizumab 科阻断 IL-17A 与 IL-17RA 的结合,但不与其他 IL-17 家族成员结合。Ixekizumab 用于治疗中重度斑块型银屑病、银屑病关节炎和牛皮癣。
T14075 A-802715

IL Receptor Immunology/Inflammation
A-802715 是一种新型甲基黄嘌呤衍生物,可降低促炎物质的内源性形成和血液水平,并增加白细胞介素10受体和肿瘤坏死因子受体等抗炎物质的形成和血液水平。
T77353 MyD88-IN-1

IL Receptor; NF-κB; TLR; MyD88 Immunology/Inflammation; NF-κB
MyD88-IN-1 是一种有效的 MyD88 抑制剂。MyD88-IN-1 具有抗炎活性,可抑制 Toll 样受体 (TLR) 和白细胞介素-1 (IL-1) 受体家族成员下游炎症信号通路 ,包括NF-κB 通路。MyD88-IN-1 可用于研究癌症和治疗炎症。
T34973 Tyrphostin 8

4-Hydroxybenzylidenemalononitrile

EGFR; GTPase Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Tyrphostin 8(4-Hydroxybenzylidenemalononitrile) 是一种有效的 GTP 酶抑制剂,对 EGFR 激酶有抑制作用, IC50 值为 560 μM。Tyrphostin 8 可抑制蛋白丝氨酸/苏氨酸钙调磷酸酶 (IC50=21 μM),增强 Caco-2 细胞中转铁蛋白受体介导的转吞作用,并增加口服胰岛素 - 转铁蛋白的降血糖作用。
T71857 GTP-14564

FLT; Tyrosine Kinases Angiogenesis; Tyrosine Kinase/Adaptors
GTP-14564是一种新型酪氨酸激酶抑制剂,对 wt-FLT3和ITD-FLT3也具有抑制作用。GTP-14564 在 3μ m 处抑制表达 ITD-FLT3 的白细胞介素-3 非依赖性 Ba/F1 的生长,而需要高 30 倍的 GTP-14564 浓度来抑制表达野生型 FLT3 的 Ba/F3 的 FLT3 配体依赖性生长 (wt-FLT3)。
TP2158 TRV-120027 TFA

TRV-120027 TFA (1234510-46-3 free base)

RAAS; Arrestin Endocrinology/Hormones; GPCR/G Protein
TRV-120027 TFA 是一种血管紧张素 II 介导的血管收缩抑制剂,可增加心肌细胞的收缩力。它是一种偏向 β-arrestin-1 的 AT1R 激动剂,可与 ß-arrestins 结合,同时阻断 G 蛋白信号传导。 它通过阳离子通道亚家族 C3 (TRPC3) 偶联诱导急性儿茶酚胺分泌,并促进在质膜上形成由 AT1R-β-arrestin-1-TRPC3-PLCγ 组成的大分子复合物。
T12781 RV01

Others Others
RV01 是一种新型的白藜芦醇喹啉取代类似物,可抑制 DNA 损伤,降低乙醇诱导的乙醛脱氢酶 (ALDH2) 的 mRNA 表达,具有清除羟自由基的活性。RV01 降低 iNOS 的表达,具有抗神经炎症作用。RV01降低肿瘤坏死因子-a (TNF-a)和白细胞介素-6 (IL-6) mRNA 水平和分泌,抑制lps 诱导的ROS 生成和烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶活化,降低toll 样受体4 (TLR4)的蛋白表达,抑制lps 诱导的丝裂原活化蛋白激酶(MAPK)和核转录因子-кB (NF-кB)信号通路的激活。
T76256 Erepdekinra

Erepdekinra 是一种白细胞介素-17A (IL-17A) 受体拮抗剂。
T11670 IRAK inhibitor 3

IRAK Immunology/Inflammation; NF-κB
IRAK inhibitor 3 是白细胞介素-1受体相关激酶调节剂。
T73697 Denileukin diftitox

Denileukin diftitox (DAB 389IL-2) 是一种融合蛋白毒素,将白喉毒素 (DT) 与白细胞介素 2 (IL-2) 结合,专门针对表达高亲和力IL-2受体 (IL-2R)、CD25 的细胞。它通过与IL-2R阳性细胞结合并利用白喉毒素片段的内化作用来抑制蛋白质合成,从而达到耗尽目标细胞的效果。
T76379 Myelopeptide-2

Myelopeptide-2 分离于猪骨髓细胞培养上清,能够恢复 HL-60 白血病细胞或麻疹病毒条件抑制下人 T 淋巴细胞的丝裂原反应活性、白细胞介素-2 (IL-2) 合成水平和白细胞介素-2受体 (IL-2R) 表达水平。Myelopeptide-2 参与免疫稳态调节,在抗肿瘤和抗病毒研究中具有广阔的应用前景。
T76771 Pivekimab

Pivekimab为针对白介素3(IL-3)及CD123的人源IgG1型单克隆抗体。适用于母细胞浆细胞样树突状细胞肿瘤(BPDCN)研究。
T78079 NF546 hydrate

P2Y Receptor GPCR/G Protein; Neuroscience
NF546 (hydrate)为选择性非核苷酸P2Y11激动剂,具有pEC50值为6.27。该化合物可促进人单核细胞源性树突状细胞释放白细胞介素-8。
T76797 Anti-Human IL-17A

Anti-HumanIL-17A 是一种全人抗白细胞介素 17A 单克隆抗体。Anti-HumanIL-17A 可用于银屑病发病机制研究。
T83745 RYTVELA TFA

H-Arg-Tyr-Thr-Val-Glu-Leu-Ala-OH

RYTVELA是一种基于多肽拮抗剂的衍生物,针对白细胞介素-1受体1(IL-1R1),包含全部的L-氨基酸。
T76753 Olokizumab

Olokizumab (CDP 6038) 是一种人源化单克隆抗体,靶向白细胞介素-6 (IL-6),适用于类风湿关节炎 (RA) 的研究。
T76953 Xeligekimab

Xeligekimab (GR 1501)为一种针对人白细胞介素17A (IL-17A) 的人源化单克隆抗体,可抑制促炎级联反应。
T76675 Clazakizumab

Clazakizumab是一种具有高亲和力和特异性的单克隆抗体,针对IL-6(白细胞介素-6)细胞因子。它可能对抑制COVID-19中因SARS-CoV-2引起的细胞因子反应有帮助。此外,Clazakizumab也被用于研究银屑病关节炎(PsA)和肾抗体介导的排斥反应。
T80854 Vopikitug

Vopikitug为IgG1-kappa型人源单克隆抗体,针对IL-2RA(白细胞介素2受体α亚基,亦称IL-2RA、TAC、p55、CD25)具有特异性,并展现出抗肿瘤活性。
T19883 Ac-YVAD-CHO

L 709049,L-709049,L709049

L 709049是一种生物活性化合物,它是白细胞介素-1β转化酶( Caspase-1)的选择性抑制剂。 Caspase 抑制剂可干扰细胞凋亡的启动,具有多种临床应用前景。
T80513 YVAD-CHO

YVAD-CHO为白细胞介素-1β转换酶(ICE,caspase 1)的抑制剂,能够在一定程度上减缓面神经损伤小鼠运动神经元死亡速率。
T82887 Bifikafusp alfa

L19-IL2

Bifikafusp alfa (L19-IL2) 是一种由人类L19抗体与细胞因子白介素2 (IL2) 结合而成的免疫融合蛋白,特异性针对纤维连接蛋白的EDB区域,并表现出抗癌活性。

化合物

Interleukin (IL)-6 Receptor
Cat.No: TP1422
Synonym:
Target: Others
SU5201
Cat.No: T3571
Synonym: NSC 247030
Target: Others, Interleukin
Nemolizumab
Cat.No: T76724
Synonym: CIM331
Target: Interleukin
RN-1734
Cat.No: T7572
Synonym: 2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺
Target: TRP/TRPV Channel
IRAK4-IN-1
Cat.No: T4140
Synonym:
Target: IRAK
IRAK inhibitor 6
Cat.No: T5110
Synonym:
Target: IRAK
RP-54745
Cat.No: T5641
Synonym:
Target: Interleukin
ABzOH
Cat.No: T67924
Synonym:
Target:
Dexamethasone Sodium Phosphate
Cat.No: T6465
Synonym: Dexadreson,地塞米松磷酸钠,Dexagro,Dalalone
Target: IL Receptor, COX
Pyrintegrin
Cat.No: T16695
Synonym:
Target: Integrin
Benralizumab
Cat.No: T10497
Synonym: BIW-8405,MEDI-563
Target: Apoptosis, IL Receptor, Interleukin
Enerisant HCl
Cat.No: T70489
Synonym:
Target: P450, Histamine Receptor
AP23846
Cat.No: T68455
Synonym: AP-23846
Target: Src
CTA 056
Cat.No: T35569
Synonym:
Target: Apoptosis
Sarilumab
Cat.No: T76722
Synonym: REGN-88,SAR-153191
Target: IL Receptor
IRAK inhibitor 2
Cat.No: T7368
Synonym: IRAK-IN-2
Target: IRAK
CCG-100602
Cat.No: T22062
Synonym:
Target: Rho, Ras
Basiliximab
Cat.No: T73698
Synonym: CHI 621
Target: Interleukin
HBX 41108
Cat.No: T21527
Synonym: HBX-41108,7-氯-9-氧代-9H-茚并[1,2-B]吡嗪-2,3-二甲腈
Target: DUB, p53
Tocilizumab
Cat.No: T9911
Synonym:
Target: Interleukin
Benzquinamide
Cat.No: T12343
Synonym: BZQ,P2647,Benzoquinamide
Target: Adrenergic Receptor
Fezakinumab
Cat.No: T76775
Synonym: ILV 094
Target: Interleukin
SDZ 224-015
Cat.No: T36534
Synonym: SDZ 224015
Target: IL Receptor, Caspase
Y13g dihydrochloride
Cat.No: T60739L
Synonym: Y13g 2HCl(T60739 Free base)
Target: IL Receptor, AChE
AZ1495
Cat.No: T14367
Synonym:
Target: IRAK, CDK, Haspin Kinase
Spesolimab
Cat.No: T76884
Synonym: BI 655130
Target: IL Receptor
Dupilumab
Cat.No: T13666
Synonym: REGN-668,SAR-231893
Target: IL Receptor
EM 163
Cat.No: T41142
Synonym:
Target: IL Receptor, p38 MAPK, MyD88
Ixekizumab
Cat.No: T38105
Synonym: LY2439821
Target: IL Receptor, Interleukin
A-802715
Cat.No: T14075
Synonym:
Target: IL Receptor
MyD88-IN-1
Cat.No: T77353
Synonym:
Target: IL Receptor, NF-κB, TLR, MyD88
Tyrphostin 8
Cat.No: T34973
Synonym: 4-Hydroxybenzylidenemalononitrile
Target: EGFR, GTPase
GTP-14564
Cat.No: T71857
Synonym:
Target: FLT, Tyrosine Kinases
TRV-120027 TFA
Cat.No: TP2158
Synonym: TRV-120027 TFA (1234510-46-3 free base)
Target: RAAS, Arrestin
RV01
Cat.No: T12781
Synonym:
Target: Others
Erepdekinra
Cat.No: T76256
Synonym:
Target:
IRAK inhibitor 3
Cat.No: T11670
Synonym:
Target: IRAK
Denileukin diftitox
Cat.No: T73697
Synonym:
Target:
Myelopeptide-2
Cat.No: T76379
Synonym:
Target:
Pivekimab
Cat.No: T76771
Synonym:
Target:
NF546 hydrate
Cat.No: T78079
Synonym:
Target: P2Y Receptor
Anti-Human IL-17A
Cat.No: T76797
Synonym:
Target:
RYTVELA TFA
Cat.No: T83745
Synonym: H-Arg-Tyr-Thr-Val-Glu-Leu-Ala-OH
Target:
Olokizumab
Cat.No: T76753
Synonym:
Target:
Xeligekimab
Cat.No: T76953
Synonym:
Target:
Clazakizumab
Cat.No: T76675
Synonym:
Target:
Vopikitug
Cat.No: T80854
Synonym:
Target:
Ac-YVAD-CHO
Cat.No: T19883
Synonym: L 709049,L-709049,L709049
Target:
YVAD-CHO
Cat.No: T80513
Synonym:
Target:
Bifikafusp alfa
Cat.No: T82887
Synonym: L19-IL2
Target:
Cat. No. Product Name Target Signaling Pathways
T7210 Guanosine 5'-diphosphate

GDP,鸟苷-5ˊ-二磷酸

Endogenous Metabolite Metabolism
Guanosine 5'-diphosphate (GDP) 是核苷二磷酸,是潜在的铁动员剂,能够阻断铁调素-铁转运蛋白相互作用并调节白细胞介素-6 (IL-6)/stat-3 途径。
TN1702 Glycycoumarin

甘草香豆素

P450; JNK; AMPK; Autophagy Autophagy; Chromatin/Epigenetic; MAPK; Metabolism; PI3K/Akt/mTOR signaling
Glycycoumarin 是甘草中的一种香豆素,能直接靶向 T-LAK 细胞源蛋白激酶发挥抗肝癌活性 。它通过激活自噬,抑制内质网应激介导的 JNK 和 GSK-3 介导的线粒体途径,来抑制肝细胞脂性凋亡。它是一种雌激素激动剂,对 CYP1A2 和 CYP2B6 有中度抑制作用。
T6S0077 Byakangelicol

COX Immunology/Inflammation; Neuroscience
Byakangelicol 是一种分离自白芷的白三醇,能够抑制环加氧酶-2的表达及活性,从而减少白细胞介素-1β诱导的 A549 细胞中前列腺素 E2 的释放。它可用于研究气道炎症。
TN5171 Tricetin

Apoptosis; Others; Nrf2 Apoptosis; Immunology/Inflammation; Others
Tricetin 是一种从石榴中分离出的类黄酮。Tricetin 是 Keap1-Nrf2 蛋白相互作用(PPI)的强效竞争性抑制剂,通过激活 Nrf2/HO-1 信号通路和阻止线粒体依赖性细胞凋亡通路,保护帕金森病患免受 6-OHDA 诱导的神经毒性的影响。Tricetin 通过 Akt/GSK-1β途径抑制鼻咽癌的迁移和指示性蛋白酶早老素-1(PS-1)表达。Tricetin 抑制由Egr-1介导的氧化LDL 诱导的内皮炎症,保护大鼠软骨细胞免受IL-1β诱导的炎症和细胞凋亡。
T38373 2-heptyl-3-hydroxy-4(1H)-Quinolone

2-heptyl-3-hydroxy-4(1H)-Quinolone,PQS,Pseudomonas Quinolone Signal

Others Others
2-heptyl-3-hydroxy-4(1H)-Quinolone (Pseudomonas Quinolone Signal) 是一种铜绿假单胞菌为应对细胞密度增加而产生的一种法定人数感应信号分子。 它增加了铜绿假单胞菌中lasB 基因的表达,增加代谢物焦蓝蛋白和凝集素PA-IL 的分泌,以及增加铜绿假单胞菌种群的生物膜生产。当使用浓度为40 μM 时,它还会降低铜绿假单胞菌生长介质中的铁含量,并在硫酸铁溶液中充当一种铁螯合剂。
T79941 Antimycin A2c

Apoptosis Apoptosis
Anticanceragent 141(compound AE)是一种针对HPV感染宫颈癌具有抑制作用的抗霉素生物碱。该化合物能够抑制宫颈癌HeLa细胞的增殖并导致细胞周期在S期停滞。Anticanceragent 141破坏线粒体功能,诱导caspase依赖性细胞凋亡,并激活ROS介导的泛素依赖性蛋白酶体系统,进而引起E6/E7癌蛋白的降解。
TN5153 Torilin

MMP; ERK; IκB/IKK; p38 MAPK; NF-κB; Tyrosinase; Reductase; DNA/RNA Synthesis; JNK Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Endocrinology/Hormones; MAPK; Metabolism; NF-κB; Proteases/Proteasome
Torilin 是一种睾酮5α还原酶抑制剂,它(IC50=31.7+/-4.23μM)对5α还原酶的抑制作用强于α-亚麻酸(IC50=160.3+/-24.62μM),但弱于非那雄胺(IC50=0.38+/-0.06μM)。Torilin 具有免疫调节、肝脏保护和抗炎特性,它通过限制 TAK1介导的 MAP 激酶和 NF-βB 活化来抑制炎症,它可以减轻关节炎的严重程度,改变 dLN 或关节中的白细胞活化,并恢复血清和脾细胞细胞因子失衡。托利林抑制α-黑素细胞刺激激素激活的 B16黑色素瘤细胞中的黑色素生成,IC(50)值为25μM。Torilin 对枯草芽孢杆菌 ATCC 6633孢子和营养细胞表现出优异的抗菌活性。Torilin 在体内和体外都具有强大的抗血管生成活性,它可能通过抑制肿瘤侵袭来抑制肿瘤发生,逆转癌细胞的多药耐药性,它可以增强阿霉素、长春碱、紫杉醇和秋水仙碱对多药耐药 KB-V1和 MCF7/ADR 细胞的细胞毒性。

天然产物

Guanosine 5'-diphosphate
Cat.No: T7210
Synonym: GDP,鸟苷-5ˊ-二磷酸
Target: Endogenous Metabolite
Glycycoumarin
Cat.No: TN1702
Synonym: 甘草香豆素
Target: P450, JNK, AMPK, Autophagy
Byakangelicol
Cat.No: T6S0077
Synonym:
Target: COX
Tricetin
Cat.No: TN5171
Synonym:
Target: Apoptosis, Others, Nrf2
2-heptyl-3-hydroxy-4(1H)-Quinolone
Cat.No: T38373
Synonym: 2-heptyl-3-hydroxy-4(1H)-Quinolone,PQS,Pseudomonas Quinolone Signal
Target: Others
Antimycin A2c
Cat.No: T79941
Synonym:
Target: Apoptosis
Torilin
Cat.No: TN5153
Synonym:
Target: MMP, ERK, IκB/IKK, p38 MAPK, NF-κB, Tyrosinase, Reductase, DNA/RNA Synthesis, JNK
Cat. No. Product Name Species Expression System
TMPY-03298 IL-6 Protein, Rat, Recombinant

白细胞介素,interleukin 6,白介素

Rat E. coli
Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affini...
TMPY-02789 IL-33 Protein, Canine, Recombinant

白介素,interleukin 33,白细胞介素

Canine E. coli
Interleukin 33 (IL-33), also known as DVS27 or NF-HEV (Nuclear Factor from High Endothelial Venules), is a pro-inflammatory protein and a chromatin-associated cytokine of the IL-1 family with high sequence and structural similarity to IL-1 and IL-18. IL-33 protein is expressed highly and rather selectively by high endothelial venule endothelial cells (HEVECs) in human tonsils, Peyer's patches, and lymph nodes. IL-33 protein has transcriptional regulatory properties, and the researches suggested ...
TMPY-05523 IL-31 Protein, Cynomolgus, Recombinant (His)

白介素,白细胞介素,interleukin 31

Cynomolgus HEK293
IL-31 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 cells.
TMPY-01940 IL-31 Protein, Mouse, Recombinant (His)

白细胞介素,interleukin 31,1700013B14Rik,白介素

Mouse HEK293
IL-31 Protein, Mouse, Recombinant (His) is expressed in HEK293 cells.
TMPY-02457 IL-2 Protein, Rat, Recombinant

interleukin 2,白细胞介素,白介素

Rat E. coli
Interleukin-2, also known as a T-cell growth factor, TCGF, Aldesleukin, and IL2, is a secreted protein that belongs to the IL-2 family. Interleukin-2 / IL-2 was the first interleukin molecule to be discovered. Interleukin-2 / IL-2 molecule was first purified to homogeneity by immunoaffinity chromatography by Kendall Smith and his team at Dartmouth Medical School. Interleukin-2 / IL-2 was also the first cytokine shown to mediate its effects via a specific IL-2 receptor, and it was also the first ...
TMPY-00982 IL-13 Protein, Cynomolgus, Recombinant

白介素,interleukin 13,白细胞介素

Cynomolgus HEK293
Interleukin 13 (IL-13) is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. IL-13 protein is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL-13 Rα1 and IL-13 Rα2). As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses, and disease...
TMPY-03327 IL-6 Protein, Rhesus, Recombinant

白介素,interleukin 6,白细胞介素

Rhesus E. coli
Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affini...
TMPY-01928 IL-18 Protein, Rhesus, Recombinant (His)

白细胞介素,interleukin 18,白介素

Rhesus E. coli
Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its bi...
TMPY-05449 IL-33 Protein, Cynomolgus, Recombinant

白细胞介素,interleukin 33,白介素

Cynomolgus E. coli
Interleukin 33 (IL-33), also known as DVS27 or NF-HEV (Nuclear Factor from High Endothelial Venules), is a pro-inflammatory protein and a chromatin-associated cytokine of the IL-1 family with high sequence and structural similarity to IL-1 and IL-18. IL-33 protein is expressed highly and rather selectively by high endothelial venule endothelial cells (HEVECs) in human tonsils, Peyer's patches, and lymph nodes. IL-33 protein has transcriptional regulatory properties, and the researches suggested ...
TMPY-03238 IL-6 Protein, Mouse, Recombinant

白介素,Il-6,白细胞介素,interleukin 6

Mouse E. coli
Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affini...
TMPY-04212 IL-16 Protein, Mouse, Recombinant (His)

白介素,interleukin 16,mKIAA4048,白细胞介素

Mouse E. coli
IL-16 Protein, Mouse, Recombinant (His) is expressed in E. coli with His tag. The predicted molecular weight is 14.5 kDa. Accession number: O54824-1
TMPY-02554 IL-5 Protein, Mouse, Recombinant (His)

白细胞介素,interleukin 5,白介素,Il-5

Mouse Baculovirus-Insect Cells
Interleukin 5 (IL-5) is a member of the interleukin family with a length of 115 amino acids. Interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes) and has been found in a wide variety of body cells. Interleukin 5 or IL-5 is produced by T helper-2 cells and mast cells. It helps to stimulate B cell growth and increase immunoglobulin secretion and is considered a key mediator in eosinophil activation. Int...
TMPY-03273 IL-18 Protein, Mouse, Recombinant

interleukin 18,白细胞介素,白介素,Il-18,Igif

Mouse E. coli
Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its bi...
TMPJ-00575 IL-13 Protein, Human, Recombinant (His)

Interleukin-13,IL-13,白介素,白细胞介素

Human Human Cells
Interleukin-13 is also known as IL-13. It is a protein that in humans is encoded by the IL13 gene. Interleukin-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells.It is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokin...
TMPY-03526 IL-23 Protein, Mouse, Recombinant (His)

IL-23,白细胞介素,p19,白介素

Mouse HEK293
IL-23 Protein, Mouse, Recombinant (His) is expressed in HEK293 cells.
TMPY-05064 IL-10 Protein, Mouse, Recombinant

白介素,白细胞介素,CSIF,interleukin 10,Il-10

Mouse E. coli
IL-10 is an anti-inflammatory cytokine that belongs to the IL-10 family. It is produced by a variety of cell lines, including T-cells, macrophages, mast cells, and other cell types, while it is produced primarily by monocytes and to a lesser extent by lymphocytes. IL-10 is mainly expressed in monocytes and Type 2 T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and also in a certain subset of activated T cells and B cells. IL-10 has pleiotropic effects in immunoregulation an...
TMPY-02445 IL-1 beta/IL-1F2 Protein, Rhesus, Recombinant

interleukin 1, beta,IL-1 β,白介素,interleukin 1, β,白细胞介素

Rhesus E. coli
Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishme...
TMPY-02227 IL-1 beta/IL-1F2 Protein, Rat, Recombinant (mature form)

白细胞介素,interleukin 1, beta,白介素,interleukin 1, β,IL-1...

Rat E. coli
Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishme...
TMPY-02788 IL-2 Protein, Mouse, Recombinant

Il-2,白细胞介素,interleukin 2,白介素

Mouse E. coli
Interleukin-2, also known as a T-cell growth factor, TCGF, Aldesleukin, and IL2, is a secreted protein that belongs to the IL-2 family. Interleukin-2 / IL-2 was the first interleukin molecule to be discovered. Interleukin-2 / IL-2 molecule was first purified to homogeneity by immunoaffinity chromatography by Kendall Smith and his team at Dartmouth Medical School. Interleukin-2 / IL-2 was also the first cytokine shown to mediate its effects via a specific IL-2 receptor, and it was also the first ...
TMPY-03123 IL-13 Protein, Mouse, Recombinant

白细胞介素,Il-13,白介素,interleukin 13

Mouse HEK293
Interleukin 13 (IL-13) is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. IL-13 protein is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL-13 Rα1 and IL-13 Rα2). As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses, and disease...
TMPJ-00059 IL-7 Protein, Human, Recombinant (His)

Interleukin-7,IL7,白细胞介素,IL-7,白介素

Human Human Cells
Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-spe...
TMPY-04107 IL-31 Protein, Human, Recombinant (His)

interleukin 31,白介素,白细胞介素,IL-31

Human HEK293
IL-31 Protein, Human, Recombinant (His) is expressed in HEK293 cells.
TMPY-04632 IL-15 Protein, Human, Recombinant

白细胞介素,IL-15,白介素,interleukin 15

Human E. coli
The protein encoded by the IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietic receptor subunits and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as ...
TMPY-04178 IL-11 Protein, Mouse, Recombinant

IL-11,interleukin 11,白细胞介素,白介素

Mouse E. coli
IL11 is a multifunctional cytokine first isolated in 199 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 is also known under the names adipogenesis inhibitory factor (AGIF) and oprelvekin. IL11 can improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute-phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell prolifer...
TMPY-03942 IL-36 gamma Protein, Mouse, Recombinant (His)

interleukin 36, γ,IL36 γ,IL36g,Il1f9,interleukin 36, gamma,<...

Mouse E. coli
IL-36 gamma Protein, Mouse, Recombinant (His) is expressed in E. coli.
TMPY-03915 IL-5 Protein, Human, Recombinant

TRF,白介素,EDF,interleukin 5,IL-5,白细胞介素

Human E. coli
Interleukin 5 (IL-5) is a member of the interleukin family with a length of 115 amino acids. Interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes) and has been found in a wide variety of body cells. Interleukin 5 or IL-5 is produced by T helper-2 cells and mast cells. It helps to stimulate B cell growth and increase immunoglobulin secretion and is considered a key mediator in eosinophil activation. Int...
TMPY-02558 IL-4 Protein, Mouse, Recombinant

白介素,白细胞介素,BSF-1,Il-4,interleukin 4

Mouse E. coli
IL-4 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13.4 kDa and the accession number is P07750.
TMPY-03488 IL-11 Protein, Human, Recombinant

白细胞介素,interleukin 11,IL-11,白介素,AGIF

Human E. coli
IL11 is a multifunctional cytokine first isolated in 199 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 is also known under the names adipogenesis inhibitory factor (AGIF) and oprelvekin. IL11 can improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute-phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell prolifer...
TMPY-03383 IL-7 Protein, Human, Recombinant

IL-7,interleukin 7,Interleukin-7,白介素,白细胞介素

Human E. coli
IL7, also known as interleukin 7, is a hematopoietic growth factor that belongs to the IL-7/IL-9 family. It is secreted by stromal cells in the bone marrow and thymus. IL7 stimulates the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. IL7 and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. It is found to be a cofactor for V(D)J rearrangement of the T cell recep...
TMPY-02241 IL-16 Protein, Human, Recombinant (His)

LCF,prIL-16,白介素,NIL16,白细胞介素,interleukin 16,PRIL16

Human E. coli
IL-16 Protein, Human, Recombinant (His) is expressed in E. coli with His tag. The predicted molecular weight is 15.3 kDa. Accession number: AAC12732.1
TMPY-01963 IL-21 Protein, Human, Recombinant

CVID11,IL-21,白介素,白细胞介素,Za11,interleukin 21

Human E. coli
IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the i...
TMPY-02134 IL-1 beta/IL-1F2 Protein, Mouse, Recombinant

Il-1b,IL-1beta,白细胞介素,interleukin 1, β,interleukin 1...

Mouse E. coli
Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishme...
TMPY-05576 IL-5 Protein, Human, Recombinant (His)

白细胞介素,白介素,EDF,TRF,interleukin 5,IL-5

Human HEK293
Interleukin 5 (IL-5) is a member of the interleukin family with a length of 115 amino acids. Interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes) and has been found in a wide variety of body cells. Interleukin 5 or IL-5 is produced by T helper-2 cells and mast cells. It helps to stimulate B cell growth and increase immunoglobulin secretion and is considered a key mediator in eosinophil activation. Int...
TMPY-04845 IL-3 Protein, Mouse, Recombinant

Il-3,白介素,PSF,HCGF,BPA,白细胞介素,MCGF,Csfmu,interleukin ...

Mouse HEK293
IL3 (interleukin 3), also known as IL-3, is a potent growth-promoting cytokine that belongs to the IL-3 family. IL3/IL-3 also belongs to the group of interleukins. Interleukins are produced by a wide variety of body cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well ...
TMPY-00297 IL-3 Protein, Human, Recombinant(aa 20-152)

interleukin 3,白介素,白细胞介素,Interleukin-3,IL-3,MCGF,MUL...

Human E. coli
IL3 (interleukin 3), also known as IL-3, is a potent growth-promoting cytokine that belongs to the IL-3 family. IL3/IL-3 also belongs to the group of interleukins. Interleukins are produced by a wide variety of body cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well ...
TMPY-01993 IL-13 Protein, Human, Recombinant

IL-13,P600,interleukin 13,ALRH,白介素,白细胞介素

Human CHO
Interleukin 13 (IL-13) is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. IL-13 protein is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL-13 Rα1 and IL-13 Rα2). As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses, and disease...
TMPY-01870 IL-9 Protein, Human, Recombinant (His)

P40,interleukin 9,HP40,白细胞介素,IL-9,白介素

Human Baculovirus-Insect Cells
Interleukin 9, also known as IL-9, is a cytokine (cell signaling molecule) belonging to the group of interleukins. IL-9 is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL-9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. Genetic studies on a mouse model of asth...
TMPY-00840 IL-13 Protein, Human, Recombinant (hFc)

IL-13,白介素,白细胞介素,ALRH,interleukin 13,P600

Human HEK293
Interleukin 13 (IL-13) is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. IL-13 protein is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL-13 Rα1 and IL-13 Rα2). As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses, and disease...
TMPY-02959 IL-20 Protein, Human, Recombinant

ZCYTO10,interleukin-20,IL10D,白细胞介素,interleukin 20,白...

Human E. coli
IL20/Interleukin-20 belongs to the IL-10 family. It is a cytokine structurally related to interleukin 10. IL20/Interleukin-20 can be detected in skin, trachea, and other tissues. It is produced by activated keratinocytes and monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other epithelial cells. It has been shown that interleukin-20 transduces its signal through signal transducer and activator of transcription 3 (STAT3) in...
TMPY-00136 IL-29 Protein, Human, Recombinant

interferon, λ1,IL-29,IL29,interferon, lambda 1,IFNL1,白介素,

Human HEK293
Interleukin-29 (IL-29), also known as cytokine Zcyto21, Interferon lambda-1, IFN-lambda-1, and IFNL1, is a secreted protein that belongs to the IL-28 / IL-29 family. IL-29 is a cytokine with immunomodulatory activity. IL-29 is highly similar in amino acid sequence to the IL-28. IL-28 and IL-29 are induced by a viral infection and showed antiviral activity. IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10Rbeta) and an orphan c...
TMPY-01845 IL-10 Protein, Human, Recombinant (His)

GVHDS,TGIF,CSIF,interleukin 10,IL-10,Interleukin-10,IL10A,

Human HEK293
IL-10 is an anti-inflammatory cytokine that belongs to the IL-10 family. It is produced by a variety of cell lines, including T-cells, macrophages, mast cells, and other cell types, while it is produced primarily by monocytes and to a lesser extent by lymphocytes. IL-10 is mainly expressed in monocytes and Type 2 T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and also in a certain subset of activated T cells and B cells. IL-10 has pleiotropic effects in immunoregulation an...
TMPY-03142 IL-27 Protein, Human, Recombinant (His)

IL27p28,IL-27,白介素,IL27A,interleukin 27,p28,白细胞介素,IL...

Human CHO
IL-27 protein is a member of the IL-6 superfamily, which is expressed on monocytes, endothelial cells, and dendritic cells. IL-27 protein is also referred to as the IL-12 p35-related protein, p28, is one subunit of a heterodimeric cytokine complex, and associates with another subunit EBI3 (EBV-induced gene 3), and IL-12 p40-related protein (IL-27B). IL-27 protein is an early product of activated antigen-presenting cells and drives the rapid clonal expansion of naive CD4(+) T cells and plays a ro...
TMPY-03153 IL-27 Protein, Mouse, Recombinant (His)

p28,Il30,IL-27,白介素,interleukin 27,IL-27p28,白细胞介素

Mouse HEK293
IL-27 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.5 kDa and the accession number is O35228&Q8K3I6.
TMPY-00861 IL-33 Protein, Human, Recombinant

IL1F11,C9orf26,NFEHEV,NF-HEV,DVS27,白介素,interleukin 33,白细...

Human E. coli
Interleukin 33 (IL-33), also known as DVS27 or NF-HEV (Nuclear Factor from High Endothelial Venules), is a pro-inflammatory protein and a chromatin-associated cytokine of the IL-1 family with high sequence and structural similarity to IL-1 and IL-18. IL-33 protein is expressed highly and rather selectively by high endothelial venule endothelial cells (HEVECs) in human tonsils, Peyer's patches, and lymph nodes. IL-33 protein has transcriptional regulatory properties, and the researches suggested ...
TMPY-05648 IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated

IL23,IL-23,白细胞介素,白介素,P19,IL23P19,SGRF,IL-23A

Human HEK293
IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 with His and AVI tag. The predicted molecular weight is 57.6 kDa. Accession number: NP_002178.2&NP_057668.1
TMPY-03547 IL-10 Protein, Human, Recombinant

Interleukin-10,TGIF,CSIF,IL10A,IL-10,白介素,白细胞介素,GVHD...

Human E. coli
IL-10 is an anti-inflammatory cytokine that belongs to the IL-10 family. It is produced by a variety of cell lines, including T-cells, macrophages, mast cells, and other cell types, while it is produced primarily by monocytes and to a lesser extent by lymphocytes. IL-10 is mainly expressed in monocytes and Type 2 T helper cells (TH2), mast cells, CD4+CD25+Foxp3+ regulatory T cells, and also in a certain subset of activated T cells and B cells. IL-10 has pleiotropic effects in immunoregulation an...
TMPY-02900 IL-17A Protein, Mouse, Recombinant

IL-17A,Ctla8,Ctla-8,interleukin 17A,Il17,白介素,白细胞介素,...

Mouse E. coli
IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocyt...
TMPY-00863 IL-6 Protein, Human, Recombinant

BSF2,白细胞介素,HSF,IL-6,IFNB2,interleukin 6,HGF,Interle...

Human E. coli
Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affini...
TMPJ-00889 IL-13 Protein, Mouse, Recombinant (aa 22-131, His)

T-Cell Activation Protein P600,IL-13,白细胞介素,Interleu...

Mouse Human Cells
Mouse interleukin 13 (mIL-13) is a pleiotropic cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation and immunoglobin production. It contains a four helical bundle with two internal disulfide bonds. Mouse IL13 shares 58% sequence identity with human protein and exhibits cross-species activity. IL13 signals via receptor IL13R (type2, IL4R) and activates STAT-6. IL13 initially binds IL-13Rα1 with low affinity and triggers association of IL4Rα, generating a high affinity hete...
TMPJ-01463 IL-2 Protein, Human, Recombinant (E. coli)

Aldesleukin,IL-2,IL2,T-Cell Growth Factor,TCGF,白细胞介素

Human E. coli
IL-2 Protein, Human, Recombinant (E. coli) is expressed in E. coli expression system. The accession number is P60568.
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重组蛋白

IL-6 Protein, Rat, Recombinant
Cat.No: TMPY-03298
Species: Rat
Expression System: E. coli
IL-33 Protein, Canine, Recombinant
Cat.No: TMPY-02789
Species: Canine
Expression System: E. coli
IL-31 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPY-05523
Species: Cynomolgus
Expression System: HEK293
IL-31 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01940
Species: Mouse
Expression System: HEK293
IL-2 Protein, Rat, Recombinant
Cat.No: TMPY-02457
Species: Rat
Expression System: E. coli
IL-13 Protein, Cynomolgus, Recombinant
Cat.No: TMPY-00982
Species: Cynomolgus
Expression System: HEK293
IL-6 Protein, Rhesus, Recombinant
Cat.No: TMPY-03327
Species: Rhesus
Expression System: E. coli
IL-18 Protein, Rhesus, Recombinant (His)
Cat.No: TMPY-01928
Species: Rhesus
Expression System: E. coli
IL-33 Protein, Cynomolgus, Recombinant
Cat.No: TMPY-05449
Species: Cynomolgus
Expression System: E. coli
IL-6 Protein, Mouse, Recombinant
Cat.No: TMPY-03238
Species: Mouse
Expression System: E. coli
IL-16 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-04212
Species: Mouse
Expression System: E. coli
IL-5 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-02554
Species: Mouse
Expression System: Baculovirus-Insect Cells
IL-18 Protein, Mouse, Recombinant
Cat.No: TMPY-03273
Species: Mouse
Expression System: E. coli
IL-13 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00575
Species: Human
Expression System: Human Cells
IL-23 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-03526
Species: Mouse
Expression System: HEK293
IL-10 Protein, Mouse, Recombinant
Cat.No: TMPY-05064
Species: Mouse
Expression System: E. coli
IL-1 beta/IL-1F2 Protein, Rhesus, Recombinant
Cat.No: TMPY-02445
Species: Rhesus
Expression System: E. coli
IL-1 beta/IL-1F2 Protein, Rat, Recombinant (mature form)
Cat.No: TMPY-02227
Species: Rat
Expression System: E. coli
IL-2 Protein, Mouse, Recombinant
Cat.No: TMPY-02788
Species: Mouse
Expression System: E. coli
IL-13 Protein, Mouse, Recombinant
Cat.No: TMPY-03123
Species: Mouse
Expression System: HEK293
IL-7 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00059
Species: Human
Expression System: Human Cells
IL-31 Protein, Human, Recombinant (His)
Cat.No: TMPY-04107
Species: Human
Expression System: HEK293
IL-15 Protein, Human, Recombinant
Cat.No: TMPY-04632
Species: Human
Expression System: E. coli
IL-11 Protein, Mouse, Recombinant
Cat.No: TMPY-04178
Species: Mouse
Expression System: E. coli
IL-36 gamma Protein, Mouse, Recombinant (His)
Cat.No: TMPY-03942
Species: Mouse
Expression System: E. coli
IL-5 Protein, Human, Recombinant
Cat.No: TMPY-03915
Species: Human
Expression System: E. coli
IL-4 Protein, Mouse, Recombinant
Cat.No: TMPY-02558
Species: Mouse
Expression System: E. coli
IL-11 Protein, Human, Recombinant
Cat.No: TMPY-03488
Species: Human
Expression System: E. coli
IL-7 Protein, Human, Recombinant
Cat.No: TMPY-03383
Species: Human
Expression System: E. coli
IL-16 Protein, Human, Recombinant (His)
Cat.No: TMPY-02241
Species: Human
Expression System: E. coli
IL-21 Protein, Human, Recombinant
Cat.No: TMPY-01963
Species: Human
Expression System: E. coli
IL-1 beta/IL-1F2 Protein, Mouse, Recombinant
Cat.No: TMPY-02134
Species: Mouse
Expression System: E. coli
IL-5 Protein, Human, Recombinant (His)
Cat.No: TMPY-05576
Species: Human
Expression System: HEK293
IL-3 Protein, Mouse, Recombinant
Cat.No: TMPY-04845
Species: Mouse
Expression System: HEK293
IL-3 Protein, Human, Recombinant(aa 20-152)
Cat.No: TMPY-00297
Species: Human
Expression System: E. coli
IL-13 Protein, Human, Recombinant
Cat.No: TMPY-01993
Species: Human
Expression System: CHO
IL-9 Protein, Human, Recombinant (His)
Cat.No: TMPY-01870
Species: Human
Expression System: Baculovirus-Insect Cells
IL-13 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00840
Species: Human
Expression System: HEK293
IL-20 Protein, Human, Recombinant
Cat.No: TMPY-02959
Species: Human
Expression System: E. coli
IL-29 Protein, Human, Recombinant
Cat.No: TMPY-00136
Species: Human
Expression System: HEK293
IL-10 Protein, Human, Recombinant (His)
Cat.No: TMPY-01845
Species: Human
Expression System: HEK293
IL-27 Protein, Human, Recombinant (His)
Cat.No: TMPY-03142
Species: Human
Expression System: CHO
IL-27 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-03153
Species: Mouse
Expression System: HEK293
IL-33 Protein, Human, Recombinant
Cat.No: TMPY-00861
Species: Human
Expression System: E. coli
IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-05648
Species: Human
Expression System: HEK293
IL-10 Protein, Human, Recombinant
Cat.No: TMPY-03547
Species: Human
Expression System: E. coli
IL-17A Protein, Mouse, Recombinant
Cat.No: TMPY-02900
Species: Mouse
Expression System: E. coli
IL-6 Protein, Human, Recombinant
Cat.No: TMPY-00863
Species: Human
Expression System: E. coli
IL-13 Protein, Mouse, Recombinant (aa 22-131, His)
Cat.No: TMPJ-00889
Species: Mouse
Expression System: Human Cells
IL-2 Protein, Human, Recombinant (E. coli)
Cat.No: TMPJ-01463
Species: Human
Expression System: E. coli
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