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Search Results for " inhibitory activities "

62

抑制剂 & 化合物

129

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9231	Mbx2329	Antiviral	Immunology/Inflammation
	MBX2329 是一种流感病毒抑制剂，能特异性地抑制血凝素介导的病毒进入，HIV/HA(H5) 的 IC90值为8.6 μM。它能够有效地抑制多种甲型流感病毒。
T4197	HZ-1157 HZ1157,DHFR-inhibitor	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	HZ-1157 (DHFR-inhibitor) 是一种丙型肝炎病毒抑制剂，对 HCV NS3/4A 蛋白酶具有抑制活性。
T72022	11β-HSD1 inibitor 19
	11β-HSD1 inibitor 19 对 hHSD1 和 mHSD1 显示抑制活性，IC50 为 16 nM 和 10 nM。
T16169	N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride	Others; Proteasome; COX	Immunology/Inflammation; Neuroscience; Others; Proteases/Proteasome; Ubiquitination
	N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride (N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride) 是胰蛋白酶样蛋白酶的抑制剂。 N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride 对 IFN-γ 活性具有抑制作用。
T9907	Nivolumab	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	Nivolumab 是PD-1抗体类抑制剂，可用于研究晚期（转移性）非小细胞肺癌。
T21593	AAL-993	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	AAL-993 是口服有效的VEGFR 选择性抑制剂，抑制 VEGFR1、VEGFR2 和 VEGFR3 的IC50分别为 130 nM、23 nM 和 18 nM，对其他酪氨酸激酶的抑制作用较弱。AAL-993 具有抗血管生成和抗肿瘤的活性。
T0094	Budesonide Entocort,Pulmicort,布地奈德,Rhinocort	Glucocorticoid Receptor	Endocrinology/Hormones
	Budesonide (Pulmicort) 是吸入型糖皮质类固醇，是一种口服具有活性的糖皮质激素受体激动剂。它能够减小肺部肿瘤的体积，逆转 DNA 低度甲基化，调节基因的 mRNA 表达。它是能够用于哮喘的抗炎药。
T7218	Endomorphin 2 内吗啡肽 2	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Endomorphin 2 是一种高亲和力和选择性的 μ-阿片受体激动剂，对 kappa3 结合位点具有合理的亲和力，Ki 为 20 到 30 nM 之间。
T32535	Ladostigil TV-3326,Ladostigil,TV 3326,TV3326,Ladostigil free base	Antioxidant; MAO; AChE	Metabolism; Neuroscience; oxidation-reduction
	Ladostigil (Ladostigil free base) 是一种具有口服活性的胆碱酯酶和脑选择性单胺氧化酶(MAO)双重抑制剂，对 MAO-B 和 AChE 具有抑制作用，IC50值分别为37.1和31.8μM。Ladostigil 具有抗炎、抗氧化和神经保护活性，可用于研究抑郁症和阿尔茨海默病。
T35900	JAK2-IN-7 JAK2-IN-7	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK2-IN-7 是一种选择性 JAK2抑制剂，对 JAK2，SET-2 和 Ba/F3V617F 细胞的IC50为 3、11.7 和 41 nM。 JAK2-IN-7 的选择性是 JAK1, JAK3，FLT3 的 14 倍以上。JAK2-IN-7 刺激细胞周期停滞在 G0/G1 期，并诱导肿瘤细胞凋亡 (apoptosis)，具有抗肿瘤活性。
T32191	Irdabisant CEP-26401,CEP 26401,CEP26401	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Irdabisant (CEP-26401) 是选择性、口服活性和血脑屏障渗透性的组胺 H3 受体 (histamine H3 receptor, H3R) 拮抗剂/逆激动剂。Irdabisant 显示人 H3R 和大鼠 H3R 的 Ki 分别为 2.0 nM 和 7.2 nM。Irdabisant 抑制 hERG 电流的活性相对较低 (IC50= 13.8 μM)。在大鼠社会认知模型中，Irdabisant 具有认知增强和唤醒作用。Irdabisant 可用于研究精神分裂症或认知障碍。
T6529	Halobetasol propionate 卤贝他索丙酸酯,Halobetasol Propionate,Ulobetasol propionate,BMY-30056,卤倍他索丙酸酯,CGP-14458	Phospholipase	Metabolism
	Halobetasol propionate (BMY-30056) 是一种在皮肤外使用的合成类固醇，具有抗炎，止痒和收缩血管的活性。
T28533	RH01617 RH-01617,RH 01617
	RH01617 possesses potent inhibitory activities against Kv1.5.
T10016	Hydrocarbon chain derivative 1 6,6'-Oxybis[2,2-dimethyl-1-hexanol]	Others	Others
	Hydrocarbon chain derivative 1 has inhibitory activities against lipid synthesis.
T32371	Kebuzone Chepirol,RN 0308507,Chebutan,Chetazolidin,Chetil
	Kebuzone is a non-steroidal anti-inflammatory drug, known to have analgesic, antipyretic, and platelet inhibitory activities.
T24431	Matlystatin A
	Matlystatin A is an inhibitor of aminopeptidase. It shows multiple inhibitory activities against both aminopeptidase N and matrix metalloproteinases.
T71377	Oberadilol
	Oberadilol is a pyridazinone derivative with vasodilatory and beta-adrenergic blocking activities and type III phosphodiesterase inhibitory action
T71376	Tzc 5665
	Tzc 5665 is a pyridazinone derivative with vasodilatory and beta-adrenergic blocking activities and type III phosphodiesterase inhibitory action.
T36484	BCL6-IN-4 BCL6-IN-4
	BCL6-IN-4, a potent inhibitor of B-cell lymphoma 6 (BCL6), exhibits anti-tumor activities with an inhibitory concentration 50 (IC50) value of 97 nM[1].
T39966	SGLT1/2-IN-2 SGLT1/2-IN-2
	SGLT1/2-IN-2 is a chemical compound with robust dual inhibitory properties, exhibiting potent activities against SGLT1 (IC50 = 96 nM) and SGLT2 (IC50 = 1.3 nM).
T40903	ACG416B
	ACG416B (compound 18) exhibits formidable inhibitory effects on choline kinase (ChoK), with an IC 50 measurement of 0.4 μM. Notably, ACG416B demonstrates superior inhibitory activities against HT-29 human colon cancer cells, resulting in pronounced antiproliferative effects.
T40447	T-705RMP
	T-705RMP, the phosphorylated metabolite derived from T-705, demonstrates a limited inhibitory impact on the host cells' IMP dehydrogenase (IMPDH) activities, with an IC 50 value of 601 μM.
T69872	TM-9
	TM-9 is a novel multi-function inhibitor for the treatment of Alzheimer's disease (AD). TM-9 exhibits potent and balanced inhibitory activities against ChE and MAO-B.
T61242	Tubulin inhibitor 12
	Tubulin inhibitor 12 (Hit 9) is a recently developed compound with potent inhibitory effects on tubulin (IC50 = 25.3 μM). This compound exhibits noteworthy anti-tumor and anti-proliferative activities, making it a promising candidate for the treatment of cancer [1].
T11396	GGTI-2418	Transferase	Metabolism
	GGTI-2418 inhibits GGTase I and FTase activities with IC50s of 9.5 nM and 53 μM, respectively. GGTI-2418 also increases p27(Kip1) and induces significant regression of breast tumors. GGTI-2418 is a highly potent, competitive, and selective geranylgeranyltransferase I (GGTase I) inhibitor.
T11282L	FGTI-2734 mesylate (1247018-19-4 free base) FGTI-2734 mesylate	Others	Others
	FGTI-2734 mesylate, a RAS C-terminal mimetic compound with dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitory activities (IC50s of 250 nM and 520 nM for FT and GGT, respectively), mitigates KRAS resistance by preventing its membrane localization, effectively impeding mutant KRAS patient-derived pancreatic tumors.
T74243	Tyrosinase/elastase-IN-1
	Tyrosinase/elastase-IN-1，一种来源于悬钩子叶的三萜类化合物，具有抑制酪氨酸酶和弹性蛋白酶活性的功能。
T35438	(5E)-7-Oxozeaenol
	(5E)-7-Oxozeaenol is a resorcylic acid lactone that has been found in the fungus MSX 63935 and has enzyme inhibitory and anticancer activities.1,2 It inhibits TGF-β-activated kinase 1 (TAK-1; IC50 = 1.3 μM).1 (5E)-7-Oxozeaenol inhibits proliferation of MCF-7, H460, SF-268, HT-29, and MDA-MB-435 human cancer cells with IC50 values of 4.9, 1.2, 5.6, 4.4, and 5.5 μM, respectively.2 \|1. Fakhouri, L., El-Elimat, T., Hurst, D.P., et al. Isolation, semisynthesis, covalent docking and transforming growt...
T80363	Maximin 41
	Maximin 41是一种具有针对S. aureus抗菌活性（MIC: 75 μg/mL）的抗菌肽，同时对人红细胞展现溶血活性。
T61415	FLT3/ITD-IN-1
	FLT3/ITD-IN-1 (Compound 1) is a highly potent inhibitor of FLT3 internal tandem duplications (FLT3-ITD). It exhibits remarkable inhibitory effects against FLT3 and FLT3-ITD, with impressive IC50 values of 38.2 nM and 144.1 nM, respectively. Moreover, FLT3/ITD-IN-1 shows exceptional antiproliferative activities against several acute myeloid leukemia cell lines [1].
T61272	EGFR/HER2-IN-7
	EGFR/HER2-IN-7 is a highly selective and potent anticancer compound specifically designed to target MCF-7 breast cancer cells. It functions as a dual inhibitor, targeting both EGFR/HER2 kinases and DHFR (dihydrofolate reductase). Its inhibitory activities are measured with IC50 values of 0.18 μM for EGFR, 0.146 μM for HER2, and 0.907 μM for DHFR [1].
T35975	6,9-Dichloro-1,2,3,4-tetrahydroacridine
	6,9-Dichloro-1,2,3,4-tetrahydroacridine is a synthetic intermediate in the synthesis of tacrine-based acetylcholinesterase (AChE) inhibitors.1It is also an intermediate in the synthesis of multifunctional tacrine hybrids that possess radical scavenging, amyloid-β aggregation inhibitory, and/or β-secretase 1 (BACE1) inhibitory activities in addition to their activity as AChE inhibitors.2,3 1.Recanatini, M., Cavalli, A., Belluti, F., et al.SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylchol...
T61509	Neuraminidase-IN-8
	Neuraminidase-IN-8 (Compound 6d) 是一种有效的神经氨酸酶 (neuraminidase) 抑制剂，其IC50值为 0.027 μM。Neuraminidase-IN-8 具有抗流感活性。
T16565	Ppc-1	Others	Others
	Ppc-1 is a chemical compound known for its inhibitory effects on the Gram-negative periodontopathogen Porphyromonas gingivalis. It acts as a mitochondrial uncoupler, enhancing mitochondrial oxygen consumption without affecting ATP production. Additionally, Ppc-1 serves as a cell-permeate inhibitor of interleukin-2 (IL-2). This compound exhibits various beneficial activities, including anti-obesity, antibacterial, and anti-inflammatory properties.
T79538	PDE4-IN-13
	PDE4-IN-13 is a phosphodiesterase 4 inhibitor with an IC50 value of 1.56 μM, exhibiting anti-inflammatory and antioxidative properties. It is utilized in the study of chronic obstructive pulmonary disease (COPD).
T60921	PF-07038124
	PF-07038124是 PDE4 的抑制剂。PF-07038124 对 PDE4B2 的 IC50值为0.5 nM。PF-07038124 对IFNγ、IL-4 和 IL-13具有抑制活性，IC50值分别为 1.06、4.1 和125 nM。
T38800	MMPI-1154
	MMPI-1154 is a highly promising imidazole-carboxylic acid (ICA) MMP-2 inhibitor (IC 50 = 6.6 μM) with excellent cardio-cytoprotective properties. It is specifically designed for the study of acute myocardial infarction. Additionally, MMPI-1154 exhibits significant inhibitory effects on MMP-13, MMP-1, and MMP-9 activities with IC 50 values of 1.8 μM, 10 μM, and 13 μM, respectively.
T35798	Massarigenin C
	Massarigenin C is a fungal metabolite that has been found inM. flavoroseaand has enzyme inhibitory activities.1,2Massarigenin C inhibits neuraminidasein vitro(IC50= 4.15 μM).2It is also an inhibitor of yeast α-glucosidase (IC50= 1.25 mM).1It reduces the postprandial peak in blood glucose levels in an oral sucrose tolerance test in normo- and hyperglycemic mice when administered at doses of 3.2, 10, and 31.6 mg/kg.
T80365	Maximin H39
	Maximin H39为一种抗菌肽，对C. albicans、S. aureus、B. subtilis展示抗菌活性（MIC: 9.4, 9.4, 18.8 μg/mL），且对人类及兔子红细胞具溶血活性。
T61476	Thioridazine
	Thioridazine is a chemical compound characterized by its potent anti-psychotic and anti-anxiety activities. As an antagonist of the dopamine receptor D2 family proteins, it exhibits a strong inhibitory effect on the PI3K-Akt-mTOR signaling pathways, resulting in anti-angiogenic effects. It also demonstrates significant antiproliferative and apoptosis induction effects in a diverse range of cancer cells, specifically targeting cancer stem cells (CSCs) [1] [2] [3] [4].
T81777	MMP-9-IN-8
	MMP-9-IN-8（Compound 3）是MMP-9抑制剂，10 μM浓度下抑制活性为42.16%，50 μM时达58.28%。该化合物展现抗癌活性，能诱导MCF-7细胞凋亡，IC50为23.42 μM。
T63696	HDAC-IN-9
	HDAC-IN-9 是有效的、选择性的 tubulin 和 HDAC 双重抑制剂。HDAC-IN-9 对 A549 细胞的侵袭和迁移表现出抑制作用。HDAC-IN-9 在体外和体内均表现出有效的抗肿瘤和抗血管生成活性。
T80367	Maximin 78
	Maximin 78为一种具有广谱抗菌性能的肽类化合物。该化合物展现出针对C. albicans、S. aureus、B. subtilis的显著抗菌活性，最小抑菌浓度（MIC）分别为37.5、4.7、37.5 μg/mL。此外，Maximin 78对人类和兔子红细胞显示出溶血活性。
T71860	Ambuic acid
	Ambuic acid is a cyclohexanone that has phytopathogenic antifungal, quorum sensing inhibitory, and antibacterial activities. Ambuic acid inhibits the biosynthesis of cyclic peptides involved in quorum sensing, including gelatinase biosynthesis-activating pheromone (GBAP) in E. faecalis, autoinducing peptide I (AIP-I) in S. aureus, and LsrD698 and LsrD826 in L. innocua. It suppresses abcess formation in a mouse model of skin infection induced by methicillin-resistant S. aureus (MRSA) when adminis...
T10901	Curcumin-d6 Turmeric yellow D6,Natural Yellow 3 D6,Curcumin D6,Diferuloylmethane D6	Others	Others
	Curcumin D6 (difluoroformylmethane D6) is deuterium-labeled curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with various pharmacological effects, including anti-inflammatory, antioxidant, anti-proliferative and anti-a
T75500	Batzelladine D
	Batzelladine D (Compound 1) 是一种 Pdr5p 转运蛋白催化活性和功能活性的抑制剂。Batzelladine D 抑制 Pdr5p ATPase 活性，IC50值为 7.1 µM。Batzelladine D 具有抗真菌 (antifungal)、抗寄生虫 (antiparasitic)、抗病毒 (antiviral)、抗细菌 (antibacterial) 和抗肿瘤活性。
T80383	EP3
	EP3是一种具有抗细菌和抗真菌活性的抗菌肽。该化合物对E. gallinarum、P. pyocyanea、A. baumanii、K. terrigena展示出MIC值为11.4 μg/mL的抑制效果。EP3也显示了对癌细胞的抗肿瘤作用，并能诱导细胞凋亡(apoptosis)。
T36746	Leoidin
	Leoidin is a depsidone originally isolated from L. gangaleoides that has antibacterial and enzyme inhibitory activities.1,2,3 It is active against the bacteria E. faecalis, H. influenzae, M. catarrhalis, S. aureus, and S. pneumoniae (MICs = 8, 32, 1, 128, and 64 μg/ml, respectively).2 Leoidin inhibits phenylalanyl-tRNA synthetase (PheRS) isolated from P. aeruginosa (IC50 = 42 μM). It also inhibits organic anion-transporting polypeptide 1B1 (OATP1B1) and OATP1B3 with Ki values of 0.08 and 1.84 μM...
T35771	Destruxin B2
	Destruxin B2 is a cyclic hexadepsipeptide mycotoxin that has been found in M. anisopliae and has antiviral, insecticidal, and phytotoxic activities.1,2,3 It inhibits secretion of hepatitis B virus surface antigen (HBsAg) by Hep3B cells expressing hepatitis B virus (HBV) DNA (IC50 = 1.3 μM).1 Destruxin B2 is toxic to Sf9 insect cells in an electric cell-substrate impedance sensing (ECIS) test with a 50% inhibitory concentration (ECIS50) value of 92 μM.4 It is also phytotoxic to B. napus leaves.3 ...
T73366	BLK-IN-2
	BLK-IN-2为一种高效、选择性且不可逆的B-淋巴酪氨酸激酶(BLK)抑制剂，具有5.9 nM的IC50值。该化合物亦能抑制BTK，其IC50值为202.0 nM。BLK-IN-2在多种淋巴瘤细胞中展现出显著的抗增殖作用。

化合物

Cat.No: T9231

Target: Antiviral

Cat.No: T4197

Synonym: HZ1157,DHFR-inhibitor

Target: HCV Protease

11β-HSD1 inibitor 19

Cat.No: T72022

N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride

Cat.No: T16169

Synonym: N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride

Target: Others, Proteasome, COX

Cat.No: T9907

Target: PD-1/PD-L1

Cat.No: T21593

Target: VEGFR

Cat.No: T0094

Synonym: Entocort,Pulmicort,布地奈德,Rhinocort

Target: Glucocorticoid Receptor

Cat.No: T7218

Synonym: 内吗啡肽 2

Target: Opioid Receptor

Cat.No: T32535

Synonym: TV-3326,Ladostigil,TV 3326,TV3326,Ladostigil free base

Target: Antioxidant, MAO, AChE

Cat.No: T35900

Synonym: JAK2-IN-7

Target: JAK

Cat.No: T32191

Synonym: CEP-26401,CEP 26401,CEP26401

Target: Histamine Receptor

Halobetasol propionate

Cat.No: T6529

Synonym: 卤贝他索丙酸酯,Halobetasol Propionate,Ulobetasol propionate,BMY-30056,卤倍他索丙酸酯,CGP-14458

Target: Phospholipase

Cat.No: T28533

Synonym: RH-01617,RH 01617

Hydrocarbon chain derivative 1

Cat.No: T10016

Synonym: 6,6'-Oxybis[2,2-dimethyl-1-hexanol]

Target: Others

Cat.No: T32371

Synonym: Chepirol,RN 0308507,Chebutan,Chetazolidin,Chetil

Cat.No: T24431

Cat.No: T71377

Cat.No: T71376

Cat.No: T36484

Synonym: BCL6-IN-4

Cat.No: T39966

Synonym: SGLT1/2-IN-2

Cat.No: T40903

Cat.No: T40447

Cat.No: T69872

Tubulin inhibitor 12

Cat.No: T61242

Cat.No: T11396

Target: Transferase

FGTI-2734 mesylate (1247018-19-4 free base)

Cat.No: T11282L

Synonym: FGTI-2734 mesylate

Target: Others

Tyrosinase/elastase-IN-1

Cat.No: T74243

(5E)-7-Oxozeaenol

Cat.No: T35438

Cat.No: T80363

Cat.No: T61415

Cat.No: T61272

6,9-Dichloro-1,2,3,4-tetrahydroacridine

Cat.No: T35975

Neuraminidase-IN-8

Cat.No: T61509

Cat.No: T16565

Target: Others

Cat.No: T79538

Cat.No: T60921

Cat.No: T38800

Cat.No: T35798

Cat.No: T80365

Cat.No: T61476

Cat.No: T81777

Cat.No: T63696

Cat.No: T80367

Cat.No: T71860

Cat.No: T10901

Synonym: Turmeric yellow D6,Natural Yellow 3 D6,Curcumin D6,Diferuloylmethane D6

Target: Others

Cat.No: T75500

Cat.No: T80383

Cat.No: T36746

Cat.No: T35771

Cat.No: T73366

Cat. No.	Product Name	Target	Signaling Pathways
TN1073	Nuezhenidic acid 女贞子酸,女贞酸	Influenza Virus	Microbiology/Virology
	Nuezhenidic acid 是分离自Ligustrum lucidum 中，具有抑制流感病毒 A 作用。
T3819	Ursolic acid acetate 熊果酸乙酸酯,Acetylursolic acid,3-Acetylursolic Acid	AChE	Neuroscience
	Ursolic acid acetate (Acetylursolic acid) 分离于 Ficus microcarpa 的气根中，对 KB 细胞显示细胞毒性(IC50:8.4 μM)。
T5S1026	Apigenin-7-glucuronide Apigenin 7-O-glucuronide,芹菜素-7-葡萄糖醛酸	MMP	Proteases/Proteasome
	Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) 能够抑制基质金属蛋白酶的活性，其对 MMP-3 (IC50:12.87 μM)，MMP-8 (IC50:22.39 μM)，MMP-9 (IC50:17.52 μM)，MMP-13 (IC50:0.27 μM)。
TN1256	3-O-Acetyl-16α-hydroxytrametenolic acid 3-O-乙酰基-16Α-羟基-氢化松苓酸,3-O-Acetyl-16 alpha-hydroxytrametenolic acid	Immunology/Inflammation related	Immunology/Inflammation
	3-O-Acetyl-16α-hydroxytrametenolic acid 是茯苓中的一种萜类物质，具有抗氧化、抗癌作用。
TN1723	Hamaudol	COX	Immunology/Inflammation; Neuroscience
	Hamaudol 是从防风中分离出的一种色酮，有抗炎作用，可用于缓解疼痛的研究。它抑制环加氧酶COX-1和COX-2的活性，IC50值分别为 0.30 和 0.57 mM。
T6407	β-Lapachone 3,4-二氢-2,2-二甲基-2H-萘并[1,2-B]吡喃-5,6-二酮,Beta-Lapachone,NSC-26326,SL-11001,ARQ-501	IDO; Apoptosis; Topoisomerase; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism
	β-Lapachone (ARQ-501) 是一种萘醌类天然产物，是拓扑异构酶 I 抑制剂，通过抑制细胞周期进程来诱导细胞凋亡。
T4S0217	HOMOPLANTAGININ	TNF; NF-κB	Apoptosis; NF-κB
	Homoplantaginin 是来自中药荔枝草的一种类黄酮，具有抗炎和抗氧化活性。
TN2277	Torachrysone-8-O-b-D-glucoside 芦荟大黄素 8-葡萄糖甙,Torachrysone 8-O-glucoside	Antifection	Microbiology/Virology
	Torachrysone-8-O-b-D-glucoside 可从 Polygonum multiflorum 分离得到。它对 DPCs(真皮乳头细胞)的增殖具有促进作用。
TN1928	Methyl rosmarinate	MMP; Anti-infection; Tyrosinase	Microbiology/Virology; Proteases/Proteasome
	Methyl rosmarinate 是一种非竞争性 tyrosinase 抑制剂，从 Rabdosia serra 中分离得到的，对蘑菇酪氨酸酶作用的 IC50值为 0.28 mM，也能抑制a-glucosidase。
T3S1089	Phillygenin Epipinoresinol methyl ether,(+)-Phillygenin,Phillygenol,Sylvatesmin,Forsythigenol,连翘脂素	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Phillygenin (Sylvatesmin) 是一种连翘的活性组分，有很多的药用价值，包括抗氧化剂，降血脂，抑制低密度脂蛋白氧化。
T10017	1-Linoleoyl Glycerol Glycerol 1-monolinolate,Monolinolein,一亚油酸甘油酯,Glyceryl monolinoleate,1-Linoleoyl-rac-glycerol	Phospholipase	Metabolism
	1-Linoleoyl Glycerol (Monolinolein) 是脂肪酸甘油。
TN1860	Licoflavone B 甘草黄酮 B,甘草黄酮B	ATPase; Anti-infection; Parasite	Membrane transporter/Ion channel; Microbiology/Virology
	Licoflavone B 是从甘草中得到的一种类黄酮，抑制曼氏血吸虫 ATPase 和 ADPase 的活性，IC50值分别为 23.78 µM 和 31.50 µM。
T11218	ε-Viniferin epsilon-Viniferin,Epsilon-白藜芦醇脱氢二聚体	P450	Metabolism
	ε-Viniferin (epsilon-Viniferin) 提取自 Vitis vinifera，是 Resveratrol 的二聚体，能够抑制 CYP 家族,其 Ki=0.5~20 μM，具有抗氧化作用。
TN1273	7,4'-Dihydroxyflavone 4',7-Dihydroxyflavone,7,4'-二羟基黄酮	NF-κB; COX; HDAC; CCR; NOD	Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB
	7,4'-Dihydroxyflavone (4',7-Dihydroxyflavone) 是从甘草中分离的类黄酮，是 eotaxin/CCL11抑制剂，抑制嗜酸性粒细胞趋化因子产生。它通过调节 NF-κB、STAT6 和 HDAC2，抑制 MUC5A 基因表达和粘液产生。
T2S0389	Emodin-1-O-β-D-glucopyranoside 大黄素-1-O-Β-D-吡喃葡萄糖苷,大黄素-1-O-β-D-葡萄糖苷,Emodin-1-O-glucoside	Others	Others
	Emodin-1-O-β-D-glucopyranoside (Emodin-1-O-glucoside) 是一种非竞争性细菌神经氨酸酶抑制剂，IC50为 0.85 μM，提取自药用植物虎杖中。
T3S1196	mogroside IV	Others	Others
	Mogroside IV 是一种从罗汉果提取物中分离得到的三萜糖苷。它是非糖类甜味剂，甜度比蔗糖高。它具有抗氧化，抗糖尿病和抗癌作用。
T6S1369	Vitexin 牡荆素,Apigenin-8-C-glucoside	Antioxidant	oxidation-reduction
	Vitexin 是一种存在于多种药用植物（如榕树、螺旋藻）中的 c-糖基化的黄酮。它具有广泛的药理作用，包括抗氧化，抗癌，抗炎，抗痛觉过敏和神经保护作用。
T5758	sphondin 6-甲氧基当归素,牛防风素,牛防风素	COX; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Sphondin 具有抗惊厥、抗炎和抗增殖活性，对 IL-1beta 诱导的 A549 细胞中 COX-2 蛋白水平和 PGE(2) 释放的增加具有抑制作用。
T4S1718	Punicalin	HBV; HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Punicalin 是从Punica granatumL. 或Terminalia catappaL. 的叶子中分离的，一种可水解的单宁，具有抗炎活性。它是一种抗乙型肝炎病毒药物。
T3666	Atractylodin 苍术素,Atractydin	Lipid	Metabolism
	Atractylodin (Atractydin) 是一种Atractylodes lancea 和A. chinensis 的根茎中所含精油的活性成分。它是天然杀虫剂，能够抑制Tribolium castaneum 的活性。
TN1661	Ganoderic acid C2 灵芝酸 C2	Reductase; Histamine Receptor; Immunology/Inflammation related	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Ganoderic acid C2 是分离自灵芝的一种三萜化合物，具有潜在的抗肿瘤生物活性，以及抗组胺、抗衰老和细胞毒性作用。它对rat lens aldose reductase 具有很高的抑制活性，IC50为 3.8 µM。
TN1100	Nepodin	transporter; COX; AMPK; Parasite	Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling
	Nepodin 是从Rumex crispus 中分离的一种醌氧化还原酶抑制剂，具有抗糖尿病和抗疟疾的作用。。它通过激活 AMPK 刺激 GLUT4 向质膜的转运。
T2851	Daphnetin 7,8-Dihydroxycoumarin,Daphnetol,瑞香素	EGFR; PKA; PKC; Parasite; Autophagy	Angiogenesis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Daphnetin (7,8-Dihydroxycoumarin) 是从 Genus Daphne 中分离得到的香豆素衍生物，有抗氧化、抗炎、抗疟疾和解热作用，可用于凝血功能障碍、类风湿性关节炎等疾病的相关研究。
TN1433	Batatasin III	FAK; Others; Akt	Angiogenesis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Batatasin III 通过抑制上皮间质转化和 FAK-AKT 信号来抑制癌症迁移和侵袭，并具有抗癌活性。 Batatasin III 对整株生长有长期抑制作用，显示出抑制萌发活性。
T5S0993	Kurarinone 苦参酮,苦参黄素	BCL; Others; IκB/IKK; TNF; NF-κB; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; Others; Stem Cells
	Kurarinone 是从灌木苦参中提取的黄酮类化合物，具有抗肿瘤、雌激素和抗炎活性，对免疫反应也有很强的抑制作用。
T0962	L-Hyoscyamine Daturine,Hyoscyamine,L-莨菪碱,L-天仙子胺	AChR	Neuroscience
	L-Hyoscyamine (Daturine) 是从山莨菪中提取的一种托烷生物碱，是竞争性的毒蕈碱受体拮抗剂。它是 Atropine 的左旋异构体。
T5S2059	Glaucine	Calcium Channel; Dopamine Receptor; Influenza Virus; Adrenergic Receptor; PDE	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	Glaucine 是从海罂粟中分离的一种生物碱，具有镇咳、抗炎和支气管扩张作用。它是具有口服活性的磷酸二酯酶 4 选择性抑制剂。它还是非选择性的 α-肾上腺素受体拮抗剂，具有抗氧化和抗病毒活性。
T2S0618	β-Elemonic Acid 3-oxo Tirucallic Acid,β-岚香酮酸,Beta-Elemonic acid,3-Oxotirucallenoic Acid,β-榄香酮酸,Elemadienonic Acid	Apoptosis; Reactive Oxygen Species; COX	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	β-Elemonic Acid (3-Oxotirucallenoic Acid) 是从乳香树中分离得到的一种三萜，具有抗癌和抗炎作用。它抑制脯氨酰内肽酶，诱导细胞凋亡，活性氧和COX-2表达。
T4S1619	L-Hyoscyamine sulfate Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate,硫酸天仙子胺水合物,L-莨菪碱硫酸盐	AChR	Neuroscience
	L-Hyoscyamine sulfate (Levsin Sulfate) 是来自山莨菪的一种托烷生物碱，是竞争性的毒蕈碱受体拮抗剂。它是 Atropine 的左旋异构体。
T2979	DL-Menthol DL-薄荷醇,Hexahydrothymol,(±)-Menthol,薄荷醇	GABA Receptor; AChE	Membrane transporter/Ion channel; Neuroscience
	DL-Menthol ((±)-Menthol) 是单萜醇 (–)-薄荷醇和 (+)-薄荷醇的外消旋混合物，已在大麻中发现。它与 GABAA 受体的激活有关。
TN1905	Magnolioside 七叶苷甲基醚,6-甲氧基香豆素-7-0-BETA-D-吡喃葡萄糖苷	Antifection	Microbiology/Virology
	Magnolioside 是分离自Angelica gigas Nakai(Umbelliferae) 中，对谷氨酸诱导的毒性有显著的神经保护作用。它显示出对金黄色葡萄球菌 CIP 53.154 的中等抗菌活性。它具有抗疟原虫活性，对氯喹敏感的恶性疟原虫菌株具有强烈的生长抑制作用。
T7028	Licochalcone C LICOCHALCONEC,甘草查尔酮C	Phosphatase; Antioxidant; Glucosidase	Metabolism; oxidation-reduction
	Licochalcone C (LICOCHALCONEC) 能够抑制 α-葡萄糖苷酶，其对 α-葡萄糖苷酶的 IC50 <100 nM，对蛋白酪氨酸磷酸酶 1B 的 IC50=92.43 μM 。
TL0005	3,5-O-Dicaffeoylquinic acid Isochlorogenic Acid A,(-)-3,5-二咖啡酰奎宁酸,(-)-3,5-Dicaffeoyl quinic acid,3,5-Dicaffeoylquinic Acid	Others	Others
	3,5-O-Dicaffeoylquinic acid (Isochlorogenic Acid A) 能够改善由三甲基锡诱导的学习和记忆缺陷。
T3123	Allicin	ERK; IL Receptor; Others; IκB/IKK; p38 MAPK; TNF; ROS; Caspase; Antifection	Apoptosis; Immunology/Inflammation; MAPK; Microbiology/Virology; NF-κB; Others; Proteases/Proteasome
	Allicin 具有抗氧化、杀菌、抗癌、抗炎活性，对肠上皮细胞具有抑制性免疫调节作用。 Allicin 能显着抑制胰岛素诱导的血管平滑肌细胞的增殖和迁移，这可能与抑制 ERK 信号通路的激活有关。 Allicin 有利于降低高胆固醇血症大鼠的血液胆固醇、甘油三酯水平和收缩压，它可能有益于影响动脉粥样硬化的两个危险因素——高脂血症和高血压。
T6S1699	Shogaol [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol	Lipoxygenase; Autophagy	Autophagy; Metabolism
	6-Shogaol (6-Shogaol) 是从生姜中分离的一种天然产物，具有抗癌、抗炎和抗氧化的多种生物活性。
T3S1612	kuwanon G 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G	Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂，具有杀菌作用。
T2S0843	Negletein 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether	IL Receptor; TNF; NOS; Interleukin	Apoptosis; Immunology/Inflammation
	Negletein (7-O-Methylbaicalein) 一种神经保护剂，可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性，其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。
TMA0164	15-Hydroxydehydroabietic acid	P450; Antifection	Metabolism; Microbiology/Virology
	15-Hydroxydehydroabietic acid exhibits a promising alpha-glucosidase inhibitory activity, it also shows significant antibacterial activities.
TN4752	Perilloxin	COX	Immunology/Inflammation; Neuroscience
	Perilloxin possesses inhibitory activities against cyclooxygenase-1,with IC(50) values of 23.2 microM.
TN3964	Epiaschantin	Others	Others
	(+)-Epiaschantin shows marginal cancer cell line inhibitory activities. It also has anti-platelet aggregation activity.
TN2288	Uralenol 乌拉尔醇	Others; Estrogen/progestogen Receptor; Tyrosinase	Endocrinology/Hormones; Others; Proteases/Proteasome
	Uralenol significantly shows the inhibitory activities against the PTP1B enzyme; it also shows inhibitory activities on mushroom tyrosinase using l-tyrosine as substrate( IC50 =49.5 μM). Uralenol shows potent anti-proliferation effects on ER-positive breast cancer MCF-7 cells in vitro.
TMA1890	Icariside F2 淫羊藿次苷F2	NF-κB	NF-κB
	Icariside F2 shows modest α-glucosidase inhibitory (4.60±1.74% to 11.97±3.30%) and antioxidant activities. It also displays potent NF-ÎºB inhibitory effects, with the IC50 value of 16.25 ± 2.19 uM.
TN2505	1,5-Diphenylpentan-1-one	AChR	Neuroscience
	1,5-Diphenylpentan-1-one shows poor insecticidal and acetylcholinesterase inhibitory activities.
TC0017	Haplopine	Tyrosinase; Antifection	Microbiology/Virology; Proteases/Proteasome
	Haplopine shows photo-activated antimicrobial activity against S. aureus. It exhibits potent melanogenesis-inhibitory activities with almost no toxicity to the cells.
TMA0593	Broussoflavonol F	Tyrosinase	Proteases/Proteasome
	Broussoflavonol F has antiplatelet effect, is partially due to an inhibitory effect on cyclooxygenase, can inhibit arachidonic acid (AA)-induced platelet aggregation. Broussoflavonol F shows inhibitory activities on mushroom tyrosinase. Broussoflavonol F
TN4331	Isotachioside	Lipoxygenase	Metabolism
	Isotachioside has15-lipoxygenase (15-LO) inhibitory activities.
TN4732	Pachysamine M	Others	Others
	Pachysamine M shows inhibitory activities against multiple types of cancer cells.
TN5090	Tachioside	Glucokinase	Metabolism
	Tachioside has antiobesity, antioxidant and α-glucosidase inhibitory activities, it decreases lipid content in 3T3-L1 adipocytes by inhibiting lipogenesis, shows antiobesity activities. Tachioside can inhibit nitric oxide production in lipopolysaccharides-stimulated RAW 264.7 cells with IC50 value of 12.14 μM.
TN2025	Oxyresveratrol 2-O-β-D-glucopyranoside 氧化白藜芦醇-2-O-Β-D-吡喃葡萄糖苷,Oxyresveratrol 2-O-beta-D-glucopyranoside	Others; Tyrosinase	Others; Proteases/Proteasome
	Oxyresveratrol-2-O-beta-D-glucopyranoside shows better tyrosinase inhibitory activities than kojic acid.
TN5146	Thunalbene	Others	Others
	Thunalbene shows weak inhibitory activities without cytotoxicity on the production of nitric oxide (NO) which is an important inflammatory mediator.
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天然产物

Nuezhenidic acid

Cat.No: TN1073

Synonym: 女贞子酸,女贞酸

Target: Influenza Virus

Ursolic acid acetate

Cat.No: T3819

Synonym: 熊果酸乙酸酯,Acetylursolic acid,3-Acetylursolic Acid

Target: AChE

Apigenin-7-glucuronide

Cat.No: T5S1026

Synonym: Apigenin 7-O-glucuronide,芹菜素-7-葡萄糖醛酸

Target: MMP

3-O-Acetyl-16α-hydroxytrametenolic acid

Cat.No: TN1256

Synonym: 3-O-乙酰基-16Α-羟基-氢化松苓酸,3-O-Acetyl-16 alpha-hydroxytrametenolic acid

Target: Immunology/Inflammation related

Cat.No: TN1723

Target: COX

Cat.No: T6407

Synonym: 3,4-二氢-2,2-二甲基-2H-萘并[1,2-B]吡喃-5,6-二酮,Beta-Lapachone,NSC-26326,SL-11001,ARQ-501

Target: IDO, Apoptosis, Topoisomerase, Autophagy

HOMOPLANTAGININ

Cat.No: T4S0217

Target: TNF, NF-κB

Torachrysone-8-O-b-D-glucoside

Cat.No: TN2277

Synonym: 芦荟大黄素 8-葡萄糖甙,Torachrysone 8-O-glucoside

Target: Antifection

Methyl rosmarinate

Cat.No: TN1928

Target: MMP, Anti-infection, Tyrosinase

Cat.No: T3S1089

Synonym: Epipinoresinol methyl ether,(+)-Phillygenin,Phillygenol,Sylvatesmin,Forsythigenol,连翘脂素

Target: Reactive Oxygen Species

1-Linoleoyl Glycerol

Cat.No: T10017

Synonym: Glycerol 1-monolinolate,Monolinolein,一亚油酸甘油酯,Glyceryl monolinoleate,1-Linoleoyl-rac-glycerol

Target: Phospholipase

Cat.No: TN1860

Synonym: 甘草黄酮 B,甘草黄酮B

Target: ATPase, Anti-infection, Parasite

Cat.No: T11218

Synonym: epsilon-Viniferin,Epsilon-白藜芦醇脱氢二聚体

Target: P450

7,4'-Dihydroxyflavone

Cat.No: TN1273

Synonym: 4',7-Dihydroxyflavone,7,4'-二羟基黄酮

Target: NF-κB, COX, HDAC, CCR, NOD

Emodin-1-O-β-D-glucopyranoside

Cat.No: T2S0389

Synonym: 大黄素-1-O-Β-D-吡喃葡萄糖苷,大黄素-1-O-β-D-葡萄糖苷,Emodin-1-O-glucoside

Target: Others

Cat.No: T3S1196

Target: Others

Cat.No: T6S1369

Synonym: 牡荆素,Apigenin-8-C-glucoside

Target: Antioxidant

Cat.No: T5758

Synonym: 6-甲氧基当归素,牛防风素,牛防风素

Target: COX, Prostaglandin Receptor

Cat.No: T4S1718

Target: HBV, HIV Protease

Cat.No: T3666

Synonym: 苍术素,Atractydin

Target: Lipid

Ganoderic acid C2

Cat.No: TN1661

Synonym: 灵芝酸 C2

Target: Reductase, Histamine Receptor, Immunology/Inflammation related

Cat.No: TN1100

Target: transporter, COX, AMPK, Parasite

Cat.No: T2851

Synonym: 7,8-Dihydroxycoumarin,Daphnetol,瑞香素

Target: EGFR, PKA, PKC, Parasite, Autophagy

Cat.No: TN1433

Target: FAK, Others, Akt

Cat.No: T5S0993

Synonym: 苦参酮,苦参黄素

Target: BCL, Others, IκB/IKK, TNF, NF-κB, JAK, STAT

Cat.No: T0962

Synonym: Daturine,Hyoscyamine,L-莨菪碱,L-天仙子胺

Target: AChR

Cat.No: T5S2059

Target: Calcium Channel, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, PDE

β-Elemonic Acid

Cat.No: T2S0618

Synonym: 3-oxo Tirucallic Acid,β-岚香酮酸,Beta-Elemonic acid,3-Oxotirucallenoic Acid,β-榄香酮酸,Elemadienonic Acid

Target: Apoptosis, Reactive Oxygen Species, COX

L-Hyoscyamine sulfate

Cat.No: T4S1619

Synonym: Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate,硫酸天仙子胺水合物,L-莨菪碱硫酸盐

Target: AChR

Cat.No: T2979

Synonym: DL-薄荷醇,Hexahydrothymol,(±)-Menthol,薄荷醇

Target: GABA Receptor, AChE

Cat.No: TN1905

Synonym: 七叶苷甲基醚,6-甲氧基香豆素-7-0-BETA-D-吡喃葡萄糖苷

Target: Antifection

Cat.No: T7028

Synonym: LICOCHALCONEC,甘草查尔酮C

Target: Phosphatase, Antioxidant, Glucosidase

3,5-O-Dicaffeoylquinic acid

Cat.No: TL0005

Synonym: Isochlorogenic Acid A,(-)-3,5-二咖啡酰奎宁酸,(-)-3,5-Dicaffeoyl quinic acid,3,5-Dicaffeoylquinic Acid

Target: Others

Cat.No: T3123

Target: ERK, IL Receptor, Others, IκB/IKK, p38 MAPK, TNF, ROS, Caspase, Antifection

Cat.No: T6S1699

Synonym: [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol

Target: Lipoxygenase, Autophagy

Cat.No: T3S1612

Synonym: 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G

Target: Phosphatase, Antibacterial, Bombesin Receptor, AChR, AChE, Glucosidase

Cat.No: T2S0843

Synonym: 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether

Target: IL Receptor, TNF, NOS, Interleukin

15-Hydroxydehydroabietic acid

Cat.No: TMA0164

Target: P450, Antifection

Cat.No: TN4752

Target: COX

Cat.No: TN3964

Target: Others

Cat.No: TN2288

Synonym: 乌拉尔醇

Target: Others, Estrogen/progestogen Receptor, Tyrosinase

Cat.No: TMA1890

Synonym: 淫羊藿次苷F2

Target: NF-κB

1,5-Diphenylpentan-1-one

Cat.No: TN2505

Target: AChR

Cat.No: TC0017

Target: Tyrosinase, Antifection

Broussoflavonol F

Cat.No: TMA0593

Target: Tyrosinase

Cat.No: TN4331

Target: Lipoxygenase

Cat.No: TN4732

Target: Others

Cat.No: TN5090

Target: Glucokinase

Oxyresveratrol 2-O-β-D-glucopyranoside

Cat.No: TN2025

Synonym: 氧化白藜芦醇-2-O-Β-D-吡喃葡萄糖苷,Oxyresveratrol 2-O-beta-D-glucopyranoside

Target: Others, Tyrosinase

Cat.No: TN5146

Target: Others

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