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Search Results for " type-4 "

135

抑制剂 & 化合物

28

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T14496	BAMB-4 ITPKA-IN-C14	Others	Others
	BAMB-4 (ITPKA-IN-C14) 是一种新型的膜渗透型ITPKA 抑制剂，在ADP-Glo 实验中的IC50值为37uM。
T0314	Hexylresorcinol 己雷锁辛,4-己基间苯二酚,4-Hexylresorcinol	Apoptosis; Tyrosinase; Antibacterial; Parasite	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Hexylresorcinol (4-Hexylresorcinol) 是在植物中发现的一种天然产物，具有抗菌、驱虫、防腐和抗肿瘤活性。它是一种可逆、非竞争性的 α-葡萄糖苷酶抑制剂，有抗 DNA 氧化损伤的保护作用。它可诱导鳞癌细胞凋亡。
T3184	Kevetrin hydrochloride Thioureidobutyronitrile HCl,thioureido butyronitrile hydrochloride,4-Isothioureidobutyronitrile hydrochloride	Mdm2; p53	Apoptosis
	Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) 是一种小分子，是肿瘤抑制蛋白 p53 的激活剂，具有潜在的抗肿瘤活性。
T12302	OMDM-1 (Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide	Endogenous Metabolite	Metabolism
	OMDM-1 ((Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide) 是有效选择性的代谢稳定 anandamide 细胞摄取抑制剂，Ki=为2.4 μM。
T5354	IRAK4-IN-7 CA-4948	IRAK	Immunology/Inflammation; NF-κB
	IRAK4-IN-7 (CA-4948) 是白介素 1 受体相关激酶 4 (IRAK4) 的选择性抑制剂，口服有活性。它可用于研究癌症以及炎症疾病。
T2923	Apremilast 阿普斯特,CC-10004,阿普司特	Apoptosis; TNF; PDE	Apoptosis; Metabolism
	Apremilast (CC-10004) 是一种口服有效的磷酸二酯酶 4 抑制剂，IC50为 74 nM。它抑制脂多糖释放TNF-α，IC50为 104 nM。
T7369L	Gemigliptin Tartrate(911637-19-9 free base) 吉格列汀酒石酸盐,LC15-0444 tartrate	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Gemigliptin Tartrate (LC15-0444 tartrate) 是一种选择性的，可逆的，竞争性的二肽基肽酶 4 (DPP-4) 抑制剂，对于人重组 DPP-4 的IC50=10.3 nM。Gemigliptin tartrate 具有很强的抗糖基化活性，能够用于晚期糖基化终产物相关的糖尿病并发症的研究。
T6146	Dorsomorphin dihydrochloride BML-275 2HCl,Compound C dihydrochloride,6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶,Dorsomorphin (Compound C) 2HCl,Compound C 2HCl,BML-275 dihydrochloride	AMPK; Autophagy; TGF-beta/Smad	Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling; Stem Cells
	Dorsomorphin dihydrochloride (BML-275 2HCl) 是一种选择性和 ATP 竞争性的AMPK 抑制剂，Ki 为 109 nM。它诱导自噬，通过靶向抑制 I 型受体ALK2，ALK3和ALK6来抑制 BMP 途径。
TP1878L	PACAP 1-38 acetate	PACAP	GPCR/G Protein
	PACAP 1-38 acetate 是一种垂体腺苷酸环化酶激活多肽 (PACAP) 类似物。它与 PACAP I 型受体 (IC50 = 4 nM) 和 PACAP II 型 VIP2 受体 (IC50 = 1 nM) 结合，但不与 PACAP II 型 VIP1 受体结合。
T4462	Roflumilast N-oxide	PDE	Metabolism
	Roflumilast N-oxide 是一种 PDE 4 型抑制剂。
T29019	TS-021 TS021,TS 021,TS-021 Free	DPP-4	Proteases/Proteasome
	TS-021 是一种具有选择性的二肽基肽酶 4 (DPP-4) 抑制剂，具有抗糖尿病活性，可用于研究2 型糖尿病。
T26698	AZ044	PI4K	PI3K/Akt/mTOR signaling
	AZ044是 III 型磷脂酰肌醇-4-激酶α -亚型(PI4KIIIalpha)的有效选择性抑制剂。
T12710	Retagliptin Phosphate SP 2086,瑞格列汀磷酸盐	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Retagliptin Phosphate (SP 2086) 是一种选择性、竞争性、口服活性的二肽基肽酶 4 (DPP-4) 抑制剂。Retagliptin phosphate 能够用于 2 型糖尿病 (T2DM) 的研究。
T64377	AGI-41998 tautomers	Others	Others
	AGI-41998 tautomers 是pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-[(2,2,2-trifluoroethyl)amino]-. pyrido[4,3-d]pyrimidin-7(6H)-one 的互变异构体。pyrido[4,3-d]pyrimidin-7(6H)-one, 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-[(2,2,2-trifluoroethyl)amino]-. pyrido[4,3-d]pyrimidin-7(6H)-one 是S-adenosylmethionine synthase isoform type-2抑制剂, IC50= 0.022μM。
T9906	Ipilimumab	Others	Others
	Ipilimumab 是全人类单克隆抗体 IgG1κ，能够抗 CTLA-4。其中CTLA-4是一种由活化的 T 细胞产生的免疫抑制分子。
T67837	(3S)-GSK-F1 PI4KA inhibitor-F1	PI4K	PI3K/Akt/mTOR signaling
	(3S)-GSK-F1是一种选择性PI4KIIIα抑制剂，pIC50=8.3。
T3476	JI-101 CGI-1842,JI 101	VEGFR; PDGFR; Ephrin Receptor	Angiogenesis; Tyrosine Kinase/Adaptors
	JI-101 (CGI-1842) 是一种有口服活性的多靶点激酶抑制剂，能够抑制VEGFR2，PDGFRβ和EphB4，具有抗癌作用。
T2296	Trelagliptin succinate 曲格列汀琥珀酸盐,琥珀酸曲格列汀,SYR-472 succinate,SYR472	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Trelagliptin succinate (SYR-472 succinate) 是一种有效的，具有口服活性的DPP-4抑制剂，IC50=4 nM。它可以改善体内血糖控制，能够用于2 型糖尿病(T2DM) 的研究。
T7133	Anagliptin SK-0403,阿拉格列汀	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Anagliptin (SK-0403) 是一种选择性的二肽酰肽酶 4 抑制剂，IC50=3.8 nM，对 DPP-8/9 的选择性相对较弱，IC50分别为 68 和 60 nM。
T2677	Crenolanib ARO 002,CP-868596	FLT; PDGFR; Autophagy	Angiogenesis; Autophagy; Tyrosine Kinase/Adaptors
	Crenolanib (ARO 002) 是一种口服生物可利用的 III 型酪氨酸激酶抑制剂，抑制 FLT3和 PDGFRα/β的 IC50分别为 4、11和 3.2 nM。
T24905	TT01001 TT-01001,TT 01001,Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate	Mitochondrial Metabolism	Metabolism
	TT01001 (Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate) 是 mitoNEET 的选择性激动剂，通过改善线粒体功能障碍来减少氧化应激损伤和神经元凋亡。 TT01001可用于治疗 II 型糖尿病的研究。
T68053	Denagliptin GW823093	DPP-4	Proteases/Proteasome
	Denagliptin是一种小分子二肽基肽酶IV（DPP-4）抑制剂，可用于治疗内分泌于代谢疾病，可用于研究2型糖尿病。
T60248	4-Aminobenzamidine dihydrochloride p-Aminobenzamidine dihydrochloride	Serine Protease	Proteases/Proteasome
	4-Aminobenzamidine dihydrochloride (p-Aminobenzamidine dihydrochloride) 是一种强胰蛋白酶 (trypsin)抑制剂，也是一种相对较弱的尿激酶型纤溶酶原激活剂 (uPA) 抑制剂 (Ki=82 μM)。4-Aminobenzamidine 可抑制 SCID 小鼠体内前列腺肿瘤的生长。
T6900	MS023	Histone Methyltransferase	Chromatin/Epigenetic
	MS023 是一种有效的、选择性的、细胞活性的 I 型 PRMT 抑制剂，对 PRMT1、PRMT3、PRMT4、PRMT6和 PRMT8的 IC50分别为 30、119、83、4 和 5 nM。
T16164	MY-5445 N-(3-chlorophenyl)-4-phenylphthalazin-1-amine	PDE	Metabolism
	MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) 是特异性的 cGMP 磷酸二酯酶 PDE5抑制剂，其 Ki=1.3 μM。它是一种 ABCG2转运蛋白调节剂，具有抗增殖活性。它能抑制人血小板凝集。
T10776	CFTR corrector 4	CFTR	Membrane transporter/Ion channel
	CFTR corrector 4是一种高效且可口服的囊性纤维化跨膜电导调节剂 (CFTR)，是一种有效的 (R，R) 型活性对映体。CFTR corrector 4 可以增加细胞表面的 CFTR 水平，是用来研究囊性纤维化的潜在化合物。
T38507	Renzapride BRL 24924	5-HT Receptor	GPCR/G Protein; Neuroscience
	Renzapride (BRL 24924) 是一种混合 5-羟色胺 4 型（5-HT4）激动剂和 5-HT3 受体拮抗剂。Renzapride 可用于研究以便秘为主的肠易激综合征（C-IBS）。
T3188	RE-640	CCR; Parasite	Immunology/Inflammation; Microbiology/Virology
	NSC-5844 (RE-640) 是 4-氨基喹啉衍生物，起抗肿瘤和抗疟疾作用。
T12730	RIPK1-IN-4	RIP kinase	Apoptosis; NF-κB
	RIPK1-IN-4 是有效的 II 型激酶受体相互作用蛋白1 (RIP1) 激酶抑制剂，并且与 DL1-out 无活性形式的 RIP1 结合。RIPK1-IN-4抑制 RIP1 和 ADP-Glo 激酶，IC50 分别是 16 nM 和 10 nM。
T1766	Empagliflozin BI 10773,恩格列净	SGLT	GPCR/G Protein
	Empagliflozin (BI 10773) 是一种 SGLT-2 抑制剂 (IC50=3.1 nM)，具有有效的和选择性，对 SGLT-1/4/5/6 的选择性高 300 倍以上。Empagliflozin 可用于治疗二型糖尿病。
T1291	Cisapride 西沙必利,西沙比利,Prepulsid,R 51619,Pridesia,Kaudalit,(±)-Cisaprid,Kinestase	Potassium Channel; 5-HT Receptor; HER	Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Membrane transporter/Ion channel; Neuroscience; Tyrosine Kinase/Adaptors
	Cisapride (R 51619) 是一种5-HT4受体激动剂，还是 hERG 抑制剂。它可作用于肠道中的血清素受体，促进肠道蠕动，增加胃排空并减少食管反流。
T22324	Ensartinib hydrochloride Ensartinib dihydrochloride,X-396 dihydrochloride	Others; Trk receptor; c-Met/HGFR; ALK	Angiogenesis; Others; Tyrosine Kinase/Adaptors
	Ensartinib hydrochloride (X-396 dihydrochloride) 是双重的 ALK/MET 抑制剂，IC50分别 <0.4 nM 和 0.74 nM。
T11157L	EGFR-IN-1 hydrochloride	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-1 hydrochloride 是 L858R/T790M 突变体 EGFR 的不可逆特异性抑制剂，选择性是野生型 EGFR 的 100 倍。 EGFR-IN-1 hydrochloride 在 H1975 细胞和突变体 HCC827 细胞中表现出有效的抗肿瘤和抗增殖活性，IC50 分别为 4 和 28 nM。
T0242	Sitagliptin 西他列汀,MK0431,西格列汀	Proteasome; DPP-4; Autophagy	Autophagy; Proteases/Proteasome; Ubiquitination
	Sitagliptin (MK0431) 是一种有效的 DPP4抑制剂，在 Caco-2 细胞中，IC50值为 19 nM。它是一种新型口服降糖药，可单独使用或与二甲双胍或噻唑烷二酮联合用于治疗 2 型糖尿病。
T50077	m-Nisoldipine 3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate	Others	Others
	m-Nisoldipine (3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate) 是一种二氢吡啶类钙通道阻滞剂，尼索地平的衍生物，阻断心脏和平滑肌细胞中的 L-型钙通道，用于治疗高血压和心绞痛。
T67896	CB2R/FAAH modulator-1	Cannabinoid Receptor; FAAH	GPCR/G Protein; Metabolism; Neuroscience
	CB2R/FAAH modulator-1是一种大麻素2型受体(CB2R)激动剂，同时也是脂肪酸酰胺水解酶(FAAH)抑制剂（IC50=4 μM），可减少促炎和增加抗炎细胞因子的产生，常用于炎症研究。对 CB2R 和 CB1R 的Kis 分别为14.8 nM 和241.3 nM。
T1024	Roflumilast 罗氟司特,B9302-107,BYK 20869,APTA 2217,BY 217	PDE; RSV	Metabolism; Microbiology/Virology
	Roflumilast (APTA 2217) 是一种口服的长效 4 型磷酸二酯酶抑制剂 (PDE4)，具有抗炎和潜在的抗肿瘤活性，作用于PDE4A1，PDEA4，PDEB1和PDEB2，IC50分别为 0.7，0.9，0.7 和 0.2 nM。
T8970	ML162	Ferroptosis; GPX; Glutathione Peroxidase	Apoptosis; Metabolism; oxidation-reduction
	ML162 是一种共价谷胱甘肽过氧化物酶 4 抑制剂。它选择性抑制表达突变 RAS 癌基因的细胞系。
T6611	NSC697923 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran	E1/E2/E3 Enzyme	Ubiquitination
	NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage ...
T16345	NS13001 N-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine,N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine	Potassium Channel	Membrane transporter/Ion channel
	NS13001 (N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine) 是口服有效的 SK 通道选择性正向变构调节剂。NS13001 对 SK2 和 SK3 通道的 EC50分别为 1.8 μM 和 0.14 μM。NS13001 在脊髓小脑共济失调 2 型和其他小脑共济失调方面具有研究价值。
T36935	PKUMDL-LC-101-D04 GPX4-Activator-1d4,PKUMDL-LC-101-D04	GPX	oxidation-reduction
	PKUMDL-LC-101-D04是一种高效的谷胱甘肽过氧化物酶4（GPX4）的异位激活剂，是一种铁死亡的调节剂。当在无细胞试验中使用浓度为20 μM 时，GPX4活性增加到对照水平的150%；在野生型而非Gpx4-/-小鼠胚胎成纤维细胞(MEF)提取物中使用浓度为61 μM 时，GPX4活性增加到对照水平的150%。PKUMDL-LC-101-D04（200 μM）能减少胆固醇过氧化氢诱导的MEF 死亡。
T26132	RS 14203 RS-14203,RS14203
	RS 14203 is a selective type 4 phosphodiesterase (PDE4) inhibitor.
T26777	Besigliptin Tosylate SHR 117887,SHR-117887,SHR117887
	Besigliptin Tosylate, a DPP-4 inhibitor, is used potentially for the treatment of type 2 diabetes.
T28520	Retagliptin SP-2086,SP2086,SP 2086
	Retagliptin is a DPP-4 inhibitor potentially used to treat Type 2 diabetes.
T15163	DPC-681 DPH-153893	Others	Others
	DPC-681 is a potent and selective HIV protease inhibitor (IC90s: 4 to 40 nM for wild-type HIV-1).
T26857	BMS-767778
	BMS-767778, a DPP-4 inhibitor, is used potentially for the treatment of type 2 diabetes.
T20815	4-Chloroloratadine 4-Chloro loratadine,Loratadine specified impurity C
	4-Chloroloratadine is an impurity of Loratadine, a nonsedating-type histamine H1-receptor.
T26941	Camegliptin RO-4876904-001,R1579,RG1579,RO-4876904,R-1579,RG-1579
	Cameglipti, a dipeptidyl peptidase IV (DPP-4) inhibitor, is used potentially for the treatment of type 2 diabetes.
T11420	GLUT4 activator 1	Others	Others
	GLUT4 activator 1 is a potent glucose transporter type 4 (GLUT4) translocation activator (EC50: 0.14 μM).
T11499	GSK726701A	Others	Others
	GSK726701A is a new type of prostaglandin E2 receptor 4 (EP4) partial agonist (pEC50: 7.4).

化合物

Cat.No: T14496

Synonym: ITPKA-IN-C14

Target: Others

Hexylresorcinol

Cat.No: T0314

Synonym: 己雷锁辛,4-己基间苯二酚,4-Hexylresorcinol

Target: Apoptosis, Tyrosinase, Antibacterial, Parasite

Kevetrin hydrochloride

Cat.No: T3184

Synonym: Thioureidobutyronitrile HCl,thioureido butyronitrile hydrochloride,4-Isothioureidobutyronitrile hydrochloride

Target: Mdm2, p53

Cat.No: T12302

Synonym: (Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide

Target: Endogenous Metabolite

Cat.No: T5354

Synonym: CA-4948

Target: IRAK

Cat.No: T2923

Synonym: 阿普斯特,CC-10004,阿普司特

Target: Apoptosis, TNF, PDE

Gemigliptin Tartrate(911637-19-9 free base)

Cat.No: T7369L

Synonym: 吉格列汀酒石酸盐,LC15-0444 tartrate

Target: Proteasome, DPP-4

Dorsomorphin dihydrochloride

Cat.No: T6146

Synonym: BML-275 2HCl,Compound C dihydrochloride,6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶,Dorsomorphin (Compound C) 2HCl,Compound C 2HCl,BML-275 dihydrochloride

Target: AMPK, Autophagy, TGF-beta/Smad

PACAP 1-38 acetate

Cat.No: TP1878L

Target: PACAP

Roflumilast N-oxide

Cat.No: T4462

Target: PDE

Cat.No: T29019

Synonym: TS021,TS 021,TS-021 Free

Target: DPP-4

Cat.No: T26698

Target: PI4K

Retagliptin Phosphate

Cat.No: T12710

Synonym: SP 2086,瑞格列汀磷酸盐

Target: Proteasome, DPP-4

AGI-41998 tautomers

Cat.No: T64377

Target: Others

Cat.No: T9906

Target: Others

Cat.No: T67837

Synonym: PI4KA inhibitor-F1

Target: PI4K

Cat.No: T3476

Synonym: CGI-1842,JI 101

Target: VEGFR, PDGFR, Ephrin Receptor

Trelagliptin succinate

Cat.No: T2296

Synonym: 曲格列汀琥珀酸盐,琥珀酸曲格列汀,SYR-472 succinate,SYR472

Target: Proteasome, DPP-4

Cat.No: T7133

Synonym: SK-0403,阿拉格列汀

Target: Proteasome, DPP-4

Cat.No: T2677

Synonym: ARO 002,CP-868596

Target: FLT, PDGFR, Autophagy

Cat.No: T24905

Synonym: TT-01001,TT 01001,Ethyl 4-(3-(3,5-dichlorophenyl)thioureido)piperidine-1-carboxylate

Target: Mitochondrial Metabolism

Cat.No: T68053

Synonym: GW823093

Target: DPP-4

4-Aminobenzamidine dihydrochloride

Cat.No: T60248

Synonym: p-Aminobenzamidine dihydrochloride

Target: Serine Protease

Cat.No: T6900

Target: Histone Methyltransferase

Cat.No: T16164

Synonym: N-(3-chlorophenyl)-4-phenylphthalazin-1-amine

Target: PDE

CFTR corrector 4

Cat.No: T10776

Target: CFTR

Cat.No: T38507

Synonym: BRL 24924

Target: 5-HT Receptor

Cat.No: T3188

Target: CCR, Parasite

Cat.No: T12730

Target: RIP kinase

Cat.No: T1766

Synonym: BI 10773,恩格列净

Target: SGLT

Cat.No: T1291

Synonym: 西沙必利,西沙比利,Prepulsid,R 51619,Pridesia,Kaudalit,(±)-Cisaprid,Kinestase

Target: Potassium Channel, 5-HT Receptor, HER

Ensartinib hydrochloride

Cat.No: T22324

Synonym: Ensartinib dihydrochloride,X-396 dihydrochloride

Target: Others, Trk receptor, c-Met/HGFR, ALK

EGFR-IN-1 hydrochloride

Cat.No: T11157L

Target: EGFR

Cat.No: T0242

Synonym: 西他列汀,MK0431,西格列汀

Target: Proteasome, DPP-4, Autophagy

Cat.No: T50077

Synonym: 3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Target: Others

CB2R/FAAH modulator-1

Cat.No: T67896

Target: Cannabinoid Receptor, FAAH

Cat.No: T1024

Synonym: 罗氟司特,B9302-107,BYK 20869,APTA 2217,BY 217

Target: PDE, RSV

Cat.No: T8970

Target: Ferroptosis, GPX, Glutathione Peroxidase

Cat.No: T6611

Synonym: 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran

Target: E1/E2/E3 Enzyme

Cat.No: T16345

Synonym: N-(4-chlorophenyl)-2-(3,5-dimethylpyrazol-1-yl)-9-methylpurin-6-amine,N-(4-Chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine

Target: Potassium Channel

PKUMDL-LC-101-D04

Cat.No: T36935

Synonym: GPX4-Activator-1d4,PKUMDL-LC-101-D04

Target: GPX

Cat.No: T26132

Synonym: RS-14203,RS14203

Besigliptin Tosylate

Cat.No: T26777

Synonym: SHR 117887,SHR-117887,SHR117887

Cat.No: T28520

Synonym: SP-2086,SP2086,SP 2086

Cat.No: T15163

Synonym: DPH-153893

Target: Others

Cat.No: T26857

4-Chloroloratadine

Cat.No: T20815

Synonym: 4-Chloro loratadine,Loratadine specified impurity C

Cat.No: T26941

Synonym: RO-4876904-001,R1579,RG1579,RO-4876904,R-1579,RG-1579

GLUT4 activator 1

Cat.No: T11420

Target: Others

Cat.No: T11499

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1686	Ginsenoside Rg4 人参皂苷 RG4	Antibacterial	Microbiology/Virology
	Ginsenoside Rg4 是分离自Panax ginsengC. A. Meyer 叶子中的一种人参三醇型人参皂苷。人参三醇型人参皂苷具有多种生物活性，包括防腐，抗糖尿病，伤口愈合，免疫刺激和抗氧化活性等。
T4S0792	Pinoresinol 4-O-β-D-glucopyranoside (+)-pinor,(+)-pinoresinol-β-D-glucoside; (+)-pinor,(+)-pinoresinol-β-D-glucoside	Others	Others
	(+)-pinoresinol-β-D-glucoside; (+)-pinor 是连翘中主要的活性呋喃类木脂素。它显示出抗氧化、降血压和环磷酸腺苷 (cAMP) 磷酸二酯酶抑制活性。
TN1418	Azaleatin 杜鹃黄素,2-(3,4-二羟基苯基)-3,7-二羟基-5-甲氧基苯并吡喃-4-酮	DPP-4	Proteases/Proteasome
	Azaleatin 是分离自Rhododendron 种中的 O-甲基化黄酮醇。它是二肽基肽酶-IV 的抑制剂。它在 2 型糖尿病和肥胖症中有研究的价值。
T7132	(Rac)-Brassinazole BRASSINAZOLE,3-(4-氯苯基)-1-甲基-1-苯基-2-(1,2,4-三唑-1-基)-1-丙醇,(Rac)-芸苔素唑	P450	Metabolism
	(Rac)-Brassinazole 是三唑型化合物，是油菜素甾醇 (BR) 生物合成抑制剂。它能够增强 CYP90B 在 BR 生物合成中的抑制作用。
T10024	1-Octanol Octanol,正辛醇	Calcium Channel; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism
	1-Octanol (Octanol) 是一种饱和脂肪醇，是一种 T 型钙通道抑制剂，对天然 T 电流的IC50为 4 μM。它是一种具有类似柴油特性的极具吸引力的生物燃料。
T2862	Desaminotyrosine Phloretate,3-(4-Hydroxyphenyl)propanoic acid,Hydro-p-coumaric acid,对羟基苯丙酸,3-(4-Hydroxyphenyl)propionic acid,Phloretic acid,根皮酸	Others; Influenza Virus; Endogenous Metabolite	Metabolism; Microbiology/Virology; Others
	Desaminotyrosine (3-(4-Hydroxyphenyl)propionic acid) 是一种与微生物相关的代谢物，通过增强 I 型干扰素信号传导来预防流感。
T16442	PCO371 2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	PCO371 (2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-) 是口服具有活性的甲状旁腺激素受体 1 的完全激动剂，对 PTHR2 无作用
T8787	Drotaverine hydrochloride	PDE	Metabolism
	Drotaverine hydrochloride 是磷酸二酯酶 4 (PDE4)的抑制剂，也是 L 型电压依赖钙通道(L-VDCC)的阻滞剂，可阻断3',5'-环腺苷单磷酸的降解。它在体内有抗痉挛效果，但无抗胆碱能的效果。
TN1132	Procyanidin A2 原花青素 A2,原花青素A2	IL Receptor; TNF; transporter; Antibacterial	Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology
	Procyanidin A2 是一种具有抗癌、抗氧化、抗菌和抗炎活性的黄酮类天然产物，存在于蔓越莓和越橘中。
TN1088	3,5,6,7,8,3',4'-Heptemthoxyflavone 3,3',4',5,6,7,8-heptamethoxyflavone,3,5,6,7,8,3',4'-七甲氧基黄酮	Others	Others
	3,5,6,7,8,3',4'-Heptemthoxyflavone 是来自蜜柑皮中的黄酮，具有抗肿瘤起始活性和抗神经炎症作用。它能通过 cAMP/ERK/CREB 信号诱导脑源性神经营养因子表达，降低 C6 细胞磷酸二酯酶活性。它能抑制胶原酶的活性，增加人真皮成纤维细胞新生细胞中 I 型前胶原含量。
T3829	Ginsenoside F3 人参皂苷F3	Others; IFNAR; Interleukin	Immunology/Inflammation; Others
	Ginsenoside F3 是一种皂苷，提取自Panax ginseng 叶片。它能够调节1 型 (IL-2, IFN-γ) 及 2 型细胞因子(IL-4 and IL-10) 的产生和表达，有免疫增强的作用。
TN1936	Mogroside III-E 罗汉果皂苷ⅢE	IL Receptor; TNF; TLR	Apoptosis; Immunology/Inflammation
	Mogroside IIIe 是一种葫芦烷型化合物，从罗汉果中分离得到，可抑制 NO 的释放，具有抗肺纤维化作用。
T2S1792	Lycobetaine 石蒜内胺,Ungeremine,石蒜醋胺,石蒜碱内铵盐	Antibacterial	Microbiology/Virology
	Lycobetaine (Ungeremine) 是一种潜在的抗罗克福尔青霉和黑曲霉的生物杀菌剂。它对柱状黄杆菌有很强的抗菌活性。它有效地靶向哺乳动物以及细菌I 型和II 型拓扑异构酶。它显示出强烈的乙酰胆碱酯酶抑制活性（IC(50) 值为 0.35 microM）。它具有抗原生动物活性，在体外试验中对Trypanosoma brucei rhodesiense、T. cruzi 表现出良好的活性。
T4858	4-Hydroxyphenylpyruvic acid 4-羟苯基丙酮酸,4-Hydroxyphenylpyruvic acid	Endogenous Metabolite	Metabolism
	4-Hydroxyphenylpyruvic acid 是一种苯丙氨酸代谢的中间产物，是一种酶抑制剂。
T4716	Pyrrole-2-carboxylic acid 吡咯-2-羧酸,2-Pyrrolecarboxylic acid,Minaline	Endogenous Metabolite	Metabolism
	Pyrrole-2-carboxylic acid (Minaline) 是一种天然生物碱类，从海洋细菌Pelomonas puraquaesp. Nov 中分离得到。
T6S1699	Shogaol [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol	Lipoxygenase; Autophagy	Autophagy; Metabolism
	6-Shogaol (6-Shogaol) 是从生姜中分离的一种天然产物，具有抗癌、抗炎和抗氧化的多种生物活性。
T3S1612	kuwanon G 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G	Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂，具有杀菌作用。
T2S1865	Octyl gallate Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯	Antioxidant; Influenza Virus; Reactive Oxygen Species; Antibacterial; Antifungal; HSV	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; oxidation-reduction
	Octyl gallate (Octyl 3,4,5-trihydroxybenzoate) 具有抗菌、抗氧化作用，有选择性和敏感性的荧光特性，广泛用作食品添加剂。它对 HSV-1，水泡性口炎病毒和脊髓灰质炎病毒有显著的抗病毒作用。
T11509	Guanfu base H Atisinium chloride	Others	Others
	Guanfu base H is a diterpenoid alkaloid isolated from Aconitum coreanum. It has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 (IC50s: 4 μM and 3.6 μM).
T83593	(+)-trans-3'-Acetyl-4'-isobutyrylkhellactone
	(+)-trans-3'-Acetyl-4'-isobutyrylkhellactone，这种角型吡喃香豆素类化合物是从Peucedani Radix中分离出的一种天然产物。
TN2553	1-Methyl-2-undecyl-4(1H)-quinolone 1-Methyl-2-undecylquinolin-4(1H)-one	MAO	Metabolism; Neuroscience
	1-Methyl-2-undecyl-4(1H)-quinolone, and dihydroevocarpine should also be served as the chemical markers together with evodiamine for the quality control of Evodia rutaecarpa (Juss.) Benth. 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of type B MAO (MAO-B) activity with the IC(50) value of 15.3 microM using a substrate kynuramine, but does not inhibit type A MAO (MAO-A) activity.It can mitigate high phosphate-induced human aortic valve interstitial cells (HAVICs) calcification ...
T4700	1,3,5-Trihydroxy-4-prenylxanthone
	1,3,5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM; it shows in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 valu
T36845	Isogarcinol
	Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 μM) and suppressing the proliferation of T cells. Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental auto...
T73717	cGAMP diammonium
	cGAMP (Cyclic GMP-AMPP) diammonium 是一种内源性第二信使，通过触发干扰素的产生来响应胞浆 DNA。它通过激活干扰素基因刺激因子（STING），启动信号级联，进而导致I型干扰素及其他免疫介质的生成。
T36563	(E)-Guggulsterone
	Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hy...
T35577	Phosphatidylserines (bovine)
	Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on the inner leaflet of the cell membrane. It is biosynthesized from phosphatidylcholine or phosphatidylethanolamine by phosphatidyl synthase 1 (PSS1) or PSS2, respectively, in the endoplasmic reticulum and can be reversibly converted back by the same enzymes. It can also be irreversi...
T37452	Stephacidin B
	Stephacidin B is a fungal metabolite that has been found inA. ochraceus.1Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide ,in vitro.2Stephacidin B is cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC50s = 0.37 and 0.06 μM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC50s = 0.32 and 0.27 μM, respectively).1It induces apoptosis in HepG2 and Huh7 hepatoc...
T35779	Oosporein
	Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ...

天然产物

Ginsenoside Rg4

Cat.No: TN1686

Synonym: 人参皂苷 RG4

Target: Antibacterial

Pinoresinol 4-O-β-D-glucopyranoside

Cat.No: T4S0792

Synonym: (+)-pinor,(+)-pinoresinol-β-D-glucoside; (+)-pinor,(+)-pinoresinol-β-D-glucoside

Target: Others

Cat.No: TN1418

Synonym: 杜鹃黄素,2-(3,4-二羟基苯基)-3,7-二羟基-5-甲氧基苯并吡喃-4-酮

Target: DPP-4

(Rac)-Brassinazole

Cat.No: T7132

Synonym: BRASSINAZOLE,3-(4-氯苯基)-1-甲基-1-苯基-2-(1,2,4-三唑-1-基)-1-丙醇,(Rac)-芸苔素唑

Target: P450

Cat.No: T10024

Synonym: Octanol,正辛醇

Target: Calcium Channel, Endogenous Metabolite

Desaminotyrosine

Cat.No: T2862

Synonym: Phloretate,3-(4-Hydroxyphenyl)propanoic acid,Hydro-p-coumaric acid,对羟基苯丙酸,3-(4-Hydroxyphenyl)propionic acid,Phloretic acid,根皮酸

Target: Others, Influenza Virus, Endogenous Metabolite

Cat.No: T16442

Synonym: 2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-

Target: Thyroid hormone receptor(THR)

Drotaverine hydrochloride

Cat.No: T8787

Target: PDE

Cat.No: TN1132

Synonym: 原花青素 A2,原花青素A2

Target: IL Receptor, TNF, transporter, Antibacterial

3,5,6,7,8,3',4'-Heptemthoxyflavone

Cat.No: TN1088

Synonym: 3,3',4',5,6,7,8-heptamethoxyflavone,3,5,6,7,8,3',4'-七甲氧基黄酮

Target: Others

Cat.No: T3829

Synonym: 人参皂苷F3

Target: Others, IFNAR, Interleukin

Mogroside III-E

Cat.No: TN1936

Synonym: 罗汉果皂苷ⅢE

Target: IL Receptor, TNF, TLR

Cat.No: T2S1792

Synonym: 石蒜内胺,Ungeremine,石蒜醋胺,石蒜碱内铵盐

Target: Antibacterial

4-Hydroxyphenylpyruvic acid

Cat.No: T4858

Synonym: 4-羟苯基丙酮酸,4-Hydroxyphenylpyruvic acid

Target: Endogenous Metabolite

Pyrrole-2-carboxylic acid

Cat.No: T4716

Synonym: 吡咯-2-羧酸,2-Pyrrolecarboxylic acid,Minaline

Target: Endogenous Metabolite

Cat.No: T6S1699

Synonym: [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol

Target: Lipoxygenase, Autophagy

Cat.No: T3S1612

Synonym: 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G

Target: Phosphatase, Antibacterial, Bombesin Receptor, AChR, AChE, Glucosidase

Cat.No: T2S1865

Synonym: Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯

Target: Antioxidant, Influenza Virus, Reactive Oxygen Species, Antibacterial, Antifungal, HSV

Cat.No: T11509

Synonym: Atisinium chloride

Target: Others

(+)-trans-3'-Acetyl-4'-isobutyrylkhellactone

Cat.No: T83593

1-Methyl-2-undecyl-4(1H)-quinolone

Cat.No: TN2553

Synonym: 1-Methyl-2-undecylquinolin-4(1H)-one

Target: MAO

1,3,5-Trihydroxy-4-prenylxanthone

Cat.No: T4700

Cat.No: T36845

cGAMP diammonium

Cat.No: T73717

(E)-Guggulsterone

Cat.No: T36563

Phosphatidylserines (bovine)

Cat.No: T35577

Cat.No: T37452

Cat.No: T35779

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