Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage and NF-κB signaling, further contributing to its antitumor activity.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 183 | 现货 | ||
5 mg | ¥ 397 | 现货 | ||
10 mg | ¥ 663 | 现货 | ||
25 mg | ¥ 1,150 | 现货 | ||
50 mg | ¥ 1,680 | 现货 | ||
100 mg | ¥ 2,530 | 现货 | ||
500 mg | ¥ 5,950 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 421 | 现货 |
产品描述 | NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage and NF-κB signaling, further contributing to its antitumor activity. |
体外活性 | NSC697923 (0-5 μM; 24 hours) shows cytotoxic effect on NB cell lines. NSC697923 (3 μM; 2 hours) can also induce apoptosis in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 induces apoptosis in p53 wild-type NB cell lines by promoting p53 nuclear translocation and activation[1]. |
体内活性 | NSC697923 (5 mg/kg; i.p.; daily for 10 days) suppresses NB tumor growth in SH-SY5Y and NGP xenografts[1]. |
别名 | 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran |
分子量 | 267.26 |
分子式 | C11H9NO5S |
CAS No. | 343351-67-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 6.7 mg/mL (25 mM)), Heating is recommended.
DMSO: 180 mg/mL (673.5 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / DMSO | 1 mM | 3.7417 mL | 18.7084 mL | 37.4167 mL | 93.5419 mL |
5 mM | 0.7483 mL | 3.7417 mL | 7.4833 mL | 18.7084 mL | |
10 mM | 0.3742 mL | 1.8708 mL | 3.7417 mL | 9.3542 mL | |
20 mM | 0.1871 mL | 0.9354 mL | 1.8708 mL | 4.6771 mL | |
DMSO | 50 mM | 0.0748 mL | 0.3742 mL | 0.7483 mL | 1.8708 mL |
100 mM | 0.0374 mL | 0.1871 mL | 0.3742 mL | 0.9354 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
NSC697923 343351-67-7 Ubiquitination E1/E2/E3 Enzyme NSC 697923 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran NSC-697923 Inhibitor inhibitor inhibit