Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gemigliptin Tartrate (LC15-0444 tartrate) 是一种选择性的,可逆的,竞争性的二肽基肽酶 4 (DPP-4) 抑制剂,对于人重组 DPP-4 的IC50=10.3 nM。Gemigliptin tartrate 具有很强的抗糖基化活性,能够用于晚期糖基化终产物相关的糖尿病并发症的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 245 | 现货 | ||
2 mg | ¥ 349 | 现货 | ||
5 mg | ¥ 568 | 现货 | ||
10 mg | ¥ 913 | 现货 | ||
25 mg | ¥ 1,650 | 现货 | ||
50 mg | ¥ 2,730 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 983 | 现货 |
产品描述 | Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4). It has an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate exhibits potent anti-glycation properties. |
靶点活性 | DPP4 (human recombinant):10.3 nM |
体外活性 | Gemigliptin tartrate inhibits the formation of AGE-BSA with IC50 of 11.69 mM[1]. Gemigliptin tartrate suppresses the cross-linking of preformed AGE-BSA with rat tail tendon collagen with an IC50 of 1.39 mM[1]. Gemigliptin tartrate is a competitive DPP-4 inhibitor with a Ki of 7.25 nM[2]. |
体内活性 | Gemigliptin tartrate inhibits AGEs formation and AGE cross-links in vivo[1]. Gemigliptin tartrate dose-dependently inhibits plasma DPP-4 activity in rats, dogs, and monkeys[2]. |
别名 | 吉格列汀酒石酸盐, LC15-0444 tartrate |
分子量 | 639.45 |
分子式 | C22H25F8N5O8 |
CAS No. | 1374639-74-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL(140.75 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.5638 mL | 7.8192 mL | 15.6384 mL | 39.0961 mL |
5 mM | 0.3128 mL | 1.5638 mL | 3.1277 mL | 7.8192 mL | |
10 mM | 0.1564 mL | 0.7819 mL | 1.5638 mL | 3.9096 mL | |
20 mM | 0.0782 mL | 0.391 mL | 0.7819 mL | 1.9548 mL | |
50 mM | 0.0313 mL | 0.1564 mL | 0.3128 mL | 0.7819 mL | |
100 mM | 0.0156 mL | 0.0782 mL | 0.1564 mL | 0.391 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Gemigliptin Tartrate(911637-19-9 free base) 1374639-74-3 Proteases/Proteasome Ubiquitination Proteasome DPP-4 type Gemigliptin products mellitus peptidase-4 Gemigliptin Tartrate(911637 19 9 free base) dipeptidyl Gemigliptin Tartrate(911637199 free base) advanced diabetes Inhibitor 吉格列汀酒石酸盐 LC15-0444 tartrate LC15-0444 Tartrate end glycation DPP Dipeptidyl Peptidase LC15-0444 AGE inhibit inhibitor