Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ensartinib hydrochloride (X-396 dihydrochloride) 是双重的 ALK/MET 抑制剂,IC50分别 <0.4 nM 和 0.74 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 496 | 现货 | ||
2 mg | ¥ 733 | 现货 | ||
5 mg | ¥ 1,230 | 现货 | ||
10 mg | ¥ 1,990 | 现货 | ||
25 mg | ¥ 3,970 | 现货 | ||
50 mg | ¥ 5,850 | 现货 | ||
100 mg | ¥ 8,120 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,730 | 现货 |
产品描述 | Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK mutations. It potently inhibits both wild-type ALK and ALK variants (C1156Y, F1174, G1202R, L1196M, S1206R, and T1151 mutants) with in vitro IC50s of <4 nM. |
靶点活性 | TPM3-TRKA:<1 nM, TrkC:<1 nM, ALK:<4 nM, ALK (variants):<4 nM, GOPC-ROS1:<1 nM |
体外活性 | Ensartinib potently inhibits both wild-type ALK and all evaluated ALK variants (C1156Y, F1174, G1202R, L1196M, S1206R, and T1151 mutants) with in vitro IC50s of <4 nM. Besides ALK, ensartinib also potently inhibits GOPC-ROS1, TPM3-TRKA, and TRKC with an IC50 of <1 nM, and inhibits EphA1, EphA2, EphB1 and c-MET with an IC50 of 1-10 nM[1]. |
别名 | Ensartinib dihydrochloride, X-396 dihydrochloride |
分子量 | 634.36 |
分子式 | C26H29Cl4FN6O3 |
CAS No. | 2137030-98-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33mg/ml (52.02 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.5764 mL | 7.882 mL | 15.7639 mL | 39.4098 mL |
5 mM | 0.3153 mL | 1.5764 mL | 3.1528 mL | 7.882 mL | |
10 mM | 0.1576 mL | 0.7882 mL | 1.5764 mL | 3.941 mL | |
20 mM | 0.0788 mL | 0.3941 mL | 0.7882 mL | 1.9705 mL | |
50 mM | 0.0315 mL | 0.1576 mL | 0.3153 mL | 0.7882 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ensartinib hydrochloride 2137030-98-7 Angiogenesis Others Tyrosine Kinase/Adaptors Trk receptor c-Met/HGFR ALK X 396 X396 Cluster of differentiation 246 Ensartinib Ensartinib dihydrochloride Inhibitor CD246 X-396 Ensartinib Hydrochloride Anaplastic lymphoma kinase (ALK) Anaplastic lymphoma kinase X-396 dihydrochloride ALK tyrosine kinase receptor X-396 Dihydrochloride X396 Dihydrochloride inhibit X 396 Dihydrochloride Ensartinib Dihydrochloride inhibitor