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Search Results for " obr "

Targets Recommended: Others

151

抑制剂 & 化合物

22

天然产物

9

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TD0105	Sulfobromophthalein disodium salt	Others	Others
	Sulfobromophthalein disodium salt 是一种有机阴离子染料，能够参与药物和代谢物的运输，可用于研究动物组织中表达的多种膜载体。
T40363	Poly-D-lysine hydrobromide (MW 30000-70000) Poly-D-lysine HBr (MW 30000-70000)	CaSR	GPCR/G Protein
	Poly-D-lysine hydrobromide (MW 30000-70000)(Poly-D-lysine HBr) 是一种可口服的肽类 CaSR 激动剂，可从朊病毒感染的 SN56 神经母细胞瘤细胞中去除蛋白酶 K 抗性的 PrP。
T6133	Remodelin hydrobromide Remodelin,Remodelin HBR	RAAS; Histone Acetyltransferase	Chromatin/Epigenetic; Endocrinology/Hormones
	Remodelin hydrobromide (Remodelin HBR) 是一种新型有效的选择性乙酰转移酶蛋白 NAT10 抑制剂，能改善早衰综合征细胞表型。
T3156	Ciliobrevin A Hedgehog Pathway Inhibitor 4,HPI-4	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	Ciliobrevin A (HPI-4) 是Hedgehog(Hh) 信号通路抑制剂，平均抑制浓度 (IC50) 值小于 10 μM。
T21788	BD 1008 dihydrobromide	Sigma receptor	GPCR/G Protein
	BD 1008 dihydrobromide 是 sigma 1 (σ1) 受体 (Ki = 2 nM) 的选择性拮抗剂。它对 sigma1 受体具有高亲和力，对 sigma2 受体具有中等亲和力。它通过拮抗 σ 受体减弱可卡因的毒性和刺激作用。
T4570	Pipobroman Vercyte,A-8103,Amedel,哌泊溴烷	Others; DNA Alkylator/Crosslinker	DNA Damage/DNA Repair; Others
	Pipobroman (Vercyte) 是一种烷基化剂，是哌嗪的溴化衍生物。它通过抑制 DNA 和 RNA 聚合酶或减少嘧啶核苷酸掺入 DNA 发挥其作用。它在真性红细胞增多症和原发性血小板增多症中具有良好的临床活性，可用于癌症研究。
T13110	Tedatioxetine hydrobromide Lu AA 24530 hydrobromide	Dopamine Receptor; 5-HT Receptor; Norepinephrine	GPCR/G Protein; Neuroscience
	Tedatioxetine hydrobromide (Lu AA 24530 hydrobromide) 是一种血清素-去甲肾上腺素-多巴胺再摄取抑制剂，也是 5-HT2A、5-HT2C、5-HT3 和 α1A-肾上腺素能受体的拮抗剂，可用于治疗抑郁症和焦虑症。
T1740	BD-1047 dihydrobromide BD1047.2HBr	Sigma receptor	GPCR/G Protein
	BD-1047 dihydrobromide (BD1047.2HBr) 是一种选择性的 sigma-1 receptor 受体拮抗剂，在预测精神分裂症疗效的动物模型中具有抗精神病活性。
T2395L	Vortioxetine hydrobromide 氢溴酸沃替西汀,Vortioxetine (Lu AA21004) HBr,Vortioxetine HBr,盐酸沃替西汀,Lu AA21004 hydrobromide	5-HT Receptor; Serotonin Transporter	GPCR/G Protein; Neuroscience
	Vortioxetine hydrobromide (Lu AA21004 hydrobromide) 是5-HT1A、5-HT1B、5-HT3A、5-HT7受体和5-羟色胺转运体(SERT)的抑制剂，Ki 值分别为 15、33、3.7、19 和 1.6 nM。
T61151	Beclobrate
	Beclobrate (Sgd 24774), a fibric acid derivative, exhibits potent lipid-lowering efficacy in rodent models [1].
T5351L	PU-WS13 hydrobromide PU-WS13 hydrobromide (1454619-14-7 Free base)	GPR	Endocrinology/Hormones; GPCR/G Protein
	PU-WS13 hydrobromide 是一种 GRP94 抑制剂，具有抗炎活性，对小鼠 TNBC 肿瘤中的 M2 样巨噬细胞的增殖具有抑制作用。
T10813	Cilobradine hydrochloride DK-AH 269	HCN Channel	Membrane transporter/Ion channel
	Cilobradine hydrochloride (DK-AH 269) 是一种 HCN 通道阻断剂。
T77795	L-DABA hydrobromide L-2,4-Diaminobutyric acid hydrobromide	Others; Endogenous Metabolite	Metabolism; Others
	L-DABA hydrobromide (L-2,4-Diaminobutyric acid hydrobromide) 是一种有效的 GABA 转氨酶抑制剂，具有抗肿瘤和抗惊厥活性，可用于研究神经系统疾病。
T6832	Fatostatin hydrobromide Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin	NPC1L1; Fatty Acid Synthase	Membrane transporter/Ion channel; Metabolism
	Fatostatin hydrobromide (Fatostatin A HBr) 是一种 SREBP 活化的特异性抑制剂，可抑制 SREBP-1 和 SREBP-2 的活化。它与 SCAP (SREBP 裂解激活蛋白) 结合，抑制 SREBPs 的 ER-Golgi 易位。它具有抗肿瘤作用，能抑制 ob/ob 小鼠的高血糖。它抑制了细胞中成脂基因的转录。
T3637	Pifithrin-β hydrobromide Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)	Ferroptosis; p53	Apoptosis
	Pifithrin-β hydrobromide (Cyclic PFT-α) 是一种 p53 的抑制剂，可逆地阻断 p53 依赖性转录激活和细胞凋亡。IC50值为23 μM。
T10104	3,4-Dihydroxybenzylamine hydrobromide NSC 263475 hydrobromide,3,4-二羟基苄胺·氢溴酸	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	3,4-Dihydroxybenzylamine hydrobromide (NSC-263475 hydrobromide) 抑制黑色素瘤细胞中的 DNA 聚合酶活性，并在具有不同程度酪氨酸酶活性的黑色素瘤细胞系中显示出生长抑制活性。
T7208	AMD 3465 hexahydrobromide GENZ-644494 (hexahydrobromide)	HIV Protease; CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) 是一种 CXCR4受体拮抗剂，具有潜在的抗癌和抗 HIV 活性。
T1534	Darifenacin hydrobromide 氢溴酸达非那新,Darifenacin HBr,UK-88525	AChR	Neuroscience
	Darifenacin hydrobromide (UK-88525) 是一种选择性 M3 蕈毒碱受体拮抗剂，pKi 为 8.9。
T22864	Immethridine dihydrobromide	Others	Others
	Immethridine dihydrobromide is a histamine H3 receptor agonist.
T36287	Pirtobrutinib	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	Pirtobrutinib (LOXO-305) is an advanced BTK inhibitor that displays high selectivity and operates through a non-covalent mechanism. This compound effectively inhibits various BTK C481 substitution mutations, leading to tumor regression in BTK-dependent lymphoma tumors in mouse xenograft models. Furthermore, Pirtobrutinib exhibits remarkable selectivity for BTK, with more than a 300-fold difference compared to 370 other kinases tested. Notably, at a concentration of 1 μM, Pirtobrutinib demonstrat...
T8495	Alobresib Vorolanib,GS-5829	Epigenetic Reader Domain	Chromatin/Epigenetic
	Alobresib (Vorolanib) 是一种BET 溴结构域抑制剂，是一种抗肿瘤候选药物。
T0216	Eletriptan hydrobromide Eletriptan HBr,UK-116044,依来曲普坦氢溴酸盐	5-HT Receptor	GPCR/G Protein; Neuroscience
	Eletriptan hydrobromide (Eletriptan HBr) 是一种口服活性激动剂，对 5-HT1B/1D 受体具有特异性亲和力，Ki 值分别为 0.92 和 3.14 nM。
T6999	Teneligliptin hydrobromide Teneligliptin hydrobromide anhydrous,MP-513 (hydrobromide)	Others; Proteasome; DPP-4	Others; Proteases/Proteasome; Ubiquitination
	Teneligliptin hydrobromide (MP-513(hydrobromide)) 是β2肾上腺素能受体 (β2AR) 阻滞剂，具有抗高血压、抗氧化、清除自由基的活性。
T1483	Citalopram hydrobromide Lu 10-171,Nitalapram HBr,Bonitrile HBr,XU-62-320,Lu 10-171 HBr,氢溴酸西酞普兰,Citalopram HBr	5-HT Receptor; Serotonin Transporter; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Citalopram hydrobromide (XU-62-320) 是一种选择性 5-羟色胺再摄取抑制剂，可选择性地抑制 CNS 神经元对 5-羟色胺的再摄取，从而增强中枢神经系统中的 5-羟色胺能活性，也具有抗抑郁活性。它抑制兔血小板中 5-HT 的摄取，IC50为 14 nM。
T4387	evobrutinib MSC2364447C,M2951	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	Evobrutinib(M2951) 也称为 M-2951 和 MSC-2364447C，是布鲁顿酪氨酸激酶(BTK) 的高选择性抑制剂，BTK 对包括 B 淋巴细胞和巨噬细胞在内的各种免疫细胞的发育和功能很重要。临床前研究表明它可能对某些自身免疫性疾病有治疗作用。
T14965	Ciliobrevin D	ATPase; Hedgehog/Smoothened	GPCR/G Protein; Membrane transporter/Ion channel; Stem Cells
	Ciliobrevin D 是细胞渗透性，可逆和特异性的 AAA + ATPase 运动细胞质动力蛋白抑制剂。它在体外抑制依赖于动力蛋白的微管滑动和 ATPase 活性。它抑制Hedgehog 信号和初级纤毛形成。
T17002	Tazemetostat hydrobromide E-7438 hydrobromide,氢溴酸泰泽司他,EPZ-6438 hydrobromide	Histone Methyltransferase	Chromatin/Epigenetic
	Tazemetostat hydrobromide (E-7438 hydrobromide) 是口服的EZH2选择性抑制剂。它抑制含有 PRC2 复合体的野生型 EZH2 的活性，Ki 为 2.5 nM。它还抑制 EZH1，IC50为 392 nM。
T22534	8-Hydroxy-DPAT hydrobromide 7-(二丙基氨基)-5,6,7,8-四氢-1-萘酚氢溴酸盐,8-OH-DPAT hydrobromide	5-HT Receptor	GPCR/G Protein; Neuroscience
	8-Hydroxy-DPAT hydrobromide (8-OH-DPAT hydrobromide) 是一种选择性5-HT1A 激动剂，pIC50为 8.19。它对 5-HT1结合位点的亚型有近 1000 倍的选择性。
T22761	EIT hydrobromide 2-Ethyl-2-thiopseudourea hydrobromide,S-Ethylisothiourea hydrobromide,S-乙基硫酸乙烯溴化氢	NOS	Immunology/Inflammation
	EIT hydrobromide (S-Ethylisothiourea hydrobromide) 是一种iNOS 抑制剂。
T2707	Pifithrin-α hydrobromide Pifithrin hydrobromide,Pifithrin-α (PFTα) HBr,Pifithrin-α,PFTα,PFTα hydrobromide	Ferroptosis; Aryl Hydrocarbon Receptor; p53	Apoptosis; Immunology/Inflammation
	Pifithrin-α hydrobromide (Pifithrin-α hydrobromide) 是一种 p53 抑制剂，可抑制 p53 反应基因的 p53 依赖性反式激活。它也是芳烃受体的激动剂。
T7543	S-(2-aminoethyl) Isothiourea (dihydrobromide)	NOS	Immunology/Inflammation
	S-(2-aminoethyl) Isothiourea (dihydrobromide) 是所有 NOS 异构体的非选择性抑制剂。对于人类 nNOS、eNOS 和 iNOS，Ki 值分别为 1.8、2.1 和 0.59 µM。
T7206L	2-Iminobiotin hydrobromide 2-亚氨基生物素,Guanidinobiotin,2-亚氨基生物素盐酸盐	NOS; NO Synthase	Immunology/Inflammation
	2-Iminobiotin hydrobromide (Guanidinobiotin) 是生物素 (维生素 H 或 B7) 类似物。它是一种可逆的 NO 合酶抑制剂，可作用于小鼠 iNOS(Ki:21.8 μM)和大鼠 n-cNOS(Ki:37.5 μM)。它和低温环境均可以保护人类神经细胞，使其免受缺氧诱导的细胞损伤。
T21685	CCT 031374 hydrobromide	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	CCT 031374 hydrobromide 是一种 TCF/β-catenin 抑制剂，具有抗肿瘤活性。
T10717	Inobrodib CBP-IN-1	Epigenetic Reader Domain	Chromatin/Epigenetic
	Inobrodib (CBP-IN-1) 是一种口服活性的强选择性p300/CBP 抑制剂，与 p300 和 CBP 结合，Kd 值为 1.3 和 1.7 nM。它抑制前列腺癌细胞系的细胞增殖并降低雄激素受体和 C-MYC 调节的基因表达。
T12352L	Oxidopamine hydrobromide 6-Hydroxydopamine hydrobromide,6-羟基多巴胺氢溴酸盐,6-OHDA hydrobromide	Mitophagy; Dopamine Receptor; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Oxidopamine hydrobromide (6-OHDA hydrobromide) 是一种神经递质多巴胺拮抗剂，可选择性地破坏多巴胺能神经元，是一种广泛使用的神经毒素。
T8439	Clobenpropit dihydrobromide	Apoptosis; Histamine Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Clobenpropit dihydrobromide 是一种组胺H3R 拮抗剂/反向激动剂。它与 5-HT3 受体和 α2A/α2C 肾上腺素受体结合，对组胺H4受体起部分激动剂的作用，还能促进凋亡。
T78410	Gly-Pro-AMC hydrobromide Gly-Pro-AMC HCl
	Gly-Pro-AMC hydrobromide (Gly-Pro-AMC HCl) 为特异性荧光染料，用于细胞荧光检测，检测 Dipeptidyl peptidase IV (DPP-IV) 活性。
T5956	VP3.15 dihydrobromide	GSK-3; PDE	Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	VP3.15 dihydrobromide 是一种口服具有活力的、高效的、CNS 可渗透的PDE7-GSK3双重抑制剂，对 PDE7 和 GSK3 作用的IC50值分别为 1.59 μM 和 0.88 μM。它具有神经保护和神经修复作用，可用于研究多发性硬化症 (MS) 潜在的抗炎和促髓鞘再生联合。
T12172	NAN-190 hydrobromide	5-HT Receptor	GPCR/G Protein; Neuroscience
	NAN-190 hydrobromide 是一种5-HT1A 选择性拮抗剂。
T70260	AMD-3329 hydrobromide
	AMD-3329 hydrobromide is a biochemical in the class of potent and selective anti-HIV-1 and HIV-2 agents that inhibit virus replication by binding to the chemokine receptor CXCR4, the co-receptor for entry of X4 viruses.
T24035	Eptazocine hydrobromide MCV 4169,ST-2121,MCV-4169,sT 2121, l-,l-ST-2121
	Eptazocine hydrobromide is an agonist of the Opioid receptor and is a kappa-Opioid receptor agonist. It is also an Opioid analgesic and an Opioid receptor antagonist.
T69519	Iroxanadine hydrobromide
	Iroxanadine hydrobromide is a MAPK p38 inhibitor potentially for the treatment of atherosclerosis.
T71496	Isoremoxipride hydrobromide
	Isoremoxipride hydrobromide is a dopamine antagonist.
T15565	Imetit dihydrobromide VUF 8325 dihydrobromide,SKF 91105 dihydrobromide	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Imetit dihydrobromide is a high affinity and effective agonist of histamine H3 and H4 receptors (Ki: 0.3 and 2.7 nM). Imetit mimics the histamine effect in triggering a shape change in eosinophils (EC50: 25 nM).
T61999	Quinine hydrobromide
	Quinidine hydrobromide 是有效的、选择性的的、具有口服活性的细胞色素 P450db (cytochrome P450db) 抑制剂。Quinidine hydrobromide 是 K+通道 (K+channel) 的有效阻断剂（IC50= 19.9 μM）。Quinidine hydrobromide 具有抗心律失常的作用。Quinidine hydrobromide 也可用作疟疾的研究。
T60530	Mercaptoethylguanidine (MEG) (dihydrobromide)
	Mercaptoethylguanidine (MEG) dihydrobromide 是选择性的诱导型一氧化氮合酶抑制剂和过氧亚硝酸盐清除剂，在炎症性肠病研究中具有潜力。
T77905	Vobramitamab AEX-4089
	Vobramitamab为针对人源B7-H3的单克隆抗体(mAb)。该抗体通过一个可切割的连接物与前药seco-DUBA相结合，构成一种抗体-药物偶联物(ADC)名为MGC018。
T15590	Iodophenpropit dihydrobromide	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Iodophenpropit dihydrobromide is an effective and selective antagonist of the histamine H3 receptor. The binding of [125I]Iodophenpropit is readily reversible, selective, and of high affinity (KD: 0.32 nM).
T38221	N,N-Dipropyldopamine (hydrobromide)
	N,N-Dipropyldopamine is a dopamine receptor agonist.1,2,3 It decreases dihydrophenylalanine (DOPA) levels in the limbic forebrain and striatum of reserpinized rats (ED50s = 25 and 20 μmol/kg, respectively), as well as reduces homovanillic acid levels in rat striatum when administered at a dose of 80 μmol/kg.1 N,N-Dipropyldopamine (0.5-16 mg/kg) reduces spontaneous locomotor activity in mice, an effect that can be reversed by the antipsychotic spiroperidol.2,3
T37150	ADTN hydrobromide
	ADTN hydrobromide (6,7-ADTN) is a dopamine receptor agonist (EC50s = 3.5 and 0.65 μM in rat striatal and nucleus accumbens homogenates, respectively). ADTN hydrobromide stimulates production of cAMP in rat striatal homogenates, a process that is reduced by 70% in the presence of the dopamine antagonist fluphenazine at a concentration of 1 μM.

化合物

Sulfobromophthalein disodium salt

Cat.No: TD0105

Target: Others

Poly-D-lysine hydrobromide (MW 30000-70000)

Cat.No: T40363

Synonym: Poly-D-lysine HBr (MW 30000-70000)

Target: CaSR

Remodelin hydrobromide

Cat.No: T6133

Synonym: Remodelin,Remodelin HBR

Target: RAAS, Histone Acetyltransferase

Cat.No: T3156

Synonym: Hedgehog Pathway Inhibitor 4,HPI-4

Target: Hedgehog/Smoothened

BD 1008 dihydrobromide

Cat.No: T21788

Target: Sigma receptor

Cat.No: T4570

Synonym: Vercyte,A-8103,Amedel,哌泊溴烷

Target: Others, DNA Alkylator/Crosslinker

Tedatioxetine hydrobromide

Cat.No: T13110

Synonym: Lu AA 24530 hydrobromide

Target: Dopamine Receptor, 5-HT Receptor, Norepinephrine

BD-1047 dihydrobromide

Cat.No: T1740

Synonym: BD1047.2HBr

Target: Sigma receptor

Vortioxetine hydrobromide

Cat.No: T2395L

Synonym: 氢溴酸沃替西汀,Vortioxetine (Lu AA21004) HBr,Vortioxetine HBr,盐酸沃替西汀,Lu AA21004 hydrobromide

Target: 5-HT Receptor, Serotonin Transporter

Cat.No: T61151

PU-WS13 hydrobromide

Cat.No: T5351L

Synonym: PU-WS13 hydrobromide (1454619-14-7 Free base)

Target: GPR

Cilobradine hydrochloride

Cat.No: T10813

Synonym: DK-AH 269

Target: HCN Channel

L-DABA hydrobromide

Cat.No: T77795

Synonym: L-2,4-Diaminobutyric acid hydrobromide

Target: Others, Endogenous Metabolite

Fatostatin hydrobromide

Cat.No: T6832

Synonym: Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin

Target: NPC1L1, Fatty Acid Synthase

Pifithrin-β hydrobromide

Cat.No: T3637

Synonym: Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)

Target: Ferroptosis, p53

3,4-Dihydroxybenzylamine hydrobromide

Cat.No: T10104

Synonym: NSC 263475 hydrobromide,3,4-二羟基苄胺·氢溴酸

Target: Others, DNA/RNA Synthesis

AMD 3465 hexahydrobromide

Cat.No: T7208

Synonym: GENZ-644494 (hexahydrobromide)

Target: HIV Protease, CXCR

Darifenacin hydrobromide

Cat.No: T1534

Synonym: 氢溴酸达非那新,Darifenacin HBr,UK-88525

Target: AChR

Immethridine dihydrobromide

Cat.No: T22864

Target: Others

Cat.No: T36287

Target: BTK

Cat.No: T8495

Synonym: Vorolanib,GS-5829

Target: Epigenetic Reader Domain

Eletriptan hydrobromide

Cat.No: T0216

Synonym: Eletriptan HBr,UK-116044,依来曲普坦氢溴酸盐

Target: 5-HT Receptor

Teneligliptin hydrobromide

Cat.No: T6999

Synonym: Teneligliptin hydrobromide anhydrous,MP-513 (hydrobromide)

Target: Others, Proteasome, DPP-4

Citalopram hydrobromide

Cat.No: T1483

Synonym: Lu 10-171,Nitalapram HBr,Bonitrile HBr,XU-62-320,Lu 10-171 HBr,氢溴酸西酞普兰,Citalopram HBr

Target: 5-HT Receptor, Serotonin Transporter, Autophagy

Cat.No: T4387

Synonym: MSC2364447C,M2951

Target: BTK

Cat.No: T14965

Target: ATPase, Hedgehog/Smoothened

Tazemetostat hydrobromide

Cat.No: T17002

Synonym: E-7438 hydrobromide,氢溴酸泰泽司他,EPZ-6438 hydrobromide

Target: Histone Methyltransferase

8-Hydroxy-DPAT hydrobromide

Cat.No: T22534

Synonym: 7-(二丙基氨基)-5,6,7,8-四氢-1-萘酚氢溴酸盐,8-OH-DPAT hydrobromide

Target: 5-HT Receptor

EIT hydrobromide

Cat.No: T22761

Synonym: 2-Ethyl-2-thiopseudourea hydrobromide,S-Ethylisothiourea hydrobromide,S-乙基硫酸乙烯溴化氢

Target: NOS

Pifithrin-α hydrobromide

Cat.No: T2707

Synonym: Pifithrin hydrobromide,Pifithrin-α (PFTα) HBr,Pifithrin-α,PFTα,PFTα hydrobromide

Target: Ferroptosis, Aryl Hydrocarbon Receptor, p53

S-(2-aminoethyl) Isothiourea (dihydrobromide)

Cat.No: T7543

Target: NOS

2-Iminobiotin hydrobromide

Cat.No: T7206L

Synonym: 2-亚氨基生物素,Guanidinobiotin,2-亚氨基生物素盐酸盐

Target: NOS, NO Synthase

CCT 031374 hydrobromide

Cat.No: T21685

Target: Wnt/beta-catenin

Cat.No: T10717

Synonym: CBP-IN-1

Target: Epigenetic Reader Domain

Oxidopamine hydrobromide

Cat.No: T12352L

Synonym: 6-Hydroxydopamine hydrobromide,6-羟基多巴胺氢溴酸盐,6-OHDA hydrobromide

Target: Mitophagy, Dopamine Receptor, Autophagy

Clobenpropit dihydrobromide

Cat.No: T8439

Target: Apoptosis, Histamine Receptor

Gly-Pro-AMC hydrobromide

Cat.No: T78410

Synonym: Gly-Pro-AMC HCl

VP3.15 dihydrobromide

Cat.No: T5956

Target: GSK-3, PDE

NAN-190 hydrobromide

Cat.No: T12172

Target: 5-HT Receptor

AMD-3329 hydrobromide

Cat.No: T70260

Eptazocine hydrobromide

Cat.No: T24035

Synonym: MCV 4169,ST-2121,MCV-4169,sT 2121, l-,l-ST-2121

Iroxanadine hydrobromide

Cat.No: T69519

Isoremoxipride hydrobromide

Cat.No: T71496

Imetit dihydrobromide

Cat.No: T15565

Synonym: VUF 8325 dihydrobromide,SKF 91105 dihydrobromide

Target: Histamine Receptor

Quinine hydrobromide

Cat.No: T61999

Mercaptoethylguanidine (MEG) (dihydrobromide)

Cat.No: T60530

Cat.No: T77905

Synonym: AEX-4089

Iodophenpropit dihydrobromide

Cat.No: T15590

Target: Histamine Receptor

N,N-Dipropyldopamine (hydrobromide)

Cat.No: T38221

ADTN hydrobromide

Cat.No: T37150

Cat. No.	Product Name	Target	Signaling Pathways
T8304	Anisodamine Hydrobromide 6-Hydroxyhyoscyamine,氢溴酸山莨菪碱	Adrenergic Receptor; AChR	GPCR/G Protein; Neuroscience
	Anisodamine Hydrobromide (6-Hydroxyhyoscyamine) 是来自颠茄的一种生物碱，具有抗氧化、抗炎活性。它也是一种非亚型的选择性毒蕈碱和烟碱类胆碱受体拮抗剂。
T0086	Galanthamine hydrobromide Galantamine hydrobromide,Galanthamine HBr,氢溴酸加兰他敏	AChR; AChE	Neuroscience
	Galanthamine hydrobromide (Galantamine hydrobromide) 是一种长效的中枢活性 AChE 抑制剂，IC50为 410 nM。它是神经元烟碱型 ACh 受体的变构增强剂，IC50值为 0.35 µM，可用于阿尔茨海默症的研究。
T6560	Lappaconitine hydrobromide 氢溴酸高乌甲素,Lappaconite HBr,Allapinine	Others	Others
	Lappaconitine hydrobromide (Allapinine) 是天然生物碱类化合物，具有抗心律失常作用。
T1255	Tobramycin NSC 180514,妥布霉素,Nebramycin Factor 6,Deoxykanamycin B	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Tobramycin (NSC-180514) 是一种胃肠外给药的广谱氨基糖苷类抗生素，可研究由于敏感生物引起的中度至重度细菌感染疾病。
T0625	Theobromine 3, 7-Dimethylxanthine,可可碱,3,7-Dimethylxanthine	Endogenous Metabolite; PDE; Adenosine Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Theobromine (3,7-Dimethylxanthine) 是在可可豆中发现的一种甲基黄嘌呤，抑制腺苷受体 A1 信号传导，用作支气管扩张剂和血管扩张剂。
T3524	Halofuginone hydrobromide 卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐	Others; Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Others; Stem Cells
	Halofuginone hydrobromid 是Febrifugine 的衍生物，是竞争性脯氨酰-tRNA 合成酶抑制剂。它是 I 型胶原合成的特异性抑制剂，并通过抑制TGF-β活性可减轻骨关节炎。它具有抗疟疾、抗炎、抗癌、抗纤维化作用。
T41372	(22S,23S)-Homobrassinolide 油菜素内酯,SSHB	Others	Others
	(22S,23S)-Homobrassinolide (SSHB) 在各种植物生物测定试验中均能诱导植物生长。
T2198	Arecoline hydrobromide Arecoline HBr,氢溴酸槟榔碱,Arecoline bromide	AChR	Neuroscience
	Arecoline hydrobromide (Arecoline HBr) 是从槟榔中得到的一种生物碱，具有刺激、警觉、抗焦虑和抗寄生虫作用。它是烟碱和毒蕈碱乙酰胆碱受体的部分激动剂，可诱导氧化应激。
T11041	Dihydro-β-erythroidine hydrobromide DHβE hydrobromide	Others	Others
	Dihydro-β-erythroidine hydrobromide(DHβE) is a potent, oral active and competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs). Dihydro-β-carotene hydrobromide showed selectivity to α4β4 and α4β2nAChR, with IC50 of 0.19 and 0.37 μM,
T75485	Dehydrobruceine B
	Dehydrobruceine B 是一种苦木素，可从鸦胆子 (Brucea javanica) 中分离得到。Dehydrobruceine B 与 Cisplatin 通过线粒体途径，协同诱导细胞凋亡 (apoptosis)。Dehydrobruceine B 还增加凋亡诱导因子 (AIF) 和 Bax 表达，抑制 Keap1-Nrf2。
TN1899L	Lycoramine hydrobromide 石蒜胺,Lycoramine HBr
	Lycoramine is a natural alkaloid isolated from Lycoris chinensis.
TN4636	Neoglucobrassicin	Others	Others
	Neoglucobrassicin 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4636，CAS号为 5187-84-8。
TN3796	Dehydrobruceantinol	Others	Others
	Dehydrobruceantinol shows bitter taste and has antileukemic activity.
T80014	Guvacine hydrobromide	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Guvacine hydrobromide为槟榔中提取的生物碱，具有作为GABA摄取抑制剂的活性。该化合物对大鼠GAT-1、GAT-2和GAT-3的GABA摄取抑制作用具有不同的IC50值，分别为39 μM、58 μM及378 μM。
TN5614	Dehydrobruceantin
	Dehydrobruceantin has anti-tuberculosis activity.
TN6072	14-Dehydrobrowniine
	14-Dehydrobrowniine是一种天然产物，属于毛茛科翠雀属，其产品编号为 TN6072，CAS号为 4829-56-5。14-Dehydrobrowniine可用作对照参考。
T82304	Glucobrassicanapin potassium 4-Pentenylglucosinolate potassium
	Glucobrassicanapin (4-Pentenylglucosinolate) potassium 是脂肪族硫代葡萄糖苷类化合物，主要存在于白菜等蔬菜作物中。
TN3797	Dehydrobruceine A	Antifection	Microbiology/Virology
	Dehydrobruceine A shows strong antitrypanosomal activities with IC(50) values in the range of 2.9-17.8nM.
T1255L	Tobramycin Sulfate Dartobcin,Nebcine,Tobraneg,Tobrasix
	Tobramycin Sulfate is a broad-spectrum antibiotic. It is effective against gram-negative bacteria. It especially potent against the Pseudomonas species.
TN3051	4-Methoxyglucobrassicin	Others	Others
	4-Methoxyglucobrassicin 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3051，CAS号为 83327-21-3。
T80013	Arecaidine hydrobromide	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Arecaidine hydrobromide，一种吡啶生物碱，有效抑制GABA吸收。作为H+偶联的氨基酸转运蛋白1（PAT1，SLC36A1）的底物，它竞争性地抑制L-脯氨酸的摄取。
TN4237	Hydrocotarnine hydrobromide	Others	Others
	Hydrocotarnine hydrobromide 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4237，CAS号为 5985-00-2。

天然产物

Anisodamine Hydrobromide

Cat.No: T8304

Synonym: 6-Hydroxyhyoscyamine,氢溴酸山莨菪碱

Target: Adrenergic Receptor, AChR

Galanthamine hydrobromide

Cat.No: T0086

Synonym: Galantamine hydrobromide,Galanthamine HBr,氢溴酸加兰他敏

Target: AChR, AChE

Lappaconitine hydrobromide

Cat.No: T6560

Synonym: 氢溴酸高乌甲素,Lappaconite HBr,Allapinine

Target: Others

Cat.No: T1255

Synonym: NSC 180514,妥布霉素,Nebramycin Factor 6,Deoxykanamycin B

Target: ribosome, Antibacterial, Antibiotic

Cat.No: T0625

Synonym: 3, 7-Dimethylxanthine,可可碱,3,7-Dimethylxanthine

Target: Endogenous Metabolite, PDE, Adenosine Receptor

Halofuginone hydrobromide

Cat.No: T3524

Synonym: 卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐

Target: Others, Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad

(22S,23S)-Homobrassinolide

Cat.No: T41372

Synonym: 油菜素内酯,SSHB

Target: Others

Arecoline hydrobromide

Cat.No: T2198

Synonym: Arecoline HBr,氢溴酸槟榔碱,Arecoline bromide

Target: AChR

Dihydro-β-erythroidine hydrobromide

Cat.No: T11041

Synonym: DHβE hydrobromide

Target: Others

Dehydrobruceine B

Cat.No: T75485

Lycoramine hydrobromide

Cat.No: TN1899L

Synonym: 石蒜胺,Lycoramine HBr

Neoglucobrassicin

Cat.No: TN4636

Target: Others

Dehydrobruceantinol

Cat.No: TN3796

Target: Others

Guvacine hydrobromide

Cat.No: T80014

Target: GABA Receptor

Dehydrobruceantin

Cat.No: TN5614

14-Dehydrobrowniine

Cat.No: TN6072

Glucobrassicanapin potassium

Cat.No: T82304

Synonym: 4-Pentenylglucosinolate potassium

Dehydrobruceine A

Cat.No: TN3797

Target: Antifection

Tobramycin Sulfate

Cat.No: T1255L

Synonym: Dartobcin,Nebcine,Tobraneg,Tobrasix

4-Methoxyglucobrassicin

Cat.No: TN3051

Target: Others

Arecaidine hydrobromide

Cat.No: T80013

Target: GABA Receptor

Hydrocotarnine hydrobromide

Cat.No: TN4237

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01725	Leptin Receptor Protein, Human, Recombinant (His) LEPRD,OB-R,OBR,LEP-R,CD295,leptin receptor	Human	HEK293
	Leptin Receptor or CD295 belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight) and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Leptin Receptor/CD295 is transmembrane catalytic receptors found on NPY/AgRP and alpha-MSH/CART ne...
TMPY-00874	Leptin Receptor Protein, Human, Recombinant (His & hFc) LEP-R,OBR,CD295,OB-R,LEPRD,leptin receptor	Human	HEK293
	Leptin Receptor or CD295 belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight) and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Leptin Receptor/CD295 is transmembrane catalytic receptors found on NPY/AgRP and alpha-MSH/CART ne...
TMPJ-00977	LEPR Protein, Mouse, Recombinant (mFc) LEPR,CD295,OB-R,LEP-R,HuB219,Leptin receptor,OBR,DB...	Mouse	Human Cells
	The Leptin receptor is a member of the Class I cytokine receptor family. It mediates the activities of Leptin, a multi-functional hormone produced primarily by adipose tissues that plays roles in food intake, energy metabolism, angiogenesis, reproduction, hematopoiesis, bone metabolism, and immune function. The human Leptin R gene encodes 1165 amino acids (aa) including a signal peptide, an extracellular region with cytokine receptor homology (CRH), multiple fibronectin type III domains and a WS...
TMPJ-00975	LEPR Protein, Mouse, Recombinant (hFc) CD295,DB,HuB219,OB receptor,LEP-R,Leptin receptor,OBR	Mouse	Human Cells
	The Leptin receptor is a member of the Class I cytokine receptor family. It mediates the activities of Leptin, a multi-functional hormone produced primarily by adipose tissues that plays roles in food intake, energy metabolism, angiogenesis, reproduction, hematopoiesis, bone metabolism, and immune function. The human Leptin R gene encodes 1165 amino acids (aa) including a signal peptide, an extracellular region with cytokine receptor homology (CRH), multiple fibronectin type III domains and a WS...
TMPJ-00411	LEPR Protein, Human, Recombinant (hFc) LEPR,Leptin receptor,OB-R,OB receptor,OBR,CD295,DB,...	Human	Human Cells
	The Leptin receptor is a member of the Class I cytokine receptor family. It mediates the activities of Leptin, a multi-functional hormone produced primarily by adipose tissues that plays roles in food intake, energy metabolism, angiogenesis, reproduction, hematopoiesis, bone metabolism, and immune function. The human Leptin R gene encodes 1165 amino acids (aa) including a signal peptide, an extracellular region with cytokine receptor homology (CRH), multiple fibronectin type III domains and a WS...
TMPJ-00976	LEPR Protein, Mouse, Recombinant (His) OBR,DB,Leptin receptor,OB receptor,CD295,OB-R,LEPR,...	Mouse	Human Cells
	The Leptin receptor is a member of the Class I cytokine receptor family. It mediates the activities of Leptin, a multi-functional hormone produced primarily by adipose tissues that plays roles in food intake, energy metabolism, angiogenesis, reproduction, hematopoiesis, bone metabolism, and immune function. The human Leptin R gene encodes 1165 amino acids (aa) including a signal peptide, an extracellular region with cytokine receptor homology (CRH), multiple fibronectin type III domains and a WS...
TMPH-03038	Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO) Cobra venom factor,Complement C3 homolog,CVFk,CVF	Naja kaouthia	E. coli
	Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely re...
TMPH-03037	Alpha-cobratoxin Protein, Naja kaouthia, Recombinant (GST & His & Myc) Alpha-CT,Alpha-Ctx,Alpha-EPTX-Nk2a,Long neurotoxin 1,Alpha-C...	Naja kaouthia	E. coli
	Monomer: binds with high affinity to muscular (alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND) nAChR (tested on Torpedo californica, Kd=0.2-4.5 nM) and neuronal alpha-7/CHRNA7 nicotinic acetylcholine receptors (Kd=13-105 nM). Also inhibits GABA(A) channels. Heteropentamer targets studied are composed of alpha-1-beta-3-gamma-2 (GABRA1-GABRB3-GABRG2) subunits (IC(50)=236 nM), alpha-1-beta-2-gamma-2 (GABRA1-GABRB2-GABRG2) subunits (IC(50)=469 nM), alpha-2-beta-2-gamma-2 (GABRA2-GABRB2-GABRG2)...
TMPH-00031	Aerolysin Protein, Aeromonas sobria, Recombinant (His & Myc) Hemolysin	Aeromonas sobria	E. coli
	Secreted, cytolytic toxin that forms pores in host membranes after proteolytic removal of a C-terminal propeptide, leading to destruction of the membrane permeability barrier and cell death. The pores are formed by transmembrane beta-strands and are approximately 3 nm in diameter.

重组蛋白

Leptin Receptor Protein, Human, Recombinant (His)

Cat.No: TMPY-01725

Species: Human

Expression System: HEK293

Leptin Receptor Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-00874

Species: Human

Expression System: HEK293

LEPR Protein, Mouse, Recombinant (mFc)

Cat.No: TMPJ-00977

Species: Mouse

Expression System: Human Cells

LEPR Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00975

Species: Mouse

Expression System: Human Cells

LEPR Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00411

Species: Human

Expression System: Human Cells

LEPR Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00976

Species: Mouse

Expression System: Human Cells

Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO)

Cat.No: TMPH-03038

Species: Naja kaouthia

Expression System: E. coli

Alpha-cobratoxin Protein, Naja kaouthia, Recombinant (GST & His & Myc)

Cat.No: TMPH-03037

Species: Naja kaouthia

Expression System: E. coli

Aerolysin Protein, Aeromonas sobria, Recombinant (His & Myc)

Cat.No: TMPH-00031

Species: Aeromonas sobria

Expression System: E. coli

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