193
50
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8800 |
NSAH
2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
NSAH (2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide) 是一种可逆竞争性非核苷类的核苷酸还原酶抑制剂,无细胞 IC50 为 32 μM,基于细胞的 IC50 约为 250 nM。 | |||
T8334 |
CADD522
MFCD00167693,3-{[(3,4-二氯苯基)氨基]羰基}二环[2.2.1]庚-5-烯-2-羧酸 |
Others | Others |
CADD522 (MFCD00167693) 是 runt 相关转录因子-2 (RUNX2)-DNA 结合的抑制剂(IC50:10 nM),具有抗肿瘤作用。 | |||
T2226 |
Pergolide mesylate
甲磺酸培高利特,Pergolide mesylate salt,LY127809,Pergolide methanesulfonate |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Pergolide mesylate salt(LY127809) 是一种有效的,具有口服活性的多巴胺 D1和 D2受体激动剂,是一种 Ergoline 衍生物,可用于帕金森氏病和高泌乳素血症的研究。 | |||
T72662 |
NMDAR/TRPM4-IN-2
|
ERK; TRP/TRPV Channel; NMDAR; iGluR | MAPK; Membrane transporter/Ion channel; Neuroscience |
NMDAR/TRPM4-IN-2 是一种有效的 NMDAR/TRPM4 相互作用界面抑制剂。NMDAR/TRPM4-IN-2 保护小鼠免受 MCAO 诱导的脑损伤和 NMDA 诱导的视网膜神经节细胞丢失。NMDAR/TRPM4-IN-2 具有神经保护活性, 可预防 NMDA 诱导的海马神经元细胞死亡和线粒体功能障碍,其 IC50 值为 2.1 μM。 | |||
T12234 |
NMDA-IN-1
|
NMDAR | Neuroscience |
NMDA-IN-1是一种 NR2B 选择性 NMDA 拮抗剂,对NMDA 的Ki 值为 0.85 nM,对NR2B Ca2+ influx 的IC50值为 9.7 nM。 | |||
T12733 |
Rislenemdaz
CERC-301,MK-0657 |
iGluR | Membrane transporter/Ion channel; Neuroscience |
Rislenemdaz (CERC-301) (CERC-301)是 N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B) 的拮抗剂。 | |||
T5522 |
NMDAR antagonist 1
|
Others; iGluR | Membrane transporter/Ion channel; Neuroscience; Others |
NMDAR antagonist 1 是一种 NR2B 选择性的、口服具有活力的 NMDAR 拮抗剂。 | |||
T16286 |
Nelonemdaz
Neu2000 |
Topoisomerase | DNA Damage/DNA Repair |
Neu2000 is an uncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptor. | |||
T79273 |
NMDA receptor antagonist 6
|
iGluR | Membrane transporter/Ion channel; Neuroscience |
NMDA receptor antagonist6 (compound 13b) 为针对甘氨酸结合位点的NMDA 受体拮抗剂,其展现出对PC12 细胞的神经保护功能,能够抵御NMDA引起的细胞损伤及细胞凋亡。 | |||
T23165 |
PMPA (NMDA antagonist)
|
Others | Others |
PMPA (NMDA antagonist) is a Competitive NMDA receptor antagonist. | |||
T40999 | NMDA receptor antagonist 2 | ||
NMDA receptor antagonist 2 is a highly potent and orally active NR2B subtype-selective antagonist of the N-methyl-D-aspartate (NMDA) receptor. It exhibits remarkable binding affinities, with an IC50 of 1.0 nM and a Ki value of 0.88 nM. This compound finds valuable application in scientific investigations focusing on neuropathic pain and Parkinson’s disease. | |||
T60306 | NMDA receptor antagonist 4 | ||
NMDA receptor antagonist 4 (IIc) 是一个非竞争性、电压依赖的、口服活性的 NMDAR 阻断剂,IC50值为1.93 μM。NMDA receptor antagonist 4 可透过血脑屏障,可用于研究阿兹海默症。 | |||
T60685 |
NMDA receptor modulator 3
|
||
NMDA receptor modulator 3 (Compound 99) 是一种用于神经障碍研究的,NMDA 受体的调节剂。 | |||
T61924 |
NMDA receptor modulator 6
|
||
NMDA receptor modulator 6 (Compound 183) 是有效的 NMDA receptor 调节剂,在神经障碍中具有研究价值 | |||
T69725 |
Amdakefalin
|
||
Amdakefalin is a μ and δ opioid receptors agonist that acts as an analgesic. | |||
T41058 |
Nelonemdaz potassium
Neu2000potassium,Salfaprodil |
||
Nelonemdaz potassium (also known as Salfaprodil) is a potent NR2B-selective and uncompetitive antagonist of N-methyl-D-aspartate (NMDA). This compound exhibits remarkable neuroprotection against cell death induced by both NMDA and free radicals, in addition to its role as a free radical scavenger. | |||
T61470 | NMDA receptor antagonist 5 | ||
NMDA receptor antagonist 5 (Compound 10e), a potent and non-toxic NMDA receptor antagonist, exhibits brain permeability. It is of significance in studying neurological disorders [1]. | |||
T61451 | NMDAR/HDAC-IN-1 | ||
NMDAR/HDAC-IN-1 (Compound 9d) is a potent dual inhibitor of N-methyl-D-aspartate receptors (NMDARs) and histone deacetylases (HDACs). It exhibits a high affinity (Ki = 0.59 μM) for NMDARs, while demonstrating significant inhibitory effects on various HDAC isoforms, including HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8 with IC 50 values of 2.67 μM, 8.00 μM, 2.21 μM, 0.18 μM, and 0.62 μM, respectively. Moreover, NMDAR/HDAC-IN-1 efficiently crosses the blood-brain barrier [1]. | |||
T74854 | GluN2B-NMDAR antagonist-1 | ||
GluN2B-NMDAR antagonist-1 是一种具有口服活性的GluN2B-NMDAR 拮抗剂。GluN2B-NMDAR antagonist-1 具有神经保护活性。 GluN2B-NMDAR antagonist-1 可用于缺血性损伤研究。 | |||
T79374 |
NMDA receptor antagonist 7
|
iGluR | Membrane transporter/Ion channel; Neuroscience |
NMDA receptor antagonist7 (Compound (S)-10a) 为针对 GluN2B 亚基具有选择性的 NMDA 受体拮抗剂,展现出 Ki 值为 93 nM 和 IC50 值为 72 nM。该化合物适用于神经退行性疾病的研究。 | |||
T68357 |
Nelonemdaz Na
|
||
Nelonemdaz Na is a NMDA receptor antagonist potentially for the treatment of stroke. | |||
T60552 |
NMDA receptor modulator 2
|
||
NMDA receptor modulator 2 (Compound 1) 是一种有效的NMDA 受体调节剂,可用于研究神经障碍。 | |||
T63003 |
NMDA receptor potentiator-1
|
||
NMDA receptor potentiator-1 (Compound 1368) 是一种亚基选择性的 NMDA receptor 增强剂。NMDA receptor potentiator-1 对 NR2C 和 NR2D 表达的 IC50 值分别为 4 μM 和 5 μM。 | |||
T60792 | NMDA receptor antagonist-3 | ||
NMDA receptor antagonist-3 是NMDA 受体的拮抗剂。NMDA receptor antagonist-3 在 SH-SY5Y 和人脂肪间充质干细胞中具有显著的回收率(40.0 %,100 μM)和安全的毒理学特性。 | |||
T79375 |
NMDA receptor antagonist 8
|
iGluR | Membrane transporter/Ion channel; Neuroscience |
NMDA receptor antagonist8 (Compound (R)-10a)为针对GluN2B亚基具有选择性的NMDA受体拮抗剂,拥有Ki值为265 nM及IC50值为62 nM,适用于神经退行性疾病的研究。 | |||
T60960 |
NMDA receptor modulator 4
|
||
NMDA receptor modulator 4 (Compound 169) 可用于神经系统疾病的研究,它是 NMDA 受体的有效调节剂。 | |||
T61117 |
NMDA receptor modulator 5
|
||
NMDA receptor modulator 5 (Compound 195), a potent NMDA receptor modulator, exhibits potential for neurological disorder research [1]. | |||
T23014 | MNI-caged-NMDA | Others | Others |
NMDA caged with the photosensitive 4-methoxy-7-nitroindolinyl group | |||
T62126 | (Rac)-NMDAR antagonist 1 | ||
(Rac)-NMDAR antagonist 1 是一种 NMDAR antagonist 1 的消旋体。其中 NMDAR antagonist 1 是一种有效的、口服具有活力的、NR2B 选择性的 NMDAR 拮抗剂。 | |||
T60513 |
NMDA-IN-2
|
||
NMDA-IN-2 (化合物 6b) 是普鲁卡因的衍生物。NMDA-IN-2是 NMDA 受体2B 亚型的抑制剂。 | |||
T13009 |
STAT3-IN-1
|
Apoptosis; STAT | Apoptosis; JAK/STAT signaling; Stem Cells |
STAT3-IN-1 是一种选择性的、口服有效的 STAT3的强效抑制剂,可诱导肿瘤细胞凋亡,其在 HT29 和MDA-MB 231 细胞中的IC50值分别为1.82 μM 和2.14 μM。 | |||
T1859 |
AZD-8055
|
Apoptosis; mTOR; Autophagy | Apoptosis; Autophagy; PI3K/Akt/mTOR signaling |
AZD-8055 是一种选择性、具有口服活性和 ATP 竞争性的 mTOR 抑制剂,IC50为 0.8 nM。AZD-8055 抑制 mTORC1和 mTORC2。 | |||
T70353 |
JG-231
|
HSP | Cytoskeletal Signaling; Metabolism |
JG-231 是 JG-98 类似物,具有抗癌活性。JG-231 对三阴性乳腺癌 (TNBC) 的 MDA-MB-231 异植肿瘤模型具有抑制作用。JG-231 可抑制 Hsp70-BAG3 的相互作用。JG-231 对三阴性乳腺癌 (TNBC) 的 MDA-MB-231 异植肿瘤模型具有抑制作用。 | |||
T28865 |
STAT3-IN-B9
STAT3 IN B9,B9 |
STAT | JAK/STAT signaling; Stem Cells |
STAT3-IN-B9 (B9) 是异常 STAT3 激活的抑制剂,可抑制 MDA-MB-468、MDA-MB-231 和 DU145 等肿瘤细胞的增殖。 | |||
T7311 |
Oxyphenisatin acetate
|
Autophagy | Autophagy |
Oxyphenisatin acetate 是oxyphenisatin 的前体药物,可抑制乳腺癌细胞系 MCF7、T47D、HS578T 和 MDA-MB-468 的生长。 | |||
T14685 |
BMS-986158
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
BMS-986158 是一种BET 抑制剂,在 MDA-MB231 三阴性乳腺癌细胞和 NCI-H211 小细胞肺癌细胞中,对 BET 的IC50分别为 5 和 6.6 nM。 | |||
T36488 |
LYG-202
LYG202,LYG 202 |
Apoptosis; ROS | Apoptosis; Immunology/Inflammation |
LYG-202是一种具有哌嗪替代的新型类黄酮,在体内和体外都具有抗肿瘤作用。LYG-202 诱导 MCF-7、MDA-MB-231 和 MDA-MB-435 细胞凋亡, 增加了细胞内 ROS 的产生。 | |||
T72924 |
VEGFR-3-IN-1
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
VEGFR-3-IN-1 是一种新型有效且具有选择性的 VEGFR3 抑制剂,其 IC50 为 110.4 nM。VEGFR-3-IN-1 具有抗肿瘤活性,可使 VEGFR3 信号通路失活,可抑制 VEGF-C 诱导人真皮淋巴管内皮细胞 (HDLEC)、MDA-MB-231 和 MDA-MB-436 细胞的增殖和迁移,并且能有效抑制乳腺癌的生长。 | |||
T5350 |
JG-98
JG98,JG 98 |
Apoptosis; HSP | Apoptosis; Cytoskeletal Signaling; Metabolism |
JG-98 是一种热休克蛋白 70 (Hsp70)变构抑制剂,可与 Hsp70 上的保守位点紧密结合,打断 Hsp70-Bag3 相互作用。它影响癌细胞和肿瘤相关巨噬细胞,具有抗癌活性。 | |||
T2427 |
EHop-016
EHop 016 |
Rho; Ras | Cell Cycle/Checkpoint; GPCR/G Protein; MAPK |
EHop-016 是一种特异性 Rac GTPase 抑制剂,对 MDA-MB-231 和 MDA-MB-435 细胞中的 Rac1 的 IC50 为 1.1 μM,也可抑制Rac3 。它还抑制 Vav2 与 Rac,Rac 激活的 PAK1 相互作用,片状脂蛋白形成和细胞迁移。 | |||
T60269 |
ZINC194100678
|
PAK | Cytoskeletal Signaling |
ZINC194100678是一种有效的PAK1抑制剂,IC50值为8.37μM 。ZINC194100678 具有较强的抗增殖活性,对MDA-MB-231的IC50值为40.16μM。ZINC194100678可用于癌症的研究。 | |||
T22538 |
A-7 hydrochloride
|
CaMK | Neuroscience |
A-7 hydrochloride 是一种钙调蛋白拮抗剂,会引起 MDA-MB-231细胞中 CD44+CD24-亚群的改变。 | |||
T77650 |
Topoisomerase II inhibitor 14
|
Apoptosis; Antioxidant; Topoisomerase; NO Synthase | Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; oxidation-reduction |
Topoisomerase II inhibitor 14 是一种有效的拓扑异构酶 II 抑制剂,具有抗癌活性和抗氧化活性。Topoisomerase II inhibitor 14 诱导细胞凋亡,并将细胞周期阻滞在 S 期。Topoisomerase II inhibitor 14 可降低 GSH、MDA 和 NO 的量。 | |||
T12344L1 |
OTS186935 FA
OTS186935 FA(2093400-18-9 Free base) |
Histone Methyltransferase | Chromatin/Epigenetic |
OTS186935 FA 是一种蛋白甲基转移酶 SUV39H2 抑制剂。OTS186935 FA在 MDA-MB-231 乳腺癌细胞和 A549 肺癌细胞中抑制肿瘤的生长。 | |||
T2060 |
ELR510444
LR-510444,LR510444,LR 510444 |
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
ELR510444 (LR510444) 是一种新型微管破坏剂, 抑制 MDA-MB-231 细胞增殖,IC50 为 30.9 nM。 | |||
T16021 |
MBQ-167
|
CDK; Ras | Cell Cycle/Checkpoint; GPCR/G Protein; MAPK |
MBQ-167 是一种 Rac/Cdc42 的双重抑制剂,在 MDA-MB-231 细胞中,Rac 1/2/3 和 Cdc42 的 IC50 分别为 103 nM 和 78 nM。 | |||
T77728 |
Tubulin polymerization-IN-55
|
Microtubule Associated | Cytoskeletal Signaling |
Tubulin polymerization-IN-55 是一种高效的 Tubulin Polymerization 抑制剂,具有潜在的抗血管生成和抗肿瘤活性,对 A549、K562、HepG2、MDA-MB-231 和 HFL-1 显示出抗增殖作用。 | |||
T63140 |
LSD1-IN-20
|
Histone Demethylase | Chromatin/Epigenetic |
LSD1-IN-20 是一种有效的 LSD1/G9a 双重抑制剂,其 Ki 值分别为 0.44 和 0.68 μM。LSD1-IN-20 在体外实验中对 THP-1 白血病细胞和 MDA-MB-231 乳腺癌细胞显示出抗增殖活性,72 h 时 IC50 分别为 0.51 和 1.60 μM。 | |||
T41256 |
SP-96
|
Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic |
SP-96 是一种高效的特异性 Aurora B 抑制剂,IC50 为 0.316 nM。 SP-96 在 NCI60 筛选中显示特异性生长抑制,如 MDA-MD-468 (GI50=107 nM)。 SP-96 可用于三阴性乳腺癌研究。 | |||
T2080 |
LCL161
|
IAP | Apoptosis |
LCL161 是一种 SMAC 模拟物,可有效结合并抑制多种 IAP。它抑制 HEK293 细胞中 XIAP 和 MDA-MB-231细胞中 cIAP1的 IC50分别为 35 和 0.4 nM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5669 |
Citric acid monohydrate
|
Others | Others |
Citric acid monohydrate 是一种存在于柑橘类水果中的三羧酸。柠檬酸因其抗氧化特性而被用作药物制剂中的赋形剂。它保持活性成分的稳定性并用作防腐剂。 | |||
T5S0636 |
Citric acid
柠檬酸,Citro,Citretten |
Apoptosis; Others; Endogenous Metabolite; Antibacterial; Antibiotic | Apoptosis; Metabolism; Microbiology/Virology; Others |
Citric acid (Citro) 是柑橘类水果中发现的弱有机三羧酸。柠檬酸是食品添加剂和天然防腐剂。 | |||
T6608 |
NMDA
N-甲基-D-天冬氨酸,N-Methyl-D-aspartic acid |
Endogenous Metabolite; NMDAR; iGluR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
NMDA (N-Methyl-D-aspartic acid) 是一种氨基酸,作为 D-异构体,是谷氨酸受体的 NMDA 受体亚型的定义激动剂。 | |||
T5S1000 |
Sophoraflavanone G
Kushenol F,槐黄烷酮 G,Vexibinol |
Apoptosis | Apoptosis |
Sophoraflavanone G (Kushenol F) 是从苦参中提取到的一种天然产物,通过抑制 MAPK 相关通路诱导 MDA-MB-231 和 HL-60 细胞凋亡,具有抗肿瘤和抗炎特性。 | |||
T3844 |
Deltonin
三角叶薯蓣皂苷 |
ERK; Others; Akt; Endogenous Metabolite | Cytoskeletal Signaling; MAPK; Metabolism; Others; PI3K/Akt/mTOR signaling |
Deltonin 是从盾叶薯蓣中得到的一种甾体皂苷,抑制ERK1/2和AKT 的活化,具有抗肿瘤活性。 | |||
T21771 |
Pyoluteorin
|
Antibiotic | Microbiology/Virology |
Pyoluteorin 是一种抗生素 (antibiotic),可抑制 Oomycete fungi,包括植物病原体 Oomycete fungi,并抑制由该真菌引起的植物病害。 Pyoluteorin 在体外诱导人三阴性乳腺癌 MDA-MB-231 细胞凋亡 (apoptosis)。 Pyoluteorin 可用于人类三阴性乳腺癌的研究。 | |||
T10390 |
Asperphenamate
|
Others; Antifungal | Microbiology/Virology; Others |
Asperphenamate 是 Aspergillus flatiipes 的真菌代谢产物。 T47D 细胞、MDA-MB-231 细胞和 HL-60 细胞的 IC50 分别为 92.3 μM、96.5 μM 和 97.9 μM。 Asperphenamate 具有抗癌作用。 | |||
TQ0298 |
Fagomine
D-Fagomine |
ROS; glycosidase | Immunology/Inflammation; Metabolism |
Fagomine (D-Fagomine) 是一种温和的糖苷酶 (glycosidase) 抑制剂,是1-脱氧野尻霉素 (DNJ) 的类似物,具有降血糖活性,Fagomine 降低了细胞内活性氧(ROS)的产生和丙二醛(MDA)水平。 | |||
TN2083 |
Pinostrobin chalcone
球松素查尔酮,2',3'-二羟基-4'-甲氧基查耳酮 |
||
Pinostrobin chalcone 是一种从豆科植物木豆中分离出的查尔酮类化合物,具有抗癌活性,对 MDA-MB-231 的 IC50 值为 20.42±2.23μg/mL,对 HT-29 结肠癌细胞株的IC50 值为 22.51±0.42 μg/mL。 | |||
T2896 |
Alantolactone
土木香内酯,helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,土木香脑,Inula camphor |
Apoptosis; STAT; TGF-beta/Smad | Apoptosis; JAK/STAT signaling; Stem Cells |
Alantolactone (Inula camphor) 是一种STAT3的选择性抑制剂,可诱导癌症相关的凋亡,具有抗肿瘤活性。 | |||
T4519 |
Alisol A
Alisol-A,泽泻醇 A |
Autophagy | Autophagy |
Alisol A (Alisol-A) 是泽泻中的一种三萜类天然产物,可能是一种自噬诱导剂,具有抗癌活性。 | |||
T5S1607 |
Morusin
Mulberrochromene,桑辛素 |
NF-κB; Antibacterial; STAT | JAK/STAT signaling; Microbiology/Virology; NF-κB; Stem Cells |
Morusin (Mulberrochromene) 是从M. australis 分离的去乙烯基化黄酮,可抑制NF-κB 和STAT3的活性,具有抗菌、抗肿瘤、抗氧化等各种生物活性。 | |||
T8190 |
5-Hydroxyflavone
|
Others | Others |
5-Hydroxyflavone 是类黄酮配体,对 FaDU,MCF-7,U87,MDA-MB-435S,RPE-1 和 HEK293 细胞没有细胞毒性。 | |||
T7032 |
Eupatorin
|
Others; P450 | Metabolism; Others |
Eupatorin 是天然存在的黄酮,可捕获 G2-M 细胞周期,激活多个 caspase、细胞色素 C 的释放、多聚 (ADP-核糖) 聚合酶的裂解,促使凋亡细胞死亡。 | |||
T5S1331 |
Herbacetin
|
c-Met/HGFR; Akt | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
Herbacetin 是一种亚麻籽中的天然类黄酮,具有多种药理活性,如抗氧化、抗炎、抗癌作用。 它是鸟氨酸脱羧酶Ornithine decarboxylase (ODC)变构抑制剂,能够直接与 ODC 上的 Asp44,Asp243 和 Glu384 结合。其中鸟氨酸脱羧酶是多胺生物合成中的限速酶。 | |||
T4964 |
steviolbioside
CCRIS-6025,菊双糖甙,甜菊双糖苷 |
Others | Others |
Steviolbioside (CCRIS-6025) 是一种存在于甜菊叶中的罕见甜味剂。它对几种人类癌细胞有抑制作用,对乳腺癌具有潜在的研究价值。 | |||
T5543 |
TriacetonaMine
四甲基哌啶酮,Odoratine,tempidon,tmpone,Vincubine,2,2,6,6-Tetramethyl-4-piperidinone |
Others | Others |
TriacetonaMine (Vincubine) 是一种合成医药产品、农药和聚合物光稳定剂的中间体。它是热解油的主要组分。它是植物和真菌提取物的人工制品,使用丙酮和氢氧化铵,或在分离过程的不同步骤中天然出现铵盐。 | |||
T2973 |
Astragaloside IV
AST-IV,黄芪甲苷IV,AS-IV,黄芪皂苷 IV |
MMP; ERK; Estrogen/progestogen Receptor; JNK | Endocrinology/Hormones; MAPK; Proteases/Proteasome |
Astragaloside IV (AS-IV) 是从黄芪中分离得到的一种皂苷,抑制ERK1/2和JNK 激活,在乳腺癌细胞 MDA-MB-231 中,下调(MMP)-2和(MMP)-9的信号通路。 | |||
T2966 |
Beta-Sitosterol
Cupreol,谷甾醇,Beta-Sitosterol,β-Sitosterol,Azuprostat,SKF 14463,beta-谷甾醇,22,23-Dihydrostigmasterol,Betaprost |
Apoptosis; Lipase; Endogenous Metabolite | Apoptosis; Metabolism |
Beta-Sitosterol (SKF 14463) 是一种植物甾醇,干扰细胞周期、细胞凋亡、增殖、存活、侵袭、血管生成和炎症等多种细胞信号通路。 | |||
T5S0055 |
Chelidonine
Helidonine,Khelidonin,白屈菜碱,Stylophorin |
Apoptosis; Others; Influenza Virus | Apoptosis; Microbiology/Virology; Others |
Chelidonine (Stylophorin) 是白屈菜中的一种异喹啉生物碱,有抗肿瘤和抗病毒作用。它可导致细胞周期 G2/M 停滞,诱导 caspase 依赖和非依赖性的细胞凋亡。 | |||
T3908 |
10-Gingerol
10-姜酚 |
Apoptosis | Apoptosis |
10-Gingerol 是一种姜根脂的主要刺激性成分,具有抗炎、抗氧化和抗增殖作用,能够抑制 MDA-MB-231 肿瘤细胞的增殖(IC50:12.1 μM)。 | |||
T3929 |
Kaurenoic acid
Kauren-19-Oic Acid,异贝壳杉烯酸,kaurenoate,kaur-16-en-18-oic acid |
Others | Others |
Kaurenoic acid (kaurenoate) 是一种二萜,来源于 Sphagneticola trilobata 中,可以抑制细胞因子的产生和激活 NO–cyclic GMP–PKG–ATP- 敏感型钾通道信号通路,并抑制炎症疼痛。 | |||
T5S0053 |
Coptisine
黄连碱,Coptisin |
Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
Coptisine (Coptisin) 是一种从黄连中分离到的生物碱,是非竞争性的IDO 抑制剂,Ki=为 5.8 μM,IC50=6.3 μM。 | |||
T4S1551 |
Cinnamaldehyde
Cinnamic Aldehyde,肉桂醛 |
HIF | Angiogenesis; Chromatin/Epigenetic |
Cinnamaldehyde (Cinnamic Aldehyde) 具有解热作用。 它是镇静剂。它抑制MDA-MB-435S 细胞的侵袭能力与下调miR-27a 的表达有关。它诱导活性氧的产生,发挥血管扩张和抗癌作用。 它似乎是一种有希望的候选药物,可作为与 5-氟尿嘧啶 (5-FU) 和奥沙利铂 (OXA) 这两种用于 CRC 治疗的化疗药物联合治疗的辅助剂。其作用的可能机制可能涉及药物代谢基因的调节。 它在抑制黑色素瘤的发生和发展方面具有一定的作用,其作用机制可能表现为抑制VEGF 和HIF-α的表达,从而使血管模拟和黑色素瘤细胞新生血管的形成,促进肿瘤的生长。 | |||
T3729 |
Ethyl gallate
Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯 |
MMP; NF-κB; Akt; Antibacterial | Cytoskeletal Signaling; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Ethyl gallate (gallic acid ethyl ester) 是一种非类黄酮酚过氧化氢清除剂。 | |||
T2S1865 |
Octyl gallate
Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯 |
Antioxidant; Influenza Virus; Reactive Oxygen Species; Antibacterial; Antifungal; HSV | Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; oxidation-reduction |
Octyl gallate (Octyl 3,4,5-trihydroxybenzoate) 具有抗菌、抗氧化作用,有选择性和敏感性的荧光特性,广泛用作食品添加剂。它对 HSV-1,水泡性口炎病毒和脊髓灰质炎病毒有显著的抗病毒作用。 | |||
T17155 |
Trabectedin
Ecteinascidin 743,曲贝替定,ET-743 |
Apoptosis; Reactive Oxygen Species | Apoptosis; Immunology/Inflammation; Metabolism; NF-κB |
Trabectedin (Ecteinascidin 743) 是一种四氢异喹啉生物碱,有抗肿瘤的活性, 通过与 DNA 的小沟结合,阻断应激诱导的蛋白质的转录,诱导 DNA 骨架裂解和癌细胞凋亡,并增加 MCF-7 和 MDA-MB-453 细胞中 ROS 的生成。Trabectedin 在软组织肉瘤和卵巢癌中具有的研究价值。 | |||
T5S0106 |
Peimisine
贝母辛,Ebeiensine |
RAAS; AChR | Endocrinology/Hormones; Neuroscience |
Peimisine (Ebeiensine) 非竞争性拮抗气管平滑肌 M 受体,抑制 Ach 引起的平滑肌收缩。它兴奋 β 受体和拮抗内钙释放,促进一氧化氮释放,可舒张气管平滑肌,有平喘作用。 | |||
TN2233 |
Spathulenol
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Antioxidant; Antifungal | Microbiology/Virology; oxidation-reduction |
Spathulenol 是一种来自 Aristolochia yunnanensis 的天然成分,具有抗炎、抗氧化、抗增殖、抗溃疡和抗分枝杆菌活性。 Spathulenol 在 DPPH 系统中显示出显著的抗氧化活性,IC50 为 85.60 μg/mL。 | |||
TN1493 |
Chrysosplenol D
猫眼草酚D |
IL Receptor; NF-κB; JNK | Immunology/Inflammation; MAPK; NF-κB |
Chrysosplenol D 属于甲氧基黄酮类化合物,可诱导 ERK1/2 介导的三阴性人乳腺癌细胞凋亡。它还显示出抗炎和中等抗锥虫活性。 | |||
TN1376 |
α-Solanine
alpha-Solanine,A-茄碱 |
MMP; Akt; PI3K | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Alpha-Solanine alters antioxidative enzyme activities and MDA and PCO concentrations and GST activity in fat body and midgut. | |||
T83104 |
Anthragallol 1,2-dimethyl ether
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Anthragallol 1,2-dimethyl ether 可从O. umbellata提取。该化合物对A549细胞和MDA-MB-231细胞展现细胞毒性,IC50值分别为5.9 μg/ml和8.8 μg/ml。 | |||
TN4330 | Isoshinanolone | Others | Others |
Isoshinanolone shows excellent toxicity with LC(50) values of 1.26 microg/mL. trans-Isoshinanolone shows cytotoxicity against MDA-MB-231 breast cancer cells. | |||
TN1392 |
Anhydrosecoisolariciresinol
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Others | Others |
Anhydrosecoisolariciresinol can significantly decrease the growth of human breast cancer MCF-7 and MDA-MB-231 cell lines at 50 and 100 microM. | |||
TN3009 |
4',5,7-Trihydroxy-6-prenylflavone
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Others | Others |
6-Prenylapigenin(4',5,7-Trihydroxy-6-prenylflavone) shows potent inhibitory activity on melanin formation, it may be potential sources for skin whitening agents. It also shows moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarci | |||
T82344 |
Gambogic acid B
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Gambogic acid B,一种从Garcinia hanburyi树脂中分离得到的活性化合物,对A549、HCT116 和 MDA-MB-231 细胞显示细胞毒性,其IC50值分别为1.60 μM、6.88 μM 和 0.87 μM。 | |||
TN2492 |
1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone
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Others | Others |
1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone has moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacks antifungal activity against Candida albicans. | |||
T83725 |
Nigerose
Sakebiose |
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Nigerose,一种在Acremonium中发现的二糖,当与苷类化合物salidroside联合使用,浓度为150 µM时,可阻止HL-60细胞冷冻保存后的丙二醛(MDA)和活性氧物质(ROS)水平上升,并抑制乳酸脱氢酶(LDH)的释放。 | |||
T2902 |
Costunolide
Costus lactone,NSC 106404,Costunolid,(+)-Costunolide,木香烃内酯 |
Apoptosis; Endogenous Metabolite; Telomerase | Apoptosis; DNA Damage/DNA Repair; Metabolism |
Costunolide (Costus lactone) 是一种天然的倍半萜内酯,具有抗氧化、抗炎、抗过敏、骨重塑、神经保护、促进毛发生长、抗癌和抗糖尿病的特性,可诱导乳腺癌细胞周期阻滞和凋亡。 | |||
TN2752 |
2-Deacetoxytaxinine J
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Others | Others |
2-Deacetoxytaxinine J shows significant in vitro activity against breast cancer cell line at a concentration of 20 microM and 10 microM in MCF-7 and MDA-MB-231 respectively. | |||
TN1741 |
Homomangiferin
高芒果苷 |
Others | Others |
Homomangiferin has important medicinal properties and is widely used to relieve many symptoms, for example coughing and asthma.Homomangiferin shows antitumoural effects against MDA-MB-231 cells. | |||
TN1728 |
Hellebrigenin
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PARP; Akt; CDK | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
Hellebrigenin has anti-hepatoma activities, it induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. Hellebrigenin exhibites moderate to strong activity against human HL-60, SF-295, MDA-MB-435, and HCT-8 cancer cell strains without hemolysis of mouse erythrocytes. | |||
TN2493 | 1,4,5,6-Tetrahydroxy-7-prenylxanthone | Others | Others |
1,4,5,6-Tetrahydroxy-7-prenylxanthone has anti-cancer activity, it shows moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines; it also exhibits moderate activities with GI50 (Growth inhibitory) values of 2. | |||
TN5280 |
(-)-Zeylenol
Zeylenol |
Apoptosis | Apoptosis |
(-)-Zeylenol (Zeylenol) 是一种从 Uvaria grandiflora 的茎中提取的天然产物,具有抗炎、拒食和抗肿瘤生物活性,通过抑制多种炎症介质的合成或释放发挥作用。 zezelenol 对油菜根系生长有抑制作用,具有诱导人乳腺癌 MDA-MB231细胞凋亡的潜力。 | |||
TMA1944 |
Protopine hydrochloride
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EGFR; cAMP | Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Protopine has antiplatelet effects,which is due to inhibition on thromboxane formation and phosphoinositides breakdown and then lead to the decrease of intracellular calcium concentration.Protopine seems to inhibit the heterotypic cell adhesion between MD | |||
TN3401 |
Altenuene
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Antifection | Microbiology/Virology |
Altenuene 是一种霉菌毒素,经常出现在被链格孢属真菌侵染的食物和饲料中。 Altenuene 表现出对金黄色葡萄球菌的中等活性。 Altenuene 还表现出对肺癌细胞系 A549、乳腺癌细胞系 MDA-MB-231 和胰腺癌细胞系 PANC-1 的细胞毒活性。 | |||
TN4261 |
Isoaltenuene
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Antifection | Microbiology/Virology |
Isoaltenuene shows antibiotic activity against Gram-positive bacteria; it also shows a minor phytotoxic activity on tomato leaves at level of 20 ug/spot . Isoaltenuene exhibits cytotoxic activity against lung cancer cell line A549, breast cancer cell line | |||
T35758 | Butyrolactone V | ||
Butyrolactone V is a fungal metabolite that has been found in A. terreus and has antiprotozoal, antioxidant, and anticancer activities.1,2,3 It is active against the P. falciparum strain K1 (IC50 = 7.9 μg/ml) and L. amazonensis promastigotes (IC50 = 23.7 μM).2,1 Butyrolactone V (227 and 454.1 μM) is also active against adult S. mansoni worms.1 It scavenges 2,2-diphenyl-1-picrylhydrazyl and ABTS radicals with IC50 values of 20.7 and 3.7 μM, respectively, in cell-free assays.3 Butyrolactone V also... | |||
T36448 |
(E)-Ajoene
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(E)-Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities.1,2,3,4It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 μg/ml, respectively) and fungi (MICs = 15-50 μg/ml).1(E)-Ajoene inhibits proliferation of a variety of cancer cells, including MDA-MB-231 breast, HeLa cervical, and WHCO1 esophageal cancer cells (IC50s = 18.6, 61, and 39.2 μM, respectively).2It also inhibits human glutathione reductase andT. cruzitrypanoth... | |||
TN3616 |
Cedrelone
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Apoptosis; MMP; Antifection | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Cedrelone 是一种柠檬苦素类化合物,是一种吩嗪生物合成样结构域蛋白 (PBLD) 激活剂。Cedrelone 可诱导癌细胞凋亡 (apoptosis)。Cedrelone 是一种非常有效的细胞凋亡诱导剂,它能导致细胞周期停止。Cedrelone 具有杀虫活性,可抑制 P. saucia 的箭毒生长,并可抑制乳草蝽(Oncopeltus fasciatus)的蜕皮。Cedrelone具有抗肿瘤作用,对SMMC-7721、A-549、MCF-7 和 SW480 等癌细胞株具有显著的细胞毒性。 | |||
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