Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SP-96 是一种高效的特异性 Aurora B 抑制剂,IC50 为 0.316 nM。 SP-96 在 NCI60 筛选中显示特异性生长抑制,如 MDA-MD-468 (GI50=107 nM)。 SP-96 可用于三阴性乳腺癌研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 689 | 现货 | ||
5 mg | ¥ 1,620 | 现货 | ||
10 mg | ¥ 2,610 | 现货 | ||
25 mg | ¥ 4,390 | 现货 | ||
50 mg | ¥ 6,260 | 现货 | ||
100 mg | ¥ 8,590 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,710 | 现货 |
产品描述 | SP-96 is a highly effective and selective inhibitor of Aurora B with an IC50 of 0.316 nM. SP-96 shows selective growth inhibition in NCI60 screening, including MDA-MD-468 (GI50=107 nM). SP-96 can be used in triple negative breast cancer studies. |
靶点活性 | Aurora B:0.316 nM, Aurora A:18.975 nM |
体外活性 | SP-96 (63.2 nM) inhibits Aurora B activity in H460 cells by the characteristics of increased DNA content, and it increases cell volume with enormous nucleus. SP-96 shows >2000 fold selectivity against FLT3 (IC50=1475.6 nM) and KIT (IC50=1307.6 nM). SP-96 (0-2 µM) inhibits Aurora A with IC50 value of 18.975 nM. SP-96 (0-1 µM; 24 hours) is not promiscuous, rather selective for a few cell lines, it inhibits MDA-MB-468, CCRF-CEM, COLO 205 and A498 cell growth with GI50 values of 107 nM,47.4 nM, 50.3 nM and 53.2 nM, respectively[1]. |
分子量 | 453.47 |
分子式 | C25H20FN7O |
CAS No. | 2682114-54-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95 mg/mL (209.50 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.2052 mL | 11.0261 mL | 22.0522 mL | 55.1304 mL |
5 mM | 0.441 mL | 2.2052 mL | 4.4104 mL | 11.0261 mL | |
10 mM | 0.2205 mL | 1.1026 mL | 2.2052 mL | 5.513 mL | |
20 mM | 0.1103 mL | 0.5513 mL | 1.1026 mL | 2.7565 mL | |
50 mM | 0.0441 mL | 0.2205 mL | 0.441 mL | 1.1026 mL | |
100 mM | 0.0221 mL | 0.1103 mL | 0.2205 mL | 0.5513 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
SP-96 2682114-54-9 Cell Cycle/Checkpoint Chromatin/Epigenetic Aurora Kinase Breast Cancer SP96 hematopoiesis Inhibitor SP 96 Triple Negative NCI60 inhibit inhibitor