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177

抑制剂 & 化合物

47

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8239	Cromoglicic acid	Others	Others
	Cromoglicic acid 可防止肥大细胞释放炎性化学物质，例如组胺。
T82424	Experimental allergic encephalitogenic peptide (human)
	Experimental allergic encephalitogenic peptide (human) 为EAE多肽类化合物，能够诱导豚鼠发生脑脊髓炎。
T15598	Isosulfan blue	Others	Others
	Isosulfan blue 是用于淋巴管造影中淋巴管识别的蓝色染料，可用于乳腺癌前哨淋巴结活检，但其在乳腺癌手术中有发生过敏反应的可能性。
T9926	Omalizumab	Others	Others
	Omalizumab 是针对人免疫球蛋白 E 的重组人源化单克隆抗体(KD:0.393 nM)。它能够结合人 FcγRIIb 受体(KD:6.37 uM)。它对持续性过敏性哮喘具有潜在的研究价值。
T5424	Etosalamide 依托柳胺,Ethosalamide	Others	Others
	Etosalamide (Ethosalamide) 是一种解热缓解疼痛的试剂。它具有抗炎作用，可用于研究过敏性疾病。
T7860	SM-324405 SM 324405	TLR	Immunology/Inflammation
	SM-324405 是TLR7的激动剂，EC50 为 50 nM，对人和大鼠 TLR7 的 pEC50值分别为 7.3 和 6.6，可用于过敏性疾病的免疫治疗研究。
T4563	Thonzylamine neohetramine,松齐拉敏	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Thonzylamine (neohetramine) 是可口服的H1组胺受体拮抗剂，具有抗组胺和抗过敏特性，可用于鼻充血、过敏性结膜炎和其他过敏性疾病的研究。
T0211	Azelastine Azelastina,Astelin,Azelastinum,氮卓斯汀	SARS-CoV; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Azelastine (Azelastinum) 是一种选择性组胺 1 拮抗剂，可研究过敏性鼻炎、哮喘、糖尿病高脂血症和 SARS-CoV-2 。
T4348	Syk Inhibitor II	5-HT Receptor; Syk	Angiogenesis; GPCR/G Protein; Neuroscience; Tyrosine Kinase/Adaptors
	Syk Inhibitor II 是一种可渗透细胞、具有 ATP 竞争性的嘧啶-甲酰胺化合物，可选择性且可逆地抑制 Syk，IC50为 41 nM。
T3979	Emedastine LY188695,依美斯汀,Emadine	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Emedastine (LY188695) 是一种可口服的，选择性和高亲和力的组胺 H1受体拮抗剂，Ki 值为 1.3 nM。它是苯并咪唑衍生物，可用于过敏性鼻炎、过敏性皮肤疾病和过敏性结膜炎的研究。
T9043	AS1810722	P450; STAT	JAK/STAT signaling; Metabolism; Stem Cells
	AS1810722 是口服有效的STAT6抑制剂，IC50为 1.9 nM。它是一种稠合双环嘧啶衍生物，对有良好的CYP3A4抑制作用，具有用于过敏性疾病，如哮喘和特应性疾病的研究潜力。
T0118	Mizolastine SL 850324,咪唑司汀,咪唑斯汀	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Mizolastine (SL 850324) 是组胺 H1 受体拮抗剂，IC50为 47 nM。它用于治疗过敏反应，如花粉热和荨麻疹等。
T5310	TR-14035 MDK-1191	Integrin	Cytoskeletal Signaling
	TR-14035 (MDK-1191) 是一种具有口服活性的 α4β7/α4β1整合素双重抑制剂，对 α4β7和 α4β1作用的 IC50值分别为 7 和 87 nM，可用于炎症和自体免疫疾病的研究。
T6242	Rupatadine Fumarate 富马酸卢帕他定,Rinialer,Rupafin,Alergoliber	PAFR; Autophagy; Histamine Receptor	Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Rupatadine Fumarate (Rinialer) 是一种可口服的长效PAF/H1受体的双抑制剂，Ki 值分别为 0.55 μM 和 0.1 μM。它可研究过敏性鼻炎和荨麻疹。
T3185	R112 (E)-Elafibranor	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	R112 ((E)-Elafibranor) 是ATP 竞争性的 Syk 激酶抑制剂，它能够抑制Syk 激酶活性，Ki=6 nM，IC50=226 nM。
T0059	Diphenylpyraline hydrochloride 盐酸双苯比拉林,4-Diphenylmethoxy-1-methylpiperidine hydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Diphenylpyraline hydrochloride (4-Diphenylmethoxy-1-methylpiperidine hydrochloride) 是一种组胺 H1 受体的拮抗剂，抑制多巴胺的吸收。它是可口服的抗组胺试剂，具有抗胆碱和抗过敏作用，可用于缓解过敏性疾病，如鼻炎、花粉热和瘙痒性皮肤疾病等。
T21404	Fluticasone furoate Veramyst,Allermist,Avamys,糠酸氟替卡松,Fluticasone furoate	Glucocorticoid Receptor	Endocrinology/Hormones
	Fluticasone furoate (Avamys) 是一种合成的三氟化皮质类固醇，衍生自氟替卡松，Kd 为 0.3 nM。Fluticasone furoate 具有有效的抗炎、抗哮喘活性和低全身暴露。Fluticasone furoate 可用作过敏性鼻炎治疗研究的鼻喷雾剂。
T12412L	PDK4-IN-1 hydrochloride	Apoptosis; PDK	Apoptosis; PI3K/Akt/mTOR signaling
	PDK4-IN-1 hydrochloride 是一种蒽醌衍生物，对丙酮酸脱氢酶激酶 4有抑制作用，IC50为 84 nM，具有口服活性。它抑制细胞转化和细胞增殖并诱导细胞凋亡。它具有抗过敏，抗糖尿病和抗癌作用。
T0211L	Azelastine hydrochloride Optivar,Azelastine HCl,Allergodil,盐酸氮卓斯汀,Astelin	SARS-CoV; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Azelastine hydrochloride (Astelin) 是一种选择性组胺 1拮抗剂，可研究过敏性鼻炎、哮喘、糖尿病高脂血症和 SARS-CoV-2 。
T5449	Bamaquimast F 10126,L 0042,巴马司特	Proton pump	Membrane transporter/Ion channel
	Bamaquimast (L 0042) 是一种抗哮喘药。
T1030	Triprolidine hydrochloride monohydrate 盐酸曲普利啶,盐酸曲普利啶一水合物,Triprolidine hydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Triprolidine hydrochloride monohydrate 是一种组胺 H1 拮抗剂，用于过敏性鼻炎、哮喘。
T21412	Ketorolac Toradol,Sprix,Acuvail,Macril,酮咯酸,Acular	COX	Immunology/Inflammation; Neuroscience
	Ketorolac (Acuvail) 是非甾体抗炎剂，是非选择性的COX 抑制剂，对 COX-1 和 COX-2 的IC50值分别为 20 和 120 nM。
T1269	Tripelennamine hydrochloride Pyribenzamine hydrochloride,去敏灵,Tripelennamine HCl,Pyribenzamine HCl,盐酸曲吡那敏	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Tripelennamine hydrochloride (Pyribenzamine hydrochloride) 是一种组胺 H1 拮抗剂，具有低镇静作用，但经常刺激胃肠道。
T2335	Ebastine Ebastel,依巴斯汀,LAS-W 090,Ebastin,Kestine,RP64305	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Ebastine (Kestine) 是一种可口服的组胺 H1 受体拮抗剂，用于过敏性鼻炎的症状和慢性特发性荨麻疹的研究。
T0147	Clemastine fumarate HS-592 (fumarate),富马酸氯马斯汀,Meclastine fumarate,Meclastine (fumarate)	Autophagy; Histamine Receptor	Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Clemastine fumarate (Meclastine (fumarate)) 是一种合成乙醇胺，具有抗胆碱能、镇静和组胺 H1 拮抗作用。
T0188	Fluticasone (propionate) 丙酸氟替卡松,CCI-187881,氟替卡松丙酸酯,Fluticasone propionate	Glucocorticoid Receptor; Virus Protease; Estrogen/progestogen Receptor; Phospholipase; Endogenous Metabolite	Endocrinology/Hormones; Metabolism; Microbiology/Virology
	Fluticasone propionate (CCI-187881) 是一种选择性糖皮质激素受体激动剂，是一种局部抗炎激素，亲和力KD 为 0.5 nM。具有抗病毒活性。
T0089	Cetirizine dihydrochloride 盐酸西替利嗪,P071,UCB P071,Cetirizine DiHCl	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Cetirizine dihydrochloride (UCB P071) 是羟嗪的羧化代谢物，是特异性口服有效的 H1 受体长效拮抗剂。它标记抗过敏特性，抑制过敏反应期间嗜酸性粒细胞趋化，可有效治疗过敏性鼻炎、确诊荨麻疹和花粉诱发的哮喘。
T0205	Brompheniramine maleate Dimotane,马来酸溴苯那敏,Rolabromophen,Brompheniramine hydrogen maleate,Dimetane	5-HT Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Brompheniramine maleate (Dimotane) 是一种可口服的丙胺类抗组胺剂，具有抗胆碱能和抗抑郁作用，可用于过敏性鼻炎和缓解疼痛的研究。它是一种选择性组胺 H1 受体拮抗剂，Kd 为 6.06 nM。
T63825	Antiallergic agent-1
	Antiallergic agent-1 是 Src 家族激酶抑制剂，是一种新的有价值的先导化合物，具有作为抗过敏剂的潜力。
T15772	Lodoxamide tromethamine U-42585E	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Lodoxamide tromethamine 是一种的肥大细胞稳定剂，具有抗过敏特性，可用于治疗哮喘和过敏性结膜炎的研究。
T0113	Mebhydrolin napadisylate Incidal,Diazolin,Mebhydroline 1,5-naphthalenedisulfonate salt,美海屈林萘二磺酸盐,Omeril,Diazoline	5-HT Receptor; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Mebhydrolin napadisylate (Incidal) 是一种抗组胺药，用于缓解组胺释放引起的过敏症状，如鼻过敏和过敏性皮肤病。
T7812	Acitazanolast MTCC,阿扎司特,WP-871	Others	Others
	Acitazanolast (WP-871) 是一种抗过敏候选药物。
T68150	Talastine	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Talastine 是一种抗组胺化合物，可诱发过敏性皮疹。
T1531	Mometasone furoate 糠酸莫美他松,糠酸莫米松,Sch32088	Glucocorticoid Receptor	Endocrinology/Hormones
	Mometasone furoate (Sch32088) 是糖皮质激素受体激动剂，具有抗炎和抗过敏作用。它是皮质固醇类试剂，动物模型中，可局部应用于气道炎症、慢性皮肤湿疹、哮喘。
T68094	Lodoxamide ethyl	Others	Others
	lodoxamide ethyl 是一种新的口服活性抗过敏化合物，可用于预防抗原诱导的支气管收缩和阻断皮肤过敏反应。
T1278	Astemizole Laridal,Histaminos,Paralergin,阿司咪唑	Potassium Channel; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Astemizole (Laridal) 是一种长效、非镇静抗组胺药，用于治疗季节性过敏性鼻炎、哮喘、过敏性结膜炎和慢性特发性荨麻疹。它是组胺 H1 受体的拮抗剂，IC50值为 4 nM，还阻断 hERG K+通道，IC50值为 0.9 nM，具有抗胆碱能和止痒作用。
T27159	DF-1111301 DF1111301,DF 1111301	Platelet aggregation; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience; Others
	DF-1111301 是一种具有抗组胺 H1和抗PAF活性的新型抗过敏化合物。
T1170	Olopatadine hydrochloride 盐酸奥洛他定,Olopatadine HCl,KW4679,ALO4943A	5-HT Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Olopatadine hydrochloride (ALO4943A) 是一种抗组胺药，具有稳定肥大细胞的特性，用作治疗过敏性结膜炎的滴眼液。
T1553	Chlorpheniramine maleate 马来酸氯苯那敏,NCI-C55265,Chlorphenamine maleate	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Chlorpheniramine maleate (NCI-C55265) 是一种组胺 H1 拮抗剂，IC50为12 nM，用于过敏反应、花粉热、鼻炎、荨麻疹和哮喘。
T21361	Alclometasone dipropionate Vaderm,Sch 22219,Aclovate,Delonal	Others	Others
	Alclometasone dipropionate （Sch 22219）是一种人工合成的糖皮质激素，属于类固醇化合物，具有抗增生、抗炎、抗过敏、止痒和收缩血管的作用，可用于研究皮肤炎症。
T68128	Picumast
	Picumast 是一种具有抗过敏活性，可被用于治疗哮喘，可能用于治疗治疗过敏性气道疾病。
T21060L	NPC 567 acetate NPC 567 acetate(109333-26-8 Free base)	Bradykinin Receptor	GPCR/G Protein
	NPC 567 acetate 是一种缓激肽 B2 拮抗剂，可用于治疗过敏性气道疾病的研究。
T10945	D18024	Others	Others
	D18024 是一种酞嗪酮的衍生物，显示出抗过敏和抗组胺活性。
T2270	Trans-Tranilast Tranilast trans-,反式-曲尼司特,反-曲尼司特	RAAS	Endocrinology/Hormones
	Trans-Tranilast 是抗过敏剂，可用于过敏性鼻炎、支气管哮喘和特应性皮炎的研究。
T10009	JAK3-IN-7	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK3-IN-7 是一种有效的选择性 JAK3 抑制剂（IC50<0.01 μM），可用于治疗器官移植中的排斥反应、器官移植后的移植物抗宿主反应、自身免疫性疾病、过敏性疾病和慢性骨髓增生性疾病。
T2392	Nafamostat mesylate 甲磺酸萘莫司他,FUT-175	Apoptosis; Serine/threonin kinase; SARS-CoV; Serine Protease	Apoptosis; Cell Cycle/Checkpoint; Metabolism; Microbiology/Virology; Proteases/Proteasome
	Nafamostat mesylate (FUT-175) 是一种广谱丝氨酸蛋白酶抑制剂，血管舒缓素抑制剂，能抑制血液凝固。它通过降低颗粒酶活性和 CTL 细胞溶解抑制T 细胞自身反应活性，可抑制SARS-CoV-2 的激活。它还是潜在的补体抑制剂。
T0298	Dimenhydrinate 茶苯海明,Dramamine,Chloranautine,乘晕宁,Vomex A	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Dimenhydrinate (Vomex A) 是一种乙醇胺和组胺拮抗剂，具有抗过敏活性，可作为抗催吐剂。
T13566	Bamirastine TAK-427	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Bamirastine 抑制配体结合到重组人组胺 H1 受体 (rhH1R)，IC50 值为 17.3 nM。Bamirastine 对过敏性皮肤炎症有抑制作用。
T27244	Efletirizine UCB 28754,UCB-28754,UCB28754	Lipoxygenase; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Efletirizine (UCB-28754) 是一种组胺受体拮抗剂，对5-脂氧合酶(5-LO)具有抑制作用，对可用于局部治疗过敏疾病。
T77456	Lumiliximab IDEC-152,ST-152
	Lumiliximab (IDEC-152) 是一种灵长类化的靶向 CD23 猕猴/人嵌合抗体，对 IgE 抗体的产生有抑制作用，用于研究过敏性疾病。

化合物

Cromoglicic acid

Cat.No: T8239

Target: Others

Experimental allergic encephalitogenic peptide (human)

Cat.No: T82424

Cat.No: T15598

Target: Others

Cat.No: T9926

Target: Others

Cat.No: T5424

Synonym: 依托柳胺,Ethosalamide

Target: Others

Cat.No: T7860

Synonym: SM 324405

Target: TLR

Cat.No: T4563

Synonym: neohetramine,松齐拉敏

Target: Histamine Receptor

Cat.No: T0211

Synonym: Azelastina,Astelin,Azelastinum,氮卓斯汀

Target: SARS-CoV, Histamine Receptor

Syk Inhibitor II

Cat.No: T4348

Target: 5-HT Receptor, Syk

Cat.No: T3979

Synonym: LY188695,依美斯汀,Emadine

Target: Histamine Receptor

Cat.No: T9043

Target: P450, STAT

Cat.No: T0118

Synonym: SL 850324,咪唑司汀,咪唑斯汀

Target: Histamine Receptor

Cat.No: T5310

Synonym: MDK-1191

Target: Integrin

Rupatadine Fumarate

Cat.No: T6242

Synonym: 富马酸卢帕他定,Rinialer,Rupafin,Alergoliber

Target: PAFR, Autophagy, Histamine Receptor

Cat.No: T3185

Synonym: (E)-Elafibranor

Target: Syk

Diphenylpyraline hydrochloride

Cat.No: T0059

Synonym: 盐酸双苯比拉林,4-Diphenylmethoxy-1-methylpiperidine hydrochloride

Target: Histamine Receptor

Fluticasone furoate

Cat.No: T21404

Synonym: Veramyst,Allermist,Avamys,糠酸氟替卡松,Fluticasone furoate

Target: Glucocorticoid Receptor

PDK4-IN-1 hydrochloride

Cat.No: T12412L

Target: Apoptosis, PDK

Azelastine hydrochloride

Cat.No: T0211L

Synonym: Optivar,Azelastine HCl,Allergodil,盐酸氮卓斯汀,Astelin

Target: SARS-CoV, Histamine Receptor

Cat.No: T5449

Synonym: F 10126,L 0042,巴马司特

Target: Proton pump

Triprolidine hydrochloride monohydrate

Cat.No: T1030

Synonym: 盐酸曲普利啶,盐酸曲普利啶一水合物,Triprolidine hydrochloride

Target: Histamine Receptor

Cat.No: T21412

Synonym: Toradol,Sprix,Acuvail,Macril,酮咯酸,Acular

Target: COX

Tripelennamine hydrochloride

Cat.No: T1269

Synonym: Pyribenzamine hydrochloride,去敏灵,Tripelennamine HCl,Pyribenzamine HCl,盐酸曲吡那敏

Target: Histamine Receptor

Cat.No: T2335

Synonym: Ebastel,依巴斯汀,LAS-W 090,Ebastin,Kestine,RP64305

Target: Histamine Receptor

Clemastine fumarate

Cat.No: T0147

Synonym: HS-592 (fumarate),富马酸氯马斯汀,Meclastine fumarate,Meclastine (fumarate)

Target: Autophagy, Histamine Receptor

Fluticasone (propionate)

Cat.No: T0188

Synonym: 丙酸氟替卡松,CCI-187881,氟替卡松丙酸酯,Fluticasone propionate

Target: Glucocorticoid Receptor, Virus Protease, Estrogen/progestogen Receptor, Phospholipase, Endogenous Metabolite

Cetirizine dihydrochloride

Cat.No: T0089

Synonym: 盐酸西替利嗪,P071,UCB P071,Cetirizine DiHCl

Target: Histamine Receptor

Brompheniramine maleate

Cat.No: T0205

Synonym: Dimotane,马来酸溴苯那敏,Rolabromophen,Brompheniramine hydrogen maleate,Dimetane

Target: 5-HT Receptor, Histamine Receptor

Antiallergic agent-1

Cat.No: T63825

Lodoxamide tromethamine

Cat.No: T15772

Synonym: U-42585E

Target: Histamine Receptor

Mebhydrolin napadisylate

Cat.No: T0113

Synonym: Incidal,Diazolin,Mebhydroline 1,5-naphthalenedisulfonate salt,美海屈林萘二磺酸盐,Omeril,Diazoline

Target: 5-HT Receptor, AChR, Histamine Receptor

Cat.No: T7812

Synonym: MTCC,阿扎司特,WP-871

Target: Others

Cat.No: T68150

Target: Histamine Receptor

Mometasone furoate

Cat.No: T1531

Synonym: 糠酸莫美他松,糠酸莫米松,Sch32088

Target: Glucocorticoid Receptor

Lodoxamide ethyl

Cat.No: T68094

Target: Others

Cat.No: T1278

Synonym: Laridal,Histaminos,Paralergin,阿司咪唑

Target: Potassium Channel, Histamine Receptor

Cat.No: T27159

Synonym: DF1111301,DF 1111301

Target: Platelet aggregation, Histamine Receptor

Olopatadine hydrochloride

Cat.No: T1170

Synonym: 盐酸奥洛他定,Olopatadine HCl,KW4679,ALO4943A

Target: 5-HT Receptor, Histamine Receptor

Chlorpheniramine maleate

Cat.No: T1553

Synonym: 马来酸氯苯那敏,NCI-C55265,Chlorphenamine maleate

Target: Histamine Receptor

Alclometasone dipropionate

Cat.No: T21361

Synonym: Vaderm,Sch 22219,Aclovate,Delonal

Target: Others

Cat.No: T68128

NPC 567 acetate

Cat.No: T21060L

Synonym: NPC 567 acetate(109333-26-8 Free base)

Target: Bradykinin Receptor

Cat.No: T10945

Target: Others

Trans-Tranilast

Cat.No: T2270

Synonym: Tranilast trans-,反式-曲尼司特,反-曲尼司特

Target: RAAS

Cat.No: T10009

Target: JAK

Nafamostat mesylate

Cat.No: T2392

Synonym: 甲磺酸萘莫司他,FUT-175

Target: Apoptosis, Serine/threonin kinase, SARS-CoV, Serine Protease

Cat.No: T0298

Synonym: 茶苯海明,Dramamine,Chloranautine,乘晕宁,Vomex A

Target: Histamine Receptor

Cat.No: T13566

Synonym: TAK-427

Target: Histamine Receptor

Cat.No: T27244

Synonym: UCB 28754,UCB-28754,UCB28754

Target: Lipoxygenase, Histamine Receptor

Cat.No: T77456

Synonym: IDEC-152,ST-152

Cat. No.	Product Name	Target	Signaling Pathways
TN1416	Ayanin	IL Receptor; P450; PARP; PDE	Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism
	Ayanin 是从Croton schiedeanus Schlecht 中分离得到的黄酮类物质。它是非选择性的磷酸二酯酶抑制剂，在呼吸道疾病中有研究的价值，如过敏性哮喘等。
T12651	Rabdosiin (+)-Rabdosiin	Others	Others
	Rabdosiin ((+)-Rabdosiin) 是一种分离自 Rabdosia japonicaHara 中的咖啡酸四聚体，具有抗过敏、抗 HIV 和抑制 DNA 拓扑异构酶作用。
T4S0878	Prunetin 樱黄素,Prunusetin	ERK; Dehydrogenase; NF-κB	MAPK; Metabolism; NF-κB
	Prunetin (Prunusetin) 是一种O-甲基化异黄酮，具有抗炎的作用。它是人醛脱氢酶的有效抑制剂。
TN2244	Sulfuretin 硫黄菊素	NF-κB; Autophagy	Autophagy; NF-κB
	Sulfuretin 是竞争性单酚酶和二酚酶活性抑制剂，IC50=13.64 μM。它通过抑制NF-κB 通路来抑制炎症反应。它可用于过敏性气道炎症的研究。它减少氧化应激、血小板聚集和诱变。
T4038	Ectoine THP(B),L-Ectoine,四氢甲基嘧啶羧酸	Others; Antibacterial	Microbiology/Virology; Others
	Ectoine (L-Ectoine) 是生活在极其恶劣环境中的细菌所产生的氨基酸衍生物，是一种天然的细胞保护剂。它具有良好的安全性，可研究过敏性鼻炎。它用作渗透调节相容性溶质，可增加皮肤表面的水合作用并稳定脂质层，常用于皮肤护理。
T2982	Xanthone Genicide,呫吨酮,氧杂蒽酮,Xanthenone,Benzophenone oxide	Apoptosis; Others; Influenza Virus; Antibacterial; Antifungal	Apoptosis; Microbiology/Virology; Others
	Xanthone (Xanthenone) 是一种从山竹果中分离得到的天然产物，具有抗炎，抗氧化，抗肿瘤，抗过敏，抗细菌，抗真菌和抗病毒活性。在癌变的不同阶段可控制细胞分裂和生长，凋亡，炎症和转移。
T2902	Costunolide Costus lactone,NSC 106404,Costunolid,(+)-Costunolide,木香烃内酯	Apoptosis; Endogenous Metabolite; Telomerase	Apoptosis; DNA Damage/DNA Repair; Metabolism
	Costunolide (Costus lactone) 是一种天然的倍半萜内酯，具有抗氧化、抗炎、抗过敏、骨重塑、神经保护、促进毛发生长、抗癌和抗糖尿病的特性，可诱导乳腺癌细胞周期阻滞和凋亡。
T2S2173	(E)-Naringenin chalcone Isosalipurpol,柚皮苷查尔酮,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone,柚皮素查耳酮	Others	Others
	Naringenin chalcone (Isosalipurpol) 是一种黄酮醇生物合成的中间体，在查耳酮异构酶的作用下，自发代谢成柚皮素。它具有抗炎和抗过敏活性。
T4S0398	Rosin 松香树脂	p38 MAPK	MAPK
	Rosin 分离自松木或松树桩中，是一种频繁接触的过敏原，能够导致过敏性接触性皮炎。
T5320	Tulipalin A α-methylene-γ-butyrolactone,2-Methylenebutyrolactone,2-甲烯基丁内酯	Others; Drug Metabolite	Metabolism; Others
	Tulipalin A (α-methylene-γ-butyrolactone) 是来源于郁金香鳞茎的有毒糖苷。Tulipalin A 是引起过敏性接触皮炎的致敏性致敏物 (causative allergen)，在低剂量影响免疫细胞的功能，例如 Jurkat T 细胞。
T2S2362	Dehydrocorydaline nitrate 去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱	BCL; Others; PARP; p38 MAPK; Caspase; Parasite; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Others; Proteases/Proteasome
	Dehydrocorydaline nitrate 是生物碱。Dehydrocorydaline 调节 Bax，Bcl-2蛋白表达，激活 caspase-7，caspase-8，并使 PARP 失活。它能增强 p38 MAPK 活化，具有抗炎、抗癌、抗疟疾等功效。
T2S0504	Ilexoside D	Others	Others
	Ilexoside D has ant-allergic, and anti-coagulant activities, it shows anti-tissue factor activity as well as the antithrombotic activity.
T5666	Dipotassium glycyrrhizinate	Virus Protease	Microbiology/Virology
	Dipotassium glycyrrhizinate 是一种具有抗过敏和抗炎活性的阴离子表面活性剂。
T3872	Nodakenin 紫花前胡苷,(+)-Marmesinin	AChE	Neuroscience
	Nodakenin ((+)-Marmesinin) 是一种Peucedanum decursivum Maxim 根中的主要香豆素苷。它能够抑制乙酰胆碱酯酶活性，IC50=84.7 μM。
TMA1570	Sappanone A	NF-κB; Nrf2	Immunology/Inflammation; NF-κB
	Sappanone A 是一种高异黄烷酮，通过调节 Nrf2 和 NF-κB 表现出抗炎作用。Sappanone A 可以减轻卵清蛋白引起的哮喘中的过敏性气道炎症。
T4S2164	Narirutin Naringenin-7-O-rutinoside,Isonaringin,芸香柚皮苷,柚皮芸香苷	Others; Antibacterial	Microbiology/Virology; Others
	Narirutin (Naringenin-7-O-rutinoside) 是从Citrus unshiu 中分离的活性成分之一，具有抗氧化和抗炎活性。它是一种具有抗结核效力的shikimate 激酶抑制剂。
T4946	(+)-Columbianetin acetate 二氢欧山芹醇醋酸酯,COLUMBIANETIN ACETATE	Others	Others
	(+)-Columbianetin acetate (COLUMBIANETIN ACETATE) 是一种 Columbianetin 异构体。其中Columbianetin 是植物抗毒素，与芹菜贮藏过程中对病原体的抗性有关，表现出良好的抗炎及抗真菌活性。
TN1040	Skullcapflavone II	COX; Antibacterial; TGF-beta/Smad	Immunology/Inflammation; Microbiology/Virology; Neuroscience; Stem Cells
	Skullcapflavone II 是从黄芩中提取的黄酮，具有抗炎作用。它对 M. aurum 和 M. bovisBCG 具有较强的抗菌活性。它还调节破骨细胞的分化、存活和功能。
TN1088	3,5,6,7,8,3',4'-Heptemthoxyflavone 3,3',4',5,6,7,8-heptamethoxyflavone,3,5,6,7,8,3',4'-七甲氧基黄酮	Others	Others
	3,5,6,7,8,3',4'-Heptemthoxyflavone 是来自蜜柑皮中的黄酮，具有抗肿瘤起始活性和抗神经炎症作用。它能通过 cAMP/ERK/CREB 信号诱导脑源性神经营养因子表达，降低 C6 细胞磷酸二酯酶活性。它能抑制胶原酶的活性，增加人真皮成纤维细胞新生细胞中 I 型前胶原含量。
TN1470	Cassiaside B2 决明子苷B2	Phosphatase; MAO; 5-HT Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Cassiaside B2 是蛋白酪氨酸磷酸酶1B (PTP1B) 和人单胺氧化酶A (hMAO-A) 的抑制剂。Cassiaside B2是 5-HT2C 受体的激动剂，具有抗过敏活性。Cassiaside B2 是萘吡喃酮参比提取物（NRE）的有效成分之一。
TN1712	Gossypin	NF-κB; S6 Kinase	MAPK; NF-κB; PI3K/Akt/mTOR signaling
	Gossypin 是一种从Hibiscus vitifolius 中分离得到的黄酮，能够抑制NF-κB 和 NF-κB 的调节基因表达。在小鼠原代骨髓细胞和 RAW264.7 细胞中，它也可抑制 RANKL 诱导的破骨细胞形成。它具有抗氧化、抗炎、抗癌、抗衰老、抗糖尿病和保护肝脏的活性。
T5S1285	(+)-(3R,8S)-Falcarindiol Falcarindiol,镰叶芹二醇	Others	Others
	(+)-(3R,8S)-Falcarindiol 是一种从胡萝卜中得到的聚乙炔，有抗炎、抗肿瘤和抗脂质过氧化活性。它具有抗分歧杆菌作用，对Mycobacterium tuberculosisH37Ra 的 MIC 和 IC50值分别为 24 μM 和 6 μM。
TN1516	Cnidicin 蛇床素,4,9-双[(3-甲基-2-丁烯-1-基)氧基]-7H-呋喃并[3,2-G][1]苯并吡喃-7-酮	NOS; NO Synthase	Immunology/Inflammation
	Cnidicin 是一种香豆素，对肥大细胞脱颗粒及 RAW 264.7 细胞产生一氧化氮具有抑制作用。
T5S1286	(+)-Columbianetin 二氢山芹醇,(S)-Columbianetin,Columbianetin	Antifungal	Microbiology/Virology
	(+)-Columbianetin ((S)-Columbianetin) 是 Columbianetin 的异构体。其中Columbianetin 是一种植物抗毒素，与芹菜贮藏过程中对病原体的抗性有关，具有良好的抗真菌和抗炎作用。
T6S0117	Avicularin Fenicularin,扁蓄苷	ERK	MAPK
	Avicularin (Fenicularin) 具有抗过敏、抗炎、保肝、抗氧化、抗肿瘤等活性。它能通过调节 NF-κB(p65)、COX-2 和 PPAR-γ 的活性来改善人类肝细胞癌。在 LPS 刺激的 RAW 264.7 巨噬细胞中，它通过抑制 ERK 信号通路产生抗炎活性。
T4S1943	Kirenol 奇壬醇,奇任醇,Kirel	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Kirenol (Kirel) 是分离自 Siegesbeckia orientalis 中的，具有抗氧化、抗炎、抗过敏、抗关节炎活性，可用于缓解疼痛的研究。
T17214	Valencene NSC 148969,NSC-148969,NSC148969	Others; Antioxidant; NF-κB	NF-κB; Others; oxidation-reduction
	Valencene (NSC-148969) 是一种从 Cyperus rotundus 中分离出来的倍半萜类化合物，是柑橘类水果和柑橘类衍生气味的香气成分。ValenceneValencene 具有抗过敏、抗炎、抗黑色素生成、和抗氧化活性。通过阻断 NF-κB 通路，Valencene 通过阻断 NF-κB 通路抑制 Th2 趋化因子和促炎性趋化因子的过度表达。
T4518	Licochalcone D	ERK; NF-κB	MAPK; NF-κB
	Licochalcone D 是一种 NF-κB p65的有效抑制剂，是一种存在于 Glycyrrhiza inflate 中的黄酮类化合物，具有抗氧化、抗炎、抗癌等作用。
T2520	Desloratadine Sch34117,地氯雷他定,NSC 675447	Endogenous Metabolite; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Desloratadine (Sch34117) 是非镇静H1抗组胺药 Loratadine 的主要口服代谢物，可减少对支气管平滑肌、毛细血管和胃肠道平滑肌中 H1 受体的典型组胺能作用，包括血管舒张、支气管收缩、血管通透性增加、疼痛、瘙痒和胃肠道平滑肌的痉挛性收缩。它是一种选择性H1受体拮抗剂，具有抗过敏和抗炎活性。
T3S1612	kuwanon G 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G	Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂，具有杀菌作用。
TN5062	Stigmast-4-ene-3,6-dione
	Stigmast-4-ene-3,6-dione has anti-inflammatory and anti-allergic properties.
T39570	Cycloartenyl ferulate Cycloartenolferulate,Cycloartenolferulicacidester,环木菠萝烯醇阿魏酸酯
	Cycloartenyl ferulate (also known as cycloartenol ferulate) is a representative triterpene alcohol with diverse biological properties, such as antioxidant, anti-allergic, anti-inflammatory, and anticancer activities.
TN3513	Bis-5,5-nortrachelogenin	Others	Others
	Bis-5,5-nortrachelogenin has anti-allergic activity, it inhibited NO production with IC50 value of 48.6 microM.
TN3483	Bakkenolide D	IL Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Bakkenolide D has anti-allergic effect, it and bakkenolide D demonstrates inhibitory effect on the trachea contraction induced by histamine in vitro, they have obvious anti-histamine activities.
TN3836	Desacetylmatricarin	Others	Others
	Desacetylmatricarin has anti-allergic property, it shows a potent inhibitory activity upon the beta-hexosaminidase release from RBL-2H3 cells in a dose-dependent manner and the IC50 of 7.5 microM.
TN3482	Bakkenolide B	NOS; COX	Immunology/Inflammation; Neuroscience
	Bakkenolide B has suppressive properties for allergic and inflammatory responses and may be utilized as a potent agent for the treatment of asthma.
TN4429	Leucodin	MMP; TNF	Apoptosis; Proteases/Proteasome
	Leucodin shows high anti-hypercholesterolemic potential. Leucodin may have anti-allergic activity, it shows a potent inhibitory activity upon the beta-hexosaminidase release from RBL-2H3 cells in a dose-dependent manner with IC50 of 80 microM.
TN4392	Koaburaside	IL Receptor; TNF; Influenza Virus	Apoptosis; Immunology/Inflammation; Microbiology/Virology
	Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase. Koaburaside may have anti-allergic inflammatory activity, it can suppress histamine release from mast cells.
TN1845	Kushenol N	Others	Others
	Kushenol N may have anti-allergic activity, it demonstrates significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells .
TN3936	ent-16-Kaurene-3beta,15beta,18-triol	Others	Others
	ent-16-Kaurene-3beta,15beta,18-triol, ent-16-kaurene-3beta,15beta-diol,abbeokutone,and helioscopinolide A possess appreciable anti-allergic activities in RBL-2H3 cells model with IC50 values ranging from 22.5 to 42.2 microM.
TN3325	9-O-Feruloyl-5,5'-dimethoxylariciresinol	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	(+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol may have anti-allergic inflammatory effect, it can inhibit release of histamine from mast cells. It shows cytotoxicity against a small panel of human tumor cell lines, with ED50 values of 9.86 to approxi
T82248	Gymnoside I
	Gymnoside I（化合物1）是糖苷氧基苄基2-异丁基苹果酸，其在小鼠被动皮肤过敏反应（PCA）实验中展现出抗过敏效能。该化合物有望在哮喘、神经衰弱和慢性肝炎治疗研究中应用。
TN3870	Iriflophenone 2-O-Rhamnoside Dimethylmatairesinol	Others	Others
	Dimethylmatairesinol can reduce the amount of Immunoglobulin E (IgE) secreted by human myeloma U266 cells, it has potential as an anti-allergic agent. Dimethylmatairesinol also exhibits significant cytotoxicity against three human tumor cells(A-549 lung c
TN5033	Skullcapflavone I	IL Receptor; Caspase; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome
	Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and inhibit LPS induced IL-6 production in a concentration dependent manner. Skullcapflavone I se
TN2511	Britannilactone diacetate 1,6-O,O-Diacetylbritannilactone	IL Receptor; PARP; ROS; MAPK; Caspase; JAK; JNK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; JAK/STAT signaling; MAPK; Proteases/Proteasome; Stem Cells
	1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound. OODBL has anti-asthmatic activity, it reduces leukotriene C4 pro
T75499	Maceneolignan H
	Maceneolignan H (Compound 8)是一种新的木脂素化合物，从肉豆蔻假种皮中分离而来。它表现为选择性CCR3拮抗剂(EC50=1.4 μM)，具有研究过敏性疾病潜力。
TN4489	Manassantin A	ERK; cAMP; TNF; NF-κB; MAPK; COX; HIF; Prostaglandin Receptor; JNK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Stem Cells
	Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-ÎºB act

天然产物

Cat.No: TN1416

Target: IL Receptor, P450, PARP, PDE

Cat.No: T12651

Synonym: (+)-Rabdosiin

Target: Others

Cat.No: T4S0878

Synonym: 樱黄素,Prunusetin

Target: ERK, Dehydrogenase, NF-κB

Cat.No: TN2244

Synonym: 硫黄菊素

Target: NF-κB, Autophagy

Cat.No: T4038

Synonym: THP(B),L-Ectoine,四氢甲基嘧啶羧酸

Target: Others, Antibacterial

Cat.No: T2982

Synonym: Genicide,呫吨酮,氧杂蒽酮,Xanthenone,Benzophenone oxide

Target: Apoptosis, Others, Influenza Virus, Antibacterial, Antifungal

Cat.No: T2902

Synonym: Costus lactone,NSC 106404,Costunolid,(+)-Costunolide,木香烃内酯

Target: Apoptosis, Endogenous Metabolite, Telomerase

(E)-Naringenin chalcone

Cat.No: T2S2173

Synonym: Isosalipurpol,柚皮苷查尔酮,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone,柚皮素查耳酮

Target: Others

Cat.No: T4S0398

Synonym: 松香树脂

Target: p38 MAPK

Cat.No: T5320

Synonym: α-methylene-γ-butyrolactone,2-Methylenebutyrolactone,2-甲烯基丁内酯

Target: Others, Drug Metabolite

Dehydrocorydaline nitrate

Cat.No: T2S2362

Synonym: 去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱

Target: BCL, Others, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Cat.No: T2S0504

Target: Others

Dipotassium glycyrrhizinate

Cat.No: T5666

Target: Virus Protease

Cat.No: T3872

Synonym: 紫花前胡苷,(+)-Marmesinin

Target: AChE

Cat.No: TMA1570

Target: NF-κB, Nrf2

Cat.No: T4S2164

Synonym: Naringenin-7-O-rutinoside,Isonaringin,芸香柚皮苷,柚皮芸香苷

Target: Others, Antibacterial

(+)-Columbianetin acetate

Cat.No: T4946

Synonym: 二氢欧山芹醇醋酸酯,COLUMBIANETIN ACETATE

Target: Others

Skullcapflavone II

Cat.No: TN1040

Target: COX, Antibacterial, TGF-beta/Smad

3,5,6,7,8,3',4'-Heptemthoxyflavone

Cat.No: TN1088

Synonym: 3,3',4',5,6,7,8-heptamethoxyflavone,3,5,6,7,8,3',4'-七甲氧基黄酮

Target: Others

Cat.No: TN1470

Synonym: 决明子苷B2

Target: Phosphatase, MAO, 5-HT Receptor

Cat.No: TN1712

Target: NF-κB, S6 Kinase

(+)-(3R,8S)-Falcarindiol

Cat.No: T5S1285

Synonym: Falcarindiol,镰叶芹二醇

Target: Others

Cat.No: TN1516

Synonym: 蛇床素,4,9-双[(3-甲基-2-丁烯-1-基)氧基]-7H-呋喃并[3,2-G][1]苯并吡喃-7-酮

Target: NOS, NO Synthase

(+)-Columbianetin

Cat.No: T5S1286

Synonym: 二氢山芹醇,(S)-Columbianetin,Columbianetin

Target: Antifungal

Cat.No: T6S0117

Synonym: Fenicularin,扁蓄苷

Target: ERK

Cat.No: T4S1943

Synonym: 奇壬醇,奇任醇,Kirel

Target: Wnt/beta-catenin

Cat.No: T17214

Synonym: NSC 148969,NSC-148969,NSC148969

Target: Others, Antioxidant, NF-κB

Cat.No: T4518

Target: ERK, NF-κB

Cat.No: T2520

Synonym: Sch34117,地氯雷他定,NSC 675447

Target: Endogenous Metabolite, Histamine Receptor

Cat.No: T3S1612

Synonym: 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G

Target: Phosphatase, Antibacterial, Bombesin Receptor, AChR, AChE, Glucosidase

Stigmast-4-ene-3,6-dione

Cat.No: TN5062

Cycloartenyl ferulate

Cat.No: T39570

Synonym: Cycloartenolferulate,Cycloartenolferulicacidester,环木菠萝烯醇阿魏酸酯

Bis-5,5-nortrachelogenin

Cat.No: TN3513

Target: Others

Cat.No: TN3483

Target: IL Receptor, Histamine Receptor

Desacetylmatricarin

Cat.No: TN3836

Target: Others

Cat.No: TN3482

Target: NOS, COX

Cat.No: TN4429

Target: MMP, TNF

Cat.No: TN4392

Target: IL Receptor, TNF, Influenza Virus

Cat.No: TN1845

Target: Others

ent-16-Kaurene-3beta,15beta,18-triol

Cat.No: TN3936

Target: Others

9-O-Feruloyl-5,5'-dimethoxylariciresinol

Cat.No: TN3325

Target: IL Receptor, TNF

Cat.No: T82248

Iriflophenone 2-O-Rhamnoside

Cat.No: TN3870

Synonym: Dimethylmatairesinol

Target: Others

Skullcapflavone I

Cat.No: TN5033

Target: IL Receptor, Caspase, Prostaglandin Receptor

Britannilactone diacetate

Cat.No: TN2511

Synonym: 1,6-O,O-Diacetylbritannilactone

Target: IL Receptor, PARP, ROS, MAPK, Caspase, JAK, JNK, STAT

Maceneolignan H

Cat.No: T75499

Cat.No: TN4489

Target: ERK, cAMP, TNF, NF-κB, MAPK, COX, HIF, Prostaglandin Receptor, JNK, STAT

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