store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lodoxamide tromethamine 是一种的肥大细胞稳定剂,具有抗过敏特性,可用于治疗哮喘和过敏性结膜炎的研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 218 | 现货 | ||
5 mg | ¥ 493 | 现货 | ||
10 mg | ¥ 747 | 现货 | ||
25 mg | ¥ 1,220 | 现货 | ||
50 mg | ¥ 1,730 | 现货 | ||
100 mg | ¥ 2,490 | 现货 | ||
200 mg | ¥ 3,680 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 593 | 现货 |
产品描述 | Lodoxamide tromethamine is a mast cell stabilizer with anti-allergic properties and can be used in studies about the treatment of asthma and allergic conjunctivitis. |
体外活性 | In purified rat peritoneal mast cells, Lodoxamide tromethamine inhibits ionophore-induced 45Ca influx with associated histamine release[1]. Lodoxamide tromethamine significantly and dose-dependently inhibits the chemotactic response of eosinophils to fMLP and to IL-5. Lodoxamide tromethamine strongly inhibits the release of eosinophil peroxidase after IgA-dependent activation and inhibits the release of eosinophil cationic protein and eosinophil-derived neurotoxin to a lesser extent[4]. |
体内活性 | In Ascaris-sensitized anesthetized rhesus monkeys, Lodoxamide tromethamine significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge[1]. The addition of Lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution increases oxygenation, decreases microvascular permeability, and increases compliance thereby decreasing lung reperfusion injury[2]. |
别名 | U-42585E |
分子量 | 553.91 |
分子式 | C19H28ClN5O12 |
CAS No. | 63610-09-3 |
store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 15 mg/mL (27.1 mM), Sonication and heating are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.8053 mL | 9.0267 mL | 18.0535 mL | 45.1337 mL |
5 mM | 0.3611 mL | 1.8053 mL | 3.6107 mL | 9.0267 mL | |
10 mM | 0.1805 mL | 0.9027 mL | 1.8053 mL | 4.5134 mL | |
20 mM | 0.0903 mL | 0.4513 mL | 0.9027 mL | 2.2567 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Lodoxamide tromethamine 63610-09-3 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor U-42585E Inhibitor inhibitor inhibit