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Search Results for " tnf-a "

Targets Recommended: TNF

235

抑制剂 & 化合物

62

天然产物

5

化合物库

261

重组蛋白

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Cat. No.	Product Name
L4700	免疫/炎症分子化合物库		4720 compounds
	4720 种具有抗炎症活性的化合物的特有集合，可用于高通量筛选和高内涵筛选；
L3800	NF-κB 通路分子库		729 compounds
	729 个 NF-κB 信号通路相关的小分子化合物的特有集合，用于高通量、高内涵筛选；
L9810	抗纤维化化合物库		1155 compounds
	1155 种潜在的抗纤维化分子，是研究纤维化的有效工具，可以用于高通量筛选和高内涵筛选；
L3600	细胞因子抑制剂库		604 compounds
	604 个与细胞因子紧密相关的化合物集合，是高通量、高内涵筛选的良好载体；
L9840	抗阿尔茨海默症化合物库		986 compounds
	986 种阿尔茨海默症相关的化合物集合，可用于高通量和高内涵筛选；

化合物库

免疫/炎症分子化合物库

Cat.No: L4700

Compounds: 4720

NF-κB 通路分子库

Cat.No: L3800

Compounds: 729

抗纤维化化合物库

Cat.No: L9810

Compounds: 1155

细胞因子抑制剂库

Cat.No: L3600

Compounds: 604

抗阿尔茨海默症化合物库

Cat.No: L9840

Compounds: 986

Cat. No.	Product Name	Target	Signaling Pathways
T77494	TNF-α-IN-9	TNF	Apoptosis
	TNF-α-IN-9 是一种 NDM-1 inhibitor-3类似物，是一种 TNF-α 抑制剂。TNF-α-IN-9 显示低抑制活性。
T19584L	TNF-α (31-45), human acetate TNF-α (31-45), human acetate(144796-71-4 free base)	Others	Others
	TNF-α (31-45), human acetate(144796-71-4 free base) 是一种肿瘤坏死因子-α 的肽。
T4637	R-7050 TNF-α Antagonist III	TNF	Apoptosis
	R-7050 (TNF-α Antagonist III) 是一种肿瘤坏死因子受体拮抗剂，对 TNFα具有更高选择性。
T21445	Naphazoline AK-Con,Naphcon-a,Clear Eyes,All Clear,萘甲唑林	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Naphazoline (Naphcon-a) 是一种具有显着 α 肾上腺素能活性的拟交感神经化合物。萘甲唑啉可用作血管收缩剂，当应用于粘膜时可快速减少肿胀。
T36127	TNF-α Antagonist
	TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-κB (RANK) and TNF-α's recruitment and activation of osteoclasts. TNF-α antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destr...
T13175	TNF-α-IN-1	TNF	Apoptosis
	TNF-α-IN-1是 TNF-α 抑制剂。
T36097	TNF-α-IN-2
	TNF-α-IN-2 is a highly potent and orally bioavailable inhibitor of tumor necrosis factor alpha (TNFα), exhibiting an IC50 of 25 nM in the HTRF assay. It exerts its inhibitory effects by inducing conformational changes in the TNFα trimer upon binding, resulting in disrupted signaling when the trimer interacts with TNFR1. TNF-α-IN-2 holds promise as a valuable tool for investigating the pathogenesis of rheumatoid arthritis[1].
TP1537	TNF-α (10-36), human
	TNF-α (10-36), human is a potent pro-inflammatory cytokine involved in the acute phase stress response.
T40321	TNF-α-IN-6
	TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα ( K D = 6.8 nM).
T19584	TNF-α (31-45), human	Others	Others
	TNF-α (31-45), human is a peptide of tumor necrosis factor-α.
TP1626	TNF-α (46-65), human
	Human TNF alpha (46-65) peptide.
TP1479	TNF-α (10-36), human (TFA) (144796-70-3 free base) TNF-α (10-36), human (TFA)
	TNF-α (10-36), human (TFA) is a peptide of human TNF-α.
TP1669	TNF-α (46-65), human TFA (144796-72-5 free base) TNF-α (46-65), human TFA
	TNF-α (46-65), human (TFA) is a peptide of human TNF-α.
TP1636	TNF-α (31-45), human TFA (144796-71-4 free base) TNF-α (31-45), human TFA
	TNF-α (31-45), human (TFA) is a peptide of tumor necrosis factor-α.
T37445	Etanercept	TNF	Apoptosis
	Etanercept is a dimeric fusion protein that serves as a competitive TNF inhibitor by binding to TNF. It effectively inhibits the binding of both TNF-α and TNF-β to the TNF receptors on cell surfaces, thereby rendering TNF biologically inactive. Etanercept has demonstrated efficacy in treating rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis.
T14848	C 87	Others; TNF	Apoptosis; Others
	C 87 是一种小分子 TNF-α 抑制剂。 C 87 直接与 TNFα 结合，有效抑制 TNF-α 诱导的细胞毒性 (IC50 = 8.73 μM)，并有效阻断 TNF-α 触发的信号传导活动。
T12985	SPD304 dihydrochloride	TNF	Apoptosis
	SPD304 dihydrochloride 是 TNF-α 的特异性抑制剂，IC50 为 22 µM。 SPD304 dihydrochloride 促进 TNF 三聚体的解离。
T83628	TNF/IFNγ-IN-1	Antioxidant; TNF; COX	Apoptosis; Immunology/Inflammation; Neuroscience; oxidation-reduction
	TNF/IFNγ-IN-1(TGA) 是 TNF 和 IFN-γ 的双重抑制剂。TNF/IFNγ-IN-1 具有潜在的抗氧化和抗炎活性，可用于类似阿尔茨海默等的神经退行性疾病。
T60124	1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea	TNF	Apoptosis
	1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea 是一种能够激动 TNF-α的化合物，可以诱导细胞分泌 TNF-α。
T30531	BMS-561392 DPC333,DPC 333,DPC-333,BMS561392,BMS 561392	TNF	Apoptosis
	BMS-561392 (DPC333)是一种肿瘤坏死因子-α(TNF-α)转化酶抑制剂。
T8692	(Rac)-Benpyrine	TNF	Apoptosis
	(Rac)-Benpyrine 是一种有效且具有口服活性的 TNF-α 抑制剂，是Benpyrine 的外消旋体。它可研究TNF-α介导的炎症和自身免疫性疾病。
T9840	Ataquimas	Immunology/Inflammation related	Immunology/Inflammation
	Ataquimas 抑制来自人类细胞的 IL-5 以及 TNF-a、IL-4 和 GM-CSF 的分泌。
T21853	(E)-AG 556	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	(E)-AG 556 是有效的、选择性 EGFR 抑制剂。(E)-AG 556阻断 LPS 诱导的促炎因子 TNF-α 的产生。
T9921	Infliximab	TNF	Apoptosis
	Infliximab 是一种与 TNF-α特异性结合的嵌合单克隆 IgG1 抗体，可阻止 TNF-α与 TNFR1和 TNFR2 的相互作用，用于治疗克罗恩病和类风湿性关节炎。
T8845	UTL-5g 3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-,GBL-5g	TNF	Apoptosis
	UTL-5g (3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-) 是一种抗炎性TNF-α抑制剂，可通过抑制 TNF-α 等因子降低顺铂引起的肝毒性、肾毒性和骨髓毒性，具有化学保护和肝脏放射保护作用。
T71691	Pumafentrine BY 343	PDE	Metabolism
	Pumafentrine（BY 343）是 PDE3/PDE4双重抑制剂，可降低小鼠实验性结肠炎的临床评分和 TNF 表达。
T3561	CPI1189 CPI-1189,REN-1189,CPI 1189	TNF	Apoptosis
	CPI1189 (REN-1189) 是 TNF-α 释放抑制剂，具有神经保护作用及抗氧化作用。它可用于研究 HIV 相关神经毒性，具有成为 HIV 相关 CNS 疾病患者神经保护治疗药物的潜能。
T5101	BW-A 78U BW-A78U	PDE	Metabolism
	BW-A 78U 抑制 PDE4，其 IC50值为 3 μM。
T4412	Roquinimex Linomide,罗喹美克,LS2616,FCF89,ABR212616	TNF	Apoptosis
	Roquinimex (FCF89) 是一种喹啉衍生物免疫刺激剂，可增加 NK 细胞活性和巨噬细胞的细胞毒性，抑制血管生成并减少 TNF α 的分泌。
T11742	K-7174	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	K-7174 是一种新型细胞粘附抑制剂，抑制由 IL-1β 或 TNF-α 诱导的血管细胞粘附分子 1 (VCAM-1) 的表达。
T64349	Necroptosis-IN-3 Cyclohexanecarboxamide, N-(2-thienylmethyl)-	Necroptosis	Apoptosis
	Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-)(Compound 69) 是一种坏死性凋亡 (necroptosis) 抑制剂，抑制 TNF-α 诱导的坏死性凋亡。Necroptosis-IN-3(Compound 69) 也抑制 11β-HSD1。
T1847	Necrostatin-1 Nec-1,Necrostatin 1	Indoleamine 2,3-Dioxygenase (IDO); Ferroptosis; Autophagy; RIP kinase	Apoptosis; Autophagy; Metabolism; NF-κB
	Necrostatin-1 (Nec-1) 是一种坏死性凋亡抑制剂和 RIP1 抑制剂，具有特异性。Necrostatin-1 抑制 TNF-α 诱导的坏死性凋亡。Necrostatin-1 也可以抑制 IDO。
T4319	Hispidol (Z)-Hispidol	TNF	Apoptosis
	Hispidol ((Z)-Hispidol) 是一种炎症性肠病的潜在治疗剂，可抑制 TNF-α 诱导的单核细胞与结肠上皮细胞的粘附，IC50 为 0.50 μM。
T22021	ACHP IKK-2 Inhibitor VIII	IκB/IKK	NF-κB
	ACHP(IKK-2 Inhibitor VIII) 是一种新型具有选择性和高效性的 IKK 抑制剂，对IKK-α和IKK-β 具有抑制作用。ACHP 具有抗 HIV-1 活性，通过抑制 NF-κB 激活来抑制 HIV-1 长末端重复序列（LTR）驱动的基因表达，抑制 TNF-α 诱导的 NF-κB （p65）募集到 HIV-1 LTR。
T37558	Necrostatin-5 Nec-5	RIP kinase; Necroptosis	Apoptosis; NF-κB
	Necrostatin-5 (Nec-5)是一种RIP1激酶的选择性抑制剂，也是一种细胞坏死抑制剂，可防止TNF-α处理的fadd 缺陷Jurkat 细胞死亡，EC50值为240 nM。
T64359	Anti-inflammatory agent 36	Immunology/Inflammation related	Immunology/Inflammation
	Anti-inflammatory agent 36 是一种抗炎剂。它对LPS 诱导的RAW 264.7细胞释放TNF-a 和IL-6具有剂量依赖性的抑制作用，IC50分别为3.69uM 和3.68uM。
TP1615L	IKKγ NBD Inhibitory Peptide acetate IKKγ NBD Inhibitory Peptide acetate(372146-18-4 free base)	NF-κB	NF-κB
	IKKγ NBD Inhibitory Peptide acetate 是一种 NEMO 结合结构域肽（NBD 肽）乙酸盐，对应于 NEMO 氨基末端 α-螺旋区域。它显示可阻断 TNF-α 诱导的 NF-kB 活化。
T9645	CU-115 N-(4-(3,5-bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide	TLR	Immunology/Inflammation
	CU-115 是一种有效的，选择性的 TLR8 拮抗剂。CU-115对 TLR8 和 TLR7的 IC50分别为1.04 µM 和=>50 µM。THP-1 细胞中，CU-115 减少了 R-848 激活的 TNF-α 和 IL-1β 的产生。
T22168	Vialinin A Terrestrin A	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	Vialinin A (Terrestrin A) (Terrestrin A) 是一种具有抗氧化性质的对三苯化合物。Vialinin A (Terrestrin A) 是 TNF-α，USP4, USP5 和 SENP1 特异性蛋白酶 1 的有效抑制剂。Vialinin A (Terrestrin A) 可用于自身免疫疾病和癌症研究。
T10866	Cot inhibitor-2	TNF; MAPK	Apoptosis; MAPK
	Cot inhibitor-2 是一种 cot (Tpl2/MAP3K8) 抑制剂(IC50 : 1.6 nM)，具有有效性，选择性和口服活性。Cot inhibitor-2 对LPS 刺激的人全血中 TNF-α 的产生具有抑制作用，IC50 为 0.3 μM。
T22698	TLR3-IN-1 CU CPT 4a	TLR	Immunology/Inflammation
	TLR3-IN-1 (CU CPT 4a) 是一种选择性的TLR3信号抑制剂，在 RAW 264.7 细胞中 IC50 为 3.44 μM。它可以抑制 TLR3/dsRNA 复合物介导的下游信号通路，并抑制全细胞中 TNF-α 和 IL-1β 的产生。
T4062	CAY10602	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	CAY10602 是一种SIRT1激活剂，可剂量依赖性地抑制 THP-1 细胞中脂多糖对 TNF-α 的 NF-κB 依赖性诱导。
T60657	(R)-STU104	TNF; MAPK	Apoptosis; MAPK
	(R)-STU104 是一种新型 TAK1-MKK3 蛋白-蛋白相互作用（PPI）抑制剂，抑制 TNF-α，通过与 MKK3 结合并破坏TAK1磷酸化MKK3来抑制TAK1/MKK3/p38/MnK1/MK2/elF4E信号通路。(R)-STU104 是治疗溃疡性结肠炎的候选化合物。
T61111	UCB-5307	TNF	Apoptosis
	UCB-5307 是一种小分子化合物，可在体外抑制 TNFR1 信号转导和下游功能。人 TNFα 的 KD 为 9 nM。 TNF 直接通过缓慢的结合动力学结合，KD = 6 nM。 UCB-5307 可以通过预制的 hTNF/hTNFR1 复合物。
T12997	SR-318	p38 MAPK; TNF	Apoptosis; MAPK
	SR-318 是p38 MAPK 的选择性抑制剂，对 p38α，p38β 和 p38α/β 的IC50分别为 5 nM，32 nM 和 6.11 μM。它有效抑制全血中TNF-α的释放，IC50为 283 nM。它显示出抗癌和抗炎活性。
T36524	IKK2-IN-4 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide,IKK2 Inhibitor IV	IκB/IKK; TNF	Apoptosis; NF-κB
	IKK2-IN-4 (IKK2 Inhibitor IV)是一种高效的 IKK-2 抑制剂，IC50 值为 25 nM。IKK2-IN-4 对 LPS 诱导的 PBMC 中 TNFα 的产生有抑制作用。
T77484	Atibuclimab	TNF	Apoptosis
	Atibuclimab 是一种靶向 CD14 的嵌合单克隆抗体，由小鼠可变区和人类 IgG4 Fc 区构成。Atibuclimab 可用于治疗肌萎缩侧索硬化症。Atibuclimab 可减少 LPS 诱导的病症，并对 LPS 诱导的促炎细胞因子释放有抑制作用，可延迟抗炎细胞因子可溶性 TNF 受体 I 型的释放，
T12781	RV01	Others	Others
	RV01 是一种新型的白藜芦醇喹啉取代类似物，可抑制 DNA 损伤，降低乙醇诱导的乙醛脱氢酶 (ALDH2) 的 mRNA 表达，具有清除羟自由基的活性。RV01 降低 iNOS 的表达，具有抗神经炎症作用。RV01降低肿瘤坏死因子-a (TNF-a)和白细胞介素-6 (IL-6) mRNA 水平和分泌，抑制lps 诱导的ROS 生成和烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶活化，降低toll 样受体4 (TLR4)的蛋白表达，抑制lps 诱导的丝裂原活化蛋白激酶(MAPK)和核转录因子-кB (NF-кB)信号通路的激活。
T24816	SP-100030 SP100030,SP 100030	NF-κB	NF-κB
	SP-100030 是一种有效的 NF-κB 和激活蛋白-1 (AP-1) 双抑制剂 (IC50 分别为 50 和 50 nM)。SP-10003 抑制 Jurkat 和其他T 细胞系产生的 IL-2、IL-8 和 TNF-α 的产生。SP-100030 降低小鼠胶原性关节炎 (CIA)。
T1642	Lenalidomide 来那度胺,CC-5013	Apoptosis; TNF; Ligand for E3 Ligase; Molecular Glues	Apoptosis; PROTAC
	Lenalidomide (CC-5013) 是 Thalidomide 的衍生物，也是具有口服活性免疫调节剂，以分子胶的方式作用。它是泛素 E3 连接酶 cereblon (CRBN) 的配体，可通过 CRBN-CRL4 泛素连接酶对两种淋巴转录因子 IKZF1 和 IKZF3 进行选择性泛素化和降解。

化合物

Cat.No: T77494

Target: TNF

TNF-α (31-45), human acetate

Cat.No: T19584L

Synonym: TNF-α (31-45), human acetate(144796-71-4 free base)

Target: Others

Cat.No: T4637

Synonym: TNF-α Antagonist III

Target: TNF

Cat.No: T21445

Synonym: AK-Con,Naphcon-a,Clear Eyes,All Clear,萘甲唑林

Target: Adrenergic Receptor

TNF-α Antagonist

Cat.No: T36127

Cat.No: T13175

Target: TNF

Cat.No: T36097

TNF-α (10-36), human

Cat.No: TP1537

Cat.No: T40321

TNF-α (31-45), human

Cat.No: T19584

Target: Others

TNF-α (46-65), human

Cat.No: TP1626

TNF-α (10-36), human (TFA) (144796-70-3 free base)

Cat.No: TP1479

Synonym: TNF-α (10-36), human (TFA)

TNF-α (46-65), human TFA (144796-72-5 free base)

Cat.No: TP1669

Synonym: TNF-α (46-65), human TFA

TNF-α (31-45), human TFA (144796-71-4 free base)

Cat.No: TP1636

Synonym: TNF-α (31-45), human TFA

Cat.No: T37445

Target: TNF

Cat.No: T14848

Target: Others, TNF

SPD304 dihydrochloride

Cat.No: T12985

Target: TNF

TNF/IFNγ-IN-1

Cat.No: T83628

Target: Antioxidant, TNF, COX

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea

Cat.No: T60124

Target: TNF

Cat.No: T30531

Synonym: DPC333,DPC 333,DPC-333,BMS561392,BMS 561392

Target: TNF

(Rac)-Benpyrine

Cat.No: T8692

Target: TNF

Cat.No: T9840

Target: Immunology/Inflammation related

Cat.No: T21853

Target: EGFR

Cat.No: T9921

Target: TNF

Cat.No: T8845

Synonym: 3-Isoxazolecarboxamide, N-(2,4-dichlorophenyl)-5-methyl-,GBL-5g

Target: TNF

Cat.No: T71691

Synonym: BY 343

Target: PDE

Cat.No: T3561

Synonym: CPI-1189,REN-1189,CPI 1189

Target: TNF

Cat.No: T5101

Synonym: BW-A78U

Target: PDE

Cat.No: T4412

Synonym: Linomide,罗喹美克,LS2616,FCF89,ABR212616

Target: TNF

Cat.No: T11742

Target: IL Receptor, TNF

Necroptosis-IN-3

Cat.No: T64349

Synonym: Cyclohexanecarboxamide, N-(2-thienylmethyl)-

Target: Necroptosis

Cat.No: T1847

Synonym: Nec-1,Necrostatin 1

Target: Indoleamine 2,3-Dioxygenase (IDO), Ferroptosis, Autophagy, RIP kinase

Cat.No: T4319

Synonym: (Z)-Hispidol

Target: TNF

Cat.No: T22021

Synonym: IKK-2 Inhibitor VIII

Target: IκB/IKK

Cat.No: T37558

Synonym: Nec-5

Target: RIP kinase, Necroptosis

Anti-inflammatory agent 36

Cat.No: T64359

Target: Immunology/Inflammation related

IKKγ NBD Inhibitory Peptide acetate

Cat.No: TP1615L

Synonym: IKKγ NBD Inhibitory Peptide acetate(372146-18-4 free base)

Target: NF-κB

Cat.No: T9645

Synonym: N-(4-(3,5-bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide

Target: TLR

Cat.No: T22168

Synonym: Terrestrin A

Target: DUB

Cot inhibitor-2

Cat.No: T10866

Target: TNF, MAPK

Cat.No: T22698

Synonym: CU CPT 4a

Target: TLR

Cat.No: T4062

Target: Sirtuin

Cat.No: T60657

Target: TNF, MAPK

Cat.No: T61111

Target: TNF

Cat.No: T12997

Target: p38 MAPK, TNF

Cat.No: T36524

Synonym: 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide,IKK2 Inhibitor IV

Target: IκB/IKK, TNF

Cat.No: T77484

Target: TNF

Cat.No: T12781

Target: Others

Cat.No: T24816

Synonym: SP100030,SP 100030

Target: NF-κB

Cat.No: T1642

Synonym: 来那度胺,CC-5013

Target: Apoptosis, TNF, Ligand for E3 Ligase, Molecular Glues

Cat. No.	Product Name	Target	Signaling Pathways
T6S1597	Mulberroside A 桑皮苷 A,桑皮苷A	TNF; Tyrosinase; Interleukin	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	Mulberroside A 是桑中的一种主要活性成分，可降低TNF-α、IL-1β和IL-6的表达，抑制 NALP3、caspase-1 和 NF-κB 的激活以及 ERK、JNK 和 p38 的磷酸化。它抑制蘑菇酪氨酸酶，具有抗炎和抗细胞凋亡作用。
T2932	Ginsenoside Rh1 Sanchinoside B2,人参皂苷 Rh1,人参皂苷Rh1,Prosapogenin A2,20(S)-Ginsenoside Rh1,Sanchinoside Rh1	IL Receptor; TNF; Endogenous Metabolite; PPAR; Interleukin	Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism
	Ginsenoside Rh1 (Sanchinoside B2) 是人参的一种主要成分，具有抗炎作用，抑制PPAR-γ，TNF-α，IL-6和IL-1β的表达。
TN2539	1beta-Hydroxyalantolactone	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	1beta-Hydroxyalantolactone 是从药用植物大英花的花头中分离出的小分子化合物，可抑制细胞中TNF-α、IL-17、IFN-γ的表达，促进TNF-α、IFN-γ、IL-17的分泌，可防治类风湿性关节炎。
TC0036	Compound Lup-20(29)-en-3-yl acetate	IL Receptor; VEGFR; Others; TNF; COX	Angiogenesis; Apoptosis; Immunology/Inflammation; Neuroscience; Others; Tyrosine Kinase/Adaptors
	Lup-20(29)-en-3-yl acetate 是 Lupeol 的衍生物，通过下调 TNF-α、IL-1β、MCP-1、COX-2、VEGF 和颗粒酶 B 来抑制类风湿性关节炎的进展。
T2720	Ginsenoside Rc Panaxoside Rc,人参皂苷Rc,人参皂苷 Rc	Others; TNF; GABA Receptor; Interleukin	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; Others
	Ginsenoside Rc (Panaxoside Rc) 是人参中的一种人参皂苷，可抑制 TNF-α 和 IL-1β 的表达。它增强 GABA 受体 A 介导的离子通道电流。
T8288	14-Deoxyandrographolide 去氧穿心莲内酯,14-去氧穿心莲内酯	Apoptosis; Others	Apoptosis; Others
	14-Deoxyandrographolide 是穿心莲中的一种天然产物，是一种钙通道阻断剂，具有保肝功效。它通过诱导 TNFRSF1A 的释放，使肝细胞对 TNF-α 介导的凋亡脱敏。
TN1511	Cleomiscosin A	LDL; Antioxidant; TNF	Apoptosis; Metabolism; oxidation-reduction
	Cleomiscosin A 来源于 Acer okamotoanum 的叶和树枝，对小鼠腹腔巨噬细胞的 TNF-α 分泌具有抑制活性。 Cleomiscosin A 可用于预防动脉粥样硬化病变中 LDL 氧化的研究。
T0131	Cepharanthine NSC-623442,千金藤碱,千金藤素	Apoptosis; TNF; HIV Protease; Autophagy	Apoptosis; Autophagy; Microbiology/Virology; Proteases/Proteasome
	Cepharanthine (NSC-623442) 是从Stephania cepharanthaHayata 中提取的一种生物碱，具有抗炎、抗氧化作用。它可抑制肿瘤坏死因子 (TNF)-α 介导的 NFκB 刺激、质膜脂质过氧化和血小板聚集，并抑制细胞因子的产生。
T3927	Phellopterin	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Phellopterin 是一种分离自P. trifoliata 中的天然产物。它能够调节 Akt 和 PKC 通路，抑制 TNF-alpha 诱导的 VCAM-1 表达，进而减少单核细胞与内皮细胞的粘附。
TN6967	(R)-Isomucronulatol (-)-Isomucronulatol,2H-1-Benzopyran-7-ol	Apoptosis	Apoptosis
	(R)-Isomucronulatol (2H-1-Benzopyran-7-ol) 是一种可从黄芪、刺槐、虎杖和甘草叶片中提取得到的类黄酮，抑制BMSCs 在TNF-α微环境中的增殖和凋亡。(R)-Isomucronulatol 具有潜在的抗炎活性。
TN7235	4-methoxylonchocarpin	TNF; NF-κB	Apoptosis; NF-κB
	4-methoxylonchocarpin 是从Abrus precatorius 的根中分离出来的以一种有效的抗炎化合物。4-methoxylonchocarpin 通过抑制LPS 与巨噬细胞的TLR4结合来抑制NF-κB 激活TNF 表达，抑制TNBS 引起的小鼠结肠炎。
T3000	Magnolol NSC 293099,厚朴酚,5,5'-Diallyl-2,2'-biphenyldiol	NF-κB; Retinoid Receptor; Antibacterial; PPAR; p53; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; NF-κB
	Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) 是RXRα和PPARγ的激动剂，EC50值分别为 10.4 µM 和 17.7 µM。他是从厚朴的树皮中分离得到的一种木脂素。
T5754	Kavain	NF-κB; GABA Receptor	Membrane transporter/Ion channel; Neuroscience; NF-κB
	Kavain 是从卡瓦胡椒中分离出来的卡瓦酸内酯，可以正向调控GABAA 受体，具有抗焦虑作用。
T4973	Paraxanthine 1,7-二甲基黄嘌呤,1,7-DIMETHYLXANTHINE	Endogenous Metabolite	Metabolism
	Paraxanthine (1,7-dimethylxanthine) 是一种 caffeine 的代谢物，能够刺激Ryanodine 受体通道来抑制多巴胺能细胞的死亡。
T2768	Saikosaponin A 柴胡皂苷A,柴胡皂苷 A	NF-κB; Antibacterial; Liver X Receptor	Metabolism; Microbiology/Virology; NF-κB
	Saikosaponin A 是银柴胡中的主要活性成分，有抗炎活性，可上调 LXRα的表达。
T6S1256	Ruscogenin	NOS; NF-κB; NOD-like Receptor (NLR)	Immunology/Inflammation; NF-κB
	Ruscogenin 是一种重要甾体皂苷元，提取自麦冬。它能够抑制 TXNIP/NLRP3炎症体激活和 MAPK 途径，改善脑缺血诱导的血脑屏障功能障碍，具有显著抗血栓、抗炎作用。
T2823	Crocin 西红花苷,藏红花,Gardenia Yellow,Alpha-Crocin,藏红花素	Others	Others
	Crocin (Gardenia Yellow) 是从Crocus sativus 柱头中分离出的主要成分，是一种营养保健品，具有抗炎，抗癌，抗抑郁和抗惊厥等强大的药理作用。
T4904	1-Methylguanidine hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	1-Methylguanidine hydrochloride 是内源性代谢产物的一种。
T4S2063	Tetrahydrocoptisine 人血草碱,STYLOPINE	ERK; p38 MAPK; NF-κB	MAPK; NF-κB
	Tetrahydrocoptisine (STYLOPINE) 具有抑制炎症的有效作用。它通过抑制 NF-κB 信号通路对 LPS 诱导的 ALI 具有保护作用，这可能涉及抑制肺部炎症过程。它具有胃保护活性，归因于减少 NO 产生和调节促炎细胞因子，抑制中性粒细胞积累和 NF-κB 表达。它是一种活性抗炎成分，通过下调 NF-κB 活化、磷酸化 ERK1/2 和磷酸化-p38MAPK 信号通路抑制 TNF-α、IL-6 和 NO 的产生。
T6S0653	Linarin Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine,蒙花苷	TNF; AChE	Apoptosis; Neuroscience
	Linarin (Acacetin-7-O-rutinoside) 是一种选择性的乙酰胆碱酯酶 (AChE) 抑制剂，从薄荷花提取物中分离得到。
T6S1495	Ginsenoside Rk3 人参皂苷Rk3,人参皂甙 Rk3	Others; NF-κB	NF-κB; Others
	Ginsenoside Rk3 是存在于 Panax notoginseng 的根中。它能够抑制 HepG2 细胞中 TNF-α 诱导的 NF-κB 转录活性，IC50=14.24±1.30 μM。
T2S0843	Negletein 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether	IL Receptor; TNF; NOS; Interleukin	Apoptosis; Immunology/Inflammation
	Negletein (7-O-Methylbaicalein) 一种神经保护剂，可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性，其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。
T6S0139	Neobavaisoflavone	Apoptosis; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Neobavaisoflavone 是一种从Psoralea corylifolia 的种子中分离出来的类黄酮。它具有抗炎，抗癌和抗氧化的作用。它在中至高浓度下可抑制 DNA 聚合酶，也可抑制血小板聚集。
T3240	Citronellol dihydrogeraniol,香茅醇,β-香茅醇,(±)-β-Citronellol	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Citronellol ((±)-β-Citronellol) 是一种单萜类化合物，从头状天竺葵中分离到。它可通过上调 TNF-α，RIP1/RIP3 的活性，下调 caspase-3/caspase-8 的活性，以及增加活性氧 (ROS) 的聚集来诱导肿瘤细胞的坏死性凋亡。
T6S1049	Wilforine	ATPase	Membrane transporter/Ion channel
	Wilforine 是一倍半萜吡啶化合物，T. wilfordii 植物中的重要生物活性化合物，可有效治疗特发性肺纤维化。它具有抗炎和杀虫活性。
T5S0045	Isofraxidin 6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶	MMP; ERK; p38 MAPK; TLR; COX	Immunology/Inflammation; MAPK; Neuroscience; Proteases/Proteasome
	Isofraxidin (Phytodolor) 是来自刺五加的香豆素成分，抑制MMP-7表达和人肝癌细胞侵袭。它作用于肝癌细胞，抑制ERK1/2磷酸化。它减弱iNOS 和COX-2表达，还抑制TLR4/髓样分化蛋白 2 复合物的形成。
T6S1487	Ginsenoside Rg5 人参皂苷Rg5,人参皂甙 Rg5	NF-κB; COX; IGF-1R	Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors
	Ginsenoside Rg5 是红参的主要成分，可阻断IGF-1与其受体的结合，IC50约为90 nM。它还通过抑制NF-κB p65的 DNA 结合活性来抑制COX-2的 mRNA 表达。它可促进血管生成和改善高血压，具有抗炎和治疗阿尔茨海默病的潜力。
T6S1917	Schisandrol B Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B	P450; Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Schisandrol B (Besigomsin) 是华中五味子的主要活性成分，具有保肝、抗炎、抗糖尿病和抗氧化的作用。它抑制活性氧的产生，也抑制 P-糖蛋白和CYP3A 的活性。
T4S1521	1,4-Dicaffeoylquinic acid 1,4-二咖啡酰奎宁酸,洋蓟素	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	1,4-Dicaffeoylquinic acid 是一种苯丙素类物质，从苍耳子中获得，可以减少 LPS 诱导的 TNF-α 的生成，具有抗炎活性。
T2S2264	Linalool Linalol,(±)-Linalool,Phantol,沉香醇	Apoptosis; IL Receptor; TNF; Endogenous Metabolite; iGluR	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Linalool (Linalol) 是存在芫荽等植物中的单萜类天然产物，是竞争性NMDA 受体拮抗剂，具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤，具有镇痛、抗菌和抗炎的特性。
T3893	Forsythoside B 连翘酯苷 B,连翘脂苷B	TNF; NF-κB	Apoptosis; NF-κB
	Forsythoside B 是传统中药植物独一味叶子中分离的一种苯乙醇苷。它可抑制 TNF-alpha，IL-6，IκB，调节 NF-κB。它抑制炎症反应，具有抗氧化和神经保护作用。
T6S1572	Sauchinone	ERK; p38 MAPK; NF-κB	MAPK; NF-κB
	Sauchinone 是一种从Saururus chinensis 中获得的非对映异构的木脂素。它通过抑制I-κBα磷酸化和p65核易位来抑制 LPS 诱导的 iNOS，TNF-α 和 COX-2 表达。它具有抗炎和抗氧化活性。
T3673	Mollugin 大叶茜草素,Rubimaillin	HER; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Mollugin (Rubimaillin) 是Rubia cordifolia L.中主要的生物活性成分。它能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。它通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。
T60598	Thunbergol
	Thunbergol (Isocembrol) (Compound 17) 是TNF-α的有效抑制剂 (IC 50 = 7.2 μM)。
TMA0627	Taxiresinol	TNF	Apoptosis
	Taxiresinol shows anticancer, antinociceptive, and antiallergic activities, it shows inhibitory activity on induced histamine release from the human basophilic cell line, KU812. Taxiresinol can protect the hepatocytes from apoptosis via an inhibition of TNF- alpha production by activated macrophages and a direct inhibition of apoptosis induced by TNF- alpha in D-GalN/LPS-treated mice.
T12975	Sootepin D	NF-κB	NF-κB
	Sootepin D is a triterpene from the apical bud of Gardenia sootepensis, and is TNF-α-induced NF-κB inhibitor(IC50 of 8.3μM),with anti-inflammatory activity.
T13625	Coronalolic acid Coronalonic acid	NF-κB	NF-κB
	Coronalolic acid is a natural product extracted from the Gardenia sootepenesis Hutch. It inhibits TNF-α-induced NF-κB activity and NO production.
T26545	Acanthoic acid NP1302,NP 1302: NP-1302
	Acanthoic acid is a pimaradiene diterpene isolated from Acanthopanax koreanum with anti-inflammatory activities. Acanthoic acid downregulates LPS-induced IL-1β, IL-6 and TNF-α production in BALF, attenuates lung histopathologic changes, and inhibits infla
T38635	Kdo2-Lipid A ammonium	TNF; TLR; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation
	Kdo2-Lipid A ammonium (KLA）是一种具有选择性和有效性的 TLR4 激动剂，属于一种脂多糖。Kdo2-Lipid A ammonium 促使 TNF 和 PGE2 的释放。
T72799	Sinulatumolin E
	Sinulatumolin E 是一种萜类化合物，具有显着的TNF-α抑制活性，IC50值为 3.6 μM。Sinulatumolin E 具有抗炎活性。
TN2102	Procurcumenol	Others; TNF	Apoptosis; Others
	Procurcumenol is an inhibitor of Nitric Oxide. Procurcumenol and epicurcumenol have inhibitory effects on release of tumor necrosis factor-a (TNF-a).
TN2224	Soyasapogenol A 大豆甾醇A,大豆甾醇 A	TNF	Apoptosis
	Soyasapogenol A shows estrogenic and hepatoprotective activities, it directly prevents apoptosis of hepatocytes, and secondly, inhibits the elevation of plasma TNF-α±, which consequently resulted in the prevention of liver damage in the concanavalin A-induced hepatitis model.
TN5351	Cycloshizukaol A
	Cycloshizukaol A prevents monocyte adhesion to HUVEC through the inhibition of cell adhesion molecules expression stimulated by TNF-alpha, it inhibits PMA-induced homotypic aggregation of HL-60 cells without cytotoxicity with MIC values of 0.9 microM.
TN2461	Loganic acid 6′-O-β-D-glucoside 8-Epi-Loganic acid-6'-O-β-D-glucoside	Others	Others
	Loganic acid 6′-O-β-D-glucoside (8-Epi-Loganic acid-6'-O-β-D-glucoside) 是 Cistanche deserticola 的天然产物，可抑制 LPS 诱导的 NO 和 TNF-α 的产生。
TN4679	Nudiposide	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Nudiposide has significant neuroprotective activities against glutamate-injured neurotoxicity in HT22 cells. It also exhibits protective effect against sepsis in a mouse model and can decrease the plasma levels of TNF-α, IL-10 and ALT activity.
TN1228	25S-Inokosterone	TNF	Apoptosis
	25S-Inokosterone exhibits potent inhibition against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells. 25S-Inokosterone has excellent anti-atopy activity, thus 25S-Inokosterone could be used to a large range of functional anti-atopy cosmetics.
T5768	bruceine B	TNF; Parasite	Apoptosis; Microbiology/Virology
	Bruceine B 是一种有效的白细胞-内皮细胞粘附抑制剂，可抑制蛋白质和核酸合成。
TN1227	25R-Inokosterone	TNF	Apoptosis
	25R-Inokosterone exhibits potent inhibition against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells. 25R-Inokosterone has excellent anti-atopy activity, thus 25R-Inokosterone could be used to a large range of functional anti-atopy cosmetics.
T13680	Enniatin B1 恩镰孢菌素 B1	ERK	MAPK
	Enniatin B1 crosss the blood-brain barrier. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation.Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes.
T38338	Quinolactacin A
	Quinolactactin A is a quinolone fungal metabolite originally isolated from Penicillium. It inhibits TNF production induced by LPS in murine peritoneal macrophages (IC50 = 12.2 μg/ml). It is not active against a variety of bacteria, fungi, and yeasts. Quinolactacin A is a mixture of quinolactacin A1 and A2.
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天然产物

Cat.No: T6S1597

Synonym: 桑皮苷 A,桑皮苷A

Target: TNF, Tyrosinase, Interleukin

Ginsenoside Rh1

Cat.No: T2932

Synonym: Sanchinoside B2,人参皂苷 Rh1,人参皂苷Rh1,Prosapogenin A2,20(S)-Ginsenoside Rh1,Sanchinoside Rh1

Target: IL Receptor, TNF, Endogenous Metabolite, PPAR, Interleukin

1beta-Hydroxyalantolactone

Cat.No: TN2539

Target: IL Receptor, TNF

Compound Lup-20(29)-en-3-yl acetate

Cat.No: TC0036

Target: IL Receptor, VEGFR, Others, TNF, COX

Cat.No: T2720

Synonym: Panaxoside Rc,人参皂苷Rc,人参皂苷 Rc

Target: Others, TNF, GABA Receptor, Interleukin

14-Deoxyandrographolide

Cat.No: T8288

Synonym: 去氧穿心莲内酯,14-去氧穿心莲内酯

Target: Apoptosis, Others

Cat.No: TN1511

Target: LDL, Antioxidant, TNF

Cat.No: T0131

Synonym: NSC-623442,千金藤碱,千金藤素

Target: Apoptosis, TNF, HIV Protease, Autophagy

Cat.No: T3927

Target: GABA Receptor

(R)-Isomucronulatol

Cat.No: TN6967

Synonym: (-)-Isomucronulatol,2H-1-Benzopyran-7-ol

Target: Apoptosis

4-methoxylonchocarpin

Cat.No: TN7235

Target: TNF, NF-κB

Cat.No: T3000

Synonym: NSC 293099,厚朴酚,5,5'-Diallyl-2,2'-biphenyldiol

Target: NF-κB, Retinoid Receptor, Antibacterial, PPAR, p53, Autophagy

Cat.No: T5754

Target: NF-κB, GABA Receptor

Cat.No: T4973

Synonym: 1,7-二甲基黄嘌呤,1,7-DIMETHYLXANTHINE

Target: Endogenous Metabolite

Cat.No: T2768

Synonym: 柴胡皂苷A,柴胡皂苷 A

Target: NF-κB, Antibacterial, Liver X Receptor

Cat.No: T6S1256

Target: NOS, NF-κB, NOD-like Receptor (NLR)

Cat.No: T2823

Synonym: 西红花苷,藏红花,Gardenia Yellow,Alpha-Crocin,藏红花素

Target: Others

1-Methylguanidine hydrochloride

Cat.No: T4904

Target: Others, Endogenous Metabolite

Tetrahydrocoptisine

Cat.No: T4S2063

Synonym: 人血草碱,STYLOPINE

Target: ERK, p38 MAPK, NF-κB

Cat.No: T6S0653

Synonym: Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine,蒙花苷

Target: TNF, AChE

Ginsenoside Rk3

Cat.No: T6S1495

Synonym: 人参皂苷Rk3,人参皂甙 Rk3

Target: Others, NF-κB

Cat.No: T2S0843

Synonym: 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether

Target: IL Receptor, TNF, NOS, Interleukin

Neobavaisoflavone

Cat.No: T6S0139

Target: Apoptosis, DNA/RNA Synthesis

Cat.No: T3240

Synonym: dihydrogeraniol,香茅醇,β-香茅醇,(±)-β-Citronellol

Target: Reactive Oxygen Species

Cat.No: T6S1049

Target: ATPase

Cat.No: T5S0045

Synonym: 6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶

Target: MMP, ERK, p38 MAPK, TLR, COX

Ginsenoside Rg5

Cat.No: T6S1487

Synonym: 人参皂苷Rg5,人参皂甙 Rg5

Target: NF-κB, COX, IGF-1R

Cat.No: T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

1,4-Dicaffeoylquinic acid

Cat.No: T4S1521

Synonym: 1,4-二咖啡酰奎宁酸,洋蓟素

Target: HIV Protease

Cat.No: T2S2264

Synonym: Linalol,(±)-Linalool,Phantol,沉香醇

Target: Apoptosis, IL Receptor, TNF, Endogenous Metabolite, iGluR

Cat.No: T3893

Synonym: 连翘酯苷 B,连翘脂苷B

Target: TNF, NF-κB

Cat.No: T6S1572

Target: ERK, p38 MAPK, NF-κB

Cat.No: T3673

Synonym: 大叶茜草素,Rubimaillin

Target: HER, JAK

Cat.No: T60598

Cat.No: TMA0627

Target: TNF

Cat.No: T12975

Target: NF-κB

Coronalolic acid

Cat.No: T13625

Synonym: Coronalonic acid

Target: NF-κB

Cat.No: T26545

Synonym: NP1302,NP 1302: NP-1302

Kdo2-Lipid A ammonium

Cat.No: T38635

Target: TNF, TLR, Prostaglandin Receptor

Sinulatumolin E

Cat.No: T72799

Cat.No: TN2102

Target: Others, TNF

Soyasapogenol A

Cat.No: TN2224

Synonym: 大豆甾醇A,大豆甾醇 A

Target: TNF

Cycloshizukaol A

Cat.No: TN5351

Loganic acid 6′-O-β-D-glucoside

Cat.No: TN2461

Synonym: 8-Epi-Loganic acid-6'-O-β-D-glucoside

Target: Others

Cat.No: TN4679

Target: IL Receptor, TNF

25S-Inokosterone

Cat.No: TN1228

Target: TNF

Cat.No: T5768

Target: TNF, Parasite

25R-Inokosterone

Cat.No: TN1227

Target: TNF

Cat.No: T13680

Synonym: 恩镰孢菌素 B1

Target: ERK

Quinolactacin A

Cat.No: T38338

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Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00779	TNF alpha Protein, Rabbit, Recombinant TNF-a,Tumor Necrosis Factor,T...	Rabbit	E. coli
	Tumor necrosis factor alpha (TNFα) is the prototypic ligand of the TNF superfamily. TNFα forms a homotrimer and functions by activating two types of receptors TNF-R1 (TNF receptor type 1,p55R) and TNF-R2 (TNF receptor type 2,p75R). TNFα is a pleiotropic cytokine that is capable to promote inflammation, to induce apoptotic cell death, and to inhibit tumorigenesis and viral replication. TNFα is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other ...
TMPY-01294	TNF alpha Protein, Mouse, Recombinant TNF-α,Tnfsf1a,TNF-a<...	Mouse	E. coli
	TNF alpha Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.39 kDa and the accession number is P06804.
TMPJ-00137	APRIL/TNFSF13 Protein, Human, Recombinant (Flag & His) TRDL-1,TNF- and APOL-rela	Human	HEK293 Cells
	APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to release the active 17 kDa soluble molecule. Secreted human APRIL, which consists almost entirely of a single TNF homology domain, shares 85% amino acid sequence identity with mouse and rat APRIL. Both APRIL and its close relative BAFF bind and signal through the TNF superfamily recept...
TMPY-05187	TNF alpha Protein, Mouse, Recombinant, Biotinylated Tnfa,TNFSF2,肿瘤坏死因子,Tnfsf...	Mouse	E. coli
	TNF alpha Protein, Mouse, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is P06804.
TMPJ-00125	TNF alpha Protein, Human, Recombinant (aa 57-233, His) TNFA,TNF-α,Cachectin,肿瘤坏...	Human	E. coli
	TNF alpha Protein, Human, Recombinant (aa 57-233, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 18 KDa and the accession number is P01375.
TMPJ-00124	TNF alpha Protein, Human, Recombinant (aa 77-233, His) TNF-a,TNF-α,Tumor Necrosis Fa...	Human	E. coli
	TNF alpha Protein, Human, Recombinant (aa 77-233, His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 16 KDa and the accession number is P01375.
TMPJ-00288	TNF RII Protein, Human, Recombinant (mFc) Tumor necrosis factor receptor 2,TNFRSF1B,...	Human	HEK293 Cells
	TNF RII Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 60 KDa and the accession number is P20333.
TMPJ-00287	TNF RII Protein, Human, Recombinant (hFc) TNF-R2,Tumor necrosis factor receptor supe...	Human	HEK293 Cells
	TNF RII Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60-90 KDa and the accession number is P20333.
TMPJ-00546	EFNA1 Protein, Human, Recombinant (hFc) TNFAIP4,LERK1,Tumor Necrosis Fact...	Human	HEK293 Cells
	Ephrin-A1 is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. Ephrin-A1 can be induced by TNF and IL1B. Its expression levels can be down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells. Soluble Ephrin-A1 is necessary for the transformation of HeLa and SK-BR3 cells and participates in the...
TMPY-02153	TNF beta Protein, Human, Recombinant LT,TNF β,TNFSF1,肿瘤坏死因子,TNFB,lymph...	Human	E. coli
	Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1, and TNFB, is a secreted protein that belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is highly inducible, secreted, and exists as a homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR, and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRS...
TMPJ-00662	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli) Receptor activator of nuclear f	Human	E. coli
	CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitog...
TMPK-00176	BAFF/TNFSF13B Trimer Protein, Human, Recombinant (His & Flag) BLyS,TALL-1,TNFSF13B,DTL,TNFSF20,...	Human	HEK293 Cells
	B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFSF13B gene.BAFF is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFF-R. BAFF/TNFSF13B Trimer Protein, Human, Recombinant (His & Flag) is expressed in HEK293 mammalian cells with N-His-Flag tag. The predicted molecular weight is 52.4 kDa an...
TMPJ-01172	IL-17 Protein, Mouse, Recombinant (His) CTLA8,IL-17,IL-17A,Interleukin-17A	Mouse	HEK293 Cells
	Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumato...
TMPJ-00994	LTBR Protein, Mouse, Recombinant (hFc) Tnfcr,Lymphotoxin-beta receptor,Tumor necr...	Mouse	HEK293 Cells
	It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs...
TMPY-06981	IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli) interleukin 1 α,IL1,白介素,IL-1F1,IL1-α,IL-1A,IL1F1,白细...	Human	E. coli
	IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophage...
TMPK-01382	TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Recombinant (His) p75TNFR,p75TBPII,CD120b,TNF-R75,TNF	Cynomolgus	HEK293 Cells
	Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa.Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects o...
TMPJ-01312	TWEAKR/TNFRSF12A Protein, Mouse, Recombinant (hFc) Fibroblast growth factor-regulate...	Mouse	HEK293 Cells
	Tumor necrosis factor receptor superfamily member 12A(Tnfrsf12a) is a single-pass type I membrane protein and contains 1 TNFR-Cys repeat. It is weak inducer of apoptosis in some cell types.It promotes angiogenesis and it is the proliferation of endothelial cells. It may modulate cellular adhesion to matrix proteins.TNFR binds specifically to tumor necrosis factor (TNF) and blocks its interaction with cell surface TNF receptors. TNF is a naturally occurring cytokine that is involved in normal inf...
TMPK-01349	APRIL/TNFSF13 Trimer Protein, Cynomolgus, Recombinant (His & Avi, Flag) APRILFLJ57090,CD256,TRDL-1,TALL-2,TNF<...	Cynomolgus	HEK293 Cells
	The APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily.Both APRIL and its close relative BAFF bind and signal through the TNF superfamily receptors TACI and BCMA, while BAFF additionally functions through BAFFR.
TMPK-01254	BAFFR/TNFRSF13C Protein, Cynomolgus, Recombinant (His) CVID4,prolixin,TNFRSF13C,CD268,BROMIX,BAFF...	Cynomolgus	HEK293 Cells
	BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA / TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL (a proliferation-inducing ligand), BAFF R selectively binds BAFF.
TMPK-01163	APRIL/TNFSF13 Protein, Mouse, Recombinant (His & Flag) TRDL1,TALL2,TALL-2,APRILFLJ57090,...	Mouse	HEK293 Cells
	The APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily.Both APRIL and its close relative BAFF bind and signal through the TNF superfamily receptors TACI and BCMA, while BAFF additionally functions through BAFF R. APRIL/TNFSF13 Protein, Mouse, Recombinant (His & Flag) is expressed in HEK293 mammalian cells with N-His-Flag tag. The predicted molecular weight is 18.53 kDa and the accession number is Q9D777.
TMPK-00070	BAFFR/TNFRSF13C Protein, Human, Recombinant (His & Avi), Biotinylated CD268,TNFRSF13C,BAFFR,BR3,BROMIX,prolixin,...	Human	HEK293 Cells
	BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL (a proliferation-inducing ligand), BAFF R selectively binds BAFF.
TMPK-00171	TRAIL Trimer Protein, Human, Recombinant (His & Flag) TRAIL,Apo-2L,APO2L,TL2,A...	Human	HEK293 Cells
	Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can initiate the apoptosis pathway by binding to its associated death receptors DR4 and DR5. The activation of the TRAIL pathway in inducing tumor-selective apoptosis leads to the development of TRAIL-based cancer therapies, which include recombinant forms of TRAIL, TRAIL receptor agonists, and other therapeutic agents.
TMPK-00140	APRIL/TNFSF13 Trimer Protein, Human, Recombinant (His & Avi & Flag), Biotinylated APRIL,TRDL1,TALL2,TALL-2,CD256,	Human	HEK293 Cells
	The APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily.Both APRIL and its close relative BAFF bind and signal through the TNF superfamily receptors TACI and BCMA, while BAFF additionally functions through BAFF R. APRIL/TNFSF13 Trimer Protein, Human, Recombinant (His & Avi & Flag), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi and N-Flag tag. The predicted molecular weight is 52.1 kDa and the acce...
TMPK-00564	TNFR1/CD120a/TNFRSF1A Protein, Cynomolgus, Recombinant (His) TBP1,TNF-RI,TNFAR,p55,p60,p55-R,<...	Cynomolgus	HEK293 Cells
	Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2. In the setting of acute injury, selective inhibition of TNFR1 is predicted to attenuate the cell death and inflammation associated with TNF-α, while sparing or potentiating the protective effects of TNFR2 signalling.
TMPK-00142	APRIL/TNFSF13 Trimer Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated TALL-2,CD256,TRDL1,APRILFLJ57090,A	Human	HEK293 Cells
	The APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily.Both APRIL and its close relative BAFF bind and signal through the TNF superfamily receptors TACI and BCMA, while BAFF additionally functions through BAFF R. APRIL/TNFSF13 Trimer Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated is expressed in HEK293 mammalian cells with N-His-Flag tag. The predicted molecular weight is 49.9 kDa and...
TMPK-00141	APRIL/TNFSF13 Trimer Protein, Human, Recombinant (His & Flag) 2310026N09Rik,TALL-2,TNFSF13,APRI...	Human	HEK293 Cells
	The APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily.Both APRIL and its close relative BAFF bind and signal through the TNF superfamily receptors TACI and BCMA, while BAFF additionally functions through BAFF R. APRIL/TNFSF13 Trimer Protein, Human, Recombinant (His & Flag) is expressed in HEK293 mammalian cells with N-His-Flag tag. The predicted molecular weight is 49.9 kDa and the accession number is O75888-1.
TMPH-02876	RIPK1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways. Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival. Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, i...
TMPJ-01107	PAP Protein, Human, Recombinant (His) PAP1,PAP,PDGFA-Associ	Human	E. coli
	Human PAP, also known as 28 kDa heat- and acid-stable phosphoprotein, PDGF-associated protein, PDGFA-associated protein 1, PDAP1, HASPP28, is a protein which belongs to the PDAP1 family. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. PDGF-Associated Protein (PAP) is a phosphoprotein that may enhance PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB. PDAP1 expression is induced by TNF-alpha, and cells overexpressing PDAP1 sho...
TMPY-03416	TNFAIP8 Protein, Human, Recombinant (His) GG2-1,tumor necrosis factor, alpha	Human	E. coli
	Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8) family is a newly identified protein with vital roles in maintaining immune homeostasis. Tumor necrosis factor-alpha-inducible protein 8 (TNFAIP8) is a TNF-alpha inducible anti-apoptotic protein with multiple roles in tumor growth and survival. by the creation of cellular autophagy events, TNFAIP8 promotes cell survival and drug resistance in prostate cancer cells. TNFAIP8 regulates Hippo pathway through interacting with LATS1 to prom...
TMPK-00631	DR3/TNFRSF25 Protein, Mouse, Recombinant (His) TRAMP,TNFRSF12,WSL1,LARD,DR3,WSL,...	Mouse	HEK293 Cells
	TNF-like ligand 1 A (TL1A) and death receptor 3 (DR3) are a ligand-receptor pair involved in the pathogenesis of inflammatory bowel disease. Group 3 innate lymphoid cells (ILC3s) regulate intestinal immunity and highly express DR3.
TMPJ-00272	RELT/TNFRSF19L Protein, Human, Recombinant (hFc) RELT,TNFRSF19L,Receptor expressed in lymphoid tissu...	Human	HEK293 Cells
	Tumor necrosis factor receptor superfamily member 19L (TNFRSF19L), also known as Receptor expressed in lymphoid tissues and RELT, is a member of the TNF-receptor superfamily. TNFRSF19L is a single-pass type membrane protein and contains one TNFR-Cys repeat. TNFRSF19L is highly expressed in spleen, lymph node, thymus, peripheral blood leukocytes, bone marrow and fetal liver. It has been shown TNFRSF19L activates the NF-kappaB pathway and selectively binds TNF receptor-associated factor 1 (TRAF1)....
TMPJ-00168	HVEM Protein, Mouse, Recombinant (hFc) Tnfrsf14,Herpesvirus entry mediator,A<...	Mouse	HEK293 Cells
	Mouse Protein Tnfrsf14, is a type I transmembrane protein belonging to the TNF receptor superfamily. It is tumor necrosis factor receptor superfamily member 14 and expressed on the surface of T cells during the resting state. Interaction of HVEM with TNF family member LIGHT co-stimulates T cells and promotes inflammation. HVEM also triggers inhibitory signaling cascade in effector T (Teff) cells and regulatory T cells (Tregs) as a ligand of B and T lymphocyte attenuator. Tnfrsf14 is detected in ...
TMPH-02195	TXNDC17 Protein, Human, Recombinant (GST)	Human	E. coli
	Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide.
TMPK-00152	CD27/TNFRSF7 Protein, Cynomolgus, Recombinant (His) CD27 antigen,S152. LPFS2,S152,TNFRSF7,Tp55...	Cynomolgus	HEK293 Cells
	CD27, also known as TNFRSF7, is an approximately 55 kDa transmembrane protein in the TNF receptor superfamily. It functions as a co‑stimulatory molecule that supports lymphocyte activation and survival. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis.
TMPK-00130	LIGHT/TNFSF14 Trimer Protein, Human, Recombinant (His & Flag) TNFSF14, TR2,CD258,LTg,LIGHT,HVEM-L	Human	HEK293 Cells
	LIGHT, also known as tumor necrosis factor superfamily member 14 (TNFSF14), is a secreted protein of the TNF superfamily. It is recognized by herpesvirus entry mediator (HVEM), as well as decoy receptor 3.This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells.
TMPK-00122	CD30 Ligand/TNFSF8 Protein, Human, Recombinant (His) CD153,CD30LGMGC138144,CD30LG,CD30-L,CD30 Ligand,CD3...	Human	HEK293 Cells
	CD30 ligand (CD30L)/TNFSF8 is a type II membrane protein belonging to the TNF superfamily. CD30L is expressed on the cell surface of activated T cells, B cells, and monocytes. The protein is also constitutively expressed on granulocytes and medullary thymic epithelial cells.CD30L is a cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.
TMPH-01695	MLKL Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZB...
TMPJ-00968	NAMPT Protein, Human, Recombinant (His) PBEF,PBEF1,Nicotinamide phosphoribosyltran...	Human	E. coli
	Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but it is also acknowledged to be the ubiquitous intracellular enzyme nicotinamide phosphoribosyltranferase (NAMPT) and the adipokine “visfatin”. PBEF is constitutively expressed in the fetal membranes where its greatest expression is in the amnion. It has intracellular and extracellular forms. Most of the intracellular functions of PBEF are ...
TMPK-00708	TRAIL R1/DR4/TNFRSF10A Protein, Human, Recombinant (hFc) TRAIL R1,APO2,DR4,CD261,TRAIL-R,<...	Human	HEK293 Cells
	Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis selectively via its interaction with the death receptors TRAILR1/DR4 and TRAILR2/DR5 in a wide range of cancers, while sparing normal cells. Despite its tremendous potential for cancer therapeutics, the translation of TRAIL into the clinic has been confounded by TRAIL-resistant cancer populations.
TMPH-01694	MLKL Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZB...
TMPK-01203	TNFRSF19 Protein, Human, Recombinant (hFc) AW123854,TRADE,TAJ α,AL0...	Human	HEK293 Cells
	A novel susceptibility gene TNFRSF19, which encodes an orphan member of the TNF receptor superfamily known to be associated with nasopharyngeal carcinoma (NPC) and lung cancer risk. TNFRSF19, a susceptibility gene for nasopharyngeal carcinoma and other cancers, functions as a potent inhibitor of the TGFβ signaling pathway. TNFRSF19 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 42.22 kDa and the accession number is Q9NS6...
TMPK-01204	TNFRSF19 Protein, Human, Recombinant (His) Taj,TAJ-α,Toxicity and JNK induce...	Human	HEK293 Cells
	A novel susceptibility gene TNFRSF19, which encodes an orphan member of the TNF receptor superfamily known to be associated with nasopharyngeal carcinoma (NPC) and lung cancer risk. TNFRSF19, a susceptibility gene for nasopharyngeal carcinoma and other cancers, functions as a potent inhibitor of the TGFβ signaling pathway. TNFRSF19 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 16.55 kDa and the accession number is Q9NS6...
TMPK-00276	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi) ZTNFR9,DR5TRICK2B,DR5,TRAIL receptor 2,TRI...	Human	HEK293 Cells
	DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
TMPK-00489	TL1A/TNFSF15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) TNFSF15,TNF superfamily member 15...	Cynomolgus,Rhesus	HEK293 Cells
	TNF superfamily member 15 (TNFSF15), a cytokine largely produced by vascular endothelial cells and a specific inhibitor of the proliferation of these same cells, can inhibit VEGF-induced vascular permeability in vitro and in vivo, and that death receptor 3 (DR3), a cell surface receptor of TNFSF15, mediates TNFSF15-induced dephosphorylation of VEGFR2. TNFSF15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weigh...
TMPK-00064	BCMA/TNFRSF17 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) TNFRSF13A,BCMA,TNFRSF17,...	Cynomolgus,Rhesus	HEK293 Cells
	B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene.TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF). BCMA/TNFRSF17 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 7.10 kDa and the accession number is A0A2K5UD...
TMPK-00072	BCMA/TNFRSF17 Protein, Mouse, Recombinant (His & Avi), Biotinylated TNFRSF13A,TNFRSF17,BCM,BCMA	Mouse	HEK293 Cells
	B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene.TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF). BCMA/TNFRSF17 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 8.5 kDa and the accession number is O8847...
TMPH-02770	TNF beta Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo. TNF beta Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.8 kDa and the accession number is P09225.
TMPJ-00066	BCMA/TNFRSF17 Protein, Human, Recombinant (His & Flag) Tumor necrosis factor receptor superfamily...	Human	HEK293 Cells
	B cell maturation antigen (BCMA) is a member of the TNF receptor superfamily. It has been designated TNFRSF17. Mouse BCMA is a 185 amino acid (aa) protein consisting of a 49 aa extracellular domain, a 23 aa transmembrane domain, and a 113 aa intracellular domain. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand ...
TMPH-02650	FCMR/FAIM3 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
TMPK-00071	BCMA/TNFRSF17 Protein, Mouse, Recombinant (His & Avi) TNFRSF17,BCMA,BCM,TNFRSF13A	Mouse	HEK293 Cells
	B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene.TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF). BCMA/TNFRSF17 Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 8.5 kDa and the accession number is O88472-1.
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重组蛋白

TNF alpha Protein, Rabbit, Recombinant

Cat.No: TMPJ-00779

Species: Rabbit

Expression System: E. coli

TNF alpha Protein, Mouse, Recombinant

Cat.No: TMPY-01294

Species: Mouse

Expression System: E. coli

APRIL/TNFSF13 Protein, Human, Recombinant (Flag & His)

Cat.No: TMPJ-00137

Species: Human

Expression System: HEK293 Cells

TNF alpha Protein, Mouse, Recombinant, Biotinylated

Cat.No: TMPY-05187

Species: Mouse

Expression System: E. coli

TNF alpha Protein, Human, Recombinant (aa 57-233, His)

Cat.No: TMPJ-00125

Species: Human

Expression System: E. coli

TNF alpha Protein, Human, Recombinant (aa 77-233, His)

Cat.No: TMPJ-00124

Species: Human

Expression System: E. coli

TNF RII Protein, Human, Recombinant (mFc)

Cat.No: TMPJ-00288

Species: Human

Expression System: HEK293 Cells

TNF RII Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00287

Species: Human

Expression System: HEK293 Cells

EFNA1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00546

Species: Human

Expression System: HEK293 Cells

TNF beta Protein, Human, Recombinant

Cat.No: TMPY-02153

Species: Human

Expression System: E. coli

RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)

Cat.No: TMPJ-00662

Species: Human

Expression System: E. coli

BAFF/TNFSF13B Trimer Protein, Human, Recombinant (His & Flag)

Cat.No: TMPK-00176

Species: Human

Expression System: HEK293 Cells

IL-17 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01172

Species: Mouse

Expression System: HEK293 Cells

LTBR Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00994

Species: Mouse

Expression System: HEK293 Cells

IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)

Cat.No: TMPY-06981

Species: Human

Expression System: E. coli

TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01382

Species: Cynomolgus

Expression System: HEK293 Cells

TWEAKR/TNFRSF12A Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-01312

Species: Mouse

Expression System: HEK293 Cells

APRIL/TNFSF13 Trimer Protein, Cynomolgus, Recombinant (His & Avi, Flag)

Cat.No: TMPK-01349

Species: Cynomolgus

Expression System: HEK293 Cells

BAFFR/TNFRSF13C Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01254

Species: Cynomolgus

Expression System: HEK293 Cells

APRIL/TNFSF13 Protein, Mouse, Recombinant (His & Flag)

Cat.No: TMPK-01163

Species: Mouse

Expression System: HEK293 Cells

BAFFR/TNFRSF13C Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00070

Species: Human

Expression System: HEK293 Cells

TRAIL Trimer Protein, Human, Recombinant (His & Flag)

Cat.No: TMPK-00171

Species: Human

Expression System: HEK293 Cells

APRIL/TNFSF13 Trimer Protein, Human, Recombinant (His & Avi & Flag), Biotinylated

Cat.No: TMPK-00140

Species: Human

Expression System: HEK293 Cells

TNFR1/CD120a/TNFRSF1A Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00564

Species: Cynomolgus

Expression System: HEK293 Cells

APRIL/TNFSF13 Trimer Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated

Cat.No: TMPK-00142

Species: Human

Expression System: HEK293 Cells

APRIL/TNFSF13 Trimer Protein, Human, Recombinant (His & Flag)

Cat.No: TMPK-00141

Species: Human

Expression System: HEK293 Cells

RIPK1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02876

Species: Mouse

Expression System: E. coli

PAP Protein, Human, Recombinant (His)

Cat.No: TMPJ-01107

Species: Human

Expression System: E. coli

TNFAIP8 Protein, Human, Recombinant (His)

Cat.No: TMPY-03416

Species: Human

Expression System: E. coli

DR3/TNFRSF25 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00631

Species: Mouse

Expression System: HEK293 Cells

RELT/TNFRSF19L Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00272

Species: Human

Expression System: HEK293 Cells

HVEM Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00168

Species: Mouse

Expression System: HEK293 Cells

TXNDC17 Protein, Human, Recombinant (GST)

Cat.No: TMPH-02195

Species: Human

Expression System: E. coli

CD27/TNFRSF7 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00152

Species: Cynomolgus

Expression System: HEK293 Cells

LIGHT/TNFSF14 Trimer Protein, Human, Recombinant (His & Flag)

Cat.No: TMPK-00130

Species: Human

Expression System: HEK293 Cells

CD30 Ligand/TNFSF8 Protein, Human, Recombinant (His)

Cat.No: TMPK-00122

Species: Human

Expression System: HEK293 Cells

MLKL Protein, Human, Recombinant (His)

Cat.No: TMPH-01695

Species: Human

Expression System: P. pastoris (Yeast)

NAMPT Protein, Human, Recombinant (His)

Cat.No: TMPJ-00968

Species: Human

Expression System: E. coli

TRAIL R1/DR4/TNFRSF10A Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00708

Species: Human

Expression System: HEK293 Cells

MLKL Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-01694

Species: Human

Expression System: E. coli

TNFRSF19 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-01203

Species: Human

Expression System: HEK293 Cells

TNFRSF19 Protein, Human, Recombinant (His)

Cat.No: TMPK-01204

Species: Human

Expression System: HEK293 Cells

TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00276

Species: Human

Expression System: HEK293 Cells

TL1A/TNFSF15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)

Cat.No: TMPK-00489

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

BCMA/TNFRSF17 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)

Cat.No: TMPK-00064

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

BCMA/TNFRSF17 Protein, Mouse, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00072

Species: Mouse

Expression System: HEK293 Cells

TNF beta Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02770

Species: Mouse

Expression System: E. coli

BCMA/TNFRSF17 Protein, Human, Recombinant (His & Flag)

Cat.No: TMPJ-00066

Species: Human

Expression System: HEK293 Cells

FCMR/FAIM3 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02650

Species: Mouse

Expression System: E. coli

BCMA/TNFRSF17 Protein, Mouse, Recombinant (His & Avi)

Cat.No: TMPK-00071

Species: Mouse

Expression System: HEK293 Cells

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