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Search Results for " antiangiogenic "

77

抑制剂 & 化合物

17

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T79364	Antiangiogenic agent 4	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Antiangiogenic agent 4（Compound 3b）在HFF和HUVEC细胞中抑制Akt磷酸化，可应用于癌症研究。
T72363	Antiangiogenic agent 3
	Antiangiogenic agent 3 是一种抗血管生成剂，具有抑制人脐静脉内皮细胞(HUVEC)生长、迁移与趋化运动的作用。此外，该化合物还能降低 Src、cdc42 以及 MAPK 的基因表达。
T62931	Antiangiogenic agent 2
	Antiangiogenic agent 2 (compound 3b) 是一种有效的胸苷磷酸化酶 (thymidine phosphorylase) 抑制剂 (IC50: 39.71 μM)，表现出抗血管生成作用。
T21593	AAL-993	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	AAL-993 是口服有效的VEGFR 选择性抑制剂，抑制 VEGFR1、VEGFR2 和 VEGFR3 的IC50分别为 130 nM、23 nM 和 18 nM，对其他酪氨酸激酶的抑制作用较弱。AAL-993 具有抗血管生成和抗肿瘤的活性。
T6027	Delanzomib 德兰佐米,CEP-18770	Apoptosis; NF-κB; Proteasome	Apoptosis; NF-κB; Proteases/Proteasome; Ubiquitination
	Delanzomib (CEP-18770) 是一种强效的具有口服活性的蛋白酶体的胰凝乳蛋白酶样活性抑制剂，IC50为 3.8 nM。它抑制NF-κB 活性，诱导癌细胞凋亡，具有很强的抗血管生成和抗癌活性。
T8742	G5-7 JAK2 inhibitor G5-7	Apoptosis; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK2 inhibitor G5-7 (JAK2 inhibitor G5-7) 是具有口服活性的JAK2变构抑制剂，可通过结合到 JAK2，选择性的抑制JAK2介导的 EGFR 和 STAT3 的磷酸化和激活。它诱导细胞周阻滞和诱导凋亡、具有抗血管生成活性。它有用于胶质瘤研究的潜能。
T29797	AKB-6899 AKB6899	VEGFR; HIF/HIF Prolyl-Hydroxylase; HIF	Angiogenesis; Chromatin/Epigenetic; Metabolism; Tyrosine Kinase/Adaptors
	AKB-6899 是脯氨酰羟化酶结构域 3 (PHD3) 的抑制剂，可增加 GM-CSF 处理的巨噬细胞产生的 VEGF 受体的可溶形式 (sVEGFR-1)。 AKB-6899 能稳定 HIF-2α，从而诱导肿瘤相关巨噬细胞产生 sVEGFR-1 并减少肿瘤生长。
T1792L	Regorafenib monohydrate	Raf; VEGFR; c-RET; PDGFR; c-Kit; Autophagy	Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors
	Regorafenib monohydrate 是一种新型口服多激酶抑制剂，对VEGFR1/2/3、PDGFRβ、Kit、RET 和Raf-1的IC50分别为 13、4.2、46、22、7、1.5 和 2.5 nM。
T3289	Amifostine 氨磷汀,Ethyol,WR2721,Gammaphos	Others; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism; Others
	Amifostine (Ethyol) 是一种广谱细胞保护剂和辐射防护剂，具有清除自由基的作用。它可选择性保护正常组织免受放射线和化学疗法造成的损害。它是有效的 HIF-α1和 p53诱导剂，可降低肾脏毒性并具有抗血管生成作用。
T21334	Bucillamine DE-019,Thiobutarit,Tiobutarit,布西拉明,SA96,DE 019,DE019	VEGFR; Antioxidant	Angiogenesis; oxidation-reduction; Tyrosine Kinase/Adaptors
	Bucillamine (DE019) 可防止高危器官移植中的缺血/再灌注损伤，抑制 VEGF 的产生。 Bucillamine 是一种具有抗风湿和抗血管生成特性的口服活性巯基供体和抗氧化剂。 Bucillamine 可用于脉络膜新生血管和类风湿性关节炎的研究。
T41003	KG5	Raf; FLT; PDGFR; c-Kit	Angiogenesis; MAPK; Tyrosine Kinase/Adaptors
	KG5 是 PDGFRβ 和 B-Raf 的双重变构抑制剂，对 PDGFRβ 和 PDGFRα 的 Kd 分别为 520 nM 和 300 nM。 KG5 抑制 FLT3、KIT 和 c-Raf，具有抗癌和抗血管生成活性。
T6381	Amifostine trihydrate Ethyol trihydrate,WR2721,三水氨磷汀,Amifostine	Others; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism; Others
	Amifostine trihydrate (WR2721) 是一种广谱细胞保护剂和辐射防护剂。它可选择性保护正常组织免受放射线和化学疗法造成的损害。它是有效的HIF-α1和p53诱导剂。它通过清除氧衍生的自由基来保护细胞免受损伤。它可降低肾脏毒性并具有抗血管生成作用。
T2586	Cabozantinib 卡博替尼,XL184,BMS-907351	Apoptosis; VEGFR; FLT; c-Met/HGFR; c-RET; TAM Receptor; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Cabozantinib (XL184) 是一种多靶点酪氨酸激酶受体抑制剂，可以抑制 VEGFR2、c-Met、Kit、Axl 和 Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM)。Cabozantinib 具有抗肿瘤和抗血管生成活性。
T1792	Regorafenib BAY 73-4506,瑞戈非尼,Fluoro-Sorafenib,瑞格非尼	Raf; VEGFR; c-RET; PDGFR; c-Kit; Autophagy	Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors
	Regorafenib (BAY 73-4506) 是一种多靶点受体酪氨酸激酶抑制剂，抑制 RET、C-RAF、VEGFR2、c-Kit、VEGFR1 和 PDGFRβ (IC50=1.5/2.5/4.2/7/13/22 nM)，具有口服活性。Regorafenib 具有抗肿瘤和抗血管生成活性。
T5164	Cabozantinib hydrochloride XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351,盐酸卡博替尼	VEGFR; FLT; c-Met/HGFR; TAM Receptor; c-Kit; ROR	Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
	Cabozantinib hydrochloride (XL184) 是一种有效的泛酪氨酸激酶抑制剂，可抑制 VEGFR2、c-Met、Kit、Axl 和 Flt4（IC50：0.035、1.3、4.6、7 和 6 nM）。
T21746	Terameprocol tetramethyl Nordihydroguaiaretic Acid,EM-1421	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Terameprocol (EM-1421) 是 Nordihydroguaiaretic acid 的合成衍生物，是非选择性脂氧合酶抑制剂。
T73368	UniPR505	Ephrin Receptor	Tyrosine Kinase/Adaptors
	UniPR505 是一种有效的 EphA2 拮抗剂（IC50：0.95 µM），是一种具有抗血管生成作用的新型 3α-氨基甲酰氧基衍生物。
T16545	Pivanex Pivalyloxymethyl butyrate,AN-9	Apoptosis; HDAC; Bcr-Abl	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Tyrosine Kinase/Adaptors
	Pivanex (Pivalyloxymethyl butyrate) 是丁酸的一种衍生物，是具有口服活性的 HDAC 抑制剂。Pivanex 通过下调 bcr-abl 蛋白增强凋亡。Pivanex 显示出抗转移和抗血管生成的活性。
T2644	(E)-Daporinad Daporinad,(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE,APO866,FK866,达珀利奈	NAMPT; Transferase; Autophagy	Autophagy; Metabolism
	(E)-Daporinad (FK866) 是一种烟酰胺磷酸核糖基转移酶的小分子抑制剂，具有潜在的抗肿瘤和抗血管生成活性，IC50为 0.09 nM。
T1996	Defactinib PF-04554878,VS-6063	FAK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Defactinib (VS-6063) 是新型的 FAK 抑制剂，能够时间和剂量依赖性的抑制 FAK 在 Tyr397 位点磷酸化。
T19668	Tiomolibdate diammonium Ammonium molybdenum sulfide,Ammonium tetrathiomolybdate,NSC 286644,ATTM,四硫钼酸铵,Coprexa	Others	Others
	Tiomolibdate diammonium (NSC-286644) 是超氧化物歧化酶 1 (SOD1) 的抑制剂，具有抗血管生成和抗肿瘤活性。 Tiomolibdate diammonium 抑制铜酶的活性，包括 SOD1 和 COX。
T2577	Dienogest 地诺孕素,STS 557	Apoptosis; Estrogen/progestogen Receptor; Progesterone Receptor; Autophagy	Apoptosis; Autophagy; Endocrinology/Hormones; Others
	Dienogest (STS 557) 是一种孕酮受体激动剂，作用于子宫内膜异位，有口服的子宫内膜活性。
T2456	Tivozanib 替沃扎尼,AV-951,KRN951	VEGFR; PDGFR; Ephrin Receptor	Angiogenesis; Tyrosine Kinase/Adaptors
	Tivozanib (KRN951) 是一种选择性的 VEGFR 1/2/3抑制剂，它们的 IC50值分别为0.21 nM、0.16 nM、0.24 nM。
T6091	CP-673451	VEGFR; PDGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	CP673451 是选择性的血小板源生长因子受体 (PDGFR) 抑制剂，能够抑制 PDGFRα (IC50:10 nM) 和 PDGFRβ (IC50:1 nM) 的活性。
T16380	OGT 2115	Others	Others
	OGT 2115是一种肝素酶(IC50 = 0.4µM)抑制剂，肝素酶是一种将硫酸肝素分解成葡萄糖醛酸(GlcUA)和 n -乙酰氨基葡萄糖(GlcNAc)的酶。同时，OGT 2115也具有抗血管生成性能(IC50=1 μM)。
T13178	Toceranib 托西尼布,PHA 291639E,SU11654	VEGFR; PDGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Toceranib (PHA 291639E) 是口服具有活力的受体酪氨酸激酶 (RTK) 抑制剂，能有效抑制PDGFR，VEGFR，Kit，抑制 PDGFRβ 和 Flk-1/KDR 的Ki 分别为 5 nM 和 6 nM。它具有抗肿瘤和抗血管生成作用，用于研究犬肥大细胞肿瘤。
T1178	Temozolomide NSC 362856,替莫唑胺,TZM,CCRG 81045,TMZ	Apoptosis; DNA Alkylator/Crosslinker; DNA/RNA Synthesis; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Temozolomide (TMZ) 是一种 DNA 烷基化剂，具有血脑屏障渗透性和口服活性。Temozolomide 具有抗肿瘤活性和抗血管生成活性，还可以诱导细胞凋亡和自噬。
T76941	Carotuximab DE-122,TRC105	TGF-beta/Smad; Immunology/Inflammation related	Immunology/Inflammation; Stem Cells
	Carotuximab（DE-122）是一种新型内胆苷抗体，具有强大的抗血管生成活性和抗炎活性。Carotuximab 可阻断内皮糖蛋白 (CD105) 及其下游 Smad 信号通路。Carotuximab 具有免疫调节和抗肿瘤作用，可预防高胆固醇血症和高血糖诱导的人内皮功能障碍。
T1608	ADH-1 trifluoroacetate Exherin trifluoroacetate	Dehydrogenase	Metabolism
	ADH-1 trifluoroacetate (Exherin trifluoroacetate) 是一种选择性的、竞争性N-钙粘蛋白拮抗剂，具有潜在抗肿瘤和抗血管生成作用。
T15616	JNJ-10198409 3-氟-N-(6,7-二甲氧基-2,4-二氢茚并[1,2-C〕吡唑-3-基苯基胺,JNJ-10198409	PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	JNJ-10198409 是相对选择性的、ATP 竞争性的、具有口服活性的血小板衍生生长因子受体酪氨酸激酶抑制剂，其IC50=2 nM。它对PDGFR-β激酶 (IC50=4.2 nM) 和PDGFR-α激酶 (IC50=45 nM) 有较好的抑制作用。它是双重机制的抗血管生成和肿瘤细胞的抗增殖剂。
T10883L	CRA-026440 hydrochloride CRA-026440 hydrochloride（847460-34-8 Free base）	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	CRA-026440 hydrochloride 是有效的、广谱的 HDAC 抑制剂。CRA-026440 hydrochloride 作用于 HDAC1，HDAC2，HDAC3，HDAC6，HDAC8 和 HDAC10， Ki 值分别为 4 nM，14 nM，11 nM，15 nM，7 nM 和 20 nM。CRA-026440 hydrochloride 具有抗血管生成和抗肿瘤活性。
T15181	DuP-697	COX	Immunology/Inflammation; Neuroscience
	DuP-697 是一种不可逆的特异性 COX-2 抑制剂，对人 COX-2 和 COX-1 的 IC50 值为 10 nM 和 800 nM。 DuP-697 具有抗增殖活性，IC50 为 42.8 nM。 DuP-697 具有抗血管生成、抗炎、解热和凋亡作用。
T6695	Tasquinimod 他喹莫德,ABR-215050	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Tasquinimod (ABR-215050) 是一种口服抗血管生成剂，有潜在的抗肿瘤活性。它也是 S100A9抑制剂，与 HDAC4Zn2+结合结构域结合的 Kd 值在10到30 nM 之间。
T14871	Carboxyamidotriazole Orotate L-651582 Orotate,CAI Orotate	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Carboxyamidotriazole Orotate (L-651582 Orotate) 是一种可口服的信号转导抑制剂，是Carboxyamidotriazole (CAI) 的乳清酸盐形式。它是一种非电压性钙通道和钙通道介导的信号通路的细胞抑制剂，具有抗癌、抗炎活性和抗血管生成作用。
T22443	Triglycidyl isocyanurate Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,1,3,5-三缩水甘油-S-三嗪三酮,TGI	Apoptosis	Apoptosis
	Triglycidyl isocyanurate (Teroxirone) 是一种三氮烯三环氧化合物，可通过 p53的激活抑制非小细胞肺癌细胞的生长。它诱导细胞凋亡，具有抗血管生成和抗肿瘤活性，用于癌症研究。
T26047	Razoxane, (R)- ICRF-186,ICRF186,NSC-169779,ICRF 186,NSC 169779
	Razoxane, (R)- shows antiangiogenic effects.
T70724	GSK-2256098 HCl
	GSK-2256098 HCl is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities.
T71208	GO-Y078
	GO-Y078 is an antiangiogenic curcumin analog which inhibits actin stress fiber formation, thereby resulting in mobility inhibition.
T25290	DAT1 DAT-1,DAT 1
	DAT1 is an antimitotic and antiangiogenic that acts by binding to the colchicine binding site of tubulin.
T2358L	ENMD-2076 tartrate ENMD-2076,L-(+) Tartrate salt of ENMD-981693,ENMD2076,ENMD 2076
	ENMD-2076 is an orally active kinase inhibitor. It also has antiangiogenic and antiproliferative mechanisms of action.
T70609	Bisnafide mesylate
	Bisnafide is a Naphthalimide Analogue that acts as DNA intercalator and topo II inhibitor. It is also an antiangiogenic agent. Antiangiogenic agents can normalize tumor vessels and promote the delivery of cytotoxic agents to tumor sites.
T28348	PD 404182 PD404182,PD-404182
	PD-404182, an inhibitor of KDO 8-P synthase (Ki = 26 nM), is a otential antibiotic of gram negative bacteria. PD-404182 also exhibits antiviral and antiangiogenic activity in vitro.
T37377	Aminohexylgeldanamycin
	Aminohexylgeldanamycin (AHGDM), a derivative of Geldanamycin, is a highly effective inhibitor of HSP90. It exhibits considerable antiangiogenic and antitumor properties[1].
T38522	Aminohexylgeldanamycin hydrochloride AHGDM hydrochloride,Aminohexylgeldanamycin hydrochloride
	Aminohexylgeldanamycin (AHGDM) hydrochloride is a Geldanamycin derivative and a powerful inhibitor of HSP90. It exhibits significant antiangiogenic and antitumor properties.
T14872	Carboxyamidotriazole CAI,L-651582	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Carboxyamidotriazole is a cytostatic inhibitor of non-voltage-operated calcium channels and calcium channel-mediated signaling pathways. It shows anti-inflammatory, anti-tumor, and antiangiogenic effects.
T71488	Cremastranone
	Cremastranone is a natural antiangiogenic homoisoflavanone. Cremastranone inhibits the proliferation, migration, and tube formation ability of human retinal microvascular endothelial cells.
T15234	ENMD-1198 IRC 110160,ENMD-119,ENMD 1198	HIF; STAT	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.
T24657	YLT192 YLT 192,YLT-192
	YLT192 is an orally active and bioavailable VEGFR2 inhibitor. It also has potent antiangiogenic activity and antitumor efficacy.
TP1879	HSDVHK-NH2 P11
	Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.
T11930	M8891	Others	Others
	M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor(IC50 :54nM;Ki:4.33 nM).M8891 inhibits growth of primary endothelial cells as well as tumor cells and demonstrates antiangiogenic and antitumoral acti

化合物

Antiangiogenic agent 4

Cat.No: T79364

Target: Akt

Antiangiogenic agent 3

Cat.No: T72363

Antiangiogenic agent 2

Cat.No: T62931

Cat.No: T21593

Target: VEGFR

Cat.No: T6027

Synonym: 德兰佐米,CEP-18770

Target: Apoptosis, NF-κB, Proteasome

Cat.No: T8742

Synonym: JAK2 inhibitor G5-7

Target: Apoptosis, JAK

Cat.No: T29797

Synonym: AKB6899

Target: VEGFR, HIF/HIF Prolyl-Hydroxylase, HIF

Regorafenib monohydrate

Cat.No: T1792L

Target: Raf, VEGFR, c-RET, PDGFR, c-Kit, Autophagy

Cat.No: T3289

Synonym: 氨磷汀,Ethyol,WR2721,Gammaphos

Target: Others, HIF/HIF Prolyl-Hydroxylase

Cat.No: T21334

Synonym: DE-019,Thiobutarit,Tiobutarit,布西拉明,SA96,DE 019,DE019

Target: VEGFR, Antioxidant

Cat.No: T41003

Target: Raf, FLT, PDGFR, c-Kit

Amifostine trihydrate

Cat.No: T6381

Synonym: Ethyol trihydrate,WR2721,三水氨磷汀,Amifostine

Target: Others, HIF/HIF Prolyl-Hydroxylase

Cat.No: T2586

Synonym: 卡博替尼,XL184,BMS-907351

Target: Apoptosis, VEGFR, FLT, c-Met/HGFR, c-RET, TAM Receptor, c-Kit

Cat.No: T1792

Synonym: BAY 73-4506,瑞戈非尼,Fluoro-Sorafenib,瑞格非尼

Target: Raf, VEGFR, c-RET, PDGFR, c-Kit, Autophagy

Cabozantinib hydrochloride

Cat.No: T5164

Synonym: XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351,盐酸卡博替尼

Target: VEGFR, FLT, c-Met/HGFR, TAM Receptor, c-Kit, ROR

Cat.No: T21746

Synonym: tetramethyl Nordihydroguaiaretic Acid,EM-1421

Target: HIV Protease

Cat.No: T73368

Target: Ephrin Receptor

Cat.No: T16545

Synonym: Pivalyloxymethyl butyrate,AN-9

Target: Apoptosis, HDAC, Bcr-Abl

Cat.No: T2644

Synonym: Daporinad,(E)-N-[4-(1-BENZOYL-PIPERIDIN-4-YL)-BUTYL]-3-PYRIDIN-3-YL-ACRYLAMIDE,APO866,FK866,达珀利奈

Target: NAMPT, Transferase, Autophagy

Cat.No: T1996

Synonym: PF-04554878,VS-6063

Target: FAK

Tiomolibdate diammonium

Cat.No: T19668

Synonym: Ammonium molybdenum sulfide,Ammonium tetrathiomolybdate,NSC 286644,ATTM,四硫钼酸铵,Coprexa

Target: Others

Cat.No: T2577

Synonym: 地诺孕素,STS 557

Target: Apoptosis, Estrogen/progestogen Receptor, Progesterone Receptor, Autophagy

Cat.No: T2456

Synonym: 替沃扎尼,AV-951,KRN951

Target: VEGFR, PDGFR, Ephrin Receptor

Cat.No: T6091

Target: VEGFR, PDGFR, c-Kit

Cat.No: T16380

Target: Others

Cat.No: T13178

Synonym: 托西尼布,PHA 291639E,SU11654

Target: VEGFR, PDGFR, c-Kit

Cat.No: T1178

Synonym: NSC 362856,替莫唑胺,TZM,CCRG 81045,TMZ

Target: Apoptosis, DNA Alkylator/Crosslinker, DNA/RNA Synthesis, Autophagy

Cat.No: T76941

Synonym: DE-122,TRC105

Target: TGF-beta/Smad, Immunology/Inflammation related

ADH-1 trifluoroacetate

Cat.No: T1608

Synonym: Exherin trifluoroacetate

Target: Dehydrogenase

Cat.No: T15616

Synonym: 3-氟-N-(6,7-二甲氧基-2,4-二氢茚并[1,2-C〕吡唑-3-基苯基胺,JNJ-10198409

Target: PDGFR

CRA-026440 hydrochloride

Cat.No: T10883L

Synonym: CRA-026440 hydrochloride（847460-34-8 Free base）

Target: HDAC

Cat.No: T15181

Target: COX

Cat.No: T6695

Synonym: 他喹莫德,ABR-215050

Target: HDAC

Carboxyamidotriazole Orotate

Cat.No: T14871

Synonym: L-651582 Orotate,CAI Orotate

Target: Calcium Channel

Triglycidyl isocyanurate

Cat.No: T22443

Synonym: Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,1,3,5-三缩水甘油-S-三嗪三酮,TGI

Target: Apoptosis

Cat.No: T26047

Synonym: ICRF-186,ICRF186,NSC-169779,ICRF 186,NSC 169779

GSK-2256098 HCl

Cat.No: T70724

Cat.No: T71208

Cat.No: T25290

Synonym: DAT-1,DAT 1

ENMD-2076 tartrate

Cat.No: T2358L

Synonym: ENMD-2076,L-(+) Tartrate salt of ENMD-981693,ENMD2076,ENMD 2076

Bisnafide mesylate

Cat.No: T70609

Cat.No: T28348

Synonym: PD404182,PD-404182

Aminohexylgeldanamycin

Cat.No: T37377

Aminohexylgeldanamycin hydrochloride

Cat.No: T38522

Synonym: AHGDM hydrochloride,Aminohexylgeldanamycin hydrochloride

Carboxyamidotriazole

Cat.No: T14872

Synonym: CAI,L-651582

Target: Calcium Channel

Cat.No: T71488

Cat.No: T15234

Synonym: IRC 110160,ENMD-119,ENMD 1198

Target: HIF, STAT

Cat.No: T24657

Synonym: YLT 192,YLT-192

Cat.No: TP1879

Synonym: P11

Cat.No: T11930

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1112	Morellic acid	Others	Others
	Morellic acid 提取于 Garcinia Morella 中，具有抗血管生成作用。
T3776	Rhapontigenin 丹叶大黄素,Protigenin	P450; Antibacterial; Antifungal	Metabolism; Microbiology/Virology
	Rhapontigenin (Protigenin) 是一种基于机制的选择性细胞色素 P450 1A1 (IC50: 400 nM) 灭活剂。它是一种芳烃羟化酶，可激活作为致癌物质的多环芳烃。它是白藜芦醇的天然类似物，具有抗癌，抗氧化剂，抗真菌和抗菌活性。
T1335	Mycophenolic acid 霉酚酸,Mycophenolate,RS-61443	Apoptosis; Dehydrogenase; Endogenous Metabolite; Antibacterial; Antibiotic; UGT; Antifungal	Apoptosis; Metabolism; Microbiology/Virology
	Mycophenolic acid (Mycophenolate) 是一种有效的非竞争性肌苷单磷酸脱氢酶 (IMPDH) 抑制剂，EC50为 0.24 µM。它对多种 RNA 病毒具有抗病毒作用。它也是一种免疫抑制剂，具有抗血管生成和抗肿瘤作用。
T1011	Itraconazole 伊曲康唑,R51211	P450; Hedgehog/Smoothened; Antibiotic; Autophagy; Antifungal	Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Stem Cells
	Itraconazole (R51211) 是三唑类抗真菌药，也是口服活性的Hedgehog 信号通路拮抗剂，IC50约为 800 nM。它也是 oxysterol-binding protein 抑制剂。它抑制羊毛甾醇 14α-脱甲基酶，从而抑制羊毛甾醇向麦角固醇的氧化转化。它有抗癌和抗血管作用。
T3S2027	Rubusoside	Others	Others
	Rubusoside 是天然的增溶剂及甜味剂，具有良好的抗血管新生和抗过敏药的特性。
T3878	Raddeanin A NSC382873,竹节香附素A,Anemodeanin A,Raddeanin R3	Apoptosis; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Raddeanin A (NSC-382873) 是竹节香附中的一种天然三萜皂苷，可抑制组蛋白去乙酰化酶，具有很强的抗血管生成能力和抗肿瘤活性。
T4S0999	(2S)-Isoxanthohumol Isoxanthohumol,(2S)-异黄腐酚,异黄腐醇	Virus Protease; HSV	Microbiology/Virology
	(2S)-Isoxanthohumol 是一种由啤酒花原异戊烯基二氢黄酮 Isoxanthohumol 的微生物转化代谢物。
T3864	Erianin	BCL; Antibacterial	Apoptosis; Microbiology/Virology
	Erianin 能抑制吲哚胺-2,3-双加氧酶诱导的肿瘤血管生成，可用作退烧药和止疼剂。
T7032	Eupatorin	Others; P450	Metabolism; Others
	Eupatorin 是天然存在的黄酮，可捕获 G2-M 细胞周期，激活多个 caspase、细胞色素 C 的释放、多聚 (ADP-核糖) 聚合酶的裂解，促使凋亡细胞死亡。
T2S0886	Terrestrosin D	Apoptosis; Others	Apoptosis; Others
	Terrestrosin D 是从刺蒺藜中提取得到一种的甾体皂苷，可诱导细胞周期阻滞和癌细胞凋亡，具有抗血管生成的活性。
TN1236	3',4',7-Trihydroxyisoflavone	MAPK; JNK	MAPK
	3',4',7-Trihydroxyisoflavone 是大豆异黄酮大豆苷元衍生物，是 Cot (Tpl2/MAP3K8) 和 MKK4 抑制剂，具有抗癌、抗血管生成和自由基清除特性。3',4',7-Trihydroxyisoflavone 通过调节小鼠胆碱能功能和BDNF信号通路增强记忆作用，可改善因内源性或外源性糖皮质激素而受损的皮肤屏障功能，可用于研究特应性皮炎。
T5S2343	Acetylshikonin 乙酰紫草素,Acetyl shikonin	Others; P450; AChE	Metabolism; Neuroscience; Others
	Acetylshikonin 来源于紫草根，具有抗癌、抗炎作用。它是一种 AChE 抑制剂，具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂，对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。
TN2892	3,5,7-Trihydroxychromone	Others	Others
	3,5,7-Trihydroxychromone exhibits weak antiangiogenic activity.
T40942	(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone
	(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone, an antiangiogenic homoisoflavonoid, exhibits activity against human retinal microvascular endothelial cells.
TMA1743	Ergosterol peroxide	ERK; VEGFR; p38 MAPK; Wnt/beta-catenin; Akt; JAK; CDK; JNK; STAT; Antifection	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pro-apoptotic protein Puma and Bax to
TN2553	1-Methyl-2-undecyl-4(1H)-quinolone 1-Methyl-2-undecylquinolin-4(1H)-one	MAO	Metabolism; Neuroscience
	1-Methyl-2-undecyl-4(1H)-quinolone, and dihydroevocarpine should also be served as the chemical markers together with evodiamine for the quality control of Evodia rutaecarpa (Juss.) Benth. 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of type B MAO (MAO-B) activity with the IC(50) value of 15.3 microM using a substrate kynuramine, but does not inhibit type A MAO (MAO-A) activity.It can mitigate high phosphate-induced human aortic valve interstitial cells (HAVICs) calcification ...
T36749	Herboxidiene
	Herboxidiene is a polyketide originally isolated from S. chromofuscus that has diverse biological activities.[1],[2,][3],[4],[5] It inhibits growth of HeLa S3, SK-MEL-2, PC3, A549, and EBC-1 cells with GI50 values ranging from 7.4 to 62 nM.3 Herboxidiene is cytostatic against human umbilical vein endothelial cells (HUVECs; (IC50 = 26 nM)) and inhibits VEGF-induced invasion and tube formation of serum-starved HUVECs in a concentration-dependent manner, indicating antiangiogenic activity.[4] Herbo...

天然产物

Cat.No: TN1112

Target: Others

Cat.No: T3776

Synonym: 丹叶大黄素,Protigenin

Target: P450, Antibacterial, Antifungal

Mycophenolic acid

Cat.No: T1335

Synonym: 霉酚酸,Mycophenolate,RS-61443

Target: Apoptosis, Dehydrogenase, Endogenous Metabolite, Antibacterial, Antibiotic, UGT, Antifungal

Cat.No: T1011

Synonym: 伊曲康唑,R51211

Target: P450, Hedgehog/Smoothened, Antibiotic, Autophagy, Antifungal

Cat.No: T3S2027

Target: Others

Cat.No: T3878

Synonym: NSC382873,竹节香附素A,Anemodeanin A,Raddeanin R3

Target: Apoptosis, HDAC

(2S)-Isoxanthohumol

Cat.No: T4S0999

Synonym: Isoxanthohumol,(2S)-异黄腐酚,异黄腐醇

Target: Virus Protease, HSV

Cat.No: T3864

Target: BCL, Antibacterial

Cat.No: T7032

Target: Others, P450

Cat.No: T2S0886

Target: Apoptosis, Others

3',4',7-Trihydroxyisoflavone

Cat.No: TN1236

Target: MAPK, JNK

Cat.No: T5S2343

Synonym: 乙酰紫草素,Acetyl shikonin

Target: Others, P450, AChE

3,5,7-Trihydroxychromone

Cat.No: TN2892

Target: Others

(R)-(4′-Hydroxy)-5,7-dihydroxy-4-chromanone

Cat.No: T40942

Ergosterol peroxide

Cat.No: TMA1743

Target: ERK, VEGFR, p38 MAPK, Wnt/beta-catenin, Akt, JAK, CDK, JNK, STAT, Antifection

1-Methyl-2-undecyl-4(1H)-quinolone

Cat.No: TN2553

Synonym: 1-Methyl-2-undecylquinolin-4(1H)-one

Target: MAO

Cat.No: T36749

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