Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Terameprocol (EM-1421) 是 Nordihydroguaiaretic acid 的合成衍生物,是非选择性脂氧合酶抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 281 | 现货 | ||
10 mg | ¥ 460 | 现货 | ||
25 mg | ¥ 840 | 现货 | ||
50 mg | ¥ 1,347 | 现货 | ||
100 mg | ¥ 2,192 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 510 | 现货 |
产品描述 | Terameprocol (EM-1421) is a synthetic tetra-methylated derivative of nordihydroguaiaretic acid (NDGA) and transcriptional inhibitor with potential antiviral, antiangiogenic, and antineoplastic activities. Terameprocol showed the strongest anti-HIV activity. |
体外活性 | In Vero cells, Terameprocol inhibited Sp1 transcription factor binding at the HIV long terminal repeat promoter and at the α-ICP4 promoter with IC50 values of 11 and 43.5 μM, respectively. The IC50 of Terameprocol varied between 11.7 and 4 μM in 10 passages of HSV-1 and 4 passages of HSV-2 [2]. Terameprocol inhibited Sp1-dependent Cdc2 gene expression. In M4N-treated transformed C3 cells, Terameprocol induced growth arrest and apoptosis by suppressing Sp1-dependent Cdc2 and survivin gene expression giving rise to its antitumorigenic activity [3]. Terameprocol treatment suppressed expression of the Sp1-dependent survivin gene. In transiently and stably survivin-transfected C3 cells, Terameprocol reduced caspase-3 activation by 50% and 75%, respectively [3]. Terameprocol inhibited the growth of a number of tumor cell lines by inducing apoptosis in a non-schedule-dependent manner [4]. Terameprocol inhibited the synthesis of DNA by melanoma cells and causes cell cycle arrest in G0/G1 and G2/M phases of the cell cycle [4]. |
体内活性 | Terameprocol effectively inhibited the growth of human tumors in nude mice [5]. Terameprocol inhibited the growth of both murine and human melanomas and human colon cancer without apparent hepatic or renal toxicity [4]. In nude (nu/nu) mice bearing xenografts of human tumor types (Hep 3B, LNCaP, HT-29, MCF7, and K-562), treatment with Terameprocol (i.v. or i.p.) down-regulated Cdc2 and survivin genes expression [5]. |
别名 | tetramethyl Nordihydroguaiaretic Acid, EM-1421 |
分子量 | 358.47 |
分子式 | C22H30O4 |
CAS No. | 24150-24-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/ml (76.71 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.7896 mL | 13.9482 mL | 27.8963 mL | 69.7408 mL |
5 mM | 0.5579 mL | 2.7896 mL | 5.5793 mL | 13.9482 mL | |
10 mM | 0.279 mL | 1.3948 mL | 2.7896 mL | 6.9741 mL | |
20 mM | 0.1395 mL | 0.6974 mL | 1.3948 mL | 3.487 mL | |
50 mM | 0.0558 mL | 0.279 mL | 0.5579 mL | 1.3948 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Terameprocol 24150-24-1 Microbiology/Virology Proteases/Proteasome HIV Protease EM1421 inhibit LOX tetramethyl Nordihydroguaiaretic Acid Inhibitor Lipoxygenase EM 1421 EM-1421 inhibitor