128
26
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8308 |
NL-1
|
Mitochondrial Metabolism; Autophagy | Autophagy; Metabolism |
NL-1 是一种mitoNEET 抑制剂,具有抗白血病作用。它抑制 REH 和 REH/Ara-C 细胞生长,IC50分别为 47.35 µM 和 56.26 µM。 | |||
T9776 |
TRPM4 inhibitor 8
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
TRPM4 inhibitor 8 是瞬态受体电位 melastatin 4 (TRPM4) 的抑制剂,它有助于活力、迁移、细胞周期转变和粘附。 | |||
T9662 |
SRI 37892
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
SRI 37892是一种 Fzd7抑制剂,对 Wnt/β-catenin 信号传导和癌症细胞活性具有强大的活性。 | |||
T5627 |
Methoxychlor
|
Others | Others |
Methoxychlor 是一种有机氯农药,被认为是一种内分泌干扰物,会影响不同细胞模型中的 Ca²⁺ 稳态和细胞活力。 | |||
T7366 |
NGI-1
ML414 |
Virus Protease | Microbiology/Virology |
NGI-1 (ML414) 是一种可渗透细胞的寡糖转移酶 (OST) 抑制剂,直接靶向和阻断 OST 催化亚基 STT3A 和 STT3B 的功能,可有效降低病毒感染性而不影响细胞活力。 | |||
T16040 |
Mepazine
甲哌啶嗪,Pecazine |
Apoptosis; MALT | Apoptosis; Immunology/Inflammation |
Mepazine (Pecazine) 是一种有效的特异性 MALT1 抑制剂。 Mepazine 抑制 GSTMALT1 全长和 GSTMALT1 325-760,IC50 为 0.83 μM 和 0.42 μM。 Mepazine 增强细胞凋亡并影响细胞活力。 | |||
T12896L |
Shepherdin 79-87 acetate
Shepherdin 79-87 acetate (861224-28-4 free base) |
HSP; Survivin | Apoptosis; Cytoskeletal Signaling; Metabolism |
Shepherdin 79-87 acetate 是 Hsp90 和 survivin 之间复合物的拟肽拮抗剂,survivin 是肿瘤细胞活力的另一个关键调节剂。 | |||
T68051 |
Delequamine
RS 15385-197 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Delequamine (RS 15385-197) 是一种有效的选择性 α2-肾上腺素受体拮抗剂。 | |||
T6682 |
STF-118804
STF 118804,STF118804 |
Apoptosis; NAMPT | Apoptosis; Metabolism |
STF-118804是一种烟酰胺磷酸核糖基转移酶 Nampt 高选择性抑制剂,降低大多数 B-ALL 细胞系的活力,IC50 <10 nM。 | |||
T14017 |
2-NBDG
2-(N-7-硝基-2,1,3-苯并恶二唑-4-氨基)-2-脱氧-D-葡萄糖 |
Others | Others |
2-NBDG 是一种荧光指示剂 (λex=467 nm,λem=542 nm),是一种荧光 D-葡萄糖类似物,可用于监测活细胞中的葡萄糖吸收。 | |||
T77660 |
TINK-IN-1
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
TINK-IN-1 是一种具有选择性和高效性的 TNIK 抑制剂(IC50:8 nM)。TINK-IN-1 抑制结直肠癌细胞活力,可用于研究智力发育障碍。 | |||
T11940 |
Malic enzyme inhibitor ME1
ME1 |
Others | Others |
Malic enzyme inhibitor ME1 (ME1) 是苹果酸酶的特异性抑制剂 (IC50 = 0.15 μM)。 苹果酸酶抑制剂 ME1 降低细胞活力/代谢活性。 | |||
T72968 |
ZINC00640089
|
Akt | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
ZINC00640089 是一种选择性的脂质运载蛋白-2 (LCN2) 抑制剂。ZINC00640089 对细胞增殖、细胞活力有抑制作用,可减少 SUM149 细胞的 AKT 磷酸化水平。ZINC00640089 可用于研究炎症性乳腺癌 (IBC) 。 | |||
T83653 |
SACLAC
|
Apoptosis; Caspase | Apoptosis; Proteases/Proteasome |
SACLAC 是一种半胱天冬酶活化抑制剂,具有抗肿瘤活性,可降低AML细胞活力,抑制AML细胞增殖,增加AML细胞死亡,并诱导AML细胞凋亡,可用于研究急性髓系白血病和癌症。 | |||
T9955 |
EX-A5758
|
NOS | Immunology/Inflammation |
EX-A5758是一种新型推定的小分子 nNOS-NOS1 AP 抑制剂,可抑制炎症性伤害感受和化疗引起的神经性疼痛,并与紫杉醇协同降低肿瘤细胞活力 | |||
T28543 |
RK-9123016
RK9123016,RK 9123016 |
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
RK-9123016是一种SIRT2抑制剂。RK-9123016增加真核翻译起始因子5A(eIF5A)(SIRT2的生理底物)的乙酰化水平,降低人乳腺癌细胞的细胞活力,同时降低c-Myc 表达。 | |||
T18894 |
5(6)-CFDA
CFDA,5-(6)-Carboxyfluorescein diacetate,5(6)-羧基荧光素二乙酸酯 |
Others | Others |
5(6)-CFDA (5-(6)-Carboxyfluorescein diacetate) 是具有细胞渗透性的胺反应型绿色荧光探针(λex: 492 nm; λem: 517 nm),可用于细胞染色分析。 | |||
T1642 |
Lenalidomide
来那度胺,CC-5013 |
Apoptosis; TNF; Ligand for E3 Ligase; Molecular Glues | Apoptosis; PROTAC |
Lenalidomide (CC-5013) 是 Thalidomide 的衍生物,也是具有口服活性免疫调节剂,以分子胶的方式作用。它是泛素 E3 连接酶 cereblon (CRBN) 的配体,可通过 CRBN-CRL4 泛素连接酶对两种淋巴转录因子 IKZF1 和 IKZF3 进行选择性泛素化和降解。 | |||
T5580 |
1-Naphthaleneacetic acid potassium salt
α-萘醋酸钾,α-Naphthaleneacetic acid,Potassium alpha-naphthylacetate,Potassium 1-Naphthaleneacetate,1-NAA Potassium Salt |
Phospholipase | Metabolism |
1-Naphthaleneacetic acid potassium salt (1-NAA Potassium Salt) 是一种合成的植物生长素,能够促进植物生长,也是一种PLA2抑制剂,IC50=13.16 μM。 | |||
T1937 |
Spautin-1
Spautin 1 |
Apoptosis; DUB; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination |
Spautin-1是一种特异性自噬抑制剂,可抑制泛素特异性肽酶 USP10和 USP13,IC50s 约为0.6到0.7 μM。 | |||
T22429 |
SR18662
|
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
SR18662 是 ML264 类似物,可抑制 Krüppel 样因子 5 (KLF5),IC50 为 4.4 nM,降低多种结直肠癌细胞系的活力并诱导细胞凋亡。 | |||
T6911 |
NSC-87877 disodium
NSC87877 |
Apoptosis; Phosphatase | Apoptosis; Metabolism |
NSC-87877 disodium (NSC87877) 是一种有效的Shp2和Shp1蛋白质酪氨酸磷酸酶抑制剂,IC50值分别为0.318 μM 和0.355 μM。NSC-87877还抑制双特异性磷酸酶26。 | |||
T8421 |
TED-347
|
YAP | Stem Cells |
TED-347 是不可逆的、共价的 YAP-TEAD 蛋白质-蛋白质相互作用变构抑制剂,对 TEAD4•Yap1 蛋白质-蛋白质相互作用的 EC50为 5.9 μM。它与 TEAD4 中央口袋内的 Cys-367 特异性共价结合(Ki:10.3 μM)。它可以抑制 TEAD 的转录活性,并且具有抗肿瘤作用。 | |||
T37518 |
Diphenyl disulfide
Phenyl disulfide |
Apoptosis; BCL; Endogenous Metabolite | Apoptosis; Metabolism |
Diphenyl disulfide (Phenyl disulfide) 在乳腺癌细胞系中显示出抗癌活性。Diphenyl disulfide 通过Bax 蛋白水解活化和伴随的自噬来诱导并增强乳腺癌细胞的凋亡。Diphenyl disulfide 以剂量依赖性方式抑制细胞增殖和活力,并减少集落形成。Diphenyl disulfide 可用来治疗乳腺癌。 | |||
T13983 |
0990CL
|
cAMP; Others | GPCR/G Protein; Others |
0990CL 是一种有效的异三聚体Gαi subunit 特异性抑制剂,可与纯化的Go±在gdp 结合状态下相互作用,能够阻断α2AR 介导的cAMP 调控。 在细胞模型中低浓度0990CL 能够部分恢复cAMP 水平,高浓度的0990CL (10 μM)下,开始对细胞活力产生负面影响。 | |||
T28773 |
SI-2
SI2,EPH 116,EPH116,EPH-116 |
Others | Others |
SI-2是类固醇受体辅激活因子-3(SRC-3或 AIB1)的抑制剂(SMI)。SI-2可选择性降低细胞中 SRC-3的转录活性和蛋白浓度,并选择性诱导低纳摩尔范围(3-20 nM)内的乳腺癌症细胞死亡,但不影响正常细胞存活率。 | |||
T2331 |
Solithromycin
索利霉素,OP-1068,CEM-101 |
Antibacterial; Antibiotic | Microbiology/Virology |
Solithromycin (OP-1068) 是口服可生物利用的抗菌剂,抑制肺炎链球菌、葡萄球菌、金黄色葡萄球菌和流感嗜血杆菌的细胞活力、蛋白质合成和生长速率, IC50 值分别为 7.5 ng/mL、40 ng/mL 和 125 ng/mL。它可与核糖体的大 50S 亚基结合抑制蛋白质生物合成。 | |||
T36493 |
CMLD-2
|
Apoptosis; HuR | Apoptosis; Chromatin/Epigenetic |
CMLD-2是一种 HuR-ARE 相互作用的抑制剂(Ki:350 nM),能竞争性地结合 HuR 蛋白并破坏其与富含腺嘌呤元素(ARE)的 mRNA 目标的相互作用。CMLD-2诱导细胞凋亡并通过 MAD2下调表现出抗肿瘤作用。CMLD-2 (1-75 μM ; 24-72 h) 对甲状腺癌细胞的活力具有抑制作用.CMLD-2 (20-30 μM ; 24-48 h) 激活 Caspases 并诱导H1299和A549细胞凋亡.CMLD-2 (30 μM ; 24-48 h) 诱导H1299和A549细胞的G1细胞周期停止和线粒体扰动。 CMLD-2(30μM;24-48小时)减少H1299细胞中HuR 和HuR 调节的mRNAs 和蛋白质的表达.CMLD-2(35μM;72小时)降低SW1736、8505C、BCPAP 和K1细胞的定向迁移能力。CMLD-2诱导SW1736、8505C、BCPAP 和K1细胞中的MAD2 mRNA 水平强烈下降。 | |||
T34695 |
Spiclomazine HCl
APY-606,Diceplon,Disepron,APY606,Spiclomazine Hydrochloride |
||
Spiclomazine HCl induced apoptosis in pancreatic cancer cells, which was generally related to cell viability, migration, and invasion. | |||
T24423 |
LY5
LY 5,LY-5 |
||
LY5 is an inhibitor of STAT3 that acts by inhibiting cell viability, cell migration, and angiogenesis in medulloblastoma cells. | |||
T36141 |
Boscalid
|
Mitochondrial Metabolism | Metabolism |
Boscalid 是一种广谱羧酰胺类杀菌剂,通过与线粒体复合物 II/琥珀酸脱氢酶的泛醌位点结合来抑制真菌呼吸。 | |||
T7650L |
Resazurin
Resazoin,Diazoresorcinol,Azoresorcin,Resazurine |
||
Resazurin is used as an oxidation-reduction indicator in cell viability. | |||
T71413 |
U 26384
|
||
U 26384 is a phospholipase A2 inhibitor reduces the severity of cell injury, but does not maintain cell viability in cultured human astroglial cell line UC-11MG during ATP depletion. | |||
T19771 |
SXT1596
NSC-65667,SXT-1596,NSC 65667,SXT 1596,NSC65667 |
||
SXT1596 is a novel SS18-SSX/TLE1 interaction inhibitor. SXT1596 reduces cell viability and reactivates EGR1 expression in synovial sarcoma. | |||
T40143 |
PROTAC CBP/P300 Degrader-1
PROTAC CBP/P300 Degrader-1 |
||
PROTAC CBP/P300 Degrader-1 is an effective compound that degrades CBP/P300 in a potent manner. It significantly reduces cell viability in various cancer cell lines. | |||
T31696 |
EthD-1
EthD1,Ethidium Homodimer-1 |
||
EthD-1 is a cell-impermeant viability indicator. It acts as a high-affinity nucleic acid stain. | |||
T68773 |
NSC-311068
|
||
NSC-311068 is a novel selective inhibitor of TET1 transcription and 5-hydroxymethylcytosine (5hmC) modification, effectively inhibiting cell viability in AML with high expression of TET1. | |||
T71620 |
iBAP-II
|
||
iBAP-II represses neuroendocrine lineage-specific ASCL1/MYCL/E2F signaling in SCLC cell lines, and dramatically inhibits SCLC cell viability and tumor growth in vivo. | |||
T18932 |
Calcein tetraethyl ester
钙黄绿素四乙酯,Fluorexon tetraethyl ester |
Others | Others |
Calcein tetraethyl ester, a fluorescent dye, is utilized in biological studies for its ability to penetrate cellular membranes into living cells. This property renders it valuable for assessing cell viability and short-term cell labeling. | |||
T33219 |
MB725
MB 725,MB-725 |
||
MB725 is a strong and selective inducer of viability reduction in several cancer cell lines containing the oncogenic p53-Y220C mutation. | |||
T18931 |
Calcein-AM
Calcein acetoxymethyl ester,钙黄绿素-AM |
Others | Others |
Calcein-AM is a cell-permeable fluorescent dye used for the determination of cell viability. | |||
T37602 | GSK 143 | ||
Spleen tyrosine kinase (Syk) inhibitor (pIC50 = 7.5). Also inhibits phosphorylated Erk (pIC50 = 7.1). Decreases cell number and viability in chronic lymphocytic leukemia (CCL) cell lines. Liddle et al (2011) Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor. Bioorg.Med.Chem.Lett. 21 6188 PMID:21903390 |Varghese et al (2018) Highly selective SYK inhibitor, GSK143, abrogates survival signals in chronic lymphocytic leukaemia. Br.J.Haematol 182 9... | |||
T36326 |
Calcein Orange™ Diacetate
|
||
Calcein Orange Diacetate is a fluorogenic dye that is used to assess cell viability. It is hydrolyzed to the fluorescent probe Calcein Orange . Calcein Orange is retained by living cells and displays excitation/emission maxima of 525/550 nm, respectively. Calcein Orange Diacetate is an orange-emitting variant of the green fluorophore Calcein AM , which has been used to evaluate cell viability and cytotoxicity. | |||
T11972 | Mcl-1 inhibitor 3 | BCL | Apoptosis |
Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.Mcl-1 inhibitor 3 is a highly potent and orally activate macrocyclic Mcl-1 inhibitor (Ki= 0.061 nM; IC50=19 nM in an OPM-2 cell viability assay). | |||
T35611 |
CytoCalcein™ Violet 450
|
||
CytoCalcein Violet 450 is a fluorogenic dye used to assess cell viability. It is a cell-permeable dye that, upon entering cells, is cleaved by intracellular esterases. CytoCalcein Violet 450 is retained by living cells and displays excitation/emission maxima of 405/450 nm, respectively. | |||
T16131 |
MPT0E028
|
Others | Others |
MPT0E028 is an orally active and selective inhibitor of HDAC (IC50s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2, and HDAC6, respectively). MPT0E028 has good anticancer activity. MPT0E028 decreases the viability of B-cell lymphomas by inducing apoptosis | |||
T36327 |
Calcein Red™ AM
|
||
Calcein Red AM is a fluorogenic dye that is used to assess cell viability. As the acetoxymethyl ester, Calcein Red AM is non-fluorescent but cell-permeant and is hydrolyzed to the fluorescent probe Calcein Red by intracellular esterases. Calcein Red is retained by living cells and displays excitation/emission maxima of 560/574 nm, respectively. Calcein Red AM is a red-emitting variant of the green fluorophore calcein AM , which has been used to evaluate cell viability and cytotoxicity. | |||
T70291 |
PCC0208018
|
||
PCC0208018 is a novel activator of effector T cells, enhancing T cell proliferation and activation to release interferon gamma (IFN-γ) and interleukin-2 (IL-2) without blocking the programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) binding and not directly affecting tumor cell viability in vitro. | |||
T70103 | KSK213 | ||
KSK213 is a potent inhibitor of Chlamydia trachomatis Infectivity (EC50 = 60 nM). KSK213 potently inhibited multiple serovars of C. trachomatis while not affecting the growth of key species from the commensal flora or host cell viability at 25 μM. | |||
T71639 |
AUH-6-96
|
||
AUH-6-96 is an inhibitor of JAK/STAT signaling, inhibiting both constitutive and interleukin-6-induced STAT3 phosphorylation, selectively affecting cell viability only of cancer cells harboring aberrant JAK/STAT signaling. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7982 |
3,6-Dihydroxyflavone
|
Others | Others |
3,6-Dihydroxyflavone 是一种抗癌剂。它能够提高细胞内氧化应激和脂质过氧化。它是能够根据剂量和时间依赖性地降低细胞活力,并活化半胱天冬酶级联、切割聚 (ADP-核糖) 聚合酶 (PARP) 诱导细胞凋亡。 | |||
T2S1396 |
3-O-Acetyloleanolic acid
齐墩果酸3-乙酸酯,齐墩果酸 3-乙酸酯 |
Apoptosis | Apoptosis |
3-O-Acetyloleanolic acid 是从 Vigna sinensisK. 种子中提取得到的一种齐墩果醇酸,可诱导癌细胞凋亡并拥有抗血管生成作用。 | |||
TN1425 |
Bacoside A3
苦艾素A3,白花猪母菜甙 A3 |
ATPase; ROS; P-gp | Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience |
Bacoside A3 是一种天然的三萜皂苷,是Bacopa monnieri 的主要活性成分之一,显示出神经保护活性。 | |||
T6S1780 |
Protosappanin B
原苏木素B,Q-100961,FT-0689654 |
Apoptosis | Apoptosis |
Protosappanin B (Q-100961) 是从苏木中提取的一种多酚类天然产物,具有抗肿瘤作用。它通过激活 MDM2 依赖性泛素化过程诱导 p53 蛋白降解。它显著提高细胞活力,抑制细胞凋亡并上调生长相关蛋白 43 的表达。 | |||
T5S0636 |
Citric acid
柠檬酸,Citro,Citretten |
Apoptosis; Others; Endogenous Metabolite; Antibacterial; Antibiotic | Apoptosis; Metabolism; Microbiology/Virology; Others |
Citric acid (Citro) 是柑橘类水果中发现的弱有机三羧酸。柠檬酸是食品添加剂和天然防腐剂。 | |||
TN1405 |
Arnicolide D
山金车内酯 D,山金车内酯D |
Akt; Caspase; PI3K; STAT; mTOR | Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells |
Arnicolide D 是从石胡荽中分离出的一种倍半萜内酯,以浓度和时间依赖性方式抑制鼻咽癌细胞活力。它调节细胞周期,激活 caspase 信号通路并抑制 PI3K/AKT/mTOR 和 STAT3 信号通路。 | |||
T3S1873 |
Talatisamine
塔拉乌头胺,塔拉萨敏 |
Potassium Channel | Membrane transporter/Ion channel |
Talatisamine 是一种乌头生物碱,对K+通道有特异性阻滞作用。它能减弱 beta- 淀粉样低聚物对培养的皮层神经元的毒性。 | |||
T6S1653 |
Albiflorin
Alibiflorin,芍药内酯苷 |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
Albiflorin (Alibiflorin) 是一种牡丹根中的主要成分,是一种单萜糖苷。它具有神经保护、抗炎、抗氧化和缓解疼痛作用。 | |||
T2897 |
(Rac)-Shikonin
(±)-Shikonin,Alkanet extract,Anchusin,紫草素,Anchusa acid |
Others | Others |
(Rac)-Shikonin (Anchusin) 具有抗肿瘤作用。它能够诱导坏死死亡来绕过癌症耐药性。 | |||
T4S1615 |
Sanggenon C
桑根酮C,桑根酮 C,Sanggenone C |
NF-κB | NF-κB |
Sanggenon C (Sanggenone C) 是一种从桑属的根皮中分离得到的黄烷酮 Diels-Alder 加合物化合物。它可抑制NF-κB 活性,抑制 RAW264.7 细胞中诱导型一氧化氮合酶的表达,以及肿瘤坏死因子-α 刺激的细胞粘附和血管细胞粘附分子-1 的表达。 它具有抗氧化和抗炎作用,也有抑制胰脂肪酶作用。 | |||
T6S2391 |
L-Chicoric Acid
(-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,L-菊苣酸,dicaffeoyltartaric acid,菊苣酸 |
Others; HIV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
L-Chicoric Acid (trans-Caffeoyltartaric acid) 是一种二咖啡酰酒石酸,是一种选择性可逆的 HIV-1 整合酶抑制剂,IC50约为 100 nM。它还可抑制 HIV-1 复制。 | |||
T40834 |
5-Hydroxymethyl-2'-deoxycytidine
5hmdC,2'-脱氧-5-(羟甲基)胞啶 |
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
5-Hydroxymethyl-2'-deoxycytidine 是 DNA 中 5-methyl-2'-deoxycytidine (5-mdC) 的氧化衍生物,引起DNA损伤反应,染色体畸变,复制叉损伤和细胞活力丧失。5-Hydroxymethyl-2’-deoxycytidine 复制叉不稳定性与染色质上聚(ADP-核糖)聚合酶1(PARP1)的存在有关。 | |||
T4958 |
(-)-Alkannin
Alkannin,左旋紫草素,紫草素,Shikonin |
Apoptosis; PI3K | Apoptosis; PI3K/Akt/mTOR signaling |
(-)-Alkannin (Shikonin) 是从紫朱草中发现的一种天然产物,具有抗癌活性,可抑制细胞周期,诱导细胞凋亡,用作食品着色剂,在 Rho 激酶途径中可改善肝脏炎症。 | |||
T2860 |
Vanillyl Alcohol
4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,香兰醇,Vanillin alcohol,Vanillic alcohol |
Apoptosis; Others | Apoptosis; Others |
Vanillyl Alcohol (3-Methoxy-4-hydroxybenzyl alcohol) 是一种酚类醇,具有抗血管生成、抗惊厥、抗炎、抗氧化、神经保护和抗伤害活性。它由香兰素衍生而来,在食品和饮料中用作调味剂。 | |||
T5S0053 |
Coptisine
黄连碱,Coptisin |
Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
Coptisine (Coptisin) 是一种从黄连中分离到的生物碱,是非竞争性的IDO 抑制剂,Ki=为 5.8 μM,IC50=6.3 μM。 | |||
T3826 |
Polygalasaponin F
异牡荆苷,瓜子金皂苷己 |
NF-κB; TLR; Akt; PI3K | Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling |
Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷,可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌,能降低炎性细胞因子肿瘤坏死因子 α 的释放。 | |||
T38495 |
Gypenoside LXXV
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Gypenoside LXXV, derived from Gynostemma pentaphyllum, is a deglycosylated form of ginsenoside Rb1. This compound effectively decreases cancer cell viability and exhibits potent anti-cancer properties. | |||
TN3737 |
Cycloartane-3,24,25-triol
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ATPase | Membrane transporter/Ion channel |
Cycloartane-3,24,25-triol has potential for development as an anti-cancer agent against prostate cancer. It reduces the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively. | |||
TN3742 |
Cycloeucalenol
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Others | Others |
Cycloeucalenol produces mild cardiotonic effects. Cycloeucalenol and its regio-isomer were present in a ratio of 1.04:1, a dose-dependent decrease in cell viability was observed. | |||
TN4699 | Ohchinin | Others | Others |
Ohchinin exhibits potent inhibitory activities with 26 - 66% reduction of melanin content at 100 μm concentration with almost no or low toxicity to the B16 melanoma cells (70 - 99% cell viability at 100 μm). | |||
T13922 |
Thevetiaflavone
2-Genistein-5-methyl ether,Apigenin-5-methyl ether |
BCL; Caspase | Apoptosis; Proteases/Proteasome |
Thevetiaflavone (2-Genistein-5-methyl ether) 是一种来自 Wikstroemia indica 的天然类黄酮,可抑制乳酸脱氢酶从细胞质中泄漏并提高细胞活力。 | |||
T79982 |
2'-epi-2'-O-Acetylthevetin B
GHSC-74 |
Apoptosis | Apoptosis |
2'-epi-2'-O-Acetylthevetin B (GHSC-74) 为源自Cerbera manghas L种子的强心苷,其抑制HepG2细胞增殖并诱导细胞凋亡(apoptosis)及线粒体膜电位降低。 | |||
TN1440 |
Beta-Hydroxyisovalerylshikonin
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EGFR; Tyrosine Kinases; Prostaglandin Receptor; Src; AMPK; Fatty Acid Synthase | Angiogenesis; Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; Metabolism; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
Beta-hydroxyisovalerylshikonin 是分离自Lithospermium radix 的天然产物,具有抑制PTK 的作用, 对 EGFR 和 v-Src 受体作用的IC50分别为 0.7 μM 和 1 μM。它对多种肿瘤细胞系均有抑制作用,可以高效诱导 NCI-H522 和 DMS114 细胞的死亡。 | |||
T35770 |
Cylindrospermopsin
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Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 µM, respectively), leading to cell death. [1] It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a Ki value of 10 &... | |||
TN4592 |
Murrangatin
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IL Receptor; TNF; COX; Prostaglandin Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line, | |||
TN3323 |
Monomethyl lithospermate
Lithospermic acid monomethyl ester |
Akt; PI3K | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
Monomethyl lithospermate (Lithospermic acid monomethyl ester) 具有潜在的抗病毒活性,通过激活PI5K/Akt信号传导,减轻体内大脑中动脉闭塞小鼠缺血性中风损伤,并在体外保护氧葡萄糖剥夺/复氧诱导的SHSY-3Y细胞。Monomethyl lithospermate 能提高 SHSY-5Y 细胞的生存能力,抑制线粒体膜电位 (MMOP) 崩溃,抑制细胞凋亡。Monomethyl lithospermate 还降低中动脉闭塞 (MCAO) 大鼠脑组织中的氧化应激水平,改善缺血性中风 (IS) 大鼠神经损伤。 |