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Search Results for " antidiabetic "

67

抑制剂 & 化合物

57

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Cat. No.	Product Name	Target	Signaling Pathways
T79644	Antidiabetic agent 2	Glucosidase	Metabolism
	Antidiabetic agent 2 (Compound 56) 作为一种葡萄糖摄取促进剂，能有效地抑制DPP-4, PTP-1B, α-淀粉酶和α-葡萄糖苷酶，其IC50s分别达到0.036、0.042、0.241、0.185 μM，表现出显著的降血糖作用。
T8224	VU0119498	AChR	Neuroscience
	VU0119498 是泛 GqmAChR M1、M3和M5的正变构调节剂，具有抗糖尿病活性，EC50值分别为 6.04、6.38 和 4.08 µM。
T15385	Glibornuride	Potassium Channel	Membrane transporter/Ion channel
	Glibornuride 是对 ATP 敏感的 K+通道 (KATP 通道) 阻滞剂，pKi 为 5.75。Glibornuride 显示抗糖尿病活性。
T4304	Azoramide	Apoptosis; PERK	Apoptosis
	Azoramide 是一种小分子调节剂，具有未折叠蛋白反应的抗糖尿病活性。
T31976	Glymidine sodium	Others	Others
	Glymidine sodium 是口服有活性的抗糖尿病药物，也是肝脂肪分解的抑制剂。它通过抑制葡萄糖的形成，也对由于内源性脂质动员抑制而导致的丙酮酸氧化升高具有抑制作用。
T9590	T-1095	SGLT; transporter	GPCR/G Protein; Metabolism
	T-1095 是一种口服有活性的Na+-葡萄糖协同转运蛋白选择性抑制剂，能够抑制 SGLT1 (IC50:22.8 µm) 及 SGLT2 (IC50:2.3 µm) 。它可用于研究糖尿病。
T15656	KGA-2727	SGLT	GPCR/G Protein
	KGA-2727是选择性，高亲和力和口服有效的 SGLT1抑制剂，对人和大鼠 SGLT1的 Ki 分别为 97.4 nM 和 43.5 nM，对 SGLT1的选择性比人SGLT2 高 140 倍，大鼠SGLT2高390 倍。KGA-2727具有抗糖尿病活性。
T6759	AP-III-a4 ENOblock	Glucokinase	Metabolism
	AP-III-a4 (ENOblock) 是第一个非底物类似物，可直接与烯醇酶结合，IC50=0.576 uM，可阻碍体内癌细胞转移。
T22967	MEDICA16 MEDICA 16	GPR; Others; ATP Citrate Lyase	Endocrinology/Hormones; GPCR/G Protein; Metabolism; Others
	MEDICA16 是 GPR40 的特异性激动剂以及 GPR120 的部分激动剂。 MEDICA16 是一种 ATP-柠檬酸裂解酶抑制剂，可显着降低腓肠肌中的细胞内 TG 含量，同时增加胰岛素敏感性。
T38843	Enavogliflozin DWP-16001	SGLT	GPCR/G Protein
	Enavogliflozin (DWP-16001) 是一种口服有效的，选择性的钠-葡萄糖协同转运体 -2 抑制剂，具有抗糖尿病的功效。
T16074	Mifobate SR-202,米福贝特	PPAR	DNA Damage/DNA Repair; Metabolism
	Mifobate (SR-202) 是一种有效且特异性的 PPARγ拮抗剂，可选择性抑制噻唑烷二酮 (TZD) 诱导的 PPARγ 转录活性，IC50为140 μM，具有抗肥胖和抗糖尿病作用。
T20029	Buformin hydrochloride NSC528218,NSC-528218,盐酸丁双胍,NSC 528218	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Buformin hydrochloride (NSC-528218) 是一种有效的 AMPK 激活剂，是一种双胍类的口服抗糖尿病药物。Buformin 延缓胃肠道对葡萄糖的吸收，增加胰岛素敏感性和葡萄糖对细胞的吸收，并抑制肝脏对葡萄糖的合成。Buformin 也具有抗癌活性，可用于各种癌症研究。
T2607	MSDC 0160 CAY10415,Mitoglitazone,MSDC0160,MSDC-0160	Others; IGF-1R; Mitochondrial Metabolism	Metabolism; Others; Tyrosine Kinase/Adaptors
	MSDC 0160 (CAY10415) 是一种线粒体丙酮酸载体(MPC) 的调节剂，也是调节噻唑烷二酮的线粒体靶标 (mTOT) 的胰岛素增敏剂。它是一种噻唑烷二酮 (TZD)，具有抗糖尿病和神经保护活性作用。它具有用于阿尔茨海默氏病的潜力。
T12412L	PDK4-IN-1 hydrochloride	Apoptosis; PDK	Apoptosis; PI3K/Akt/mTOR signaling
	PDK4-IN-1 hydrochloride 是一种蒽醌衍生物，对丙酮酸脱氢酶激酶 4有抑制作用，IC50为 84 nM，具有口服活性。它抑制细胞转化和细胞增殖并诱导细胞凋亡。它具有抗过敏，抗糖尿病和抗癌作用。
T16083	Mizagliflozin GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base	SGLT	GPCR/G Protein
	Mizagliflozin (GSK-1614235 free base) 是口服有效的、选择性的 SGLT1抑制剂，对人 SGLT1 的 Ki 值为 27 nM。Mizagliflozin 对 SGLT1 的选择性是 SGLT2的303 倍。它是抗糖尿病药物，可以改善餐后血糖波动。它在改善慢性便秘方面具有潜在的作用。
T29019	TS-021 TS021,TS 021,TS-021 Free	DPP-4	Proteases/Proteasome
	TS-021 是一种具有选择性的二肽基肽酶 4 (DPP-4) 抑制剂，具有抗糖尿病活性，可用于研究2 型糖尿病。
T8345	Carbutamide	Others	Others
	Carbutamide 是一代磺酰脲，口服具有活性，具有降血糖作用。
T11942	MAP4K4-IN-3 Compound 17	MAPK	MAPK
	MAP4K4-IN-3 (Compound 17) 是 MAP4K4选择性抑制剂，在激酶实验中 IC50为 14.9 nM，在细胞实验中 IC50为 470 nM。具有抗糖尿病作用。
T22708	Darglitazone CP-86325	PPAR	DNA Damage/DNA Repair; Metabolism
	Darglitazone (CP-86325) 是一种噻唑烷二酮，是口服有效的PPAR-γ选择性激动剂。Darglitazone 可以有效控制血糖和脂质代谢，在 II 型糖尿病中有研究价值。
T10561	BM-131246	Others	Others
	BM-131246 是一种可口服的且具有抗糖尿病活性的噻唑烷二酮衍生物，可用于研究糖尿病。
T8750	LX-4211 intermediate	Others	Others
	LX-4211 intermediate 是LX-4211的合成中间体。LX-4211是有效的SGLT1/2抑制剂，用作抗糖尿病剂。
T11467	GSK-3β inhibitor 1	GSK-3	PI3K/Akt/mTOR signaling; Stem Cells
	GSK-3β inhibitor 1 是一种糖原合成酶激酶 3β (GSK-3β)的抑制剂，其 IC50=4.9 nM，可用于糖尿病的研究。
T9999	Sirtuin modulator 2 N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide	Others; Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) 具有抗糖尿病、抗炎和抗肿瘤活性。
T12400	Peliglitazar racemate (Rac)-Peliglitazar,(Rac)-BMS 426707-01,BMS 426707-01 racemate	PPAR	DNA Damage/DNA Repair; Metabolism
	Peliglitazar racemate(BMS 426707-01 racemate) 是 Peliglitazar 的外消旋体。Peliglitazar racemate 可作为潜在的抗糖尿病和抗肥胖剂。
TP2320	Pramlintide acetate(151126-32-8 free base)	Others	Others
	Pramlintide acetate是人源淀粉样肽的多肽类似物。作为一种抗糖尿病药物，它在结直肠癌中展现出抗肿瘤活性。
T1622	Rosiglitazone maleate BRL 49653C,BRL 49653,马来酸罗格列酮	Ferroptosis; TRP/TRPV Channel; PPAR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	Rosiglitazone maleate (BRL 49653) 是一种选择性PPARγ激活剂，具有抗糖尿病特性和潜在抗肿瘤活性。它也是TRP 通道调节剂，可抑制 TRPM2、TRPM3 的活性，激活 TRPC5。
T9178	(E/Z)-GSK-3β inhibitor 1 GSK-3β inhibitor 1	GSK-3	PI3K/Akt/mTOR signaling; Stem Cells
	(E/Z)-GSK-3β inhibitor 1 是 (E)-GSK-3β inhibitor 1 和 (Z)-GSK-3β inhibitor 1 的消旋体。它是一种糖原合成酶激酶 3β (GSK-3β)的抑制剂，可其对 GSK-3β 的 IC50=4.9 nM，用于糖尿病的研究。
T23389	SR1664 SR 1664	PPAR	DNA Damage/DNA Repair; Metabolism
	SR1664 是一种PPARγ拮抗剂，与结合PPARγ，可有效抑制 Cdk5 介导的PPARγ磷酸化，IC50为80 nM，Ki 为 28.67 nM。
T8615	ISOTHIAZOLINE 1,1-DIOXIDE 异噻唑烷 1,1-二氧化物,isothiazolidine 1,1-dioxide	Others	Others
	ISOTHIAZOLINE 1,1-DIOXIDE (isothiazolidine 1,1-dioxide) 是一种反应物，用于合成口服生物可利用的 hebatits B caspid 抑制剂，并用于制备隐花色素抑制剂作为抗糖尿病药物。
T67898	α-Glucosidase-IN-22	Glucosidase	Metabolism
	α-Glucosidase-IN-22是一种α-葡萄糖苷酶选择性抑制剂（IC50=0.64 μM）。α-Glucosidase-IN-22有抗糖尿病的活性，在2型糖尿病(T2DM)研究中具有潜力。
T73578	JY-2	FOXO1	Apoptosis
	JY-2 是一种具有口服活性和选择性的叉头转录因子 O1 (FoxO1) 抑制剂，具有抗糖尿病活性，对 FoxO1 转录有抑制作用。JY-2 可用于研究银屑病和糖尿病。
T0214L	Pioglitazone hydrochloride U-72107E,AD 4833,U 72107A,Pioglitazone HCl,匹格列酮盐酸盐	Ferroptosis; PPAR	Apoptosis; DNA Damage/DNA Repair; Metabolism
	Pioglitazone hydrochloride (AD 4833) 是一种选择性PPARγ激动剂，高亲和力结合到 PPARγ 配体结合域。作用于人和鼠 PPARγ，EC50分别为 0.93 和 0.99 μM。它是一种口服活性噻唑烷二酮的盐酸盐，具有抗糖尿病特性和潜在的抗肿瘤活性。
T1634	Glibenclamide 格列本脲,Glyburide	Potassium Channel; Mitochondrial Metabolism; CFTR; P-gp; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Glibenclamide (Glyburide) 是一种具有口服活性的 ATP 敏感的 K+通道抑制剂，可研究糖尿病和肥胖。它抑制 P-糖蛋白，可直接结合并阻断 KATP 的 SUR1亚基并抑制囊性纤维化跨膜传导调节蛋白。它通过诱导膜离子通透性干扰线粒体生物能，可诱导自噬。
T27402	Garvagliptin
	Garvagliptin has antidiabetic activity.
T31627	Englitazone sodium CP-72,467-2,D03996,CP-72467-2,Englitazone sodium (USAN)
	Englitazone sodium is an antidiabetic agent and a novel NSCA and KATP channel blocker.
T68445	Clomoxir
	Clomoxir is a carnitine palmitoyltransferase I inhibitor that was under development as an antiarrhythmic and antidiabetic.
T38998	Pramlintide
	Pramlintide, a polypeptide analog of human amylin, is an antidiabetic agent with antineoplastic properties in colorectal cancer.
T61519	α-Glucosidase-IN-18
	α-Glucosidase-IN-18 (7B) is an orally active inhibitor of α-glucosidase, displaying an IC 50 value of 3.96 μM. This compound exhibits antidiabetic properties [1].
T61503	α-Glucosidase-IN-15
	α-Glucosidase-IN-15 (Compound 14B) exhibits potent inhibitory activity against α-glucosidase, with an IC50 value of 3.34 μM. It possesses antidiabetic properties [1].
T75709	Pramlintide TFA
	Pramlintide TFA，一种人类淀粉样肽类似物，主要作为抗糖尿病药物使用，并可用于肠癌研究。
T11248	Evogliptin tartrate DA-1229 tartrate	DPP-4	Proteases/Proteasome
	Evogliptin tartrate has potential for anti-atherosclerosis therapy that targets arterial inflammation. Evogliptin tartrate is a potent, orally bioavailable and selective dipeptidyl peptidase-4 (DPP-4) inhibitor, with antidiabetic activity.
T22860	Imeglimin	Others	Others
	Imeglimin is the first in a new tetrahydrotriazine-containing class of oral antidiabetic agents. It has been shown to act on the liver, muscle, and pancreatic β-cells to uniquely target the key defects of type 2 diabetes.
T80711	α-Glucosidase-IN-39	Glucosidase	Metabolism
	α-Glucosidase-IN-39 是一种针对α-glucosidase enzyme 的有效抑制剂，具有 869.06 ppm 的 IC50 值，适用于抗糖尿病研究。
T61249	α-Glucosidase-IN-2
	α-Glucosidase-IN-2 (compound 5d) 是一种有效的α-Glucosidase 抑制剂，IC50of 9.48 μM。α-Glucosidase-IN-2 是一种抗糖尿病药物。
T79911	O-Benzoylhydroxylamine
	O-Benzoyloxyamine 为一种DPP-IV 抑制剂，具备抗糖尿病功能。
T23837	Buformin 丁双胍,W37,W 37,H 224,W-37
	Buformin (1-butylbiguanide) is an oral antidiabetic drug of the biguanide class. It also inhibits the synthesis of glucose by the liver. Buformin delays absorption of glucose from the gastrointestinal tract increases insulin sensitivity and glucose uptake
T14040	4-Hydroxytolbutamide Hydroxytolbutamide	Potassium Channel	Membrane transporter/Ion channel
	4-Hydroxytolbutamide(Hydroxytolbutamide), a metabolite of Tolbutamide, which is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2].
T62891	α-Glucosidase-IN-19
	α-Glucosidase-IN-19 (Compound 6B) 是一种口服具有活力的 α-glucosidase 抑制剂 (IC50: 3.63 μM)，具有抗糖尿病作用。
T70280	KB-R7785
	KB-R7785 is a novel ADAM12 and MMP inhibitor, ameliorating cardiac function in a transverse aortic constriction (TAC) model by inhibiting the proteolytic activation of HB-EGF signaling, exerting its antidiabetic effect by ameliorating insulin sensitivity through the inhibition of TNF-alpha production.
T61166	α-Glucosidase-IN-16
	α-Glucosidase-IN-16 is a highly effective and orally bioavailable inhibitor of α-glucosidase, displaying a remarkable IC50 value of 3.28 μM. This compound demonstrates the ability to significantly decrease blood glucose levels in diabetic rats induced by Streptozotocin. Notably, α-Glucosidase-IN-16 also exhibits noteworthy antidiabetic activity [1].

化合物

Antidiabetic agent 2

Cat.No: T79644

Target: Glucosidase

Cat.No: T8224

Target: AChR

Cat.No: T15385

Target: Potassium Channel

Cat.No: T4304

Target: Apoptosis, PERK

Glymidine sodium

Cat.No: T31976

Target: Others

Cat.No: T9590

Target: SGLT, transporter

Cat.No: T15656

Target: SGLT

Cat.No: T6759

Synonym: ENOblock

Target: Glucokinase

Cat.No: T22967

Synonym: MEDICA 16

Target: GPR, Others, ATP Citrate Lyase

Cat.No: T38843

Synonym: DWP-16001

Target: SGLT

Cat.No: T16074

Synonym: SR-202,米福贝特

Target: PPAR

Buformin hydrochloride

Cat.No: T20029

Synonym: NSC528218,NSC-528218,盐酸丁双胍,NSC 528218

Target: AMPK

Cat.No: T2607

Synonym: CAY10415,Mitoglitazone,MSDC0160,MSDC-0160

Target: Others, IGF-1R, Mitochondrial Metabolism

PDK4-IN-1 hydrochloride

Cat.No: T12412L

Target: Apoptosis, PDK

Cat.No: T16083

Synonym: GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base

Target: SGLT

Cat.No: T29019

Synonym: TS021,TS 021,TS-021 Free

Target: DPP-4

Cat.No: T8345

Target: Others

Cat.No: T11942

Synonym: Compound 17

Target: MAPK

Cat.No: T22708

Synonym: CP-86325

Target: PPAR

Cat.No: T10561

Target: Others

LX-4211 intermediate

Cat.No: T8750

Target: Others

GSK-3β inhibitor 1

Cat.No: T11467

Target: GSK-3

Sirtuin modulator 2

Cat.No: T9999

Synonym: N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide

Target: Others, Sirtuin

Peliglitazar racemate

Cat.No: T12400

Synonym: (Rac)-Peliglitazar,(Rac)-BMS 426707-01,BMS 426707-01 racemate

Target: PPAR

Pramlintide acetate(151126-32-8 free base)

Cat.No: TP2320

Target: Others

Rosiglitazone maleate

Cat.No: T1622

Synonym: BRL 49653C,BRL 49653,马来酸罗格列酮

Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy

(E/Z)-GSK-3β inhibitor 1

Cat.No: T9178

Synonym: GSK-3β inhibitor 1

Target: GSK-3

Cat.No: T23389

Synonym: SR 1664

Target: PPAR

ISOTHIAZOLINE 1,1-DIOXIDE

Cat.No: T8615

Synonym: 异噻唑烷 1,1-二氧化物,isothiazolidine 1,1-dioxide

Target: Others

α-Glucosidase-IN-22

Cat.No: T67898

Target: Glucosidase

Cat.No: T73578

Target: FOXO1

Pioglitazone hydrochloride

Cat.No: T0214L

Synonym: U-72107E,AD 4833,U 72107A,Pioglitazone HCl,匹格列酮盐酸盐

Target: Ferroptosis, PPAR

Cat.No: T1634

Synonym: 格列本脲,Glyburide

Target: Potassium Channel, Mitochondrial Metabolism, CFTR, P-gp, Autophagy

Cat.No: T27402

Englitazone sodium

Cat.No: T31627

Synonym: CP-72,467-2,D03996,CP-72467-2,Englitazone sodium (USAN)

Cat.No: T68445

Cat.No: T38998

α-Glucosidase-IN-18

Cat.No: T61519

α-Glucosidase-IN-15

Cat.No: T61503

Pramlintide TFA

Cat.No: T75709

Evogliptin tartrate

Cat.No: T11248

Synonym: DA-1229 tartrate

Target: DPP-4

Cat.No: T22860

Target: Others

α-Glucosidase-IN-39

Cat.No: T80711

Target: Glucosidase

α-Glucosidase-IN-2

Cat.No: T61249

O-Benzoylhydroxylamine

Cat.No: T79911

Cat.No: T23837

Synonym: 丁双胍,W37,W 37,H 224,W-37

4-Hydroxytolbutamide

Cat.No: T14040

Synonym: Hydroxytolbutamide

Target: Potassium Channel

α-Glucosidase-IN-19

Cat.No: T62891

Cat.No: T70280

α-Glucosidase-IN-16

Cat.No: T61166

Cat. No.	Product Name	Target	Signaling Pathways
TN1128	Bruceine E	Others	Others
	Bruceine E 是从 B. javanica 种子中分离得到的，具有降血糖作用。 Bruceine E 可用于作为胰岛素促分泌剂的研究。
TN6771	Malabaricone B	Others	Others
	Malabaricone B 是一种源自香料的酚类物质，它通过不依赖 p53 的途径诱导肺癌细胞中的线粒体损伤。
T7052	Gnetol	Tyrosinase; COX; HDAC; AChR	Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Neuroscience; Proteases/Proteasome
	Gnetol 是从买麻藤的根中分离出来的一种酚类。它是酪氨酸酶抑制剂，对鼠酪氨酸酶的 IC50为 4.5 μM，可抑制黑色素的生物合成。它有效抑制 COX-1和 HDAC，具有抗氧化、抗增殖、抗癌和保肝活性，还具有浓度依赖性的 α-淀粉酶、α-葡萄糖苷酶和脂肪形成活性。
TN1026	Vomicine 番木虌次碱,番木鳖次碱	Others	Others
	Vomicine 是一种具有抗糖尿病活性的生物碱。
TN1403	Arjunolic acid	IL Receptor; TNF; Reactive Oxygen Species; JNK; AChE	Apoptosis; Immunology/Inflammation; MAPK; Metabolism; Neuroscience; NF-κB
	Arjunolic acid 是分离自蓝莓的皂苷，具有抗氧化、抗菌和抗炎症等多种生物活性，在保护细胞和组织免受活性氧的有害作用中发挥重要作用。
TN1644	Flavanomarein	Others	Others
	Flavanomarein 是Coreopsis tinctoria Nutt 的主要黄酮类化合物，对糖尿病性肾病具有保护作用。它具有很好的抗氧化，降糖，降压和降血脂作用。
TN1911	Marein 马里苷,马里甙	transporter; Akt; HDAC; AMPK	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling
	Marein 能通过CaMKK/AMPK/GLUT1促进葡萄糖摄取，IRS/Akt/GSK-3β增加糖原合成，并通过Akt/FoxO1减少糖异生，从而改善 HepG2 细胞中高葡萄糖诱导的胰岛素抵抗。它对甲基乙二醛诱导的 PC12 细胞损伤具有神经保护作用，还有抗氧化、降压、降血脂和抗糖尿病作用。
T0795	Rutin Quercetin 3-O-rutinoside,芦丁,Rutoside	Beta Amyloid; Prostaglandin Receptor; Autophagy	Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Rutin (Quercetin 3-O-rutinoside) 是槐果实中的一种黄酮类天然产物，具有抗炎、降糖、抗氧化、神经保护、肾脏保护、肝脏保护和降低Aβ低聚物活性等多种生物活性。它能穿过血脑屏障，通过抑制细胞凋亡、线粒体功能紊乱和氧化应激抑制万古霉素诱导的肾小管细胞凋亡。
T4723	D-Tagatose 塔格糖,D-(-)-Tagatose,D-塔格糖,d-tagatos	Others; Endogenous Metabolite	Metabolism; Others
	D-Tagatose (D-(-)-Tagatose) 是自然界中发现的一种罕见的单糖，具有益生元特性。它是研究II 型糖尿病的潜在抗糖尿病药物，也是帮助提升结肠有益细菌、预防结肠癌和抑制胆固醇的益生元。它是蔗糖的替代品，也是口香糖、果汁和饮料等食品中的低热量甜味剂。
T3S1319	(+)-Magnoflorine Escholin,Magnoflorine,Thalictrin,Escholine,木兰花碱	Others; Antifungal	Microbiology/Virology; Others
	(+)-Magnoflorine (Thalictrin) 是从 Acoruscalamus 中分到的一种阿朴啡生物碱，可以减少 C. albicans 生物膜的形成，具有抗真菌、抗氧化、抗糖尿病、镇静和抗焦虑的作用。
TL0006	Cichoric Acid 菊苣酸,Dicaffeoyltartaric acid,Chicoric Acid	Reactive Oxygen Species; HIV Protease	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Cichoric Acid (Dicaffeoyltartaric acid) 是一种天然化合物，具有抗氧化作用。
T22417	Rutin hydrate 芦丁,Rutoside,Sophorin,Quercetin-3-O-rutinoside	Beta Amyloid; Others; Autophagy	Autophagy; Neuroscience; Others
	Rutin hydrate (Sophorin) 是一种广泛存在于多种植物中的黄酮类天然产物，具有降糖、抗炎、抗氧化、神经保护、肾脏保护、肝脏保护和降低 Aβ 低聚物活性等多种生物活性。它能穿过血脑屏障，通过抑制细胞凋亡、线粒体功能紊乱和氧化应激抑制万古霉素诱导的肾小管细胞凋亡。
T3S1320	(+)-Magnoflorine iodide Magnoflorine iodide,Thalictrine iodide,碘化木兰花碱,Corytuberine Methiodide	Others; Antifungal	Microbiology/Virology; Others
	(+)-Magnoflorine iodide (Thalictrine iodide) 是从 Acoruscalamus 中分到的一种阿朴啡生物碱，具有抗炎、抗真菌、抗氧化和抗糖尿病的作用，可以减少C. albicans 生物膜的形成。
T2902	Costunolide Costus lactone,NSC 106404,Costunolid,(+)-Costunolide,木香烃内酯	Apoptosis; Endogenous Metabolite; Telomerase	Apoptosis; DNA Damage/DNA Repair; Metabolism
	Costunolide (Costus lactone) 是一种天然的倍半萜内酯，具有抗氧化、抗炎、抗过敏、骨重塑、神经保护、促进毛发生长、抗癌和抗糖尿病的特性，可诱导乳腺癌细胞周期阻滞和凋亡。
T4S1321	(+)-Magnoflorine chloride Magnoflorine chloride,氯化木兰花碱,Corytuberine methochloride,Thalictrine chloride,Escholine chloride	Others; Antifungal	Microbiology/Virology; Others
	(+)-Magnoflorine chloride (Escholine chloride) 是从 Acoruscalamus 中分到的一种阿朴啡生物碱，具有抗炎、抗真菌、抗氧化和抗糖尿病的作用，可以减少 C. albicans 生物膜的形成。
T8300	Mogroside IV-E mogroside Ive,罗汉果甙 IV	Antioxidant	oxidation-reduction
	Mogroside IV-E 是一种非糖类甜味剂，是一种三萜糖苷。Mogroside 比蔗糖更甜，具有抗氧化，抗糖尿病和抗癌作用。
T2S1194	Mogroside II-A2 罗汉果苷 II-A2	Others	Others
	Mogroside II-A2 是一种三萜糖苷，用作非糖类甜味剂，比蔗糖更甜。Mogroside 具有抗氧化，抗糖尿病和抗癌活性。
T2927	Trigonelline chloride Gynesine Hydrochloride,盐酸葫芦巴碱,Coffearine Hydrochloride,Nicotinic acid N-methylbetaine Hydrochloride,Trigonelline hydrochloride	Others; Antibacterial; Antifungal; HSV	Microbiology/Virology; Others
	Trigonelline chloride (Coffearine Hydrochloride) 是一种大量存在于咖啡中的生物碱，具有潜在抗糖尿病活性。它还具有抗HSV-1，抗菌和抗真菌活性。
TN6718	Dehydrocostuslactone	Others	Others
	Dehydrocostuslactone 是一种从奥克兰提取的天然产物。它具有广泛的生物作用，包括抗炎、抗癌、抗病毒、抗菌、抗真菌、抗氧化、抗糖尿病、抗溃疡和驱虫活性。
T2887	Trigonelline Trigenolline,葫芦巴碱	Apoptosis; Others; Ferroptosis; Endogenous Metabolite	Apoptosis; Metabolism; Others
	Trigonelline (Trigenolline) 是一种大量存在于咖啡中的生物碱，具有潜在抗糖尿病活性。它是Nrf2抑制剂，可阻断 Nrf2 依赖的蛋白酶体活性，从而增强胰腺癌细胞凋亡。
T67709	Hispolon	Others	Others
	Hispolon 是一种多酚。Hispolon 可以从林芝Phellinus linteus 中分离出来。Hispolon 具有抗癌、抗糖尿病、抗病毒、保肝、抗氧化和抗炎活性。
T3S1196	mogroside IV	Others	Others
	Mogroside IV 是一种从罗汉果提取物中分离得到的三萜糖苷。它是非糖类甜味剂，甜度比蔗糖高。它具有抗氧化，抗糖尿病和抗癌作用。
T4842	1H-pyrazole 1,2-Diazole,Pyrazole,吡唑	Others; Endogenous Metabolite	Metabolism; Others
	1H-pyrazole (1,2-Diazole) 是内源性代谢产物的一种。
TN2247	Swertisin	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Swertisin 是从日本紫菜中分离出的 C-葡萄糖基黄酮，是腺苷 A1 受体拮抗剂，具有抗糖尿病、抗炎和抗氧化作用。
TN1934	Mogroside IIA1 Mogroside II-A1,罗汉果苷II A1	Others; NO Synthase	Immunology/Inflammation; Others
	Mogroside IIA1 (Mogroside II-A1) 是从罗汉果的果实中分离得到的。Mogroside IIA1 是一种无糖甜味剂，比蔗糖更甜。 Mogroside IIA1 具有抗氧化、抗糖尿病和抗癌活性。
T8202	Kaempferol 3-O-gentiobioside Kaempferol 3-gentiobioside,山柰酚 3-龙胆双糖苷	Glucosidase	Metabolism
	Kaempferol 3-O-gentiobioside 是一种黄酮类化合物，从C. alata 叶中分离得到，具有抗糖尿病特性。它有抗 α-glucosidase 活性，并具有对碳水化合物酶的抑制作用，其 IC50=50.0 µM。
T4S0795	Berberrubine chloride 9-Berberoline Chloride,Beroline,Beroline Chloride,小檗红碱,Berberrubine,9-Berberoline	IL Receptor	Immunology/Inflammation
	Berberrubine chloride (9-Berberoline Chloride) 是一种黄连素的有效代谢物，能够改善动物模型中溃疡性结肠炎的症状。
TN1100	Nepodin	transporter; COX; AMPK; Parasite	Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling
	Nepodin 是从Rumex crispus 中分离的一种醌氧化还原酶抑制剂，具有抗糖尿病和抗疟疾的作用。。它通过激活 AMPK 刺激 GLUT4 向质膜的转运。
TN1712	Gossypin	NF-κB; S6 Kinase	MAPK; NF-κB; PI3K/Akt/mTOR signaling
	Gossypin 是一种从Hibiscus vitifolius 中分离得到的黄酮，能够抑制NF-κB 和 NF-κB 的调节基因表达。在小鼠原代骨髓细胞和 RAW264.7 细胞中，它也可抑制 RANKL 诱导的破骨细胞形成。它具有抗氧化、抗炎、抗癌、抗衰老、抗糖尿病和保护肝脏的活性。
T5S0384	Rhapontin Ponticin,土大黄苷,Rhaponiticin,Rhaponticin,Rhapontigenin glucoside	Apoptosis; Others	Apoptosis; Others
	Rhapontin (Ponticin) 是药用大黄的一种成分，可减轻KK/Ay 糖尿病小鼠肝脏脂肪变性，改善血糖和血脂，表明其具有显着的降糖作用，有望成为治疗2型糖尿病及其并发症的新药。
T6S0232	Eriodictyol 圣草酚,Huazhongilexone	Influenza Virus; DNA/RNA Synthesis; Nrf2; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology
	Eriodictyol (Huazhongilexone) 是从中草药中得到的一种黄酮类天然产物，具有抗氧化、抗炎和抗糖尿病作用。它还是一种流感依赖 RNA 的RNA 聚合酶抑制剂，IC50为 18 nM。它可诱导Nrf2信号通路。
TN1215	(2S)-2'-Methoxykurarinone 2'-甲氧基苦参黄素,2'-Methoxykurarinone,2'-O-Methylkurarinone	Akt; Antifection	Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling
	(2S)-2'-Methoxykurarinone 是一种分离自苦参根中的化合物，具有抗炎、解热、抗糖尿病和抗肿瘤活性。它对人髓系白血病 HL-60 细胞具有细胞毒活性。它能够下调 RANKL 信号，抑制破骨细胞形成和骨吸收。
TN1036	Gomisin D 戈米辛 D,戈米辛D	Others	Others
	Gomisin D 是一种分离自五味子中的木脂素。它抑制 UDP-葡糖醛酸基转移酶活性，清除 ABTS(+) 自由基。它是生脉散和参芪降糖颗粒的质量标志物，具有成为抗糖尿病药和抗阿尔茨海默病药的潜力。
TN1206	2,4,6-Trihydroxybenzaldehyde	Others	Others
	2,4,6-Trihydroxybenzaldehyde 是一种天然产物。 2,4,6-三羟基苯甲醛是一种潜在的抗肥胖治疗药物，可抑制 C57BL/6 小鼠的 3T3-L1 细胞中的脂肪细胞分化和高脂饮食诱导的脂肪积累。它也是一种有效的抗糖尿病药物。 2,4,6-三羟基苯甲醛具有潜在的抗癌活性。
T6S1597	Mulberroside A 桑皮苷 A,桑皮苷A	TNF; Tyrosinase; Interleukin	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	Mulberroside A 是桑中的一种主要活性成分，可降低TNF-α、IL-1β和IL-6的表达，抑制 NALP3、caspase-1 和 NF-κB 的激活以及 ERK、JNK 和 p38 的磷酸化。它抑制蘑菇酪氨酸酶，具有抗炎和抗细胞凋亡作用。
T6718	Zingerone Gingerone,Vanillylacetone,姜酮,NSC 15335	NF-κB	NF-κB
	Zingerone (Vanillylacetone) 是一种从生姜中得到的无毒的甲氧基苯酚，具有抗炎、抗糖尿病、抗脂质过敏、抗腹泻、抗痉挛和抗肿瘤等活性。它作为抗有丝分裂剂，能够抑制神经母细胞瘤的生长。它能够缓解氧化应激和炎症，下调 NF-κB 介导的信号通路。
TN6926	Paeonoside	Others	Others
	Paeonoside 发现与P. suffruticosa 中，具有生物活性，可以促进成骨细胞分化过程中的伤口愈合和迁移。Paeonoside 具有一定的抗糖尿病活性，可防止脓毒症和败血症引起的死亡。Paeonoside 对 MC3T3-E1细胞的前成骨细胞没有细胞毒性作用，以剂量依赖性的方式显著恢复伤口区域并促进细胞迁移和促进碱性磷酸酶（ALP）染色及其活性。
TJS0387	Desoxyrhaponticin 去氧土大黄苷,Deoxyrhapontin,脱氧土大黄苷,Deoxyrhaponticin	Apoptosis; Fatty Acid Synthase	Apoptosis; Metabolism
	Desoxyrhaponticin (Deoxyrhaponticin) 是来自西藏营养食品唐古特大黄中的一种二苯乙烯苷。它是脂肪酸合成酶抑制剂，抑制细胞内 FAS 活性，下调人乳腺癌 MCF-7细胞中 FAS 的表达。它是控制糖尿病餐后高血糖的潜在药物。
TN2095	Pomiferin	NOS; NF-κB; PDE	Immunology/Inflammation; Metabolism; NF-κB
	Pomiferin is a natural product inhibitor of carbonic anhydrase I and II isoenzymes. It has anticancer, antibacterial and antidiabetic properties. Pomiferin has anti-inflammatory and neuroprotective activities.
T68746	Chaetochromin
	Chaetochromin also known as 4548-G05 and NSC 345647, is an orally active, small-molecule, selective agonist of the insulin receptor. It has potent and long-lasting antidiabetic activity in vivo in mice.
TN1945	Momordicoside K	Others	Others
	Momordicoside K has antidiabetic activity.
TN4576	Momordicine II	Others	Others
	Momordicine II may have antidiabetic activity, it significantly stimulated insulin secretion. It also can deter oviposition by L. trifolii significantly.
T39219	Ficusonolide
	Ficusonolide exhibits significant antidiabetic activity through its interactions with dipeptidyl peptidase-IV (DPP-IV), protein tyrosine phosphatase 1B (PTP-1B), α-glucosidase, and α-amylase.
TN2045	Pelargonidin-3-O-glucoside chloride	Others; Estrogen/progestogen Receptor	Endocrinology/Hormones; Others
	Pelargonidin-3-O-glucopyranoside is the glucoside of Pelargonidin, an potential antidiabetic agent. Pelargonidin-3-O-glucopyranoside has antioxidant, anti-inflammatory, anti-estrogenic, and angiotensin-converting enzyme inhibitory activities.
TN1462	Cajanin 2',4',5-三羟基-7-甲氧基异黄酮,木豆异黄酮	ERK; MEK; Akt	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol efflux and RCT, it can significantly improve basal glucose uptake in HepG2 cells, its improving effect is concentration dependent, it exhibits effects stronger than that of rosiglitazone, which has been used as an antidiabetic drug.
T3930	Taraxerol acetate 醋酸蒲公英霜,Taraxeryl acetate	Phosphatase; HSV	Metabolism; Microbiology/Virology
	Taraxeryl acetate shows the significant antiviral activity against herpes simplex virus (type II). It has less effect on cell cycle arrest and apoptosis of AGS cells than taraxerol. A. roxburghiana has antidiabetic activity, could be attributed due to PTP
T12089	Mogroside I A1 罗汉果苷 I A1	Others	Others
	Mogroside I A1 是一种非糖类甜味剂，是三萜糖苷。Mogroside 比蔗糖更甜，具有抗氧化，抗糖尿病和抗癌作用。
T80008	Stevisaliosides D	Phosphatase	Metabolism
	Stevisaliosides D (Compound 5) 是从甜叶菊根中提取的化合物，具有抑制PTP1B的活性（IC50：31.8 μM），应用于抗糖尿病研究。
TMA0127	Ficusin A	transporter; PPAR	DNA Damage/DNA Repair; Metabolism
	Ficusin has antioxidant, antilipidemic and antidiabetic effects, it can lower the levels of fasting blood glucose, plasma insulin, body weight gain in HFD-STZ induced diabetic rats, and can significantly enhance the PPARγ expression and improve the transl
T83562	(2R)-Flavanomarein
	(2R)-Flavanomarein为Coreopsis tinctoria Nutt的黄酮主要成分，具备糖尿病性肾病防护功能。该化合物展现出显著的抗氧化、降血糖、降血压及降低血脂的活性。
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天然产物

Cat.No: TN1128

Target: Others

Cat.No: TN6771

Target: Others

Cat.No: T7052

Target: Tyrosinase, COX, HDAC, AChR

Cat.No: TN1026

Synonym: 番木虌次碱,番木鳖次碱

Target: Others

Cat.No: TN1403

Target: IL Receptor, TNF, Reactive Oxygen Species, JNK, AChE

Cat.No: TN1644

Target: Others

Cat.No: TN1911

Synonym: 马里苷,马里甙

Target: transporter, Akt, HDAC, AMPK

Cat.No: T0795

Synonym: Quercetin 3-O-rutinoside,芦丁,Rutoside

Target: Beta Amyloid, Prostaglandin Receptor, Autophagy

Cat.No: T4723

Synonym: 塔格糖,D-(-)-Tagatose,D-塔格糖,d-tagatos

Target: Others, Endogenous Metabolite

(+)-Magnoflorine

Cat.No: T3S1319

Synonym: Escholin,Magnoflorine,Thalictrin,Escholine,木兰花碱

Target: Others, Antifungal

Cat.No: TL0006

Synonym: 菊苣酸,Dicaffeoyltartaric acid,Chicoric Acid

Target: Reactive Oxygen Species, HIV Protease

Cat.No: T22417

Synonym: 芦丁,Rutoside,Sophorin,Quercetin-3-O-rutinoside

Target: Beta Amyloid, Others, Autophagy

(+)-Magnoflorine iodide

Cat.No: T3S1320

Synonym: Magnoflorine iodide,Thalictrine iodide,碘化木兰花碱,Corytuberine Methiodide

Target: Others, Antifungal

Cat.No: T2902

Synonym: Costus lactone,NSC 106404,Costunolid,(+)-Costunolide,木香烃内酯

Target: Apoptosis, Endogenous Metabolite, Telomerase

(+)-Magnoflorine chloride

Cat.No: T4S1321

Synonym: Magnoflorine chloride,氯化木兰花碱,Corytuberine methochloride,Thalictrine chloride,Escholine chloride

Target: Others, Antifungal

Cat.No: T8300

Synonym: mogroside Ive,罗汉果甙 IV

Target: Antioxidant

Mogroside II-A2

Cat.No: T2S1194

Synonym: 罗汉果苷 II-A2

Target: Others

Trigonelline chloride

Cat.No: T2927

Synonym: Gynesine Hydrochloride,盐酸葫芦巴碱,Coffearine Hydrochloride,Nicotinic acid N-methylbetaine Hydrochloride,Trigonelline hydrochloride

Target: Others, Antibacterial, Antifungal, HSV

Dehydrocostuslactone

Cat.No: TN6718

Target: Others

Cat.No: T2887

Synonym: Trigenolline,葫芦巴碱

Target: Apoptosis, Others, Ferroptosis, Endogenous Metabolite

Cat.No: T67709

Target: Others

Cat.No: T3S1196

Target: Others

Cat.No: T4842

Synonym: 1,2-Diazole,Pyrazole,吡唑

Target: Others, Endogenous Metabolite

Cat.No: TN2247

Target: Adenosine Receptor

Cat.No: TN1934

Synonym: Mogroside II-A1,罗汉果苷II A1

Target: Others, NO Synthase

Kaempferol 3-O-gentiobioside

Cat.No: T8202

Synonym: Kaempferol 3-gentiobioside,山柰酚 3-龙胆双糖苷

Target: Glucosidase

Berberrubine chloride

Cat.No: T4S0795

Synonym: 9-Berberoline Chloride,Beroline,Beroline Chloride,小檗红碱,Berberrubine,9-Berberoline

Target: IL Receptor

Cat.No: TN1100

Target: transporter, COX, AMPK, Parasite

Cat.No: TN1712

Target: NF-κB, S6 Kinase

Cat.No: T5S0384

Synonym: Ponticin,土大黄苷,Rhaponiticin,Rhaponticin,Rhapontigenin glucoside

Target: Apoptosis, Others

Cat.No: T6S0232

Synonym: 圣草酚,Huazhongilexone

Target: Influenza Virus, DNA/RNA Synthesis, Nrf2, Endogenous Metabolite

(2S)-2'-Methoxykurarinone

Cat.No: TN1215

Synonym: 2'-甲氧基苦参黄素,2'-Methoxykurarinone,2'-O-Methylkurarinone

Target: Akt, Antifection

Cat.No: TN1036

Synonym: 戈米辛 D,戈米辛D

Target: Others

2,4,6-Trihydroxybenzaldehyde

Cat.No: TN1206

Target: Others

Cat.No: T6S1597

Synonym: 桑皮苷 A,桑皮苷A

Target: TNF, Tyrosinase, Interleukin

Cat.No: T6718

Synonym: Gingerone,Vanillylacetone,姜酮,NSC 15335

Target: NF-κB

Cat.No: TN6926

Target: Others

Desoxyrhaponticin

Cat.No: TJS0387

Synonym: 去氧土大黄苷,Deoxyrhapontin,脱氧土大黄苷,Deoxyrhaponticin

Target: Apoptosis, Fatty Acid Synthase

Cat.No: TN2095

Target: NOS, NF-κB, PDE

Cat.No: T68746

Momordicoside K

Cat.No: TN1945

Target: Others

Cat.No: TN4576

Target: Others

Cat.No: T39219

Pelargonidin-3-O-glucoside chloride

Cat.No: TN2045

Target: Others, Estrogen/progestogen Receptor

Cat.No: TN1462

Synonym: 2',4',5-三羟基-7-甲氧基异黄酮,木豆异黄酮

Target: ERK, MEK, Akt

Taraxerol acetate

Cat.No: T3930

Synonym: 醋酸蒲公英霜,Taraxeryl acetate

Target: Phosphatase, HSV

Cat.No: T12089

Synonym: 罗汉果苷 I A1

Target: Others

Stevisaliosides D

Cat.No: T80008

Target: Phosphatase

Cat.No: TMA0127

Target: transporter, PPAR

(2R)-Flavanomarein

Cat.No: T83562

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