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Search Results for " vegfr-1 "
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93

抑制剂 & 化合物

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Cat. No. Product Name Target Signaling Pathways
T23504 VEGFR-IN-1

VEGFR Tyrosine Kinase Inhibitor II

Others Others
VEGFR inhibitor
T12598 Pz-1

VEGFR; c-RET Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
Pz-1VEGFR2 和 RET 酪氨酸激酶的抑制剂,可阻断 RET 刺激生长所需的血液供应。
T72924 VEGFR-3-IN-1

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
VEGFR-3-IN-1 是一种新型有效且具有选择性的 VEGFR3 抑制剂,其 IC50 为 110.4 nM。VEGFR-3-IN-1 具有抗肿瘤活性,可使 VEGFR3 信号通路失活,可抑制 VEGF-C 诱导人真皮淋巴管内皮细胞 (HDLEC)、MDA-MB-231 和 MDA-MB-436 细胞的增殖和迁移,并且能有效抑制乳腺癌的生长。
T8817 TIE-2/VEGFR-2 kinase-IN-1

TIE-2/VEGFR-2 kinase-IN-1 用于合成TIE-2或者VEGFR-2抑制剂,可用于研究不适当的血管生成的相关疾病。
T4288 hVEGF-IN-1

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
hVEGF-IN-1 是一种喹唑啉衍生物,可以特异性结合内部核糖体进入位点 A 中富含 G 的序列,并会使 G-四链体结构不稳定。在 SPR 实验中,它与 IRES-A (WT) 结合的Kd 值为 0.928 μM。它能够抑制VEGF-A 蛋白表达,阻止肿瘤细胞迁移,抑制肿瘤生长。
T5466 Tyrosine kinase-IN-1

VEGFR; FGFR; FLT; PDGFR Angiogenesis; Tyrosine Kinase/Adaptors
Tyrosine kinase-IN-1是一种多靶点酪氨酸激酶抑制剂,能够抑制KDR (IC50:4 nM),Flt-1 (IC50:20 nM),FGFR1 (IC50:4 nM) 和 PDGFRα (IC50:2 nM)。
T3566 SU5205

SU 5205

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
SU5205 是一种 VEGFR2 (FLK-1) 的抑制剂,其IC50=9.6 μM。
T5475 ZD-4190

EGFR; VEGFR Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
ZD-4190 是血管内皮细胞生长因子受体 2 (VEGFR2) 和表皮生长因子受体 (EGFR) 信号传导的抑制剂,用于治疗癌症。
T3569 SU5214

SU 5214

VEGFR; Tyrosinase Angiogenesis; Proteases/Proteasome; Tyrosine Kinase/Adaptors
SU5214 (SU 5214) 是 VEGFR2 抑制剂,IC50值为 14.8 µM(FLK-1) 和 36.7 µM (EGFR)。
T2624 OSI-930

OSI 930,噻尔非尼

Apoptosis; c-Fms; Raf; VEGFR; FLT; CSF-1R; Src; c-Kit Angiogenesis; Apoptosis; MAPK; Tyrosine Kinase/Adaptors
OSI-930 是 Kit,KDR 和 CSF-1R (c-Fms)的口服选择性抑制剂,IC50分别为 80 nM,9 nM 和 15 nM。它具有抗肿瘤活性,靶向肿瘤中的癌细胞增殖和血管生成。它还适度抑制 Flt-1,c-Raf 和 Lck,并且对 PDGFRα/β,Flt-3和 Abl 具有较弱的抑制活性。
T5194 SPHINX31

Serine/threonin kinase Cell Cycle/Checkpoint; Metabolism
SPHINX31 是丝氨酸/富含精氨酸的蛋白激酶1的选择性抑制剂,其IC50值为 5.9 nM。它有效抑制丝氨酸/丰富精氨酸的剪接因子1 磷酸化,有用于局部新生血管性眼病的研究潜力。
T5349 SCR-1481B1

麦他替尼胺丁三醇,c-Met inhibitor 2

VEGFR; c-Met/HGFR Angiogenesis; Tyrosine Kinase/Adaptors
SCR-1481B1 (c-Met inhibitor 2) 能够作用于依赖 Met 激活的癌症,对 VEGFR 具有抑制作用。
T2032 WHI-P180

Janex 3

EGFR; VEGFR; c-RET; CDK Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; JAK/STAT signaling; Tyrosine Kinase/Adaptors
WHI-P180 (Janex 3) 是 EGFR 和 Cdk2 抑制剂,IC50 分别为 4.0 和 1.0 μM。
T4315 Ki20227

N-[4-[(6,7-二甲氧基-4-喹啉基)氧基]-2-甲氧基苯基]-N'-[1-(2-噻唑基)乙基]脲

c-Fms; VEGFR; CSF-1R; PDGFR; c-Kit Angiogenesis; Tyrosine Kinase/Adaptors
Ki20227 是一种高效的、口服具有活性的、选择性的CSF1R(c-Fms 酪氨酸激酶)抑制剂,对 CSF1R,VEGFR2,c-Kit 和PDGFRβ的IC50分别为 2 nM,12 nM,451 nM 和 217 nM。它可以阻止破骨细胞分化和溶骨性破坏。
T35570 Chiauranib

CS2164,西奥罗尼

c-Fms; VEGFR; FLT; PDGFR; c-Kit; Aurora Kinase Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
Chiauranib 是一种针对肿瘤血管生成的多靶点抑制剂,具有强大的抗癌作用。 Chiauranib 有效抑制血管生成相关激酶(VEGFR1VEGFR2、VEGFR3、PDGFRα 和 c-Kit)、有丝分裂相关激酶 Aurora B 和慢性炎症相关激酶 CSF1R,IC50 值范围为 1-9 nM。
T0374L Sunitinib

苏尼替尼,舒尼替尼,SU 11248

Apoptosis; Mitophagy; VEGFR; FLT; IRE1; PDGFR; c-Kit; Autophagy Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
Sunitinib (SU 11248) 是一种多靶点受体酪氨酸激酶 (RTK) 抑制剂,可以抑制 VEGFR2 和 PDGFRβ (IC50=80/2 nM)。Sunitinib 具有抗肿瘤活性,可以用于治疗肾癌和胃肠道肿瘤。
T22431 SU5204

3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one

EGFR; VEGFR; HER Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
SU5204 (3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one) 是酪氨酸激酶抑制剂,是 SU5025 的类似物,对 FLK-1 (VEGFR-2) 和 HER2 的IC50分别为 4 和 51.5 μM。
T6823 E3330

HIF/HIF Prolyl-Hydroxylase; DNA/RNA Synthesis Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
E3330 是一种口服有效的选择性 AP 内切核酸酶 1 (APE1; REF-1) 抑制剂,可抑制NF-κB DNA 结合活性。它阻断 TNF-α 诱导的肝癌细胞系中 IL-8 的激活,可以抑制癌细胞的生长和迁移,具有抗癌活性。
T12574 PTC299

Emvododstat,(4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate

VEGFR; Dehydrogenase Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
PTC299 ((4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) 是一种口服活性的 VEGFA mRNA 翻译抑制剂,可选择性地抑制转录后水平的 VEGF 蛋白合成。它还是二氢乳酸脱氢酶 (DHODH) 的有效抑制剂,可研究血液系统恶性肿瘤。
T79647 VEGFR/PARP-IN-1

PARP Chromatin/Epigenetic; DNA Damage/DNA Repair
VEGFR/PARP-IN-1 (Compound 14b) 是一款针对VEGFR和PARP两个靶点的双重抑制剂,其对VEGFR和PARP的IC50值分别为191 nM和60.9 nM。该化合物能够抑制DNA损伤修复机制,诱导apoptosis,并使细胞在G2/M期阻滞。此外,VEGFR/PARP-IN-1对BRCA野生型乳腺癌细胞表现出较强的抗增殖效果,尤其是在MDA-MB-231和MCF-7细胞系上,其IC50值分别为4.1 μM和3.5 μM,是潜在的抗肿瘤和抗转移药物。
T7186 CZC-8004

CZC-00008004,N2-(4-(氨甲基)苯)-5-氟-N4-苯基嘧啶-2,4-二胺

Bcr-Abl Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
CZC-8004 (CZC-00008004) 是广泛的激酶抑制剂,可与包括 ABL 激酶在内的多种酪氨酸激酶结合,。
TQ0166 Tesevatinib

KD-019,XL-647,EXEL-7647

EGFR; VEGFR; FLT; Ephrin Receptor Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Tesevatinib (XL-647) 是一种口服的多靶点酪氨酸激酶抑制剂,对 EGFR、ErbB2、KDR、Flt4和 EphB4的 IC50值分别为 0.3、16、1.5、8.7和 1.4 nM。
T79540 hCA/VEGFR-2-IN-1

Carbonic Anhydrase Metabolism
hCA/VEGFR-2-IN-1 是一种高效的双靶点抑制剂,对 hCA IX 和 hCA XII 两种碳酸酐酶(CA)具有极低的Ki值,分别为8.3 nM和4.7 nM。同时,hCA/VEGFR-2-IN-1 也是一种有效的 VEGFR-2 抑制剂,其 IC50 值仅为26.3 nM,并且显示出抗癌活性。
T0374 Sunitinib Malate

苏尼替尼苹果酸盐,Sutent,SU 11248 (Malate),SU 11248,Sunitinib

Apoptosis; Mitophagy; VEGFR; FLT; IRE1; PDGFR; c-Kit; Autophagy Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
Sunitinib Malate (Sunitinib) 是一种基于吲哚酮的酪氨酸激酶抑制剂,抑制 VEGFR2和 PDGFRβ的 IC50分别为80 nM 和 2 nM。它是 ATP 竞争性抑制剂,可通过抑制自身磷酸化和随后的 RNase 激活来有效抑制 Ire1α的磷酸化。
T74517 PROTAC VEGFR-2 degrader-1

PROTACVEGFR-2 degrader-1(PROTAC-1),一种 PROTACVEGFR-2降解剂,对 VEGFR-2 的抑制作用很小(IC50> 1 μM),对 EA.hy926 细胞的抗增殖活性也很低(IC50> 100μM)。
T72607 VEGFR-2/BRAF-IN-1

VEGFR-2/BRAF-IN-1 是一种 VEGFR-2和 BRAF 双重抑制剂,对 VEGFR-2、BRAFV600E 和BRAFWT 的IC50分别为 0.049、0.063 和 0.005 µM。VEGFR-2/BRAF-IN-1 诱导细胞凋亡,在 G1/S 期阻滞细胞周期。
T61489 VEGFR-2/DHFR-IN-1

VEGFR-2/DHFR-IN-1 (compound 8b) 是 VEGFR-2和DHFR 的抑制剂,其IC50值分别为 0.384 和 7.881 μM。VEGFR-2/DHFR-IN-1 对大肠埃希菌,粪链球菌,肠沙门氏菌,金黄色酿脓葡萄球菌,MSSA 和MRSA 显示了良好的抗菌活性,MIC 值分别为 16,16,16,8 和 16 μg/mL。VEGFR-2/DHFR-IN-1 对 C26,HepG2 和 CF7 癌细胞系具有良好的细胞毒性,IC50值为 2.97-7.12 μM。VEGFR-2/DHFR-IN-1 可用于癌症的研究。
T6930 Pazopanib Hydrochloride

GW786034,Pazopanib HCl,GW786034 HCl,盐酸帕唑帕尼,Votrient HCl,Armala

c-Fms; VEGFR; FGFR; PDGFR; c-Kit; Autophagy Angiogenesis; Autophagy; Tyrosine Kinase/Adaptors
Pazopanib Hydrochloride (Votrient HCl) 是一种多靶点抑制剂,抑制 VEGFR1VEGFR2、VEGFR3、PDGFRβ、c-Kit、FGFR1和c-Fms 的IC50分别为10、30、47、84、74、140和146 nM。
T2514 Linifanib

利尼伐尼,ABT-869,RG3635,AL-39324

Apoptosis; c-Fms; VEGFR; FLT; CSF-1R; PDGFR; c-Kit; Autophagy Angiogenesis; Apoptosis; Autophagy; Tyrosine Kinase/Adaptors
Linifanib (AL-39324) 是一种高效口服的VEGFR 和PDGFR 家族多靶点抑制剂,具有显著的抗肿瘤活性。它对无关 RTKs、可溶性酪氨酸激酶或丝氨酸/苏氨酸激酶的活性要低得多。它是特异性 miR-10b 抑制剂,阻断miR-10b 的生物合成。
T6289 Dovitinib

TKI258,多韦替尼,CHIR-258,度维替尼

VEGFR; FGFR; FLT; PDGFR; c-Kit Angiogenesis; Tyrosine Kinase/Adaptors
Dovitinib (CHIR-258) 是一种口服有效的、多靶点的酪氨酸激酶 (RTK) 抑制剂,具有抗肿瘤作用。
T5164 Cabozantinib hydrochloride

XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351,盐酸卡博替尼

VEGFR; FLT; c-Met/HGFR; TAM Receptor; c-Kit; ROR Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
Cabozantinib hydrochloride (XL184) 是一种有效的泛酪氨酸激酶抑制剂,可抑制 VEGFR2、c-Met、Kit、Axl 和 Flt4(IC50:0.035、1.3、4.6、7 和 6 nM)。
T80874 VEGFR-2/c-Met-IN-1

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
VEGFR-2/c-Met-IN-1VEGFR-2及c-Met的双重抑制剂,IC50值为138 nM和74 nM,显示出抗肿瘤活性。
T6028 PF 477736

PF 00477736,PF-477736,PF-736,PF-00477736,PF477736

c-Fms; VEGFR; FGFR; FLT; c-RET; Chk; CDK; Src; Aurora Kinase Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
PF 477736 (PF-736,PF-00477736) 是一种特异性、有效且具有 ATP 竞争性的 Chk1 抑制剂,Ki 值为0.49 nM。它也是Chk2抑制剂,Ki 值为 47 nM。它还抑制VEGFR2、Fms、Yes、Aurora-A、FGFR3、Flt3和Ret。
T4349 Sitravatinib

MG516,MGCD516

Discoidin Domain Receptor (DDR); VEGFR; FLT; Trk receptor; TAM Receptor; c-Kit; Ephrin Receptor Angiogenesis; Tyrosine Kinase/Adaptors
Sitravatinib (MGCD516) 是一种有口服活性的受体酪氨酸激酶抑制剂。它单独使用即具有有效的抗肿瘤功效,且通过促进抗肿瘤免疫微环境增强了 PD-1 阻断的活性。
T14677 BMS-690514

EGFR; VEGFR; HER Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
BMS-690514是可口服的EGFR 和VEGFR 抑制剂,对于EGFR、HER2和HER4的IC50值分别为5、9 和 60 nM。
T2496 (Z)-Semaxinib

SU5416

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
(Z)-Semaxinib (SU5416) 是一种有效的选择性 VEGFR(Flk-1/KDR) 抑制剂 (IC50: 1.23 μM),对 VEGFR 的选择性是 PDGFRβ 的 20 倍,对 FGFR、InsR 和 EGFR 没有抑制作用。 Semaxanib 是一种具有潜在抗肿瘤活性的喹诺酮衍生物。
T63505 Tivozanib hydrochloride hydrate

Tivozanib hydrochloride hydrate 是选择性的、有效的、口服具有活力的 VEGFR 酪氨酸激酶抑制剂,能够作用于 VEGFR-1 (IC50: 0.21 nM)、VEGFR-2 (IC50: 0.16 nM)、VEGFR-3 (IC50: 0.24 nM)。Tivozanib hydrochloride hydrate 能够抑制肿瘤组织中的血管生成和血管通透性,并具有抗肿瘤作用,对转移性肾细胞癌 (RCC) 具有研究潜力。
T11153 EG00229

Others Others
EG00229 selectively inhibits VEGF-A binding to NRP1 b1 domain with an IC50 of 3 μM, but has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. EG00229 is a neuropilin 1 (NRP1) receptor antagonist.
T3463 NVP-ACC789

ACC-789,ZK202650

VEGFR; PDGFR Angiogenesis; Tyrosine Kinase/Adaptors
NVP-ACC789 (ZK202650) 是一种人VEGFR-1VEGFR-2(鼠VEGFR-2),VEGFR-3 和 PDGFR-β 的抑制剂,它们的 IC50 值分别为 0.38,0.02 (0.23),0.18 和 1.4 μM。
T13238 Tyrphostin AG1433

SU1433,AG1433

VEGFR; PDGFR Angiogenesis; Tyrosine Kinase/Adaptors
Tyrphostin AG1433 (AG1433) 是选择性的PDGFRβ和VEGFR-2 (Flk-1/KDR)抑制剂,IC50分别为 5.0 μM 和 9.3 μM。Tyrphostin AG1433有防止血管形成的活性。
T6036 Brivanib

BMS-540215,布立尼布

EGFR; VEGFR; FGFR; Autophagy Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
Brivanib (BMS-540215) 是一种针对 VEGFR2 的 ATP 竞争性抑制剂,IC50 为 25 nM。它对 VEGFR-1 和 FGFR-1 具有中等效力,对 VEGFR2 的选择性是对 PDGFR-β 的 240 倍。
T37078 VEGFR-2-IN-6

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
VEGFR-2-IN-6(WO 02/059110)是一种 VEGFR2 的强效抑制剂,这是一种在血管生成调控中起关键作用的受体[1]。
T13178 Toceranib

托西尼布,PHA 291639E,SU11654

VEGFR; PDGFR; c-Kit Angiogenesis; Tyrosine Kinase/Adaptors
Toceranib (PHA 291639E) 是口服具有活力的受体酪氨酸激酶 (RTK) 抑制剂,能有效抑制PDGFR,VEGFR,Kit,抑制 PDGFRβ 和 Flk-1/KDR 的Ki 分别为 5 nM 和 6 nM。它具有抗肿瘤和抗血管生成作用,用于研究犬肥大细胞肿瘤。
T16909 Sorafenib-d3

Sorafenib (D3),Bay 43-9006 (D3)

Raf; VEGFR Angiogenesis; MAPK; Tyrosine Kinase/Adaptors
Sorafenib-d3 (Bay 43-9006 (D3)) 是一种氘标记的 Sorafenib,Sorafenib 是一种多激酶抑制剂(对 Raf-1、B-Raf 和 VEGFR-3 的 IC50 分别为 6 nM、20 nM 和 22 nM)。
T0093 Sorafenib tosylate

甲苯磺酸索拉非尼,Bay 43-9006

Apoptosis; Raf; VEGFR; FLT; Ferroptosis; PDGFR; c-Kit; Autophagy Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors
Sorafenib tosylate (Bay 43-9006) 是一种口服活性Raf 抑制剂,也是铁死亡激动剂。它是多激酶抑制剂,对VEGFR2,VEGFR3,PDGFRβ,FLT3和c-Kit 的IC50分别为 90 nM,15 nM,20 nM,57 nM 和 58 nM。它诱导细胞自噬和凋亡,有抗肿瘤活性。
T2064 Semaxinib

司马沙尼,SU5416

VEGFR Angiogenesis; Tyrosine Kinase/Adaptors
Semaxinib (SU5416) 是一种选择性的 VEGFR(Flk-1/KDR) 抑制剂,其 IC50=1.23 μM。
T3570 SU4312

SU 4312,NSC 86429

VEGFR; PDGFR Angiogenesis; Tyrosine Kinase/Adaptors
NSC-86429 是一种 (Z)-SU4312 (SU 4312) 和 (E)-SU4312 的外消旋体。其中(Z)-SU4312 能够抑制 PDGFR 和 FLK-1。(E)-SU4312 能够抑制 PDGFR, FLK-1, EGFR, HER-2, 和 IGF-1R。
T2456 Tivozanib

替沃扎尼,AV-951,KRN951

VEGFR; PDGFR; Ephrin Receptor Angiogenesis; Tyrosine Kinase/Adaptors
Tivozanib (KRN951) 是一种选择性的 VEGFR 1/2/3抑制剂,它们的 IC50值分别为0.21 nM、0.16 nM、0.24 nM。
T0097L Pazopanib

帕唑帕尼,GW786034

VEGFR; FGFR; PDGFR; c-Kit; Autophagy Angiogenesis; Autophagy; Tyrosine Kinase/Adaptors
Pazopanib (GW786034) 是一种小分子抑制剂,可抑制多种具有潜在抗肿瘤活性的蛋白酪氨酸激酶。它抑制VEGFR1VEGFR2、VEGFR3、PDGFRβ、c-Kit、FGFR1和c-Fms 的IC50分别为10、30、47、84、74、140和146 nM。
T2500 Cediranib

AZD2171,NSC-732208,西地尼布

VEGFR; FLT; PDGFR; c-Kit; Autophagy Angiogenesis; Autophagy; Tyrosine Kinase/Adaptors
Cediranib (AZD2171) 是一种可口服的高选择性VEGFR2抑制剂,对Flt1、KDR、Flt4、PDGFRα、PDGFRβ和c-Kit 的IC50值分别为小于1、小于3、5、5、36和 2nM。

化合物

VEGFR-IN-1
Cat.No: T23504
Synonym: VEGFR Tyrosine Kinase Inhibitor II
Target: Others
Pz-1
Cat.No: T12598
Synonym:
Target: VEGFR, c-RET
VEGFR-3-IN-1
Cat.No: T72924
Synonym:
Target: VEGFR
TIE-2/VEGFR-2 kinase-IN-1
Cat.No: T8817
Synonym:
Target:
hVEGF-IN-1
Cat.No: T4288
Synonym:
Target: VEGFR
Tyrosine kinase-IN-1
Cat.No: T5466
Synonym:
Target: VEGFR, FGFR, FLT, PDGFR
SU5205
Cat.No: T3566
Synonym: SU 5205
Target: VEGFR
ZD-4190
Cat.No: T5475
Synonym:
Target: EGFR, VEGFR
SU5214
Cat.No: T3569
Synonym: SU 5214
Target: VEGFR, Tyrosinase
OSI-930
Cat.No: T2624
Synonym: OSI 930,噻尔非尼
Target: Apoptosis, c-Fms, Raf, VEGFR, FLT, CSF-1R, Src, c-Kit
SPHINX31
Cat.No: T5194
Synonym:
Target: Serine/threonin kinase
SCR-1481B1
Cat.No: T5349
Synonym: 麦他替尼胺丁三醇,c-Met inhibitor 2
Target: VEGFR, c-Met/HGFR
WHI-P180
Cat.No: T2032
Synonym: Janex 3
Target: EGFR, VEGFR, c-RET, CDK
Ki20227
Cat.No: T4315
Synonym: N-[4-[(6,7-二甲氧基-4-喹啉基)氧基]-2-甲氧基苯基]-N'-[1-(2-噻唑基)乙基]脲
Target: c-Fms, VEGFR, CSF-1R, PDGFR, c-Kit
Chiauranib
Cat.No: T35570
Synonym: CS2164,西奥罗尼
Target: c-Fms, VEGFR, FLT, PDGFR, c-Kit, Aurora Kinase
Sunitinib
Cat.No: T0374L
Synonym: 苏尼替尼,舒尼替尼,SU 11248
Target: Apoptosis, Mitophagy, VEGFR, FLT, IRE1, PDGFR, c-Kit, Autophagy
SU5204
Cat.No: T22431
Synonym: 3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one
Target: EGFR, VEGFR, HER
E3330
Cat.No: T6823
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, DNA/RNA Synthesis
PTC299
Cat.No: T12574
Synonym: Emvododstat,(4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate
Target: VEGFR, Dehydrogenase
VEGFR/PARP-IN-1
Cat.No: T79647
Synonym:
Target: PARP
CZC-8004
Cat.No: T7186
Synonym: CZC-00008004,N2-(4-(氨甲基)苯)-5-氟-N4-苯基嘧啶-2,4-二胺
Target: Bcr-Abl
Tesevatinib
Cat.No: TQ0166
Synonym: KD-019,XL-647,EXEL-7647
Target: EGFR, VEGFR, FLT, Ephrin Receptor
hCA/VEGFR-2-IN-1
Cat.No: T79540
Synonym:
Target: Carbonic Anhydrase
Sunitinib Malate
Cat.No: T0374
Synonym: 苏尼替尼苹果酸盐,Sutent,SU 11248 (Malate),SU 11248,Sunitinib
Target: Apoptosis, Mitophagy, VEGFR, FLT, IRE1, PDGFR, c-Kit, Autophagy
PROTAC VEGFR-2 degrader-1
Cat.No: T74517
Synonym:
Target:
VEGFR-2/BRAF-IN-1
Cat.No: T72607
Synonym:
Target:
VEGFR-2/DHFR-IN-1
Cat.No: T61489
Synonym:
Target:
Pazopanib Hydrochloride
Cat.No: T6930
Synonym: GW786034,Pazopanib HCl,GW786034 HCl,盐酸帕唑帕尼,Votrient HCl,Armala
Target: c-Fms, VEGFR, FGFR, PDGFR, c-Kit, Autophagy
Linifanib
Cat.No: T2514
Synonym: 利尼伐尼,ABT-869,RG3635,AL-39324
Target: Apoptosis, c-Fms, VEGFR, FLT, CSF-1R, PDGFR, c-Kit, Autophagy
Dovitinib
Cat.No: T6289
Synonym: TKI258,多韦替尼,CHIR-258,度维替尼
Target: VEGFR, FGFR, FLT, PDGFR, c-Kit
Cabozantinib hydrochloride
Cat.No: T5164
Synonym: XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351,盐酸卡博替尼
Target: VEGFR, FLT, c-Met/HGFR, TAM Receptor, c-Kit, ROR
VEGFR-2/c-Met-IN-1
Cat.No: T80874
Synonym:
Target: VEGFR
PF 477736
Cat.No: T6028
Synonym: PF 00477736,PF-477736,PF-736,PF-00477736,PF477736
Target: c-Fms, VEGFR, FGFR, FLT, c-RET, Chk, CDK, Src, Aurora Kinase
Sitravatinib
Cat.No: T4349
Synonym: MG516,MGCD516
Target: Discoidin Domain Receptor (DDR), VEGFR, FLT, Trk receptor, TAM Receptor, c-Kit, Ephrin Receptor
BMS-690514
Cat.No: T14677
Synonym:
Target: EGFR, VEGFR, HER
(Z)-Semaxinib
Cat.No: T2496
Synonym: SU5416
Target: VEGFR
Tivozanib hydrochloride hydrate
Cat.No: T63505
Synonym:
Target:
EG00229
Cat.No: T11153
Synonym:
Target: Others
NVP-ACC789
Cat.No: T3463
Synonym: ACC-789,ZK202650
Target: VEGFR, PDGFR
Tyrphostin AG1433
Cat.No: T13238
Synonym: SU1433,AG1433
Target: VEGFR, PDGFR
Brivanib
Cat.No: T6036
Synonym: BMS-540215,布立尼布
Target: EGFR, VEGFR, FGFR, Autophagy
VEGFR-2-IN-6
Cat.No: T37078
Synonym:
Target: VEGFR
Toceranib
Cat.No: T13178
Synonym: 托西尼布,PHA 291639E,SU11654
Target: VEGFR, PDGFR, c-Kit
Sorafenib-d3
Cat.No: T16909
Synonym: Sorafenib (D3),Bay 43-9006 (D3)
Target: Raf, VEGFR
Sorafenib tosylate
Cat.No: T0093
Synonym: 甲苯磺酸索拉非尼,Bay 43-9006
Target: Apoptosis, Raf, VEGFR, FLT, Ferroptosis, PDGFR, c-Kit, Autophagy
Semaxinib
Cat.No: T2064
Synonym: 司马沙尼,SU5416
Target: VEGFR
SU4312
Cat.No: T3570
Synonym: SU 4312,NSC 86429
Target: VEGFR, PDGFR
Tivozanib
Cat.No: T2456
Synonym: 替沃扎尼,AV-951,KRN951
Target: VEGFR, PDGFR, Ephrin Receptor
Pazopanib
Cat.No: T0097L
Synonym: 帕唑帕尼,GW786034
Target: VEGFR, FGFR, PDGFR, c-Kit, Autophagy
Cediranib
Cat.No: T2500
Synonym: AZD2171,NSC-732208,西地尼布
Target: VEGFR, FLT, PDGFR, c-Kit, Autophagy
Cat. No. Product Name Target Signaling Pathways
T1205 Chloramphenicol

Chlornitromycin,Levomycetin,Chloromycetin,氯霉素

ribosome; HIF/HIF Prolyl-Hydroxylase; Antibacterial; Antibiotic Chromatin/Epigenetic; Metabolism; Microbiology/Virology
Chloramphenicol (Chloromycetin) 是一种广谱抗生素,有效抑制细菌蛋白质生物合成。它主要作用于细菌 70S 核糖体的 50S 亚基,对肽基转移酶有活性,抑制肽键的形成。
TN1143 1-O-Acetyl britannilactone

NF-κB; COX Immunology/Inflammation; Neuroscience; NF-κB
1-O-Acetyl britannilactone shows antifungal, and anti-cancer activities, it suppresses angiogenesis and lung cancer cell growth possibly via regulating the VEGFR-Src-FAK signaling.
T38250 L-Sepiapterin

L-Sepiapterin, also known as Sepiapterin, is a precursor compound crucial for the production of tetrahydrobiopterin (BH4), which serves as a coenzyme for endothelial nitric oxide synthase (eNOS). This compound demonstrates its efficacy by improving endothelial dysfunction in small mesenteric arteries from db/db mice and promoting angiogenesis. Moreover, L-Sepiapterin exerts inhibitory effects on cellular proliferation and migration in ovarian cancer cells through the down-regulation of p70S6K-de...

天然产物

Chloramphenicol
Cat.No: T1205
Synonym: Chlornitromycin,Levomycetin,Chloromycetin,氯霉素
Target: ribosome, HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic
1-O-Acetyl britannilactone
Cat.No: TN1143
Synonym:
Target: NF-κB, COX
L-Sepiapterin
Cat.No: T38250
Synonym:
Target:
Cat. No. Product Name Species Expression System
TMPY-00637 FLT1 Protein, Human, Recombinant (aa 1-328, His)

VEGFR-1,fms-related tyrosine kinase 1<...

Human HEK293
Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor and FLT1, is a single-pass type I membrane protein and secreted protein which belongs to theprotein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 / FLT1 contains sevenIg-like C2-type (immunoglobulin-like) domains and oneprotein kinase domain. VEGFR-1 / F...
TMPY-02361 VEGFR2/KDR Protein, Human, Recombinant (His)

VEGFR2,kinase insert domain receptor,VEGFR...

Human HEK293
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ...
TMPJ-00412 VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)

Vascular endothelial growth factor receptor 1,Vascu...

Human Human Cells
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 is widely expressed in human tissues including normal lung, placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cellsand peripheral blood monocytes. VEGFR-1 contains seven Ig-like C2-type domains and one protein kinas...
TMPK-00454 VEGFR2/KDR Protein, Human, Recombinant (His & Avi)

VEGFR-21,Ly73,KRD1,VEGFR...

Human HEK293
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. The tyrosine kinase receptor vascular endothelial growth factor receptor 2 (VEGFR2) is a key regulator of angiogenesis.
TMPK-00645 VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His)

KRD1,VEGFR2,FLK1,CD309,Ly73,V...

Rhesus macaque HEK293
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. The tyrosine kinase receptor vascular endothelial growth factor receptor 2 (VEGFR2) is a key regulator of angiogenesis.
TMPY-06780 FLT1 Protein, Human, Recombinant (His & Avi), Biotinylated

FLT,fms-related tyrosine kinase 1,VEGFR

Human HEK293
Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor and FLT1, is a single-pass type I membrane protein and secreted protein which belongs to theprotein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 / FLT1 contains sevenIg-like C2-type (immunoglobulin-like) domains and oneprotein kinase domain. VEGFR-1 / F...
TMPY-02108 FLT1 Protein, Human, Recombinant (aa 1-756, His)

FLT-1,VEGFR1,fms-related tyrosine...

Human HEK293
Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor and FLT1, is a single-pass type I membrane protein and secreted protein which belongs to theprotein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 / FLT1 contains sevenIg-like C2-type (immunoglobulin-like) domains and oneprotein kinase domain. VEGFR-1 / F...
TMPY-04940 VEGFR2/KDR Protein, Human, Recombinant (His), Biotinylated

Flk-1,kinase insert domain receptor,VEGFR,...

Human HEK293
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ...
TMPY-00119 FLT1 Protein, Human, Recombinant (hFc)

VEGFR1,VEGFR-1,fms-relat...

Human HEK293
Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor and FLT1, is a single-pass type I membrane protein and secreted protein which belongs to theprotein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 / FLT1 contains sevenIg-like C2-type (immunoglobulin-like) domains and oneprotein kinase domain. VEGFR-1 / F...
TMPY-06665 FLT1 Protein, Mouse, Recombinant (His & Avi), Biotinylated

VEGFR1,sFlt1,AI323757,VEGFR

Mouse HEK293
Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor and FLT1, is a single-pass type I membrane protein and secreted protein which belongs to theprotein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 / FLT1 contains sevenIg-like C2-type (immunoglobulin-like) domains and oneprotein kinase domain. VEGFR-1 / F...
TMPY-05733 FLT1 Protein, Mouse, Recombinant (His)

Flt-1,VEGFR1,VEGFR-1...

Mouse HEK293
Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor and FLT1, is a single-pass type I membrane protein and secreted protein which belongs to theprotein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 / FLT1 contains sevenIg-like C2-type (immunoglobulin-like) domains and oneprotein kinase domain. VEGFR-1 / F...
TMPY-04795 VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, His)

kinase insert domain receptor,VEGFR2,FLK1,...

Human HEK293
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ...
TMPY-04794 VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc)

VEGFR,kinase insert domain receptor,Flk-1,...

Human HEK293
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ...
TMPY-04796 VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, His)

FLK1,kinase insert domain receptor,CD309,VEGFR<...

Human HEK293
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ...
TMPY-04530 VEGFR2/KDR Protein, Human, Recombinant (His & GST)

Flk-1,VEGFR2,kinase insert domain receptor...

Human Baculovirus-Insect Cells
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ...
TMPY-01044 VEGFR2/KDR Protein, Human, Recombinant (hFc)

Flk-1,CD309,FLK1,VEGFR2,VEGFR...

Human HEK293
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ...
TMPY-05657 VEGFR2/KDR Protein, Human, Recombinant (hFc), Biotinylated

VEGFR2,Flk-1,kinase insert domain receptor...

Human HEK293
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ...
TMPY-04802 VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, hFc)

kinase insert domain receptor,CD309,VEGFR2,FLK1...

Human HEK293
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ...
TMPY-05610 VEGFR2/KDR Protein, Human, Recombinant (His & Avi), Biotinylated

Flk-1,VEGFR,kinase insert domain receptor,...

Human HEK293
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ...
TMPY-02736 VEGFR2/KDR Protein, Mouse, Recombinant (His)

sVEGFR-2,6130401C07,kinase insert...

Mouse HEK293
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ...
TMPY-04924 VEGFR2/KDR Protein, Mouse, Recombinant (His), Biotinylated

VEGFR-2,6130401C07,Ly73,Krd-1...

Mouse HEK293
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ...
TMPY-02858 VEGFR2/KDR Protein, Mouse, Recombinant (hFc)

VEGFR2,6130401C07,Krd-1,...

Mouse HEK293
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be the primary signal transducer for angiogenesis and the development of pathological conditions such as cancer and diabetic retinopathy. It has been shown that VEGFR2 is expressed mainly in the endothelial cells, and the expression is upregulated in the tumor vasculature. Thus the ...
TMPK-00451 VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi), Biotinylated

FLT,Flt-1,FRT,VEGFR1,VEGF R1<...

Human HEK293
VEGFR1 (vascular endothelial growth factor receptor 1), also called Flt-1 (Fms-like tyrosine kinase), is a 180 kDa type I transmembrane glycoprotein in the class III subfamily of receptor tyrosine kinases (RTKs).yrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May pla...
TMPK-00450 VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi)

FLT1,FRT,FLT,Flt-1,VEGF R1,VE...

Human HEK293
VEGFR1 (vascular endothelial growth factor receptor 1), also called Flt-1 (Fms-like tyrosine kinase), is a 180 kDa type I transmembrane glycoprotein in the class III subfamily of receptor tyrosine kinases (RTKs).yrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May pla...
TMPJ-00414 VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated

Protein-tyrosine kinase receptor flk-1,KDR,Kinase i...

Human Human Cells
Human Vascular endothelial growth factor receptor 2(KDR, VEGFR-2) is a member of the class III subfamily of receptor tyrosine kinases (RTKs). KDR is involved in a number of fundamental biological processes such as the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. It also plays an essential role in promoting proliferation, survival, migration and differentiation of endothelial cells, reorganization of the actin cytoskeleton. VEGFR2 is identi...
TMPJ-00593 VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His)

KDR,Fetal liver kinase 1,VEGFR-2,Kinase in...

Human Human Cells
Human Vascular endothelial growth factor receptor 2(KDR, VEGFR-2) is a member of the class III subfamily of receptor tyrosine kinases (RTKs). KDR is involved in a number of fundamental biological processes such as the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. It also plays an essential role in promoting proliferation, survival, migration and differentiation of endothelial cells, reorganization of the actin cytoskeleton. VEGFR2 is identi...
TMPY-03299 FLT1 Protein, Rat, Recombinant (His)

fms-related tyrosine kinase 1

Rat HEK293
Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor and FLT1, is a single-pass type I membrane protein and secreted protein which belongs to theprotein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 / FLT1 contains sevenIg-like C2-type (immunoglobulin-like) domains and oneprotein kinase domain. VEGFR-1 / F...
TMPJ-00968 NAMPT Protein, Human, Recombinant (His)

PBEF,PBEF1,Nicotinamide phosphoribosyltransferase,N...

Human E. coli
Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, but it is also acknowledged to be the ubiquitous intracellular enzyme nicotinamide phosphoribosyltranferase (NAMPT) and the adipokine “visfatin”. PBEF is constitutively expressed in the fetal membranes where its greatest expression is in the amnion. It has intracellular and extracellular forms. Most of the intracellular functions of PBEF are ...
TMPY-04451 AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)

AMPK, AMPK(α1, β1, γ1)

Human Baculovirus-Insect Cells
AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus-Insect Cells
TMPY-03745 CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His)

CD3-DELTA,CD3d molecule, delta (CD3-TCR complex),CD3d molecu...

Human HEK293
CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in HEK293 with Flag and His tag. The predicted molecular weight is 31.05 kDa. Accession number: P04234-1&P07766-1
TMPY-00664 ANGPT2/Angiopoietin-2 Protein, Human, Recombinant (hFc)

Angiopoietin-2,AGPT2,angiopoietin 2,ANG2

Human HEK293
Angiopoietin-2 (ANG 2, or ANGPT2), is a member of the ANG family, which plays an important role in angiogenesis during the development and growth of human cancers. Both ANGPT-1 and ANGPT-2 appear to bind to the tyrosine kinase receptor, Tie-2, found primarily on the luminal surface of endothelial cells. ANG-2's role in angiogenesis generally is considered as an antagonist for ANG1, inhibiting ANG1-promoted Tie2 signaling, which is critical for blood vessel maturation and stabilization. ANG-2 mod...
TMPY-01298 CADM1 Protein, Human, Recombinant (His)

Necl-2,cell adhesion molecule 1,SYNCAM,BL2,sTSLC-

Human HEK293
Members of the immunoglobulin superfamily often play key roles in intercellular adhesion. IGSF4 is a novel immunoglobulin (Ig)-like intercellular adhesion molecule. Three Ig-like domains are included in the extracellular domain of IGSF4 and mediate homophilic or heterophilic interactions independently of Ca2+. The cytoplasmic domain of IGSF4 contains the binding motifs that connect to actin fibers. Since IGSF4 has been characterized by several independent research groups, this molecule is called...
TMPY-04779 BTN3A2 Protein, Human, Recombinant (His)

BTF3,BT3.2,BTF4,BTN3.2,CD277,butyrophilin subfamily 3 member...

Human HEK293
The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the function of T cells. BTN3A2 is overexpressed in gastric tumors, and deletion of BTN3A2 inhibited proliferation, migration, and invasion of gastric cancer cells. The butyrophilin 3 (BTN3) receptors are implicated in the T lymphocytes regulation and present a wide plasticity in mammals. A thorough phylogenetic analysis reveals a concerted...
TMPY-03363 C-Reactive Protein Protein, Human, Recombinant

C-Reactive Protein,C-reactive protein, pentraxin-related,PTX...

Human HEK293
C-reactive protein (CRP) is synthesized by the liver in response to factors released by fat cells. It is a member of the pentraxin family of proteins. The levels of CRP rise in response to inflammation. Human C-reactive protein (CRP) is the classical acute phase reactant, the circulating concentration of which rises rapidly and extensively in a cytokine-mediated response to tissue injury, infection and inflammation. Serum CRP values are routinely measured, empirically, to detect and monit...
TMPY-02512 Alpha-Synuclein Protein, Human, Recombinant

PD1,α-Synuclein,PARK4,synuclein, α (non A4 componen...

Human E. coli
Alpha-Synuclein (alpha-Syn), also known as NACP or SNCA, exists as at least two structural isoforms: one is helix-rich, membrane-bound form that both the N- and C-terminal regions of alpha-synuclein are tightly associated with membranes and the other is disordered, cytosolic form. Synuclein is found predominantly in the presynaptic termini, in both free or membrane-bound forms. SNCA is extensively localized in nucleus of neurons. It has been shown that alpha-Synuclein was highly expressed in the...
TMPY-05354 CD28 Protein, Human, Recombinant (hFc & Avi), Biotinylated

CD28 molecule,Tp44

Human HEK293
CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. Mouse CD28 is constitutively expressed on the surface of all murine T cells and on developing thymocytes as disulfide-linked homodimers or as monomers. CD28 can binds the B7-1 and B7-2 ligand, and together perform important functions in the T and B cell r...
TMPY-00586 CLEC-2 Protein, Mouse, Recombinant (hFc)

1810061I13Rik,Clec2,C-ty...

Mouse HEK293
CLEC1B, also known as CLEC2, is a C-type lectin-like receptor expressed in myeloid cells and NK cells. Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 and NKG2D, that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and...
TMPY-04824 CTLA-4 Protein, Human, Recombinant

CTLA-4,GSE,IDDM12,CELIAC3,ALPS5,CD,GRD4,cytotoxic T...

Human HEK293
Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role i...
TMPY-00986 IL-34 Protein, Mouse, Recombinant (His)

interleukin 34,2010004A03Rik,AI593503

Mouse HEK293
IL34 (Interleukin 34) is a Protein Coding gene. IL-34, also known as uncharacterized protein C16 or f77 homolog, belongs to the IL-34 family. IL-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R). IL-34 protein is expressed in various tissues, including heart, brain, lung, liver, kidney, spleen, thymus, testes, ovary, small intestine, prostate, and colon, and most abundant in the spleen. The colon...
TMPY-03273 IL-18 Protein, Mouse, Recombinant

interleukin 18,白细胞介素,白介素,Il-18,Igif

Mouse E. coli
Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of IL-18 and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its bi...
TMPY-02412 ENO1 Protein, Human, Recombinant (His)

PPH,NNE,enolase 1, (alpha),ENO1L1...

Human E. coli
The ENO1 gene encodes a multifunctional enzyme that has been identified as a key component of the glycolytic pathway. ENO1 overexpression and post-translational modifications could be of diagnostic and prognostic value in many cancer types. The results of the ENO1 expression profiling of ovarian follicles suggest that ENO1 may play an important dual role in the progress of follicular development, where ENO1 acts as a glycolytic enzyme and also mediates apoptosis. ENO1 overexpression could make ...
TMPY-01055 IL-4R Protein, Human, Recombinant (His)

interleukin 4 receptor,IL4RA,IL4R,CD124,IL-4RA

Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alters the behavior of the cell. Some CD proteins ...
TMPY-01912 Cadherin 17/CDH17 Protein, Human, Recombinant (His)

HPT-1,cadherin 17, LI cadherin (liver-inte...

Human HEK293
Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of ...
TMPY-01834 CD16/FCGR3 Protein, Mouse, Recombinant (aa 32-215, His)

CD16,Fc receptor, IgG, low affinity III

Mouse HEK293
Fc receptors bind the most common class of antibody, IgG, are called Fc gamma receptors (FcγR). FcγR is divided into three classes, Fc γ RI (CD64), Fc γ RII (CD32), and Fc γ RIII (CD16). CD16 protein is a multifunctional, low/intermediate affinity receptor, which belongs to the immunoglobulin superfamily. It is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. Mouse CD16 is encoded by a single gene, while, human CD16 is expressed as...
TMPY-01608 Decorin Protein, Human, Recombinant (His)

PGS2,PG40,CSCD,decorin,SLRR1B,DSPG2,PGII

Human HEK293
Decorin is a ubiquitous small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a core protein and a covalently linked glycosaminoglycan chain which is either chondroitin sulfate (CS) or dermatan sulfate (DS). As a component of connective tissue, decorin interacts with several extracellular matrix components, such as type I collagen and fibronectin, and plays a role...
TMPY-00843 IL-25/IL17E Protein, Human, Recombinant (hFc)

interleukin 25,IL17E

Human HEK293
Interleukin-25 (IL-25) is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. IL-25 is a member of the IL-17 family of cytokines. However, unlike the other members of this family, IL-25 promotes T helper (Th) 2 responses. IL-25 also regulates the development of autoimmune inflammation mediated by IL-17–produ...
TMPY-05277 IL-4R Protein, Human, Recombinant (hFc)

IL4R,IL4RA,CD124,IL-4RA,interleukin 4 receptor

Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alters the behavior of the cell. Some CD proteins ...
TMPY-04810 CD47 Protein, Mouse, Recombinant (His)

AA407862,CD47 molecule,AW108519,91

Mouse HEK293
CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the b...
TMPY-01280 FOLR2 Protein, Human, Recombinant (His)

FBP,β-HFR,FR-P3,BETA-HFR,folate receptor 2 (fetal),FR-BETA,F...

Human HEK293
Folate receptor beta, also known as Folate receptor 2, FBP, and FOLR2, is a member of the folate receptor family. FOLR2 is expressed in placenta and hematopoietic cells. The expression of FOLR2 is increased in malignant tissues. Members of the Folate receptor family members (FOLRs) have a high affinity for folic acid and for several reduced folic acid derivatives. They mediate the delivery of 5-methyltetrahydrofolate to the interior of, out of within, or between cells in a process known as potoc...
TMPY-01462 IL-11R alpha/IL-11RA Protein, Human, Recombinant (His)

interleukin 11 receptor subunit alpha,hCG_...

Human HEK293
Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in some cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. It is also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increas...
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重组蛋白

FLT1 Protein, Human, Recombinant (aa 1-328, His)
Cat.No: TMPY-00637
Species: Human
Expression System: HEK293
VEGFR2/KDR Protein, Human, Recombinant (His)
Cat.No: TMPY-02361
Species: Human
Expression System: HEK293
VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)
Cat.No: TMPJ-00412
Species: Human
Expression System: Human Cells
VEGFR2/KDR Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00454
Species: Human
Expression System: HEK293
VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His)
Cat.No: TMPK-00645
Species: Rhesus macaque
Expression System: HEK293
FLT1 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-06780
Species: Human
Expression System: HEK293
FLT1 Protein, Human, Recombinant (aa 1-756, His)
Cat.No: TMPY-02108
Species: Human
Expression System: HEK293
VEGFR2/KDR Protein, Human, Recombinant (His), Biotinylated
Cat.No: TMPY-04940
Species: Human
Expression System: HEK293
FLT1 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00119
Species: Human
Expression System: HEK293
FLT1 Protein, Mouse, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-06665
Species: Mouse
Expression System: HEK293
FLT1 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-05733
Species: Mouse
Expression System: HEK293
VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, His)
Cat.No: TMPY-04795
Species: Human
Expression System: HEK293
VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc)
Cat.No: TMPY-04794
Species: Human
Expression System: HEK293
VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, His)
Cat.No: TMPY-04796
Species: Human
Expression System: HEK293
VEGFR2/KDR Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-04530
Species: Human
Expression System: Baculovirus-Insect Cells
VEGFR2/KDR Protein, Human, Recombinant (hFc)
Cat.No: TMPY-01044
Species: Human
Expression System: HEK293
VEGFR2/KDR Protein, Human, Recombinant (hFc), Biotinylated
Cat.No: TMPY-05657
Species: Human
Expression System: HEK293
VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, hFc)
Cat.No: TMPY-04802
Species: Human
Expression System: HEK293
VEGFR2/KDR Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-05610
Species: Human
Expression System: HEK293
VEGFR2/KDR Protein, Mouse, Recombinant (His)
Cat.No: TMPY-02736
Species: Mouse
Expression System: HEK293
VEGFR2/KDR Protein, Mouse, Recombinant (His), Biotinylated
Cat.No: TMPY-04924
Species: Mouse
Expression System: HEK293
VEGFR2/KDR Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-02858
Species: Mouse
Expression System: HEK293
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00451
Species: Human
Expression System: HEK293
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00450
Species: Human
Expression System: HEK293
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated
Cat.No: TMPJ-00414
Species: Human
Expression System: Human Cells
VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His)
Cat.No: TMPJ-00593
Species: Human
Expression System: Human Cells
FLT1 Protein, Rat, Recombinant (His)
Cat.No: TMPY-03299
Species: Rat
Expression System: HEK293
NAMPT Protein, Human, Recombinant (His)
Cat.No: TMPJ-00968
Species: Human
Expression System: E. coli
AMPK (G1/B1/A1) Heterotrimer Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-04451
Species: Human
Expression System: Baculovirus-Insect Cells
CD3D & CD3E Heterodimer Protein, Human, Recombinant (Flag & His)
Cat.No: TMPY-03745
Species: Human
Expression System: HEK293
ANGPT2/Angiopoietin-2 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00664
Species: Human
Expression System: HEK293
CADM1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01298
Species: Human
Expression System: HEK293
BTN3A2 Protein, Human, Recombinant (His)
Cat.No: TMPY-04779
Species: Human
Expression System: HEK293
C-Reactive Protein Protein, Human, Recombinant
Cat.No: TMPY-03363
Species: Human
Expression System: HEK293
Alpha-Synuclein Protein, Human, Recombinant
Cat.No: TMPY-02512
Species: Human
Expression System: E. coli
CD28 Protein, Human, Recombinant (hFc & Avi), Biotinylated
Cat.No: TMPY-05354
Species: Human
Expression System: HEK293
CLEC-2 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-00586
Species: Mouse
Expression System: HEK293
CTLA-4 Protein, Human, Recombinant
Cat.No: TMPY-04824
Species: Human
Expression System: HEK293
IL-34 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-00986
Species: Mouse
Expression System: HEK293
IL-18 Protein, Mouse, Recombinant
Cat.No: TMPY-03273
Species: Mouse
Expression System: E. coli
ENO1 Protein, Human, Recombinant (His)
Cat.No: TMPY-02412
Species: Human
Expression System: E. coli
IL-4R Protein, Human, Recombinant (His)
Cat.No: TMPY-01055
Species: Human
Expression System: HEK293
Cadherin 17/CDH17 Protein, Human, Recombinant (His)
Cat.No: TMPY-01912
Species: Human
Expression System: HEK293
CD16/FCGR3 Protein, Mouse, Recombinant (aa 32-215, His)
Cat.No: TMPY-01834
Species: Mouse
Expression System: HEK293
Decorin Protein, Human, Recombinant (His)
Cat.No: TMPY-01608
Species: Human
Expression System: HEK293
IL-25/IL17E Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00843
Species: Human
Expression System: HEK293
IL-4R Protein, Human, Recombinant (hFc)
Cat.No: TMPY-05277
Species: Human
Expression System: HEK293
CD47 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-04810
Species: Mouse
Expression System: HEK293
FOLR2 Protein, Human, Recombinant (His)
Cat.No: TMPY-01280
Species: Human
Expression System: HEK293
IL-11R alpha/IL-11RA Protein, Human, Recombinant (His)
Cat.No: TMPY-01462
Species: Human
Expression System: HEK293
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