78
22
310
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21512 |
MMP-2/MMP-9 Inhibitor I
|
MMP | Proteases/Proteasome |
MMP-2/MMP-9-IN-1 是一种有效的、具有高选择性和可口服的 IV 型胶原酶 (MMP-9和MMP-2) 抑制剂,对 MMP-9 和 MMP-2具有抑制作用, IC50分别为 0.24 和 0.3 1μM。MMP-2/MMP-9-IN-1 在肿瘤生长和转移的动物模型中展现出口服活性,可用于研究癌症。 | |||
T36712 |
BPHA
MMP-2/MMP-9 Inhibitor II |
MMP | Proteases/Proteasome |
BPHA (MMP-2/MMP-9 Inhibitor II) 是一种有效的、具有选择性和口服活性的抑制剂,对MMP-2、MMP-9 和 MMP-14 具有抑制作用,IC50 分别为 12 nM、16 nM 和 17 nM。BPHA 不抑制 MMP-1、-3 和 -7 (IC50 分别为 974、>1000 和 795 nM)。BPHA 具有抗血管生成和抗肿瘤活性。 | |||
T14322 |
ARP-100
MMP-2 Inhibitor III |
MMP | Proteases/Proteasome |
ARP-100 (MMP-2 Inhibitor III) 是选择性基质金属蛋白酶MMP-2抑制剂 (IC50=12 nM)。它对 MMP-1 (>50 μM),MMP-3 (4.5 μM),MMP-7 (>50 μM) 和MMP-9 (0.2 μM) 的抑制活性较小。它与 MMP-2 的 S1'口袋相互作用,并在体外对基质胶的侵袭模型中显示抗侵袭特性。 | |||
T2009 |
SB-3CT
|
MMP | Proteases/Proteasome |
SB-3CT 是一种可透过血脑屏障的、竞争性的金属蛋白酶MMP-2和MMP-9抑制剂,Ki 分别为 13.9 nM、600 nM。他对明胶酶具有高选择性。它具有神经保护和抗癌作用。 | |||
T78181 |
MMP-7-IN-2
|
MMP; Others | Others; Proteases/Proteasome |
MMP-7-IN-2 可作为一种具有选择性和有效性的 MMP7 抑制剂,可用于研究炎症反应和与血管相关的疾病。 | |||
T4282 |
S-methyl-KE-298
|
MMP; Drug Metabolite | Metabolism; Proteases/Proteasome |
S-methyl-KE-298 是 KE-298 的活性代谢物。KE-298 抑制类风湿关节炎滑膜细胞产生基质金属蛋白酶。 | |||
T41079 |
MMP13-IN-2
MMP13-IN-2 |
||
MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases. | |||
T62555 |
MMP-2/9-IN-1
|
||
MMP-2/9-IN-1 (Compound 4a) 是一种有效的 MMP-2 (IC50: 56 nM) 和 MMP-9 (IC50: 38 nM) 双重抑制剂。MMP-2/9-IN-1 对肿瘤生长具有抑制作用,明显诱导癌细胞凋亡 (apoptosis),抑制细胞迁移,并抑制细胞周期进程导致 DNA 片段化。 | |||
T72719 | Tubulin/MMP-IN-2 | ||
Tubulin/MMP-IN-2是一种针对微管蛋白和基质金属蛋白酶的双重抑制剂,能有效抑制微管蛋白聚合并触发细胞凋亡。该化合物对MMP-2、MMP-3及MMP-9展现出明显的抑制效果,其IC50值分别为24.95 μM、31.60 μM与22.37 μM。Tubulin/MMP-IN-2主要应用于癌症研究领域。 | |||
T20563 |
PD-166793
PD-166793-0000,PD 166793,PD166793 |
MMP | Proteases/Proteasome |
PD-166793是一种具有口服活性、有效性和选择性的 MMP 抑制剂,对 MMP-2,MMP-3 和 MMP-13 具有抑制作用。PD-166793 在大鼠心力衰竭模型中改善心肌缺血和再灌注损伤。 | |||
T16966 |
S 3304
|
MMP | Proteases/Proteasome |
S 3304 是一种新型的基质金属蛋白酶抑制剂,能够特异的抑制MMP-2和MMP-9的活性。 | |||
TP1741L |
Histatin 5 acetate
Histatin 5 acetate (115966-68-2 Free base) |
MMP | Proteases/Proteasome |
Histatin 5 acetate 抑制宿主基质金属蛋白酶 MMP-2 和 MMP-9 的活性,IC50 分别为 0.57 和 0.25 μM。 | |||
T6885 |
Marimastat
BB2516,马立马司他,KB-R8898,TA2516 |
MMP | Proteases/Proteasome |
Marimastat (BB2516) 是一种血管生成和转移抑制剂,限制血管的生长和生成。它是一种广谱的,具有口服活性的MMPs 抑制剂,有效抑制 MMP-9 , MMP-1, MMP-2, MMP-14, MMP-7,用于癌症的研究。 | |||
T61271 |
MMP2-IN-3
|
MMP | Proteases/Proteasome |
MMP2-IN-3是一种有效的基质金属蛋白酶(MMP-2)抑制剂( IC50 值:31 μM)。MMP2-IN-3 抑制 MMP-9 和 MMP-8 ,其 IC50 分别为 26.6 和 32 μM。 | |||
T1891 |
NSC 405020
|
MMP | Proteases/Proteasome |
NSC 405020 是一种 MT1-MMP 的非催化抑制剂,可特异地靶向 MT1-MMP 的 PEX 结构域,不会抑制 MT1-MMP 和 MMP-2的催化活性。 | |||
T2743 |
Ilomastat
Galardin,GM6001,伊洛马司他 |
MMP | Proteases/Proteasome |
Ilomastat (GM6001) 是广谱的基质金属蛋白酶 (MMP) 抑制剂,可抑制 MMP 的活性,IC50值分别为 1.5 nM (MMP-1),1.1 nM (MMP-2),1.9 nM (MMP-3),0.5 nM (MMP-9),对人皮肤成纤维细胞胶原酶 (MMP-1) 的Ki=为 0.4 nM。 | |||
T6011 |
Batimastat
巴马司他,BB94 |
MMP | Proteases/Proteasome |
Batimastat (BB94) 是广谱MMP 抑制剂,能够抑制MMP-1 (IC50:3 nM),MMP-2 (IC50:4 nM),MMP-9 (IC50:4 nM),MMP-7 (IC50:6 nM) 和 MMP-3 (IC50:20 nM)。 | |||
TP1501L |
CTTHWGFTLC, CYCLIC acetate(244082-19-7 free base)
|
MMP | Proteases/Proteasome |
CTTHWGFTLC, CYCLIC acetate(244082-19-7 free base) 是基质金属蛋白酶 (MMP)-2 和 MMP-9 的抑制剂。它也被称为IV 型胶原酶或明胶酶。明胶酶是癌症治疗干预的潜在靶点,这些酶的抑制剂可以防止肿瘤进展。 | |||
T14091 |
AC-73
|
Autophagy | Autophagy |
AC-73 是一种可口服的 Cluster of Differentiation 147 (CD147) 抑制剂,具有很高的生物利用,可选择性破坏 CD147 的二聚化 (结合位点在 CD147 的 N 端 IgC2 域中包括 Glu64 和 Glu73),从而对 CD147/ERK1/2/STAT3/MMP-2 途径产生抑制,并抑制肝癌细胞的运动和侵袭。AC-73 具有抗增殖活性,诱导白血病细胞自噬。 | |||
T72069 |
MMP-9-IN-7
|
||
MMP-9-IN-7抑制前基质金属蛋白酶活化,可用于预防、治疗或改善 MMP9和/或 MMP13介导的综合征。 | |||
T36962 |
MMP Inhibitor I (trifluoroacetate salt)
|
||
MMP inhibitor I is a peptide inhibitor of matrix metalloproteinase-1 (MMP-1), MMP-2, and MMP-3 (IC50s = 1.3, 30, and 150 μM, respectively). It is selective for MMP-1, MMP-2, and MMP-3 over the proteases thermolysin, urease, trypsin, α-chymotrypsin, plasmin, and elastase at concentrations up to 4 mM. | |||
T10461 |
Batimastat sodium salt
BB-94 sodium salt |
MMP | Proteases/Proteasome |
Batimastat (BB-94) sodium salt is a broad-spectrum MMP inhibitor (IC50s: 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7, and MMP-3). | |||
T37983 |
GM 1489
|
||
GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. It reduces 5-aza-2'-deoxycytidine-induced increases in MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, and MMP-14 expression as well as cell invasion in AsPC-1, BxPC-3, Hs766T, MiaPaCa2, and PANC-1 cancer cells. Topical administration of GM 1489 (100 μg) inhibits increases in ear thickness and epidermal hyperplasia induced by phor... | |||
T28147 |
ND-378
|
||
ND-378 is a potent and selective inhibitor of MMP-2 with no inhibition on MMP-9 and MMP-14. | |||
T13358 |
XL-784
|
MMP | Proteases/Proteasome |
XL-784 is a selective inhibitor of matrix metalloproteinases (MMP)(IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respectively). | |||
T78775 |
MMP13-IN-5
|
MMP | Proteases/Proteasome |
MMP13-IN-5 (compound 13m) 作为具有针对性的MMP-2/MMP-13 抑制剂,显示出高效的抑制活性(IC50=3.6 μM/14.6 μM),适用于骨关节炎疼痛的研究。 | |||
T76618 |
VPLSLYSG
|
||
VPLSLYSG 是一种可被基质金属蛋白酶-9 (MMP-9)、MMP-1和MMP-2降解的八肽。VPLSLYSG 在MMP 底物中有潜在应用。 | |||
T22685 |
CP-471474
CP 471474 |
Others | Others |
Broad spectrum MMP inhibitor (IC<sub>50</sub> values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Attenuates early left ventricular dilation after experimental myocardial infarction in mice. | |||
T60083 |
MMP-12 Inhibitor
MMP12,MMP408 |
MMP | Proteases/Proteasome |
MMP-12 Inhibitor 是一种选择性的 MMP-12 抑制剂,对人、小鼠、大鼠和绵羊 MMP-12 的 IC50 分别为 2、160、320 和 22.3 nM。 | |||
T70051 |
MMI-166
|
||
MMI-166 is a selective matrix metalloproteinase (MMP) inhibitor that prevents tumor invasion and metastasis by downregulating the activity of MMP-2 and MMP-9. | |||
T16986 |
Tanomastat
BAY 12-9566 |
MMP | Proteases/Proteasome |
Tanomastat is an orally bioavailable and non-peptidic biphenyl matrix metalloproteinases inhibitor. For MMP-2, MMP-3, MMP-9, MMP-13 the Ki values are 11, 143, 301, and 1470 nM respectively. | |||
T36362 |
Dnp-PLGMWSR (trifluoroacetate salt)
|
||
Dnp-PLGMWSR is a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) and MMP-9. The activity of MMP-2 and MMP-9 can be quantified by measuring tryptophan fluorescence that is unquenched upon peptide hydrolysis that removes the N-terminal dinitrophenol (Dnp) group. | |||
T60551 | MMP2-IN-2 | ||
MMP2-IN-2 (化合物 42) 是一种有效且选择性的MMP-2(基质金属蛋白酶)抑制剂,其IC50值为 4.2 μM。它 对MMP-13、MMP-9和MMP-8也具有抑制活性,IC50值分别为 12、23.3 和 25 μM。 | |||
T13357 |
XL-784 free base
|
Others | Others |
XL-784 free base is a selective inhibitor of matrix metalloproteinases (MMP), (IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respectively). | |||
T24775 |
SD-2590 HCl
SD2590 HCl,SD-2590 Hydrochloride,SD2590 Hydrochloride,SD 2590 Hydrochloride |
||
SD-2590 HCl is an MMP-2,-3, -9, -8, 13, and -14 inhibitor. | |||
TP1446 |
Histatin 5 (TFA)(115966-68-2,free)
Histatin 5 (TFA) |
MMP | Proteases/Proteasome |
Histatin 5 (TFA)(115966-68-2,free) (Histatin 5 (TFA)) 抑制宿主基质金属蛋白酶 MMP-2 和 MMP-9 的活性,IC50 分别为 0.57 和 0.25 μM。 | |||
T76190 |
Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2
|
||
Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 是一种荧光底物,主要用于测定基质金属蛋白酶-1 (MMP-1)、MMP-3 和MMP-26的活性。 | |||
T75755 |
Histatin 5 TFA
|
||
Histatin 5 TFA 抑制宿主基质金属蛋白酶MMP-2和MMP-9活性,IC50s 分别为 0.57 和 0.25 μM。 | |||
T10597 |
BR351
|
MMP | Proteases/Proteasome |
BR351 is a brain penetrant MMP inhibitor (IC50s: 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13). | |||
T28146 |
ND-336
ND336,ND-336 hydrochloride,ND 336 |
||
ND-336 is a highly selective inhibitor ofMMP-2, MMP-9 and MMP-14. ND-336 accelerates diabetic wound healing by lowering inflammation and by enhancing angiogenesis and re-epithelialization of the wound. | |||
T12539L |
Prinomastat
KB-R9896,普啉司他,AG3340 |
MMP | Proteases/Proteasome |
Prinomastat inhibits MMP-2, MMP-3 and MMP-9 (Kis: 0.05 nM, 0.3 nM and 0.26 nM, respectively). Prinomastat crosses the blood-brain barrier. It also has antitumor activity. Prinomastat is a broad-spectrum, potent, orally active metalloproteinase inhibitor ( | |||
T76017 |
CTTHWGFTLC, CYCLIC TFA
|
||
CTTHWGFTLC, CYCLIC TFA 是一种基质金属蛋白酶 MMP-2和MMP-9的环肽抑制剂。对MMP-9的IC50约为 8 μM。 | |||
T61491 |
(R)-ND-336
|
||
(R)-ND-336 is a highly potent and selective MMP-9 inhibitor, displaying a K i value of 19 nM. It also exhibits inhibitory activity against MMP-2 (K i = 127 nM) and MMP-14 (K i =119 nM). With its significant potential, (R)-ND-336 is being investigated in the field of diabetic foot ulcers (DFUs) research [1]. | |||
T27033 |
CKD-712
CKD 712,CKD712 |
||
CKD-712 is a nuclear factor NF-kappa B inhibitor. CKD-712 suppressed MMP-9, but not MMP-2 and other NF-κB-regulated proteins involved in cancer metastasis such as VEGF. CKD-712 induced cell cycle arrest at G2M phase by suppressing cyclin A, cyclin B and C | |||
TQ0129 |
TNF Protease Inhibitor 2
TAPI-2 |
MMP | Proteases/Proteasome |
TAPI-2 is a broad-spectrum inhibitor of MMP (IC50: 20 μM), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM). | |||
T38800 |
MMPI-1154
|
||
MMPI-1154 is a highly promising imidazole-carboxylic acid (ICA) MMP-2 inhibitor (IC 50 = 6.6 μM) with excellent cardio-cytoprotective properties. It is specifically designed for the study of acute myocardial infarction. Additionally, MMPI-1154 exhibits significant inhibitory effects on MMP-13, MMP-1, and MMP-9 activities with IC 50 values of 1.8 μM, 10 μM, and 13 μM, respectively. | |||
TP1741 |
Histatin 5
|
||
Histatin 5 inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively. Histatin 5 is a human basic salivary peptide with strong fungicidal properties in vitro. | |||
T37726 |
MMP-9 Inhibitor I
|
||
MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). It also decreases the activity of TNF-α converting enzyme (TACE) in a dose-dependent manner (IC50 = 0.54 μM). MMP-9 inhibitor I decreases TNF-α secretion stimulated by LPS in BV-2 microglial cells when used at concentrations of 50 and 100 μM. | |||
T76269 |
Dnp-PLGLWA-DArg-NH2 TFA
|
||
Dnp-PLGLWA-DArg-NH2 TFA 作为MMP-1和MMP-9的荧光底物,能够用于定量测定MMPs的活性(Ex=280 nm, Em=360 nm)。 | |||
T62090 |
(Rac)-Tanomastat
|
||
Rac)-Tanomastat ((Rac)-BAY 12-9566) 是 Tanomastat 的外消旋体。其中 Tanomastat (BAY 12-9566) 是一种口服具有活力的、含锌羧基的非肽联苯基质金属蛋白酶(MMPs)抑制剂,能够抑制 MMP-2 (Ki: 11 nM)、MMP-3 (Ki: 143 nM)、MMP-9 (Ki: 301 nM)、MMP-13 (Ki: 1470 nM)。在几种实验性肿瘤模型中,Tanomastat 表现出抗侵袭和抗转移作用。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5S0045 |
Isofraxidin
6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶 |
MMP; ERK; p38 MAPK; TLR; COX | Immunology/Inflammation; MAPK; Neuroscience; Proteases/Proteasome |
Isofraxidin (Phytodolor) 是来自刺五加的香豆素成分,抑制MMP-7表达和人肝癌细胞侵袭。它作用于肝癌细胞,抑制ERK1/2磷酸化。它减弱iNOS 和COX-2表达,还抑制TLR4/髓样分化蛋白 2 复合物的形成。 | |||
T3813 |
20(R)-Ginsenoside Rh2
20(R)-人参皂苷 RH2,(20R)Ginsenoside Rh2,Ginsenoside Rh2,20(R)-人参皂苷Rh2 |
Apoptosis; MMP; HSV | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
20(R)-Ginsenoside Rh2 (Ginsenoside Rh2) 是人参皂苷 Rh2 的次要立体异构体,具有基质金属蛋白酶抑制作用。它有抗癌、抗炎和抗氧化活性。 | |||
T2769 |
3-Aminopropionitrile fumarate (2:1)
Di-β-aminopropionitrile fumarate,3-Aminopropionitrile fumarate,3-氨基丙腈,β-Aminopropionitrile fumarate,3-Aminopropionitrile fumarate 2:1,Beta-Aminopropionitrile fumarate,β-Ammoniumpropionitrile hemifumarate |
Others | Others |
3-Aminopropionitrile fumarate (2:1) (β-Aminopropionitrile fumarate) 是一种能抑制胶原蛋白(collagen)交联的山黧豆素。 | |||
T6S0325 |
Glycitein
黄豆黄素,Glycetein |
Apoptosis; Others | Apoptosis; Others |
Glycitein (Glycetein) 是一种大豆异黄酮,可研究抗氧化和细胞凋亡。 | |||
T7044 |
Norepinephrine
去甲肾上腺素,Levophed,Levonoradrenaline,Aktamin,Nor-Epirenan,Levonor,Arterenol |
MMP; Endogenous Metabolite; Adrenergic Receptor; Autophagy | Autophagy; GPCR/G Protein; Metabolism; Neuroscience; Proteases/Proteasome |
Norepinephrine (Levophed) 是β1选择性的肾上腺素能受体激动剂,EC50值为 5.37 μM。它可上调鼻咽癌肿瘤细胞中血管内皮生长因子、基质金属蛋白酶MMP-2和MMP-9的表达。 | |||
T3524 |
Halofuginone hydrobromide
卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐 |
Others; Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Others; Stem Cells |
Halofuginone hydrobromid 是Febrifugine 的衍生物,是竞争性脯氨酰-tRNA 合成酶抑制剂。它是 I 型胶原合成的特异性抑制剂,并通过抑制TGF-β活性可减轻骨关节炎。它具有抗疟疾、抗炎、抗癌、抗纤维化作用。 | |||
T3729 |
Ethyl gallate
Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯 |
MMP; NF-κB; Akt; Antibacterial | Cytoskeletal Signaling; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Ethyl gallate (gallic acid ethyl ester) 是一种非类黄酮酚过氧化氢清除剂。 | |||
T2973 |
Astragaloside IV
AST-IV,黄芪甲苷IV,AS-IV,黄芪皂苷 IV |
MMP; ERK; Estrogen/progestogen Receptor; JNK | Endocrinology/Hormones; MAPK; Proteases/Proteasome |
Astragaloside IV (AS-IV) 是从黄芪中分离得到的一种皂苷,抑制ERK1/2和JNK 激活,在乳腺癌细胞 MDA-MB-231 中,下调(MMP)-2和(MMP)-9的信号通路。 | |||
T5S1262 |
Methylophiopogonanone A
|
Others | Others |
Methylophiopogonanone A 是从Ophiopogon japonicas 提取到的黄酮类化合物,具有抗炎和抗氧化的特性。它通过调节 MMP-9 和紧密连接蛋白的表达来减轻 BBB 破坏的能力,具有治疗脑 I/R 损伤的潜力。 | |||
T5740 |
25(R,S)-Ruscogenin
(25RS)鲁斯可皂苷元,(25RS)-Ruscogenin |
Others; HIF | Angiogenesis; Chromatin/Epigenetic; Others |
25(R,S)-Ruscogenin 能够调节 PI3K/Akt/mTOR 信号通路,抑制 MMP-2、MMP-9、uPA、VEGF 和 HIF-1α 的表达,阻碍肝癌转移。 它能够抑制 TLR4信号通路,减轻 LPS 诱导的肺内皮细胞凋亡。 | |||
T4034 |
Solamargine
Solamargin,δ-Solanigrine,澳洲茄边碱 |
Apoptosis; p38 MAPK; P-gp; STAT | Apoptosis; JAK/STAT signaling; MAPK; Membrane transporter/Ion channel; Neuroscience; Stem Cells |
Solamargine (δ-Solanigrine) 是一种来源于茄属植物的类固醇 Solasodine 的衍生物,诱导非选择性细胞毒性和 P-gp 抑制作用。它通过下调 MMP-2 和 MMP-9 的表达和活性来显著抑制 HepG2 细胞的迁移和侵袭,在多种癌症中均表现出抗癌活性。 | |||
T3895 |
Polyphyllin I
重楼皂苷I,重楼皂甙 |
Apoptosis; Akt; JNK; PDK; mTOR; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling |
Polyphyllin I 是从七叶一枝花中提取的生物活性成分,具有很强的抗肿瘤活性。它是 JNK 信号通路的激活剂,也是 PDK1/Akt/mTOR 信号传导的抑制剂。它诱导自噬,G2/M 期阻滞和细胞凋亡。 | |||
T5S0053 |
Coptisine
黄连碱,Coptisin |
Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
Coptisine (Coptisin) 是一种从黄连中分离到的生物碱,是非竞争性的IDO 抑制剂,Ki=为 5.8 μM,IC50=6.3 μM。 | |||
T6S1699 |
Shogaol
[6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol |
Lipoxygenase; Autophagy | Autophagy; Metabolism |
6-Shogaol (6-Shogaol) 是从生姜中分离的一种天然产物,具有抗癌、抗炎和抗氧化的多种生物活性。 | |||
T3S1641 |
Esculentoside H
|
TNF; NF-κB; JNK | Apoptosis; MAPK; NF-κB |
Esculentoside H 是一种皂苷,分离自多年生植物 Phytolacca esculent 的根提取物中,具有抗肿瘤作用。它的机制与 TNF 释放能力有关。它能够阻断 JNK1/2和 NF-κB 信号介导的基质金属蛋白酶-9 (MMP-9) 表达,抑制结肠癌细胞迁移。 | |||
T6S2140 |
β-Anhydroicaritin
Anhydroicaritin,Beta-Anhydroicaritin,脱水淫羊藿素 |
MMP; Others; TNF; Interleukin | Apoptosis; Immunology/Inflammation; Others; Proteases/Proteasome |
β-Anhydroicaritin 是从乳香提取的一种天然产物,具有重要的生物学和药理学作用,如抗骨质疏松症,雌激素调节和抗肿瘤特性。它改善牙周组织的降解,抑制糖尿病大鼠 TNF-α 和 MMP-3 的合成和分泌。它抑制细胞内 Ca2+的升高,并显著降低 iNOS 蛋白的表达。 | |||
T72730 |
D-Isofloridoside
|
||
D-Isofloridoside 是多糖前体之一,具有清除自由基、抑制ROS 表达、抑制MMP-2和MMP-9的活性。 | |||
TN4978 |
Scutellarein-7-O-glucoside
|
MMP | Proteases/Proteasome |
Scutellarein-7-O-glucoside inhibites MMP-2 activity. | |||
T14121 |
Actinonin
(-)-Actinonin |
Aminopeptidase | Metabolism |
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM, it also is an apoptosis inducer. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase, it also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5]. | |||
TN1832 |
Kanzonol C
|
Others; NF-κB; Tyrosinase | NF-κB; Others; Proteases/Proteasome |
Kanzonol C has antimicrobial activity, it also shows potent PTP1B inhibitory activity (IC50 value of 0.31-0.97uM). Kanzonol C has chemopreventive activity,it shows the inhibition of matrix metalloproteinase (MMP)-2 secretion from brain tumor-derived glioblastoma cells. | |||
TN1881 |
Lucidenic acid C
赤芝酸 C,赤芝酸C |
MMP | Proteases/Proteasome |
Lucidenic acid C has anti-invasive effect, it shows significant inhibitory effects on PMA-induced MMP-9 activity and invasion of HepG(2 )cells. | |||
TN4046 |
Excisanin A
|
MMP; FAK; PARP; GSK-3; NF-κB; Wnt/beta-catenin; Akt; Caspase; PI3K; Prostaglandin Receptor; JNK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors |
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the ... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01477 |
MMP-2 Protein, Human, Recombinant
TBE-1,MMP-II,matrix metallopeptidase 2,MON... |
Human | HEK293 Cells |
MMP-2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 72 kDa and the accession number is A0A024R6R4. | |||
TMPY-01248 |
MMP-9 Protein, Human, Recombinant
MANDP2,MMP-9,GELB,matrix metallopeptidase ... |
Human | HEK293 Cells |
MMP-9 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 76.3 kDa and the accession number is P14780. | |||
TMPY-00888 |
MMP-9 Protein, Human, Recombinant (His)
MANDP2,CLG4B,GELB,matrix metallopeptidase 9,MMP... |
Human | HEK293 Cells |
MMP-9 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 77.7 kDa and the accession number is P14780. | |||
TMPY-02290 |
MMP-2 Protein, Mouse, Recombinant (His)
GelA,Clg4a,MMP-2,matrix metallopeptidase <... |
Mouse | HEK293 Cells |
MMP-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 30.9 kDa and the accession number is P33434-1. | |||
TMPJ-00362 |
MMP-2 Protein, Human, Recombinant (His)
72 kDa Gelatinase,TBE-1,Gelatinase A,Matrix Metallo... |
Human | HEK293 Cells |
72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene.It belongs to the matrix metalloproteinase (MMP) family. Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis and tissue remodeling, as well as pathologic... | |||
TMPK-00368 |
MMP-9 Protein, Human, Recombinant (His & Avi), Biotinylated
Gelatinase B,MMP-9,MANDP2,CLG4B,GELB |
Human | HEK293 Cells |
Matrix metalloproteinase 9 (MMP9) contributes to this process and deficiencies in the MMP9 lead to impaired healing. Inappropriate expression of MMP9 also contributes to impaired re-epithelialization. Previously we demonstrated that FOXO1 was activated in wound healing but to higher levels in diabetic wounds. To address mechanisms of impaired re-epithelialization we examined MMP9 expression in vivo in full thickness dermal scalp wounds created in experimental K14. MMP-9 Protein, Human, Recombina... | |||
TMPK-00503 |
MMP-9 Protein, Cynomolgus, Recombinant (His)
MMP-9,CLG4B,Gelatinase B,MANDP2,GELB |
Cynomolgus | HEK293 Cells |
Matrix metalloproteinase 9 (MMP9) contributes to this process and deficiencies in the MMP9 lead to impaired healing. Inappropriate expression of MMP9 also contributes to impaired re-epithelialization. Previously we demonstrated that FOXO1 was activated in wound healing but to higher levels in diabetic wounds. To address mechanisms of impaired re-epithelialization we examined MMP9 expression in vivo in full thickness dermal scalp wounds created in experimental K14. MMP-9 Protein, Cynomolgus, Reco... | |||
TMPK-00367 |
MMP-9 Protein, Human, Recombinant (His & Avi)
MANDP2,CLG4B,Gelatinase B,GELB,MMP-9 |
Human | HEK293 Cells |
Matrix metalloproteinase 9 (MMP9) contributes to this process and deficiencies in the MMP9 lead to impaired healing. Inappropriate expression of MMP9 also contributes to impaired re-epithelialization. Previously we demonstrated that FOXO1 was activated in wound healing but to higher levels in diabetic wounds. To address mechanisms of impaired re-epithelialization we examined MMP9 expression in vivo in full thickness dermal scalp wounds created in experimental K14. MMP-9 Protein, Human, Recombina... | |||
TMPK-01286 |
MMP-8 Protein, Cynomolgus, Recombinant (His)
Collagenase 2,HNC,CLG1,MMP8,PMNL-CL |
Cynomolgus | HEK293 Cells |
Alteration of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) expression has been studied for various cardiac diseases, including dilated cardiomyopathy (DCM), with the significance of surrogate markers of extracellular matrix (ECM) remodeling. MMP-8 was identified only in myocardiocytes, while MMP-9 and TIMP-2 were present in both myocardiocytes and stroma, but with different intensity. The increasing intensity of MMP-8 and TIMP-2 immunoreactions was signifi... | |||
TMPH-01665 |
TIMP3 Protein, Human, Recombinant (His)
|
Human | E. coli |
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. | |||
TMPJ-01289 |
TIMP-4 Protein, Human, Recombinant (His)
TIMP4,TIMP-4,Metalloproteinase inhibitor 4,Tissue inhibitor ... |
Human | HEK293 Cells |
Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene, belongs to the protease inhibitor I35 (TIMP) family. The protein complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9. | |||
TMPJ-00916 |
TIMP-2 Protein, Mouse, Recombinant (His)
metalloproteinase inhibitor 2,Tissue inhibitor of m... |
Mouse | HEK293 Cells |
Mouse Metalloproteinase inhibitor 2(TIMP-2), belongs to a family of proteins that regulate the activation and proteolytic activity of matrix metalloproteinases (MMPs). There are four mammalian members of the family; TIMP‑1, TIMP‑2, TIMP‑3, and TIMP‑4. The TIMP-2 is detected in testis, retina, hippocampus and cerebral cortex. The function of TIMP 2 protein is to inhibit MMPs non covalently by the formation of binary complexes. Complexes with metalloproteinases (such as collagenases) and irreversi... | |||
TMPJ-00082 |
NGAL/Lipocalin-2 Protein, Mouse, Recombinant (hFc)
Lipocalin-2,SV-40-induced 24P3 protein,Sid... |
Mouse | HEK293 Cells |
Lipocalin-2, also known as Neutrophil Gelatinase-Associated Lipocalin (NGAL), is a secretory protein of the lipocalin superfamily. Lipocalin-2 contains a signal peptide that enables it to be secreted and form complexes with matrix metalloproteinase-9 (MMP-9) through disulfide bonds. Similar to other lipocalin family members, Lipocalin-2 is involved in diverse cellular processes, including the transport of small hydrophobic molecules, protection of MMP-9 from proteolytic degradation, and cell sig... | |||
TMPY-00886 |
MMP-1 Protein, Human, Recombinant (His)
CLGN,CLG,matrix metallopeptidase 1 |
Human | HEK293 Cells |
MMP1, also known as MMP-1, contains 4 hemopexin-like domains and is a member of the matrix metalloproteinase (MMP) family. Matrix metalloproteases, also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and some bioactive molecules. MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMP... | |||
TMPJ-00948 |
Endostatin Protein, Mouse, Recombinant (His)
antiangiogenic agent,type XVIII,collagen α-1(XVIII)chain,col... |
Mouse | HEK293 Cells |
Endostatin, an endogenous non‑glycosylated inhibitor of endothelial cell proliferation and angiogenesis. It is produced and/or trimmed by metalloproteinases such as MMP‑2 and MMP‑9, and cathepsins S, B and L. The N‑terminal ~27 aa of Endostatin appear to contain the majority of its activity. This region contains zinc binding sites that are thought to be critical for its anti‑endothelial and anti‑tumor effects, as well as multiple cleavage sites that, when used, can modify its activity. Mouse End... | |||
TMPY-01900 |
Kallikrein 4/KLK4 Protein, Human, Recombinant (His)
PSTS,kallikrein,kallikrein-related peptidase 4,EMSP,EMSP1,AR... |
Human | HEK293 Cells |
Kallikrein-4, also known as Enamel matrix serine proteinase 1, Kallikrein-like protein 1, KLK-L1, Serine protease 17, KLK4, PRSS17, and EMSP1, is a secreted protein that belongs to the peptidase S1 family and Kallikrein subfamily. Kallikrein-4 / KLK4 is a serine protease expressed during enamel maturation, and proteolytic processing of the enamel matrix by KLK4 is critical for proper enamel formation. Kallikrein-4 / KLK4 contains one peptidase S1 domain. Kallikrein-4 / KLK4 is secreted by transi... | |||
TMPY-02404 |
ADAM9 Protein, Mouse, Recombinant (His)
mKIAA0021,AU020942,ADAM metallope... |
Mouse | HEK293 Cells |
ADAM9 (A disintegrin and metallopeptidase domain 9, MDC9, meltrin gamma), is a type 1 transmembrane protein that has been associated with cancer development and metastases. ADAM9 is consistently overexpressed in various human cancers, and plays a role in tumorigenesis in mouse models. ADAM9 cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as EGF, FGFR2iiib, Tie-2, Flk-1, EphB4, CD40, VCAM-1, and VE-cadherin, and could represent a potential t... | |||
TMPY-01442 |
DMBT1 Protein, Human, Recombinant (His)
GP340,deleted in malignant brain tumors 1,muclin |
Human | HEK293 Cells |
Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB domains, 14SRCR domains and 1ZP domain. It is highly expressed in alveolar and macrophage tissues. In some macrophages, expression is detected on the membrane, and in other macrophages, it is strongly expressed in the phagosome/phagolysosome compartments. Defects in DMBT1 are invo... | |||
TMPJ-00850 |
ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)
Protein T1,suppression of tumorigenicity 2,Ly84,DER... |
Mouse | HEK293 Cells |
ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 55-70 KDa and the accession number is P14719-2. | |||
TMPY-00891 |
Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)
neuropilin 1,VEGF165R,CD304,NP1,Neuropilin-1,NRP,BDCA4 |
Human | HEK293 Cells |
Neuropilin-1 Protein, Human, Recombinant (V179A, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.5 kDa and the accession number is O14786-2. | |||
TMPY-02011 |
CD96 Protein, Human, Recombinant (His)
CD96 molecule,TACTILE |
Human | HEK293 Cells |
CD96 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55 kDa and the accession number is P40200-2. | |||
TMPY-04113 |
KRAS Protein,Human,Recombinant(G12D & Q61H, His)
Kirsten rat sarcoma viral oncogene homolog,KRAS2,KI... |
Human | E. coli |
KRAS Protein,Human,Recombinant(G12D & Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.3 kDa and the accession number is P01116-2. | |||
TMPY-01613 |
Periostin/OSF-2 Protein, Mouse, Recombinant (His)
A630052E07Rik,OSF-2,Osf2,PLF,AI74... |
Mouse | HEK293 Cells |
Periostin/OSF-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 89 kDa and the accession number is Q62009-2. | |||
TMPY-01717 |
VEGF164 Protein, Mouse, Recombinant
vascular endothelial growth factor A,Vpf,Vegf,血管内皮生长因子 |
Mouse | Baculovirus Insect Cells |
VEGF164 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 19.4 kDa and the accession number is Q00731-2. | |||
TMPY-02096 |
TACI Protein, Human, Recombinant (His)
RYZN,IGAD2,CVID,TACI,TNFRSF14B,CVID2,tumor... |
Human | HEK293 Cells |
TACI Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is O14836-2. | |||
TMPY-00341 |
FGFR3 Protein, Human, Recombinant (alpha IIIb, His)
CEK2,HSFGFR3EX,fibroblast growth factor receptor 3,... |
Human | HEK293 Cells |
FGFR3 Protein, Human, Recombinant (alpha IIIb, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 40 kDa and the accession number is P22607-2. | |||
TMPY-06056 |
KRAS Protein, Human, Recombinant (G12D, His)
KRAS1,K-RAS4B,Kirsten rat sarcoma viral oncogene homolog,RAL... |
Human | E. coli |
KRAS Protein, Human, Recombinant (G12D, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22 kDa and the accession number is P01116-2. | |||
TMPY-00751 |
TrkB Protein, Human, Recombinant (His)
trk-B,GP145-TrkB/GP95-TrkB,neurotrophic tyrosine kinase, rec... |
Human | HEK293 Cells |
TrkB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is Q16620-2. | |||
TMPY-01691 |
Clusterin Protein, Human, Recombinant (CLU34, His)
SGP-2,AAG4,KUB1,CLI,CLU2,TRPM2,AP... |
Human | HEK293 Cells |
Clusterin Protein, Human, Recombinant (CLU34, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.5 kDa and the accession number is P10909-2. | |||
TMPY-04844 |
BTN3A1 Protein, Human, Recombinant (His)
BTN3.1,butyrophilin subfamily 3 member A1,BTF5,BT3.1,CD2... |
Human | HEK293 Cells |
BTN3A1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.6 kDa and the accession number is O00481-2. | |||
TMPY-05288 |
PLGF/PGF Protein, Human, Recombinant (aa 19-149)
PLGF,PGFL,placental growth factor,D12S1900,SHGC-107... |
Human | E. coli |
PLGF/PGF Protein, Human, Recombinant (aa 19-149) is expressed in E. coli expression system. The predicted molecular weight is 14.9 kDa and the accession number is P49763-2. | |||
TMPY-02820 |
SDF-1 Protein, Human, Recombinant (isoform a)
SDF1,chemokine (C-X-C motif) ligand 12,IRH,SCYB1 |
Human | E. coli |
SDF-1 Protein, Human, Recombinant (isoform a) is expressed in E. coli expression system. The predicted molecular weight is 8 kDa and the accession number is P48061-2. | |||
TMPY-01935 |
c-Kit Protein, Human, Recombinant (His)
PBT,CD117,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncog... |
Human | HEK293 Cells |
c-Kit Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.7 kDa and the accession number is P10721-2. | |||
TMPY-04356 |
GSK3B Protein, Human, Recombinant (His)
glycogen synthase kinase 3 beta,glycogen synthase kinase 3 β |
Human | Baculovirus Insect Cells |
GSK3B Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50.4 kDa and the accession number is P49841-2. | |||
TMPY-02500 |
YKL-40/CHI3L1 Protein, Mouse, Recombinant (His)
Gp39,AW208766,Brp39,chitinase 3 like 1 |
Mouse | HEK293 Cells |
YKL-40/CHI3L1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.3 kDa and the accession number is Q61362-2. | |||
TMPY-04396 |
C-ABL/ABL1 Protein, Human, Recombinant (GST)
v-abl,ABL,JTK7,ABL proto-oncogene 1, non-receptor tyrosine k... |
Human | Baculovirus Insect Cells |
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity an... | |||
TMPY-01985 |
CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated
FCGR2,FCGR21,CD32A,FCG2,... |
Human | HEK293 Cells |
CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 24 kDa and the accession number is P31994-2. | |||
TMPY-04644 |
PDGFB Protein, Human, Recombinant (His)
platelet-derived growth factor beta polypeptide,SSV,c-sis,SI... |
Human | P. pastoris (Yeast) |
Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted... | |||
TMPY-05414 |
NKG2D/CD314 Protein, Mouse, Recombinant (hFc)
D6H12S2489E,NKG2-D,killer cell le... |
Mouse | Baculovirus Insect Cells |
NKG2D/CD314 Protein, Mouse, Recombinant (hFc) is expressed in Baculovirus insect cells with hFc tag. The predicted molecular weight is 44.9 kDa and the accession number is O54709-2. | |||
TMPY-01871 |
IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His)
interleukin 5 receptor, alpha,IL5R,CD125,CDw12<... |
Human | HEK293 Cells |
IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.3 kDa and the accession number is Q01344-2. | |||
TMPY-02792 |
GDNF Protein, Human, Recombinant (HEK293)
HSCR3,ATF2,HFB1-GDNF,ATF1,glial cell derived neurot... |
Human | HEK293 Cells |
GDNF Protein, Human, Recombinant (HEK293) is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.1 kDa and the accession number is P39905-2. | |||
TMPY-01888 |
KRAS Protein,Human, Recombinant (Q61H, His)
KRAS2,C-K-RAS,Kirsten rat sarcoma viral oncogene ho... |
Human | E. coli |
KRAS Protein,Human, Recombinant (Q61H, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22.5 kDa and the accession number is P01116-2. | |||
TMPY-01359 |
ST2/IL-1 RL1 Protein, Human, Recombinant (His)
IL1RL1,IL‑1 R4,DER4,ST2,IL33R,interleukin 1 recepto... |
Human | HEK293 Cells |
ST2/IL-1 RL1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is Q01638-2. | |||
TMPY-00747 |
Nectin-2 Protein, Human, Recombinant (His)
PVRR2,Nectin-2,poliovirus receptor-related... |
Human | HEK293 Cells |
Nectin-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.2 kDa and the accession number is Q92692-2. | |||
TMPY-05427 |
CD19 Protein, Human, Recombinant (hFc)
CVID3,B4,CD19 molecule |
Human | HEK293 Cells |
CD19 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56.8 kDa and the accession number is P15391-2. | |||
TMPJ-00335 |
TGFBR2 Protein, Mouse, Recombinant (His)
TGFR-2,TGF-beta type II receptor,Transforming growt... |
Mouse | HEK293 Cells |
TGFBR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 25-38 KDa and the accession number is Q62312-2. | |||
TMPY-04051 |
c-Kit Protein, Human, Recombinant (hFc)
SCFR,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene h... |
Human | HEK293 Cells |
c-Kit Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82 kDa and the accession number is P10721-2. | |||
TMPY-00005 |
FGF-8a Protein, Human, Recombinant
fibroblast growth factor 8 (androgen-induced),FGF-8,AIGF,NEW... |
Human | E. coli |
In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling fac... | |||
TMPY-03425 |
Tau Protein, Human, Recombinant (His)
PPND,FTDP-17,MTBT1,DDPAC,MAPTL,MTBT2,microtubule-as... |
Human | E. coli |
MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP... | |||
TMPY-01199 |
CD74 Protein, Human, Recombinant (His)
II,DHLAG,Ia-GAMMA,CD74 molecule, major histocompatibility co... |
Human | HEK293 Cells |
CD74 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.4 kDa and the accession number is P04233-2. | |||
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