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Search Results for " dihydrochloride "

547

抑制剂 & 化合物

20

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T15374	Ipatasertib dihydrochloride GDC-0068 dihydrochloride,RG-7440 dihydrochloride	Akt; PKA	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) 是ATP 竞争性的pan-Akt 选择性抑制剂，抑制Akt1，Akt2，Akt3，IC50分别为 5，18，8 nM。
T7821	DG172 dihydrochloride DG172 (dihydrochloride),DG-172 dihydrochloride	PPAR	DNA Damage/DNA Repair; Metabolism
	DG172 dihydrochloride (DG-172 dihydrochloride) 是一种 PPARβ/δ拮抗剂，IC50值为 27 nM。
T11345L	Lerociclib dihydrochloride G1T38 dihydrochloride	CDK	Cell Cycle/Checkpoint
	Lerociclib dihydrochloride (G1T38 dihydrochloride) 是一种有效的选择性CDK4/CDK6抑制剂，抑制CDK6/CyclinD3和CDK4/CyclinD1，IC50值分别为 2 nM 和 1 nM。
T9172	Simufilam dihydrochloride PTI-125 dihydrochloride	Others	Others
	Simufilam dihydrochloride (PTI-125 dihydrochloride) 是口服具有活力的、毒性低的 filamin A 激活剂。它可优先结合改变的 FLNA，并恢复其天然构象，恢复受体和突触活性，并减少其与 a7nAChR/TLR4 的关联和下游病理作用。它可用于研究阿尔茨海默症。
T10358	Netarsudil Dihydrochloride AR-13324 Dihydrochloride	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) 是 Rho 相关蛋白激酶 (ROCK) 和去甲肾上腺素转运蛋白 (NET) 的抑制剂，可有效降低眼压 (IOP)。
T9012	Preq1-Dihydrochloride pre-queuosine1 Dihydrochloride	Others	Others
	Preq1-Dihydrochloride (pre-queuosine1 Dihydrochloride) 是 queuosine 途径的中间体，它以高亲和力结合 PreQ1 核糖开关的适体，从而减弱蛋白质表达。
T22354	Levocetirizine Dihydrochloride Xyzal Dihydrochloride,(-)-Cetirizine Dihydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor. Levocetirizine Dihydrochloride is the R-enantiomer of Cetirizine, which gives it a higher affinity for the H1-receptor than the S-enantiomer. Due to this enhanced affinity, Levocetirizine Dihydrochloride is effective in treating allergic rhinitis and chronic idiopathic urticaria.
T4467	UAMC00039 dihydrochloride UAMC 00039 dihydrochloride	Proteasome	Proteases/Proteasome; Ubiquitination
	UAMC00039 dihydrochloride 是可逆、竞争性的 dipeptidyl peptidase II 高效抑制剂，IC50=为0.48 nM。
T12374	PAβN dihydrochloride MC-207,110 dihydrochloride,Phe-Arg-β-naphthylamide dihydrochloride	Others; Antibacterial	Microbiology/Virology; Others
	PAβN dihydrochloride (MC-207,110 dihydrochloride) 是一种外排泵抑制剂。
T13675	Elacestrant dihydrochloride RAD1901 dihydrochloride	Estrogen/progestogen Receptor	Endocrinology/Hormones
	Elacestrant dihydrochloride (DA-DKRAD1901 dihydrochloride) 是一种具有口服活性的的选择性雌激素受体 (ER) 降解剂 (SERD)，能够作用于 ERα (IC50:48 nM) 和 ERβ (IC50:870 nM)。
T11727	JPH203 dihydrochloride KYT-0353 dihydrochloride	Others	Others
	JPH203 dihydrochloride (KYT-0353 dihydrochloride) 是一种酪氨酸类似物，可作为 L 型氨基酸转运蛋白 1 (LAT1) 的选择性抑制剂，用于癌症研究。
T12241	Norbinaltorphimine dihydrochloride nor-BNI dihydrochloride,Nor-BNI dihydrochloride,nor-Binaltorphimine dihydrochloride,Nor-Binaltorphimine dihydrochloride	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Norbinaltorphimine dihydrochloride是一种具有选择性和有效性的κ阿片受体 (κ opioid receptor) 拮抗剂，可在小鼠中诱导瘙痒相关反应。
T4676	Sardomozide dihydrochloride CGP 48664 dihydrochloride,Sardomozide dihydrochloride	Others	Others
	Sardomozide dihydrochloride (CGP 48664 dihydrochloride) 是 S-腺苷甲硫氨酸脱羧酶 (SAMDC) 的抑制剂 (IC50 = 5 nM)。
T21648	CP-31398 dihydrochloride CP 31398 dihydrochloride	p53	Apoptosis
	CP-31398 dihydrochloride 是一种 p53 稳定剂，可稳定 p53 的活性构象并促进具有突变型或野生型 p53 的癌细胞系中的 p53 活性。
T10459	Banoxantrone dihydrochloride AQ4N dihydrochloride,AZD1689 2HCl	NOS	Immunology/Inflammation
	Banoxantrone dihydrochloride (AQ4N dihydrochloride) 是一种新型缺氧细胞毒素，通过 iNOS 依赖机制选择性地杀死缺氧细胞。
T6720	Vatalanib dihydrochloride CGP-797870 dihydrochloride,ZK-222584 dihydrochloride,Vatalanib 2HCl,PTK787 dihydrochloride,Vatalanib (PTK787) 2HCl,CGP-79787 dihydrochloride,瓦他拉尼	Apoptosis; VEGFR; PDGFR	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Vatalanib dihydrochloride (PTK787 dihydrochloride) 是一种VEGFR2/KDR 的抑制剂，其IC50值为37nM。
T3597	Cutamesine dihydrochloride AGY94806 dihydrochloride,库他美新二盐酸盐,SA4503 (dihydrochloride),SA4503 dihydrochloride	Sigma receptor	GPCR/G Protein
	Cutamesine dihydrochloride (SA4503 dihydrochloride) 是一种选择性 σ1 受体激动剂，IC50值为 17.4 nM。
T5135	Flupentixol dihydrochloride 盐酸氟哌噻吨,Fupentixol Dihydrochloride,Flupenthixol dihydrochloride,(E/Z)-Flupentixol Dihydrochloride	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Flupentixol dihydrochloride 是噻克西酮类试剂，能够用于研究精神分裂症以及抗焦虑和抑郁障碍。
T26240	Surfen dihydrochloride Aminokinuride dihydrochloride,Aminoquinuride dihydrochloride,NSC-12155,Aminokinuride 2HCl,Aminoquinuride 2HCl	FGFR; Antiviral; Antibiotic	Angiogenesis; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Surfen dihydrochloride (Aminoquinuride dihydrochloride) 是一种有效的硫酸肝素小分子拮抗剂，具有抗菌和抗病毒活性，抑制炭疽致死因子、凝血因子 X 和致死因子。Surfen dihydrochloride 可抑制普通肝素和低分子量肝素的抗凝活性，抑制肝素的硫酸化和肝素裂解酶的降解。Surfen dihydrochloridn 抑制阻断硫酸乙酰肝素介导的 FGF2 结合和信号转导。Surfen 抑制 SEVI 和精液介导的 HIV 1 型感染增强。
T4327	Prexasertib dihydrochloride LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368	Apoptosis; Chk; S6 Kinase	Apoptosis; Cell Cycle/Checkpoint; MAPK; PI3K/Akt/mTOR signaling
	Prexasertib dihydrochloride (LY2606368) 是一种选择性的，ATP 竞争性的细胞周期检测点激酶 1 抑制剂，Ki 为 0.9 nM，IC50为 <1 nM。它抑制 CHK2(IC50=8 nM) 和 RSK1 (IC50=9 nM)。它引起双链 DNA 断裂和复制突变，导致细胞凋亡，有抗肿瘤活性。
T22288	(1E)-CFI-400437 dihydrochloride CFI-400437 dihydrochloride	PLK	Cell Cycle/Checkpoint
	(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) 是一种选择性和有效的 polo 样激酶 4 (PLK4) 抑制剂，IC50为 0.6 nM。它还抑制 Aurora A、 Aurora B、 KDR 和 FLT-3，IC50分别为 0.37、0.21、0.48 和 0.18 μM，具有抗增殖活性。
T11227L	Eravacycline dihydrochloride TP-434-046,TP-434 dihydrochloride	Antibacterial	Microbiology/Virology
	Eravacycline dihydrochloride (TP-434-046) 是一种有效的广谱抗菌剂，可对抗六种大肠杆菌(MIC：0.125-0.25 mg/L)。
T11500L	GSK3368715 dihydrochloride EPZ019997 dihydrochloride,GSK3368715 2HCl,EPZ019997 2HCl	Histone Methyltransferase	Chromatin/Epigenetic
	GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) 是一种具有口服活性和高效性的 I 型蛋白精氨酸甲基转移酶 (PRMTs) 抑制剂，具有抗癌和抗肿瘤活性，抑制PRMT1，PRMT3，PRMT4，PRMT6，PRMT8的活性，可用于研究晚期实体肿瘤。
T2501	Canertinib dihydrochloride CI-1033 dihydrochloride,PD-183805 dihydrochloride,Canertinib,卡奈替尼二盐酸盐	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Canertinib dihydrochloride (PD-183805 dihydrochloride) 是一种可口服的喹唑啉盐酸盐，具有潜在的抗肿瘤和放射增敏活性，抑制细胞 EGFR 和 ErbB2自身磷酸化的 IC50值分别为 7.4 和 9 nM。
T19069	TMB dihydrochloride 3,3',5,5'-四甲基联苯胺盐酸盐,BM blue dihydrochloride,Sure Blue TMB dihydrochloride,3,3',5,5'-Tetramethylbenzidine dihydrochloride	Others	Others
	TMB dihydrochloride (Sure Blue TMB dihydrochloride) 是一种免疫组化和 ELISA 的显色底物。
T11011	Dexpramipexole dihydrochloride 普拉克索杂质D,KNS-760704 dihydrochloride,R-(+)-Pramipexole dihydrochloride,右旋普拉克索二盐酸盐,(R)-Pramipexole dihydrochloride	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Dexpramipexole dihydrochloride (KNS-760704 dihydrochloride) 是一种神经保护剂，是一种弱的非麦角类多巴胺受体激动剂。
T60248	4-Aminobenzamidine dihydrochloride p-Aminobenzamidine dihydrochloride	Serine Protease	Proteases/Proteasome
	4-Aminobenzamidine dihydrochloride (p-Aminobenzamidine dihydrochloride) 是一种强胰蛋白酶 (trypsin)抑制剂，也是一种相对较弱的尿激酶型纤溶酶原激活剂 (uPA) 抑制剂 (Ki=82 μM)。4-Aminobenzamidine 可抑制 SCID 小鼠体内前列腺肿瘤的生长。
T2663	GTS-21 dihydrochloride GTS 21 dihydrochloride,DMXB-A,DMBX-anabaseine	5-HT Receptor; AChR	GPCR/G Protein; Neuroscience
	GTS-21 dihydrochloride (DMBX-anabaseine) 是一种选择性 α7 烟碱乙酰胆碱受体激动剂，具有抗炎和增强认知的活性。它也是一种拮抗剂，对人α4β2的 Ki 为20 nM，对5-HT3A 受体的 IC50为3.1 μM。
T7505	Azimilide Dihydrochloride NE-10064 Dihydrochloride,盐酸阿齐利特	Potassium Channel	Membrane transporter/Ion channel
	Azimilide Dihydrochloride (NE-10064 Dihydrochloride) 是 I(Ks) 和 I(Kr) 抑制剂，具有抗心律失常活性。
T5495	Decloxizine dihydrochloride 盐酸去氯羟嗪,UCB 1402 dihydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Decloxizine dihydrochloride (UCB 1402 dihydrochloride) 是组胺 1 受体拮抗剂。
T35328	H-1152 dihydrochloride H-1152 2HCl,H-1152 dihydrochloride	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	H-1152 dihydrochloride (H-1152 2HCl) 是 Rho 相关蛋白激酶 (ROCK) 的特异性抑制剂，IC50 为 12 nM，Ki 为 1.6 nM。 H-1152 dihydrochloride 抑制 PKA、PKC、PKG、Aurora A 和 CaMKII，IC50 值分别为 3.03 μM、5.68 μM、0.360 μM、0.745 μM 和 0.180 μM。
T6562	Latrepirdine dihydrochloride Dimebolin dihydrochloride,Latrepirdine,Latrepirdine 2HCl,Dimebolin	Beta Amyloid; 5-HT Receptor; Adrenergic Receptor; GluR; Autophagy; Histamine Receptor	Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Latrepirdine dihydrochloride (Dimebolin dihydrochloride) 是一种具有口服活性和神经活性的多种药物靶点的拮抗剂，可刺激淀粉样前体蛋白分解代谢和 β-淀粉样蛋白分泌。
T38034	MAO-IN-M30 dihydrochloride M 30 dihydrochloride	Monoamine Oxidase	Neuroscience
	MAO-IN-M30 dihydrochloride (M 30 dihydrochloride) 是一种口服活性，可通过血脑屏障的，脑选择性不可逆 MAO-A (IC50=37 nM) 和 MAO-B (IC50=57 nM) 抑制剂。MAO-IN-M30 dihydrochloride 是有效的铁螯合剂、自由基清除剂。MAO-IN-M30 dihydrochloride 对 Dexamethasone 诱导的脑细胞凋亡具有神经保护作用。MAO-IN-M30 dihydrochloride 在 MPTP 和 lactacystin 帕金森病模型中也显示出神经恢复活性。
T35528L	TD52 dihydrochloride TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl	Others	Others
	TD52 dihydrochloride (TD52 2HCl), a derivative of Erlotinib, is a potent and orally active inhibitor of protein phosphatase 2A (CIP2A). It exhibits strong anti-cancer properties by regulating the CIP2A/PP2A/p-Akt signaling pathway, resulting in the induction of apoptosis in triple-negative breast cancer (TNBC) cells. Mechanistically, TD52 dihydrochloride disrupts the binding of Elk1 to the CIP2A promoter, effectively reducing CIP2A levels. Notably, TD52 dihydrochloride demonstrates powerful anti...
T4167	Raf inhibitor 1 dihydrochloride B-Raf inhibitor 1 dihydrochloride	Raf	MAPK
	Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) 是 Raf 激酶抑制剂，对 B-RafWT、B-RafV600E 和 C-Raf 的Ki 分别为 1、1 和 0.3 nM。
T23132	Pentamidine dihydrochloride 喷他脒二盐酸盐,MP-601205 dihydrochloride	Phosphatase; Antibacterial; Antibiotic; Parasite; Antifungal	Metabolism; Microbiology/Virology
	Pentamidine dihydrochloride (MP-601205 dihydrochloride) 是一种抗微生物剂，会干扰 DNA 的生物合成。它是选择性蛋白酪氨酸磷酸酶和再生肝磷酸酶抑制剂。它可用于冈比亚锥虫病，抗锑利什曼病和卡氏肺孢子虫肺炎的研究，有抗肿瘤活性，抗菌活性。
T25268L	Coblopasvir dihydrochloride Coblopasvir dihydrochloride(1312608-46-0 Free base)	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Coblopasvir dihydrochloride 是一种泛基因型非结构蛋白 5A(NS5A)抑制剂。本品可用于慢性丙型肝炎病毒感染的研究。
T1786	Daclatasvir dihydrochloride BMS-790052 dihydrochloride,盐酸达拉他韦	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) 是有机阴离子转运多肽 1B(OATP1B) 和 OATP1B3抑制剂，IC50分别为 1.5 µM 和 3.27 µM。它也具有口服活性的 HCV NS5A 蛋白抑制剂，多种 HCV 复制子基因型的 EC50范围为 9-146 pM。
T6146	Dorsomorphin dihydrochloride BML-275 2HCl,Compound C dihydrochloride,6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶,Dorsomorphin (Compound C) 2HCl,Compound C 2HCl,BML-275 dihydrochloride	AMPK; Autophagy; TGF-beta/Smad	Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling; Stem Cells
	Dorsomorphin dihydrochloride (BML-275 2HCl) 是一种选择性和 ATP 竞争性的AMPK 抑制剂，Ki 为 109 nM。它诱导自噬，通过靶向抑制 I 型受体ALK2，ALK3和ALK6来抑制 BMP 途径。
T7309	TAS-103 dihydrochloride 6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐,TAS-103 (dihydrochloride),BMS-247615 dihydrochloride	Topoisomerase	DNA Damage/DNA Repair
	TAS-103 dihydrochloride (BMS-247615 dihydrochloride) 是可用于癌症研究的一种 DNA 拓扑异构酶 I/II 双重抑制剂。
T16524	Philanthotoxin 74 dihydrochloride PhTx-74 HCl,PhTx 74 dihydrochloride	GluR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Philanthotoxin 74 dihydrochloride 是一种 AMPAR 拮抗剂，对 GluR3 和 GluR1 的 IC50 分别为 263 和 296 nM。
T12383	PD 168568 dihydrochloride PD 168568 (dihydrochloride),二盐酸PD168568	Dopamine Receptor	GPCR/G Protein; Neuroscience
	PD 168568 dihydrochloride (PD 168568 (dihydrochloride)) 是一种口服有效的，选择性的 D4 受体拮抗剂，其 Ki 值为 8.8 nM。
T40711	H-D-Phe-Pip-Arg-pNA dihydrochloride S-2238 dihydrochloride,H-D-Phe-Pip-Arg-pNA dihydrochloride	Others	Others
	H-D-Phe-Pip-Arg-pNA dihydrochloride (S-2238 dihydrochloride), a chromogenic substrate, mimics the N-terminal fragment of the A alpha chain of fibrinogen, the native substrate of thrombin. Specifically designed for thrombin detection, H-D-Phe-Pip-Arg-pNA dihydrochloride is employed for the quantification of antithrombin-heparin cofactor (AT-III). The AT-III assay utilizing this substrate is characterized by its sensitivity, accuracy, and ease of implementation.
T2105	Veliparib dihydrochloride 维利帕尼二盐酸盐,ABT-888 dihydrochloride	PARP; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Veliparib dihydrochloride (ABT-888 dihydrochloride) 是一种PARP1和PARP2抑制剂，Ki 分别为5.2 nM 和2.9 nM。
T3213	Hematoporphyrin dihydrochloride 血卟啉二盐酸盐,Hematoporphyrin IX dihydrochloride	Apoptosis; Others; Endogenous Metabolite	Apoptosis; Metabolism; Others
	Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride) 是一种光敏剂，是血红素结合蛋白亲和色谱底物。它暴露在红光下时，可诱导 U87 胶质瘤细胞凋亡，并降低体内肿瘤的生长。
T14490	Talipexole dihydrochloride Domnin,盐酸他利克索,B-HT 920 dihydrochloride	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Talipexole dihydrochloride (Domnin) 是一种多巴胺 D2 受体激动剂、α2-肾上腺素受体激动剂和 5-HT3 受体拮抗剂，有抗帕金森病活性。
T61156	L-Lysyl-L-lysine dihydrochloride Lysyllysine dihydrochloride	Others	Others
	L-Lysyl-L-lysine dihydrochloride (Lysyllysine dihydrochloride) 是一种酶可裂解的接头。L-Lysyl-L-lysine dihydrochloride 可用作递送多种生物活性肽的简单接头。
T1791L	Ceritinib dihydrochloride LDK378 dihydrochloride,双盐酸盐色瑞替尼	IGF-1R; ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	Ceritinib dihydrochloride (LDK378 dihydrochloride) 是一种选择性的、口服具有活性的、ATP 竞争性的ALK 酪氨酸激酶抑制剂 (IC50:200 pM)。它还抑制IGF-1R (IC50:8 nM)，InsR (IC50:7 nM) 和 STK22D (IC50:23 nM)。它显示出良好的抗肿瘤作用。
TQ0126	Mirodenafil dihydrochloride SK-3530 dihydrochloride,米罗那非二盐酸盐	PDE	Metabolism
	Mirodenafil dihydrochloride 是一种磷酸二酯酶5（PDE-5）抑制剂，可作用于勃起功能紊乱的研究。
T14998	Copanlisib dihydrochloride 库潘尼西盐酸,BAY 80-6946 dihydrochloride	Apoptosis; PI3K; mTOR	Apoptosis; PI3K/Akt/mTOR signaling
	Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) 是一种选择性和 ATP 竞争性的泛 I 类 PI3K 抑制剂。它具有优越的抗肿瘤活性，对除 mTOR 以外的其他脂质和蛋白激酶的选择性也超过 2,000 倍。

化合物

Ipatasertib dihydrochloride

Cat.No: T15374

Synonym: GDC-0068 dihydrochloride,RG-7440 dihydrochloride

Target: Akt, PKA

DG172 dihydrochloride

Cat.No: T7821

Synonym: DG172 (dihydrochloride),DG-172 dihydrochloride

Target: PPAR

Lerociclib dihydrochloride

Cat.No: T11345L

Synonym: G1T38 dihydrochloride

Target: CDK

Simufilam dihydrochloride

Cat.No: T9172

Synonym: PTI-125 dihydrochloride

Target: Others

Netarsudil Dihydrochloride

Cat.No: T10358

Synonym: AR-13324 Dihydrochloride

Target: ROCK

Preq1-Dihydrochloride

Cat.No: T9012

Synonym: pre-queuosine1 Dihydrochloride

Target: Others

Levocetirizine Dihydrochloride

Cat.No: T22354

Synonym: Xyzal Dihydrochloride,(-)-Cetirizine Dihydrochloride

Target: Histamine Receptor

UAMC00039 dihydrochloride

Cat.No: T4467

Synonym: UAMC 00039 dihydrochloride

Target: Proteasome

PAβN dihydrochloride

Cat.No: T12374

Synonym: MC-207,110 dihydrochloride,Phe-Arg-β-naphthylamide dihydrochloride

Target: Others, Antibacterial

Elacestrant dihydrochloride

Cat.No: T13675

Synonym: RAD1901 dihydrochloride

Target: Estrogen/progestogen Receptor

JPH203 dihydrochloride

Cat.No: T11727

Synonym: KYT-0353 dihydrochloride

Target: Others

Norbinaltorphimine dihydrochloride

Cat.No: T12241

Synonym: nor-BNI dihydrochloride,Nor-BNI dihydrochloride,nor-Binaltorphimine dihydrochloride,Nor-Binaltorphimine dihydrochloride

Target: Opioid Receptor

Sardomozide dihydrochloride

Cat.No: T4676

Synonym: CGP 48664 dihydrochloride,Sardomozide dihydrochloride

Target: Others

CP-31398 dihydrochloride

Cat.No: T21648

Synonym: CP 31398 dihydrochloride

Target: p53

Banoxantrone dihydrochloride

Cat.No: T10459

Synonym: AQ4N dihydrochloride,AZD1689 2HCl

Target: NOS

Vatalanib dihydrochloride

Cat.No: T6720

Synonym: CGP-797870 dihydrochloride,ZK-222584 dihydrochloride,Vatalanib 2HCl,PTK787 dihydrochloride,Vatalanib (PTK787) 2HCl,CGP-79787 dihydrochloride,瓦他拉尼

Target: Apoptosis, VEGFR, PDGFR

Cutamesine dihydrochloride

Cat.No: T3597

Synonym: AGY94806 dihydrochloride,库他美新二盐酸盐,SA4503 (dihydrochloride),SA4503 dihydrochloride

Target: Sigma receptor

Flupentixol dihydrochloride

Cat.No: T5135

Synonym: 盐酸氟哌噻吨,Fupentixol Dihydrochloride,Flupenthixol dihydrochloride,(E/Z)-Flupentixol Dihydrochloride

Target: Dopamine Receptor

Surfen dihydrochloride

Cat.No: T26240

Synonym: Aminokinuride dihydrochloride,Aminoquinuride dihydrochloride,NSC-12155,Aminokinuride 2HCl,Aminoquinuride 2HCl

Target: FGFR, Antiviral, Antibiotic

Prexasertib dihydrochloride

Cat.No: T4327

Synonym: LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368

Target: Apoptosis, Chk, S6 Kinase

(1E)-CFI-400437 dihydrochloride

Cat.No: T22288

Synonym: CFI-400437 dihydrochloride

Target: PLK

Eravacycline dihydrochloride

Cat.No: T11227L

Synonym: TP-434-046,TP-434 dihydrochloride

Target: Antibacterial

GSK3368715 dihydrochloride

Cat.No: T11500L

Synonym: EPZ019997 dihydrochloride,GSK3368715 2HCl,EPZ019997 2HCl

Target: Histone Methyltransferase

Canertinib dihydrochloride

Cat.No: T2501

Synonym: CI-1033 dihydrochloride,PD-183805 dihydrochloride,Canertinib,卡奈替尼二盐酸盐

Target: EGFR

TMB dihydrochloride

Cat.No: T19069

Synonym: 3,3',5,5'-四甲基联苯胺盐酸盐,BM blue dihydrochloride,Sure Blue TMB dihydrochloride,3,3',5,5'-Tetramethylbenzidine dihydrochloride

Target: Others

Dexpramipexole dihydrochloride

Cat.No: T11011

Synonym: 普拉克索杂质D,KNS-760704 dihydrochloride,R-(+)-Pramipexole dihydrochloride,右旋普拉克索二盐酸盐,(R)-Pramipexole dihydrochloride

Target: Dopamine Receptor

4-Aminobenzamidine dihydrochloride

Cat.No: T60248

Synonym: p-Aminobenzamidine dihydrochloride

Target: Serine Protease

GTS-21 dihydrochloride

Cat.No: T2663

Synonym: GTS 21 dihydrochloride,DMXB-A,DMBX-anabaseine

Target: 5-HT Receptor, AChR

Azimilide Dihydrochloride

Cat.No: T7505

Synonym: NE-10064 Dihydrochloride,盐酸阿齐利特

Target: Potassium Channel

Decloxizine dihydrochloride

Cat.No: T5495

Synonym: 盐酸去氯羟嗪,UCB 1402 dihydrochloride

Target: Histamine Receptor

H-1152 dihydrochloride

Cat.No: T35328

Synonym: H-1152 2HCl,H-1152 dihydrochloride

Target: ROCK

Latrepirdine dihydrochloride

Cat.No: T6562

Synonym: Dimebolin dihydrochloride,Latrepirdine,Latrepirdine 2HCl,Dimebolin

Target: Beta Amyloid, 5-HT Receptor, Adrenergic Receptor, GluR, Autophagy, Histamine Receptor

MAO-IN-M30 dihydrochloride

Cat.No: T38034

Synonym: M 30 dihydrochloride

Target: Monoamine Oxidase

TD52 dihydrochloride

Cat.No: T35528L

Synonym: TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl

Target: Others

Raf inhibitor 1 dihydrochloride

Cat.No: T4167

Synonym: B-Raf inhibitor 1 dihydrochloride

Target: Raf

Pentamidine dihydrochloride

Cat.No: T23132

Synonym: 喷他脒二盐酸盐,MP-601205 dihydrochloride

Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal

Coblopasvir dihydrochloride

Cat.No: T25268L

Synonym: Coblopasvir dihydrochloride(1312608-46-0 Free base)

Target: HCV Protease

Daclatasvir dihydrochloride

Cat.No: T1786

Synonym: BMS-790052 dihydrochloride,盐酸达拉他韦

Target: HCV Protease

Dorsomorphin dihydrochloride

Cat.No: T6146

Synonym: BML-275 2HCl,Compound C dihydrochloride,6-[4-[2-(1-哌啶基)乙氧基]苯基]-3-(4-吡啶基)吡唑并[1,5-A]嘧啶,Dorsomorphin (Compound C) 2HCl,Compound C 2HCl,BML-275 dihydrochloride

Target: AMPK, Autophagy, TGF-beta/Smad

TAS-103 dihydrochloride

Cat.No: T7309

Synonym: 6-[[2-(二甲基氨基)乙基]氨基]-3-羟基-7H-茚并[2,1-C]喹啉-7-酮二盐酸盐,TAS-103 (dihydrochloride),BMS-247615 dihydrochloride

Target: Topoisomerase

Philanthotoxin 74 dihydrochloride

Cat.No: T16524

Synonym: PhTx-74 HCl,PhTx 74 dihydrochloride

Target: GluR, iGluR

PD 168568 dihydrochloride

Cat.No: T12383

Synonym: PD 168568 (dihydrochloride),二盐酸PD168568

Target: Dopamine Receptor

H-D-Phe-Pip-Arg-pNA dihydrochloride

Cat.No: T40711

Synonym: S-2238 dihydrochloride,H-D-Phe-Pip-Arg-pNA dihydrochloride

Target: Others

Veliparib dihydrochloride

Cat.No: T2105

Synonym: 维利帕尼二盐酸盐,ABT-888 dihydrochloride

Target: PARP, Autophagy

Hematoporphyrin dihydrochloride

Cat.No: T3213

Synonym: 血卟啉二盐酸盐,Hematoporphyrin IX dihydrochloride

Target: Apoptosis, Others, Endogenous Metabolite

Talipexole dihydrochloride

Cat.No: T14490

Synonym: Domnin,盐酸他利克索,B-HT 920 dihydrochloride

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor

L-Lysyl-L-lysine dihydrochloride

Cat.No: T61156

Synonym: Lysyllysine dihydrochloride

Target: Others

Ceritinib dihydrochloride

Cat.No: T1791L

Synonym: LDK378 dihydrochloride,双盐酸盐色瑞替尼

Target: IGF-1R, ALK

Mirodenafil dihydrochloride

Cat.No: TQ0126

Synonym: SK-3530 dihydrochloride,米罗那非二盐酸盐

Target: PDE

Copanlisib dihydrochloride

Cat.No: T14998

Synonym: 库潘尼西盐酸,BAY 80-6946 dihydrochloride

Target: Apoptosis, PI3K, mTOR

Cat. No.	Product Name	Target	Signaling Pathways
TN1012L	Febrifugine dihydrochloride ISF-2123,Propyldazine hydrochloride,Atensil,(+)-Febrifugine dihydrochloride,常山乙素二盐酸盐,Pildralazine dihydrochloride	Parasite	Microbiology/Virology
	Febrifugine dihydrochloride (Propyldazine hydrochloride) 是存在于常山的根和叶中的一种喹唑啉酮类生物碱，具有治疗疟疾、癌症、纤维化和炎症性疾病的活性。
T2920	Berbamine dihydrochloride Berbamine,盐酸小檗胺,dihydrochloride	Apoptosis; NF-κB; Bcr-Abl; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cytoskeletal Signaling; NF-κB; Tyrosine Kinase/Adaptors
	Berbamine dihydrochloride (Berbamine) 是源自小檗植物的天然产物，是一种NF-κB 抑制剂，具有显著的抗骨髓瘤疗效。
T4754	Pyridoxylamine dihydrochloride 盐酸吡多胺,Pyridorin,Pyridoxamine dihydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	Pyridoxylamine dihydrochloride (Pyridorin) 是一种糖基化终产物和脂质化终产物抑制剂，能够防止糖尿病引起的视网膜血管病变。
T0810	Ethambutol dihydrochloride Ethambutol 2HCl,盐酸乙胺丁醇,Emb dihydrochloride,CL40881	Antibacterial; Antibiotic; Antifungal	Microbiology/Virology
	Ethambutol dihydrochloride (CL40881) 能抗分枝杆菌，可抑制阿拉伯糖基转移酶活性来阻止细胞壁形成。
T7117	Sapropterin dihydrochloride Sapropterin Hydrochloride,6R-Tetrahydro-L-biopterin dihydrochloride,(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐,6R-BH4 dihydrochloride,盐酸沙丙蝶呤	Hydroxylase	Metabolism
	Sapropterin dihydrochloride (6R-BH4 dihydrochloride) 是一种合成的 BH4 形式，已经被批准用于 BH4 反应的 PKU 研究。
T4895	Pentane-1,5-diamine dihydrochloride 5-diamine dihydrochloride,Cadaverine dihydrochloride,1,5-戊二胺盐酸盐,Pentane-1	Endogenous Metabolite	Metabolism
	Pentane-1,5-diamine dihydrochloride (Cadaverine dihydrochloride) 是内源性代谢产物的一种。
T2219	Puromycin dihydrochloride CL13900 dihydrochloride,Puromycin 2HCl,嘌呤霉素二盐酸盐水合物,嘌呤霉素二盐酸盐	ribosome; DNA/RNA Synthesis; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Puromycin dihydrochloride (CL13900 dihydrochloride) 属于肉桂酰胺腺苷抗生素，是一种蛋白质合成的抑制剂。Puromycin dihydrochloride 通过与 RNA 结合来抑制蛋白质合成，具有抗肿瘤和抗锥虫活性。
T8790	1-Methylhistamine dihydrochloride	Endogenous Metabolite	Metabolism
	1-Methylhistamine dihydrochloride 是组胺代谢物。
T4333	Quinine dihydrochloride 盐酸奎宁,Quinine bimuriate	Others	Others
	Quinine dihydrochloride (Quinine bimuriate) 是Cinchona(Rubiaceae) 各种物种的主要生物碱。它也是一种抗疟药和肌肉松弛剂（骨骼）。
T4899	L-Histidinol dihydrochloride	Endogenous Metabolite	Metabolism
	L-Histidinol dihydrochloride 是内源性代谢产物的一种。
T4940	3-Methylhistamine dihydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	3-Methylhistamine dihydrochloride 是一种组胺的降解产物，与免疫反应有关，并在接种过疫苗的小鼠中表现出上调作用。
T19466	N8-Acetylspermidine dihydrochloride N8-乙酰基亚精胺二盐酸盐	Endogenous Metabolite	Metabolism
	N8-Acetylspermidine dihydrochloride 是一种多胺物质。
T6534	Histamine dihydrochloride 组胺二盐酸盐,peremin,Ceplene,Histamine 2HCl	Endogenous Metabolite; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Histamine dihydrochloride (Ceplene) 是 Histamine 的二盐酸形式。Histamine 是一种有机氮化合物，是一种强效的胃分泌兴奋剂，支气管平滑肌收缩剂，血管舒张剂，也是一种中枢作用的神经递质。
T0788	Spectinomycin dihydrochloride 淋必治,Spectinomycin 2HCl,盐酸奇霉素,Actinospectacin	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Spectinomycin dihydrochloride (Actinospectacin) 是一种能与细菌核糖体的30S 亚基结合，干扰蛋白质合成的抗生素。
T19394	L-hydroxylysine dihydrochloride (2S,5R)-5-Hydroxylysine dihydrochloride	Others	Others
	L-hydroxylysine dihydrochloride , is formed by posttranslational hydroxylation of some lysine residues. It is an amino acid, is exclusive to collagen protein.
TQ0109	Cephaeline dihydrochloride (-)-Cephaeline dihydrochloride,盐酸吐根酚碱,NSC 32944	P450	Metabolism
	(-)-Cephaeline (dihydrochloride) is an enantiomer of Cephaeline. Cephaeline is a selective CYP2D6 inhibitor (IC50: 121 μM).
T38541	Chitobiose dihydrochloride
	Chitobiose dihydrochloride is a chitosan oligosaccharide consisting of β-1,4-linked glucosamine units.
T22213	1,4-Diaminobutane Dihydrochloride	Others	Others
	1,4-Diaminobutane dihydrochloride, an endogenous metabolite, acts as an indicator of pollution-induced stress in higher plants: barley and rape stressed with Cr(III) or Cr(VI). In addition, 1,4-Diaminobutane dihydrochloride is an important source of GABA.
T60789	L-Cystine dihydrochloride
	L-Cystine dihydrochloride 是合成谷胱甘肽 (GSH) 的含硫前体。L-Cystine dihydrochloride 的稳态对谷胱甘肽的功能很重要。L-Cystine dihydrochloride 可用作细胞培养组分。
TN7229	Baihuaqianhuoside Praeroside	Others	Others
	Baihuaqianhuoside (Praeroside) 是一种香豆素苷。Baihuaqianhuoside 可以从西番莲和 Hindenia solanacea 的根部分离出来，是首次从 P. japonicum 身上分离出来的。Baihuaqianhuoside 在体外具有抗炎活性，可以用于炎症的研究。Baihuaqianhuoside 对1,1-二苯基-2-丙烯酰肼自由基的清除作用，以及对2,2'-偶氮双（2-脒基丙烷）二盐酸盐诱导的脂质体氧化的抑制作用。

天然产物

Febrifugine dihydrochloride

Cat.No: TN1012L

Synonym: ISF-2123,Propyldazine hydrochloride,Atensil,(+)-Febrifugine dihydrochloride,常山乙素二盐酸盐,Pildralazine dihydrochloride

Target: Parasite

Berbamine dihydrochloride

Cat.No: T2920

Synonym: Berbamine,盐酸小檗胺,dihydrochloride

Target: Apoptosis, NF-κB, Bcr-Abl, Autophagy

Pyridoxylamine dihydrochloride

Cat.No: T4754

Synonym: 盐酸吡多胺,Pyridorin,Pyridoxamine dihydrochloride

Target: Others, Endogenous Metabolite

Ethambutol dihydrochloride

Cat.No: T0810

Synonym: Ethambutol 2HCl,盐酸乙胺丁醇,Emb dihydrochloride,CL40881

Target: Antibacterial, Antibiotic, Antifungal

Sapropterin dihydrochloride

Cat.No: T7117

Synonym: Sapropterin Hydrochloride,6R-Tetrahydro-L-biopterin dihydrochloride,(6R)-5,6,7,8-四氢生物蝶呤二盐酸盐,6R-BH4 dihydrochloride,盐酸沙丙蝶呤

Target: Hydroxylase

Pentane-1,5-diamine dihydrochloride

Cat.No: T4895

Synonym: 5-diamine dihydrochloride,Cadaverine dihydrochloride,1,5-戊二胺盐酸盐,Pentane-1

Target: Endogenous Metabolite

Puromycin dihydrochloride

Cat.No: T2219

Synonym: CL13900 dihydrochloride,Puromycin 2HCl,嘌呤霉素二盐酸盐水合物,嘌呤霉素二盐酸盐

Target: ribosome, DNA/RNA Synthesis, Antibacterial, Antibiotic

1-Methylhistamine dihydrochloride

Cat.No: T8790

Target: Endogenous Metabolite

Quinine dihydrochloride

Cat.No: T4333

Synonym: 盐酸奎宁,Quinine bimuriate

Target: Others

L-Histidinol dihydrochloride

Cat.No: T4899

Target: Endogenous Metabolite

3-Methylhistamine dihydrochloride

Cat.No: T4940

Target: Others, Endogenous Metabolite

N8-Acetylspermidine dihydrochloride

Cat.No: T19466

Synonym: N8-乙酰基亚精胺二盐酸盐

Target: Endogenous Metabolite

Histamine dihydrochloride

Cat.No: T6534

Synonym: 组胺二盐酸盐,peremin,Ceplene,Histamine 2HCl

Target: Endogenous Metabolite, Histamine Receptor

Spectinomycin dihydrochloride

Cat.No: T0788

Synonym: 淋必治,Spectinomycin 2HCl,盐酸奇霉素,Actinospectacin

Target: ribosome, Antibacterial, Antibiotic

L-hydroxylysine dihydrochloride

Cat.No: T19394

Synonym: (2S,5R)-5-Hydroxylysine dihydrochloride

Target: Others

Cephaeline dihydrochloride

Cat.No: TQ0109

Synonym: (-)-Cephaeline dihydrochloride,盐酸吐根酚碱,NSC 32944

Target: P450

Chitobiose dihydrochloride

Cat.No: T38541

1,4-Diaminobutane Dihydrochloride

Cat.No: T22213

Target: Others

L-Cystine dihydrochloride

Cat.No: T60789

Baihuaqianhuoside

Cat.No: TN7229

Synonym: Praeroside

Target: Others

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