Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JPH203 dihydrochloride (KYT-0353 dihydrochloride) 是一种酪氨酸类似物,可作为 L 型氨基酸转运蛋白 1 (LAT1) 的选择性抑制剂,用于癌症研究。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,070 | 现货 | ||
2 mg | ¥ 1,580 | 现货 | ||
5 mg | ¥ 1,980 | 现货 | ||
10 mg | ¥ 2,960 | 现货 | ||
25 mg | ¥ 4,670 | 现货 | ||
50 mg | ¥ 6,660 | 现货 | ||
100 mg | ¥ 8,870 | 现货 | ||
500 mg | ¥ 17,900 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,890 | 现货 |
产品描述 | JPH203 dihydrochloride (KYT-0353 dihydrochloride) is a tyrosine analog, acts as a selective inhibitor of L-type amino acid transporter 1 (LAT1), and is used in cancer research. |
体外活性 | JPH203 (30 mM) induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells. JPH203 (0.001-100 μM) inhibits 14C-leucine (1.0 μM) uptake slightly in FOB cells with an IC50 value of 92.12 ± 10.71 μM, but potently exihibts such effects in Saos2 cells with an IC50 value of 1.31 ± 0.27 μM. JPH203 (0.01 to 30 mM, 1-4 d) potently inhibits cell proliferation in Saos2 cells in a dose- and time-dependent manner, with an IC50 of 4.09-0.09 mM, but slightly inhibits that of FOB cells, with an IC50 of 24.1-2.8 mM.JPH203 Dihydrochloride is a selective inhibitor of LAT1. JPH203 inhibits 14C-leucine uptake in S2-hLAT1 and HT-29 cells, with IC50s of 0.14 μM and 0.06 μM. JPH203 (3-1000 μM) exhibits concentration-dependent inhibitory effects on S2-hLAT1 cell growth with an IC50 of 16.4 μM. JPH203 also displays inhibitory activities against HT-29 cell growth, with an IC50 value of 4.1 μM. JPH203 (0.001-100 μM) inhibits the 14C-leucine (1.0 μM) uptake in a concentration dependent way by the YD-38 cells with an IC50 value of 0.79 ± 0.06 μM. JPH203 slightly shows such effects in normal human oral keratinocytes (NHOKs). JPH203 (0.01-30 mM, 1-4 d) completely inhibits the proliferation of YD-38 cells in a dose- and time-dependent manner. However, JPH203 slightly inhibits the proliferation of NHOKs. JPH203 (30 mM) induces apoptosis of YD-38 cells. JPH203 (3 mM) also increases the level of cleaved PARP in activation of the caspases cascade. |
体内活性 | JPH203 exhibits dose-dependent inhibition on HT-29 tumor growth in nude mice. |
别名 | KYT-0353 dihydrochloride |
分子量 | 545.24 |
分子式 | C23H21Cl4N3O4 |
CAS No. | 1597402-27-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (91.70 mM), sonification is recommended.
H2O: 10mg/mL (18.34mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 1.8341 mL | 9.1703 mL | 18.3405 mL | 45.8514 mL |
5 mM | 0.3668 mL | 1.8341 mL | 3.6681 mL | 9.1703 mL | |
10 mM | 0.1834 mL | 0.917 mL | 1.8341 mL | 4.5851 mL | |
DMSO | 20 mM | 0.0917 mL | 0.4585 mL | 0.917 mL | 2.2926 mL |
50 mM | 0.0367 mL | 0.1834 mL | 0.3668 mL | 0.917 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
JPH203 dihydrochloride 1597402-27-1 Others JPH 203 JPH-203 KYT 0353 KYT-0353 Dihydrochloride JPH-203 Dihydrochloride JPH-203 dihydrochloride KYT-0353 JPH203 Dihydrochloride KYT0353 KYT0353 Dihydrochloride KYT-0353 dihydrochloride JPH 203 Dihydrochloride KYT 0353 Dihydrochloride JPH203 Inhibitor inhibitor inhibit