36
31
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8322 |
BL-918
|
Autophagy | Autophagy |
BL-918 是一种 UNC-51 样激酶 1 的有效激活剂,EC50 为 24.14 nM。它通过靶向 ULK 复合物发挥其细胞保护性自噬作用。它有用于帕金森氏病的研究潜力。 | |||
T1414 |
Sodium 2-mercaptoethanesulfonate
Mitexan,美司那,美司钠,Uromitexan,Mesna,Mesnum,Mesnex |
Others | Others |
Sodium 2-mercaptoethanesulfonate (Uromitexan) 是一种抗氧化剂,具有细胞保护作用。它可用于减轻由环磷酰胺引起的出血性膀胱炎。它广泛用作抗化学疗法毒性的全身保护剂。 | |||
T3289 |
Amifostine
氨磷汀,Ethyol,WR2721,Gammaphos |
Others; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; Others |
Amifostine (Ethyol) 是一种广谱细胞保护剂和辐射防护剂,具有清除自由基的作用。它可选择性保护正常组织免受放射线和化学疗法造成的损害。它是有效的 HIF-α1和 p53诱导剂,可降低肾脏毒性并具有抗血管生成作用。 | |||
T6381 |
Amifostine trihydrate
Ethyol trihydrate,WR2721,三水氨磷汀,Amifostine |
Others; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; Others |
Amifostine trihydrate (WR2721) 是一种广谱细胞保护剂和辐射防护剂。它可选择性保护正常组织免受放射线和化学疗法造成的损害。它是有效的HIF-α1和p53诱导剂。它通过清除氧衍生的自由基来保护细胞免受损伤。它可降低肾脏毒性并具有抗血管生成作用。 | |||
T6919 |
Omaveloxolone
RTA-408 |
Apoptosis; Others; Nrf2; STING | Apoptosis; Immunology/Inflammation; Others |
Omaveloxolone (RTA-408) 是一种抗氧化炎症调节剂,可激活Nrf2并抑制一氧化氮。它通过抑制 STING 依赖的 NF-κb 信号通路,来抑制破骨细胞的生成。 | |||
T6710 |
Troxipide
曲昔派特,曲昔匹特,Aplace |
Others | Others |
Troxipide (Aplace) 是非分泌型胃保护剂,是口服具有活力的胃炎和胃溃疡的防御因子的增强剂,具有抗溃疡、抗炎和粘液分泌作用。 | |||
T1338 |
Sucralfate
硫糖铝,Sucrose octasulfate–aluminum complex |
FGFR; Others; Antibacterial; Prostaglandin Receptor | Angiogenesis; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Others; Tyrosine Kinase/Adaptors |
Sucralfate (Sucrose octasulfate–aluminum complex) 是一种口服活性胃保护剂。它抑制消化性活性,并与黏膜损伤时暴露的带负电荷的上皮下蛋白结合,形成一层粘性层,保护血管床和增殖区。它可用于预防和治疗胃肠道疾病。 | |||
T19763 |
Cetraxate hydrochloride
DV-1006,DV 1006,Cetraxate HCl,盐酸西曲酸酯,DV1006 |
Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism |
Cetraxate hydrochloride (DV10062) 是一种有效的顶体蛋白酶 (acrosomal proteinase acrosin) 抑制剂,Ki 和 IC50分别为 0.94 μM 和 3.3 μM。它是一种口服有活性的抗溃疡试剂 (anti-ulcer),具有粘膜保护作用,可用于研究胃溃疡。 | |||
T16865 |
SCH28080
|
ATPase; Proton pump | Membrane transporter/Ion channel |
SCH28080 是一种可逆且具有 K+ 竞争性的胃 H+/K+-ATP 酶 (H+/K+-ATPase) 抑制剂,IC50 值为 20 nM (家兔微粒体膜)。SCH28080 在体内是有效的酸分泌抑制剂,具有抗溃疡活性、抗分泌和细胞保护活性。 | |||
T0988 |
Trimetazidine dihydrochloride
盐酸曲美他嗪,Yoshimilon,Kyurinett,Vastarel F |
Autophagy; Fatty Acid Synthase | Autophagy; Metabolism |
Trimetazidine dihydrochloride (Vastarel F) 是细胞保护性抗缺血剂,也用作缺血性心脏病或心绞痛的血管扩张剂,具有抗氧化,抗炎,抗伤害和胃保护作用。它可通过抑制脂肪酸代谢提高心肌葡萄糖利用率。 | |||
T0825 |
Ebselen
SPI-1005,PZ-51,依布硒,CCG-39161 |
Phosphatase; Virus Protease; Calcium Channel; COX; HIV Protease | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Ebselen (CCG-39161) 是一种谷胱甘肽过氧化物酶模拟物,是电压依赖性钙通道阻断剂。它抑制Mpro 和COVID-19病毒,是HIV-1衣壳 CTD 二聚化的抑制剂,具有抗炎、抗癌和抗氧化活性。 | |||
T2170 |
SKF-96365 hydrochloride
1-[2-(4-甲氧基)-2-[3-(4-甲氧基苯基)丙氧基]乙基]咪唑,SKF96365 |
Apoptosis; Potassium Channel; Calcium Channel; TRP/TRPV Channel; Autophagy | Apoptosis; Autophagy; Membrane transporter/Ion channel; Metabolism |
SKF-96365 hydrochloride (SKF96365) 是store-operated Ca2+entry 抑制剂,也是TRP channel 阻滞剂。它显著抑制豚鼠离体心脏 hERG、hKCNQ1/hKCNE1、hKir2.1 和 hKv4.3 电流,延长QTc 间期。它通过诱导结直肠癌细胞的细胞周期阻滞和凋亡起抗肿瘤作用。 | |||
T34450 | Rumbrin | ||
Rumbrin is a cytoprotective compound produced by Auxarthron umbrinum. | |||
T33390 |
MIND4
MIND 4,MIND-4 |
||
Mind4 is an inducer of cytoprotective Nrf2 activity. Mind4 induces Nrf2 activation and reduces the production of reactive oxygen species and nitrogen intermediates in neurons and non neurons. | |||
T25498 |
Hexapradol
|
||
Hexapradol is a new antiulcer compound with a cytoprotective action. | |||
T40802 |
Poloxamer 188
|
||
Poloxamer 188, a nonionic linear copolymer possessing surfactant properties, demonstrates anti-thrombotic, anti-inflammatory, and cytoprotective activities across different tissue injury models. | |||
T32230 |
Isosalipurposide
Phlorizin chalcone |
||
Isosalipurposide, a chalcone compound, exerts a cytoprotective effect against oxidative injury via Nrf2 activation. | |||
T28929 |
TBE-31
TBE 31 |
||
TBE-31 is a highly potent activator of Nrf2, a liver carcinogenesis blocker and a potent phase 2 cytoprotective pathway inducer. | |||
T68374 |
8-Nitro-cGMP
|
||
8-Nitro-cGMP is a unique cytoprotective mediator which inhibits oxidative stress. 8-Nitro-cGMP is also a probe of the protein S-guanylation. | |||
T37538 |
Amifostine thiol
|
||
Amifostine thiol (WR-1065), the active metabolite of cytoprotector Amifostine, serves as a cytoprotective agent possessing radioprotective properties. It activates p53 via a JNK-dependent signaling pathway[1][2][3]. | |||
TP1123 |
IGF-I (24-41) TFA (135861-49-3 free base)
Insulin-like Growth Factor I (24-41) (TFA),IGF-I (24-41) TFA |
||
IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective actions).IGF-I (24-41) (TFA) is amino acids 24 to 41 fragment of Insulin-like Growth | |||
T11752 |
Keap1-Nrf2-IN-1
Keap1–Nrf2-IN-1 |
Src | Angiogenesis; Tyrosine Kinase/Adaptors |
Keap1–Nrf2 IN-1 activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models. Keap1–Nrf2 IN-1 is a Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 ( | |||
T12662 | (Rac)-BL-918 | Others | Others |
(Rac)-BL-918 是 BL-918 的消旋体。BL-918 是一种 UNC-51 样激酶 1 的有效激活剂,EC50 为 24.14 nM。可诱导细胞保护性自噬以治疗帕金森病。 | |||
TP1124 |
IGF-I (24-41)
Insulin-like Growth Factor I (24-41),IGF-I 24-41 |
||
IGF-I (24-41) is a 24-41 amino acid fragment of Insulin-like Growth Factor I (IGF-I). IGF-I is partly responsible for systemic GH activities although it possesses a wide number of own properties (anabolic, antioxidant, anti-inflammatory and cytoprotective | |||
T38800 |
MMPI-1154
|
||
MMPI-1154 is a highly promising imidazole-carboxylic acid (ICA) MMP-2 inhibitor (IC 50 = 6.6 μM) with excellent cardio-cytoprotective properties. It is specifically designed for the study of acute myocardial infarction. Additionally, MMPI-1154 exhibits significant inhibitory effects on MMP-13, MMP-1, and MMP-9 activities with IC 50 values of 1.8 μM, 10 μM, and 13 μM, respectively. | |||
T41251 |
Taprostene
|
||
Taprostene (CG-4203) 是一种合成的、化学稳定的前列环素 (PGI2) 类似物。Taprostene 对猫急性心肌缺血再灌注后内皮和心肌有保护作用。Taprostene 增强细胞保护作用,同时减少不必要的血液动力学影响。 | |||
T78690 |
MAO-B-IN-18
|
Monoamine Oxidase | Neuroscience |
MAO-B-IN-18是高效的选择性MAO-B抑制剂,其IC50值针对hMAO-B为52 nM,对hMAO-A则为14 μM。此外,MAO-B-IN-18能显著保护神经母细胞瘤和星形胶质细胞培养物免受过氧化氢损伤。 | |||
TP1247 |
ACTH (1-13)
Adrenocorticotropic Hormone (1-13),ACTH 1-13 |
||
ACTH (1-13) is a 13-aa peptide, with cytoprotective effects in the model of ethanol induced gastric lesions in rats.Adrenocorticotropic hormone (ACTH), also known as corticotropin, is produced and secreted by the anterior pituitary gland. ACTH is an impor | |||
T73156 | LabMol-301 | ||
LabMol-301 抑制NS5 RdRp 和NS2B-NS3pro 的活性 (IC50分别为 0.8 和 7.4 μM)。LabMol-301 具有细胞保护作用并阻止寨卡病毒 (ZIKV) 诱导的细胞死亡。 | |||
T35961 |
Prostaglandin Bx
|
||
PGBx is a mixture of oligomers of PGB1 with a molecular weight of 1,000-1,500. It has antioxidant and free radical trapping activity that was first studied in isolated mitochondria.1 PGBx has anti-inflammatory and cytoprotective activity which may be attributed to inhibition of the 14 kDa sPLA2.2,3 At a dose of 1 mg/kg, PGBx significantly reduces the incidence of ulcers in rats.2References1. Polis, B.D., Polis, E., and Kwong, S. Protection and reactivation of oxidative phosphorylation in mitocho... | |||
T64218 | Keap1-Nrf2-IN-1 TFA | ||
Keap1-Nrf2-IN-1 TFA (compound35) 是一种 Keap1-Nrf2 蛋白-蛋白相互作用抑制剂 (IC50: 43 nM),可以激活 Nrf2 调节的细胞保护反应。在细胞和体内模型中。Keap1-Nrf2-IN-1 TFA 能够拮抗对乙酰氨基酚诱导的肝损伤。 | |||
T36614 |
DL-Sulforaphane N-acetyl-L-cysteine
|
||
Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents. DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC) is a major ... | |||
T76012 |
IGF-I (30-41) (TFA)
|
||
IGF-I (30-41) (TFA) 是类胰岛素生长因子I 30 至 41 的氨基酸片段。IGF-I 对生长激素的活性有着重要的作用,但是IGF-I 本身也具有一些自身的特性,如合成代谢、抗氧化、抗炎和细胞保护作用。 | |||
T35860 |
AP39
|
||
AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP39 (30-300 nM) dose-dependently increases H2S levels in endothelial cells, predominantly in mitochondrial regions. It stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an i... | |||
T75074 | 6-Methoxypurine-9-β-D-5’(R)-C-methylriboside | ||
6-Methoxypurine-9-β-D-5’(R)-C-methylriboside 是一种嘌呤碱基,属于次黄嘌呤似物,主要在肌肉组织中发现。作为黄嘌呤在嘌呤氧化酶作用下的代谢产物,次黄嘌呤具备显著的抗炎性质,并可作为内源性 poly(ADP-ribose) polymerase (PARP) 的抑制剂。其通过抑制 PARP 活性,防止过氧亚硝酸盐引起的线粒体去极化及次级超氧化物的产生,展现出细胞保护作用。同时,次黄嘌呤也被用作缺氧的生物标志物。 | |||
T76014 |
IGF-I (24-41) (TFA)
|
||
IGF-I (24-41) TFA(Insulin-like Growth Factor I (24-41) TFA)是类胰岛素生长因子I的一个氨基酸片段,覆盖24至41位点。作为一种70个氨基酸组成的多肽激素,IGF-I TFA对神经元和神经胶质细胞具有营养作用,而且在调节全身生长激素(GH)活性中扮演关键角色。它还具备合成代谢、抗氧化、抗炎及细胞保护功能,对躯体生长及行为发育调节作用显著。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8276 |
Methyl palmitoleate
|
Others | Others |
Methyl palmitoleate 是棕榈油酸的类似物,也是一种脂肪酸甲酯,具有细胞保护性和促进生长性。 | |||
TN2259 |
Taurocholic acid
N-Choloyltaurine |
TNF; PI3K | Apoptosis; PI3K/Akt/mTOR signaling |
Taurocholic acid (N-Choloyltaurine) 是一种胆汁酸,参与脂肪的乳化。Taurocholic acid 具有细胞保护作用,可通过 PI3K 介导的途径防止肿瘤坏死因子-α 诱导的胆管细胞损伤。 | |||
T12451 |
Phosphoenolpyruvic acid tricyclohexylammonium salt
PEP 3 CHA,phosphoenolpyruvic-acid-tricyclohexylammonium-salt,phosphoenolpyruvic-acid-tricyclohexylammoniu-m-salt,磷酸烯醇丙酮酸三(环已胺)盐 |
Others | Others |
Phosphoenolpyruvic acid tricyclohexylammonium salt (PEP 3 CHA) 是一种能够透过细胞膜的糖酵解代谢物,含有高能磷酸基团,具有细胞保护和抗氧化作用。 | |||
T7792 |
Hispidin
6-[(1E)-2-(3,4-二羟基苯基)乙烯基]-4-羟基-2H-吡喃-2-酮 |
Endogenous Metabolite; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism |
Hispidin 是来自裂蹄木层孔菌的酚类天然产物,是一种 PKC 抑制剂,具有很强的抗氧化、抗癌、抗糖尿病和抗痴呆作用。 | |||
TN1711 |
Gossypetin
|
Antioxidant; p38 MAPK; MAPK; Antibacterial | MAPK; Microbiology/Virology; oxidation-reduction |
Gossypetin 是一种可从Rhodiola rosea Linn.中提取的六羟基化的类黄酮,是一种有效的 MKK3 和 MKK6 抑制剂,可强烈减弱 MKK3/6-p38 信号传导途径。Gossypetin 具有抗突变、抗动脉粥样硬化、抗氧化以及细胞保护和抗菌作用,它通过下调溶酶体酪蛋白酶 K 的活性和诱导肌动蛋白环破骨细胞中的自噬相关蛋白来抑制骨吸收。 | |||
TN1917 |
Mauritianin
|
Topoisomerase | DNA Damage/DNA Repair |
Mauritianin 是一种从 Acalypha indica 的花和叶中分离出来的山柰酚苷,是一种拓扑异构酶 I 抑制剂。Mauritianin 具有细胞保护活性。 | |||
T3761 |
1-Octacosanol
n-Octacosanol,二十八烷醇,Montanyl alcohol,Cluytyl alcohol,Octacosanol,Octacosyl alcohol,Octanosol |
Others | Others |
1-Octacosanol (Octanosol) 是直链脂肪族 28 碳脂肪醇,具有抗疲劳作用。 | |||
T37152 |
3-Methyl-2-cyclopenten-1-one
|
Endogenous Metabolite | Metabolism |
3-Methyl-2-cyclopenten-1-one 可作为食品添加剂,在 2-5 ppm 下可改善肉类和肉制品的风味。添加3-Methyl-2-cyclopenten-1-one 在对雄性Wistar 大鼠口服给药时显示出胃细胞保护活性。 | |||
TN1016 |
Kukoamine A
|
NF-κB; Lipoxygenase; DNA/RNA Synthesis; Parasite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; NF-κB |
Kukoamine A 是一种天然的精胺衍生物,具有抗癌、抗高血压、细胞保护、抗氧化和抗炎活性。它是锥虫硫磷还原酶抑制剂,Ki 值为 1.8 μM。 | |||
TN1413 |
Atranorin
荔枝素,巴美灵,荔枝素 |
Endogenous Metabolite; NO Synthase; Ras | GPCR/G Protein; Immunology/Inflammation; MAPK; Metabolism |
Atranorin 是地衣的次生代谢产物,具有显着的抗伤害、抗炎和氧化还原活性,对 H(2)O(2) 诱导的氧化应激下的细胞具有细胞保护作用。 | |||
TN3048 |
4-Methoxycinnamaldehyde
p-Methoxycinnamaldehyde |
RSV | Microbiology/Virology |
4-Methoxycinnamaldehyde (p-Methoxycinnamaldehyde) 是 Agastache rugosa 的一种活性成分。4-Methoxycinnamaldehyde 对人喉癌细胞系中的呼吸道合胞病毒 (RSV) 具有细胞保护活性,有助于控制 RSV 感染诱发的疾病,IC50 约为 0.055 μg/mL。 | |||
T3415 |
Secoisolariciresinol diglucoside
亚麻木酚素,LGM2605 |
ROS | Immunology/Inflammation |
Secoisolariciresinol diglucoside (LGM2605) 在铁过载诱导的氧化还原炎症损伤的体外模型中具有细胞保护作用。 Secoisolariciresinol Diglucoside(25 mg/kg b.w.) 通过抑制 ROS 水平介导的酶和非酶抗氧化剂水平升高来防止肝脏受到过氧化损伤,从而发挥抗高血糖作用。 | |||
T5720 |
Boldine
1,10-Dimethoxy-2,9-dihydroxyaporphine,波尔定碱,波尔定,ex Peumus boldus |
RANKL/RANK | NF-κB |
Boldine (1,10-Dimethoxy-2,9-dihydroxyaporphine) 是一种阿扑吗啡异喹啉生物碱,从山苍子根中提取获得,具有抗氧化、抗炎和细胞保护的活性。它能够抑制破骨细胞生成,并利用下调 OPG/RANKL/RANK 信号途径,改善骨破坏。它可用于研究类风湿性关节炎。 | |||
T8074 |
Esafosfan trisodium
Fosfructose trisodium,D-果糖-1,6-二磷酸三钠盐,D-Fructose-1,6-diphosphate trisodium salt octahydrate,FDP trisodium,Diphosphofructose trisodium |
Others; Endogenous Metabolite | Metabolism; Others |
Esafosfan trisodium (FDP trisodium) 是一种细胞保护性的天然糖磷酸盐,用于镰状细胞性贫血,心血管缺血和哮喘的研究。Fosfructose trisodium 通过刺激无氧糖酵解起作用,其在缺血条件下产生三磷酸腺苷。 | |||
T3426 |
Bacoside A
|
MMP; Others; TNF; Dopamine Receptor; NOS; ROS | Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience; Others; Proteases/Proteasome |
Bacoside A has a possible anticancer activity that could be inducing cell cycle arrest and apoptosis through Notch pathway in GBM in vitro. It exerts cytoprotective efficacy by attenuation of ROS generated through oxidative stress by an increase in the concentration of antioxidant enzymes and sustain membrane integrity which leads to restoring the damage caused by tBHP. Bacoside A can able to inhibit the progression of Experimental Autoimmune Encephalomyelitis (EAE) may be by the inhibition of i... | |||
T3S0509 |
Gaultherin
|
COX | Immunology/Inflammation; Neuroscience |
Gaultherin 是一种分离自 Gaultheria yunnanensis 中的天然水杨酸酯衍生物。它是一种非甾体类抗炎药,具有止痛和抗炎作用,与 Aspirin 相比没有胃溃疡作用。 | |||
T3228 |
Fosfructose
D-fructose-1,6-diphosphate,Betulanonaprenol,4937-84-2,Diphosphofructose,二磷酸果糖,Fructose 1,6-diphosphate,D-fructofuranose 1,6-bisphosphate,Esafosfan |
Others; Endogenous Metabolite | Metabolism; Others |
D-fructose-1,6-diphosphate 是一种细胞保护性的天然糖磷酸盐,Fosfructose 通过刺激无氧糖酵解起作用,其在缺血条件下产生三磷酸腺苷,有潜力用于心血管缺血,镰状细胞性贫血和哮喘的研究。 | |||
T6429 |
Caffeic Acid Phenethyl Ester
Phenylethyl Caffeate,咖啡酸苯乙酯,CAPE |
Apoptosis; NF-κB | Apoptosis; NF-κB |
Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) 是咖啡酸的苯乙醇酯,是蜂巢蜂胶的生物活性成分。它抑制核转录因子 NF-kappa B 的激活,具有抗肿瘤、细胞保护和免疫调节活性。它抑制 PDGF 诱导的血管平滑肌细胞增殖。 | |||
TN2249 | (+)-Syringaresinol | Sirtuin; Antifection | Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology |
(+)-Syringaresinol shows antioxidant potential, it exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2. | |||
TN6510 |
Cordifolioside A
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Cordifolioside A possesses immunomodulatory activity, it has a potential in vivo radioprotective effect as well as in vitro cytoprotective activity. | |||
TN1670 |
Ganodermanondiol
灵芝酮二醇 |
HIV Protease; Nrf2; AMPK | Chromatin/Epigenetic; Immunology/Inflammation; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK. | |||
TN1366 |
Alcesefoliside
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Others | Others |
Alcesefoliside has statistically significant cytoprotective activity similar to that of silymarin, tested at 60 ug/mL. | |||
TN1269 |
3β-Methoxy-2,3-dihydrowithaferin A
3beta-甲氧基-2,3-二氢醉茄素A,3beta-Methoxy-2,3-dihydrowithaferin A |
MAPK; Akt | Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling |
3beta-Methoxy-2,3-dihydrowithaferin A has cytoprotective activity, it protects normal cells against stress. | |||
TN1578 |
Dihydroconiferyl alcohol
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Others | Others |
Dihydroconiferyl alcohol exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2. | |||
TN4426 |
Leojaponin
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AChR | Neuroscience |
Leojaponin is a prolyl oligopeptidase (POP) inhibitor. Leojaponin exhibits significant cytoprotective activities against glutamate-induced toxicity at concentrations ranging from 0.1 microm to 10 microm. | |||
TN2936 |
3-Hydroxy-11-ursen-28,13-olide
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Others | Others |
3β-Hydroxy-urs-11-en-28,13β-olide shows a potent concentration-independent cytoprotective effect against CCl4-induced injury on human hepatoma cell line relative to silymarin as a reference standard. It exhibits weak-moderate antiproliferative activity ag | |||
T81532 |
Pedaliin 6''-acetate
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Pedaliin 6''-acetate (compound 10) 为甘青青兰中分离得到的天然产物,具有抗氧化活性,并能对抗DOX诱导的H9c2心肌细胞毒性,表现出细胞保护效应,其EC50为19.1 μM。 | |||
TN5369 |
Dehydroleucodine
Dehydroleucodin |
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Dehydroleucodine has antidiarrheal, anti-inflammatory, anti-microbial, embryotoxicity, gastric cytoprotective, anti-cancer activities. Dehydroleucodine has an important inhibitory effect in cellular pathways regulating adipocyte differentiation by modulat | |||
T83319 |
4-epi-Withaferin A
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4-epi-Withaferin A(化合物28)是Withaferin A的一个类似物,它增强了细胞毒性及细胞保护性热休克诱导活性(HSA)。此外,4-epi-Withaferin A还展现了通过激活细胞防御机制来研究蛋白质聚集相关疾病的潜力。 | |||
T29078 |
Ursodeoxycholic acid sodium
UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,熊去氧胆酸钠盐,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium |
FXR; Endogenous Metabolite; GPCR19 | GPCR/G Protein; Metabolism |
Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) 是一种天然存在的次级胆汁酸,具有抗炎和细胞保护活性。Ursodeoxycholic acid sodium 作为信号分子,通过与胆汁酸激活受体相互作用发挥其作用,包括 G 蛋白偶联胆汁酸受体 5 (TGR5) 和法尼醇 X 受体 (FXR)。 | |||
TN4635 | Neoechinulin A | NADPH-oxidase; Beta Amyloid; ASK; IκB/IKK; p38 MAPK; TNF; NOS; NF-κB; COX; Prostaglandin Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; Neuroscience; NF-κB |
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regu |