Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ebselen (CCG-39161) 是一种谷胱甘肽过氧化物酶模拟物,是电压依赖性钙通道阻断剂。它抑制Mpro 和COVID-19病毒,是HIV-1衣壳 CTD 二聚化的抑制剂,具有抗炎、抗癌和抗氧化活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 387 | 现货 | ||
10 mg | ¥ 555 | 现货 | ||
25 mg | ¥ 877 | 现货 | ||
100 mg | ¥ 1,978 | 现货 | ||
200 mg | ¥ 2,655 | 现货 |
产品描述 | Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced by reactive oxygen species (ROS). In addition, this agent inhibits the activity of a variety of enzymes including nitric oxide synthase (NOS), 5-lipoxygenase, cyclooxygenase, protein kinase C (PKC), NADPH oxidase and gastric H+/K+-ATPase. Furthermore, ebselen may be neuroprotective due to its ability to neutralize free radicals upon NMDA receptor activation thus, reducing lipoperoxidation mediated by glutamate-induced excitotoxicity. |
靶点活性 | Mpro:0.67 μM (IC50), COVID-19 virus:4.67 μM (EC50) |
别名 | SPI-1005, PZ-51, 依布硒, CCG-39161 |
分子量 | 274.18 |
分子式 | C13H9NOSe |
CAS No. | 60940-34-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mM
H2O: Insoluble
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.6472 mL | 18.2362 mL | 36.4724 mL | 91.181 mL |
5 mM | 0.7294 mL | 3.6472 mL | 7.2945 mL | 18.2362 mL | |
10 mM | 0.3647 mL | 1.8236 mL | 3.6472 mL | 9.1181 mL | |
20 mM | 0.1824 mL | 0.9118 mL | 1.8236 mL | 4.559 mL | |
50 mM | 0.0729 mL | 0.3647 mL | 0.7294 mL | 1.8236 mL | |
100 mM | 0.0365 mL | 0.1824 mL | 0.3647 mL | 0.9118 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ebselen 60940-34-3 Immunology/Inflammation Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience Proteases/Proteasome Phosphatase Virus Protease Calcium Channel COX HIV Protease voltage-dependent IMPase Ca channels VDCC peroxidase COVID-19 SPI-1005 C145 HIV blood-brain PZ-51 QSOX1 inositol monophosphatase Ca2+ channels Human immunodeficiency virus 依布硒 Mpro barrier glutathione SPI1005 SPI 1005 Inhibitor PZ51 CCG-39161 CCG39161 CCG 39161 PZ 51 inhibit mimetic inhibitor