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Taprostene

产品编号 T41251 CAS 108945-35-3

Taprostene (CG-4203) 是一种合成的、化学稳定的前列环素 (PGI2) 类似物。Taprostene 对猫急性心肌缺血再灌注后内皮和心肌有保护作用。Taprostene 增强细胞保护作用，同时减少不必要的血液动力学影响。

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Taprostene, CAS 108945-35-3

规格	价格/CNY		货期	数量
1 mg	￥ 2,970		35日内发货

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生物活性

化学信息

存储 & 溶解度

产品描述

Taprostene (CG-4203), a synthetic and chemically stable analogue of Prostacyclin (PGI2), effectively protects the endothelium and myocardium following acute myocardial ischemia and reperfusion in cats. It enhances cytoprotective actions and minimizes undesired hemodynamic effects [1].

体内活性

Taprostene (100 ng/kg/min) is infused intravenously starting 30 minutes postocclusion of the left anterior descending coronary artery followed by reperfusion 1 hour later in a 6-hour model of myocardial ischemia (MI) with reperfusion in anesthetized cats. Taprostene infusion causes significantly decrease plasma creatine phosphokinase activities for the MI + Taprostene group compared with the MI + vehicle group.Taprostene has a profile of activity including prevention of aggregation in cat platelets15 at concentrations that are much lower than that required to produce significant vasodilator activity in rabbit aortic rings. In addition to antiaggregatory and cytoprotective effects in circulatory shock, Taprostene exerts beneficial effects in acute inflammatory states and in rat models of myocardial hypoxia and permanent ischemia.A variety of infusion rates of Taprostene from 50 to 200 ng/kg/min were initially used to obtain an infusion rate that produced minimal hemodynamic (i.e., vasodilator) effects but still exerted cardioprotective effects. Taprostene treatment inhibits neutrophils adhering to the myocardial endothelium in both jeopardized and necrotic myocardial tissue after ischemia and reperfusion [1]. Animal Model: Adult male cats (2.5-3.5 kg) [1] Dosage: 100 ng/kg Administration: Infused intravenously at a rate of 100 ng/kg/min until the end of the experiment (i.e., for 5.5 hours). Result: In six cat aortic rings, 1-100 ng/mL failed to exert any vasorelaxant effect. Relaxed the vascular rings 34% at 300 ng/mL. The EC 50 was 520 ng/mL, a value 26 times that of its antiplatelet aggregatory effect in cat platelet-rich plasma.

分子量	398.49
分子式	C24H30O5
CAS No.	108945-35-3

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

计算器

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剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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