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Cordifolioside A

产品编号 TN6510 CAS 155179-20-7

Cordifolioside A possesses immunomodulatory activity, it has a potential in vivo radioprotective effect as well as in vitro cytoprotective activity.

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Cordifolioside A, CAS 155179-20-7

规格	价格/CNY		货期	数量
10 mg	￥ 3,870		待询

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天然产物信息

生物活性

化学信息

存储 & 溶解度

参考文献

植物来源	天然产物 > 防己科 > 青牛胆属
结构类型	天然产物 > 其他

产品描述

Cordifolioside A possesses immunomodulatory activity, it has a potential in vivo radioprotective effect as well as in vitro cytoprotective activity.

体外活性

Tinospora cordifolia mentioned as 'Rasayana' is extensively used in various herbal preparations for the treatment of different ailments for its general tonic, antiperiodic, antispasmodic, antiinflammatory, antiarthritic, antiallergic and antidiabetic properties. It is extensively used in Ayurveda due to its potential in improving the immune system and the body resistance against infections. The aim of the study was to isolate and characterise the immunomodulatory active compounds of Tinospora cordifolia. METHODS AND RESULTS:The immunomodulatory activity of different extracts, fractions and isolated compounds in relation to phagocytosis and reactive oxygen species production in human neutrophil cells have been investigated using the PMN phagocytic function studies, NBT, NO and chemiluminescence assay. The results obtained indicate that ethyl acetate, water fractions and hot water extract exhibited significant immunomodulatory activity with an increase in percentage phagocyctosis. Chromatographic purification of these fraction led to the isolation of a mixture of two compounds 2, 3 isolated for the first time from natural source and five known compounds 1, 4-7 which were characterized as 11-hydroxymustakone (2), N-methyl-2-pyrrolidone (3), N-formylannonain (1), Cordifolioside A (4), magnoflorine (5), tinocordiside (6), syringin (7) by nuclear magnetic resonance (NMR) and mass spectrometry (MS) and comparing the spectral data with reported one. Cordifolioside A and syringin have been reported to possess immunomodulatory activity. Other five compounds showed significant enhancement in phagocytic activity and increase in nitric oxide and reactive oxygen species generation at concentration 0.1-2.5 μg/ml. CONCLUSIONS:Seven immunomodulatory active compounds belonging to different classes have been isolated and characterised indicating that the immunomodulatory activity of Tinospora cordifolia may be attributed to the synergistic effect of group of compounds.

分子量	504.48
分子式	C22H32O13
CAS No.	155179-20-7

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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参考文献

1. Immunomodulatory active compounds from Tinospora cordifolia. J Ethnopharmacol. 2012 Jun 14;141(3):918-26.

剂量换算

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请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

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