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Search Results for " antigen "

293

抑制剂 & 化合物

47

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1286	Carcinoembryonic Antigen CEA 癌胚抗原	Others	Others
	Carcinoembryonic Antigen CEA 是一种广谱性肿瘤标志物，是大肠癌组织产生的一种糖蛋白，作为抗原可引起患者的免疫反应。
TP1830L	SV40 large T antigen NLS acetate	Others	Others
	SV40 large T antigen NLS acetate 是从大 T 抗原残基 47 到 55，使蛋白质进入细胞核。
TP1830	SV40 large T antigen NLS
	SV40 large T antigen NLS is from Large T antigen residue 47 to 55, enables protein import into cell nucleus. This peptide is generated from Large T antigen residue 47 to 55.
T23407	surface antigen (208-215) [Hepatitis B Virus]	Others	Others
	The nucleocapsid of the hepatitis B virus is covered by an envelope of HBV surface antigen (HBsAg), which has the common, group-specific determinant a. The four major subtypes of HBsAg, adw, adr, ayw and ayr, are generated, and they have been proposed to
TP2183	Large T antigen - rhesus polyomavirus 560-568	Others	Others
	Large T antigen - rhesus polyomavirus 560-568 has a peptide sequence of Ser-Glu-Phe-Leu-Leu-Glu-Lys-Arg-Ile. T antigen is required for viral DNA replication, transcription, and virion assembly.
TP2270	MHC class II antigen (45-57) [Homo sapiens]	Others	Others
	MHC class II antigen (45-57) [Homo sapiens] is a peptide with the sequence H2N-Asp-Leu-Asp-Lys-Lys-Glu-Thr-Val-Trp-His-Leu-Glu- Glu-OH, MW= 1868.07. MHC (major histocompatibility complex) class II molecules are found only on antigen-presenting cells and l
T80552	Prostate Specific Antigen Substrate
	Prostate Specific Antigen Substrate为前列腺特异性抗原（PSA）的荧光底物，专用于检测PSA的酶活性。
T81883	MAGE-3 Antigen (167-176) (human)
	MAGE-3 Antigen (167-176) (human) 是一个由 MAGE-A3 编码并与 HLA-B44 抗原结合的人类抗原决定簇，包含8个氨基酸的多肽序列。
T3160	HUHS015	Others	Others
	HUHS015 是高效的PCA-1/ALKBH3抑制剂。它对 PCA-1 作用的IC50值为 0.67 μM。
T8697	ZAP-180013	Tyrosine Kinases; Tyrosinase	Proteases/Proteasome; Tyrosine Kinase/Adaptors
	ZAP-180013 是ZAP-70抑制剂，IC50=1.8 μM。它能够抑制 ZAP-70SH2 结构域与基于免疫受体酪氨酸的激活基序的相互作用。
T2340	AC1NS4RE	Tyrosinase	Proteases/Proteasome
	是一种化学合成中的砌块
T8995	NCGC00262650	Others; Src	Angiogenesis; Others; Tyrosine Kinase/Adaptors
	NCGC00262650 是 AMA1-RON2 相互作用和 c-Src 酪氨酸激酶活性的抑制剂。
T27527	HBF-0259 HBF 0259	Antiviral	Immunology/Inflammation
	HBF-0259 是有效的乙型肝炎病毒表面抗原分泌选择性抑制剂，在 HepG2.2.15 细胞中的 EC50为 1.5 μM。
TP2412	Tanurmotide Human lymphocyte antigen 6k-(101-111)-peptide.,Arg-tyr-cys-asn-leu-glu-gly-pro-pro-ile
	Tanurmotide is a bioactive chemical.
T7954	YM976	PDE	Metabolism
	YM976 是磷酸二酯酶 4 抑制剂(IC50:2.2 nM)。它能够抑制抗原诱导的气道反应，并有抗炎的作用。
T1938	FLT3-IN-2	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	FLT3-IN-2 是 FLT3 抑制剂(IC50＜1 μM)。
T11298	FLT3-IN-3	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	FLT3-IN-3 是 FLT3抑制剂，能够抑制 FLT3 WT (IC50:13 nM) 和 FLT3 D835Y (IC50:8 nM) 。
T4428	CCT241736	FLT; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	CCT241736 是一种口服生物可利用的双重 FLT3/Aurora 激酶抑制剂，还抑制临床相关的 FLT3 耐药突变体，包括 FLT3-ITD 和 FLT3。它是 CCT137690 的高级类似物，是治疗人类恶性肿瘤的临床前开发候选物。
T4348	Syk Inhibitor II	5-HT Receptor; Syk	Angiogenesis; GPCR/G Protein; Neuroscience; Tyrosine Kinase/Adaptors
	Syk Inhibitor II 是一种可渗透细胞、具有 ATP 竞争性的嘧啶-甲酰胺化合物，可选择性且可逆地抑制 Syk，IC50为 41 nM。
T2272	BPR1J-097 BPR1J097	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	BPR1-J097 是新型的、强效的FLT3抑制剂 (IC50:11 nM)。
T6756	AMG 925	FLT; CDK	Angiogenesis; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	AMG 925 是一种选择性FLT3/CDK4双重抑制剂，IC50分别为 1 nM 和 3 nM。
T15335	FN-1501	FLT; CDK	Angiogenesis; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	FN-1501 是一种有效的 FLT3 和 CDK 抑制剂，具有抗肿瘤的活性，对 CDK2/cyclin A、CDK4/cyclin D1、CDK6/cyclin D1 和 FLT3 的 IC50值分别为 2.47、0.85、1.96 和 0.28 nM。
T4507	Chlorphenesin Adermykon,Chlorophenesin,Gecophen,氯苯甘醚	Antibacterial; Antifungal; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Chlorphenesin (Chlorophenesin) 是一种抗原相关免疫抑制剂，可抑制 IgE 介导的组胺释放。它也用作抗真菌剂，用于许多眼保健化妆品中。
T6138	TCS 359 FLT3 Inhibitor	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	TCS 359 (FLT3 Inhibitor) 是 2-酰基氨基噻吩-3-甲酰胺，是选择性FLT3抑制剂(IC50:42 nM)，能够抑制 MV4-11 细胞增殖(IC50:340 nM)。
T3065	TG101209	Apoptosis; FLT; c-RET; JAK; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	TG101209 是一种选择性有效的 JAK2抑制剂，IC50值为 6 nM。它能抑制 Flt3和RET 的活性，IC50值分别为 25 nM 和 17 nM。
T6020	Pacritinib SB1518	FLT; Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Pacritinib (SB1518) 是一种野生型 JAK2和 JAK2V617F 突变型抑制剂，IC50分别为 23 和 19 nM。它也抑制 FLT3及其突变型 FLT3D835Y，IC50分别为 22 和 6 nM。
T9473	4SC-203	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	4SC-203 是一种具有潜在的抗肿瘤活性的多激酶抑制剂。它对 FLT3/STK1、 FLT3 的突变形式以及 VEGFRs 具有选择性抑制作用。
T7673	ATH686 ATH 686	Apoptosis; FLT	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	ATH686 是一种选择性的，ATP 竞争性的FLT3抑制剂，具有抗白血病作用。它靶向突变 FLT3 蛋白激酶活性，并通过诱导凋亡和抑制细胞周期来抑制具有 FLT3 突变的细胞的增殖。
T8317	5'-Fluoroindirubinoxime 5'-FIO	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	5'-Fluoroindirubinoxime (5'-FIO) 是一种 Indirubin 的衍生物，是一种 FLT3 的抑制剂(IC50:15 nM)。
TQ0235	AC710	FLT; PDGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	AC710是一种 PDGFR 抑制剂，能够作用于 FLT3 (Kd:0.6)，CSF1R (Kd:1.57)，KIT (Kd:1)，PDGFRα (Kd:1.3) 和 PDGFRβ (Kd:1.0)。
T2640	Rebastinib DCC2036,DCC 2036,DCC-2036	Apoptosis; FLT; Bcr-Abl; Src	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Rebastinib (DCC-2036) 是一种口服有效的，非 ATP 竞争性的 Bcr-Abl 抑制剂，作用于 Abl1WT 和 Abl1T315I，IC50分别为 0.8 nM 和 4 nM，还抑制 LYN、SRC、HCK、FGR、FLT3、KDR 和 Tie-2，对 c-Kit 的活性低。Rebastinib 对 Angiopoietin2-Tie2通路具有抑制作用。
T38562	AKN-028	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	AKN-028 是酪氨酸激酶 FLT3的抑制剂，可剂量依赖性的诱导 FLT3的自磷酸化。
T6115	Fostamatinib R788,福他替尼	FLT; Syk; Monoamine Transporter; Adenosine Receptor	Angiogenesis; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience; Tyrosine Kinase/Adaptors
	Fostamatinib (R788) 是一种口服具有活力的 R406 前药。其中R406 是具有口服活性的，有效的，ATP 竞争性的Syk/FLT3抑制剂(Ki:30 nM，IC50:41 nM)，也能够抑制 Lyn (IC50:63 nM) 和 Lck (IC50:37 nM)。
T4409	Gilteritinib 吉列替尼,ASP2215	FLT; TAM Receptor; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Gilteritinib (ASP2215) 是一种 FLT3 抑制剂 (IC50:0.29 nM)，也是一种 AXL 抑制剂 (IC50:0.73 nM)，具有 ATP 竞争性。
T3455	Merestinib LY2801653	Discoidin Domain Receptor (DDR); FLT; c-Met/HGFR; ROS; ROS Kinase	Angiogenesis; Immunology/Inflammation; Tyrosine Kinase/Adaptors
	Merestinib (LY2801653) 是一种有效的口服生物可利用的具有抗肿瘤活性的c-Met 抑制剂。
T2341	KW-2449 KW2449	Apoptosis; FGFR; FLT; JAK; Bcr-Abl; Src; c-Kit; Aurora Kinase	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	KW-2449是一种多靶点激酶抑制剂，对FLT3，ABL，ABLT315I 和极光激酶的IC50值分别为6.6，14，4 和 48 nM。
T16144	MRX-2843 UNC2371	Others; FLT	Angiogenesis; Others; Tyrosine Kinase/Adaptors
	MRX-2843 (UNC2371) 是ATP 竞争性的、具有口服活性的MERTK 和FLT3酪氨酸激酶抑制剂 (TKI)，它们的IC50分别为 1.3 nM 和 0.64 nM。
T2620	G-749 G749	Apoptosis; FLT; c-RET; TAM Receptor; Aurora Kinase	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	G-749 是一种新型 FLT3 抑制剂，对 FLT3 野生型和突变体有持续的抑制作用，IC50值分别为 0.4 nM 和 0.6 nM。它可用于急性髓系白血病的耐药研究。
T6350	CHIR-124 CHIR124,CHIR 124	Apoptosis; GSK-3; FLT; Chk; PDGFR; Src	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	CHIR-124 是一种选择性 Chk1抑制剂，IC50值为 0.3 nM，可有效抑制 PDGFR 和 FLT3，IC50值分别为 6.6 nM 和 5.8 nM。
T7007	UNC2025 mrx-6313,UNC-2025,UNC 2025	FLT; TAM Receptor	Angiogenesis; Tyrosine Kinase/Adaptors
	UNC2025 (mrx-6313) 是高效的、具有口服活性的、ATP 竞争性的Mer/Flt3双抑制剂，IC50值分别为 0.74 nM 和 0.8 nM。它对MERTK 的选择性比 Axl 高 45 倍(IC50:122 nM;Ki:13.3 nM)。它具有良好的 PK 特性，可用于研究急性白血病。
T6174	R406 R-406 besylate	Apoptosis; FLT; Syk	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	R406 (R-406 besylate) 是一种具有口服活性的 ATP 竞争性 Syk/FLT3抑制剂，Ki 为 30 nM。它有效抑制 Syk 激酶活性，IC50为 41 nM。它还抑制 Lyn 和 Lck，IC50值分别为 63 nM 和 37 nM。它可减轻免疫复合物介导的炎症。
T1836	AZD2932	VEGFR; FLT; PDGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	AZD2932是一种多靶点激酶抑制剂，细胞试验中能够抑制 VEGFR2 (IC50:8 nM)，PDGFβ (IC50:4 nM)，PDGFβ (IC50:7 nM) 和 PDGFβ (IC50:9 nM)。
T2638	Gandotinib LY2784544	VEGFR; FGFR; FLT; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Gandotinib (LY2784544) 是一种JAK2抑制剂，IC50为 3 nM。它也抑制FLT3、FLT4、FGFR2、TYK2 和 TRKB，IC50分别为 4、25、32、44 和 95 nM。
T0093L	Sorafenib 索拉非尼,Bay 43-9006	Apoptosis; Raf; VEGFR; FLT; Ferroptosis; PDGFR; c-Kit; Autophagy	Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors
	Sorafenib (Bay 43-9006) 是一种多激酶抑制剂，抑制 Raf-1、B-Raf、VEGFR2、VEGFR3、VEGFR4、PDGFRβ、FLT3、c-Kit 等 (IC50=6/22/90/15/20/20/57/58 nM)，具有口服活性。Sorafenib 具有抗肿瘤活性，可以诱导细胞自噬和凋亡，也可以激动铁死亡。
T2054	Altiratinib DCC-2701	VEGFR; Tie-2; FLT; Trk receptor; c-Met/HGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Altiratinib (DCC-2701) 是一种多靶点激酶抑制剂，能够抑制 MET (IC50:2.7 nM)，TIE2 (IC50:8 nM)，VEGFR2 (IC50:9.2 nM)，FLT3 (IC50:9.3 nM)，Trk1 (IC50:0.85 nM)，Trk2 (IC50:4.6 nM) 和 Trk3 (IC50:0.83 nM)。
T3068	AT9283 J-504568	Apoptosis; FLT; JAK; Bcr-Abl; Aurora Kinase; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	AT9283 (J-504568) 是一种多靶点激酶抑制剂，抑制多种实体瘤在体内外的生长和存活，有效抑制Aurora A/B，JAK2/3，Abl (T315I)，和Flt3，IC50值范围为 1-30 nM。
T9027	CA-4948 Emavusertib	IRAK; FLT	Angiogenesis; Immunology/Inflammation; NF-κB; Tyrosine Kinase/Adaptors
	CA-4948 (Emavusertib) 是一种IRAK4抑制剂，也是一种FLT3抑制剂，具有抗肿瘤作用。
T2358	ENMD-2076	Apoptosis; VEGFR; FGFR; FLT; c-RET; PDGFR; Src; Aurora Kinase	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	ENMD2076是一种多靶点激酶抑制剂，抑制Aurora A、Flt3、KDR/VEGFR2、Flt4/VEGFR3、FGFR1、FGFR2、Src、PDGFRα的IC50值分别为1.86、14、58.2、15.9、92.7、70.8、20.2 and 56.4 nM。
T2467	R406 free base R406 (free base)	Apoptosis; FLT; Syk	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	R406 free base (R406(free base)) 是一种具有口服活性的，ATP 竞争性的Syk/FLT3抑制剂，Ki 为 30 nM。它有效抑制 Syk 激酶活性，IC50为 41 nM，可减轻免疫复合物介导的炎症。它还抑制 Lyn 和 Lck，IC50分别为 63 nM 和 37 nM。
T2677	Crenolanib ARO 002,CP-868596	FLT; PDGFR; Autophagy	Angiogenesis; Autophagy; Tyrosine Kinase/Adaptors
	Crenolanib (ARO 002) 是一种口服生物可利用的 III 型酪氨酸激酶抑制剂，抑制 FLT3和 PDGFRα/β的 IC50分别为 4、11和 3.2 nM。

化合物

Carcinoembryonic Antigen CEA

Cat.No: TP1286

Synonym: 癌胚抗原

Target: Others

SV40 large T antigen NLS acetate

Cat.No: TP1830L

Target: Others

SV40 large T antigen NLS

Cat.No: TP1830

surface antigen (208-215) [Hepatitis B Virus]

Cat.No: T23407

Target: Others

Large T antigen - rhesus polyomavirus 560-568

Cat.No: TP2183

Target: Others

MHC class II antigen (45-57) [Homo sapiens]

Cat.No: TP2270

Target: Others

Prostate Specific Antigen Substrate

Cat.No: T80552

MAGE-3 Antigen (167-176) (human)

Cat.No: T81883

Cat.No: T3160

Target: Others

Cat.No: T8697

Target: Tyrosine Kinases, Tyrosinase

Cat.No: T2340

Target: Tyrosinase

Cat.No: T8995

Target: Others, Src

Cat.No: T27527

Synonym: HBF 0259

Target: Antiviral

Cat.No: TP2412

Synonym: Human lymphocyte antigen 6k-(101-111)-peptide.,Arg-tyr-cys-asn-leu-glu-gly-pro-pro-ile

Cat.No: T7954

Target: PDE

Cat.No: T1938

Target: FLT

Cat.No: T11298

Target: FLT

Cat.No: T4428

Target: FLT, Aurora Kinase

Syk Inhibitor II

Cat.No: T4348

Target: 5-HT Receptor, Syk

Cat.No: T2272

Synonym: BPR1J097

Target: FLT

Cat.No: T6756

Target: FLT, CDK

Cat.No: T15335

Target: FLT, CDK

Cat.No: T4507

Synonym: Adermykon,Chlorophenesin,Gecophen,氯苯甘醚

Target: Antibacterial, Antifungal, Histamine Receptor

Cat.No: T6138

Synonym: FLT3 Inhibitor

Target: FLT

Cat.No: T3065

Target: Apoptosis, FLT, c-RET, JAK, Autophagy

Cat.No: T6020

Synonym: SB1518

Target: FLT, Tyrosine Kinases, JAK

Cat.No: T9473

Target: FLT

Cat.No: T7673

Synonym: ATH 686

Target: Apoptosis, FLT

5'-Fluoroindirubinoxime

Cat.No: T8317

Synonym: 5'-FIO

Target: FLT

Cat.No: TQ0235

Target: FLT, PDGFR, c-Kit

Cat.No: T2640

Synonym: DCC2036,DCC 2036,DCC-2036

Target: Apoptosis, FLT, Bcr-Abl, Src

Cat.No: T38562

Target: FLT

Cat.No: T6115

Synonym: R788,福他替尼

Target: FLT, Syk, Monoamine Transporter, Adenosine Receptor

Cat.No: T4409

Synonym: 吉列替尼,ASP2215

Target: FLT, TAM Receptor, c-Kit

Cat.No: T3455

Synonym: LY2801653

Target: Discoidin Domain Receptor (DDR), FLT, c-Met/HGFR, ROS, ROS Kinase

Cat.No: T2341

Synonym: KW2449

Target: Apoptosis, FGFR, FLT, JAK, Bcr-Abl, Src, c-Kit, Aurora Kinase

Cat.No: T16144

Synonym: UNC2371

Target: Others, FLT

Cat.No: T2620

Synonym: G749

Target: Apoptosis, FLT, c-RET, TAM Receptor, Aurora Kinase

Cat.No: T6350

Synonym: CHIR124,CHIR 124

Target: Apoptosis, GSK-3, FLT, Chk, PDGFR, Src

Cat.No: T7007

Synonym: mrx-6313,UNC-2025,UNC 2025

Target: FLT, TAM Receptor

Cat.No: T6174

Synonym: R-406 besylate

Target: Apoptosis, FLT, Syk

Cat.No: T1836

Target: VEGFR, FLT, PDGFR, c-Kit

Cat.No: T2638

Synonym: LY2784544

Target: VEGFR, FGFR, FLT, JAK

Cat.No: T0093L

Synonym: 索拉非尼,Bay 43-9006

Target: Apoptosis, Raf, VEGFR, FLT, Ferroptosis, PDGFR, c-Kit, Autophagy

Cat.No: T2054

Synonym: DCC-2701

Target: VEGFR, Tie-2, FLT, Trk receptor, c-Met/HGFR

Cat.No: T3068

Synonym: J-504568

Target: Apoptosis, FLT, JAK, Bcr-Abl, Aurora Kinase, Autophagy

Cat.No: T9027

Synonym: Emavusertib

Target: IRAK, FLT

Cat.No: T2358

Target: Apoptosis, VEGFR, FGFR, FLT, c-RET, PDGFR, Src, Aurora Kinase

Cat.No: T2467

Synonym: R406 (free base)

Target: Apoptosis, FLT, Syk

Cat.No: T2677

Synonym: ARO 002,CP-868596

Target: FLT, PDGFR, Autophagy

Cat. No.	Product Name	Target	Signaling Pathways
T82856	Blood group A antigen tetraose type 5 A-Tetrasaccharide
	Blood group A antigen tetraose type 5 (A-Tetrasaccharide) 是特定于A型血的四糖，具有阻止抗-A抗体与A型血物质结合的能力。该化合物可通过北极熊乳样本纯化获得。
TN1025	3,29-O-Dibenzoyloxykarounidiol	Others	Others
	3,29-O-Dibenzoyloxykarounidiol 是一种苯甲酸三萜烯酯，从 Momordica grosvenori 果实中提取。它能够抑制肿瘤启动子 TPA 诱导的 EB 病毒早期抗原活化。
T6S0033	Crotonoside 巴豆苷；异鸟苷,巴豆苷,Isoguanosine,2-HYDROXYADENOSINE	Others; FLT; HDAC	Angiogenesis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Others; Tyrosine Kinase/Adaptors
	Crotonoside (Isoguanosine) 是从中草药巴豆中分离出来的一种天然产物。它抑制 FLT3 和 HDAC3/6，有治疗急性髓性白血病 (AML)的研究潜力。
T9371	DL-Pyroglutamic acid	Others	Others
	DL-Pyroglutamic acid 对乙型肝炎表面抗原表现出强烈的灭活作用。
T41078	Lipopolysaccharides, Escherichiacoli (11C) LPS E. coli O55:B5,Lipopolysaccharide, E. coli O111:B4	Others	Others
	Lipopolysaccharides, Escherichiacoli (11C) (LPS E. coli O55:B5)是革兰阴性菌外膜的大分子成分，由脂质a、寡糖核心和o -特异性多糖(O-antigen) 3个区域组成。
TN1031	Poricoic acid B 茯苓酸B,茯苓新酸 B	Others	Others
	Poricoic acid B 是提取自 Poria cocos 中，拥有抗肿瘤作用。
TN2088	Platycodin D2 桔梗皂苷D2	IL Receptor; HBV	Immunology/Inflammation; Microbiology/Virology
	Platycodin D2 是分离自桔梗的皂苷类物质，显示除抗癌活性。
T14193	α-Galactosylceramide KRN7000,α-GalCer	Others	Others
	α-Galactosylceramide (KRN7000) 是一种具有抗肿瘤和免疫刺激作用的合成糖脂。它是一种高效的 NKT 细胞激动剂，可与 CD1d 有效结合。它与 CD1d 的复合物可与 NKT 细胞的 T 细胞抗原受体结合。
T5771	Hypocrellin A	Antibacterial; PKC; Parasite	Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology
	Hypocrellin A 是一种天然的PKC 抑制剂，具有光诱导的抗肿瘤、抗真菌和抗病毒活性，还对 MHC 限制性抗原呈递发挥免疫调节作用。
TN7075	Linocinnamarin 3-[4-(beta-D-Glucopyranosyloxy)phenyl]acrylic acid methyl ester	Phospholipase; Syk	Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
	Linocinnamarin (3-[4-(beta-D-Glucopyranosyloxy)phenyl]acrylic acid methyl ester) 是从 Fragaria ananassa Duch 中分离出来的。它对抗原刺激脱粒的抑制主要是由于 Syk/磷脂酶 Cgamma (PLCgamma) 途径的失活。
TN1661	Ganoderic acid C2 灵芝酸 C2	Reductase; Histamine Receptor; Immunology/Inflammation related	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Ganoderic acid C2 是分离自灵芝的一种三萜化合物，具有潜在的抗肿瘤生物活性，以及抗组胺、抗衰老和细胞毒性作用。它对rat lens aldose reductase 具有很高的抑制活性，IC50为 3.8 µM。
TN3416	Angelol M	Others	Others
	Angelol M shows activity in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells.
TN2417	Furomollugin 5-羟基萘并[1,2-B]呋喃-4-甲酸甲酯,呋喃大叶茜草素	Antifection	Microbiology/Virology
	Furomollugin has antiviral activity, it can strongly suppress the secretion of hepatitis B surface antigen (HBsAg), with IC50 = 2.0 micrograms/mL, in human hepatoma Hep3B cells.
TN4751	Periglaucine B	HBV	Microbiology/Virology
	Periglaucine B can inhibit hepatitis B virus (HBV) surface antigen (HBsAg) secretion in Hep G2.2.15 cells.
TN4750	Periglaucine A	HBV	Microbiology/Virology
	Periglaucine A inhibits hepatitis B virus (HBV) surface antigen (HBsAg) secretion in Hep G2.2.15 cells.
TN5878	7,2',4'-Trihydroxy-5-methoxy-3-phenylcoumarin
	7,2',4'-Trihydroxy-5-methoxy-3-arylcoumarin shows activity in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells.
TN2500	1,5,15-Tri-O-methylmorindol	Others	Others
	1,5,15-Tri-O-methylmorindol has effects against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA.
TN3309	9alpha,13alpha-Epidioxyabiet-8(14)-en-18-oic acid	Others	Others
	9alpha,13alpha-Epidioxyabiet-8(14)-en-18-oic acid shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate.
TN3699	Corchoionoside C	Antifection; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Corchoionoside C has antioxidant activity, shows strong scavenging activities on DPPH radical, it also shows weak antifungal activity. Corchoionosides A, B, and C inhibit the histamine release from rat peritoneal exudate cells induced by antigen-antibody reaction.
T79975	Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside	HBV	Microbiology/Virology
	Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside（化合物1）是一种具有抗HBV活性的木脂素类化合物。该化合物对HBV表面抗原（HBsAg）的IC50为0.58 mM，而对HBV e抗原（HBeAg）的IC50 > 2.4 mM。其可从八角茴香中提取分离。
T81813	Methyl lucidenate Q
	Methyl lucidenate Q，一种灵芝甲酯，展现了显著的抑制作用于EBV-EA诱导活性。
TN2926	3-Epicabraleahydroxylactone	Others	Others
	3-Epicabraleahydroxylactone has anti-tumor promoting effect, it has anti-carcinogenic activity by the inhibitory effect on the induction of Epstein-Barr virus early antigen(EBV-EA) by the tumor promoter.
T79976	Dihydrodehydrodiconiferyl alcohol 9-O-β-D-xylopyranoside	HBV	Microbiology/Virology
	Dihydrodehydrodiconiferyl alcohol 9-O-β-D-xylopyranoside 作为一种抗HBV剂，在Hep G2.2.15细胞系上能够抑制HBsAg和HBeAg的分泌，其IC50值分别约为1.67 mM和>2.15 mM。
T25687	Leukotriene C4 白三烯C4,LTC4,Leukotriene C
	Leukotriene C4 is the conjugation product of Leukotriene A4 and glutathione. It is the major arachidonic acid metabolite in human mast cells, macrophages, and antigen-sensitized lung tissue. It stimulates mucus secretion in the lung and produces contracti
TN4421	Latisxanthone C	Others	Others
	Latisxanthone C shows inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, it may be a valuable antitumor promoter.
TN3321	9-Methoxy-alpha-lapachone	Others	Others
	9-Methoxy-alpha-lapachone has antitumor-promoting effect, it exhibits significant inhibitory activity against 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced Epstein- Barr virus early antigen (EBV-EA) activation in Raji cells.
T14368	Azadirachtin B	Others	Others
	Azadirachtin B, a limonoid derived from the seed kernels of Azadirachta indica, exhibits a broad spectrum of biochemical activities, including insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral, and osteogenic effects. It is effective against the Epstein-Barr virus early antigen (EBV-EA), enhances alkaline phosphatase (ALP) activity, and promotes osteoblast differentiation[1][2][3].
TN5578	Abieta-8,11,13-triene-7,15,18-triol
	Abieta-8,11,13-triene-7alpha,15,18-triol,7alpha,8alpha,13beta,14beta-diepoxyabietan-18-oic acid, and 18-nor-abieta-8,11,13-triene-4alpha,7alpha,15-triol may have inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tum
T38838	QS-21 Stimulon,QS-21
	QS-21, an immunostimulatory saponin, is a powerful vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Additionally, QS-21 activates the NLRP3 inflammasome, leading to the release of cytokines IL-1β and IL-18, which are dependent on caspase-1.
T82855	Blood group A pentasaccharide A-Pentasaccharide
	A-Pentasaccharide 是一种尿液中的寡糖，具有抑制抗 A 抗体与 A 型血物质结合的功能。
TN3736	Cycloart-25-ene-3,24-diol	Others	Others
	(24R)-Cycloart-25-ene-3beta,24-diol may be an anti-tumor promoter, it exhibits inhibitory effects on both Epstein-Barr virus early antigen (EBV-EA) and (+/-)-(E)-methtyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3- hexemide (NOR 1) activation.
TN3019	4,9-Dihydroxy-alpha-lapachone	Others	Others
	4,9-Dihydroxy-alpha-lapachone has antitumor-promoting effects, it exhibits significant inhibitory activity against 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation in Raji cells. 4,9-Dihydroxy-alpha-l
TN4999	Serratenediol	BCL; PARP; Caspase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome
	Serratenediol demonstrates strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing any cytotoxicity, its effects being stronger than that of a representative control, oleanolic acid. Serratenediol can promote
TN2928	Pygenic acid A 3-Epicorosolic acid,脓毒酸A
	3-Epicorosolic acid has a potent inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induction, it has potential anti-inflammatory activities as well as cancer chemopreventive activity.3-Epicorosolic acid shows both potent α-glucosidase and pro
TN2839	2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid has anti-HIV activity. It shows an inhibitory effect on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and causes a significant delay o
T38394	PSMα3
	PSMα3 is a peptide compound that can be utilized to induce tolerance in dendritic cells (DCs) for DC vaccination strategies. It effectively penetrates and modulates human monocyte-derived DCs by modifying the maturation process induced by TLR2 or TLR4. Additionally, PSMα3 inhibits the production of both pro- and anti-inflammatory cytokines and decreases antigen uptake. Notably, PSMα3 is a significant virulence factor released by the most pathogenic strains of methicillin-resistant Staphylococcus...
T79977	Maceneolignan A
	Maceneolignan A，一种可从肉豆蔻（肉豆蔻科）假种皮分离的天然产品，有能力抑制RBL-2H3细胞内β-己糖胺酶释放，其IC50值为48.4 μM。同样，Maceneolignan A对抗原激活的RBL-2H3细胞中TNF-α释放的抑制作用，其IC50为63.7 μM。
T75567	Cabenoside D
	Cabenoside D（化合物 8）是从苔藓根的甲醇提取物中分离的一种三萜苷，显示出对12-O-十四烷酰基激素-13-乙酸酯（TPA）诱导的小鼠炎症的抗炎活性，并能抑制TPA促使的Epstein-Barr病毒（EBV）早期抗原（EBV-EA）激活。
TN4592	Murrangatin	IL Receptor; TNF; COX; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line,
T37272	9(S),12(S),13(S)-TriHOME
	9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME...
T5157	9,13-Epidioxy-8(14)-abieten-18-oic acid	Others	Others
	9,13β-Epidioxy-8(14)-abieten-18-oic acid has anti-inflammatory activities, it exhibits moderate activities on NO levels in LPS-stimulated murine microglia BV2 cells, with IC50 values of 57.3 ± 0.2 uM. It is also a potential antitumor-promoting diterpenoid, it shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate. 9 α ,13 β -Epidioxyabeit-8(14)en-18-oic acid may contribute to the growth inhibitory...
TN4277	Isocupressic acid	cAMP; P450; PKA	GPCR/G Protein; Metabolism; Tyrosine Kinase/Adaptors
	Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reproductive system, the decrease in blood flow and apoptosis of corpus luteum-derived endothelial ce
TN2511	Britannilactone diacetate 1,6-O,O-Diacetylbritannilactone	IL Receptor; PARP; ROS; MAPK; Caspase; JAK; JNK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; JAK/STAT signaling; MAPK; Proteases/Proteasome; Stem Cells
	1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound. OODBL has anti-asthmatic activity, it reduces leukotriene C4 pro
TN4140	Glochidiol	Others	Others
	Glochidiol exhibits strong inhibitory effects against all three human tumor cell lines (MCF-7, NCI-H-460 and SF-268), it exerts its antiproliferative activity through the involvement of apoptosis. It exhibits a strong inhibitory effect on mouse skin tumor
TN3607	Catalpalactone	cAMP	GPCR/G Protein
	Catalpalactone exhibits high antitermitic, and cytotoxic activities, it exhibits potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells , with IC50 values of 9.80 microM. Catalpalactone can inhibit dopamine biosynthesis by
T75566	11-Oxomogroside II A1
	11-Oxomogroside II A1（化合物 7）是一种从罗汉果乙醇提取物中分离的氧化葫芦苷，对12-O-十四烷酰基激素-13-乙酸酯（TPA）诱导的Epstein-Barr病毒（EBV）早期抗原（EBV-EA）活化具有抑制效果，并对一氧化氮（NO）供体（+/-）-(E)-甲基-2-[(E)羟基亚氨基]-5-硝基-6-甲氧基-3-己酰胺（NOR 1）的活化也展示出轻微的抑制作用。
TN2977	3-O-trans-p-Coumaroyltormentic acid	Caspase; Antifection	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	3-O-(E)-p-coumaroyl tormentic acid may be promising lead compound for developing an effective drug for treatment of leukemia, it induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition. 3-O-trans-p-coumaroyltormentic acid shows cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro, the IC50 values of 13.72, 14.29,14.61, 14.04 uM, respectively. 3beta-O-cis-p-Coumaroyltormentic acid, an...

天然产物

Blood group A antigen tetraose type 5

Cat.No: T82856

Synonym: A-Tetrasaccharide

3,29-O-Dibenzoyloxykarounidiol

Cat.No: TN1025

Target: Others

Cat.No: T6S0033

Synonym: 巴豆苷；异鸟苷,巴豆苷,Isoguanosine,2-HYDROXYADENOSINE

Target: Others, FLT, HDAC

DL-Pyroglutamic acid

Cat.No: T9371

Target: Others

Lipopolysaccharides, Escherichiacoli (11C)

Cat.No: T41078

Synonym: LPS E. coli O55:B5,Lipopolysaccharide, E. coli O111:B4

Target: Others

Poricoic acid B

Cat.No: TN1031

Synonym: 茯苓酸B,茯苓新酸 B

Target: Others

Cat.No: TN2088

Synonym: 桔梗皂苷D2

Target: IL Receptor, HBV

α-Galactosylceramide

Cat.No: T14193

Synonym: KRN7000,α-GalCer

Target: Others

Cat.No: T5771

Target: Antibacterial, PKC, Parasite

Cat.No: TN7075

Synonym: 3-[4-(beta-D-Glucopyranosyloxy)phenyl]acrylic acid methyl ester

Target: Phospholipase, Syk

Ganoderic acid C2

Cat.No: TN1661

Synonym: 灵芝酸 C2

Target: Reductase, Histamine Receptor, Immunology/Inflammation related

Cat.No: TN3416

Target: Others

Cat.No: TN2417

Synonym: 5-羟基萘并[1,2-B]呋喃-4-甲酸甲酯,呋喃大叶茜草素

Target: Antifection

Cat.No: TN4751

Target: HBV

Cat.No: TN4750

Target: HBV

7,2',4'-Trihydroxy-5-methoxy-3-phenylcoumarin

Cat.No: TN5878

1,5,15-Tri-O-methylmorindol

Cat.No: TN2500

Target: Others

9alpha,13alpha-Epidioxyabiet-8(14)-en-18-oic acid

Cat.No: TN3309

Target: Others

Corchoionoside C

Cat.No: TN3699

Target: Antifection, Histamine Receptor

Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside

Cat.No: T79975

Target: HBV

Methyl lucidenate Q

Cat.No: T81813

3-Epicabraleahydroxylactone

Cat.No: TN2926

Target: Others

Dihydrodehydrodiconiferyl alcohol 9-O-β-D-xylopyranoside

Cat.No: T79976

Target: HBV

Cat.No: T25687

Synonym: 白三烯C4,LTC4,Leukotriene C

Latisxanthone C

Cat.No: TN4421

Target: Others

9-Methoxy-alpha-lapachone

Cat.No: TN3321

Target: Others

Cat.No: T14368

Target: Others

Abieta-8,11,13-triene-7,15,18-triol

Cat.No: TN5578

Cat.No: T38838

Synonym: Stimulon,QS-21

Blood group A pentasaccharide

Cat.No: T82855

Synonym: A-Pentasaccharide

Cycloart-25-ene-3,24-diol

Cat.No: TN3736

Target: Others

4,9-Dihydroxy-alpha-lapachone

Cat.No: TN3019

Target: Others

Cat.No: TN4999

Target: BCL, PARP, Caspase

Cat.No: TN2928

Synonym: 3-Epicorosolic acid,脓毒酸A

2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid

Cat.No: TN2839

Target: HIV Protease

Cat.No: T38394

Maceneolignan A

Cat.No: T79977

Cat.No: T75567

Cat.No: TN4592

Target: IL Receptor, TNF, COX, Prostaglandin Receptor

9(S),12(S),13(S)-TriHOME

Cat.No: T37272

9,13-Epidioxy-8(14)-abieten-18-oic acid

Cat.No: T5157

Target: Others

Isocupressic acid

Cat.No: TN4277

Target: cAMP, P450, PKA

Britannilactone diacetate

Cat.No: TN2511

Synonym: 1,6-O,O-Diacetylbritannilactone

Target: IL Receptor, PARP, ROS, MAPK, Caspase, JAK, JNK, STAT

Cat.No: TN4140

Target: Others

Cat.No: TN3607

Target: cAMP

11-Oxomogroside II A1

Cat.No: T75566

3-O-trans-p-Coumaroyltormentic acid

Cat.No: TN2977

Target: Caspase, Antifection

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