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107

抑制剂 & 化合物

25

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T16378	Ogerin	Others; 5-HT Receptor; Adenosine Receptor	GPCR/G Protein; Neuroscience; Others
	Ogerin 是选择性 GPR68正向别构调节剂(pEC50:6.83)。它能够抑制小鼠对恐惧记忆的回忆。它对 A2A 受体具有适中的拮抗作用(Ki:220 nM)。对 5-HT2B 受体的拮抗作用较弱(Ki:736 nM)。
T1850	Balicatib AAE581,巴利卡替	Cysteine Protease	Proteases/Proteasome
	Balicatib (AAE581) 是组织蛋白酶K 抑制剂，其对组织蛋白酶K 的抑制作用是组织蛋白酶B、L 和S 的抑制性的10到100倍。
T12192	NCGC00229600	Others; TSH Receptor	GPCR/G Protein; Others
	NCGC00229600 是促甲状腺激素受体 (TSHR) 的变构反向激动剂。 NCGC00229600 抑制 TSH 和刺激 TSHR 的内源性激活抗体，可用于格雷夫斯病的研究。
T24706	RBC10 RBC 10,RBC-10	GTPase	GPCR/G Protein
	RBC10 抑制 Ral 与其效应物 RALBP1 的结合，以及抑制 Ral 介导的鼠胚胎成纤维细胞的细胞扩散和人类癌细胞系的非贴壁依赖性生长。
T1889	CP-640186 CP 640186	Acetyl-CoA Carboxylase	Metabolism
	CP-640186 是一种有效的乙酰辅酶 A 羧化酶 (ACC)抑制剂，抑制大鼠肝脏 ACC1 和大鼠骨骼肌 ACC2 的 IC50分别为 53 nM 和 61 nM。
T8930	CID44216842 KUC103479N-02	CDK; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	CID44216842 (KUC103479N-02) 是Cdc42选择性抑制剂。在 GDP 结合测定中，它对 Cdc42 野生型和 Cdc42Q61L 突变型的EC50分别为 0.3 和 0.5 μM。在 GTP 结合测定中，它对 Cdc42 野生型和 Cdc42Q61L 突变型的EC50分别为 1.0 和 1.2 μM。它可用作分子探针。
T1684	Nitisinone 尼替西农,NTBC,SC0735,Nitisone	Others; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; Others
	Nitisinone (SC0735) 是一种 4-羟基苯丙酮酸双加氧酶抑制剂。
T19664	ON1231320 GBO-006	Apoptosis; PLK	Apoptosis; Cell Cycle/Checkpoint
	ON1231320 (GBO-006) 是一种高度特异性的 polo 样激酶 2 抑制剂，IC50为 0.31 µM。在有丝分裂 G2/M 期阻断肿瘤细胞周期进程，它可导致细胞凋亡。它是一种芳基磺酰基吡啶并嘧啶酮，具有抗肿瘤活性。
T1496	Amiodarone hydrochloride 盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone	Potassium Channel; Adrenergic Receptor; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Amiodarone hydrochloride (Amiodarone HCl) 是一种抗心绞痛和 III 类抗心律失常药物，通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间，可导致心率和血管阻力降低。它通过成纤维细胞中的 ERK1/2和 p38 MAPK 信号传导诱导细胞增殖和肌成纤维细胞分化，可研究室上性和室性心律失常。
T3622	CP-640186 hydrochloride CP 640186 HCl,盐酸CP-640186	Acetyl-CoA Carboxylase	Metabolism
	CP-640186 hydrochloride (CP 640186 HCl) 是膜渗透性的乙酰辅酶A 羧化酶（ACC）抑制剂，抑制大鼠肝脏ACC1和大鼠骨骼肌ACC2的IC50为53 nM 和61 nM。
T3636	(E)-SIS3 SIS3,SIS3 盐酸盐,SIS3 HCl	TGF-beta/Smad	Stem Cells
	(E)-SIS3 (SIS3) 是 Smad3 的选择性抑制剂，能够抑制 Smad3 磷酸化(IC50:3 μM)。它利用 TGF-β1 抑制成纤维细胞向肌成纤维细胞分化。
T0267	Zonisamide AD 810,唑尼沙胺,CI 912	Calcium Channel; Sodium Channel; Carbonic Anhydrase	Membrane transporter/Ion channel; Metabolism
	Zonisamide (AD 810) 是锌酶碳酸酐酶 (carbonic anhydrase) 的有效抑制剂，对人类线粒体同工酶 hCA II 和 hCA V 作用的 Ki 值分别为 35.2 nM 和 20.6 nM。Zonisamide 具有抗癫痫活性，在癫痫、癫痫发作和帕金森病的研究中具有价值。
T12908	SIBA 5'-Deoxy-5'-isobutylthioadenosine,5'-Isobutylthioadenosine,5ˊ-异丁硫基-5ˊ-脱氧腺苷	Nucleoside Antimetabolite/Analog; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	SIBA (5'-Deoxy-5'-isobutylthioadenosine) 是 SAH 的合成类似物，可作为 S-腺苷甲硫氨酸介导的甲基转移的抑制剂。它干扰多种酶活性，可逆地阻断单纯疱疹病毒 1 型病毒的繁殖。
T6690	T0901317 N-(2,2,2-三氟乙基)-N-[4-[2,2,2-三氟-1-羟基-1-(三氟甲基)乙基]苯基]苯磺酰胺	Apoptosis; FXR; Liver X Receptor; ROR	Apoptosis; Metabolism
	T0901317 是一种口服有效且高度选择性的LXR 激动剂，对 LXRα 的EC50为 20 nM。它激活FXR，EC50为 5 μM。它是RORα和RORγ双重反向激动剂，Ki 值分别为 132 nM 和 51 nM。它诱导细胞凋亡，并抑制低密度脂蛋白受体缺失小鼠动脉粥样硬化的发展。
T2464	ZMC1	p53	Apoptosis
	NSC-319726 (ZMC1)是一种突变型 p53R175 再激活剂，可抑制表达 p53R175 突变的成纤维细胞的生长，IC50值为8nM。
T2437	O4I2 O-4I2,O4I2	OCT	Membrane transporter/Ion channel
	O4I2 是一种 Oct3/4诱导剂，可增强多能干细胞相关基因 Lin28、Sox2和 Nanog 的表达，并抑制 Rex1。
T32613	LCB 03-0110 dihydrochloride	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	LCB 03-0110 Dihydrochloride 是BTK 和SYK 家族以及DDR2家族中c-Src 激酶（IC50=1.3 nM）和酪氨酸激酶的有效抑制剂。在体外抑制LPS 诱导的巨噬细胞活化和TGF-β1诱导的成纤维细胞活化，抑制巨噬细胞和成纤维细胞的活化，并抑制伤口愈合模型中的瘢痕形成。
T21653	1,4-DPCA	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	1,4-DPCA 是一种脯氨酰羟化酶抑制剂，对人源包皮成纤维细胞中胶原羟基化的 IC50 为 2.4 μM，对因子抑制 HIF (FIH) 的 IC50 为 60 μM。
T36442L	(Hyp³)-Bradykinin acetate (Hyp³)-Bradykinin acetate (37642-65-2 Free base)	Bradykinin Receptor	GPCR/G Protein
	(Hyp³)-Bradykinin acetate 是一种缓激肽 B2 受体激动剂，可刺激培养的人成纤维细胞中磷酸肌醇的产生。
T4100	AS8351 NSC51355,AS-8351,AS 8351	Histone Demethylase	Chromatin/Epigenetic
	AS8351 (NSC51355) 是一种组蛋白去甲基化酶抑制剂，可以诱导人胎儿肺成纤维细胞重编程为功能性心肌细胞。
T8970	ML162	Ferroptosis; GPX; Glutathione Peroxidase	Apoptosis; Metabolism; oxidation-reduction
	ML162 是一种共价谷胱甘肽过氧化物酶 4 抑制剂。它选择性抑制表达突变 RAS 癌基因的细胞系。
T8366	Mitochonic acid 5 MA-5	Mitochondrial Metabolism	Metabolism
	Mitochonic acid 5 (MA-5) 能够调节线粒体 ATP 合成，可与线粒体结合，并改善肾小管和心肌细胞损伤。
T78170	Kras4B G12D-IN-1	Ras	GPCR/G Protein; MAPK
	Kras4B G12D-IN-1为Kras4B G12D的抑制剂，表现出抗癌活性。在降低Kras4B G12D表达的小鼠胚胎成纤维细胞(MEF)中减少Kras蛋白水平。
T2019	OAC2	OCT	Membrane transporter/Ion channel
	OAC2 是一种 Oct4 激活剂，通过 Oct4 基因启动子激活表达，通过提高胚胎成纤维细胞诱导多能干细胞的产生速率来提高重编程效率，是 OAC1 的类似物。
T3031	A 83-01 ALK5 Inhibitor IV,A8301	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	A 83-01 (ALK5 Inhibitor IV) 是一种 TGF-βI 型受体 ALK5、ALK4 和 ALK7 的抑制剂 (IC50=12/45/7.5 nM)。A 83-01 可促进小鼠成纤维细胞重编程为 iPSCs。A 83-01 可用于类器官培养。
T16342	KL1333 NQO1 activator 1	NADPH; Mitochondrial Metabolism	Metabolism
	KL1333 (NQO1 activator 1) 是口服NAD+调节剂，与 NAD(P)H: 醌氧化还原酶 1 作为底物反应。它改善线粒体脑肌病、乳酸酸中毒和中风样发作成纤维细胞的能量代谢和线粒体功能障碍。它对顺铂诱导的小鼠耳蜗培养耳毒性的保护作用。
TP1904L	FSLLRY-NH2 TFA(245329-02-6 free base)	Protease-activated Receptor	GPCR/G Protein
	FSLLRY-NH2 TFA(245329-02-6 free base) 是一种蛋白酶激活受体 2 (PAR2) 抑制剂。在 ICR 小鼠中逆转紫杉醇诱导的机械异常性疼痛、热痛觉过敏和 PKC 激活。阻断分离的心脏成纤维细胞中的 ERK 活化和胶原蛋白生成。还可以减轻皮肤癣菌相关瘙痒小鼠模型的症状。
T38293	4-CPPC	Others	Others
	4-CPPC 是一种巨噬细胞迁移抑制因子 2 (MIF-2; IC50= 27 μM) 的抑制剂。它对 MIF-2 的选择性高于 MIF-1 (IC50= 450 μM)。当以 10 μM 浓度使用时，它在体外抑制 MIF-2，但不抑制 MIF-1，与 CD74 结合。 4-CPPC（5、10 和 25 μM）抑制原代人皮肤成纤维细胞中 MIF-2 诱导的 ERK1/2 磷酸化。
T10409	ATX inhibitor 5	PDE	Metabolism
	ATX inhibitor 5 是一种有效且具有口服活性的 autotaxin (ATX) 抑制剂（IC50 ： 15.3 nM），可降低 CCl4 诱导的肝纤维化水平，具有抗肝纤维化作用，。
T24714	RKN5755 RKN-5755,RKN 5755
	RKN5755 is a selective activated fibroblasts inhibitor that acts by inhibiting the enhanced migration of fibroblasts cocultured with cancer cells by binding to β-arrestin1 and interfering with β-arrestin1-mediated cofilin signaling pathways.
T69502	HSP47 inhibitor III
	HSP47 inhibitor III suppressed collagen type I expression in human and mouse cells and suppressed the viability and migration of lung fibroblasts.
TP2341	Hexapeptide-11 Peptamide 6,Fvapfp,Phe-val-ala-pro-phe-pro
	Hexapeptide-11 is a novel proteostasis network modulator in human diploid fibroblasts.
T36308	PF-06843195
	PF-06843195 is a highly selective PI3Kα inhibitor with an IC50 of 18 nM in Rat1 fibroblasts. The Kis of PF-06843195 for PI3Kα and PI3Kδ in biochemical kinase assay are less than 0.018 nM and 0.28 nM, respectively. PF-06843195 has great suppression of the PI3K/mTOR signaling pathway and durable antitumor efficacy[1]. PF-06843195 inhibits the breast cancer cell lines MCF7 and T47D proliferation with IC50s of 62 nM and 32 nM, respectively[1].PF-06843195 inhibits pAKT (T308) in MCF7 and T47D cells w...
T12923	(Rac)-SIS3 free base	TGF-beta/Smad	Stem Cells
	SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.
T25055	alpha-RA-F α RA F,alphaRAF,α-RA-F,αRAF
	alpha-RA-F can modulate collagen synthesis and matrix metalloproteinases (MMPs) expression levels by boosting collagen synthesis and reducing MMPs expression levels in human fibroblasts without cytotoxicity.
T30662	C.I. 74240 NSC 324570,NSC-324570,NSC324570
	C.I. 74240 is a copper-containing dye used as a gelling agent for lubricants, for staining of bacteria and for the dyeing of histiocytes and fibroblasts in vivo.
T29840	Alcian blue
	Alcian blue is a copper-containing dye used as a gelling agent for lubricants, for staining of bacteria and for the dyeing of histiocytes and fibroblasts in vivo.
T22490	2,3-DCPE hydrochloride	Others	Others
	Induces p21 expression and S-phase arrest in cancer cells via ERK-mediated pathways. IC50 values are 0.89 and 12.6 μM for LoVo human colon cancer cell line and normal human fibroblasts respectively.
T30111	AR 12465 AR-12465
	AR 12465 is a trapidil derivative which may affect LDL receptor mediated uptake and degradation of 125 I-LDL by human skin fibroblasts (HSF) and human hepatic cells (HEP G2).
T38489	D,L-erythro-PDMP
	D,L-erythro-PDMP, an erythro isomer of PDMP, exhibits growth inhibition on cultured rabbit skin fibroblasts. Additionally, this compound serves as an effective inhibitor of UDP-glucose: ceramide glucosyltransferase.
T30676	C012 Dihydrochloride C-012 Dihydrochloride,C 012 Dihydrochloride,C 012 2HCl,C012 2HCl,C-012 2HCl
	C012 Dihydrochloride is a novel small molecule compound that sensitized BRAF wild-type melanoma cells to verofenib. It can significantly reduce the activity of melanoma cells and has limited toxicity to normal human fibroblasts.
T33764	NVS-SM2
	NVS-SM2 is an effective small molecule splicing enhancer of SMN2 with oral activity. NVS-SM2 showed increased exon 7 inclusion and upregulated SMN protein expression in SMA fibroblasts and SMN cells Δ7 5025 mouse myoblasts.
T36496	Conglobatin C1 Conglobatin C1
	Conglobatin C1 is a bacterial metabolite that has been found inStreptomycesMST-91080 and has anticancer activity.1It is cytotoxic to NS-1 mouse myeloma cells (IC50= 1.05 μg/ml) but not NFF human fibroblasts (IC50= >100 μg/ml). 1.Lacey, H.J., Booth, T.J., Vuong, D., et al.Conglobatins B-E: Cytotoxic analogues of the C2-symmetric macrodiolide conglobatinJ. Antibiot. (Tokyo)73(11)756-765(2020)
T36495	Conglobatin B
	Conglobatin B is a bacterial metabolite that has been found inStreptomycesMST-91080 and has anticancer activity.1It is cytotoxic to NS-1 mouse myeloma cells (IC50= 0.084 μg/ml) but not NFF human fibroblasts (IC50= >100 μg/ml). 1.Lacey, H.J., Booth, T.J., Vuong, D., et al.Conglobatins B-E: Cytotoxic analogues of the C2-symmetric macrodiolide conglobatinJ. Antibiot. (Tokyo)73(11)756-765(2020)
T36884	BM-1244
	BM-1244 is a potent Bcl-xL/Bcl-2 inhibitor with Kis of 134 and 450 nM for Bcl- xL and Bcl-2, respectively. BM-1244 inhibits senescent fibroblasts (SnCs) with an EC50 of 5 nM[1].
TP2186	PalMitoyl Tripeptide-1	Others	Others
	PalMitoyl Tripeptide-1 对人体皮肤成纤维细胞中胶原蛋白、纤连蛋白和透明质酸的合成有影响，可用于制备抗衰老化妆品。
T35670	Miro1 Reducer
	Promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC50 = 7.8 μM). Exhibits no significant effect on related outer mitochondrial membrane protein Mitofusin. Reduces stress-induced degeneration of dopaminergic neurons derived from PD patient iPSCs. Rescues age-dependent neuronal loss and prolongs lifespan in fly PD models.
T37440	C2 Adamantanyl Galactosylceramide (d18:1/2:0)
	C2 Adamantanyl Galactosylceramide (d18:1/2:0) (AdaGalCer) is a bioactive sphingolipid. It reduces globotriaosylceramide 3 synthesis from exogenous lactosylceramide in microsomes. AdaGalCer stimulates recombinant glucocerebrosidase activity in a pH-dependent manner. It activates glucocerebrosidase to decrease glucosylceramide accumulation in fibroblasts and lymphoblasts isolated from patients with Gaucher and Fabry disease, respectively.
T36073	S-Acetyl-L-glutathione
	S-Acetyl-L-glutathione is a derivative of glutathione .1 It increases intracellular GSH levels in primary fibroblasts derived from patients with glutathione synthetase deficiency when used at a concentration of 50 μM. S-Acetyl-L-glutathione (5 mM) induces apoptosis in Daudi, Raji, and Jurkat lymphoma cells.2 It inhibits the replication of herpes simplex virus 1 (HSV-1) in human foreskin fibroblasts when used at concentrations of 5 and 10 mM.3 S-Acetyl-L-glutathione (6.25 μg/g per day) increases ...
T37853	Cholesteryl Lignocerate
	Cholesteryl lignocerate is a cholesterol ester that has been found in human meibum. Cholesteryl lignocerate can be hydrolyzed by cellular extracts from cultured human skin fibroblasts isolated from healthy individuals but not patients with cholesteryl ester storage disease (CESD) or Wolman disease.

化合物

Cat.No: T16378

Target: Others, 5-HT Receptor, Adenosine Receptor

Cat.No: T1850

Synonym: AAE581,巴利卡替

Target: Cysteine Protease

Cat.No: T12192

Target: Others, TSH Receptor

Cat.No: T24706

Synonym: RBC 10,RBC-10

Target: GTPase

Cat.No: T1889

Synonym: CP 640186

Target: Acetyl-CoA Carboxylase

Cat.No: T8930

Synonym: KUC103479N-02

Target: CDK, Ras

Cat.No: T1684

Synonym: 尼替西农,NTBC,SC0735,Nitisone

Target: Others, Reactive Oxygen Species

Cat.No: T19664

Synonym: GBO-006

Target: Apoptosis, PLK

Amiodarone hydrochloride

Cat.No: T1496

Synonym: 盐酸胺碘酮,Amiodar,Amiodarone HCl,Nexterone

Target: Potassium Channel, Adrenergic Receptor, Autophagy

CP-640186 hydrochloride

Cat.No: T3622

Synonym: CP 640186 HCl,盐酸CP-640186

Target: Acetyl-CoA Carboxylase

Cat.No: T3636

Synonym: SIS3,SIS3 盐酸盐,SIS3 HCl

Target: TGF-beta/Smad

Cat.No: T0267

Synonym: AD 810,唑尼沙胺,CI 912

Target: Calcium Channel, Sodium Channel, Carbonic Anhydrase

Cat.No: T12908

Synonym: 5'-Deoxy-5'-isobutylthioadenosine,5'-Isobutylthioadenosine,5ˊ-异丁硫基-5ˊ-脱氧腺苷

Target: Nucleoside Antimetabolite/Analog, HSV

Cat.No: T6690

Synonym: N-(2,2,2-三氟乙基)-N-[4-[2,2,2-三氟-1-羟基-1-(三氟甲基)乙基]苯基]苯磺酰胺

Target: Apoptosis, FXR, Liver X Receptor, ROR

Cat.No: T2464

Target: p53

Cat.No: T2437

Synonym: O-4I2,O4I2

Target: OCT

LCB 03-0110 dihydrochloride

Cat.No: T32613

Target: Src

Cat.No: T21653

Target: HIF/HIF Prolyl-Hydroxylase

(Hyp³)-Bradykinin acetate

Cat.No: T36442L

Synonym: (Hyp³)-Bradykinin acetate (37642-65-2 Free base)

Target: Bradykinin Receptor

Cat.No: T4100

Synonym: NSC51355,AS-8351,AS 8351

Target: Histone Demethylase

Cat.No: T8970

Target: Ferroptosis, GPX, Glutathione Peroxidase

Mitochonic acid 5

Cat.No: T8366

Synonym: MA-5

Target: Mitochondrial Metabolism

Kras4B G12D-IN-1

Cat.No: T78170

Target: Ras

Cat.No: T2019

Target: OCT

Cat.No: T3031

Synonym: ALK5 Inhibitor IV,A8301

Target: ALK, TGF-beta/Smad

Cat.No: T16342

Synonym: NQO1 activator 1

Target: NADPH, Mitochondrial Metabolism

FSLLRY-NH2 TFA(245329-02-6 free base)

Cat.No: TP1904L

Target: Protease-activated Receptor

Cat.No: T38293

Target: Others

ATX inhibitor 5

Cat.No: T10409

Target: PDE

Cat.No: T24714

Synonym: RKN-5755,RKN 5755

HSP47 inhibitor III

Cat.No: T69502

Cat.No: TP2341

Synonym: Peptamide 6,Fvapfp,Phe-val-ala-pro-phe-pro

Cat.No: T36308

(Rac)-SIS3 free base

Cat.No: T12923

Target: TGF-beta/Smad

Cat.No: T25055

Synonym: α RA F,alphaRAF,α-RA-F,αRAF

Cat.No: T30662

Synonym: NSC 324570,NSC-324570,NSC324570

Cat.No: T29840

2,3-DCPE hydrochloride

Cat.No: T22490

Target: Others

Cat.No: T30111

Synonym: AR-12465

D,L-erythro-PDMP

Cat.No: T38489

C012 Dihydrochloride

Cat.No: T30676

Synonym: C-012 Dihydrochloride,C 012 Dihydrochloride,C 012 2HCl,C012 2HCl,C-012 2HCl

Cat.No: T33764

Cat.No: T36496

Synonym: Conglobatin C1

Cat.No: T36495

Cat.No: T36884

PalMitoyl Tripeptide-1

Cat.No: TP2186

Target: Others

Cat.No: T35670

C2 Adamantanyl Galactosylceramide (d18:1/2:0)

Cat.No: T37440

S-Acetyl-L-glutathione

Cat.No: T36073

Cholesteryl Lignocerate

Cat.No: T37853

Cat. No.	Product Name	Target	Signaling Pathways
T3881	Vaccarin	Integrin; Akt; PERK; AMPK	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Vaccarin 是从王不留行中提取的一种黄酮糖苷，可显著促进伤口愈合以及伤口部位的内皮和成纤维细胞增殖。它通过激活 AMPK 信号通路改善胰岛素抵抗和脂肪变性。
T6S0923	Hypericin Hypericine,金丝桃素,Cyclosan	Apoptosis; Antiviral; Influenza Virus; Tyrosine Kinases; Antibacterial; PKC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Hypericin (Cyclosan) 是贯叶连翘的提取物，有抗菌、抗病毒、抗肿瘤和抗抑郁作用。
T4454	Traumatic Acid Dodec-2-Enedioic Acid,2E-Dodecenedioic Acid,愈伤酸,Trans-2-Dodecenedioic Acid	Antioxidant	oxidation-reduction
	Traumatic Acid (Dodec-2-Enedioic Acid) 是一种单不饱和二元羧酸，从菜豆中分离得到。它可减少膜磷脂的过氧化，并表现出抗氧化和对胶原生物合成的刺激作用。它可用于许多与胶原蛋白生物合成障碍和氧化应激有关的皮肤疾病的研究。
T4004	Concanavalin A	Apoptosis	Apoptosis
	Concanavalin A 是 Ca2+/Mn2+依赖性和甘露糖/葡萄糖结合植物凝集素。它能够促使程序性细胞死亡。
T4923	7-Dehydrocholesterol Provitamin D3,7-DHC,7-去氢胆固醇	Endogenous Metabolite	Metabolism
	7-Dehydrocholesterol (Provitamin D3) 是合成胆固醇和维生素 D3的前体。7-Dehydrocholesterol 下调培养的 Smith-Lemi-Opitz 综合征皮肤成纤维细胞中的胆固醇生物合成。
TMA2394	DL-alpha-Tocopherol DL-α-生育酚,消旋-α-生育酚,DL-α-Tocopherol,Alpha-Tochopherol,Ephanyl	Antioxidant; Ferroptosis	Apoptosis; oxidation-reduction
	DL-alpha-Tocopherol (Ephanyl) 是一种合成维生素 E，能保护皮肤成纤维细胞免受紫外线的细胞毒性作用，具有抗氧化作用。
TN7117	regaloside I	Others	Others
	Regaloside I 是百合中的单体成分,可能是保护人类皮肤成纤维细胞免受 UVA 诱导的形态变化的主要成分。
T5295	1-Hydroxyoctadecane 硬脂醇,1-Octadecanol,Stearyl alcohol,Octadecanol	Others; Endogenous Metabolite	Metabolism; Others
	1-Hydroxyoctadecane (OctadecanolOctadecanol) 是内源性代谢产物的一种。
T3768	Epifriedelanol 表木栓醇,Epifriedelinol	Others	Others
	Epifriedelanol (Epifriedelinol) 是一种分离自 Ulmus davidiana 根皮中的三萜类化合物，具有抗肿瘤作用，可以减缓人原始细胞的衰老。
T4S0553	Theaflavin-3'-Gallate 茶黄素-3-没食子酸酯,Theaflavin 2B,THEAFLAVIN 3'-O-GALLATE,茶黄素-3'-没食子酸酯	Others	Others
	Theaflavin-3'-Gallate (Theaflavin 2B) 是红茶茶黄素单体，是红茶生物学上重要的活性成分，对健康有益。它以时间和浓度依赖性方式与还原型谷胱甘肽直接反应。它充当促氧化剂并在癌细胞中诱导氧化应激。
T5120	Rhamnose 6-Deoxyhexopyranose,L-鼠李糖,6-Deoxy-L-mannose,alpha-L-Rhamnose	Calcium Channel; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism
	alpha-L-Rhamnose (6-Deoxy-L-mannose) 是存在植物和细菌中的一种单糖。Rhamnose- 免疫原连接物能被用于免疫疗法。Rhamnose 能通过胞外途径穿过上皮细胞，能够作为肠吸收的标志。
T3763	Fumaric acid Lichenic acid,Fumarate,2-Butenedioic acid,Trans-Butenedioic acid,反丁烯二酸,Donitic acid,Allomaleic acid,富马酸	Endogenous Metabolite	Metabolism
	Fumaric acid (2-Butenedioic acid) 与烟酸酶缺乏症相关，是癌症相关的内源性代谢物。
T3051	Theaflavin-3-gallate 茶黄素-3-没食子酸酯,茶黄素 3-没食子酸酯,茶黄素 -3-没食子酸,Theaflavine-3-Gallate	Others	Others
	Theaflavin-3-gallate (Theaflavine-3-Gallate) 是红茶茶黄素单体，是红茶生物学上重要的活性成分，对健康有益。它以时间和浓度依赖性方式与还原型谷胱甘肽直接反应。它充当促氧化剂并在癌细胞中诱导氧化应激。
T5279	Ethylmalonic acid alpha-Carboxybutyrate,2-Ethylmalonic acid,乙基丙二酸	Others; Endogenous Metabolite	Metabolism; Others
	Ethylmalonic acid (alpha-Carboxybutyrate) 是潜在有毒物质，非致癌性，与神经性厌食和甲氧基脱羧酶缺乏症有关。
T2S2043	Dracorhodin perchlorate Dracorhodin perochlorate,血竭素高氯酸盐,Dracohodin perochlorate	Apoptosis; Others	Apoptosis; Others
	Dracorhodin perchlorate 是来源于中药血竭的一种天然产物。它抑制细胞生长，并以剂量和时间依赖性方式诱导成纤维细胞凋亡，将细胞周期阻滞在 G1 期，可作为抗乳腺癌的候选药物。
T4430	Isosaponarin	Others	Others
	Isosaponarin increases collagen synthesis in human fibroblasts, causes by up-regulated TbetaR-II and P4H production.
TN6495	3,4-O-dimethylcedrusin
	3′,4-O-Dimethylcedrusin can improve wound healing in vivo by stimulating the formation of fibroblasts and collagen.
T82453	Epothilone D1
	Epothilone D1为分离得到的天然产物，展现对小鼠成纤维细胞的细胞毒性。
TN2177	Sanggenol L	c-Myc; NF-κB	Cell Cycle/Checkpoint; NF-κB
	Sanggenol L shows higher cytotoxicity against human oral tumor cell lines (HSC-2 and HSG) than against normal human gingival fibroblasts (HGF), it induces apoptosis via caspase activation and inhibition of NF-κB/IκBα± phosphorylation as a potent chemother
T36337	Burnettramic Acid A aglycone
	Burnettramic acid A aglycone is a fungal metabolite and an aglycone form of burnettramic acid A originally isolated fromA. burnettiithat has anticancer activity.1It is cytotoxic to NS-1 murine myeloma cells but not neonatal foreskin fibroblasts (IC50s = 8.4 and >100 μg/ml, respectively). 1.Li, H., Gilchrist, C.L.M., Lacey, H.J., et al.Discovery and heterologous biosynthesis of the burnettramic acids: Rare PKS-NRPS-derived bolaamphiphilic pyrrolizidinediones from an Australian fungus, Aspergillus...
T79989	Funiculosin	Antibiotic	Microbiology/Virology
	Funiculosin为一种中性亲脂性抗生素，能够抑制DNA及RNA病毒，并具备抗真菌活性。在初级鸡胚成纤维细胞中，Funiculosin可有效抑制致病真菌引发的感染。
TMA1743	Ergosterol peroxide	ERK; VEGFR; p38 MAPK; Wnt/beta-catenin; Akt; JAK; CDK; JNK; STAT; Antifection	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pro-apoptotic protein Puma and Bax to
T38243	Hygrolidin
	Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus. It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC50s = 2.9, 5.2, and 33 ng/ml, respectively). Hygrolidin induces the expression and levels of p21 in DLD-1 cells, but not WI-38 fibroblasts, and leads to cell accumulation in the G1 and S phases without inducing apoptosis. It has antiparasitic activity against T. cruzi, L. donovan...
T36954	Nemorosone
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...
TN3616	Cedrelone	Apoptosis; MMP; Antifection	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Cedrelone 是一种柠檬苦素类化合物，是一种吩嗪生物合成样结构域蛋白 (PBLD) 激活剂。Cedrelone 可诱导癌细胞凋亡 (apoptosis)。Cedrelone 是一种非常有效的细胞凋亡诱导剂，它能导致细胞周期停止。Cedrelone 具有杀虫活性，可抑制 P. saucia 的箭毒生长，并可抑制乳草蝽（Oncopeltus fasciatus）的蜕皮。Cedrelone具有抗肿瘤作用，对SMMC-7721、A-549、MCF-7 和 SW480 等癌细胞株具有显著的细胞毒性。

天然产物

Cat.No: T3881

Target: Integrin, Akt, PERK, AMPK

Cat.No: T6S0923

Synonym: Hypericine,金丝桃素,Cyclosan

Target: Apoptosis, Antiviral, Influenza Virus, Tyrosine Kinases, Antibacterial, PKC

Cat.No: T4454

Synonym: Dodec-2-Enedioic Acid,2E-Dodecenedioic Acid,愈伤酸,Trans-2-Dodecenedioic Acid

Target: Antioxidant

Cat.No: T4004

Target: Apoptosis

7-Dehydrocholesterol

Cat.No: T4923

Synonym: Provitamin D3,7-DHC,7-去氢胆固醇

Target: Endogenous Metabolite

DL-alpha-Tocopherol

Cat.No: TMA2394

Synonym: DL-α-生育酚,消旋-α-生育酚,DL-α-Tocopherol,Alpha-Tochopherol,Ephanyl

Target: Antioxidant, Ferroptosis

Cat.No: TN7117

Target: Others

1-Hydroxyoctadecane

Cat.No: T5295

Synonym: 硬脂醇,1-Octadecanol,Stearyl alcohol,Octadecanol

Target: Others, Endogenous Metabolite

Cat.No: T3768

Synonym: 表木栓醇,Epifriedelinol

Target: Others

Theaflavin-3'-Gallate

Cat.No: T4S0553

Synonym: 茶黄素-3-没食子酸酯,Theaflavin 2B,THEAFLAVIN 3'-O-GALLATE,茶黄素-3'-没食子酸酯

Target: Others

Cat.No: T5120

Synonym: 6-Deoxyhexopyranose,L-鼠李糖,6-Deoxy-L-mannose,alpha-L-Rhamnose

Target: Calcium Channel, Endogenous Metabolite

Cat.No: T3763

Synonym: Lichenic acid,Fumarate,2-Butenedioic acid,Trans-Butenedioic acid,反丁烯二酸,Donitic acid,Allomaleic acid,富马酸

Target: Endogenous Metabolite

Theaflavin-3-gallate

Cat.No: T3051

Synonym: 茶黄素-3-没食子酸酯,茶黄素 3-没食子酸酯,茶黄素 -3-没食子酸,Theaflavine-3-Gallate

Target: Others

Ethylmalonic acid

Cat.No: T5279

Synonym: alpha-Carboxybutyrate,2-Ethylmalonic acid,乙基丙二酸

Target: Others, Endogenous Metabolite

Dracorhodin perchlorate

Cat.No: T2S2043

Synonym: Dracorhodin perochlorate,血竭素高氯酸盐,Dracohodin perochlorate

Target: Apoptosis, Others

Cat.No: T4430

Target: Others

3,4-O-dimethylcedrusin

Cat.No: TN6495

Cat.No: T82453

Cat.No: TN2177

Target: c-Myc, NF-κB

Burnettramic Acid A aglycone

Cat.No: T36337

Cat.No: T79989

Target: Antibiotic

Ergosterol peroxide

Cat.No: TMA1743

Target: ERK, VEGFR, p38 MAPK, Wnt/beta-catenin, Akt, JAK, CDK, JNK, STAT, Antifection

Cat.No: T38243

Cat.No: T36954

Cat.No: TN3616

Target: Apoptosis, MMP, Antifection

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