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230

抑制剂 & 化合物

28

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T23757	Ascorbic acid, rutoside drug combination Rutinoscorbin,Rutascorbin,Ruta C 60,Cerutin
	Ascorbic acid, rutoside drug combination is used for treating diabetic retinopathy.
T12829	Salmeterol 沙美特罗,GR33343X	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Salmeterol (GR33343X) 是一种选择性的人β2肾上腺素受体激动剂。它能够有效刺激 cAMP 积累，作用于 CHO 细胞，对人β2，β1和β3肾上腺素受体的 pEC50分别为 9.6、6.1 和 5.9。
T7614	Eniluracil GW776C85,5-Ethynyluracil	Others	Others
	Eniluracil (GW776C85) 是不可逆的二氢嘧啶脱氢酶(DPD)抑制剂，是一种尿嘧啶类似物，能够使 5-FU 的口服生物利用度提高到 100%，促进均匀吸收和可预测的毒性。
T3661	Citarinostat ACY241,HDAC-IN-2	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Citarinostat (ACY241) 是一种强效、选择性和口服组蛋白脱乙酰酶 (HDAC) 抑制剂，具有抗肿瘤活性，对 HDAC1、HDAC2、HDAC3、HDAC6 和 HDAC8 的 IC50分别为 35、45、46、2.6 和 137 nM。
T7744	Piperaquine tetraphosphate tetrahydrate 4,4'-(1,3-丙烷双-4,1-哌嗪基)双(7-氯喹啉)磷酸盐水合物,四磷酸哌喹四水合物	Parasite	Microbiology/Virology
	Piperaquine tetraphosphate tetrahydrate 是一种双喹啉抗寄生虫剂，可与青蒿素联用研究抗疟。
T6653	Salmeterol Xinafoate Salmetedur,昔美酸沙美特罗,沙美特罗昔萘酸酯,GR 33343X xinafoate,Arial	HIV Protease; Adrenergic Receptor	GPCR/G Protein; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Salmeterol Xinafoate (GR 33343X xinafoate) 是选择性人β2肾上腺素受体激动剂。Salmeterol 有效刺激 cAMP 积累，能够作用于 CHO 细胞，对人β2，β1和β3肾上腺素受体的 pEC50分别为 9.6、6.1 和 5.9。
T7532	Piperaquine	Parasite	Microbiology/Virology
	Piperaquine 是一种双喹啉化合物，可抑制来自疟疾感染患者的恶性疟原虫分离株的离体生长，IC50 范围为 11.8-217.3 nM。
T3266	Lumefantrine Benflumetol,dl-Benflumelol,苯芴醇	Others; Parasite; Autophagy	Autophagy; Microbiology/Virology; Others
	Lumefantrine (dl-Benflumelol) 是一种抗疟药，用于治疗急性单纯性疟疾。与Artemether 联用，可提高疗效。
T2554	Etofibrate	Others	Others
	Etofibrate 是烟酸和氯贝酸的醚二醇-1,2 二酯。它是动物和人类中一种有效的降血脂剂。
T63166L	(S, R)-LSN 3318839 (S, R)-LSN 3318839(Isomer-2764704-18-7)	Glucagon Receptor	GPCR/G Protein

T7537	Norgestimate 炔诺肟酯,诺孕酯	Progesterone Receptor	Others
	Norgestimate 是一种具有口服活性、高度选择性的孕激素活性和较小雄激素作用的孕激素，是一种合成的孕激素类似物。它可用作口服的避孕药。
T1430	Betamipron CS-443,N-Benzoyl-β-alanine,倍他米隆	Antibacterial; Antibiotic	Microbiology/Virology
	Betamipron (CS-443) 与Panipenem 联用，可抑制Panipenem 摄取进入肾小管，防止肾毒性。
T2239L	Raltegravir 雷特格韦,MK-0518	HIV Protease; Integrase	Microbiology/Virology; Proteases/Proteasome
	Raltegravir (MK-0518) 是一种HIV 整合酶抑制剂。
T27787L	L-797,591 hydrochloride L-797,591 hydrochloride(217480-24-5 Free base)
	L-797,591 hydrochloride 对生长抑素受体亚型 1 (SSTR1)有活性。L-797,591 hydrochloride 常与 AG1478 联合使用来增强表达 SSTR1的细胞中 p-ERK5的表达。L-797,591 hydrochloride 在共转染的细胞中显著增强了 p38的磷酸化，这一作用在与 AG1478联合处理时被逆转。
T65232	HEDTA N-(2-Hydroxyethyl)ethylenediaminetriacetic acid	Others	Others
	HEDTA 是一种螯合剂，常与柠檬酸联合用药来研究血液疾病和脑部血液应激。
T14408	Azido-PEG1-CH2CO2H 4-哌啶酮缩乙二醇	Others; PROTAC Linker	Others; PROTAC
	Azido-PEG1-CH2CO2H 是属于 alkyl/ether 类的PROTAC linker，可用于合成 PROTAC BRD4 Degrader-1.
T7045	Clonidine Nexiclon,Catapres,Kapvay,可乐定	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Clonidine (Kapvay) 是 alpha2 肾上腺素能激动剂。
T3139	Sultamicillin Tosylate Bacimex,舒巴西林,舒他西林甲苯磺酸盐,Unacim orale	Antibacterial; Antibiotic	Microbiology/Virology
	Sultamicillin Tosylate (Unacim orale) 是一种口服活性 β-内酰胺酶抑制剂，具有抗菌活性。它是舒巴坦与氨苄西林的双酯的甲苯磺酸盐。
T76877	Vofatamab RG-7444,B-701,MFGR-1877S	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Vofatamab (B-701) 是一种全人源靶向 FGFR3 的单克隆抗体。Vofatamab 具有潜在的抗癌抗肿瘤活性，常与其他化合物联用来治疗癌症。
T0996	Ethynodiol diacetate Ethynodiol acetate,双醋炔诺醇,8080 CB	Estrogen/progestogen Receptor; Progesterone Receptor	Endocrinology/Hormones; Others
	Ethynodiol diacetate (Ethynodiol acetate) 是一种可用作激素避孕药的甾体孕激素，具有相对较少或没有雄激素效果，而具有显著雌激素作用。
T12632L	(S)-Mirtazapine (S)-6-Azamianserin,(S)-Org3770	5-HT Receptor	GPCR/G Protein; Neuroscience
	(S)-Mirtazapine ((S)-Org3770) 是 Mirtazapine 的 S(+)-对映体。(S)-Mirtazapine 是一种选择性 5-HT2 受体拮抗剂,具有促痛觉作用,常与Mirtazapine 的 R(-)-对映体混合使用来研究抑郁症。
T67964	Terflavoxate	Microtubule Associated	Cytoskeletal Signaling
	Terflavoxate 是一种新型的、具有口服活性的半合成的他汀类微管抑制剂，常与卡培他滨一起联合使用。Terflavoxate 用于癌症的研究。
T4506	Gadopentetate dimeglumine Meglumine gadopentetate,SH-L-451A,Gd-DTPA,Gadopentetic acid dimeglumine,钆喷酸葡胺,Gadopentetic acid dimeglumine salt	Others	Others
	Gadopentetate dimeglumine (Gd-DTPA) 可用于核磁共振成像 (MRI) 中，使血管、器官和其他非骨组织能够更清晰地被看到。
T0100	Atazanavir sulfate 阿扎那韦硫酸盐,BMS-232632,BMS-232632 sulfate,硫酸阿扎那韦	P450; SARS-CoV; HIV Protease; P-gp	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Atazanavir sulfate (BMS-232632 sulfate) 是一种氮杂肽和 HIV 蛋白酶抑制剂，与其他抗 HIV 药物联合用于治疗 HIV 感染和艾滋病。它也是SARS-CoV 3CLpro 抑制剂，IC50为 3.49 μM。
T40598	Norethindrone acetate 19-Norethindroneacetate	Estrogen Receptor/ERR; Progesterone Receptor	Endocrinology/Hormones; Others
	Norethindrone acetate (19-Norethindroneacetate) 是一种雌性激素，对青少年月经和肝腺瘤有抑制作用，常与孕激素联合使用，可用于研究子宫内膜异位症。
T19080	DOPE 1,2-二油酰-SN-甘油-3-磷酰乙醇胺	Others	Others
	DOPE (DOPE) 是一种阳离子脂质体的中性辅助脂质 (helper lipid)，能够与阳离子磷脂结合，增强裸 siRNA 的转染效率。
T2204	Diaveridine 二氨藜芦啶,EGIS-5645,敌菌净,CCRIS-3784,AI3-23935	DHFR; Antifolate; Antibacterial	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Diaveridine (AI3-23935) 是二氢叶酸还原酶的抑制剂，对于野生型 DHFR 的Ki 值为 11.5 nM。它也是一种抗菌剂。
T21432	Molindone (±)-Molindone,Moban,Molindonum,SPN-810M	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Molindone ((±)-Molindone) 是一种治疗性抗精神病药物，通过阻断大脑中多巴胺的作用而用于治疗精神分裂症。Molindone 常与羟色胺联合使用，以剂量依赖性方式增加错误并降低反应率。
T1119	Rasagiline 雷沙吉兰,AGN1135,TVP1012	BCL; MAO; Monoamine Oxidase	Apoptosis; Metabolism; Neuroscience
	Rasagiline (AGN1135) 是不可逆的、高效的、选择性的线粒体单胺氧化酶 (MAO) 抑制剂，抑制大鼠脑 MAO B 和 MAO A 的 IC50分别为 4.43 nM 和 412 nM。
T9585	GNE-9815 3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide	Raf	MAPK
	GNE-9815 (3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide) 是一种高激酶选择性 RAF 抑制剂，可用于通过联合治疗靶向 KRAS 突变癌症。
T60009	YS-370	P-gp	Membrane transporter/Ion channel; Neuroscience
	YS-370 是一种具有口服活性的 P-gp 抑制剂，对 CYP3A4 有中度抑制作用。 YS-370 有效逆转对紫杉醇和秋水仙碱的多药耐药性，与紫杉醇联合应用表现出更强的抗肿瘤活性。
T3335	Darunavir Ethanolate 地瑞那韦乙醇盐,UIC 94017,Darunavir Ethanolate,TMC114,达芦那韦乙醇	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Darunavir Ethanolate (UIC 94017) 是一种HIV 蛋白酶抑制剂，可以用于 HIV/AIDS 的相关研究。对野生型 HIV-1 蛋白酶的Ki 值为1 nM。
T3658	Trifluridine/tipiracil hydrochloride mixture Trifluridine-tipiracil hydrochloride mixture,TAS102,TAS-102,TAS 102	Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Trifluridine/tipiracil hydrochloride mixture (TAS-102) 是一种新型口服组合药物，含有摩尔比为 2:1 的曲氟尿苷(TFT) 和盐酸替吡嘧啶 (TTP)。它主要通过抑制胸苷酸合酶 (TS) 和掺入 DNA 来显示抗肿瘤活性。
T7318	Elimusertib BAY-1895344	ATM/ATR	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Elimusertib (BAY-1895344) 是一种可口服的选择性ATR 抑制剂，IC50值为 7 nM。它具有抗肿瘤活性，可研究实体瘤和淋巴瘤。
T77440	Codrituzumab RG-7686,RO5137382,GC33
	Codrituzumab (GC3）是一种人源化针对 glypican-3 肝癌蛋白的抗体，可与索拉非尼联合使用来研究不可治愈的晚期肝细胞癌 (HCC）。
T8875	CD73-IN-3 EX-A4254,LY-3475070	CD73	Immunology/Inflammation
	CD73-IN-3 (LY-3475070) 是一种有效的选择性 CD73 抑制剂，IC50 为 28 nM，具有癌症的研究潜力。
T8856	Ascorbyl Propyl Hyaluronate	Others	Others
	Ascorbyl Propyl Hyaluronate 是透明质酸和维生素 C 的完美结合，克服了维生素 C 的不稳定性，是改善皱纹、滋润、镇静肌肤、美白的优质原料。
T1595	Nevirapine NSC 641530,奈韦拉平,BI-RG 587,奈伟拉平,NVP	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Nevirapine (NVP) 是一种 HIV-1逆转录酶非核苷抑制剂，Ki 值为 270 μM，可用于研究 HIV/AIDS。
T35394	Sintilimab (anti-PD-1) IBI308,Sintilimab (anti-PD-1)	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	Sintilimab (IBI308) 是一种人源化的 IgG4 单克隆抗体，具有显著的抗肿瘤活性，通过与 PD-1 结合从而阻断 PD-1 与其配体 (PD-L1 和 PL-L2) 的相互作用，进而恢复内源性抗肿瘤 T 细胞反应。Sintilimab 联合其他化合物来治疗经典霍奇金淋巴瘤、非小细胞肺癌和食管癌。
T0930	Sulfadiazine Sulphadiazine,磺胺嘧啶	Antibacterial; Antibiotic; Parasite; Autophagy	Autophagy; Microbiology/Virology
	Sulfadiazine (Sulphadiazine) 是一种磺胺类抗生素具有抗疟活性，可研究弓形虫病。
T77466	Tremelimumab Ticilimumab,CP-675206	Others	Others
	Tremelimumab 是一种细胞毒性T淋巴细胞相关抗原-4（CTLA-4）阻断抗体.Tremelimumab 常与 Durvalumab 联合使用来治疗肝癌、肺癌等实体癌。
T9718	Ethoxylated hydrogenated castor oil	Others	Others
	Ethoxylated hydrogenated castor oil 是一种聚乙二醇与天然蓖麻油的混合物，可用于水包油 (o/w) 乳浊液的乳化和增溶，是动物实验的良好助溶剂。
T9277	ALC-0315
	ALC-0315是一种可电离的氨基脂质，已与其他脂质组合用于形成脂质纳米颗粒。脂质纳米颗粒已经用于 mRNA (COVID-19) 疫苗的研究。
T2324	Darunavir 地瑞那韦,达芦那韦,TMC114	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Darunavir (TMC114) 是一种 HIV 蛋白酶抑制剂，用于治疗艾滋病和 HIV 感染。由于单独使用时会出现抗病毒药物耐药性，因此与其他抗 HIV 药物联合使用。
T9498	BAY-8400	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	BAY-8400是一种具有口服活性、有效和选择性 DNA 依赖蛋白激酶 (DNA-PK) 抑制剂(IC50=81 nM)，与靶向α疗法联合使用显示协同疗效。BAY-8400 可用于癌症研究。
T76788	Demcizumab OMP 21M18	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Demcizumab (OMP 21M18) 是一种抗 DLL4 单克隆抗体。Demcizumab 是一种有效的 Notch 通路抑制剂。Demcizumab 在多种癌症模型中无论使单独还联合化疗试剂使用都是有效的。
T1784	Everolimus 依维莫司,RAD001,SDZ-RAD	Apoptosis; Others; mTOR; Autophagy	Apoptosis; Autophagy; Others; PI3K/Akt/mTOR signaling
	Everolimus (SDZ-RAD) 是 Rapamycin 的衍生物，也是一种口服活性的mTOR1选择性抑制剂。它与FKBP-12结合可产生免疫抑制复合物，还抑制肿瘤细胞增殖并诱导细胞凋亡和自噬，有免疫抑制和抗癌活性。
T4100	AS8351 NSC51355,AS-8351,AS 8351	Histone Demethylase	Chromatin/Epigenetic
	AS8351 (NSC51355) 是一种组蛋白去甲基化酶抑制剂，可以诱导人胎儿肺成纤维细胞重编程为功能性心肌细胞。
T6246	Cobicistat Tybost,GS-9350,考西司他	P450; HIV Protease	Metabolism; Microbiology/Virology; Proteases/Proteasome
	Cobicistat (GS-9350) 是一种细胞色素酶P450 3A 的选择性抑制剂，IC50值为30-285 nM。它是一种药代动力学增强剂，可增强抗 HIV 药物的吸收。
T1649	Tenofovir 替诺福韦,泰诺福韦,PMPA,TDF,GS 1278	HBV; HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Tenofovir (GS 1278) 是一种核苷酸逆转录酶抑制剂，可研究 HIV 和慢性乙型肝炎。

化合物

Ascorbic acid, rutoside drug combination

Cat.No: T23757

Synonym: Rutinoscorbin,Rutascorbin,Ruta C 60,Cerutin

Cat.No: T12829

Synonym: 沙美特罗,GR33343X

Target: Adrenergic Receptor

Cat.No: T7614

Synonym: GW776C85,5-Ethynyluracil

Target: Others

Cat.No: T3661

Synonym: ACY241,HDAC-IN-2

Target: HDAC

Piperaquine tetraphosphate tetrahydrate

Cat.No: T7744

Synonym: 4,4'-(1,3-丙烷双-4,1-哌嗪基)双(7-氯喹啉)磷酸盐水合物,四磷酸哌喹四水合物

Target: Parasite

Salmeterol Xinafoate

Cat.No: T6653

Synonym: Salmetedur,昔美酸沙美特罗,沙美特罗昔萘酸酯,GR 33343X xinafoate,Arial

Target: HIV Protease, Adrenergic Receptor

Cat.No: T7532

Target: Parasite

Cat.No: T3266

Synonym: Benflumetol,dl-Benflumelol,苯芴醇

Target: Others, Parasite, Autophagy

Cat.No: T2554

Target: Others

(S, R)-LSN 3318839

Cat.No: T63166L

Synonym: (S, R)-LSN 3318839(Isomer-2764704-18-7)

Target: Glucagon Receptor

Cat.No: T7537

Synonym: 炔诺肟酯,诺孕酯

Target: Progesterone Receptor

Cat.No: T1430

Synonym: CS-443,N-Benzoyl-β-alanine,倍他米隆

Target: Antibacterial, Antibiotic

Cat.No: T2239L

Synonym: 雷特格韦,MK-0518

Target: HIV Protease, Integrase

L-797,591 hydrochloride

Cat.No: T27787L

Synonym: L-797,591 hydrochloride(217480-24-5 Free base)

Cat.No: T65232

Synonym: N-(2-Hydroxyethyl)ethylenediaminetriacetic acid

Target: Others

Azido-PEG1-CH2CO2H

Cat.No: T14408

Synonym: 4-哌啶酮缩乙二醇

Target: Others, PROTAC Linker

Cat.No: T7045

Synonym: Nexiclon,Catapres,Kapvay,可乐定

Target: Adrenergic Receptor

Sultamicillin Tosylate

Cat.No: T3139

Synonym: Bacimex,舒巴西林,舒他西林甲苯磺酸盐,Unacim orale

Target: Antibacterial, Antibiotic

Cat.No: T76877

Synonym: RG-7444,B-701,MFGR-1877S

Target: FGFR

Ethynodiol diacetate

Cat.No: T0996

Synonym: Ethynodiol acetate,双醋炔诺醇,8080 CB

Target: Estrogen/progestogen Receptor, Progesterone Receptor

(S)-Mirtazapine

Cat.No: T12632L

Synonym: (S)-6-Azamianserin,(S)-Org3770

Target: 5-HT Receptor

Cat.No: T67964

Target: Microtubule Associated

Gadopentetate dimeglumine

Cat.No: T4506

Synonym: Meglumine gadopentetate,SH-L-451A,Gd-DTPA,Gadopentetic acid dimeglumine,钆喷酸葡胺,Gadopentetic acid dimeglumine salt

Target: Others

Atazanavir sulfate

Cat.No: T0100

Synonym: 阿扎那韦硫酸盐,BMS-232632,BMS-232632 sulfate,硫酸阿扎那韦

Target: P450, SARS-CoV, HIV Protease, P-gp

Norethindrone acetate

Cat.No: T40598

Synonym: 19-Norethindroneacetate

Target: Estrogen Receptor/ERR, Progesterone Receptor

Cat.No: T19080

Synonym: 1,2-二油酰-SN-甘油-3-磷酰乙醇胺

Target: Others

Cat.No: T2204

Synonym: 二氨藜芦啶,EGIS-5645,敌菌净,CCRIS-3784,AI3-23935

Target: DHFR, Antifolate, Antibacterial

Cat.No: T21432

Synonym: (±)-Molindone,Moban,Molindonum,SPN-810M

Target: Dopamine Receptor

Cat.No: T1119

Synonym: 雷沙吉兰,AGN1135,TVP1012

Target: BCL, MAO, Monoamine Oxidase

Cat.No: T9585

Synonym: 3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide

Target: Raf

Cat.No: T60009

Target: P-gp

Darunavir Ethanolate

Cat.No: T3335

Synonym: 地瑞那韦乙醇盐,UIC 94017,Darunavir Ethanolate,TMC114,达芦那韦乙醇

Target: HIV Protease

Trifluridine/tipiracil hydrochloride mixture

Cat.No: T3658

Synonym: Trifluridine-tipiracil hydrochloride mixture,TAS102,TAS-102,TAS 102

Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis

Cat.No: T7318

Synonym: BAY-1895344

Target: ATM/ATR

Cat.No: T77440

Synonym: RG-7686,RO5137382,GC33

Cat.No: T8875

Synonym: EX-A4254,LY-3475070

Target: CD73

Ascorbyl Propyl Hyaluronate

Cat.No: T8856

Target: Others

Cat.No: T1595

Synonym: NSC 641530,奈韦拉平,BI-RG 587,奈伟拉平,NVP

Target: HIV Protease, Reverse Transcriptase

Sintilimab (anti-PD-1)

Cat.No: T35394

Synonym: IBI308,Sintilimab (anti-PD-1)

Target: PD-1/PD-L1

Cat.No: T0930

Synonym: Sulphadiazine,磺胺嘧啶

Target: Antibacterial, Antibiotic, Parasite, Autophagy

Cat.No: T77466

Synonym: Ticilimumab,CP-675206

Target: Others

Ethoxylated hydrogenated castor oil

Cat.No: T9718

Target: Others

Cat.No: T9277

Cat.No: T2324

Synonym: 地瑞那韦,达芦那韦,TMC114

Target: HIV Protease

Cat.No: T9498

Target: DNA-PK

Cat.No: T76788

Synonym: OMP 21M18

Target: Gamma-secretase

Cat.No: T1784

Synonym: 依维莫司,RAD001,SDZ-RAD

Target: Apoptosis, Others, mTOR, Autophagy

Cat.No: T4100

Synonym: NSC51355,AS-8351,AS 8351

Target: Histone Demethylase

Cat.No: T6246

Synonym: Tybost,GS-9350,考西司他

Target: P450, HIV Protease

Cat.No: T1649

Synonym: 替诺福韦,泰诺福韦,PMPA,TDF,GS 1278

Target: HBV, HIV Protease, Reverse Transcriptase

Cat. No.	Product Name	Target	Signaling Pathways
TN2943	3-Hydroxy-6-methoxyflavone	Others	Others
	3-Hydroxy-6-methoxyflavone 可与抗生素联合用药来治疗 ESKAPE 病原体感染。
TJS0339	Coumarin-3-carboxylic acid 香豆素-3-羧酸,3-Carboxycoumarin	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Coumarin-3-carboxylic acid (3-Carboxycoumarin) 是一种合成香豆素的重要起始化合物。其中香豆素是具有多种生物活性的天然产物。它的镧系复合物对 K-562 细胞具有抗增殖活性。
T24403	Folinic acid HSDB 6544,Leucovorin	Endogenous Metabolite; Antifolate	Cell Cycle/Checkpoint; Metabolism
	Folinic acid (Leucovorin) 是一种可用于治疗甲氨蝶呤的生物叶酸，通常与 Methotrexate (MTX) 联用来降低 MTX 诱导的毒性，可用于辅助治疗结肠癌。
T0004	Salicylamide 水杨酰胺,Salamide,2-Hydroxybenzamide	COX	Immunology/Inflammation; Neuroscience
	Salicylamide(2-Hydroxybenzamide) 是一种止痛剂和抗热解药剂，是一种微粒体 UDP-葡糖醛酸基转移酶抑制剂。
TN1877	Lonicerin 忍冬苦苷,金银花	Apoptosis; Antibacterial	Apoptosis; Microbiology/Virology
	Lonicerin 是一种抗藻酸盐分泌蛋白的黄酮类化合物，对铜绿假单胞菌有抑制作用。它可预防脂多糖诱导的急性肺损伤的炎症和细胞凋亡。
T4S0094	Hydroxygenkwanin 羟基芫花素,Luteolin 7-methylether,7-O-Methylluteolin	Antioxidant	oxidation-reduction
	Hydroxygenkwanin (Luteolin 7-methylether) 是一种丁香达芙妮的主要成分，是一种天然的类黄酮化合物。它具有抗氧化，抗神经胶质瘤能力和抗癌作用。
T1589	D-Cycloserine RO-1-9213,D-环丝氨酸	Others; Antibacterial; Antibiotic; iGluR	Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Others
	D-Cycloserine (RO-1-9213) 是一种抗生素，靶向细菌细胞壁肽聚糖生物合成酶。它是一种NMDA 部分激动剂，可以改善认知功能，可研究耐多药结核病。
T4915	β-Glycerophosphate disodium salt hydrate	Phosphatase; Endogenous Metabolite	Metabolism
	β-Glycerophosphate disodium salt hydrate 是一种磷酸酶抑制剂，是内源性代谢产物的一种。
T6S1683	Demethoxycurcumin Curcumin II,去甲氧基姜黄素,Desmethoxycurcumin,脱甲氧姜黄,Monodemethoxycurcumin	Apoptosis; Antioxidant; Antibacterial; Autophagy	Apoptosis; Autophagy; Microbiology/Virology; oxidation-reduction
	Demethoxycurcumin (Desmethoxycurcumin) 是姜黄素的主要活性成分，有抗炎和抗癌作用。
T3S0364	L-Arginine L-精氨酸,L-Arg,(S)-(+)-Arginine	IL Receptor; Endogenous Metabolite; NO Synthase	Immunology/Inflammation; Metabolism
	L-Arginine (L-Arg) 是内皮型一氧化氮合酶(eNOS) 的底物。L-Arginine 通过阳离子氨基酸转运体家族转运到血管平滑肌细胞，并被代谢成一氧化氮、多胺或 L-脯氨酸。
TN1362	Afzelin 阿福豆苷,Kaempferol-3-O-rhamnoside	PTEN; p38 MAPK; TNF; Mitochondrial Metabolism; Antibacterial; Prostaglandin Receptor; Autophagy	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; MAPK; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Afzelin (Kaempferol-3-O-rhamnoside) 具有多种细胞活性，例如 DNA 保护、抗菌、抗氧化和抗炎以及 UV 吸收活性，并且可以通过 UV 吸收和细胞活性的组合保护人体皮肤免受 UVB 引起的损伤。 Afzelin 减轻线粒体损伤，增强线粒体生物合成并降低线粒体自噬相关蛋白、parkin 和 putative kinase 1 的水平。
T5074	Cholesteryl palmitate	Others; Endogenous Metabolite	Metabolism; Others
	Cholesteryl palmitate 是一种慢性间质性肺炎的有用预后生物标志物。
T5S0053	Coptisine 黄连碱,Coptisin	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Coptisine (Coptisin) 是一种从黄连中分离到的生物碱，是非竞争性的IDO 抑制剂，Ki=为 5.8 μM，IC50=6.3 μM。
T2S1865	Octyl gallate Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯	Antioxidant; Influenza Virus; Reactive Oxygen Species; Antibacterial; Antifungal; HSV	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; oxidation-reduction
	Octyl gallate (Octyl 3,4,5-trihydroxybenzoate) 具有抗菌、抗氧化作用，有选择性和敏感性的荧光特性，广泛用作食品添加剂。它对 HSV-1，水泡性口炎病毒和脊髓灰质炎病毒有显著的抗病毒作用。
T4S1551	Cinnamaldehyde Cinnamic Aldehyde,肉桂醛	HIF	Angiogenesis; Chromatin/Epigenetic
	Cinnamaldehyde (Cinnamic Aldehyde) 具有解热作用。它是镇静剂。它抑制MDA-MB-435S 细胞的侵袭能力与下调miR-27a 的表达有关。它诱导活性氧的产生，发挥血管扩张和抗癌作用。它似乎是一种有希望的候选药物，可作为与 5-氟尿嘧啶 (5-FU) 和奥沙利铂 (OXA) 这两种用于 CRC 治疗的化疗药物联合治疗的辅助剂。其作用的可能机制可能涉及药物代谢基因的调节。它在抑制黑色素瘤的发生和发展方面具有一定的作用，其作用机制可能表现为抑制VEGF 和HIF-α的表达，从而使血管模拟和黑色素瘤细胞新生血管的形成，促进肿瘤的生长。
T11895	Luteolin-7-rutinoside	Others	Others
	Luteolin-7-rutinoside has both antifungal activities and anti-arthritic, can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection.
TN2524	1-Acetyl-β-carboline 1-Acetyl-beta-carboline	Antifection	Microbiology/Virology
	Combination of 1-acetyl-beta-carboline with ampicillin exhibits synergistic antibacterial activity against MRSA.
TN5466	Boeravinone B
	Boeravinone B, a novel efflux pump inhibitor, apart from inhibiting the MdeA mediated efflux, also significantly inhibit the biofilm formation of S. aureus, boeravinone B may be used in combination with mupirocin for further development. Boeravinone B exh
TN1349	9-Hydroxycalabaxanthone	Antifection	Microbiology/Virology
	9-Hydroxycalabaxanthone exhibits cytotoxicity against the HT-29 cell line with ED50 values of 9.1 microM. The combination of 9-hydroxycalabaxanthone with α±-mangostin shows the synergistic antimalarial interaction in both clones.
T40859	5-Hydroxy-8-methoxypsoralen 5-Hydroxyxanthotoxin,5-Hydroxy-8-methoxypsoralen
	5-Hydroxy-8-methoxypsoralen (5-Hydroxyxanthotoxin) is a metabolite derived from Xanthotoxin, which acts as a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450). It is employed as an agent for the treatment of psoriasis, eczema, vitiligo, and certain cutaneous Lymphomas, in combination with phototherapy involving exposure to sunlight.
TMA1008	Ganoderic acid S	Others	Others
	A novel combination of triterpenoids includes at least ganoderic acid S (GAS), ganoderic acid T (GAT), ganoderic acid Me (GAMe), ganoderic acid R (GAR), and ganodermic acid S (GMAS), the composition is suitable for the treatment or prophylaxis of colon ca
TN1498	Cimigenol	Others	Others
	Cimigenol is a potential antitumor compound, combination of it with an autophagy inhibitor may be a valuable strategy for the chemoprevention or treatment of colon cancer. It exerted potent cytotoxic activity against SMMC-7721 (7.87μM) and A-549 (12.16 μM
T37751	Streptazolin
	Streptazolin is a fungal metabolite originally isolated from S. viridochromogenes. It increases NF-κB activity when used at concentrations ranging from 60 to 130 μg/ml, at least in part, via PI3K signaling. Streptazolin enhances TNF-α secretion induced by LPS and enhances IL-8 secretion when used alone or in combination with LPS in THP-1 Blue cells.
T14047	5-Aminolevulinic acid 5-Amino-4-oxopentanoic acid	Others	Others
	5-Aminolevulinic acid 是血红素合成的中间体，是卟啉合成途径中的一个化合物。它是一种光敏剂、抗肿瘤剂和前药。它也可以(以盐酸盐的形式)与蓝光照明结合使用，用于治疗面部或头皮的轻度至中度厚的光化性角化病。
T36886	Pestalotin
	Pestalotin is a fungal metabolite originally isolated from P. cryptomeriaecola with diverse biological activities. It induces reducing sugar release in embryoless rice endosperms when used at concentrations ranging from 3 to 100 mg/L and enhances growth of rice seedlings (O. sativa) when used in combination with gibberellin A3 at concentrations ranging from 30 to 500 mg/L. Pestalotin has antifungal activity, reducing the growth of C. albicans, C. neoformans, T. rubrum, and A. fumigatus (MICs = 1...
T36417	Nargenicin Antibiotic 47444
	Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive and Gram-negative bacteria (MICs = >80 μg/ml). [1] It dose-dependently inhibits S. aureus DnaE in the presence of DNase I-activated DNA and E. coli DnaE when used at concentrations of 0.00001-0.1 and 0.01-100 μg/mL, respectively. [2] In murine BV-2 microglial cells, nargenicin (...
TN3708	Coronarin D	BCL; c-Myc; TNF; NF-κB; Caspase; COX; Antifection	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome
	Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were 2 and 4 mg/mL, respectively; it is active against tested Gram-positive bacteria, i
TN4291	Isofuranodiene	IL Receptor; NOS	Immunology/Inflammation
	Isofuranodiene protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver diseases. Isofuranodiene has anticancer activity, by inhibiting the proliferation and inducing apo

天然产物

3-Hydroxy-6-methoxyflavone

Cat.No: TN2943

Target: Others

Coumarin-3-carboxylic acid

Cat.No: TJS0339

Synonym: 香豆素-3-羧酸,3-Carboxycoumarin

Target: VEGFR

Cat.No: T24403

Synonym: HSDB 6544,Leucovorin

Target: Endogenous Metabolite, Antifolate

Cat.No: T0004

Synonym: 水杨酰胺,Salamide,2-Hydroxybenzamide

Target: COX

Cat.No: TN1877

Synonym: 忍冬苦苷,金银花

Target: Apoptosis, Antibacterial

Hydroxygenkwanin

Cat.No: T4S0094

Synonym: 羟基芫花素,Luteolin 7-methylether,7-O-Methylluteolin

Target: Antioxidant

Cat.No: T1589

Synonym: RO-1-9213,D-环丝氨酸

Target: Others, Antibacterial, Antibiotic, iGluR

β-Glycerophosphate disodium salt hydrate

Cat.No: T4915

Target: Phosphatase, Endogenous Metabolite

Demethoxycurcumin

Cat.No: T6S1683

Synonym: Curcumin II,去甲氧基姜黄素,Desmethoxycurcumin,脱甲氧姜黄,Monodemethoxycurcumin

Target: Apoptosis, Antioxidant, Antibacterial, Autophagy

Cat.No: T3S0364

Synonym: L-精氨酸,L-Arg,(S)-(+)-Arginine

Target: IL Receptor, Endogenous Metabolite, NO Synthase

Cat.No: TN1362

Synonym: 阿福豆苷,Kaempferol-3-O-rhamnoside

Target: PTEN, p38 MAPK, TNF, Mitochondrial Metabolism, Antibacterial, Prostaglandin Receptor, Autophagy

Cholesteryl palmitate

Cat.No: T5074

Target: Others, Endogenous Metabolite

Cat.No: T5S0053

Synonym: 黄连碱,Coptisin

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T2S1865

Synonym: Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯

Target: Antioxidant, Influenza Virus, Reactive Oxygen Species, Antibacterial, Antifungal, HSV

Cat.No: T4S1551

Synonym: Cinnamic Aldehyde,肉桂醛

Target: HIF

Luteolin-7-rutinoside

Cat.No: T11895

Target: Others

1-Acetyl-β-carboline

Cat.No: TN2524

Synonym: 1-Acetyl-beta-carboline

Target: Antifection

Cat.No: TN5466

9-Hydroxycalabaxanthone

Cat.No: TN1349

Target: Antifection

5-Hydroxy-8-methoxypsoralen

Cat.No: T40859

Synonym: 5-Hydroxyxanthotoxin,5-Hydroxy-8-methoxypsoralen

Ganoderic acid S

Cat.No: TMA1008

Target: Others

Cat.No: TN1498

Target: Others

Cat.No: T37751

5-Aminolevulinic acid

Cat.No: T14047

Synonym: 5-Amino-4-oxopentanoic acid

Target: Others

Cat.No: T36886

Cat.No: T36417

Synonym: Antibiotic 47444

Cat.No: TN3708

Target: BCL, c-Myc, TNF, NF-κB, Caspase, COX, Antifection

Cat.No: TN4291

Target: IL Receptor, NOS

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