首页工具

登录

搜索结果

Search Results for " assay "

523

抑制剂 & 化合物

62

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T21343	PTZ-343 PTZ-343 sodium,PTZ 343,吩噻嗪-10-基-丙基磺酸钠盐	Others	Others
	PTZ-343 是一种鲁米诺的强效发光增强剂 (enhancer)。它极大的增强了过氧化物酶催化的鲁米诺化学发光氧化反应 (>80%) 的光输出。
T10924	Cysteine protease inhibitor-2	Cysteine Protease	Proteases/Proteasome
	Cysteine protease inhibitor-2 是半胱氨酸蛋白酶抑制剂。
T9693	TBAP-001	Raf	MAPK
	TBAP-001是RAF 激酶的泛抑制剂，IC50为 62 nM。
T12347	p38-α MAPK-IN-1	p38 MAPK; Autophagy	Autophagy; MAPK
	p38-α MAPK-IN-1 是一种 MAPK14 (p38-α) 抑制剂，在 EFC 置换试验和 HTRF 试验中 IC50 分别为 2300 nM 和 5500 nM。
T7225	AnaMorelin hydrochloride RC-1291 hydrochloride,阿拉莫林盐酸盐,ONO-7643 hydrochloride	GHSR	GPCR/G Protein
	AnaMorelin hydrochloride (RC-1291 hydrochloride) 是生长素受体激动剂，根据 FLIPR 检测，得到 EC50=0.74 nM。
T37591	IMP-1710	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	IMP-1710 是一种选择性 UCH-L1 抑制剂，在荧光偏振测定中的 IC50 值为 38 nM。
T16727	Relacorilant CORT 125134	Glucocorticoid Receptor	Endocrinology/Hormones
	Relacorilant 是一种选择性和口服生物可利用的糖皮质激素受体拮抗剂（HepG2 TAT 试验中的 Kis 为 7.2 nM，在基于细胞的试验中对大鼠、人和猴糖皮质激素受体的 Kis 分别为 12、81.2、210 nM）。它具有治疗库欣综合征的潜力。
T5410	PD158780	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	PD158780是一种EGFR 家族抑制剂，对EGFR、ErbB2、ErbB3和ErbB4的IC50值分别为8 μM、49、52 和 52 nM。
T8930	CID44216842 KUC103479N-02	CDK; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	CID44216842 (KUC103479N-02) 是Cdc42选择性抑制剂。在 GDP 结合测定中，它对 Cdc42 野生型和 Cdc42Q61L 突变型的EC50分别为 0.3 和 0.5 μM。在 GTP 结合测定中，它对 Cdc42 野生型和 Cdc42Q61L 突变型的EC50分别为 1.0 和 1.2 μM。它可用作分子探针。
T6935	Nirogacestat PF-03084014,PF-3084014,PF03084014,PF 03084014	Apoptosis; Gamma-secretase	Apoptosis; Neuroscience; Proteases/Proteasome; Stem Cells
	Nirogacestat (PF 03084014) 是一种具有口服活性的，可逆的，非竞争性的，选择性γ-secretase 抑制剂，IC50为 6.2 nM。它抑制 Notch 信号通路，可研究 Notch 受体依赖性肿瘤。
T12856	SC-26196 ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈	Others	Others
	SC-26196 是一种 Delta6 去饱和酶 (D6D, FADS2) 抑制剂 (在大鼠肝微粒体中，IC50=0.2 µM)，具有口服活性，具有抗炎作用。
T12589	PI3Kα/mTOR-IN-1	PI3K; mTOR	PI3K/Akt/mTOR signaling
	PI3Kα/mTOR-IN-1是一种有效的 PI3Kβ/mTOR 双重抑制剂。在细胞测定中，PI3Kα/mTOR-IN-1的 IC50为7nM，在无细胞测定中 mTOR 和PI3Kβ的Kis 分别为12.5nM 和10.6nM。
T13000	Src Inhibitor 3	Others; Src	Angiogenesis; Others; Tyrosine Kinase/Adaptors
	Src Inhibitor 3 是一种有效的 c-terminal Src 激酶抑制剂（CSK HTRF 中 IC50 <3 nM，Caliper 中 IC50 <4 nM）。 Src Inhibitor 3 增加由 T 细胞受体信号传导诱导的 T 细胞增殖。
T39785L	TH5427	NUDIX hydrolase	Metabolism
	TH5427 在 NUDT5 活性和 ADP-核糖代谢中有研究的价值。它阻断孕激素依赖性、PAR 衍生的核 ATP 合成以及随后的乳腺癌细胞染色质重塑、基因调控和增殖。NUDT5是乳腺癌细胞激素依赖性基因调控和增殖的变阻器。
T1971	WAY-262611	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	WAY262611是一种 Wnt/β- 联蛋白激动剂，也是一种Dkk1的抑制剂。它能够增加骨形成速率，在 TCF- 荧光素酶测定实验中的EC50=0.63 μM。
T4018	WST-8 WST8	Others	Others
	WST-8 是水溶性的四唑染料，WTS-8测定法的灵敏度比常规MTS 检测高。
T16115	MLi-2	LRRK2	Autophagy
	MLi-2 是一种结构新颖、高效、选择性的 LRRK2 激酶抑制剂，具有中枢神经系统活性，IC50为 0.76 nM，有潜力用于帕金森氏病。
T7904	SR 19881	Estrogen/progestogen Receptor	Endocrinology/Hormones
	SR 19881 是 ERRγ 的完全激动剂（结合试验中的 EC50 值为 0.39 μM，基于细胞的试验中 EC50 值为 4.7 μM）。
T4988	Boceprevir SCH 503034,EBP 520,波普瑞韦	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Boceprevir (SCH 503034) 是一种口服有效的选择性 HCV NS3 蛋白酶抑制剂。在酶试验中的 Ki 为 14 nM，在基于细胞的复制子试验中 EC90 为 350 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。
T20490	Z-Arg(Z)2-OH NSC120011,NSC-120011,NSC 120011,Tris(benzyloxycarbonyl)arginine	Others	Others
	Z-Arg(Z)2-OH 可用于检测螨匀浆中的蛋白水解活性的实验中。
T9322	N-Phenylacrylamide	Others	Others
	N-Phenylacrylamide 通过荧光转酰胺法抑制人重组 TGM2。
T4470	Pyridostatin TFA	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Pyridostatin TFA 是一种 G-四链体稳定剂，靶向原癌基因 Src，降低人乳腺癌细胞 SRC 蛋白水平和 SRC 依赖的细胞运动。它通过诱导复制和转录依赖的 DNA 损伤促进人类癌细胞生长停滞。
T12128	Mutant IDH1-IN-2	Isocitrate Dehydrogenase (IDH)	Metabolism
	Mutant IDH1-IN-2是突变型异柠檬酸脱氢酶蛋白抑制剂, 在荧光生物化学检测中IC50为16.6 nM，LS-MS 生物化学检测中IC50为＜22 nM,。
T6868	KYA1797K	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	KYA1797K 是一种选择性 Wnt/β-catenin 抑制剂(IC50:0.75 µM)。
T8765	iGOT1-01	Others	Others
	iGOT1-01 是一种天冬氨酸转氨酶 1 (谷氨酸草酰乙酸转氨酶 1；GOT1) 抑制剂，在 GOT1/GLOX/HRP 测定中IC50为 11.3 μM，在 MDH 偶联 GOT1 酶法测定中IC50为 85 μM。它显示出抗癌活性。
T9681	MAK-683 hydrochloride	Histone Methyltransferase	Chromatin/Epigenetic
	MAK683 hydrochloride 是胚胎外胚层发育 (EED) 抑制剂。MAK683 hydrochloride 在 EED Alphascreen， ELISA 和 LC-MS 试验中测得的IC50 值分别为 59，26，89 nM。
T9994	WAY-620521	Others	Others
	WAY-620521是一种用于细胞的高通量测定小分子。
T4219	Autophinib	PI3K; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	Autophinib 是一种选择性细胞自噬抑制剂，通过靶向 VPS34来抑制饥饿或雷帕霉素诱导的细胞自噬，对于饥饿和雷帕霉素诱导的自噬，IC50值分别为 90 nM 和 40 nM。它还是 ATP 竞争性 VPS34抑制剂，其 IC50值为 19 nM。
T9448	IL-17A inhibitor 1	IL Receptor	Immunology/Inflammation
	IL-17A inhibitor 1 是 IL-17A 的抑制剂，在alphalisa assay 中的IC50为 <9.45 nM。IL-17A inhibitor 1抑制HT-29 细胞的 IC50 值为 9.3 nM。
T18997	GPDA Glycylproline p-nitroanilide tosylate,GPN	Others	Others
	GPDA (Glycylproline p-nitroanilide tosylate) 是一种酶促反应检测底物，用于检测脯氨酰二肽氨基肽酶。
T4390	ML221	Apelin receptor; Arrestin	GPCR/G Protein
	ML221 是apelin (APJ)拮抗剂，能够抑制 apelin-13 介导的 APJ 的活化，在 cAMP 试验和 β-arrestin 实验中，IC50值分别为 0.70 μM 和 1.75 μM，EC80值均为 10 nM。
T17203	UNC0224	Histone Methyltransferase	Chromatin/Epigenetic
	UNC0224 是 G9a 的特异性抑制剂，Ki 为 2.6 nM，IC50 为 15 nM。 UNC0224 还有效抑制 GLP，IC50 值为 20-58 nM。
T11561	HIF-2α-IN-2	HIF/HIF Prolyl-Hydroxylase; HIF	Angiogenesis; Chromatin/Epigenetic; Metabolism
	HIF-2α-IN-2 是低氧诱导因子抑制剂，IC50=16 nM。
T10319	Anamorelin RC-1291,阿拉莫林,ONO-7643	GHSR	GPCR/G Protein
	Anamorelin (ONO-7643) 是新型ghrelin receptor 激动剂，根据FLIPR 检测，得到其EC50=0.74 nM。
T1989	Luminespib AUY922,VER-52296,NVP-AUY922	Apoptosis; HSP; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Metabolism
	Luminespib (VER-52296) 是一种 HSP90抑制剂，抑制 HSP90α 和 HSP90β 的 IC50分别为 7.8 和 21 nM。
T15665	KJ Pyr 9	c-Myc; Autophagy	Autophagy; Cell Cycle/Checkpoint
	KJ Pyr 9 是一种 MYC 的抑制剂，在体外实验中的 Kd 值为 6.5 nM。
T2001	PF-573228 PF 573228	Apoptosis; FAK	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PF-573228是一种选择性的 FAK 抑制剂，对 FAK 纯化重组催化片段的 IC50值为4 nM。
T36711	FM19G11 FM19G11,HIF-1alpha/2alpha Inhibitor	HIF	Angiogenesis; Chromatin/Epigenetic
	FM19G11 是一种低氧诱导因子 (HIF) α-亚基抑制剂（在低氧诱导的荧光素酶试验中 IC50 为 80 nM）。
T9969	EZM0414	Histone Methyltransferase	Chromatin/Epigenetic
	EZM0414 是一种有效、选择性、口服生物利用度高的SETD2抑制剂，在 SETD2 生化分析中，IC50值为18 nM；在细胞分析中，IC50值为34 nM。EZM0414可用于复发或难治性多发性骨髓瘤和弥漫性大 B 细胞淋巴瘤的研究。
T2508	Binimetinib ARRY-438162,ARRY-162,MEK162	MEK; Autophagy	Autophagy; MAPK
	Binimetinib (ARRY-162) 是一种可口服的选择性 MEK1/2抑制剂，抑制MEK 的IC50为 12 nM。
T3198L	PRE-084 hydrochloride	Sigma receptor	GPCR/G Protein
	PRE-084 hydrochloride 是 σ1 的选择性激动剂在sigma 受体检测中，IC50值为44 nM。
T0238	2-(Acetyloxy)-3-Methylbenzoic Acid	Others	Others
	2-(Acetyloxy)-3-Methylbenzoic Acid 用于 qHTS 测定羟基类固醇 (17-β) 脱氢酶 4、HSD17B4 的抑制剂，活性值为 19.95 μM。
T15201	MAK683	Histone Methyltransferase	Chromatin/Epigenetic
	MAK683 是胚胎外胚层发育 (EED) 抑制剂。在 EED Alphascreen 结合、LC-MS 和 ELISA 测定中，IC50值为 59、89 和 26 nM。
T8959	OS-3-106	Dopamine Receptor	GPCR/G Protein; Neuroscience
	OS-3-106 是一种新型芳酰胺苯基哌嗪，在腺苷酸环化酶抑制试验中作为 D3R 的部分激动剂。
T2654	GSK2656157	Apoptosis; PERK; Autophagy	Apoptosis; Autophagy
	GSK2656157 是一种ATP 竞争性的PERK 选择性抑制剂，IC50值为 0.9 nM。
T2380	BIBR 1532	Apoptosis; Telomerase	Apoptosis; DNA Damage/DNA Repair
	BIBR 1532 是一种选择性端粒酶非竞争性抑制剂，IC50值为 100 nM。
T14371	Barasertib 巴拉塞替,AZD1152	Apoptosis; Aurora Kinase	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic
	Barasertib (AZD1152) 是 Barasertib-hQPA 的前体药物，在癌细胞中诱导生长停滞和凋亡。它是高度选择性的Aurora B 抑制剂，IC50值为 0.37 nM。
T2452	C646	Apoptosis; Epigenetic Reader Domain; Histone Acetyltransferase; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic
	C646 是一种竞争性组蛋白乙酰转移酶 p300选择性抑制剂，Ki 值为 400 nM，对其他乙酰转移酶作用较小。
T6070	(E/Z)-Rigosertib sodium N-[2-甲氧基-5-[[[2-(2,4,6-三甲氧基苯基)乙烯基]磺酰]甲基]苯基]甘氨酸钠盐,(E/Z) ON-01910 sodium	PLK	Cell Cycle/Checkpoint
	ON-01910 是一种非 ATP 竞争性 PLK1 抑制剂（IC50 为 9 nM，在无细胞试验中）。它对 Plk2 的选择性高出 30 倍，对 Plk3 没有活性。 Rigosertib 抑制 PI3K/Akt 通路并激活氧化应激信号。 Rigosertib 可诱导多种癌细胞凋亡。它是一种合成的苄基苯乙烯基砜类似物，具有潜在的抗肿瘤活性。
T13214L	TRPV4 agonist-1 free base OUN67600	TRP/TRPV Channel	Membrane transporter/Ion channel
	TRPV4 agonist-1 free base (OUN67600) 是有效的瞬时受体电位香草酸亚型 4 激动剂， hTRPV4 Ca2+实验中 EC50值为60 nM。

化合物

Cat.No: T21343

Synonym: PTZ-343 sodium,PTZ 343,吩噻嗪-10-基-丙基磺酸钠盐

Target: Others

Cysteine protease inhibitor-2

Cat.No: T10924

Target: Cysteine Protease

Cat.No: T9693

Target: Raf

p38-α MAPK-IN-1

Cat.No: T12347

Target: p38 MAPK, Autophagy

AnaMorelin hydrochloride

Cat.No: T7225

Synonym: RC-1291 hydrochloride,阿拉莫林盐酸盐,ONO-7643 hydrochloride

Target: GHSR

Cat.No: T37591

Target: DUB

Cat.No: T16727

Synonym: CORT 125134

Target: Glucocorticoid Receptor

Cat.No: T5410

Target: EGFR

Cat.No: T8930

Synonym: KUC103479N-02

Target: CDK, Ras

Cat.No: T6935

Synonym: PF-03084014,PF-3084014,PF03084014,PF 03084014

Target: Apoptosis, Gamma-secretase

Cat.No: T12856

Synonym: ALPHA,ALPHA-二苯基-4-[(3-吡啶亚甲基)氨基]-1-吡嗪戊腈

Target: Others

PI3Kα/mTOR-IN-1

Cat.No: T12589

Target: PI3K, mTOR

Src Inhibitor 3

Cat.No: T13000

Target: Others, Src

Cat.No: T39785L

Target: NUDIX hydrolase

Cat.No: T1971

Target: Wnt/beta-catenin

Cat.No: T4018

Synonym: WST8

Target: Others

Cat.No: T16115

Target: LRRK2

Cat.No: T7904

Target: Estrogen/progestogen Receptor

Cat.No: T4988

Synonym: SCH 503034,EBP 520,波普瑞韦

Target: HCV Protease, SARS-CoV

Cat.No: T20490

Synonym: NSC120011,NSC-120011,NSC 120011,Tris(benzyloxycarbonyl)arginine

Target: Others

N-Phenylacrylamide

Cat.No: T9322

Target: Others

Pyridostatin TFA

Cat.No: T4470

Target: DNA/RNA Synthesis

Mutant IDH1-IN-2

Cat.No: T12128

Target: Isocitrate Dehydrogenase (IDH)

Cat.No: T6868

Target: Wnt/beta-catenin

Cat.No: T8765

Target: Others

MAK-683 hydrochloride

Cat.No: T9681

Target: Histone Methyltransferase

Cat.No: T9994

Target: Others

Cat.No: T4219

Target: PI3K, Autophagy

IL-17A inhibitor 1

Cat.No: T9448

Target: IL Receptor

Cat.No: T18997

Synonym: Glycylproline p-nitroanilide tosylate,GPN

Target: Others

Cat.No: T4390

Target: Apelin receptor, Arrestin

Cat.No: T17203

Target: Histone Methyltransferase

Cat.No: T11561

Target: HIF/HIF Prolyl-Hydroxylase, HIF

Cat.No: T10319

Synonym: RC-1291,阿拉莫林,ONO-7643

Target: GHSR

Cat.No: T1989

Synonym: AUY922,VER-52296,NVP-AUY922

Target: Apoptosis, HSP, Autophagy

Cat.No: T15665

Target: c-Myc, Autophagy

Cat.No: T2001

Synonym: PF 573228

Target: Apoptosis, FAK

Cat.No: T36711

Synonym: FM19G11,HIF-1alpha/2alpha Inhibitor

Target: HIF

Cat.No: T9969

Target: Histone Methyltransferase

Cat.No: T2508

Synonym: ARRY-438162,ARRY-162,MEK162

Target: MEK, Autophagy

PRE-084 hydrochloride

Cat.No: T3198L

Target: Sigma receptor

2-(Acetyloxy)-3-Methylbenzoic Acid

Cat.No: T0238

Target: Others

Cat.No: T15201

Target: Histone Methyltransferase

Cat.No: T8959

Target: Dopamine Receptor

Cat.No: T2654

Target: Apoptosis, PERK, Autophagy

Cat.No: T2380

Target: Apoptosis, Telomerase

Cat.No: T14371

Synonym: 巴拉塞替,AZD1152

Target: Apoptosis, Aurora Kinase

Cat.No: T2452

Target: Apoptosis, Epigenetic Reader Domain, Histone Acetyltransferase, Autophagy

(E/Z)-Rigosertib sodium

Cat.No: T6070

Synonym: N-[2-甲氧基-5-[[[2-(2,4,6-三甲氧基苯基)乙烯基]磺酰]甲基]苯基]甘氨酸钠盐,(E/Z) ON-01910 sodium

Target: PLK

TRPV4 agonist-1 free base

Cat.No: T13214L

Synonym: OUN67600

Target: TRP/TRPV Channel

Cat. No.	Product Name	Target	Signaling Pathways
TN3112	5-Heneicosylresorcinol	NADPH-oxidase; Antifection	Immunology/Inflammation; Microbiology/Virology
	5-Heneicosylresorcinol 对 RBL-2H3 细胞中 β-己糖胺酶的释放具有抑制作用，它还可以防止 3T3-L1 细胞中甘油三酯的积累。它对红线虫、秀丽隐杆线虫和松材线虫具有杀线虫活性，ED50 值分别为 80、30 和 180 ug/mL。
T4086	Glycyl-L-leucine 甘氨酰-L-亮氨酸,Gly-Leu	Others	Others
	Glycyl-L-leucine (Gly-Leu) 是一种可用作糖基亮氨酸二肽酶底物的二肽。
T2814	Cryptotanshinone 隐丹参酮,Cryptotanshinon,Tanshinone c,隐丹参醌	STAT; Autophagy	Autophagy; JAK/STAT signaling; Stem Cells
	Cryptotanshinone (Cryptotanshinon) 是从丹参的根中提取的一种天然产物，抑制STAT3的IC50为4.6 μM，具有抗肿瘤活性。
T5S1550	Cinnamyl alcohol 肉桂醇,肉桂醇；beta-苯丙烯醇,Cinnamic Alcohol,Styryl Carbinol	PPAR	DNA Damage/DNA Repair; Metabolism
	Cinnamyl alcohol (Styryl Carbinol) 是从板栗花中分离得到的一种活性成分，抑制增加的 PPARγ表达，具有抗肥胖作用。
TN1112	Morellic acid	Others	Others
	Morellic acid 提取于 Garcinia Morella 中，具有抗血管生成作用。
T4S0176	Alnustone (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one,桤木酮	Others	Others
	Alnustone ((4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one) 是一种非酚双苯庚烷类化合物，在草药和香料中发现，是姜黄的成分之一，具有抗吐、抗炎作用。
TN1691	Glabrol 光甘草酚,光甘草醇	P450; NF-κB; NO Synthase; Acyltransferase	Immunology/Inflammation; Metabolism; NF-κB
	Glabrol 是分离自甘草根的乙醇提取物中的一种异戊二烯类黄酮，是一种有效且非竞争性的酰基辅酶 A：胆固醇酰基转移酶（ACAT）抑制剂，抑制大鼠肝脏微粒体 ACAT 的 IC50为 24.6 μM。
TN2030	P-Hydroxyphenethyl trans-ferulate 反式-阿魏酸对羟基苯乙酯	5-HT Receptor	GPCR/G Protein; Neuroscience
	p-Hydroxyphenethyl trans-ferulate 具有抗高血糖（酵母α-葡萄糖苷酶，IC5019.24 ± 1.73 µmol L-1），抗氧化，抗炎活性，也具有抗癌特性和血清素能特性。
T36473	trans-Nerolidol
	trans-Nerolidol is a sesquiterpene that has been found in various plants, includingC. sativa, and has diverse biological activities, including antimicrobial, antioxidant, anticancer, and insecticidal properties.1,2,3,4In a disc assay,trans-nerolidol inhibits the growth ofS. aureus,B. subtilis,E. coli, andS. cerevisiaewith zones of inhibition measuring 10, 9, 10, and 4 mm, respectively.2It reduces viability of CaCo-2 adenocarcinoma cells with an IC50value of 28.7 mg/L and reduces production of re...
T5853	Rubitecan RFS 2000,鲁比特康,9-Nitrocamptothecin	Topoisomerase	DNA Damage/DNA Repair
	Rubitecan (9-Nitrocamptothecin) 是一种与喜树碱相关的半合成药物，具有有效的抗肿瘤和抗病毒特性。它是一种 DNA 拓扑异构酶 I 抑制剂，以浓度依赖性方式抑制 DNA 拓扑异构酶 I 并在无细胞试验中增加超螺旋 DNA 的比例。
TN2086	Piperlotine A	Antibacterial	Microbiology/Virology
	Piperlotine A 是一种可从罗洛胡椒中提取得到的生物碱，具有抗血小板聚集活性。Piperlotine A 在体外试验中显示出对结核分枝杆菌的抑制作用，MIC 值为 50 ug/mL。
T36914	2-Hydroxyanthraquinone	Others	Others
	2-Hydroxyanthraquinone 是一种天然产物，显示出抗肿瘤和免疫抑制活性。
T35749	Thymohydroquinone Thymoquinol	Antioxidant; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Thymohydroquinone (Thymoquinol) 是中药材百里香、牛至和其他唇形科植物中含有的单萜酚类化合物。 Thymohydroquinone 抑制癌细胞生长、减少氧化应激和调节炎症反应，在无细胞实验中清除2,2-二苯基-1-picrylhydrazyl 自由基(IC50 = 2.4 μg/ml)，在浓度为1.6至6.4 μg/ml 的氧自由基吸收能力(ORAC)实验中，它的Trolox 当量值为2.6胸腺对苯二酚对A2780、OVCAR-8和CIS-A2780卵巢癌细胞(IC50分别为3.1、8.9和9.8 μM)和人卵巢永生化上皮细胞(IC50 = 14 μM)的生长有抑制作用，体外对恶性疟原虫也有抑制作用(IC50 = 15.9 μM)。
T1737	Genistein NPI 031L,三叶草,染料木素,金雀异黄酮	Apoptosis; EGFR; Endogenous Metabolite; Autophagy	Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Metabolism; Tyrosine Kinase/Adaptors
	Genistein (NPI 031L) 是一种大豆异黄酮，是一种多重的酪氨酸激酶抑制剂，通过改变细胞凋亡，细胞周期和血管生成以及抑制转移对多种癌症有化疗作用。
T37753	Aureusimine B	Cysteine Protease; Antibacterial	Microbiology/Virology; Proteases/Proteasome
	Aureusimine B 是一种钙蛋白酶抑制剂，由金黄色葡萄球菌生物膜产生，可能是金黄色葡萄球菌生物膜感染的潜在生物标志物。
TN6657	4-(Dimethylamino)cinnamaldehyde
	4-Dimethylaminocinnamaldehyde is a photometric reagent for primary aromatic amines. The 4-(dimethylamino)cinnamaldehyde assay is currently used to quantify proanthocyanidin (PAC) content in cranberry products.
T82640	Cyclobisdemethoxycurcumin
	Cyclobisdemethoxycurcumin，作为一种抗氧化剂，在DPPH自由基清除试验中示出约250 μM的IC50，在2-DR氧化试验中显示为15-20 μM的IC50。
TMA0245	Hexacosyl (E)-ferulate	Others	Others
	Hexacosyl (E)-ferulate displays significant antioxidant activity in the DPPH assay (RC50 = 0.0976 mg/mL). It also might be a chemotaxonomic marker in the genus Echinops.
TMA2563	Pedalitin	Tyrosinase	Proteases/Proteasome
	Pedalitin is a mixed-type inhibitor of tyrosinase. In the assay of α-glucosidase inhibition, rosmarinic acid is a competitive inhibitor, whereas both methyl rosmarinate and Pedalitin are mixed-type inhibitors.
TN1802	Isoscoparin-2′′O-glucoside 异金雀花素-2”-O-吡喃葡萄糖苷,Isoscoparin-2''-Beta-D-glucopyranoside	Others	Others
	Isoscoparin-2''-Beta-D-glucopyranoside shows prominent free radical scavenging activity in DPPH assay.
TN4602	Myricananin A	NOS	Immunology/Inflammation
	Myricadenin A exhibits anti-inflammatory activities in the iNOS assay with EC50 values of 18.1 uM.
TN3705	Coronalolide methyl ester	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Coronalolide methyl ester displays significant anti-HIV activities in the HIV-1RT assay. It and coronalolide show broad cytotoxic activity against a panel of human cancer cell lines.
T36044	17-hydroxy Venturicidin A
	17-hydroxy Venturicidin A is a macrolide fungal metabolite originally isolated from Streptomyces. It has antibiotic activity against M. luteus, B. subtilis, and S. aureus and antifungal activity against V. dahlia, Fusarium, and C. tropicalis in a disc assay.
T13679	Enniatin B	ERK	MAPK
	Enniatins B decreases the activation of ERK (p44/p42). Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 113 μM in an enzyme assay using rat liver microsomes.
TN2834	27-p-Coumaroyloxyursolic acid	Others	Others
	27-trans-p-Coumaroyloxyursolic acid and 27-cis-p-coumaroyloxyursolic acid show potent inhibitory activity in the acyl CoA cholesteryl acyl transferase (ACAT) assay.
T83467	10-O-Trans-p-methoxycinnamoylcatalpol
	10-O-Trans-p-methoxycinnamoylcatalpol 表现出抗氧化特性，DPPH 自由基清除实验中显示其 IC50 为 0.37 μM/mL。
TN3921	Effusanin B	Antifection	Microbiology/Virology
	Effusanin B shows antibacterial activity. It exhibits DNA-damaging activity in assay which employes DNA-repair deficient (RAD 52Y) and repair proficient (RAD +) yeast strains.
T38349	Talaromycesone A
	Talaromycesone A is a fungal metabolite originally isolated fromTalaromyces.1It is active againstS. epidermidisand methicillin-resistantS. aureus(MRSA) bacteria (IC50s = 3.70 and 5.48 μM, respectively). Talaromycesone A inhibits acetylcholinesterase (AChE) in a cell-free assay (IC50= 7.49 μM for the human enzyme). 1.Wu, B., Ohlendorf, B., Oesker, V., et al.Acetylcholinesterase inhibitors from a marine fungus Talaromyces sp. strain LF458Mar. Biotechnol. (NY)17(1)110-119(2015)
TN1265	3'-O-Methylorobol 3'-O-METHYLOROBOL,3'-O-甲基香豌豆苷元	Others	Others
	3'-O-Methylorobol exhibits moderate antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl free radical scavenging assay, it also exerts potential analgesic properties. 3'-O-Methylorobol can increase osteoblast differentiation.
TN4342	Izalpinine	Others	Others
	Izalpinin exhibits potent antioxidant activities in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Izalpinin exhibits inhibitory role of muscarinic receptor-related detrusor contractile activity, and it may be a promising lead compound to treat overactiv
T37543	Anhydroepiophiobolin A
	Anhydroepiophiobolin A is a sesterterpenoid fungal metabolite that has been found in B. oryzae. It is cytotoxic to HepG2 and K562 cells (IC50s = 47.1 and 35.6 μM, respectively) as well as A549, SKOV3, SK-MEL-2, XF498, and HCT15 cells (IC50s = 1.6-1.9 μg/ml). Anhydroepiophiobolin A is phytotoxic to S. viridis and D. erucoides in a leaf puncture assay.
T38104	Deoxyfusapyrone
	Deoxyfusapyrone is an α-pyrone fungal metabolite originally isolated from F. semitectum and has antifungal activity. It is active against C. neoformans, A. fumigatus, A. niger, and A. flavus human mycoses (MICs = 1.56-6.25 μg/ml). Deoxyfusapyrone is also active against a variety of filamentous fungi, but not yeast or the bacterium B. megaterium, in a disc assay.
TN3704	Coronalolide	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Coronalolide shows significant cytotoxic activities in P-388 cell line, it also displays significant anti-HIV activities in the HIV-1RT assay. Coronalolide and coronalolide methyl ester show broad cytotoxic activity against a panel of human cancer cell li
T36513	Pyranonigrin A
	Pyranonigrin A is a fungal metabolite originally isolated from Aspergillus that has antioxidant activity. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH;) free radicals in a cell-free assay (IC50 = 132.9 μM). Pyranonigrin A (10 μM) suppresses TNF-α-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs).
TN5133	3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone	HIV Protease; Topoisomerase	DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it shows considerably activity against HIV-1 reverse transcriptase. It exhibits cytotoxic activity against P-388 cell lines, it can inhibit DNA topoisomerase IIα activity, which may be responsible for the observed cytotoxicity.
T83578	(19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol
	(19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol 是一种葫芦烷型三萜。该化合物在 MTT 法检测中对癌细胞系 MCF-7、HepG2、Du145、Colon205 以及 HL-60 均未表现出抑制效果。
TN3920	Effusanin A	Raf; Antifection	MAPK; Microbiology/Virology
	Effusanin A 是一种存在于Isodon rugosus 之中的天然产物。它具有 DNA 损伤和抗菌作用。
TN5880	Mesuol
	Mesuol has antioxidant activity, it shows very high scavenging activity against DPPH radical; it also has immunomodulatory activity, can potentiate percentage neutrophil adhesion in neutrophil adhesion test in rats and phagocytosis in carbon clearance assay. Mesuol can suppress HIV-1 replication in Jurkat T cells, it inhibits TNFα-induced HIV-1-LTR transcriptional activity by targeting the nuclear factor-κB (NF-κB) pathway.
T38015	Herquline A
	Herquline A is an alkaloid fungal metabolite originally isolated from P. herquei. It inhibits cell death induced by influenza A strain A/PR/8/34 in MDCK cells with an IC50 value of 10 μg/ml and inhibits viral replication in a plaque assay in a concentration-dependent manner. Herquline A also inhibits platelet aggregation induced by ADP and platelet-activating factor (PAF) in vitro (IC50s = 180 and 240 μM, respectively).
TN4113	Garcinone E	Antifection	Microbiology/Virology
	Garcinone E is active constituents in the anticomplement assay used. Garcinone E exhibits potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC50 values below 3 µM. It has potent cytotoxic effect on all hepatocellular carcinomas cell lines as well as on the other gastric and lung cancer cell lines included in the screen, may be potentially useful for the treatment of certain types of cancer.
T35609	19-O-Acetylchaetoglobosin A
	19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated fromC. globosumthat has actin polymerization inhibitory and cytotoxic activities.1,2It inhibits actin polymerization in a cell-free assay when used at a concentration of 2 μM.219-O-Acetylchaetoglobosin A (3.2, 10, and 32 μg/ml) is cytotoxic to HeLa cervical cancer cells.1 1.Umeda, M., Ohtsubo, K., Saito, M., et al.Cytotoxicity of new cytochalasans from Chaetomium globosumExperientia31(4)435-438(1975) 2.Sekita, S., Yoshihira, ...
T83913	Mitraciliatine
	Mitraciliatine是一种在M. speciosa（泰国称为Kratom）中发现的生物碱，是μ-阿片受体（MOR）部分激动剂和κ-阿片受体（KOR）激动剂。该化合物对MOR和KOR具有选择性，与δ-阿片受体（DOR; EC50s分别为228, 218, 和 >1,000 nM，针对小鼠受体在GTPγS结合实验中的表现）。Mitraciliatine（100 nmol/动物，脑室内注射）在小鼠的热水尾部缩回实验中延长了撤回潜伏期，这一效果可以通过敲除MOR而非KOR来逆转。与吗啡不同，Mitraciliatine不会诱发过度活动或呼吸抑制。
T36815	Chevalone C
	Chevalone C is a meroterpenoid fungal metabolite originally isolated from E. chevalieri. It is active against M. tuberculosis H37Ra (MIC = 6.3 μg/ml) and is cytotoxic to BC1 human breast cancer cells (IC50 = 8.7 μg/ml). Chevalone C inhibits the growth of multidrug-resistant isolates of E. coli, S. aureus, and E. faecium in a disc diffusion assay when used at a concentration of 15 μg/disc. It also induces cell death in HCT116 colorectal carcinoma cells.
T33492	Methyl pyropheophorbide-a MPPa (Methyl pyropheophorbide-a),NSC267052,Pyropheophorbidea,MPPa,NSC-267052,NSC 267052
	Pyropheophorbide-a methyl ester (MPPa) is a PDT photosensitizer, and is also a semisynthetic natural product derived from chlorophyll a. The absorption peak of MPPa in organic solvent and in cells was at 667 and 674 nm, respectively. 3-(4,5-Dimethylthiazo
T38097	Antibiotic PF 1052
	Antibiotic PF 1052 is a fungal metabolite originally isolated from Phoma.1,2 It is active against S. aureus, S. parvulus, and C. perfringens (MICs = 3.13, 0.78, and 0.39 μg/ml, respectively), among others.1 It inhibits neutrophil migration in a wound assay using zebrafish larvae expressing GFP-labeled neutrophils, reducing pseudopodia formation and inducing rounding of neutrophils.2 Antibiotic PF 1052 is selective for neutrophil migration over macrophage migration in zebrafish larvae. It also in...
T79965	11-Oxoisomogroside V		Metabolism
	11-Oxoisomogroside V（compound 3）是从罗汉果粗提物中分离的一种葫芦苷，能够激活PGC-1α的转录活性。荧光素酶实验表明，10 μM 和 20 μM 浓度的11-Oxoisomogroside V分别将荧光素酶活性提高至 133.79% 和 143.81%。
TN5655	Broussonin B
	Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin B can induce neurite outgrowth in PC-12 cells at concentration of 50 microg/ml, and show moderate inhibitory activities against a chymotrypsin-like activity of the proteasome.B
T36992	Monocerin
	Monocerin is a fungal metabolite that has been found inF. larvarumand has diverse biological activities.1,2,3It is active against the bacteriaE. coliandB. megaterium, the phytopathogenic fungusM. violaceum, and the algaC. fuscain an agar diffusion assay when used at a concentration of 50 μg/disc.1Monocerin (17.5 μg/ml) induces mortality in adultC. erythrocephala.2It reduces root elongation in pre-germinatedS. halepenseseeds when used at a concentration of 33 ppm.3 1.Zhang, W., Krohn, K., Draeger...
T37714	Fuscin
	Fuscin is a quinonoid fungal metabolite originally isolated from O. fuscum that has diverse biological activities. It inhibits binding of the ADP/ATP translocase inhibitor atractyloside to rat liver mitochondria in an ADP-dependent manner when used at a concentration of 50 μM in a radioligand binding assay. Fuscin (20 μM) reduces the glutathione content of rat liver mitochondria to 28% of controls and inhibits NADH oxidation in sonicated pigeon heart mitochondria preparations in a concentration-...
T36438	Sporogen-AO 1
	Sporogen-AO 1 is a fungal metabolite originally isolated fromA. oryzaethat has diverse biological activities.1,2,3,4,5It inhibits HIV-1 Tat transactivation in a cell-based assay with an IC50value of 15.8 μM.4Sporogen-AO 1 is cytotoxic to HeLa, KB, and NCI H187 cancer cells (IC50s = 8.3, 9, and 5.1 μM, respectively).2,5It is active againstC. albicans(MIC = 4 mM).3 1.Tanaka, S., Wada, K., Marumo, S., et al.Structure of sporogen-ao 1, a sporogenic substance of Aspergillus oryzaeTetrahedron Lett.25(...
------------------------ 更多 ------------------------

天然产物

5-Heneicosylresorcinol

Cat.No: TN3112

Target: NADPH-oxidase, Antifection

Glycyl-L-leucine

Cat.No: T4086

Synonym: 甘氨酰-L-亮氨酸,Gly-Leu

Target: Others

Cryptotanshinone

Cat.No: T2814

Synonym: 隐丹参酮,Cryptotanshinon,Tanshinone c,隐丹参醌

Target: STAT, Autophagy

Cinnamyl alcohol

Cat.No: T5S1550

Synonym: 肉桂醇,肉桂醇；beta-苯丙烯醇,Cinnamic Alcohol,Styryl Carbinol

Target: PPAR

Cat.No: TN1112

Target: Others

Cat.No: T4S0176

Synonym: (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one,桤木酮

Target: Others

Cat.No: TN1691

Synonym: 光甘草酚,光甘草醇

Target: P450, NF-κB, NO Synthase, Acyltransferase

P-Hydroxyphenethyl trans-ferulate

Cat.No: TN2030

Synonym: 反式-阿魏酸对羟基苯乙酯

Target: 5-HT Receptor

trans-Nerolidol

Cat.No: T36473

Cat.No: T5853

Synonym: RFS 2000,鲁比特康,9-Nitrocamptothecin

Target: Topoisomerase

Cat.No: TN2086

Target: Antibacterial

2-Hydroxyanthraquinone

Cat.No: T36914

Target: Others

Thymohydroquinone

Cat.No: T35749

Synonym: Thymoquinol

Target: Antioxidant, Reactive Oxygen Species

Cat.No: T1737

Synonym: NPI 031L,三叶草,染料木素,金雀异黄酮

Target: Apoptosis, EGFR, Endogenous Metabolite, Autophagy

Cat.No: T37753

Target: Cysteine Protease, Antibacterial

4-(Dimethylamino)cinnamaldehyde

Cat.No: TN6657

Cyclobisdemethoxycurcumin

Cat.No: T82640

Hexacosyl (E)-ferulate

Cat.No: TMA0245

Target: Others

Cat.No: TMA2563

Target: Tyrosinase

Isoscoparin-2′′O-glucoside

Cat.No: TN1802

Synonym: 异金雀花素-2”-O-吡喃葡萄糖苷,Isoscoparin-2''-Beta-D-glucopyranoside

Target: Others

Cat.No: TN4602

Target: NOS

Coronalolide methyl ester

Cat.No: TN3705

Target: HIV Protease

17-hydroxy Venturicidin A

Cat.No: T36044

Cat.No: T13679

Target: ERK

27-p-Coumaroyloxyursolic acid

Cat.No: TN2834

Target: Others

10-O-Trans-p-methoxycinnamoylcatalpol

Cat.No: T83467

Cat.No: TN3921

Target: Antifection

Talaromycesone A

Cat.No: T38349

3'-O-Methylorobol

Cat.No: TN1265

Synonym: 3'-O-METHYLOROBOL,3'-O-甲基香豌豆苷元

Target: Others

Cat.No: TN4342

Target: Others

Anhydroepiophiobolin A

Cat.No: T37543

Deoxyfusapyrone

Cat.No: T38104

Cat.No: TN3704

Target: HIV Protease

Cat.No: T36513

3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone

Cat.No: TN5133

Target: HIV Protease, Topoisomerase

(19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol

Cat.No: T83578

Cat.No: TN3920

Target: Raf, Antifection

Cat.No: TN5880

Cat.No: T38015

Cat.No: TN4113

Target: Antifection

19-O-Acetylchaetoglobosin A

Cat.No: T35609

Cat.No: T83913

Cat.No: T36815

Methyl pyropheophorbide-a

Cat.No: T33492

Synonym: MPPa (Methyl pyropheophorbide-a),NSC267052,Pyropheophorbidea,MPPa,NSC-267052,NSC 267052

Antibiotic PF 1052

Cat.No: T38097

11-Oxoisomogroside V

Cat.No: T79965

Cat.No: TN5655

Cat.No: T36992

Cat.No: T37714

Cat.No: T36438

--------- 更多 ---------

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼