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43

抑制剂 & 化合物

32

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T5460	Mofezolac 莫苯唑酸,莫非佐酸	COX	Immunology/Inflammation; Neuroscience
	Mofezolac 是一种非甾体类抗炎药，可缓解疼痛并具有抗炎活性，抑制 COX-1和COX-2的IC50为 1.44 和 447 nM。
T8719	SC99	Apoptosis; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	SC99 是一种口服有效选择性STAT3抑制剂，靶向 JAK2-STAT3 途径，抑制血小板活化和聚集，有抗骨髓瘤和抗血栓活性。它结合在 JAK2 的 ATP 结合袋中，抑制 JAK2 和 STAT3 的磷酸化。
T23127	PD-161570 PD 161570	EGFR; FGFR; PDGFR; Src	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	PD-161570 是一种有效的 ATP 竞争性人 FGF-1 受体抑制剂，IC50 为 39.9 nM，Ki 为 42 nM。它还是骨形态发生蛋白 (BMPs) 和TGF-β信号抑制剂。它抑制PDGF 刺激的自磷酸化和FGF-1受体磷酸化，IC50分别为 450 和 622 nM。它抑制 PDGFR、EGFR 和 c-Src 酪氨酸激酶，IC50 值分别为 310、240 和 44 nM。
TQ0059	Ilorasertib ABT-348	VEGFR; FLT; c-RET; PDGFR; Aurora Kinase	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	Ilorasertib (ABT-348) 是一种 ATP 竞争性多靶点激酶抑制剂，可抑制 Aurora A、Aurora B 和Aurora C，IC50值为120 nM、7 nM 和1 nM。它还抑制 RET 酪氨酸激酶、PDGFRβ 和 Flt1，IC50为7 nM、3 nM 和 32 nM。
T2137	Ibudilast AV-411,KC-404,MN-166,异丁司特	PDE	Metabolism
	Ibudilast (MN-166) 是一种环腺苷酸磷酸二酯酶 (PDE) 抑制剂，具有抗血小板聚集作用。它能够抑制气管平滑肌收缩性，可用于研究哮喘。它可对抗活化小胶质细胞的神经毒性，可能是一种有效的神经保护和抗痴呆药物。
T35570	Chiauranib CS2164,西奥罗尼	c-Fms; VEGFR; FLT; PDGFR; c-Kit; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	Chiauranib 是一种针对肿瘤血管生成的多靶点抑制剂，具有强大的抗癌作用。 Chiauranib 有效抑制血管生成相关激酶（VEGFR1、VEGFR2、VEGFR3、PDGFRα 和 c-Kit）、有丝分裂相关激酶 Aurora B 和慢性炎症相关激酶 CSF1R，IC50 值范围为 1-9 nM。
T3608	Carbasalate calcium Rheomin,Omegin,Alcacyl,Iromin,卡巴匹林钙,Solupsan,Carbasalate Calcium	Platelet aggregation	Others
	Carbasalate calcium (Rheomin) 是抗炎和解热剂，可用于研究疼痛的缓解。
T26982	Cerebrocrast IOS 11212,IOS-11212,IOS11212	Others	Others
	Cerebrocrast (IOS-11212) 是具有抗炎和降血糖活性，促进大鼠肝脏线粒体中 H+ 和 Cl- 的共转运，阻断人血小板活化，可用于研究糖尿病。
T29097	VAS 3947 VA-S3947,VA S3947,VAS3947	Apoptosis; NADPH-oxidase	Apoptosis; Immunology/Inflammation
	VAS 3947 是一种特异的 NADPH 氧化酶 (NOX) 抑制剂。VAS 3947具有强大的抗血小板作用, 通过 UPR 激活，主要由于蛋白质聚集和错误折叠，独立于抗 NOX 活性诱导细胞凋亡。
T1002	Etodolac Ultradol,AY-24236,依托度酸,Etodolic acid,Lodine	Retinoid Receptor; COX	Immunology/Inflammation; Metabolism; Neuroscience
	Etodolac (AY-24236) 是一种吡喃羧酸和非甾体抗炎药，具有解热和镇痛活性，对 COX 的 IC50为53.5 nM。
T0080	Trapidil 唑嘧胺,乐可安,Rocornal,Trapymine,Avantrin,Trapymin,AR-12008	PDGFR; PDE	Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
	Trapidil (Avantrin) 是一种抗血小板药物，是一种血管扩张剂，有特异性血小板衍生生长因子。
T70084	Dersalazine Dersalazine Free Base	IL Receptor; Platelet aggregation	Immunology/Inflammation; Others
	Dersalazine (Dersalazine Free Base) 是血小板活化因子抑制剂，通过下调 IL-17表达，在不同啮齿动物型结肠炎中发挥肠道抗炎活性，对溃疡性结肠炎患者具有潜在疗效。
T77442	Glenzocimab ACT017	Others	Others
	Glenzocimab (ACT017) 是人源化抗 GPVI 单克隆抗体的 Fab 片段。Glenzocimab 在缺血性卒中模型对胶原诱导的血小板聚集显示出抑制作用。Glenzocimab 具有研究急性缺血性脑卒中和脑血栓。
T76844	Abciximab C7E3	Integrin	Cytoskeletal Signaling
	Abciximab (C7E3) 是一种小鼠/人嵌合单克隆抗体，是一种有效的糖蛋白 IIb/IIIa (glycoprotein IIb/IIIa) 抑制剂。 Abciximab 具有抗血小板聚集和白细胞粘附的作用，通过与糖蛋白 IIb/IIIa、vitronectin 和 Mac-1 受体结合发挥作用。
T0839	Ketoprofen 酮基布洛芬,RP-19583,酮洛芬	Apoptosis; COX; MRP	Apoptosis; Immunology/Inflammation; Neuroscience
	Ketoprofen (RP-19583) 是一种非甾体抗炎剂，能够有效地抑制COX 的活性，在人血单核细胞中，对 COX-1 和 COX-2 的IC50值分别为 2 nM 和 26 nM。
T74485	STC314	Others	Others
	STC314 具有抗感染作用，通过中和胞外组蛋白和中性粒细胞诱捕网来逆转机体过度免疫反应造成的器官损伤，可用于研究脓毒症和急性呼吸窘迫综合征(ARDS)。STC314 可保护脂质双层的稳定性，抑制血小板活化和红细胞损伤。
T3979	Emedastine LY188695,依美斯汀,Emadine	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Emedastine (LY188695) 是一种可口服的，选择性和高亲和力的组胺 H1受体拮抗剂，Ki 值为 1.3 nM。它是苯并咪唑衍生物，可用于过敏性鼻炎、过敏性皮肤疾病和过敏性结膜炎的研究。
T68025	Zoliprofen	Others	Others
	Zoliprofen 是一种一种高效的且可口服的非甾体抗炎剂，具有抗炎、解热和镇痛活性，对角叉菜素、制霉菌素、刀豆球蛋白A 诱导的大鼠爪水肿，以及抗大鼠兔血清诱导的骨折或背皮水肿具有抑制作用。Zoliprofen 在大鼠和兔子中对胶原蛋白或花生四烯酸引起的血小板聚集方面比布洛芬和非诺洛芬有效20倍。Zoliprofen 对小鼠内毒素诱导的腹泻和花生四烯酸诱导的兔急性死亡抑制作用显著。
T4978	Sarpogrelate hydrochloride 盐酸沙格雷酯,MCI-9042	5-HT Receptor	GPCR/G Protein; Neuroscience
	Sarpogrelate hydrochloride (MCI-9042) 是一种选择性5-HT2R 拮抗剂，可用于研究与血栓形成有关的血管疾病，对 5-HT2A、5-HT2B 和 5-HT2C 受体的pKi 值分别为 8.52、6.57 和 7.43。
T27370	FR106969 FR-106969,FR 106969
	FR106969 is a platelet activating factor antagonist isolated from fungus with anti-inflammatory activity.
T33395	Miroprofen Miroprofene,Antopen,Y 9213,Y-9213,Miroprofeno,Miroprofenum
	Miprofen is an analgesic and non-steroidal anti-inflammatory, which means it has anti-inflammatory, antipyretic, and anti-platelet aggregation activities.
T68237	Temanogrel hydrochloride
	Temanogrel hydrochloride is a serotonin antagonist and anti-platelet agent.
T23684	AHR-6293
	AHR-6293 is used to distinguishing the effect of anti-platelet aggregating drug properties and the effect of anti-inflammatory properties.
T32371	Kebuzone Chepirol,RN 0308507,Chebutan,Chetazolidin,Chetil
	Kebuzone is a non-steroidal anti-inflammatory drug, known to have analgesic, antipyretic, and platelet inhibitory activities.
T17101	Tiopinac 硫平酸,RS 40974	Others	Others
	Tiopinac 是一种三环化合物，对动物具有高效的抗炎、镇痛和解热作用，能够抑制前列腺素合成，对人类具有适度的抗血小板聚集特性。
T63334	Antiplatelet agent 1
	Antiplatelet agent 1 是一种替卡格雷 (Ticagrelor) 类似物，表现出抗血小板作用，能够用于血小板凝集的研究。
T63335	Antiplatelet agent 2
	Antiplatelet agent 2 是一种替卡格雷 (Ticagrelor) 类似物，表现出抗血小板作用，能够用于血小板凝集的研究。
T27638	Israpafant Y-24180,Y 24180,Y24180
	Israpafant is a selective antagonist for the platelet-activating factor receptor ( IC50 = 0.84nM). Israpafant inhibits PAF-induced human platelet aggregation. Israpafant inhibits the activation of eosinophil cells and consequently delays the development o
T26775	Bepafant WEB-2170,WEB2170,STY 2108,STY-2108,WEB 2170
	Bepafant is a platelet activating factor (PAF) antagonist. Bepafant may produce significant anti-inflammatory effects. Bepafant triggered apoptosis in NB4, KG1, and NB4-MR4 cells where PTEN was expressed, but not in THP1 and U937 cells where PTEN was abse
T36178	Aspalatone
	Aspalatone is an anti-platelet aggregator (IC50 = 180 μM, in vitro) that prolongs bleeding time significantly in a rodent model of thromboembolism. Additionally at a minimal effective dose of 24 mg/kg, aspalatone generates antioxidant and neuroprotective effects against kainic acid-induced epilepsy in rat hippocampus.
T35431	(±)-Clopidogrel (hydrochloride)
	Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active metabolite via CYP2C19 in the liver enables its anti-aggregating activity. Marketed under the name Plavix , clopidogrel in combination with aspirin has been shown to be beneficial in the prevention of vascu...
T78666	Egaptivon pegol ARC 1779	Integrin	Cytoskeletal Signaling
	Egaptivon pegol (ARC1779)为一种核酸适配体，能够阻断von Willebrand Factor (VWF)与血小板GPIb受体的结合，从而展现其抗血栓功能。
T75689	Mumefural
	Mumefural，Prunus mumeSieb 加工果实中的一种生物活性成分，具有抑制血小板聚集、显示抗血栓作用及改善认知障碍的功能。
T36112	Clopidogrel Carboxylic Acid (hydrochloride)
	Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active thiol metabolite via CYP2C19 in the liver enables its anti-aggregating activity. An estimated 15% of administered clopidogrel is metabolized by CYP2C19 to the thiol metabolite. Clopidogrel carboxylic acid i...
T68847	Aspirin calcium
	Aspirin calcium is the prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
T78283	Caplacizumab ALX-0081,ALX-0681
	Caplacizumab (ALX-0681)为人源化抗血管性血友病因子(vWF)纳米抗体，具有抑制vWF介导的血小板粘附作用，可阻止微血栓进一步形成。该化合物在血栓性血小板减少性紫癜（TTP）研究中应用。
T62872	PDGFR-IN-1
	PDGFR-IN-1 (compound 7m) 是一种口服具有活力的 PDGFR (血小板源性生长因子受体) 抑制剂，作用于 PDGFRα (IC50: 2.4 nM) 和 PDGFRβ (IC50: 0.9 nM)。。PDGFR-IN-1 表现出较强的抗肿瘤作用，并毒性较低，能够用于研究骨肉瘤。
T35600	NO-Losartan A
	Angiotensin II is a hormone that plays an important role in regulating blood pressure. Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor. Losartan is a mammalian AT1 receptor antagonist with a Ki value of 5-20 nM. In humans, losartan effectively controls hypertension while protecting renal function. Nitric oxide (NO) causes vasodi...
T62250	GPVI antagonist 2
	GPVI antagonist 2 (Compound 1) 是一种潜在的 Glycoprotein VI (GPVI) 拮抗剂，能够作用于胶原蛋白 (IC50: 0.35 μM)、CRP (IC50: 0.80 μM)、convulxin (IC50: 195.2 μM)、凝血酶 (IC50: 81.38 μM)。其中糖蛋白 VI (GPVI) 是一种血小板主要胶原受体，是有效的、安全的抗血栓研究靶点。GPVI antagonist 2 是一种很有前途的抗血小板药物。
T21547	PAF (C16) C16-PAF	ERK; MEK; MAPK; Endogenous Metabolite	MAPK; Metabolism
	PAF (C16) 是有效的 MAPK 和 MEK/ERK 激活剂，可诱导血管通透性增加。PAF (C16) (PAF (C16)) 是血小板活化因子，是一种磷脂衍生介质，也是 PAF G 蛋白偶联受体 (PAFR) 的配体。PAF (C16) 在体外实验中显示出抗凋亡和抗炎活性，通过与其受体（PAF-R）相互作用以执行细胞信号传导来抑制 caspase 依赖性凋亡。
T36618	Rupatadine
	Rupatadine (UR-12592) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM(rabbit platelet membranes/guinea pig cerebellum membranes).IC50 value:Target: PAF/H1 antagonistin vitro: Rupatadine competitively inhibited histamine-induced guinea pig ileum contraction (pA2 = 9.29 +/- 0.06) without affecting contraction induced by ACh, serotonin or leukotriene D4 (LTD4). It also competitively inhibited PAF-induced platelet aggregation in washed rabbit platelets (WRP) (pA2 = 6.68 +/- 0.08) and in hu...
T60979	Oxaprozin potassium
	Oxaprozin potassium 是具有口服活性的COX 的抑制剂，其对人血小板COX-1 的IC50值为 2.2 μM，对 IL-1 刺激的人类滑膜细胞COX-2的IC50值为 36 μM。Oxaprozin potassium 诱导细胞凋亡。Oxaprozin potassium 还抑制 NF-κB 活化，Oxaprozin potassium 介导的Akt/IKK/NF-κB 通路抑制有助于其抗炎特性。
T37488	10(S),17(S)-DiHDHA
	Protectin D1 (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities. 10(S),17(S)-DiHDHA is a DHA metabolite, also referred to as protectin DX (PDX). It is produced by an apparent double lipoxygenase (LO)-mediated reaction in murine peritonitis exudates, in suspensions of human leukocytes, or by soybean 15-LO incubated with DHA. It differs from protectin D1 with respect to the stere...

化合物

Cat.No: T5460

Synonym: 莫苯唑酸,莫非佐酸

Target: COX

Cat.No: T8719

Target: Apoptosis, JAK, STAT

Cat.No: T23127

Synonym: PD 161570

Target: EGFR, FGFR, PDGFR, Src

Cat.No: TQ0059

Synonym: ABT-348

Target: VEGFR, FLT, c-RET, PDGFR, Aurora Kinase

Cat.No: T2137

Synonym: AV-411,KC-404,MN-166,异丁司特

Target: PDE

Cat.No: T35570

Synonym: CS2164,西奥罗尼

Target: c-Fms, VEGFR, FLT, PDGFR, c-Kit, Aurora Kinase

Carbasalate calcium

Cat.No: T3608

Synonym: Rheomin,Omegin,Alcacyl,Iromin,卡巴匹林钙,Solupsan,Carbasalate Calcium

Target: Platelet aggregation

Cat.No: T26982

Synonym: IOS 11212,IOS-11212,IOS11212

Target: Others

Cat.No: T29097

Synonym: VA-S3947,VA S3947,VAS3947

Target: Apoptosis, NADPH-oxidase

Cat.No: T1002

Synonym: Ultradol,AY-24236,依托度酸,Etodolic acid,Lodine

Target: Retinoid Receptor, COX

Cat.No: T0080

Synonym: 唑嘧胺,乐可安,Rocornal,Trapymine,Avantrin,Trapymin,AR-12008

Target: PDGFR, PDE

Cat.No: T70084

Synonym: Dersalazine Free Base

Target: IL Receptor, Platelet aggregation

Cat.No: T77442

Synonym: ACT017

Target: Others

Cat.No: T76844

Synonym: C7E3

Target: Integrin

Cat.No: T0839

Synonym: 酮基布洛芬,RP-19583,酮洛芬

Target: Apoptosis, COX, MRP

Cat.No: T74485

Target: Others

Cat.No: T3979

Synonym: LY188695,依美斯汀,Emadine

Target: Histamine Receptor

Cat.No: T68025

Target: Others

Sarpogrelate hydrochloride

Cat.No: T4978

Synonym: 盐酸沙格雷酯,MCI-9042

Target: 5-HT Receptor

Cat.No: T27370

Synonym: FR-106969,FR 106969

Cat.No: T33395

Synonym: Miroprofene,Antopen,Y 9213,Y-9213,Miroprofeno,Miroprofenum

Temanogrel hydrochloride

Cat.No: T68237

Cat.No: T23684

Cat.No: T32371

Synonym: Chepirol,RN 0308507,Chebutan,Chetazolidin,Chetil

Cat.No: T17101

Synonym: 硫平酸,RS 40974

Target: Others

Antiplatelet agent 1

Cat.No: T63334

Antiplatelet agent 2

Cat.No: T63335

Cat.No: T27638

Synonym: Y-24180,Y 24180,Y24180

Cat.No: T26775

Synonym: WEB-2170,WEB2170,STY 2108,STY-2108,WEB 2170

Cat.No: T36178

(±)-Clopidogrel (hydrochloride)

Cat.No: T35431

Egaptivon pegol

Cat.No: T78666

Synonym: ARC 1779

Target: Integrin

Cat.No: T75689

Clopidogrel Carboxylic Acid (hydrochloride)

Cat.No: T36112

Aspirin calcium

Cat.No: T68847

Cat.No: T78283

Synonym: ALX-0081,ALX-0681

Cat.No: T62872

Cat.No: T35600

GPVI antagonist 2

Cat.No: T62250

Cat.No: T21547

Synonym: C16-PAF

Target: ERK, MEK, MAPK, Endogenous Metabolite

Cat.No: T36618

Oxaprozin potassium

Cat.No: T60979

10(S),17(S)-DiHDHA

Cat.No: T37488

Cat. No.	Product Name	Target	Signaling Pathways
TN2085	Piperlonguminine	Anti-infection; Antibacterial; Antifungal	Microbiology/Virology
	Piperlonguminine 是一种从 Piper 中分离出的生物碱酰胺。它具有多种生物活性，如神经保护、抗炎、抗肿瘤、抗血小板、抗黑素生成、抗真菌和抗菌活性。
T6S0139	Neobavaisoflavone	Apoptosis; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Neobavaisoflavone 是一种从Psoralea corylifolia 的种子中分离出来的类黄酮。它具有抗炎，抗癌和抗氧化的作用。它在中至高浓度下可抑制 DNA 聚合酶，也可抑制血小板聚集。
TN1969	N-(p-Coumaroyl) serotonin	PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	N-(p-Coumaroyl) Serotonin 是从红花种子中分离出来的多酚，具有抗氧化、抗动脉粥样硬化和抗炎作用，常用于动脉粥样硬化的研究。它可改善动脉粥样硬化和主动脉壁膨大。它可降低肌浆网中 PDGF 诱导的对中PDGFR 酪氨酸磷酸化和 Ca2+释放的作用。
TN1926	Methyl caffeate Methyl caffeate acid,金银花,咖啡酸甲酯	Others; Antibacterial	Microbiology/Virology; Others
	Methyl caffeate (Methyl caffeate acid) acid 是一种抗微生物剂，有抗菌和抗分枝杆菌活性。它还抑制 α-葡萄糖苷酶，有氧化应激抑制活性，抗血小板活性，子宫颈癌的抗增殖活性以及肺和白细胞的抗癌活性。
TN6924	Anhydrosafflor yellow B (2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1,脱水红花黄色素B,AHSYB	Others	Others
	Anhydrosafflor yellow B ((2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1) 是从红花中分离出来的，可抑制 ADP 诱导的血小板聚集，在体外表现出显着的抗氧化作用，并对 H2O2 诱导的细胞毒性具有一定的活性。
T2898	Andrographolide Andrographis,穿心莲内酯	SARS-CoV; Influenza Virus; NF-κB; Autophagy	Autophagy; Microbiology/Virology; NF-κB
	Andrographolide (Andrographis) 是 NF-κB 的不可逆拮抗剂，具有抗病毒、抗炎和抗血小板聚集活性和潜在的抗肿瘤作用。
TN1383	Timosaponin B III Anemarsaponin BIII,知母皂苷B3,知母皂苷BIII	Others; Platelet aggregation	Others
	Timosaponin B III (Anemarsaponin BIII) 是一种具有生物活性的甾体皂苷，从知母中分离出来。Timosaponin B III 具有抗炎、抗血小板聚集和抗抑郁作用。
T5S0896	Loureirin A 龙血素 A,龙血素A	Akt; PI3K	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Loureirin A 是一种黄酮类物质，从龙血树中分离得到，能够降低Akt 的磷酸化，具有抗血小板聚集作用。
T3S1591	Notoginsenoside Fc 三七皂苷 FC,三七皂苷Fc	Others; Autophagy	Autophagy; Others
	Notoginsenoside Fc 是从三七叶中分离得到的原卟啉二醇型皂苷，可通过促进自噬促进糖尿病大鼠血管损伤后的内皮细胞再生，具有抗血小板聚集的作用。
TN1622	Ermanin 堪非醇3,4'-二-O-甲醚	NOS; Influenza Virus; COX; HIV Protease; Antibacterial; Antibiotic	Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Ermanin 是一种从 Tanacetum microphyllum 中分离出来的类黄酮。Ermanin抑制血小板聚集，具有抗结核和抗病毒/细菌特性。Ermanin 可抑制 iNOS 和 COX-2 的表达，从而具有抗炎活性。Ermanin 可能具有抗 HIV-1 活性。Ermanin 在较低浓度下可有效地抑制 Dione juno 幼虫。
T2S1749	Protogracillin 原纤细薯蓣皂甙	Others	Others
	Protogracillin 是一种甾体皂苷，分离自Dioscorea zingiberensisWright (DZW) 中。从 DZW 根状茎中获得的甾体皂苷具有抗血栓作用，同时由降低心血管疾病风险的潜力。
T7030	anemarsaponin B 知母皂苷B,知母皂苷 B	p38 MAPK; NF-κB; MEK; COX; NO Synthase	Immunology/Inflammation; MAPK; Neuroscience; NF-κB
	Anemarsaponin B 是一种甾体皂苷，可降低iNOS 和COX-2的蛋白和 mRNA 水平，减少促炎细胞因子的表达和产生。它通过阻断 IκBα 的磷酸化来抑制NF-κB 的 p65 亚基的核转位，还抑制 MAP 激酶激酶 3/6 (MKK3/6) 和混合谱系激酶 3 的磷酸化。
T5S2358	Dehydrocorydaline Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine	BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome
	Dehydrocorydaline (13-Methylpalmatine) 是一种生物碱。它调节Bax，Bcl-2蛋白表达，激活caspase-7，caspase-8，并使PARP 失活。它能增强p38 MAPK 活化，具有抗炎、抗癌等功效。它具有强大的抗疟疾作用，并具低细胞毒性。
TN3964	Epiaschantin	Others	Others
	(+)-Epiaschantin shows marginal cancer cell line inhibitory activities. It also has anti-platelet aggregation activity.
TN1095	Ginsenoside Rk2 人参皂苷RK2	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Ginsenoside Rk1 has anti-tumor, and anti-platelet aggregation activities.
TN6472	Columbianetin beta-D-glucopyranoside
	Columbianetin-beta-D-glucopyranoside exhibits anti-inflammatory and analgesic properties, it also shows strong inhibiting activity against platelet aggregation.
TN4367	Kadsurin A	PAFR	GPCR/G Protein
	Kadsurin A 具有抗血小板活化因子活性。
TN1654	Futoquinol	Others; ROS; PAFR	GPCR/G Protein; Immunology/Inflammation; Others
	Futoquinol is an anti-platelet activating factor principle from the stem part of Piper futokadsura (Piperaceae), the Chinese drug haifengteng.
TN4797	Piperolactam C	PAFR; Antifection	GPCR/G Protein; Microbiology/Virology
	Piperolactam C possesses anti-platelet aggregation activity in vitro. It can inhibit the growth of the fungi Cladosporium sphaerospermum and C. cladosporioides.
TN6056	Zanthobungeanine 8-Methoxy-N-methylflindersine
	Zanthobungeanine has anti-inflammatory activity, it shows moderate NO production inhibitory activity with an IC50 value of 37.26 mg /L.It shows obviously inhibitoryactivity to platelet aggregation caused by platelet-activating factor (PAF). Zanthobungeani
TL0017	Aristolactam AIIIa	MAPK; CDK	Cell Cycle/Checkpoint; MAPK
	Aristolactam AIIIa is a new type of Plk1 inhibitors, targeting the Polo Box domain (PBD), it has anti-tumor activity. Aristolactam IIIa shows inhibition of platelet aggregation induced by collagen or arachidonic acid.
TN4795	Piperenone	PAFR	GPCR/G Protein
	Piperenone is an insect antifeeding substance. It has anti-platelet-activating factor(PAF) activities, is a PAF-acether antagonist.
TN3445	Aristolactam BIII	PAFR	GPCR/G Protein
	Aristolactam BIII possesses anti-platelet aggregation activity in vitro, it also shows significant cytotoxic activity (IC50 values < 4 microg/mL) against P-388, HT-29 and A549 cell lines in vitro.
TN3153	6-Acetyl-2,2-dimethylchroman-4-one	PAFR	GPCR/G Protein
	6-Acetyl-2,2-dimethylchroman-4-one and vanillin show anti-platelet aggregation activity induced by arachidonic acid in vitro.
T3734	3',4'-Dihydroxyacetophenone 二羟基苯乙酮,Qingxintong,4-Acetylpyrocatechol	Tyrosinase; Platelet aggregation	Others; Proteases/Proteasome
	3',4'-Dihydroxyacetophenone (Qingxintong) 是一种血管活性物质和抗氧化剂，可从Picea Schrenkiana 中分离得到，能抑制酪氨酸酶，其IC50=10 μM。
T3P2855	Chamigrenal	EGFR; NOS; PAFR; COX; Prostaglandin Receptor	Angiogenesis; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Tyrosine Kinase/Adaptors
	β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 macrophages. Chamigrenal shows platelet-activating factor antagonistic activity and the IC(50)
TN2106	Protodeltonin 原三角叶皂苷	BCL; PARP; Caspase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome
	Protodeltonin may have anti-thrombotic activity by both improving the anticoagulation activity and inhibiting platelet aggregation action. Protodeltonin can inhibit the proliferation of a panel of established human and murine cancer cell lines in vitro.
T79948	Kadsurenin B
	Kadsurenin B为PAF（platelet-activating factor）拮抗剂，展现出神经保护作用。该化合物在药理学领域显示出广泛的研究潜力，包括抗菌、抗炎、神经保护、抗氧化、抗血小板聚集、细胞毒性和抗寄生虫等效能。
TN3979	Epiyangambin	PAFR	GPCR/G Protein
	Epiyangambin is a phytotoxic lignan, it shows inhibition of seed germination of Agrostis stolonifera cv. penncross (Poaceae) and inhibition of development of Lactuca sativa L. (Asteraceae) seedlings in a microassay using 24-well plates. Epiyangambin exhibits significant inhibition of the transformation of murine epidermal JB6 cells, with the IC50 value of 0.15 microg/mL. (+)-Epiyangambin also has anti-platelet aggregation activity.
TN4382	Kazinol A	AMPK; mTOR	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Kazinol A shows strong inhibition of arachidonic acid (AA)-induced platelet aggregation. It also exhibits potent inhibition with IC50 values ranging 0.6-164 M against XOD. Kazinol A may be a candidate for the development of effective anti-cancer drug on h
TN5221	(-)-Variabilin
	Variabilin, a novel inhibitor of human platelet aggregation, it is a potent RGD (Arg-Gly-Asp)-containing antagonist of the fibrinogen receptor glycoprotein IIb-IIIa (GPIIb-IIIa; αIIbβ3) and the vitronectin receptor αvβ3.Variabilin is also an antimicrobial furanosesterterpene. Variabilin is an inhibitor of human secretory and cytosolic phospholipase A2 (PLA2) activities that controls eicosanoid production in vitro and in vivo, inhibits neutrophil degranulation and superoxide generation in vitro a...
T38330	Collinin
	Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a...

天然产物

Piperlonguminine

Cat.No: TN2085

Target: Anti-infection, Antibacterial, Antifungal

Neobavaisoflavone

Cat.No: T6S0139

Target: Apoptosis, DNA/RNA Synthesis

N-(p-Coumaroyl) serotonin

Cat.No: TN1969

Target: PDGFR

Methyl caffeate

Cat.No: TN1926

Synonym: Methyl caffeate acid,金银花,咖啡酸甲酯

Target: Others, Antibacterial

Anhydrosafflor yellow B

Cat.No: TN6924

Synonym: (2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1,脱水红花黄色素B,AHSYB

Target: Others

Andrographolide

Cat.No: T2898

Synonym: Andrographis,穿心莲内酯

Target: SARS-CoV, Influenza Virus, NF-κB, Autophagy

Timosaponin B III

Cat.No: TN1383

Synonym: Anemarsaponin BIII,知母皂苷B3,知母皂苷BIII

Target: Others, Platelet aggregation

Cat.No: T5S0896

Synonym: 龙血素 A,龙血素A

Target: Akt, PI3K

Notoginsenoside Fc

Cat.No: T3S1591

Synonym: 三七皂苷 FC,三七皂苷Fc

Target: Others, Autophagy

Cat.No: TN1622

Synonym: 堪非醇3,4'-二-O-甲醚

Target: NOS, Influenza Virus, COX, HIV Protease, Antibacterial, Antibiotic

Cat.No: T2S1749

Synonym: 原纤细薯蓣皂甙

Target: Others

anemarsaponin B

Cat.No: T7030

Synonym: 知母皂苷B,知母皂苷 B

Target: p38 MAPK, NF-κB, MEK, COX, NO Synthase

Dehydrocorydaline

Cat.No: T5S2358

Synonym: Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Cat.No: TN3964

Target: Others

Ginsenoside Rk2

Cat.No: TN1095

Synonym: 人参皂苷RK2

Target: VEGFR

Columbianetin beta-D-glucopyranoside

Cat.No: TN6472

Cat.No: TN4367

Target: PAFR

Cat.No: TN1654

Target: Others, ROS, PAFR

Cat.No: TN4797

Target: PAFR, Antifection

Zanthobungeanine

Cat.No: TN6056

Synonym: 8-Methoxy-N-methylflindersine

Aristolactam AIIIa

Cat.No: TL0017

Target: MAPK, CDK

Cat.No: TN4795

Target: PAFR

Aristolactam BIII

Cat.No: TN3445

Target: PAFR

6-Acetyl-2,2-dimethylchroman-4-one

Cat.No: TN3153

Target: PAFR

3',4'-Dihydroxyacetophenone

Cat.No: T3734

Synonym: 二羟基苯乙酮,Qingxintong,4-Acetylpyrocatechol

Target: Tyrosinase, Platelet aggregation

Cat.No: T3P2855

Target: EGFR, NOS, PAFR, COX, Prostaglandin Receptor

Cat.No: TN2106

Synonym: 原三角叶皂苷

Target: BCL, PARP, Caspase

Cat.No: T79948

Cat.No: TN3979

Target: PAFR

Cat.No: TN4382

Target: AMPK, mTOR

Cat.No: TN5221

Cat.No: T38330

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