首页工具

登录

搜索结果

Search Results for " site "

507

抑制剂 & 化合物

35

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T39185	pp60 (v-SRC) Autophosphorylation Site, Phosphorylated pp60 (v-SRC) Autophosphorylation Site, Phosphorylated
	pp60 (v-SRC) Autophosphorylation Site, Phosphorylated is a phosphorylated peptide derived from an EGFR substrate. It serves as a valuable tool for quantifying phosphorylated substrates in screening EGFR Kinase inhibitors.
T13342L	WIN site inhibitor 1 TFA (2407457-36-5 free base) WIN site inhibitor 1 TFA	Others	Others
	WIN site inhibitor 1 TFA is a WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5) inhibitor (Kd: 0.1 nM).
T83756	S1H TFA Site 1-binding Helix
	S1H是一种人造肽类模拟物，模仿人类生长激素的第36至51个氨基酸，且为生长激素受体的拮抗剂。在溶液中呈现α-螺旋结构，并在100和200纳摩尔（nM）的浓度下，能降低SK-MEL-28和MALME-3M黑色素瘤细胞系以及IM-9 B细胞淋巴细胞中，由人类生长激素及泌乳素诱导的STAT5磷酸化。
T13342	WDR5-IN-4 WIN site inhibitor 1	Others	Others
	WIN site inhibitor 1 is a WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5) inhibitor (Kd: 0.1 nM), with anti-cancer activity.
T8868	4BP-TQS	AChR	Neuroscience
	4BP-TQS 是 α7nAChR 变构激动剂。它利用变构跨膜位点激活 nAChRs。
T60072	ZL0590	Epigenetic Reader Domain	Chromatin/Epigenetic
	ZL0590 是一种有效的特异性 BD1-BRD4 抑制剂 (IC50 = 90 nM)，具有抗炎活性。
T76381	H1-7 (histone H1 phosphorylation site), PKA Substrate
	H1-7 (histone H1 phosphorylation site),PKASubstrate 是一种合成多肽，可作为PKA 底物。
T8230	PNU112455A hydrochloride PNU 112455A	CDK	Cell Cycle/Checkpoint
	PNU112455A hydrochloride 是 CDK2 和 CDK5 的 ATP 位点竞争性抑制剂，与 CDK2 和 CDK5 的 ATP 位点结合，Km 值为 3.6 和 3.2 μM。
T10066	2',5'-Dideoxyadenosine	Adenylyl cyclase; Adrenergic Receptor; AChR	GPCR/G Protein; Neuroscience
	2',5'-Dideoxyadenosine 是一种非竞争性腺苷酸环化酶抑制剂，通过结合 P 位点，IC50为 3 µM。它是核苷类似物，在心脏中发挥强大的抗肾上腺素作用。
T8533	ML318	Others; Antibiotic	Microbiology/Virology; Others
	ML318 是 PvdQ 酰基转移酶的联芳基腈抑制剂，可以结合在酰基结合位点上，IC50为 20 nM。它抑制铜绿假单胞菌的 IC50为 19 μM。它可防止嘧啶的产生并限制了铜绿假单胞菌在铁限制条件下的生长。
T41302	Itaconate-alkyne ITalk	Others	Others
	Itaconate-alkyne (ITalk) 是一种生物正交探针，用于对炎症性巨噬细胞中的衣康酸进行定量和位点特异性化学蛋白质组学分析，并能够对其直接靶标进行生化评估和蛋白质组学分析。
T15012	Crolibulin EPC2407	Microtubule Associated	Cytoskeletal Signaling
	Crolibulin (EPC2407) 是一种微管蛋白聚合抑制剂，具有诱导凋亡和抑制细胞生长的作用。它有抗肿瘤活性，还具有心血管毒性和神经毒性。
T8336	OGG1-IN-08 OGG1-IN-O8	Others	Others
	OGG1-IN-08 (OGG1-IN-O8) 是 8-氧鸟嘌呤 DNA 糖基酶-1 抑制剂(IC50:0.22 μM)。它能够减少 OGG1 的糖基化酶和裂解酶活性。
T38862	Nandrolone acetate 19-Nortestosterone 17β-acetate	Others	Others
	Nandrolone acetate (19-Nortestosterone 17β-acetate) 是一种甾体酮，是异构酶的竞争性抑制剂，对Δ5-3-酮甾体异构酶的 Ki 为 7 μM。
T9627	PHD-1-IN-1	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	PHD-1-IN-1 是口服有效的缺氧诱导因子脯氨酰羟化酶结构域 1抑制剂，IC50为 0.034 μM。它与活性位 Fe2+具有独特的单齿结合相互作用，并诱导形成一个 “Arg367-out” 口袋。
T1901	(E/Z)-TG003 TG003	BCL; CDK	Apoptosis; Cell Cycle/Checkpoint
	(E/Z)-TG003 是一种有效的 ATP 竞争性 Cdc2 样激酶 (Clk) 抑制剂，抑制 Clk1 和 Clk4 的 IC50值分别为 20 和 15 nM。它是 (Z)-TG003 和 (E)-TG003的消旋体。
T22517	5,7-Dichlorokynurenic acid 5,7-二氯犬尿喹啉酸,5,7-dichlorokynurenic acid sodium,5,7-DCKA	NMDAR	Neuroscience
	5,7-Dichlorokynurenic acid (5,7-dichlorokynurenic acid sodium) 是一种专门针对于NMDA 受体甘氨酸位点的竞争性拮抗剂(KB:65 nM)。它是犬尿酸的衍生物，可降低大鼠皮质细胞培养物中 NMDA 诱导的神经元损伤程度。
T1909	L-701324 7-氯-4-羟基-3-(3-苯氧基)苯基-2(1H)-喹啉,L701324	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	L-701324 是一种 NMDA 受体，对甘氨酸位点具有高亲和力和选择性，用作口服活性和长效抗惊厥药。
T11052L	Disitertide acetate P144 acetate,Disitertide acetate(272105-42-7 Free base)	TGF-beta/Smad	Stem Cells
	Disitertide acetate (P144 acetate) 是转化生长因子 TGFβ1 的多肽抑制剂，特异性的阻断其与受体间的相互作用。Disitertide acetate 也是PI3K 的抑制剂和凋亡 (apoptosis) 诱导剂。
T75716	Disitertide TFA
	Disitertide (P144) TFA 是转化生长因子TGFβ1的多肽抑制剂，特异性的阻断其与受体间的相互作用。Disitertide TFA 也是PI3K 的抑制剂和凋亡 (apoptosis) 诱导剂。
T75717	Disitertide diammonium
	Disitertide (P144) diammonium 是转化生长因子TGFβ1的多肽抑制剂，特异性的阻断其与受体间的相互作用。Disitertide diammonium 也是PI3K 的抑制剂和凋亡 (apoptosis) 诱导剂。
T124576	Petasitenine
	Petasitenine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124576。
T124496	4(15)-Oppositene-1,7-diol
	4(15)-Oppositene-1,7-diol 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124496。
T11052	Disitertide P144	Others	Others
	Disitertide (P144) is an inhibitor of TGF-β1.
T124565	Neopetasitenine
	Neopetasitenine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124565。
T13510	Sigma-LIGAND-1	Sigma receptor	GPCR/G Protein
	Sigma-LIGAND-1 是一种选择性 sigma 受体配体，在 DTG 和 PPP 位点的 IC50 分别为 16 nM，19 nM。Sigma-LIGAND-1 对多巴胺 D2 受体的 Ki 为 4000 nM。
T8864	Thymidylate Kinase Inhibitor, YMU1	Others	Others
	YMU1 是一种选择性抑制剂，特异性作用于人胸苷酸激酶 (IC50: 610 nM) 。
T63321	20S Proteasome activator 1	Proteasome	Proteases/Proteasome; Ubiquitination
	20S Proteasome activator 1 是一种 20S 蛋白酶激活剂，对胰蛋白酶样位点、胰凝乳蛋白酶样位点和半胱天冬酶位点的 IC50 分别为 0.3 μM、0.7 μM 和 1.8 μM。20S Proteasome activator 1 通过在细胞系统中翻译来防止致病性 α-synuclein A53T 突变体积累从而减少疾病发生的概率。20S Proteasome activator 1 可用于研究神经退行性疾病。
T26686	AV-101 L-4-Cl-KYN,L-4-chlorokynurenine,4-Cl-KYN,4ClKYN,4-Chlorokynurenine,(S)-4-Chlorokynurenine	NMDAR	Neuroscience
	AV-101 (4-Cl-KYN) 是 NMDA 受体甘氨酸位点的前药拮抗剂，具有抗抑郁活性，可减少 MPTP 猴子中左旋多巴诱导的运动障碍。
T4317	PF 429242	NPC1L1; Lipid	Membrane transporter/Ion channel; Metabolism
	PF 429242 是甾醇调节元件结合蛋白 (SREBP) 位点 1 蛋白酶的竞争性抑制剂 (IC50 = 0.175 μM)。它对位点 1 蛋白酶对一组丝氨酸蛋白酶具有选择性。 PF-429242 抑制 CHO 细胞中胆固醇的合成速率 (IC50 = 0.53 μM)。
T6152	PD318088	MEK	MAPK
	PD318088 是非 ATP 竞争性的MEK1/2变构抑制剂，是 PD184352 的结构类似物。它在MEK1 活性位点与 ATP 结合位点相邻的区域与 ATP 同时结合，可用于癌症研究。
T22542	1-Aminocyclobutanecarboxylic acid ACBC,1-氨基环丁烷羧酸	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	1-Aminocyclobutanecarboxylic acid (ACBC) 是一种NMDA 受体部分激动剂，作用于 NR1 甘氨酸位点。
T67887	BDCRB
	BDCRB 抑制疱疹病毒 DNA 成熟。 BDCRB 导致 HCMV 终止酶跳过正常的切割位点并继续包装 DNA，直到在多联体上 30 kb 处遇到第二个切割位点。
T16797	RPR104632	NMDAR	Neuroscience
	RPR104632 是一种新型有效的位于 NMDA 甘氨酸位点的拮抗剂，具有神经保护活性。
T21874	CID 2745687	GPR	Endocrinology/Hormones; GPCR/G Protein
	CID 2745687 是可逆的、特异性 GPR35竞争性拮抗剂（Ki:12.8 nM）。
T5819	Rapastinel Trifluoroacetate Thr-Pro-Pro-Thr-NH2 Trifluoroacetate,GLYX-13 Trifluoroacetate	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Rapastinel Trifluoroacetate (GLYX-13 Trifluoroacetate) 是一种 NMDA 受体调节剂，具有甘氨酸位点部分激动剂性质，有研究抑郁症的潜力。
T10493	Beclabuvir BMS-791325	Others	Others
	Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the HCV NS5B RNA-dependent RNA polymerase. It inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 (IC50 < 28 nM).
T14366	AZ10606120 dihydrochloride	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	AZ10606120 dihydrochloride 是一种可选择的、有效的、高亲和力的受体拮抗剂，在人和大鼠 P2X 7 受体上的 K D 值分别为 1.4 和 19 nM。AZ10606120 dihydrochloride 抑制肿瘤生长，具有抗血管生成活性。AZ 10606120在与 ATP 结合位点偶联的位点结合时充当负变构调节剂。
T3593	Src Inhibitor 1 Src Kinase Inhibitor 1,Src-l1	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	Src Inhibitor 1 (Src Kinase Inhibitor 1) 是一种选择性的、高效的、ATP-竞争性的双位点 Src 酪氨酸激酶抑制剂，能够抑制 Src (IC50:44 nM) 和 Lck (IC50:88 nM)。
TP2298L	transferrin fragment acetate	Others	Others
	transferrin fragment acetate 是动物血清中主要的铁结合蛋白，其铁结合位点和性质类似于乳铁蛋白1。
T24111	GSK3i XIII GSK3 inhibitor XIII,GSK3iXIII,GSK3i-XIII	GSK-3	PI3K/Akt/mTOR signaling; Stem Cells
	GSK3i XIII (GSK3 inhibitor XIII) 是ATP 竞争性GSK-3抑制剂(Ki: 24 nM)。
T9723	GluR6 antagonist-1	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	GluR6 antagonist-1 抑制酪氨酸激酶 p56lck SH2 结构域的 pY 结合位点。
T11516	GV-196771A	NMDAR	Neuroscience
	GV-196771A 一种新型的NMDA受体甘氨酸位点拮抗剂，具有强大的抗痛觉过敏活性。
TP2289L	RR-src acetate RR-src acetate(81156-93-6 Free base)	Others	Others
	RR-src acetate 是一种合成肽，来源于 pp60src 中磷酸化位点周围的氨基酸序列。
T15948	MAFP Methyl Arachidonyl Fluorophosphonate	Phospholipase	Metabolism
	MAFP (Methyl Arachidonyl Fluorophosphonate) (Methyl Arachidonyl Fluorophosphonate) 是选择性，针对活性位点，不可逆的 cPLA2 和 iPLA2 抑制剂。 MAFP 也是一种有效的不可逆的 anandamide amidase 抑制剂。
T21807	INCA-6 Triptycene-1,4-quinone	Others	Others
	INCA-6 (Triptycene-1,4-quinone) 是细胞渗透性的 NFAT 抑制剂。INCA-6 通过特异性阻断 NFAT 底物靶向钙调神经磷酸酶位点，有效抑制calcineurin (CN)-NFAT 信号传导。
T26408	A 21960 Ethyl 2-chloroacetoacetate,A21960,A-21960
	A 21960 (Ethyl 2-chloroacetoacetate) 能抑制 resolvase 与两个直接重复的 res 位点之间的突触形成，阻断位点特异性重组反应，可用于研究细菌感染。
T22798	Gavestinel GV 150526,Gavestinel sodium salt	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Gavestinel (GV 150526) 是一种非竞争性的 NMDA 受体拮抗剂，具有有效性、选择性和口服活性。Gavestinel 可与 NMDA 受体的甘氨酸位点结合，其结合亲和力(pKi 值)为 8.5。Gavestinel 可用于急性缺血性脑卒中研究。
T22051	BU 224 hydrochloride	Imidazoline Receptor	Neuroscience
	BU 224 hydrochloride 是一种选择性的咪唑啉 I(2) 结合位点配体，具有镇痛和抗抑郁样活性。
T5477	ELQ-300	Parasite	Microbiology/Virology
	ELQ-300 是一种有口服生物活性的抗疟疾剂，可作为细胞色素 bc1 复合物的还原位点的抑制剂

化合物

pp60 (v-SRC) Autophosphorylation Site, Phosphorylated

Cat.No: T39185

Synonym: pp60 (v-SRC) Autophosphorylation Site, Phosphorylated

WIN site inhibitor 1 TFA (2407457-36-5 free base)

Cat.No: T13342L

Synonym: WIN site inhibitor 1 TFA

Target: Others

Cat.No: T83756

Synonym: Site 1-binding Helix

Cat.No: T13342

Synonym: WIN site inhibitor 1

Target: Others

Cat.No: T8868

Target: AChR

Cat.No: T60072

Target: Epigenetic Reader Domain

H1-7 (histone H1 phosphorylation site), PKA Substrate

Cat.No: T76381

PNU112455A hydrochloride

Cat.No: T8230

Synonym: PNU 112455A

Target: CDK

2',5'-Dideoxyadenosine

Cat.No: T10066

Target: Adenylyl cyclase, Adrenergic Receptor, AChR

Cat.No: T8533

Target: Others, Antibiotic

Itaconate-alkyne

Cat.No: T41302

Synonym: ITalk

Target: Others

Cat.No: T15012

Synonym: EPC2407

Target: Microtubule Associated

Cat.No: T8336

Synonym: OGG1-IN-O8

Target: Others

Nandrolone acetate

Cat.No: T38862

Synonym: 19-Nortestosterone 17β-acetate

Target: Others

Cat.No: T9627

Target: HIF/HIF Prolyl-Hydroxylase

Cat.No: T1901

Synonym: TG003

Target: BCL, CDK

5,7-Dichlorokynurenic acid

Cat.No: T22517

Synonym: 5,7-二氯犬尿喹啉酸,5,7-dichlorokynurenic acid sodium,5,7-DCKA

Target: NMDAR

Cat.No: T1909

Synonym: 7-氯-4-羟基-3-(3-苯氧基)苯基-2(1H)-喹啉,L701324

Target: NMDAR, iGluR

Disitertide acetate

Cat.No: T11052L

Synonym: P144 acetate,Disitertide acetate(272105-42-7 Free base)

Target: TGF-beta/Smad

Disitertide TFA

Cat.No: T75716

Disitertide diammonium

Cat.No: T75717

Cat.No: T124576

4(15)-Oppositene-1,7-diol

Cat.No: T124496

Cat.No: T11052

Synonym: P144

Target: Others

Neopetasitenine

Cat.No: T124565

Cat.No: T13510

Target: Sigma receptor

Thymidylate Kinase Inhibitor, YMU1

Cat.No: T8864

Target: Others

20S Proteasome activator 1

Cat.No: T63321

Target: Proteasome

Cat.No: T26686

Synonym: L-4-Cl-KYN,L-4-chlorokynurenine,4-Cl-KYN,4ClKYN,4-Chlorokynurenine,(S)-4-Chlorokynurenine

Target: NMDAR

Cat.No: T4317

Target: NPC1L1, Lipid

Cat.No: T6152

Target: MEK

1-Aminocyclobutanecarboxylic acid

Cat.No: T22542

Synonym: ACBC,1-氨基环丁烷羧酸

Target: NMDAR, iGluR

Cat.No: T67887

Cat.No: T16797

Target: NMDAR

Cat.No: T21874

Target: GPR

Rapastinel Trifluoroacetate

Cat.No: T5819

Synonym: Thr-Pro-Pro-Thr-NH2 Trifluoroacetate,GLYX-13 Trifluoroacetate

Target: NMDAR, iGluR

Cat.No: T10493

Synonym: BMS-791325

Target: Others

AZ10606120 dihydrochloride

Cat.No: T14366

Target: P2X Receptor

Src Inhibitor 1

Cat.No: T3593

Synonym: Src Kinase Inhibitor 1,Src-l1

Target: Src

transferrin fragment acetate

Cat.No: TP2298L

Target: Others

Cat.No: T24111

Synonym: GSK3 inhibitor XIII,GSK3iXIII,GSK3i-XIII

Target: GSK-3

GluR6 antagonist-1

Cat.No: T9723

Target: Src

Cat.No: T11516

Target: NMDAR

Cat.No: TP2289L

Synonym: RR-src acetate(81156-93-6 Free base)

Target: Others

Cat.No: T15948

Synonym: Methyl Arachidonyl Fluorophosphonate

Target: Phospholipase

Cat.No: T21807

Synonym: Triptycene-1,4-quinone

Target: Others

Cat.No: T26408

Synonym: Ethyl 2-chloroacetoacetate,A21960,A-21960

Cat.No: T22798

Synonym: GV 150526,Gavestinel sodium salt

Target: NMDAR, iGluR

BU 224 hydrochloride

Cat.No: T22051

Target: Imidazoline Receptor

Cat.No: T5477

Target: Parasite

Cat. No.	Product Name	Target	Signaling Pathways
T11351	Galanthamine N-Oxide	AChE	Neuroscience
	Galanthamine N-Oxide 是分离于Zephyranthes concolor 的球茎中的一种生物碱。它抑制电鳗乙酰胆碱酯酶，EC50=26.2 μM。它是TcAChE，hAChE 和 hBChE 酶活性位点中底物调节的显著抑制剂。
T21065	Artemisitene	Others	Others
	Artemisitene 是青蒿素的氧化形式，是一种抗疟药。青蒿素前体是青蒿素生物合成的重要基础物质，包括青蒿素 B、青蒿素、青蒿酸等。
T20585	3-Acetylindole 3-乙酰吲哚,Acetyl-3-indole,3-Acetyl-1H-indole,3-Acetylindole	Others	Others
	3-Acetylindole (3-Acetyl-1H-indole) 可用作取代基和 Sudlow 位点 II 的 L-色氨酸的探针。
T5855	Edrophonium chloride	AChE	Neuroscience
	Edrophonium chloride 是一种乙酰胆碱酯酶抑制剂，可通过特异性结合其催化位点来防止神经递质乙酰胆碱的分解。
T10191L	7-Chlorokynurenic acid 7-chloro-4-hydroxy-2-carboxyquinoline,7-氯犬尿酸,7-CKA	GluR; NMDAR	Neuroscience
	7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) 是一种有效的选择性 NMDA 受体拮抗剂，对甘氨酸 B 激动剂位点的 IC50 为 0.56 μM。 7-Chlorokynurenic acid 抑制谷氨酸再摄取到突触小泡中，Ki 为 0.59 μM，并在神经轴输送后显示出镇痛作用。
TQ0119	Cirsimaritin	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Cirsimaritin 具有抗菌、抗炎、抗肿瘤、抗氧化特性和肾脏保护作用。 Cirsimaritin 与 GABAA 受体上的苯二氮卓位点结合较弱。
T5S0273	Hypaphorine Lenticin,Glyyunnanenine,Tryptophan Betaine,刺桐碱	Others	Others
	Hypaphorine (Lenticin) 是一种提取自 Pisolithus tinctorius 中的吲哚类生物碱，对啮齿动物具有有神经学影响降糖活性。
T3318	Wogonoside 汉黄芩苷,Glychionide B,Wogonin 7-O-glucuronide,Oroxindin	GABA Receptor; Autophagy	Autophagy; Membrane transporter/Ion channel; Neuroscience
	Wogonoside (Wogonin 7-O-glucuronide) 是从黄芩中分离得到的一种黄酮类天然产物，具有抗炎作用。它是 GABAA 受体苯二氮卓位点的正变构调节剂，可通过调节 MAPK-mTOR 通路诱导乳腺癌细胞的自噬。
TN2190	Scoulerine	Apoptosis; Beta-Secretase; BACE; Parasite	Apoptosis; Microbiology/Virology; Neuroscience
	Scoulerine 是抗有丝分裂化合物。它抑制细胞增殖，阻止细胞周期，并诱导癌细胞凋亡。它也是BACE1(淀粉样前体蛋白裂解酶 1) 的抑制剂。
T21351	Maytansine NSC-153858,NSC153858,Maitansina,NSC 153858,Maitansine,美坦新	Microtubule Associated; Antibiotic	Cytoskeletal Signaling; Microbiology/Virology
	Maytansine (NSC-153858) 是从变叶美登木中分离的一种高效微管靶向天然产物，可诱导有丝分裂阻滞并在亚纳摩尔浓度杀死肿瘤细胞。
TN1325	(2S)-6-Prenylnaringenin (2S)-6-异戊烯基柚皮素,6-异戊二烯基柚皮素,6-Prenylnaringenin,6-PN	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	(2S)-6-Prenylnaringenin (6-Prenylnaringenin) 是强效植物雌激素 8-prenylnaringenin 的异构体，是前脑中最有效的化合物，在 α+β 结合位点上起GABAA 正变构调节剂的作用。
TN1202	(-)-α-Pinene 左旋-α-蒎烯,左旋-alpha-蒎烯,(1S)-(-)-Alpha-Pinene	Virus Protease; GABA Receptor; Endogenous Metabolite; Antibacterial	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	(-)-α-Pinene ((1S)-(-)-Alpha-Pinene) 是一种单萜类化合物，通过延长 GABAergic 突触传递、作为 GABAA-BZD 受体的部分调节剂并直接与 GABAA 受体的 BZD 结合位点结合来增强 NREMS 的数量而不影响 NREMS 的强度。
T2O2730	L-Serine (S)-Serine,L-丝氨酸,丝氨酸,serine,(-)-Serine,(S)-2-Amino-3-hydroxypropanoic acid	Endogenous Metabolite	Metabolism
	L-Serine (serine) 是一种人体非必需氨基酸，它存在于许多蛋白质中，并且在功能上很重要。L-Serine 也存在于丝氨酸蛋白酶类的活性位点，包括胰蛋白酶和凝乳胰蛋白酶。
T1165	Ethionamide Bayer 5312,乙硫异烟胺,2-ethylthioisonicotinamide,Ethinamide	Dehydrogenase; CAT; Antibacterial; Antibiotic	Metabolism; Microbiology/Virology; oxidation-reduction
	Ethionamide (2-ethylthioisonicotinamide) 是一种抗结核抗生素。
TCS0102	Pulegone 胡薄荷酮,(+)-Pulegone,蒲勒酮，胡薄荷酮，长叶薄荷酮	Calcium Channel; Endogenous Metabolite; TRP/TRPV Channel	Membrane transporter/Ion channel; Metabolism
	Pulegone ((+)-Pulegone) 是 Calamintha nepeta (L.) Savi 的精油的主要化学成分，也是禽类驱虫剂之一。它在禽类物种中驱避作用的分子靶点是伤害感受性 TRP 锚蛋 1。它刺激鸡感觉神经元中的 TRPM8 和 TRPA1 通道，并在高浓度下抑制前者但不抑制后者。
T5243	(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate DMPE,1,2-十四酰基磷脂酰乙醇胺,1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine,1,2-Dimyristoyl-sn-glycero-3-PE	Others; Endogenous Metabolite	Metabolism; Others
	(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate (DMPE) 是内源性代谢产物的一种。
TN6722	Terminolic acid 2α,6β,23-trihydroxyl oleanolic acid	Antibacterial	Microbiology/Virology
	Terminolic acid (2α,6β,23-trihydroxyl oleanolic acid) 是一种从 Combretum racemosum 中分离得到的五环三萜糖苷，可通过与 IL-1β 和 IL-6 的受体活性位点结合抑制促炎细胞因子，并通过与 IL-4 受体结合位点结合增强抗炎细胞因子。它还表现出适度的抗菌活性。
T38108	Fulvic Acid	Antioxidant; PDE	Metabolism; oxidation-reduction
	Fulvic Acid 是一种来自土壤、沉积物或水生环境中微生物产生的腐殖质的天然产物，是一种首次青霉菌中分离出的酚酸和真菌代谢产物。Fulvic Acid 抑制淀粉样蛋白b (17-42) (AB17-42)二聚化，破坏预先形成的AB17-42三聚体，并结合到磷酸二酯酶5A (PDE5A)的催化位点，可以调节机体免疫系统，影响细胞的氧化状态，改善胃肠功能。Fulvic Acid 可作为氧化剂或还原剂，具有研究糖尿病等慢性炎症性疾病的潜力。
T22583	Arcaine sulfate	NMDAR	Neuroscience
	Arcaine sulfate 是一种多胺，是 N-甲基-d-天冬氨酸 (NMDA) 受体多胺结合位点的拮抗剂。 Arcaine 是一种胍丁胺类似物，与 ifenprodil 一起，可能有可能用于治疗癫痫疾病。
T3S0804	Worenine 甲基黄连碱,Worenin	Others	Others
	Worenine (Worenin) 是一种从黄连中提取的物质。它在大鼠体内第一阶段代谢中显示出脱氢，氢化，羟基化和脱亚甲基反应。在大鼠体内 II 期代谢中显示为硫酸化和葡萄糖醛酸化反应。
T10609	Brevetoxin-3 PbTx-3	Others	Others
	Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na+ channel activator. Brevetoxin-3 has a high affinity to site 5 of the voltage-sensitive Na+ channels, inhibits the inactivation of Na+ channels.
T79947	10-Hydroxyaloin A	SARS-CoV	Microbiology/Virology
	10-Hydroxyaloin A有效抑制SARS-CoV-2，与SARS-CoV-2 Mpro活性位点显著结合。
TN4552	Methyl p-hydroxyphenyllactate	Others	Others
	Methyl para-hydroxyphenyllactate(MeHPLA) can suppress the cellular proliferation of estrogen-sensitive MCF-7 breast cancer cells in vitro and to suppress the growth of rat uteri in vivo, high affinity of MeHPLA for the type II estrogen binding site (EBS)
TN4731	Pachyaximine A	Antifection	Microbiology/Virology
	Pachyaximine A possesses significant antibacterial activity against Escherichia coli, Staphylococcus aureus, Corynebacterium diphtheriae and Corynebacterium pyrogenes. (-)-Pachyaximine A demonstrates significant activity as antiestrogen binding site (AEBS
TN4088	Futoenone	PAFR	GPCR/G Protein
	Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate the preferred binding of the P2' site of the enzymes. Neolignan derivative compounds of the 2,4-diaryl-1,3-dithiolane and futoenone variety exhibit both platelet activating factor receptor(PAF)and 5-lipoxygenase antagonist activity.
T4752	1-Aminocyclopropane-1-carboxylic acid 1-Aminocyclopropanecarboxylic acid,1-氨基环丙烷羧酸,1-Amino-1-carboxycyclopropane,ACC	Endogenous Metabolite; NMDAR	Metabolism; Neuroscience
	1-Aminocyclopropane-1-carboxylic acid (ACC) 是内源性代谢产物的一种。
T4454	Traumatic Acid Dodec-2-Enedioic Acid,2E-Dodecenedioic Acid,愈伤酸,Trans-2-Dodecenedioic Acid	Antioxidant	oxidation-reduction
	Traumatic Acid (Dodec-2-Enedioic Acid) 是一种单不饱和二元羧酸，从菜豆中分离得到。它可减少膜磷脂的过氧化，并表现出抗氧化和对胶原生物合成的刺激作用。它可用于许多与胶原蛋白生物合成障碍和氧化应激有关的皮肤疾病的研究。
T39071	Thailanstatin D
	Thailanstatin D, an analogue of Thailanstatin A, inhibits AR-V7 gene splicing by disrupting the interaction between U2AF65 and SAP155, hindering their binding to the polypyrimidine tract situated between the branch point and the 3' splice site. This compound displays potent tumor inhibitory properties in human castration-resistant prostate cancer (CRPC) xenografts, resulting in cellular apoptosis.
TN1104	Cyanidin 3-sambubioside chloride 矢车菊素-3-桑布双糖苷,Cyanidin-3-O-sambubioside chloride	NF-κB; ROS	Immunology/Inflammation; NF-κB
	Cyanidin-3-O-sambubioside chloride is inhibitors of BPDE-induced NF-kB activity. It inhibits the enzyme activity by competing with the substrate for the active site. Cyanidin-3-O-sambubioside chloride has antioxidant activity and free-radical-scavenging p
T72172	4,6-O-Ethylidene-α-D-glucose Ethylidene-glucose
	4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose) 是一种葡萄糖衍生物，是竞争性的葡萄糖转运蛋白 1 (GLUT1) 面部结合部位抑制剂，对野生型 2-脱氧-D-葡萄糖转运的 Ki 值为 12 mM。
T36068	Brevetoxin B
	Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.
TN4505	Masticadienolic acid	Others	Others
	Masticadienolic acid is a specific competitive inhibitor of secreted phospholipase A2, it not only protects the active site histidine from alkylation but also inhibits the action of secreted from pancreas, synovial fluid, and bee venom. Masticadienolic ac
TN3472	Axillaridine A	Others	Others
	Axillaridine A is a new cholinesterase inhibitors, it may act as potential leads in the discovery of clinically useful inhibitors for nervous-system disorders, particularly by reducing memory deficiency in Alzheimer's disease patients by potentiating and
TN4399	Kushenol C	SGLT; NF-κB; ROS; BACE; Antifection	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB
	Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). Kushenol C shows antimicrobial activity against Staphylococcus aureus and Streptococcus mutan
T1104	Paromomycin Sulfate Aminosidine sulfate,Paromomycin sulfate salt,硫酸巴龙霉素,巴龙霉素硫酸盐	Antibacterial; Antibiotic; Parasite	Microbiology/Virology
	Paromomycin Sulfate (Aminosidine sulfate) 是一种广谱氨基糖苷类抗生素，是具有杀螨杀菌作用的新霉素衍生物。它通过与细菌 30S 核糖体 A 位点的 RNA 寡核苷酸特异性结合，使 mRNA 的翻译提前终止，并抑制蛋白质合成。它可研究细菌和寄生虫感染。

天然产物

Galanthamine N-Oxide

Cat.No: T11351

Target: AChE

Cat.No: T21065

Target: Others

Cat.No: T20585

Synonym: 3-乙酰吲哚,Acetyl-3-indole,3-Acetyl-1H-indole,3-Acetylindole

Target: Others

Edrophonium chloride

Cat.No: T5855

Target: AChE

7-Chlorokynurenic acid

Cat.No: T10191L

Synonym: 7-chloro-4-hydroxy-2-carboxyquinoline,7-氯犬尿酸,7-CKA

Target: GluR, NMDAR

Cat.No: TQ0119

Target: GABA Receptor

Cat.No: T5S0273

Synonym: Lenticin,Glyyunnanenine,Tryptophan Betaine,刺桐碱

Target: Others

Cat.No: T3318

Synonym: 汉黄芩苷,Glychionide B,Wogonin 7-O-glucuronide,Oroxindin

Target: GABA Receptor, Autophagy

Cat.No: TN2190

Target: Apoptosis, Beta-Secretase, BACE, Parasite

Cat.No: T21351

Synonym: NSC-153858,NSC153858,Maitansina,NSC 153858,Maitansine,美坦新

Target: Microtubule Associated, Antibiotic

(2S)-6-Prenylnaringenin

Cat.No: TN1325

Synonym: (2S)-6-异戊烯基柚皮素,6-异戊二烯基柚皮素,6-Prenylnaringenin,6-PN

Target: GABA Receptor

Cat.No: TN1202

Synonym: 左旋-α-蒎烯,左旋-alpha-蒎烯,(1S)-(-)-Alpha-Pinene

Target: Virus Protease, GABA Receptor, Endogenous Metabolite, Antibacterial

Cat.No: T2O2730

Synonym: (S)-Serine,L-丝氨酸,丝氨酸,serine,(-)-Serine,(S)-2-Amino-3-hydroxypropanoic acid

Target: Endogenous Metabolite

Cat.No: T1165

Synonym: Bayer 5312,乙硫异烟胺,2-ethylthioisonicotinamide,Ethinamide

Target: Dehydrogenase, CAT, Antibacterial, Antibiotic

Cat.No: TCS0102

Synonym: 胡薄荷酮,(+)-Pulegone,蒲勒酮，胡薄荷酮，长叶薄荷酮

Target: Calcium Channel, Endogenous Metabolite, TRP/TRPV Channel

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate

Cat.No: T5243

Synonym: DMPE,1,2-十四酰基磷脂酰乙醇胺,1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine,1,2-Dimyristoyl-sn-glycero-3-PE

Target: Others, Endogenous Metabolite

Terminolic acid

Cat.No: TN6722

Synonym: 2α,6β,23-trihydroxyl oleanolic acid

Target: Antibacterial

Cat.No: T38108

Target: Antioxidant, PDE

Arcaine sulfate

Cat.No: T22583

Target: NMDAR

Cat.No: T3S0804

Synonym: 甲基黄连碱,Worenin

Target: Others

Cat.No: T10609

Synonym: PbTx-3

Target: Others

10-Hydroxyaloin A

Cat.No: T79947

Target: SARS-CoV

Methyl p-hydroxyphenyllactate

Cat.No: TN4552

Target: Others

Cat.No: TN4731

Target: Antifection

Cat.No: TN4088

Target: PAFR

1-Aminocyclopropane-1-carboxylic acid

Cat.No: T4752

Synonym: 1-Aminocyclopropanecarboxylic acid,1-氨基环丙烷羧酸,1-Amino-1-carboxycyclopropane,ACC

Target: Endogenous Metabolite, NMDAR

Cat.No: T4454

Synonym: Dodec-2-Enedioic Acid,2E-Dodecenedioic Acid,愈伤酸,Trans-2-Dodecenedioic Acid

Target: Antioxidant

Thailanstatin D

Cat.No: T39071

Cyanidin 3-sambubioside chloride

Cat.No: TN1104

Synonym: 矢车菊素-3-桑布双糖苷,Cyanidin-3-O-sambubioside chloride

Target: NF-κB, ROS

4,6-O-Ethylidene-α-D-glucose

Cat.No: T72172

Synonym: Ethylidene-glucose

Cat.No: T36068

Masticadienolic acid

Cat.No: TN4505

Target: Others

Cat.No: TN3472

Target: Others

Cat.No: TN4399

Target: SGLT, NF-κB, ROS, BACE, Antifection

Paromomycin Sulfate

Cat.No: T1104

Synonym: Aminosidine sulfate,Paromomycin sulfate salt,硫酸巴龙霉素,巴龙霉素硫酸盐

Target: Antibacterial, Antibiotic, Parasite

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼