Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1-Aminocyclopropane-1-carboxylic acid (ACC) 是内源性代谢产物的一种。
产品描述 | 1-Aminocyclopropane-1-carboxylic acid (ACC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence. It is a small molecule agonist at the glycine modulatory site of the NMDA receptor (EC50 = 0.7-0.9 μM) in the presence of low levels (1 μM) of glutamate and as a competitive antagonist at the glutamate-binding site on NMDA receptors (EC50 = 81.6 nM) with high levels (10 μM) of glutamate.2 This compound has been reported to protect against neuron cell death in vivo models of ischemia by enabling moderate levels of NMDA receptor activation and attenuating any excess NMDA receptor signaling that may lead to neurotoxicity. |
靶点活性 | NMDAR:0.7-0.9 µM (EC50) |
体内活性 | The extracellular DA metabolite 3-Methoxytyramine hydrochloride (3-MT) induces significant behavioral activation in DDD mice. This activity, however, is mostly presented as a set of disorganized abnormal movements that include tremor, head bobbing, straub tail, grooming and abnormal orofacial movements rather than normal forward activity. No effect is observed when 3-Methoxytyramine hydrochloride is infused at doses below 9 μg, at 9 μg and higher doses 3-Methoxytyramine hydrochloride dose-dependently causes transient behavioral activation with a complex set of behaviors. In particular, transient hyperactivity and stereotypy, sniffing, grooming, rearing and mild abnormal involuntary movements (AIMs) at the level of limbs is observed after infusion of 9 μg of 3-Methoxytyramine hydrochloride. Similar behaviors are also observed after 18 μg of 3-Methoxytyramine hydrochloride with the additional appearance of tremor as well as oral and whole body AIMs[1]. |
别名 | 1-Aminocyclopropanecarboxylic acid, 1-氨基环丙烷羧酸, 1-Amino-1-carboxycyclopropane, ACC |
分子量 | 101.1 |
分子式 | C4H7NO2 |
CAS No. | 22059-21-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 10 mM
DMSO: Insoluble
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 9.8912 mL | 49.456 mL | 98.912 mL | 247.2799 mL |
5 mM | 1.9782 mL | 9.8912 mL | 19.7824 mL | 49.456 mL | |
10 mM | 0.9891 mL | 4.9456 mL | 9.8912 mL | 24.728 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
1-Aminocyclopropane-1-carboxylic acid 22059-21-8 Metabolism Neuroscience Endogenous Metabolite NMDAR 1-Aminocyclopropanecarboxylic acid 1 Aminocyclopropane 1 carboxylic acid 1-氨基环丙烷羧酸 1Aminocyclopropane1carboxylic acid inhibit 1-Amino-1-carboxycyclopropane ACC Inhibitor inhibitor