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Search Results for " oxidative-antioxidant "

31

抑制剂 & 化合物

42

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0412	Idebenone 艾地苯醌,CV-2619	Apoptosis; Antioxidant; Mitochondrial Metabolism	Apoptosis; Metabolism; oxidation-reduction
	Idebenone (CV-2619) 是一种线粒体保护剂，具有神经保护功效，可用于研究阿尔茨海默病、亨廷顿舞蹈病，可透过血脑屏障，诱导细胞凋亡。
T1487	Fluvastatin sodium XU 62320 sodium,XU-62-320,氟伐他汀钠,Fluvastatin sodium salt	Ferroptosis; HMG-CoA Reductase; Autophagy	Apoptosis; Autophagy; Metabolism
	Fluvastatin sodium (Fluvastatin sodium salt) salt 是羟甲基戊二酰辅酶 A 还原酶的竞争性抑制剂，IC50为 8 nM。它通过依赖 Nrf2 的抗氧化通路保护血管平滑肌细胞免受氧化应激，是一种常用的降胆固醇剂。
T5913	Sulbutiamine 舒布硫胺,Bisibuthiamine	Antioxidant	oxidation-reduction
	Sulbutiamine (Bisibuthiamine) 是合成的维生素 B1 类似物，可用于研究无力症。
T12059L	Mitoquinone mesylate MitoQ mesylate,米托蒽醌甲磺酸盐,MitoQ10 mesylate	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Mitoquinone mesylate (MitoQ10 mesylate) 是可防止氧化损伤的抗氧化剂，靶向TPP 的线粒体。
T27064	CP-312 CP312,Cardioprotectant 312	Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	CP-312 (Cardioprotectant 312)是一种抗氧化防御反应激活剂，它通过诱导血红素加氧酶-1发挥作用，通过诱导 HMOX1 表达来靶向抗氧化反应网络，从而保护 hiPSC-CM 的活力。CP-312 保护人 iPSC 衍生的心肌细胞免受氧化应激。
T34268	Raxofelast IRFI016,IRFI-016,IRFI 016
	Raxofelast (IRFI-016) 具有治疗糖尿病并发症和动脉粥样硬化的潜力
T63750	α-Amylase-IN-1	Antioxidant; Amylase	Metabolism; oxidation-reduction
	α-Amylase-IN-1 是一种 α-Amylase 抑制剂（ IC50： 0.5509 μM）。α-Amylase-IN-1 具有抗氧化 (antioxidant) 活性，清除 DPPH 自由基的 IC50 值为 53.49 μM，可用于研究糖尿病和氧化应激相关疾病。
T31615	Elsibucol AGI-1096,UNII-O7T92N1Y8T,AGI 1096	Antioxidant	oxidation-reduction
	Elsibucol (AGI 1096) 是一种VCAM1抑制剂，可用于研究器官移植排斥。Elsibucol 是一种代谢稳定的丙醇衍生物，具有抗氧化、抗炎和抗增殖的特性。它能降低血液中的胆固醇水平，减少受伤动脉中的氧化应激和炎症反应，从而抑制动脉粥样硬化，保护动脉损伤后的内皮愈合。
T26596	Allylpyrocatechol
	Allylpyrocatechol is an antioxidant. Allylpyrocatechol attenuates collagen-induced arthritis via attenuation of oxidative stress secondary to modulation of the MAPK, JAK/STAT, and Nrf2/HO-1 pathways.
T22370	Mitoquinol mesylate	Others	Others
	Mitoquinol, a ubiquinone derivative, specifically accumulates in mitochondria due to the covalent attachment of the cation triphenylphosphonium. Mitoquinol is an antioxidant, protecting mitochondria from oxidative damage and preventing lipid peroxidation-
T40936	Quinclorac
	Quinclorac, a commonly used agricultural herbicide, elicits oxidative stress by triggering the production of free radicals and altering the antioxidant defense system.
T10129	(3S,5R)-Fluvastatin sodium (3S,5R)-XU 62-320	Others	Others
	(3S,5R)-Fluvastatin sodium is the (3S,5R)-enantiomer of Fluvastatin. Fluvastatin is a first fully synthetic, competitive HMG-CoA reductase inhibitor (IC50: 8 nM). Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-
T28047	Mitoquinone-cyclodextrin MitoQ10,Mitoubiquinone mesylate,MitoQ-10,MitoQ,Mito Q10,Mitoquinone mesylate-cyclodextrin
	Mitoquinone-cyclodextrin is a 1:1 molar ratio complex of Mitoquinone mesylate with cyclodextrin. Mitoquinone mesylate is a mitochondria-targeted antioxidant designed to accumulate within mitochondria in vivo in order to protect against oxidative damage. M
T39036	(3R,5S)-Fluvastatin (3R,5S)-Fluvastatin,(3R,5S)-XU 62-320 free acid
	(3R,5S)-Fluvastatin, the 3R,5S-isomer of Fluvastatin (XU 62-320 free acid), stands as the inaugural fully synthetic, competitive inhibitor of HMG-CoA reductase, exhibiting an IC50 value of 8 nM. It safeguards vascular smooth muscle cells from oxidative stress by activating the Nrf2-dependent antioxidant pathway.
T63364	Nrf2 activator-5
	Nrf2 activator-5 是 Nrf2 的有效激活剂，能够减轻 BV-2 小胶质细胞中 H2O2诱导的氧化应激和 LPS 刺激的炎症，表现出抗氧化和抗炎活作用。
T81800	MHLWAAK
	MHLWAAK，抗氧化活性肽，源自C-藻蓝蛋白胰酶水解产物。该肽展现出显著DPPH及ABTS自由基清除效能，并能保护斑马鱼幼虫不受H2O2诱导的氧化损害。
T81828	MDYYFEER
	MDYYFEER 是源自 C-藻蓝蛋白胰酶水解产物的抗氧化活性肽，能有效清除 DPPH 及 ABTS 自由基，并能保护斑马鱼幼虫免受 H2O2 诱导的氧化损害。
T81827	MDYYFEER TFA
	MDYYFEER TFA为从C-藻蓝蛋白胰酶水解产物中提取的抗氧化活性肽，展现了显著的DPPH与ABTS自由基清除效果，并能保护斑马鱼幼虫免遭H2O2诱导的氧化伤害。
T81799	MHLWAAK TFA
	MHLWAAK TFA是从C-藻蓝蛋白胰酶水解产物中分离的抗氧化活性肽。它展现出了较强的DPPH和ABTS自由基清除效应，并且能保护斑马鱼幼虫免遭H2O2引发的氧化伤害。
T36614	DL-Sulforaphane N-acetyl-L-cysteine
	Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents. DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC) is a major ...
T81109	Squalene synthase-IN-1
	Squalene synthase-IN-1（compound 1）是一种通过抑制Squalene Synthase来发挥降血脂作用的有效药物。该化合物也展现了卓越的抗氧化和抗炎特性，能显著降低葡萄糖水平和氧化应激，且不引起毒性。
T81863	MAQAAEYYR TFA
	MAQAAEYYR TFA 是从 C-藻蓝蛋白胰酶水解产物中分离得到的一种具有高抗氧化活性的肽。它展现了显著的 DPPH 及 ABTS 自由基清除作用，并能有效保护斑马鱼幼虫不受 H2O2 诱导的氧化损伤。
T81864	MAQAAEYYR
	MAQAAEYYR 是从C-藻蓝蛋白的胰酶水解产物中分离得到的一种具备显著抗氧化活性的肽。它在DPPH和ABTS自由基清除实验中显示出较高的效率，并能有效保护斑马鱼幼虫免遭H2O2诱导的氧化伤害。
T78071	3-Methylglutaconic acid β-Methylglutaconic acid	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	3-Methylglutaconic acid 是MGTA (3-甲基戊二酸尿症) 的主要积累代谢物，能够诱发脂质和蛋白质的氧化损伤，减弱大脑皮层上清液的非酶促抗氧化防御，导致氧化应激。此化合物适用于研究大脑损伤相关疾病。
T80056	Glutathione Peroxidase GSH-Px,EC 1.11.1.9	Glutathione Peroxidase	Metabolism
	Glutathione Peroxidase (GSH-Px; EC 1.11.1.9)，是一种关键的抗氧化酶，能催化GSH与过氧化氢或脂质过氧化物反应，生成GSSG和H2O，从而减缓氧化应激。此酶在生化研究中具有重要应用。
T80988	Thymolphthalexon tetrasodium
	Thymolphthalexon (tetrasodium) 是一款应用于生化测定的有机试剂，归属于噻吨酮衍生物，展现出显著的抗氧化特性。该化合物在研究自由基反应、氧化应激以及衰老过程中被广泛应用，并作为光动力疗法的光敏剂，助力癌症与其他疾病治疗。
T35860	AP39
	AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP39 (30-300 nM) dose-dependently increases H2S levels in endothelial cells, predominantly in mitochondrial regions. It stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an i...
T63987	Keap1-Nrf2-IN-14
	Keap1-Nrf2-IN-14 是一种 KEAP1-NRF2 抑制剂，可有效破坏 KEAP1-NRF2 相互作用 (IC50: 75 nM)，其对 KEAP1的 Kd=24 nM。Keap1-Nrf2-IN-14 可诱导 NRF2 靶基因表达，能够提高下游的抗氧化和抗炎效果。Keap1-Nrf2-IN-14 能够用于研究氧化应激相关炎症。
T36099	Jacaric Acid
	Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants. Structurally, it is an 18-carbon ω-6 triene isomer of γ-linolenic acid . Jacaric acid induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 μM). It increases the production of reactive oxygen species, and cytotoxicity is abolished by the antioxidant α-tocopherol, suggesting that apoptosis results from oxidative stress. Jacaric acid is metabolized in vivo to conju...
T78698	Aβ-IN-6
	Aβ-IN-6降低小胶质细胞释放的促炎细胞因子，能有效促进Nrf2核转位并抑制Aβ寡聚体的形成。通过调节体内氧化应激的氧化还原敏感信号通路，Aβ-IN-6展现出一致的神经保护效应。具有口服活性的Aβ-IN-6表现出抗炎、抗氧化和抗寡聚特性，并显示出作为阿尔茨海默病(AD)治疗研究潜力。
T35961	Prostaglandin Bx
	PGBx is a mixture of oligomers of PGB1 with a molecular weight of 1,000-1,500. It has antioxidant and free radical trapping activity that was first studied in isolated mitochondria.1 PGBx has anti-inflammatory and cytoprotective activity which may be attributed to inhibition of the 14 kDa sPLA2.2,3 At a dose of 1 mg/kg, PGBx significantly reduces the incidence of ulcers in rats.2References1. Polis, B.D., Polis, E., and Kwong, S. Protection and reactivation of oxidative phosphorylation in mitocho...

化合物

Cat.No: T0412

Synonym: 艾地苯醌,CV-2619

Target: Apoptosis, Antioxidant, Mitochondrial Metabolism

Fluvastatin sodium

Cat.No: T1487

Synonym: XU 62320 sodium,XU-62-320,氟伐他汀钠,Fluvastatin sodium salt

Target: Ferroptosis, HMG-CoA Reductase, Autophagy

Cat.No: T5913

Synonym: 舒布硫胺,Bisibuthiamine

Target: Antioxidant

Mitoquinone mesylate

Cat.No: T12059L

Synonym: MitoQ mesylate,米托蒽醌甲磺酸盐,MitoQ10 mesylate

Target: Reactive Oxygen Species

Cat.No: T27064

Synonym: CP312,Cardioprotectant 312

Target: Reactive Oxygen Species, Autophagy

Cat.No: T34268

Synonym: IRFI016,IRFI-016,IRFI 016

α-Amylase-IN-1

Cat.No: T63750

Target: Antioxidant, Amylase

Cat.No: T31615

Synonym: AGI-1096,UNII-O7T92N1Y8T,AGI 1096

Target: Antioxidant

Allylpyrocatechol

Cat.No: T26596

Mitoquinol mesylate

Cat.No: T22370

Target: Others

Cat.No: T40936

(3S,5R)-Fluvastatin sodium

Cat.No: T10129

Synonym: (3S,5R)-XU 62-320

Target: Others

Mitoquinone-cyclodextrin

Cat.No: T28047

Synonym: MitoQ10,Mitoubiquinone mesylate,MitoQ-10,MitoQ,Mito Q10,Mitoquinone mesylate-cyclodextrin

(3R,5S)-Fluvastatin

Cat.No: T39036

Synonym: (3R,5S)-Fluvastatin,(3R,5S)-XU 62-320 free acid

Nrf2 activator-5

Cat.No: T63364

Cat.No: T81800

Cat.No: T81828

Cat.No: T81827

Cat.No: T81799

DL-Sulforaphane N-acetyl-L-cysteine

Cat.No: T36614

Squalene synthase-IN-1

Cat.No: T81109

Cat.No: T81863

Cat.No: T81864

3-Methylglutaconic acid

Cat.No: T78071

Synonym: β-Methylglutaconic acid

Target: GABA Receptor

Glutathione Peroxidase

Cat.No: T80056

Synonym: GSH-Px,EC 1.11.1.9

Target: Glutathione Peroxidase

Thymolphthalexon tetrasodium

Cat.No: T80988

Cat.No: T35860

Keap1-Nrf2-IN-14

Cat.No: T63987

Cat.No: T36099

Cat.No: T78698

Prostaglandin Bx

Cat.No: T35961

Cat. No.	Product Name	Target	Signaling Pathways
T2S1720	Huperzine B	AChE	Neuroscience
	Huperzine B 是一种从 Huperzia serrata 中分离出的石蒜生物碱，也是一种高度选择性的乙酰胆碱酯酶抑制剂，可以用于改善阿尔茨海默氏病。
T5783	Rosamultin 野蔷薇苷,罗莎白素	Antioxidant; HIV Protease	Microbiology/Virology; oxidation-reduction; Proteases/Proteasome
	Rosamultin 是从Potentilla anserina L 分离的 19 α-羟基型三萜。它抑制 HIV-1 蛋白酶，具有抗氧化、抗炎和镇痛作用。
T41358	2-Hydroxybenzylamine	Others	Others
	2-Hydroxybenzylamine 是一种有效的 IsoLG 小分子清除剂，可将活性物质作为惰性加合物螯合。 2-Hydroxybenzylamine 可用于通过减少具有天然生物分子的 IsoLG 加合物来减少心房颤动消融后心房颤动和其他心房心律失常的早期复发。
T0626	Uric Acid 尿酸,2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate	Reactive Oxygen Species; Endogenous Metabolite; Phosphorylase	Immunology/Inflammation; Metabolism; NF-κB
	Uric Acid (Lithic acid) 是一种重要的抗氧化剂。Uric acid 能清除活性氧(ROS) ，如单线态氧和过氧亚硝酸盐，抑制脂质过氧化。Uric acid 有助于维持血压的稳定和抗氧化应激。
T3S1068	Oxyresveratrol trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,氧化白藜芦醇,Tetrahydroxystilbene	Tyrosinase; Autophagy; HSV	Autophagy; Microbiology/Virology; Proteases/Proteasome
	Oxyresveratrol (trans-Oxyresveratrol) 是非竞争性酪氨酸酶抑制剂，对蘑菇酪氨酸酶的 IC50值为 1.2 µM。它抑制HSV-1，HSV-2和水痘带状疱疹病毒，具有神经保护作用。它是天然抗氧化剂和自由基清除剂。
T37710	5-Hydroxyoxindole	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	5-Hydroxyoxindole 是尿酸的一种结构类似物，具有脂质过氧化抑制活性和自由基 DPPH 清除活性，可用于氧化应激介导的疾病的研究。
TN1461	(-)-Butin Butin,漆黄素 ( 紫铆素)	Akt; PI3K; Nrf2	Cytoskeletal Signaling; Immunology/Inflammation; PI3K/Akt/mTOR signaling
	(-)-Butin (Butin) 是 Butin 的 S 对映体。其中 Butin 是一种分离自黄檀的心材中的生物活性黄酮类化合物，具有显著的抗血小板、抗氧化、抗炎作用。
T8255	(±)-Catechin (±)-Catechin hydrate,儿茶素	ROS; COX	Immunology/Inflammation; Neuroscience
	(±)-Catechin ((±)-Catechin hydrate) hydrate 是 Catechin 的外消旋体，是从云南红豆杉中提取的一种天然产物，具有抗肿瘤、抗肥胖、抗糖尿病、抗心血管、抗感染、保肝和神经保护作用。
T3405	[6]-Gingerol 6-Gingerol,gingerol,(S)-(+)-[6]Gingerol,6-姜酚	Apoptosis; AMPK	Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	[6]-Gingerol ((S)-(+)-[6]Gingerol) 是一种从生姜中分离的活性物质，具有抗癌，抗炎和抗氧化活性。
T6S1966	Curculigoside Curculigoside A,仙茅苷	Antioxidant; NF-κB; JAK; STAT	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; oxidation-reduction; Stem Cells
	Curculigoside (Curculigoside A) 是仙茅中的主要皂苷，具有显著的抗氧化、抗骨质疏松、抗抑郁和神经保护作用。它通过调节JAK/STAT/NF-κB 信号传导途径，具有抗关节炎作用。
T6S1538	Neochlorogenic acid 新绿原酸,trans-5-O-Caffeoylquinic acid,Neochlorogenate,金银花,5-O-Caffeoylquinic acid	TNF; NF-κB; COX; Antibacterial; Interleukin	Apoptosis; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB
	Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) 是在干果和其他植物中发现的一种多酚类天然产物，可抑制iNOS 和COX-2蛋白表达，抑制TNF-α和IL-1β产生，还抑制磷酸化的NF-κB p65和p38 MAPK 活化。
TN1043	Keracyanin chloride Cyanidin-3-O-rutinoside chloride,Cyanidin 3-rutinoside chloride,Cyanidin 3-O-rutinoside chloride,花青素鼠李葡糖苷	COX	Immunology/Inflammation; Neuroscience
	Keracyanin chloride (Cyanidin 3-rutinoside chloride) 是一种花青素，能够抑制氧化的小牛胸腺 DNA 中丙二醛的形成，具有抗氧化作用。
T3787	Didymin Isosakuranetin-7-O-rutinoside,Neoponcirin,香风草甙	Apoptosis; Others	Apoptosis; Others
	Didymin (Neoponcirin) 从柑橘类水果中提取的一种膳食类黄酮苷，具有抗氧化特性。它通过抑制 N-Myc 和上调 RKIP 诱导凋亡。
TN1413	Atranorin 荔枝素，巴美灵,荔枝素	Endogenous Metabolite; NO Synthase; Ras	GPCR/G Protein; Immunology/Inflammation; MAPK; Metabolism
	Atranorin 是地衣的次生代谢产物，具有显着的抗伤害、抗炎和氧化还原活性，对 H(2)O(2) 诱导的氧化应激下的细胞具有细胞保护作用。
T25253	Cinnamtannin B-1 Cinnamtannin B1 (constituent of cinnamomum verum bark),LDN 0022358,LDN-0022358,LDN0022358,肉桂单宁B-1	Antioxidant; COX	Immunology/Inflammation; Neuroscience; oxidation-reduction
	Cinnamtannin B-1 (LDN 0022358) 是一种 A 型原花青素，包含在多种植物中，如越桔、桂树、泽兰肉桂和猪苓。它是一种有效的抗氧化剂和保护剂，可对抗人类血小板的氧化应激和凋亡。它是一种 Cox-2抑制剂。
T2S1008	Oxysophoridine Sophoridine N-oxide,氧化槐定碱	Apoptosis; Antioxidant	Apoptosis; oxidation-reduction
	Oxysophoridine (Sophoridine N-oxide) 是从苦豆子中提取的一种生物碱，具有抗发炎，抗氧化应激和抗凋亡的作用。
TN1725	Hederacolchiside E 革叶常春藤皂苷E	Beta Amyloid; ROS	Immunology/Inflammation; Neuroscience
	Hederacolchiside E 具有抗氧化活性，并通过调节氧化应激在阿尔茨海默病 (AD) 模型中显示神经保护作用。 Hederacolchiside E 对亚油酸乳液的脂质过氧化具有抑制作用。 Hederacolchiside E 可能通过阻断缓激肽或其他炎症介质发挥其抗炎作用。
T11685	Isolongifolene 异长叶烯,(-)-Isolongifolene	Apoptosis; Others	Apoptosis; Others
	Isolongifolene ((-)-Isolongifolene) 是一种从调料九里香中分离的三环倍半萜烯，具有抗氧化，抗炎，抗癌和神经保护的特性。它通过调节 PI3K/AKT/GSK-3β 信号通路来减轻鱼藤酮诱导的氧化应激，线粒体功能障碍和细胞凋亡。
TN1594	DL-Syringaresinol (±)-Syringaresinol	Antioxidant; Antifungal	Microbiology/Virology; oxidation-reduction
	DL-Syringaresinol ( (±)-Syringaresinol) 是一种来自与人参浆果的木质素，具有抗炎、抗氧化、镇痛活性和较弱的抗分枝杆菌活性。DL-Syringaresinol 可通过自噬延缓氧化应激诱导的皮肤老化，通过抑制炎症反应来缓解奥沙利铂诱导的神经性疼痛和脓毒症引起的心功能障碍。
T3426	Bacoside A	MMP; Others; TNF; Dopamine Receptor; NOS; ROS	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience; Others; Proteases/Proteasome
	Bacoside A has a possible anticancer activity that could be inducing cell cycle arrest and apoptosis through Notch pathway in GBM in vitro. It exerts cytoprotective efficacy by attenuation of ROS generated through oxidative stress by an increase in the concentration of antioxidant enzymes and sustain membrane integrity which leads to restoring the damage caused by tBHP. Bacoside A can able to inhibit the progression of Experimental Autoimmune Encephalomyelitis (EAE) may be by the inhibition of i...
TN1831	Macranthoside A Kalopanaxsaponin H	Antioxidant	oxidation-reduction
	Macranthoside A (Kalopanaxsaponin H) 是一种从地黄中提取的三萜糖苷，属于环烯醚萜类化合。Macranthoside A 具有抗炎、抗氧化、抗菌和神经保护活性，抑制促炎细胞因子的产生和抑制炎症信号通路的激活，有助于中和有害的自由基，保护细胞免受氧化损伤，可以促进神经元的存活和生长，并防止氧化应激或神经毒性化合物引起的神经元细胞死亡，具有治疗神经退行性疾病、心血管疾病和肝损伤的潜力。
T4S0800	Demethyleneberberine	P450; NOS; NF-κB; HIF; AMPK	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB; PI3K/Akt/mTOR signaling
	Demethyleneberberine 是从黄连中提取的一种天然产物，是线粒体靶向抗氧化剂。它也可作为AMPK 激活剂，用于非酒精性脂肪性肝病的研究。它通过抑制NF-κB 通路和调节 Th 细胞的平衡来减轻小鼠结肠炎并抑制炎症反应。
T3926	Echinatin 刺甘草查尔酮,Retrochalcone	Free radical scavengers	oxidation-reduction
	Echinatin (Retrochalcone) 是分离自中草药甘草中，具有保肝和抗炎活性。在大鼠中，它可以被快速吸收和消除，并广泛分布，绝对生物利用度约为 6.81％。
T41242	Uric acid sodium	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Uric acid sodium 是氧自由基 (oxygen radical) 的清除剂，是一种有效的、常见的抗氧化剂，有助于维持机体血压稳定和抗氧化应激。Uric acid sodium 能清除活性氧 (ROS)，如单线态氧和过氧亚硝酸盐，对脂质过氧化有抑制作用，与痛风性关节病的发病机理和草酸钙结石的形成有关。
T3414	Morroniside 莫诺苷,奎宁树	Apoptosis; MMP; Pyroptosis	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	Morroniside 通过抑制神经元凋亡和 MMP9/2 的表达从而发挥神经保护作用，可作为 db/db 小鼠肝脏炎症反应和脂质代谢的调节剂。它通过抑制高血糖和氧化应激表现出对糖尿病肾损伤和人脐静脉内皮细胞的保护作用。
T5S1805	5,7-Dihydroxychromone 5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮	Others; Virus Protease; PARP; Caspase; Nrf2	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology; Others; Proteases/Proteasome
	5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) 是一种Cudrania tricuspidata 的提取物，通过激活 Nrf2/ARE 信号对 6-OHDA 诱导的氧化应激和细胞凋亡发挥神经保护作用。它抑制 6-OHDA 诱导的 SH-SY5Y 细胞中活化的caspase-3，caspase-9以及切割的PARP 表达。
TN1016	Kukoamine A	NF-κB; Lipoxygenase; DNA/RNA Synthesis; Parasite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; NF-κB
	Kukoamine A 是一种天然的精胺衍生物，具有抗癌、抗高血压、细胞保护、抗氧化和抗炎活性。它是锥虫硫磷还原酶抑制剂，Ki 值为 1.8 μM。
T3753	Sinapinic Acid Sinapic acid,芥子酸,Synapoic acid	Apoptosis; RAAS; Reactive Oxygen Species; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
	Sinapinic Acid (Synapoic acid) 是从 Hydnophytum formicarumJack. 根中分离到的酚类，是HDAC 抑制剂，对ACE-I 的活性也有抑制作用。它有抗肿瘤活性，诱导肿瘤细胞凋亡，具有抗氧化、抗糖尿病的作用。
T4S0969	Obtusifolin 决明蒽醌,决明蒽醌；美决明子素	Antioxidant; NF-κB	NF-κB; oxidation-reduction
	Obtusifolin 是分离自决明子的种子中，能够抑制NF-kB 通路，调节气道上皮细胞中 MUC5AC 粘蛋白的基因表达和产生。它通过靶向甲状旁腺激素相关蛋白来抑制邻苯二甲酸酯诱导的乳腺癌骨转移。
T4S2326	Cornuside 7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside	ERK; p38 MAPK; NF-κB; JNK	MAPK; NF-κB
	Cornuside (Comuside) 是从山茱萸的果实中分离出的环烯醚萜苷，可用于炎症疾病的研究和促进血液循环。它通过下调 MAPK 和 NF-κB 信号通路抑制肥大细胞介导的过敏反应，用于炎性过敏性疾病中的潜能。
T6S2099	Geraniin	Antioxidant; TNF	Apoptosis; oxidation-reduction
	Geraniin 是一种肿瘤坏死因子α释放抑制剂，其IC50值为 43 μM，具有抗肿瘤、抗炎和抗高血糖活性。
T3490	alpha-(3,4-Dihydroxyphenyl)lactic acid	Antioxidant	oxidation-reduction
	alpha-(3,4-Dihydroxyphenyl)lactic acid 具有抗氧化活性，可通过 PI3K/Akt/Nrf2 信号通路增强 HO-1 表达以抑制 6-OHDA 诱导的氧化损伤。
TN3473	Axillarin
	Axillarin has antioxidant activity, it shows xanthine oxidase inhibitory activity ( IC(50) :36.0 uM). Axillarin can strongly protect primary cultured neurons against glutamate-induced oxidative stress.
TN1542	Cycloheterophyllin	NADPH-oxidase; PKA; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Tyrosine Kinase/Adaptors
	Cycloheterophyllin has an antioxidant effect, it is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be used in the research on and prevention of skin photoaging.
TN5044	Specioside	Others	Others
	Specioside has antioxidant, analgesic, anti-dyspeptic, astringent, liver stimulating and wound healing activities. It ameliorates oxidative stress and promotes longevity in Caenorhabditis elegans.
T5S0313	Liguiritigenin-7-O-D-apiosyl-4'-O-D-glucoside Liquiritin apioside,甘草苷元-7-O-D-芹糖-4'-O-D-葡萄糖苷	Others; TNF	Apoptosis; Others
	Liquiritin apioside has antioxidant property by inducing glutathione (GSH) biosynthesis via the inhibition of cytokines and protected lung epithelial cells against cigarette smoke-mediated oxidative stress, might be as protective agent against epithelial
T75699	Coenzyme Q6
	Coenzyme Q6 (Ubiquinone 30)，一种异戊二烯化的苯醌脂质，主要在呼吸电子传输链中发挥作用，并作为脂质抗氧化剂，具备抗氧化性能，能够防止自由基生成和氧化损伤。
TN3675	Cleomiscosin C	LDL	Metabolism
	Cleomiscosin C has antioxidant activity, it protects against the oxidative modification of apoB-100 induced by either Cu2+ or HOCl ( IC50s of 23.6 and 3.9 microM, respectively), suggests that it could be beneficial in preventing LDL oxidation in atheroscl
T4868	gamma-Linolenic acid gamolenic acid,γ-Linolenic acid,γ-亚麻酸	Endogenous Metabolite	Metabolism
	gamma-Linolenic acid (gamolenic acid) 是一种 omega-6 (n-6)，18 碳 (18C-) 多不饱和脂肪酸 (PUFA)，可以从人乳和植物种子油中提取。
TN3806	Dehydroglyasperin C	ERK; IκB/IKK; p38 MAPK; TNF; NF-κB; Akt; COX; PI3K; NADPH; DNA/RNA Synthesis; Nrf2; JNK; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Metabolism; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling
	Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neuroprotective activities, it has protective effects against chronic diseases
TN6284	Taiwanin C	Antioxidant; Immunology/Inflammation related	Immunology/Inflammation; oxidation-reduction
	Taiwanin C 是一种从台湾植物Cryptocarya chinensis 中提取的化合物，属于木脂素类化合物，具有抗炎、抗氧化和抗癌等多种生物活性。Taiwanin C 对细胞中炎症介质和氧化应激的产生具有抑制作用。
T35624	Ajoene
	Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs = 5-160 &#181g/ml) and Gram-negative bacteria (MICs = 136-200 &#181g/ml), as well as yeasts (MICs = 10-20 &#181g/ml).1Ajoene is cytotoxic to mouse melanoma cells (IC50= 18 &#181M), as well as human colon, lung, mammary, and pancreatic cancer cells (IC50s = 7-41 &#181M).2It reduces...

天然产物

Cat.No: T2S1720

Target: AChE

Cat.No: T5783

Synonym: 野蔷薇苷,罗莎白素

Target: Antioxidant, HIV Protease

2-Hydroxybenzylamine

Cat.No: T41358

Target: Others

Cat.No: T0626

Synonym: 尿酸,2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate

Target: Reactive Oxygen Species, Endogenous Metabolite, Phosphorylase

Cat.No: T3S1068

Synonym: trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,氧化白藜芦醇,Tetrahydroxystilbene

Target: Tyrosinase, Autophagy, HSV

5-Hydroxyoxindole

Cat.No: T37710

Target: Reactive Oxygen Species

Cat.No: TN1461

Synonym: Butin,漆黄素 ( 紫铆素)

Target: Akt, PI3K, Nrf2

Cat.No: T8255

Synonym: (±)-Catechin hydrate,儿茶素

Target: ROS, COX

Cat.No: T3405

Synonym: 6-Gingerol,gingerol,(S)-(+)-[6]Gingerol,6-姜酚

Target: Apoptosis, AMPK

Cat.No: T6S1966

Synonym: Curculigoside A,仙茅苷

Target: Antioxidant, NF-κB, JAK, STAT

Neochlorogenic acid

Cat.No: T6S1538

Synonym: 新绿原酸,trans-5-O-Caffeoylquinic acid,Neochlorogenate,金银花,5-O-Caffeoylquinic acid

Target: TNF, NF-κB, COX, Antibacterial, Interleukin

Keracyanin chloride

Cat.No: TN1043

Synonym: Cyanidin-3-O-rutinoside chloride,Cyanidin 3-rutinoside chloride,Cyanidin 3-O-rutinoside chloride,花青素鼠李葡糖苷

Target: COX

Cat.No: T3787

Synonym: Isosakuranetin-7-O-rutinoside,Neoponcirin,香风草甙

Target: Apoptosis, Others

Cat.No: TN1413

Synonym: 荔枝素，巴美灵,荔枝素

Target: Endogenous Metabolite, NO Synthase, Ras

Cinnamtannin B-1

Cat.No: T25253

Synonym: Cinnamtannin B1 (constituent of cinnamomum verum bark),LDN 0022358,LDN-0022358,LDN0022358,肉桂单宁B-1

Target: Antioxidant, COX

Cat.No: T2S1008

Synonym: Sophoridine N-oxide,氧化槐定碱

Target: Apoptosis, Antioxidant

Hederacolchiside E

Cat.No: TN1725

Synonym: 革叶常春藤皂苷E

Target: Beta Amyloid, ROS

Cat.No: T11685

Synonym: 异长叶烯,(-)-Isolongifolene

Target: Apoptosis, Others

DL-Syringaresinol

Cat.No: TN1594

Synonym: (±)-Syringaresinol

Target: Antioxidant, Antifungal

Cat.No: T3426

Target: MMP, Others, TNF, Dopamine Receptor, NOS, ROS

Macranthoside A

Cat.No: TN1831

Synonym: Kalopanaxsaponin H

Target: Antioxidant

Demethyleneberberine

Cat.No: T4S0800

Target: P450, NOS, NF-κB, HIF, AMPK

Cat.No: T3926

Synonym: 刺甘草查尔酮,Retrochalcone

Target: Free radical scavengers

Uric acid sodium

Cat.No: T41242

Target: Reactive Oxygen Species

Cat.No: T3414

Synonym: 莫诺苷,奎宁树

Target: Apoptosis, MMP, Pyroptosis

5,7-Dihydroxychromone

Cat.No: T5S1805

Synonym: 5,7-Dihydroxy-4H-Chromen-4-One,5,7-二羟基色酮,5,7-二羟基色原酮

Target: Others, Virus Protease, PARP, Caspase, Nrf2

Cat.No: TN1016

Target: NF-κB, Lipoxygenase, DNA/RNA Synthesis, Parasite

Cat.No: T3753

Synonym: Sinapic acid,芥子酸,Synapoic acid

Target: Apoptosis, RAAS, Reactive Oxygen Species, HDAC

Cat.No: T4S0969

Synonym: 决明蒽醌,决明蒽醌；美决明子素

Target: Antioxidant, NF-κB

Cat.No: T4S2326

Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside

Target: ERK, p38 MAPK, NF-κB, JNK

Cat.No: T6S2099

Target: Antioxidant, TNF

alpha-(3,4-Dihydroxyphenyl)lactic acid

Cat.No: T3490

Target: Antioxidant

Cat.No: TN3473

Cycloheterophyllin

Cat.No: TN1542

Target: NADPH-oxidase, PKA, PKC

Cat.No: TN5044

Target: Others

Liguiritigenin-7-O-D-apiosyl-4'-O-D-glucoside

Cat.No: T5S0313

Synonym: Liquiritin apioside,甘草苷元-7-O-D-芹糖-4'-O-D-葡萄糖苷

Target: Others, TNF

Cat.No: T75699

Cat.No: TN3675

Target: LDL

gamma-Linolenic acid

Cat.No: T4868

Synonym: gamolenic acid,γ-Linolenic acid,γ-亚麻酸

Target: Endogenous Metabolite

Dehydroglyasperin C

Cat.No: TN3806

Target: ERK, IκB/IKK, p38 MAPK, TNF, NF-κB, Akt, COX, PI3K, NADPH, DNA/RNA Synthesis, Nrf2, JNK, Autophagy

Cat.No: TN6284

Target: Antioxidant, Immunology/Inflammation related

Cat.No: T35624

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