Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Raxofelast (IRFI-016) 具有治疗糖尿病并发症和动脉粥样硬化的潜力
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 930 | 现货 | ||
5 mg | ¥ 2,260 | 现货 | ||
10 mg | ¥ 3,380 | 现货 | ||
25 mg | ¥ 5,490 | 现货 | ||
50 mg | ¥ 7,720 | 现货 | ||
100 mg | ¥ 9,870 | 现货 | ||
500 mg | ¥ 19,800 | 现货 |
产品描述 | Raxofelast (IRFI-016) is a hydrophilic, non-systemic, vitamin-like antioxidant that reduces ischemia-reperfusion injury in testis. Raxofelast is a good candidate compound for stopping oxidative stress after acute testicular torsion. Raxofelast has the potential to treat diabetic complications and atherosclerosis. |
体外活性 | In glial cells, We evaluated the power of the antioxidants genistein and IRFI 016 (20-80 microM), compared with glutathione ethyl ester and cysteamine-HCl, to antagonize the effects elicited by glutamate. Alterations of cell redox status were reduced, in a dose-dependent way, by antioxidants; IRFI 016 (80 microM) and genistein (10 microM) almost completely restored glutathione basal levels and significantly diminished ROS production, as well as 100 microM glutathione ethyl ester. These antioxidant effects were stronger than those caused by 500 microM cysteamine-HCl. The activation of p50 and p65 NF-kappaB subunits induced by glutamate exposure was significantly reduced by IRFI 016, acting in a dose-dependent manner. [1] |
体内活性 | The effects of IRFI-016 [2(2,3 Dihydro-5-Acetoxy 4,6,7-Trimethyl-Benzofuranyl) acetic acid] a new radical scavenger were studied following six hours of myocardial ischemia, induced by left coronary artery occlusion in male rats. Occlusion of the coronary artery, furthermore, was associated with an immediate rise in the ST segment of the ECG, which was significantly attenuated by IRFI-016. These findings further suggest that IRFI-016 may be a useful agent in the treatment of myocardial occlusion injury.[2] We have investigated the therapeutic efficacy of raxofelast in rats subjected to carrageenan-induced pleurisy. In vivo, treatment with raxofelast (5, 10, 20 mg kg(-1) intraperitoneally 5 min before carrageenan) prevented in a dose-dependent manner carrageenan-induced pleural exudation and polymorphonuclear migration in rats subjected to carrageenan-induced pleurisy. Lung myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels, as well as histological organ injury, were significantly reduced by raxofelast. Raxofelast (5, 10, 20 mg kg(-1)) treatment significantly reduced peroxynitrite formation as measured prevented the appearance of DNA damage, the decrease in mitochondrial respiration and partially restored the cellular level of NAD+ in ex vivo macrophages harvested from the pleural cavity of rats subjected to carrageenan-induced pleurisy. In conclusion, Study demonstrates that raxofelast, a new hydrophilic vitamin E-like antioxidant agent, exerts multiple protective effects in carrageenan-induced acute inflammation.[3] |
别名 | IRFI016, IRFI-016, IRFI 016 |
分子量 | 278.3 |
分子式 | C15H18O5 |
CAS No. | 128232-14-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (179.66 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.5932 mL | 17.9662 mL | 35.9324 mL | 89.8311 mL |
5 mM | 0.7186 mL | 3.5932 mL | 7.1865 mL | 17.9662 mL | |
10 mM | 0.3593 mL | 1.7966 mL | 3.5932 mL | 8.9831 mL | |
20 mM | 0.1797 mL | 0.8983 mL | 1.7966 mL | 4.4916 mL | |
50 mM | 0.0719 mL | 0.3593 mL | 0.7186 mL | 1.7966 mL | |
100 mM | 0.0359 mL | 0.1797 mL | 0.3593 mL | 0.8983 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Raxofelast 128232-14-4 IRFI016 IRFI-016 IRFI 016 Inhibitor inhibitor inhibit